CN105194447A

CN105194447A - Traditional Chinese medicinal oral solution for treating refractory insomnia and preparation method

Info

Publication number: CN105194447A
Application number: CN201510755191.7A
Authority: CN
Inventors: 陈慧珊
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-11-09
Filing date: 2015-11-09
Publication date: 2015-12-30

Abstract

The invention discloses a traditional Chinese medicinal oral solution for treating refractory insomnia. The oral solution is prepared from the following raw materials in parts by weight: 27-33 parts of processed rhizoma pinelliae, 47-53 parts of coix seeds, 27-33 parts of roasted spina date seed, 12-18 parts of selfheal, 27-33 parts of bamboo shavings, 3-9 parts of honey-fried licorice root, 7-13 parts of white ginseng, 27-33 parts of tuber fleeceflower stems, 27-33 parts of calcined dragon bone, 27-33 parts of calcined oyster, 22-28 parts of salviae miltiorrhizae, 27-33 parts of blighted wheat and 2-8 parts of amber. The oral solution has the effects of clearing and eliminating phlegm-heat, nourishing interior essence, dredging meridians, calming and tranquilizing, is a safe and reliable traditional Chinese medicine composition with no toxic or side effect, high effective ingredient usage rate and quick response.

Description

A kind of Chinese medicine oral liquid and preparation method for the treatment of intractable insomnia

Technical field

The present invention relates to a kind of Chinese medicine oral liquid for the treatment of intractable insomnia, belong to the field of Chinese medicines.

Background technology

Obstinate asomnia is a kind of commonly encountered diseases, compared with insomnia secondary, its treatment difficulty is larger, obstinate asomnia is often because psychological factor causes, clinical main manifestations is difficulty falling asleep and maintains dyskoimesis, in the daytime tired out sense, more thinking night falls asleep as early as possible more has difficulty in going to sleep, precipitate psychosocial conflicts, produce nervous, anxiety, emotional lability, undue worries, conscious misery more causes insomnia, form vicious cycle, reason one: caffeine is taken in too many: caffeine can make people have difficulty in going to sleep, especially to the people of its sensitivity, caffeine is not singly just have in coffee, other are as tea, chocolate, soda pop, laughable, even hedex, coldrex, inoitantia, diuretic, appetrol etc. also have this material, even if not too responsive to caffeine, if it is excessive to take, also there will be insomnia, tremble, nervous, dysphoria, cardiopalmus, feel sick, the phenomenon such as dizzy, if take caffeine every day just there will be above-mentioned symptom more than 600 milligrams, reason two: have meal too late: someone think have enough after can be sleepy, easy sleep, in fact, belly is filled out full, digestive system will work with strength, instead make people not able person sleep, therefore, the arrangement of one day breakfast, lunch and dinner should be that breakfast enriches, lunch more arbitrarily, dinner is eaten less, wake up midnight as worried hungry, cannot sleep again, the flesh of fish is had some during dinner, Carnis Gallus domesticus or containing the nutritious food such as vegetable protein, if surfeit is strong or stodge you sleep bad, must guard against the food that jealous road is strong when dinner, as Bulbus Allii etc., because these foods can make your dyspepsia, in addition, also insomnia can be caused to monosodium glutamate sensitivity, finally, avoid bean class, Radix Raphani, cauliflowers etc. produce the food of a large amount of gas in digestion process, reason three: go on a diet improper: suffer from hunger to lose weight, result is waken up midnight, hungry, cannot fall asleep, the western medical treatment Main Means taked this disease at present takes sleeping pill, pressure allows oneself falls asleep, but western medicine is temporary transient symptom management mostly, cause intractable insomnia Relapse rate difficulty more.

Summary of the invention

For the deficiencies in the prior art, the object of this invention is to provide a kind of Chinese medicine oral liquid for the treatment of intractable insomnia, it has clearing and dissipating phlegm-heat, supports effect of middle dredging collateral, mind tranquilizing and the heart calming.

