CN105193455A - Multifrequency adjustable intravascular diasonograph and diagnosis method thereof - Google Patents
Multifrequency adjustable intravascular diasonograph and diagnosis method thereof Download PDFInfo
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Abstract
The invention discloses a multifrequency adjustable intravascular diasonograph and a diagnosis method thereof. The method comprises the following steps: feeding an ultrasonic transducer into an intravascular position to be tested by an ultrasonic catheter; emitting an ultrasonic signal to the intravascular position to be tested, and receiving an echo signal of the intravascular position to be tested and at the same time withdrawing the ultrasonic catheter, wherein at the intravascular positions of different depths, the frequencies of the emitted and/or received ultrasonic signals are different; processing the received ultrasonic signal to obtain an image of the intravascular position to be tested. The diasonograph comprises the ultrasonic catheter, a control unit and an ultrasonic system; the ultrasonic catheter is provided with the ultrasonic transducer for frequency response of limit width, the ultrasonic catheter is used for feeding the ultrasonic transducer into the intravascular position to be tested; the control unit is used for driving and withdrawing the ultrasonic catheter; the ultrasonic system is used for processing the ultrasonic signal to obtain the image of the intravascular position to be tested. Images of tissues at different depths are optimized by the ultrasonic signals of different frequencies, and resolution and penetrating power are improved.
Description
Technical field
The present invention relates to intravascular ultrasound diagnostic apparatus, the intravascular ultrasound diagnostic apparatus that particularly a kind of multifrequency is adjustable and diagnostic method thereof.
Background technology
Intravascular ultrasound (IntravascularUltrasound, IVUS) is a kind of new diagnostic method that the microcatheter technology of Non-Invasive ultrasonic technique and invasive combines.Intravascular ultrasound utilizes microcatheter technology that one miniature ultrasonic transducer is imported Endovascular to detect, and obtains the axial imaging of blood vessel wall, diagnose with assist clinicians to vessel inner lesion.
Be easy to the atherosclerotic lesion broken, i.e. vulnerable plaque, refer to all specklees easily causing thrombosis or fast-developing can become Culprit fart.In recent years because vulnerable plaque in arteria coronaria breaks, to corrode and the sickness rate of acute coronary artery syndrome that secondary thrombus is formed and causes increases day by day, the earlier detection of vulnerable plaque more and more receives the concern getting involved cardiologist.The fibrous cap on arteriosclerosis plaque surface judges one of speckle whether rapid wear main Histopathologic appearance.Thin fibrous cap points out this speckle to be crackly vulnerable plaque.Most research is thought, the speckle that fibrous cap thickness is less than 65 μm is vulnerable plaque.Current intravascular ultrasound system on the market only works at most under 45MHz, has the resolution of about 100um.Therefore, commercially available at present intravascular ultrasound system can not detect vulnerable plaque reliably.
Summary of the invention
The present invention is directed to above-mentioned problems of the prior art, the adjustable intravascular ultrasound diagnostic apparatus of a kind of multifrequency and diagnostic method thereof are proposed, support the selection of multiple mid frequency and bandwidth, the ultrasonic signal of different frequency bands scope is used to be optimized different penetration depth, its resolution of effective raising, the resolution solving existing diasonograph is low, detects the problem that vulnerable plaque reliability is low.
For solving the problems of the technologies described above, the present invention is achieved through the following technical solutions:
The invention provides the intravascular ultrasound diagnostic method that a kind of multifrequency is adjustable, it comprises the following steps:
S11: ultrasonic transducer is sent into Ink vessel transfusing detected part by ultrasound catheter;
S12: launch ultrasonic signal by described ultrasonic transducer to described Ink vessel transfusing detected part, and receive its echo-signal, withdraw described ultrasound catheter simultaneously; Wherein, to the different depth place of described Ink vessel transfusing detected part, the mid frequency of the described ultrasonic signal of the transmitting mid frequency of described ultrasonic signal that is different with bandwidth and/or that receive is different with bandwidth;
S13: the described ultrasonic signal received is processed, obtains the image of described Ink vessel transfusing detected part.
The method of current increase diagnostic apparatus resolution has: (1) improves spatial resolution by increasing imaging frequency, but improves frequency merely, image penetration power can be made to decline, reduce the usability in clinical; (2) use Harmonic imaging, likely provide better resolution, it depends on the nonlinear propagation character of tissue, but harmonic imaging performance is limited near field.The ultrasonic transducer that current intravascular ultrasound diagnostic apparatus adopts frequency response narrower, the different demands of imaging can not be met, utilize ultrasonic diagnosis method of the present invention, at launching phase, pulse frequency and the width of transducer can be excited according to imaging demand unrestricted choice, allow transducer be operated in different mid frequencyes and bandwidth; In the reception stage, the ultrasonic signal receiving different frequency can be selected according to interested image-forming range, select more low frequency signal that the penetration power of system can be allowed to strengthen, and select more high-frequency signal that the resolution of system can be allowed to increase, unrestricted choice can be carried out according to the different demands of diagnosis.
Preferably, the different depth place in described Ink vessel transfusing detected part in described step S12, the mid frequency of the described ultrasonic signal the launched mid frequency difference of described ultrasonic signal that is different and/or that receive is further: described Ink vessel transfusing detected part from described ultrasound catheter more away from region, the frequency of the described ultrasonic signal launched and/or receive is lower.From the region close to ultrasound catheter, the frequency of the described ultrasonic signal launched and/or receive is higher.Use the ultrasound wave of high frequency to carry out imaging, improve imaging resolution, obtain blood vessel wall image more clearly, but high frequency ultrasound wave attenuation is fast, propagation distance is short; Use the ultrasound wave of low frequency to carry out imaging, low frequency ultrasound wave attenuation is slow, can detect farther tissue, improve imaging penetration power, obtain the image of blood vessel wall more deep layer, but resolution relative high frequency is poor.
Preferably, the different depth place in described Ink vessel transfusing detected part in described step S12, the mid frequency of described ultrasonic signal the launched mid frequency of described ultrasonic signal that is different with bandwidth and/or that receive is different with bandwidth is further: to the different depth place of described Ink vessel transfusing detected part, is launched and/or the described ultrasonic signal of reception different frequency by the same ultrasonic transducer that frequency response range is wider.Launched the ultrasonic signal of different frequency scope by the same transducer that frequency response range is wider, reduce complexity and the cost of imaging catheter.
Preferably, the different depth place in described Ink vessel transfusing detected part in described step S12, the mid frequency of described ultrasonic signal the launched mid frequency of described ultrasonic signal that is different with bandwidth and/or that receive is different with bandwidth is further: to the different depth place of described Ink vessel transfusing detected part, launched to Ink vessel transfusing detected part by the ultrasonic transducer of multiple different frequency, the described ultrasonic signal of reception different frequency.
Preferably, processing the described ultrasonic signal received in described step S13 is further: adopt different signal processing methods to process to the described ultrasonic signal at the different depth place of described Ink vessel transfusing detected part.
The intravascular ultrasound diagnostic apparatus that the present invention also provides a kind of multifrequency adjustable, it comprises: ultrasound catheter, control unit and ultrasonic system, wherein:
The far-end of described ultrasound catheter is provided with ultrasonic transducer, and described ultrasound catheter is used for described ultrasonic transducer to send into Ink vessel transfusing detected part;
Described control unit is connected with described ultrasound catheter, for driving and withdrawing described ultrasound catheter, also for launching, receiving described ultrasonic signal;
Described ultrasonic system is connected with described control unit, for receiving the ultrasonic signal that the transmission of described control unit comes, and processing described ultrasonic signal, obtaining the image of described Ink vessel transfusing detected part;
When described ultrasound catheter enters described Ink vessel transfusing detected part, to the different depth place of described Ink vessel transfusing detected part, the mid frequency of the described ultrasonic signal of the transmitting mid frequency of described ultrasonic signal that is different with bandwidth and/or that receive is different with bandwidth.