The present invention is achieved through the following technical solutions:

Treat a Chinese medicine oral liquid for intractable insomnia, be made up of following raw material: Rhizoma Pinelliae Preparata 27-33 part, Semen Coicis 47-53 part, Semen Ziziphi Spinosae (parched) 27-33 part, Spica Prunellae 12-18 part, Caulis Bambusae In Taenia 27-33 part, Radix Glycyrrhizae Preparata 3-9 part, Radix Ginseng 7-13 part, Caulis Polygoni Multiflori 27-33 part, Os Draconis (calcined) 27-33 part, Concha Ostreae (calcined) 27-33 part, Radix Salviae Miltiorrhizae 22-28 part, Fructus Tritici Levis 27-33 part, succinum 2-8 part.

Preferably, each parts by weight of raw materials is: Rhizoma Pinelliae Preparata 30 parts, Semen Coicis 50 parts, Semen Ziziphi Spinosae (parched) 30 parts, Spica Prunellae 15 parts, Caulis Bambusae In Taenia 30 parts, Radix Glycyrrhizae Preparata 6 parts, Radix Ginseng 10 parts, Caulis Polygoni Multiflori 30 parts, Os Draconis (calcined) 30 parts, Concha Ostreae (calcined) 30 parts, Radix Salviae Miltiorrhizae 25 parts, Fructus Tritici Levis 30 parts, succinum 5 parts.

Pharmacological action:

Rhizoma Pinelliae Preparata: meridian distribution of property and flavor: pungent, temperature; Poisonous; Return spleen, stomach, lung meridian; Effect: drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass, externally used detumescence pain relieving.

Semen Coicis: nature and flavor with return through: sweet, light, cool; Return spleen, stomach, lung meridian, function with cure mainly: spleen invigorating eliminating dampness by diuresis, eliminating impediment antidiarrheal, heat clearing away row dense; For edema, beriberi, dysuria, arthralgia chiefly caused by damp pathogen contracture, diarrhea due to hypofunction of the spleen, lung abscess, intestinal carbuncle; Verruca plana;

Semen Ziziphi Spinosae (parched): nature and flavor with return through: sweet, sour, flat; Return liver, gallbladder, heart channel, function with cure mainly: tonifying liver, mind calming, arresting sweating, promotes the production of body fluid; For restlessness of asrhenia type and insomnia, palpitation with fear dreaminess, the empty hyperhidrosis of body, Tianjin wound is thirsty.

Spica Prunellae: nature and flavor with return through: pungent, bitter, cold; Return liver, gallbladder meridian, function with cure mainly: relieve inflammation or internal heat, improving eyesight, eliminating stagnation, detumescence; For conjunctival congestion and swelling pain, order pearl nyctalgia, has a headache dizzy, scrofula, goiter, and acute mastitis swells and ache; Thyromegaly, tuberculous lymphadenitis, cyclomastopathy, hypertension.

Caulis Bambusae In Taenia: nature and flavor with return through: sweet, be slightly cold; Attach to the lung and stomach meridians, function with cure mainly: removing heat-phlegm, relieve restlessness and prevent vomiting; For phlegm-heat cough, expectorant held under the arm by gallbladder fire, and dysphoria with smothery sensation is vomitted, and eye is lost in palpitation with fear, middle wind-phlegm fan, aphasia with stiff tongue, gastropyretic vomiting, pregnancy reactions, frequent fetal movement.

Radix Glycyrrhizae Preparata: Xing taste Gui Jing ﹕ is sweet is flat; GUIXIN, lung, spleen, stomach warp; Function Zhu Zhi ﹕ spleen reinforcing stomach function regulating, Yiqi and vein recovery; For weakness of the spleen and stomach, fatigue and weakness, severe palpitation, irregularly intermittent and regularly intermittent pulse, can separate Radix Aconiti Lateralis Preparata poison, zhigancao decoction has benefiting qi and nourishing yin, and activate yang multiple arteries and veins therapeutic efficiency.

Radix Ginseng: nature and flavor: sweet, flat, micro-hardship, slightly cold; There is the function of tonifying QI to produce body fluid, the mind calming and mentality promoting, it can promote the production of body fluid, yin nourishing and clearind deficient heat; Various processing beyond Radix Ginseng Rubra, as Radix Ginseng, white sugar ginseng, suncured white ginseng root etc., are generally referred to as Radix Ginseng.

Caulis Polygoni Multiflori: meridian distribution of property and flavor: sweet micro-hardship is flat; Effect: nourish heart, calms the nerves, and dredging collateral dispels the wind, and cures mainly: control insomnia, impairment caused by overstrain, hyperhidrosis, blood deficiency general pain, carbuncle, scrofula, wind skin ulcer scabies; External: alone outer decocting is washed, treating skin wind skin ulcer prurigo, can receive effect of dispelling wind for relieving itching.

Duan Long Gu ﹕ is sweet, puckery, flat; GUIXIN, liver, kidney channel; There is tranquillizing the mind by relieving convulsion, arresting sweating controlling nocturnal emission with astringent drugs, hemostasis astringing intestine to stop diarrhea, the effect of promoting tissue regeneration and ulcer healing; Demented with controlling infantile convulsion, palpitation with a distress feeling is forgetful, insomnia and dreamful sleep, spontaneous sweating, and seminal emission stranguria with turbid discharge, tell nosebleed and have blood in stool, bleeding not during menses, dysentery proctoptosis, ulcer does not close up for a long time.

Concha Ostreae (calcined): nature and flavor with return through: salty, be slightly cold; Return liver, gallbladder, kidney channel, function with cure mainly: tranquillization with heavy prescription, YANG hyperactivity suppressing nourishing YIN, hard masses softening and resolving; For insomnia of palpitating with fear, vertigo and tinnitus, scrofula sucutaneous nodule ， mass in the abdomen mass in the abdomen; Concha Ostreae (calcined) convergence is astringent or styptic treatment for spontaneous sweating; For spontaneous sweating, seminal emission metrorrhagia and leukorrhagia, stomachache acid regurgitation.

Radix Salviae Miltiorrhizae: nature and flavor with return through: bitter, be slightly cold; GUIXIN, Liver Channel, function with cure mainly: stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness; For menoxenia, amenorrhea dysmenorrhea, note of the ancient Chinese abdominal mass is gathered, breast ventral spine pain, pyretic arthralgia pain, and skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.

Fructus Tritici Levis: meridian distribution of property and flavor is sweet, cool in nature; GUIXIN warp; Effect removes deficiency-heat, hidroschesis; Cure mainly for hectic fever due to YIN-deficiency consumptive fever, spontaneous sweating.

Succinum: meridian distribution of property and flavor: sweet is flat; GUIXIN, liver, urinary bladder channel; Effect: tranquillizing the mind by relieving convulsion, blood circulation promoting and blood stasis dispelling, relieving stranguria by diuresis.

Another technical problem to be solved by this invention is to provide a kind of preparation method preparing above-mentioned Chinese medicine oral liquid.

Another technical problem to be solved by this invention is achieved through the following technical solutions:

Treat a preparation method for the Chinese medicine oral liquid of intractable insomnia, be prepared from by following methods:

(1) get raw material Succinum powder and be broken into 100-150 order, cross 100-150 mesh sieve, put into rustless steel container and decoct with water secondary, amount of water is 6-10 times of above-mentioned raw materials weight, and each 1-2 hour collecting decoction, leaves standstill 24-48 hour 6 DEG C time, filters, for subsequent use;

(2) get raw material Os Draconis (calcined), Concha Ostreae (calcined) is ground into 100-150 order, cross 100-150 mesh sieve, put into rustless steel container and decoct with water secondary, amount of water is 6-10 times of above-mentioned raw materials gross weight, and each 1-2 hour collecting decoction, leaves standstill 24-48 hour 6 DEG C time, filter, for subsequent use;

(3) get raw material Rhizoma Pinelliae Preparata, Semen Coicis, Semen Ziziphi Spinosae (parched), Spica Prunellae, Caulis Bambusae In Taenia, Radix Glycyrrhizae Preparata, Radix Ginseng, Caulis Polygoni Multiflori, Radix Salviae Miltiorrhizae, Fructus Tritici Levis put into rustless steel container and decoct with water secondary, amount of water is 6-10 times of above-mentioned raw materials gross weight, temperature 50-95 DEG C, time 1-4h, filter, obtain filtrate and medicinal residues, dregs pressing is gone out filtrate, and filtrate merges, and abandons medicinal residues, obtain filtrate, for subsequent use;