Preferably, described ultrasonic transducer is the broad-band ultrasonic transducer of a frequency band range between 20MHz ~ 120MHz.
Preferably, the diverse location place of described ultrasound catheter is provided with the different ultrasonic transducer of multiple mid frequency.
Preferably, when described ultrasonic system is used for processing described ultrasonic signal, different signal processing methods is adopted to the described ultrasonic signal at Ink vessel transfusing different depth place.
Preferably, described ultrasonic system is also for controlling the frequency band range of the ultrasonic signal that described control unit is launched.
Compared to prior art, the present invention has the following advantages:
(1) the intravascular ultrasound diagnostic apparatus that multifrequency provided by the invention is adjustable and diagnostic method thereof, the imaging of tissue of ultrasonic signal to different penetration depth of different frequency bands scope is used to be optimized, different frequency band ranges can be selected as required, obtain the image of resolution and penetration power optimum combination;
(2) because high frequency sound wave imaging resolution is high, the vulnerable plaque finding to be less than 65 μm is easy to.
Certainly, implement arbitrary product of the present invention might not need to reach above-described all advantages simultaneously.
Accompanying drawing explanation
Below in conjunction with accompanying drawing, embodiments of the present invention are described further:
Fig. 1 is the flow chart of the adjustable intravascular ultrasound diagnostic method of multifrequency of the present invention;
Fig. 2 is the structural representation of the adjustable intravascular ultrasound diagnostic apparatus of multifrequency of the present invention.
Label declaration: 1-ultrasound catheter, 2-control unit, 3-ultrasonic system.
Detailed description of the invention
Elaborate to embodiments of the invention below, the present embodiment is implemented under premised on technical solution of the present invention, give detailed embodiment and concrete operating process, but protection scope of the present invention is not limited to following embodiment.
Composition graphs 1, the intravascular ultrasound diagnostic method adjustable to multifrequency of the present invention is described in detail, and it comprises the following steps:
S11: ultrasonic transducer is sent into Ink vessel transfusing detected part by ultrasound catheter;
S12: launch ultrasonic signal by ultrasonic transducer to Ink vessel transfusing detected part, and receive its echo-signal, withdraw ultrasound catheter simultaneously; Wherein, to the different depth place of Ink vessel transfusing detected part, the mid frequency of the ultrasonic signal of transmitting and bandwidth can carry out the mid frequency of the ultrasonic signal of different selections and/or reception and bandwidth can carry out different selections;
S13: the ultrasonic signal received is processed, obtains the image of Ink vessel transfusing detected part.
Utilize ultrasonic diagnosis method of the present invention, at launching phase, user can according to the pulse frequency of imaging demand unrestricted choice excitation ultrasound transducer and bandwidth, to the different depth place of Ink vessel transfusing detected part, transducer is allowed to be operated in different mid frequencyes, as 40MHz, 60MHz, 80MHz.In the reception stage, user also can select frequency and the bandwidth of Received signal strength according to interested image-forming range, select more low frequency signal that the penetration power of system can be allowed to strengthen, obtain the image of blood vessel wall more deep layer, and select more high-frequency signal that the resolution of system can be allowed to improve, obtain blood vessel wall image more clearly.In addition, system also can Lookup protocol, uses the ultrasonic signal of high frequency to carry out imaging, improve imaging resolution to from the region close to ultrasound catheter; And the lower ultrasonic signal of region frequency of utilization far away carries out imaging, improve penetration power, the image of the Ink vessel transfusing detected part obtained can be the image that multiple frequency is spliced.
Said method can be realized by the mode of the transducer arranging multiple different frequency bands scope on a ultrasound catheter, also can by arranging the ultrasonic transducer of a ultra wide bandwidth on ultrasound catheter.Ultra wide bandwidth ultrasonic transducer manufacturing technology difficulty is higher, but the complexity of ultrasound catheter and cost lower; And using multiple different frequency bands scope transducer, transducer more easily realizes, but the complexity of ultrasound catheter and cost can rise, and two kinds of methods all can realize, and cuts both ways.In preferred embodiment, the ultrasonic signal for the different center frequency at different depth place can adopt different signal processing methods, promotes processing speed and image quality; In addition, the image of a certain frequency band signals can be shown simultaneously, image formed by ultrasonic signals different for multiple mid frequency can be spliced, obtain more excellent image.
Composition graphs 2, the intravascular ultrasound diagnostic apparatus adjustable to multifrequency of the present invention is described in detail, it comprises: ultrasound catheter, control unit and ultrasonic system, and wherein: the far-end of ultrasound catheter is provided with ultrasonic transducer, ultrasound catheter is used for ultrasonic transducer to send into Ink vessel transfusing detected part; Control unit is connected with described ultrasound catheter, for driving and withdrawing ultrasound catheter, also for launching, receiving ultrasonic signal; Ultrasonic system is connected with control unit, for the ultrasonic signal that reception control unit transmission comes, and processes ultrasonic signal, obtains the image of Ink vessel transfusing detected part; When detected part in ultrasound catheter intravasation, to the different depth place of Ink vessel transfusing detected part, mid frequency and the bandwidth of the ultrasonic signal of transmitting and/or reception can carry out different selections, i.e. multi-frequency imaging.
In the present embodiment, ultrasound catheter is provided with the very wide ultrasonic transducer of a frequency band range, its frequency band range is between 20MHz ~ 120MHz, it can use the material such as ceramic piezoelectric material, mono-crystalline piezoelectric materials, Ceramic Composite piezoelectric, monocrystalline composite piezoelectric material, pMUT, cMUT to make, it can according to different demands, in different regions, the ultrasonic signal of launching and receiving different center frequency and bandwidth.
In different embodiment, also on a ultrasound catheter, the narrower ultrasonic transducer of multiple frequency response bandwidth can being installed, for launching the ultrasonic signal of different frequency bands scope, realizing multi-frequency imaging.
When launching, user can pass through pulse center frequencies and the bandwidth of control unit unrestricted choice excitation ultrasound transducer according to imaging demand, also send instruction to control unit by ultrasonic system, allow the pulse that the impulse ejection circuit transmission pulse length of control unit is adjustable; In the reception stage, can be arranged by control unit, select mid frequency and the bandwidth of Received signal strength according to interested image-forming range; Also automatically can be controlled by ultrasonic system, ultrasonic system can specifically organize according to difference the ultrasonic signal received, and judges its sound wave using which kind of frequency, can accomplish the optimum combination of resolution and penetration power.Because the frequency band of ultrasonic transducer is very wide, according to the difference of pumping signal, the ultrasonic signal needed can be produced, coded excitation technology can be adopted simultaneously, strengthen the emitted energy of high-frequency signal, improve the resolution of imaging, to find the vulnerable plaque being less than 65 μm, improve the accuracy of diagnosis.
Disclosed herein is only the preferred embodiments of the present invention, and this description is chosen and specifically described these embodiments, and being to explain principle of the present invention and practical application better, is not limitation of the invention.The modifications and variations that any those skilled in the art do within the scope of description, all should drop in scope that the present invention protects.
Claims (10)
1. the intravascular ultrasound diagnostic method that multifrequency is adjustable, is characterized in that, comprise the following steps:
S11: ultrasonic transducer is sent into Ink vessel transfusing detected part by ultrasound catheter;
S12: launch ultrasonic signal by described ultrasonic transducer to described Ink vessel transfusing detected part, and receive its echo-signal, withdraw described ultrasound catheter simultaneously; Wherein, at the different depth place of described Ink vessel transfusing detected part, the mid frequency of the described ultrasonic signal of the transmitting mid frequency of described ultrasonic signal that is different with bandwidth and/or that receive is different with bandwidth;
S13: the described ultrasonic signal received is processed, obtains the image of described Ink vessel transfusing detected part.