(4) filter in gained filtrate in gained filtrate in step (1) and step (2) and step (3) in gained filtrate feeding divergence type tube centrifuge, charging aperture pressure is greater than 0.05MPa, roller diameter 45-105mm, revolution 10000-28000r/min, obtain filtrate A, for subsequent use;

(5) filter in step (4) in gained filtrate A feeding purpose ceramic-film filter, the aperture of ceramic membrane is 0.05 μm-1.4 μm, and pressure limit is 0.05-0.7MPa, and the scope of crossflow velocity is 4-6m/s, obtains liquor B, for subsequent use;

(6) gained liquor B in step (5) is sent into concentration tank, in concentration tank, be evaporated to the clear paste of relative density 1.01-1.05 during 50-60 DEG C, obtain clear paste C, for subsequent use;

(7) gained clear paste C in step (6) is carried out sterilization fill, select 450ml vial, vial is first scalded with the hot water of 70-85 DEG C, during bottling, clear paste temperature lower than 85 DEG C, must not seal after fill immediately, and sterilization temperature is 100-103 DEG C, time is 10-30min, after room temperature is down in cooling, warehouse-in is finished product, must treat the Chinese medicine oral liquid of intractable insomnia.

Preferably, a kind of preparation method for the treatment of the Chinese medicine oral liquid of intractable insomnia, is prepared from by following methods:

(1) get raw material Succinum powder and be broken into 100 orders, cross 100 mesh sieves, put into rustless steel container and decoct with water secondary, amount of water is 8 times of above-mentioned raw materials weight, each 1.5 hours collecting decoctions, 6 DEG C time, leave standstill 24 hours, filters, for subsequent use;

(2) get raw material Os Draconis (calcined), Concha Ostreae (calcined) is ground into 100 orders, cross 100 mesh sieves, put into rustless steel container and decoct with water secondary, amount of water is 8 times of above-mentioned raw materials gross weight, each 2 hours collecting decoctions, 6 DEG C time, leave standstill 24 hours, filters, for subsequent use;

(3) get raw material Rhizoma Pinelliae Preparata, Semen Coicis, Semen Ziziphi Spinosae (parched), Spica Prunellae, Caulis Bambusae In Taenia, Radix Glycyrrhizae Preparata, Radix Ginseng, Caulis Polygoni Multiflori, Radix Salviae Miltiorrhizae, Fructus Tritici Levis put into rustless steel container and decoct with water secondary, amount of water is 8 times of above-mentioned raw materials gross weight, temperature 95 DEG C, time 1h, filters, obtain filtrate and medicinal residues, dregs pressing is gone out filtrate, and filtrate merges, and abandons medicinal residues, obtain filtrate, for subsequent use;

(4) filter in gained filtrate in gained filtrate in step (1) and step (2) and step (3) in gained filtrate feeding divergence type tube centrifuge, charging aperture pressure is greater than 0.05MPa, roller diameter 75mm, revolution 20000r/min, obtain filtrate A, for subsequent use;

(5) filter in step (4) in gained filtrate A feeding purpose ceramic-film filter, the aperture of ceramic membrane is 1.4 μm, and pressure limit is 0.7MPa, and the scope of crossflow velocity is 6m/s, obtains liquor B, for subsequent use;

(6) gained liquor B in step (5) is sent into concentration tank, when being evaporated to 50 DEG C in concentration tank, the clear paste of relative density 1.01, obtains clear paste C, for subsequent use;

(7) gained clear paste C in step (6) is carried out sterilization fill, select 450ml vial, vial is first scalded with the hot water of 75 DEG C, during bottling, clear paste temperature lower than 85 DEG C, must not seal after fill immediately, and sterilization temperature is 103 DEG C, time is 10min, after room temperature is down in cooling, warehouse-in is finished product, must treat the Chinese medicine oral liquid of intractable insomnia.

Beneficial effect: the present invention has clearing and dissipating phlegm-heat, supports effect of middle dredging collateral, mind tranquilizing and the heart calming, be a kind of safe and reliable, without any side effects, effective ingredient utilization rate is high, the Chinese medicine composition of instant effect.

The present invention adopts pure Chinese medicine to be raw material, according to pathogenic factor and the Clinical symptoms of intractable insomnia, under instruction of Chinese Medicine theory, carry out prescription be prepared from the basis not being raw-material activity, show through clinical efficacy, this medicine has definite curative effect to intractable insomnia, is the ideal treatment medication of a kind of intractable insomnia patient.

Model case

Case 1: Mrs Yin, 50 years old, medical history: took the short dormancy of diazepam in the past, serve on sleeping pill also difficult sleep nearly half a year, now changes Chinese traditional treatment, take Drug therapy of the present invention 7 days, after treatment, patient's difficulty at conscious night symptom of falling asleep alleviates, and can sleep peacefully 4-6 hour, takes Drug therapy of the present invention 1 month, insomnia also takes a turn for the better greatly, substantially cures.

Case 2: Mrs Yuan, 38 years old, medical history: nearly half the eve of the lunar New Year difficulty fall asleep, then dreaming often and waking easily of sleeping, lie awake all night after waking up, now change Chinese traditional treatment, take Drug therapy of the present invention 7 days, after treatment, patient's difficulty at conscious night symptom of falling asleep alleviates, can be slept peacefully 5-6 hour, take Drug therapy of the present invention 1 month, insomnia also takes a turn for the better greatly, substantially cures.

Case 3: Mr. Zhong, 45 years old, medical history: because of the fatigue that works, night often tosses about in bed, self-induction hypomnesis, brain is unintelligible, metal fatigue, unable to do what one wishes, emotion is passionnate, frequent sleeplessness all night, and gastrointestinal is bad, be off one's feed, abdominal distention, defecates rare, take Drug therapy of the present invention 7 days, after treatment, patient's subjective symptoms alleviates, and can sleep peacefully 4-6 hour, take Drug therapy of the present invention 1 month, insomnia also takes a turn for the better greatly, substantially cures.

Case 4: Mr. Wen, 45 years old, medical history: insomnia is many for half a year, most multipotency is slept 1-2 hour every night, usually lie awake all night, also often occur palpitation and short breath, uncomfortable in chest, feel suffocated, body constitution declines, myasthenia of limbs, headache increases the weight of, and head countersunk head is tight, even sore waist and aching in the waist and the back, the whole body is uncomfortable, conventional sleeping pill stomach medicine, poor effect, take Drug therapy of the present invention 7 days, after treatment, patient's subjective symptoms alleviates, and can sleep peacefully 4-6 hour, take Drug therapy of the present invention 1 month, insomnia also takes a turn for the better greatly, substantially cures.

Case 5: Mr. Xu, 56 years old, medical history: have a sleepless night more than 1 year, often can only sleep 2-3 hour every night, and dreaminess; Immediate cause is on the night shift, and daytime is more difficult sleeps, Mental fatigue, and lusterless complexion, takes Drug therapy of the present invention 7 days, and after treatment, patient's subjective symptoms alleviates, and can sleep peacefully 5-6 hour, takes Drug therapy of the present invention 1 month, and insomnia also takes a turn for the better greatly, substantially cures.

Case 6: Mr. Luo, 59 years old, medical history: more than half a year of having a sleepless night, Mental fatigue, lusterless complexion, uncomfortable in chest, feel suffocated, body constitution declines, myasthenia of limbs, headache increases the weight of, and examines, and takes Drug therapy of the present invention 7 days, after treatment, patient's subjective symptoms alleviates, and can sleep peacefully 5-6 hour, takes Drug therapy of the present invention 1 month, insomnia also takes a turn for the better greatly, substantially cures.

Clinical data

Physical data: intractable insomnia patient 50 example, wherein man 29 example, female 21 example, the age be 38-68 year, 53 years old mean age.

Diagnostic criteria: 1. the lighter's difficulty of falling asleep or sleep but easy to wake, be insomnia after waking up, severe one is lain awake all night; 2. normal with headache, dizzy, cardiopalmus, forgetful, the diseases such as dreaminess; 3. through each system and lab testing no abnormal; Intractable insomnia concrete manifestation: difficulty falling asleep, dreaminess, shallow sleep, vexed, irritability, disease are changeable.