2. the intravascular ultrasound diagnostic method that multifrequency according to claim 1 is adjustable, it is characterized in that, the different depth place in described Ink vessel transfusing detected part in described step S12, the mid frequency of described ultrasonic signal the launched mid frequency of described ultrasonic signal that is different with bandwidth and/or that receive is different with bandwidth is further: described Ink vessel transfusing detected part from described ultrasound catheter more away from region, launch and/or the frequency of described ultrasonic signal of reception lower; Otherwise, from described ultrasound catheter more close to region, launch and/or the frequency of described ultrasonic signal that receives higher.
3. intravascular ultrasound diagnostic method according to claim 1 and 2, it is characterized in that, the different depth place in described Ink vessel transfusing detected part in described step S12, the mid frequency of the described ultrasonic signal of the mid frequency of described ultrasonic signal launched and/or reception different with bandwidth is different with bandwidth is further: at the different depth place of described Ink vessel transfusing detected part, launched and/or receive the described ultrasonic signal of different frequency by same ultrasonic transducer.
4. intravascular ultrasound diagnostic method according to claim 1 and 2, it is characterized in that, the different depth place in described Ink vessel transfusing detected part in described step S12, the mid frequency of described ultrasonic signal the launched mid frequency of described ultrasonic signal that is different with bandwidth and/or that receive is different with bandwidth is further: at the different depth place of described Ink vessel transfusing detected part, is launched and/or the described ultrasonic signal of reception different frequency by the ultrasonic transducer of multiple different center frequency.
5. intravascular ultrasound diagnostic method according to claim 1, it is characterized in that, processing the described ultrasonic signal received in described step S13 is further: adopt different signal processing methods to process to the described ultrasonic signal at the different depth place of described Ink vessel transfusing detected part.
6. the intravascular ultrasound diagnostic apparatus that multifrequency is adjustable, is characterized in that, comprising: ultrasound catheter, control unit and ultrasonic system, wherein:
The far-end of described ultrasound catheter is provided with ultrasonic transducer, and described ultrasound catheter is used for described ultrasonic transducer to send into Ink vessel transfusing detected part;
Described control unit is connected with described ultrasound catheter, for driving and withdrawing described ultrasound catheter, also for launching, receiving described ultrasonic signal;
Described ultrasonic system is connected with described control unit, for receiving the ultrasonic signal that the transmission of described control unit comes, and processing described ultrasonic signal, obtaining the image of described Ink vessel transfusing detected part;
When described ultrasound catheter enters described Ink vessel transfusing detected part, to the different depth place of described Ink vessel transfusing detected part, the mid frequency of the described ultrasonic signal of the transmitting mid frequency of described ultrasonic signal that is different with bandwidth and/or that receive is different with bandwidth.
7. intravascular ultrasound diagnostic apparatus according to claim 6, is characterized in that, described ultrasonic transducer be the broad-band ultrasonic transducer of a frequency band range between 20MHz ~ 120MHz.
8. intravascular ultrasound diagnostic apparatus according to claim 6, is characterized in that, the diverse location place of described ultrasound catheter is provided with the extremely wide ultrasonic transducer of one or more frequency response or the narrower ultrasonic transducer of multiple frequency response.
9. intravascular ultrasound diagnostic apparatus according to claim 6, is characterized in that, when described ultrasonic system is used for processing described ultrasonic signal, can adopt different signal processing methods to the described ultrasonic signal at Ink vessel transfusing different depth place.
10. intravascular ultrasound diagnostic apparatus according to claim 6, is characterized in that, described ultrasonic system is also for controlling the frequency band range of the ultrasonic signal that described control unit is launched.
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Application publication date: 20151230 |