Therapeutic Method: take Chinese medicine oral liquid of the present invention, every day 2 times, each 40ml 7 days is a course for the treatment of.

Curative effect determinate standard: 1. fully recover: clinical symptom disappearance, recovers normal the length of one's sleep or more than 6 hours, sleeps deep, energetic after waking up; 2. effective: clinical symptoms disappears substantially, sleep is clearly better, and increases by more than 3 hours the length of one's sleep, and Depth of sleep increases; 3. effective: symptom alleviates, increase the length of one's sleep less than 3 hours; 4. invalid: after treatment, insomnia is not improved or exacerbation of symptoms.

Therapeutic outcome: by this side treatment intractable insomnia patient 50 example, wherein clinical recovery 39 example, effective 6 examples, effective 4 examples, invalid 1 example. total effective rate is 98%.

Detailed description of the invention

Embodiment 1

The present invention treats the preparation of intractable insomnia Chinese medicine oral liquid, and the weight portion of each raw material is: Rhizoma Pinelliae Preparata 33 parts, Semen Coicis 53 parts, Semen Ziziphi Spinosae (parched) 33 parts, Spica Prunellae 18 parts, Caulis Bambusae In Taenia 33 parts, Radix Glycyrrhizae Preparata 9 parts, Radix Ginseng 13 parts, Caulis Polygoni Multiflori 33 parts, Os Draconis (calcined) 33 parts, Concha Ostreae (calcined) 33 parts, Radix Salviae Miltiorrhizae 28 parts, Fructus Tritici Levis 33 parts, succinum 8 parts;

Be prepared from by following methods:

Usage: oral, every day 2 times, each 40ml.

Embodiment 2

The present invention treats the preparation of intractable insomnia Chinese medicine oral liquid, and the weight portion of each raw material is: Rhizoma Pinelliae Preparata 30 parts, Semen Coicis 50 parts, Semen Ziziphi Spinosae (parched) 30 parts, Spica Prunellae 15 parts, Caulis Bambusae In Taenia 30 parts, Radix Glycyrrhizae Preparata 6 parts, Radix Ginseng 10 parts, Caulis Polygoni Multiflori 30 parts, Os Draconis (calcined) 30 parts, Concha Ostreae (calcined) 30 parts, Radix Salviae Miltiorrhizae 25 parts, Fructus Tritici Levis 30 parts, succinum 5 parts;

Be prepared from by following methods:

Usage: oral, every day 2 times, each 40ml.

Embodiment 3

The present invention treats the preparation of intractable insomnia Chinese medicine oral liquid, and the weight portion of each raw material is: Rhizoma Pinelliae Preparata 27 parts, Semen Coicis 47 parts, Semen Ziziphi Spinosae (parched) 27 parts, Spica Prunellae 12 parts, Caulis Bambusae In Taenia 27 parts, Radix Glycyrrhizae Preparata 3 parts, Radix Ginseng 7 parts, Caulis Polygoni Multiflori 27 parts, Os Draconis (calcined) 27 parts, Concha Ostreae (calcined) 27 parts, Radix Salviae Miltiorrhizae 22 parts, Fructus Tritici Levis 27 parts, succinum 2 parts;

Be prepared from by following methods:

Usage: oral, every day 2 times, each 40ml.

Embodiment 4

The present invention treats the preparation of intractable insomnia Chinese medicine oral liquid, and the weight portion of each raw material is: Rhizoma Pinelliae Preparata 29 parts, Semen Coicis 49 parts, Semen Ziziphi Spinosae (parched) 29 parts, Spica Prunellae 14 parts, Caulis Bambusae In Taenia 29 parts, Radix Glycyrrhizae Preparata 5 parts, Radix Ginseng 9 parts, Caulis Polygoni Multiflori 29 parts, Os Draconis (calcined) 29 parts, Concha Ostreae (calcined) 29 parts, Radix Salviae Miltiorrhizae 24 parts, Fructus Tritici Levis 29 parts, succinum 4 parts;

Be prepared from by following methods:

Usage: oral, every day 2 times, each 40ml.

Claims

1. treat a Chinese medicine oral liquid for intractable insomnia, it is characterized in that: be made up of following raw material: Rhizoma Pinelliae Preparata 27-33 part, Semen Coicis 47-53 part, Semen Ziziphi Spinosae (parched) 27-33 part, Spica Prunellae 12-18 part, Caulis Bambusae In Taenia 27-33 part, Radix Glycyrrhizae Preparata 3-9 part, Radix Ginseng 7-13 part, Caulis Polygoni Multiflori 27-33 part, Os Draconis (calcined) 27-33 part, Concha Ostreae (calcined) 27-33 part, Radix Salviae Miltiorrhizae 22-28 part, Fructus Tritici Levis 27-33 part, succinum 2-8 part.

2. a kind of Chinese medicine oral liquid for the treatment of intractable insomnia according to claim 1, is characterized in that: the weight portion of each raw material is: Rhizoma Pinelliae Preparata 30 parts, Semen Coicis 50 parts, Semen Ziziphi Spinosae (parched) 30 parts, Spica Prunellae 15 parts, Caulis Bambusae In Taenia 30 parts, Radix Glycyrrhizae Preparata 6 parts, Radix Ginseng 10 parts, Caulis Polygoni Multiflori 30 parts, Os Draconis (calcined) 30 parts, Concha Ostreae (calcined) 30 parts, Radix Salviae Miltiorrhizae 25 parts, Fructus Tritici Levis 30 parts, succinum 5 parts.

3. a kind of Chinese medicine oral liquid for the treatment of intractable insomnia according to claim 1, is characterized in that: the weight portion of each raw material is: Rhizoma Pinelliae Preparata 27 parts, Semen Coicis 47 parts, Semen Ziziphi Spinosae (parched) 27 parts, Spica Prunellae 12 parts, Caulis Bambusae In Taenia 27 parts, Radix Glycyrrhizae Preparata 3 parts, Radix Ginseng 7 parts, Caulis Polygoni Multiflori 27 parts, Os Draconis (calcined) 27 parts, Concha Ostreae (calcined) 27 parts, Radix Salviae Miltiorrhizae 22 parts, Fructus Tritici Levis 27 parts, succinum 2 parts.

4. a kind of Chinese medicine oral liquid for the treatment of intractable insomnia according to claim 1, is characterized in that: the weight portion of each raw material is: Rhizoma Pinelliae Preparata 33 parts, Semen Coicis 53 parts, Semen Ziziphi Spinosae (parched) 33 parts, Spica Prunellae 18 parts, Caulis Bambusae In Taenia 33 parts, Radix Glycyrrhizae Preparata 9 parts, Radix Ginseng 13 parts, Caulis Polygoni Multiflori 33 parts, Os Draconis (calcined) 33 parts, Concha Ostreae (calcined) 33 parts, Radix Salviae Miltiorrhizae 28 parts, Fructus Tritici Levis 33 parts, succinum 8 parts.

5. a kind of Chinese medicine oral liquid for the treatment of intractable insomnia according to claim 1, is characterized in that: the weight portion of each raw material is: Rhizoma Pinelliae Preparata 29 parts, Semen Coicis 49 parts, Semen Ziziphi Spinosae (parched) 29 parts, Spica Prunellae 14 parts, Caulis Bambusae In Taenia 29 parts, Radix Glycyrrhizae Preparata 5 parts, Radix Ginseng 9 parts, Caulis Polygoni Multiflori 29 parts, Os Draconis (calcined) 29 parts, Concha Ostreae (calcined) 29 parts, Radix Salviae Miltiorrhizae 24 parts, Fructus Tritici Levis 29 parts, succinum 4 parts.

6. a kind of preparation method for the treatment of the Chinese medicine oral liquid of intractable insomnia according to claim 1 and 2, is characterized in that: be prepared from by following methods:

7. a kind of preparation method for the treatment of the Chinese medicine oral liquid of intractable insomnia according to claim 1 and 2, is characterized in that: be prepared from by following methods: