CN105188561A

CN105188561A - Systems, apparatus and methods for tissue dissection

Info

Publication number: CN105188561A
Application number: CN201480017956.0A
Authority: CN
Inventors: 保罗·威博
Original assignee: Individual
Current assignee: Individual
Priority date: 2013-02-14
Filing date: 2014-02-14
Publication date: 2015-12-23
Anticipated expiration: 2034-02-14
Also published as: GB201514773D0; CN105188561B; BR112015019449A2; GB2525800A; WO2014126482A2; AU2014216758A1; EP2956066A4; WO2014126482A3; EP2956066A2

Abstract

Methods, apparatus and systems for tissue dissection and testing are disclosed herein. A method for tissue dissection and testing may comprise inserting a tissue dissecting wand (TD) through an incision in a patient's body. The TD may comprise a tip having a plurality of protrusions with lysing segments positioned between the protrusions to dissect and/or modify tissue. The TD may also comprise a sensor dock positioned on top of the TD that is configured to allow tissue and/or body fluid contact to a sensor. After separating tissue using the lysing segment(s) to access a target region, the sensor may be activated and moved around within the target region to assess tissues.

Description

System, apparatus and method that biological tissue dissects

The simple description of accompanying drawing

This written disclosure will describe indefiniteness and non-comprehensive illustrative embodiment.Below will quote the illustrative embodiment in part picture:

Figure .1a is that a tissue with sensor is dissected an embodiment perspective view of device.This sensor is arranged on tissue and dissects in the groove of device upper surface, and upper cover is opened to demonstrate sensor and base.

Figure .1b schemes the fragmentary, perspective view of .1a embodiment before being.

Figure .1c to scheme in .1a embodiment before being show, upper cover pulls open the perspective view demonstrating sensor and base.

Figure .1d schemes the fragmentary, perspective view of .1c embodiment before being, this figure shows device upper cover of dissecting and is in the state of pulling open.

Figure .1e schemes the perspective view of .1a embodiment before being, this figure shows the biosensor and base closed because upper cover is finally closed.

Figure .1f schemes the Local map of .1e embodiment before being, this figure demonstrates the perspective view that base upper cover is in the state of closing.

Figure .1g is the embodiment sectional view of a upper cover, comprises one and protrudes and a sweep.

Figure .1h is the embodiment sectional view of a base, comprises one and protrudes and a sweep.

Figure .1i schemes the side-looking of .1a embodiment before being, shows a tissue and to dissect the sensor of the device example different from handle axis angle.

Figure .1j schemes the side-looking of .1a embodiment before being, shows a tissue and dissects the sensor of device in the almost parallel example of arbor line.

Figure .1k is that a tissue is dissected the side-looking of alternative embodiment of device, and this figure shows the upper cover with some openings.

Figure .1L is that a tissue is dissected side-looking, the upper cover that this figure shows opening and the operative sensor of emerging from those openings of alternative embodiment of device.

Figure .2a is that tissue is dissected the perspective view of embodiment of device, and this embodiment upper surface has sensor base.The upper cover of base is opened to demonstrate in base and sensor.

Figure .2b schemes the fragmentary, perspective view of .2a embodiment before being.

Figure .2bb is that a tissue is dissected the fragmentary, perspective view of alternative embodiment of device, the handle in this figure by separately to demonstrate a base.

Figure .2c schemes the perspective view of .1a embodiment before being, the upper cover of this embodiment is in the state of pulling open and demonstrates a base and sensor.

Figure .2d schemes the fragmentary, perspective view of .2c embodiment before being, this figure shows device upper cover of dissecting and is in the state of pulling open.

Figure .2e schemes the perspective view of .2a embodiment before being, this figure shows the sensor and base closed because upper cover is finally closed.

Figure .2f schemes the Local map of .2e embodiment before being, this figure demonstrates the perspective view that base upper cover is in the state of closing.

Figure .2g is the embodiment sectional view of a upper cover, comprises a protuberance and a sweep.

Figure .2h is the embodiment sectional view of a base, comprises a protuberance and a concave part.

Figure .2i schemes the side-looking of .2a embodiment before being, presents a tissue and to dissect the device sensor example different from handle axis angle.

Figure .2j be before the side-looking of Fig. 2 a embodiment, present a tissue and to dissect the device sensor example almost parallel with arbor line.

Figure .2k is that a tissue is dissected the side-looking of alternative embodiment of device, and this figure shows the upper cover with some openings.

Figure .2L is that a tissue is dissected side-looking, the upper cover that this figure shows opening and the operative sensor of emerging from those openings of alternative embodiment of device.

Figure .3a is that tissue is dissected the perspective view of embodiment of device, the upper cover that this embodiment upper surface has sensor base and opens.This embodiment does not have most advanced and sophisticated protuberance or cracking section.

Figure .3b schemes the fragmentary, perspective view of .3a embodiment before being.

Figure .3bb schemes the fragmentary, perspective view of .3a embodiment before being.In this embodiment base can position among handle or most advanced and sophisticated and can display after separately at handle or tip.

Figure .3c schemes the perspective view of .3a embodiment before being, the upper cover of this embodiment is in the state of pulling open and demonstrates a base and sensor.

Figure .3d schemes the fragmentary, perspective view of .3c embodiment before being, this figure shows device upper cover of dissecting and is in the state of pulling open.

Figure .3e schemes the perspective view of .3a embodiment before being, this figure shows the sensor and base closed because upper cover is finally closed.

Figure .3f schemes the Local map of .3e embodiment before being, this figure demonstrates the perspective view that base upper cover is in the state of closing.

Figure .3g is the embodiment sectional view of a upper cover, comprises a protuberance and a concave part.

Figure .3h is the embodiment sectional view of a base, comprises one and protrudes and a sweep.

Figure .3i schemes the side-looking of .3a embodiment before being, presents tissue and to dissect the device sensor example different from handle axis angle.

Figure .3j schemes the side-looking of .3a embodiment before being, presents tissue and to dissect the device sensor example almost parallel with arbor line.

Figure .3k is that a tissue is dissected the side-looking of alternative embodiment of device, and this figure shows the upper cover with some openings.

Figure .3L is that a tissue is dissected side-looking, the upper cover that this figure shows opening and the operative sensor of emerging from those openings of alternative embodiment of device.

Figure .4a is one and comprises tissue and to dissect the side-looking of robotic surgical system of device.

Figure .4b present another can with figure .4a in system and robot arm.

Figure .5a is a top view depicting the protuberance of tissue dissector and the embodiment of cracking section.Wherein there are some protuberances and cracking section and central shaft not parallel.

Figure .5b is a top view depicting the protuberance of tissue dissector and the alternative embodiment of cracking section, wherein has some protuberances and cracking section and central shaft not parallel.

Figure .5c is the top view of a tissue dissector alternative embodiment.Wherein there are some protuberances and cracking section and central shaft asymmetric.

Figure .5d is the upward view of a tissue dissector alternative embodiment, wherein has some protuberances and cracking section and central shaft asymmetric, and also has an antenna.

Figure .6 is a row flow chart depicting a kind of using method of the device that Fig. 1 a-j presents.Specifically in order to organize or the sampling of liquid and/or the use of analysis.

Figure .7 is a flow chart depicting by organizing device of dissecting to go a kind of method close to organ.

Figure .8 is a flow chart depicting a kind of method of sample of tissue and/or test.

Figure .9 is a flow chart depicting a kind of method of detection functionality.

Figure .10 embodies the embodiment that comprises modularity replaceable tip and a flexible handle.

Figure .11 describes the embodiment that comprises the handle of a flexible paragraph and a dumb paragraph.

Describe in detail

In some operations, surgeon, patients and staff can need to wait for that the sample obtained by the operation of wound property is transferred to laboratory, in the report that laboratory is returned after accurate quilt and process again, and patient can spend this process under the state of anesthesia.' laboratory on chip ' this technology perhaps can be with and serve facility.Some ' laboratory on chip ' can comprise nano-sensor and optical pickocff.But their placements in vivo or use can bring an environment obstructed with common lab.We perhaps can inside a stalklet or above place a small footprint, give ' chip lab ' outside simulation or create a minienvironment.

The segmentation being meant to tissue of ' dissecting ' this word or from the separation between a tissue plane.(reference: online free medical dictionary).Some people also thinks, and ' dissecting ' includes the meaning single tissue being divided into aliquot.The primary structure of the mankind and other animal bodies is all from embryo fusion plane.Many human organs also follow the embryo fusion plane of originating according to them to be classified.Face between organ is called as ' tissue surface '.Such face can be regarded as substantitally planar (relative face can be biological or object, such as surgical unit) according to the size of opposite face.Give an example, about 5 centimetres of the radius of curvature of a liver of the mankind, but about 1 centimetre wide is used for splitting the surgical unit organized relatively, and the plane curve of liver can be referred to as ' substantially ' plane, is therefore suitable for the instrument that can cut open tissue with the method for ' substantitally planar '.

' minimally invasive surgery ' but this word is used for description one process (operation or other) that have similar effect lower than open operation wound degree.Some minimally invasive surgeries generally use laparoscopic device.Utilize during operation environment that endoscope is seen and Surgery Platform more in addition remote controller go to control instrument.The hole that this kind of operation is generally originally had by skin or health is carried out.The most advanced and sophisticated hospital stay of this kind of operation energy, or permit out-patient treatment (reference: wikipedia).

Multiplely to dissect, dissect, and biological tissue's amendment manner of execution is open at this.These methods can be dissected with biological tissue and amendment rod performs.The various embodiments of this rod can at United States Patent (USP) 6,203, No. 540 " ultrasound wave and laser face-lifting and cracker ", United States Patent (USP) 6,391, No. 023 " thermal energy radiation beauty device ", United States Patent (USP) 6,432, No. 101 " electromagnetic radiation cosmetic surgery device ", United States Patent (USP) 6,440, No. 121 " utilizing high frequency energy to complete the operation device of cosmetic surgery ", United States Patent (USP) 6,974, No. 450 " beauty device ", with United States Patent (USP) 7, find in 494, No. 488 " strengthening of biological tissue of face and tight apparatus and method ".In these patents, " detailed description of the invention " part can be cited and reference at this.Relate to United States Patent (USP) 6,203, No. 540 " ultrasound wave and laser face-lifting and cracker " ' embodiment explanation ' part be again cited and reference.

Therefore various method can be used, and in method, energy and/or time of implementation can be convenient to the temperature of biological tissue to be adjusted to desirable scope by adjustment.Therefore temperature sensor can be incorporated on energy window or surrounding, thus allows surgeon that biological tissue is adjusted to desirable temperature or desirable temperature range.In certain embodiments, sensor can be configured within a period of time, or can provide mean temperature in a segment distance of biological tissue.The system consistent with in this disclosure can be configured to when biological tissue's temperature exceedes critical, or when mean temperature is got to critical, closes or limit and can even transmit.Temperature also perhaps can be prevented to reach critical.

In the embodiment disclosed herein, some can comprise one or more biosensor that can detect and/or analyze biological analyte.This biosensor can comprise, such as, and one or more sensitive biological element, such as biological tissue, microorganism, ferment, antibody, nucleic acid etc.This biosensor can also comprise a magnetic transducer.The system comprising the operation tool of such biosensor can also comprise an electronic system.This electronic system comprises as signal amplifier, processor, can also show the information from biosensor.The biosensor that one or more the embodiment disclosed herein is well used comprises, nano biological sensor, optical biosensor, electrochemically biosensor, voltage endurance biosensor, electronic biosensor, gravimetric analysis biosensor, and be focus biosensor.

In other fact Examples, one or more emission detecting sensor can be provided.In embodiment, these radiation detection machines can be configured to detect all kinds of radiation, comprise beta-particle, gamma ray, x light, alpha-particle, and neutron.Comprise in the embodiment of one or more radiation detector at some, this detector can be arranged in a base of operation tool.This base, mentions in addition herein and illustrates, can be closed by a upper cover.So, a gas, such as a charged gas, can stay in the base when upper cover is closed.A kind of gas like this or multiple gases can utilize fluidic interface in the base to enter in base.Also therefore can utilize the reaction of special nanoparticle, detect the radiation in patient body, these particles can discharge the charged particle of gas electronic in base of sening as an envoy to.

Such as liquid can be utilized to take out excuse by the gas of electronization to be removed base, to be analyzed, as this paper another place spoken of.Such analysis can comprise the ionizing particle that electrode is collected, and also therefore can produce the current signal of speciality.The one or more radiation of this current signal representation exists.

In other embodiments, the electrode used in this analysis can in base, and the signal of generation can electronically carry (wired or wireless) outer just with process to patient body.In addition, signal also can process on device, and by information storage at local memory device.The radiation detection system favourable for one or more embodiment disclosed herein and the example of skill can at MEMS periodicals, " for multiclass radiation detection; mix a Geiger counter of nanoparticle ", 18th, 5th issues, 998-1003 page (in October, 2009), in check.This article is included and all references at this.

Other can be comprised electromagnetic transducer at this by the sensor that one or more embodiment provides, electronic sensor, and temperature sensor.The example of electromagnetic transducer can comprise, colorimeter, electron-optical sensor, infrared sensor, photoelectric detector, fiber optic sensor, and/or LED sensor etc.Further, LED can in a circuit multiplexization, can be used for light in the different time and penetrate to release and can be used for sensing.Electronic sensor example can comprise, oxygen sensor, carbon dioxide sensor, pH glass electrode and/or current sensor etc.Temperature sensor example can comprise infrared thermometer, resistance temperature detector, resistance thermometer, critesistor, thermocouple, thermometer etc.

Include but not limited to the temperature sensor in the useful common use of this disclosed embodiment, resistance temperature detector, such as carbon resistance, thin film thermometer, Wound-rotor type thermometer, or coiled material element.Some embodiment can comprise thermocouple, pyrometer, or non-contact temperature sensor, such as complete radiation or photoelectric sensor.Have in some embodiments, one or more temperature sensor can process with one and/or a display screen is connected, and just looks China better with surgeon or controls the energy transmission in target biological tissue district.Such as, tissue is dissected the temperature of the biological tissue in one or more region around device, to guarantee that the temperature in this region remains in ideal range to have some embodiments can be configured to allow a surgeon imagine.Some embodiments are had to have in addition, or additional configuration.This embodiment can be configured to so that one or more temperature sensor and processor in a feedback circuit and use so that system can the automatically adjusting energy transmission according to temperature data.Such as, when temperature is critical more than one, such as about 65 DEG C and about 90 DEG C time, system can be configured to automatically close or limit more power transfer.In embodiment, critical can between about 68 DEG C and about 75 DEG C.

Have some embodiments to comprise feedback method, such as, utilize vision, audition, or tactile feedback method supplies information to user to guarantee that avoiding excessive power is transferred to biological tissue.In certain embodiments, feedback method can be configured to go when temperature reaches critical to remind surgeon.In certain embodiments, feedback method can be configured to when tissue dissect device go during a specific seat in target area within the regular hour remind surgeon.The example of visual feedback method comprises LED, laser, vision lamp light source, display screen etc.Auditory feedback method comprises speaker, and quarter-bell has acoustic vibration etc.Tactile feedback method example comprises vibrations, mild electrical shock, heat etc.Feedback method can be configured to most critical, critically has different feedbacks each.Such as, critical at first, tissue device of dissecting can be configured to send a kind of sound, and then second overlooking tissue device of dissecting can be configured to send another sound.The second sound can be more loud than first, so that the urgency that prompting is larger, prompting needs to change power transfer and/or mobile current organization and to dissect the seat of device in patient body.In certain embodiments, one or more antenna can occur in the upper of handle or tip.In certain embodiments, a photographic head or optical fibers can be assembled visual information and dissect device seat information to surgeon to provide tissue.

Biological tissue's this word of device of dissecting refers to comprise the method for any biological tissue that is used for dissecting disclosed herein, comprises, and the biological tissue comprising cracking section dissects device and amendment rod, and the biological tissue not comprising cracking section dissects device.

' amendment ' this word can to refer to or comprise by one or more cracking section by energy applications in biological tissue in content, as talked about herein.' amendment ' this word can also refer to use energy window by energy applications in biological tissue in this content, as herein talk about.

More details about various embodiment are by reference and providing together with accompanying drawing now.

Accompanying drawing 1a-j presents biological tissue and to dissect the multiple view of an implement body embodiment.This embodiment presents a upper surface and to dissect device with the biological tissue of sensor base and its removable upper cover.

Figure .a is that a tissue is dissected the perspective view of device embodiment, and this tissue device of dissecting comprises 101, one, tip handle 102, and a handles 103.Being positioned at, handle is a base 184, and this base can hold seat 188, and this is as supporting sensor 189 neatly.In something example, sensor 189 can comprise a nano-sensor.In certain embodiments, base 184 can recessed handle 102 and/or most advanced and sophisticated 101.In certain embodiments, base 184 can be outstanding from handle 102 and/or most advanced and sophisticated 101.In certain embodiments, base 184 can flush in handle 102 and/or most advanced and sophisticated 101.In certain embodiments, sensor 189 can comprise a silicon nanowire sensor.In certain embodiments, sensor 189 can comprise a biological nano sensor.In certain embodiments, nano-sensor 189 can comprise a conductor aggregation and/or glass and/or aggregation and/or plastics and/or Graphene and/or carbon etc.In certain embodiments, can there be fixed seat at seat 188.In certain embodiments, seat 188 is removable.In certain embodiments, sensor 184 can be fixed in seat 188.In certain embodiments, sensor 189 can be separated from seat 188.Expection in an alternate embodiment, can omit seat 188.In certain embodiments, base can comprise lid moving method and/or a covering tip.Caping end 181 and the method 183 for optionally moving a lid can be positioned at proximate base 184.。The example of upper cover moving method can comprise track, groove, track, ratchet, cable, arm, line etc.In the embodiment shown, lid moving method comprises track.A part for described handle can comprise lid moving method 183 in certain embodiments.Expection in an alternate embodiment, can omit lid moving method 183.Base 184 can comprise one or more base wall 185.Base wall 185 can comprise the fluid transfer port 186 for fluid-transporting tubing.Base wall 185 can comprise the fluid extraction port 187 of fluid extraction conduit.Fluid transfer port 186, in certain embodiments, can be configured to carry gas, such as low humidity gas, rare gas and/or other gas become dry for making base 184, particularly after base 184 is cleaned.In such embodiments, fluid extraction port 187 can be used for the gas removing base 184, to allow in the Utopian circulation base 184 of these gases.In certain embodiments, base wall 185 can comprise one or more port one 86 and/or 187.In figure 1 c, lid 180 can move along lid moving method 183, and can be opened or closed by inner control line.In certain embodiments, cover by motor removing.The rear end of lid 182 can be fixed to lid 180.In certain embodiments, the rear end covering 182 is not be fixed to lid and himself be connected to tissue to dissect another part of device.In certain embodiments, base 184 and/or base wall 185 can hold temperature control method 195, and the method is for revising the temperature in base 184 and lid 180.Temperature correction 195 can comprise, such as heater, peltier effect cooler, heat pump etc.Temperature variation 195 can be used for heating the liquid through port one 86.Temperature control method 195 alternately for heat tissue and/or other with described tissue dissect device obtain bodily tissue and/or fluid.In certain embodiments, temperature control method 195 can promote and/or suppress the change of some chemical reaction and/or combination according to demand, to use sensor 189 to detect some biomaterial.In certain embodiments, base 184 and/or base wall 185 can hold hybrid element 196.Temperature control method 195 can comprise a resistance heater in certain embodiments.In contemplated embodiments, heater 195 can comprise thin film resistor and/or piezoelectricity heating means and/or have the miscellaneous equipment heating fluid capacity.In certain embodiments, hybrid element 196 can comprise by the propeller of electrical motor driven.In certain embodiments, hybrid element 196 can comprise the flexible polymer plastics fin of one or more relative inertness.This fin is rotated by motor on a post.Other material for this fin can comprise polymer, metal, pottery etc.In another embodiment, hybrid element 196 can comprise the stirring rod be not attached rotated by vibrations Magnet.In the embodiment of an expection, one group of independent port initial sum can end at base 184, and can be connected by a conduit.This tubes connection is in a piezoelectric pump and/or other fluid motor and/or other fluid drives method.In the embodiment comprising one or more this kind of additional ports, these ports can be arranged on two relative ends of base 184, make to be applied to whole base 184 more equably when one or more fluids are carried and/or when applying vacuum.In an alternate embodiment, temperature control method 195 and/or hybrid element 196 can be omitted in expection.One or more sensor 178 and/or 179 can be positioned on base 184.In certain embodiments, one or more sensor 178 and/or 179 can be positioned at base wall 185 and/or lid 180.Sensor 178 and/or 179 can comprise the object lesson of any discussed sensor relevant to sensor 110 and/or 114.Sensor 178 and/or 179 can report that the base area 184 li of nano-sensor 189 and/or the situation of surrounding and/or situation change.

The method that nano-sensor can be had by its ordinary skill person and manufacture/obtain, the method includes but not limited to: United States Patent (USP) 5,8,022,444B2 title " biosensor and its method manufactured " and/or United States Patent (USP) 8,314,357B2 title " nanowire biosensor of Joule heating " and/or United States Patent (USP) 6,8,236,595B2 title " nanowire sensor; nano-wire array and its manufacture method " and/or " with a silicon nanowire array label dissociative DNA " (kulkarni, the people such as Xu, Ahn, Amin; JBiotechnol, August 31 in 2012; 160 (3-4): 91-6) and/or " conducting polymer: the frontier of biosensor " (the people such as Borole, DD; DesMonomersPolymers, 20069 (1): the 1-11 pages) and/or " conducting polymer of DNA sensor and DNA card: from being fabricated into Molecular Detection " (Mailley, Livache; Nucleic acid and protein electricity ization – in order to realize the electrochemical sensor for chromosome and protein, 2005: the 297-330 pages) and/or " in order to electrochemical DNA detect conducting polymer " (Peng, H.Deng, biological substance, 2009,30 (11): the 2132-2148 pages) and/or " electroactive polymer: Intelligent Material Systems " (Wallace, Spinks, Teasdale, the 317th volume, 1998.(Wanekaya, waits people to biosensor 287-290) based on conductive polymer nanometer line; The handbook of biosensor and biochip, 2007 (2) 831-842 pages) and/or " conduction electroactive polymer: Intelligent Material Systems ", the second edition, 2002 (Wallace, Spinks, Kane-Maguire the 224th page).And/or for DNA detection novel conductive polymer (Peng etc., Macromolecules, 2007,40 (4): the 909-914 pages) and/or " use the sequence variations of nano wire nano-sensor and direct hypersensitization ground electro-detection DNA and DNA " (NanoLetters2,2003,4 (1): 51-54 pages .) and/or " based on silicon nanometer sequence specificity without mark DNA sensor " (Li, etc., NanoLetters2,2004.4 (2): the 245-247 pages .) and/or " use silicon nanowires to detect: charge layer Range-dependent " (the people such as Zhang, nanometer bulletin, 2008.8 (4): the 1066-1070 pages) and/or for High sensitivity and optionally detect biological and chemical material nano wire millimicro sensor (people such as YiCui., Science. the 293rd volume (2001) the 1289th page) and/or United States Patent (USP) 17, 993, No. 538B2, title " is stimulated by energy and removes solid noncondensing gas pattern layers, the solid-state chemical reaction produced with this layer " and/or United States Patent (USP) 7, 674, No. 389B2, title " the exact form amendment of low energy electrons Shu Jinhang nanodevice " and/or U.S. Patent number 5, 645, 740, title " manufactures system and the combination of microtexture substrate and implant " and/or United States Patent (USP) 5, 607, 607, title " manufactures system and the combination of microtexture substrate and implant " and/or United States Patent (USP) 7, 416, 911B2 title " molecular structure is connected with biomolecular structure and the micro structure of quasiconductor and nanostructured by electrochemical method " and/or United States Patent (USP) 7, 294, 526B2 title, " by the nanocomposite optical sensing of molecule from combination " and/or U.S. Patent number 6, 870, 235B2, title " has silicon-on-insulator biosensor apparatus " and/or U.S. Patent application 12/065, No. 857, publication number: US2009/0140167A1, title " the nano tube based sensing system in fabric and manufacture method " and/or United States Patent (USP) 6, 716, No. 620, March 26 calendar year 2001 submits to, be entitled as " biosensor and correlation technique " and/or United States Patent (USP) 7, 129, No. 554B2, be entitled as " nano-sensor " and/or U.S. Patent application 13/209, No. 442, publication number is US2012/0304776A1, be entitled as " chemistry and biomedical nano-sensor ".

In this as reference, its entirety is quoted above.Such as, some are in order to clean and/or be convenient to sensor and use etc. and to exist in base area and/or the transported and/or reagent removed and/or chemical substance and/or biochemicals can include but not limited to, alcoholic solution, mercaptan, SDS (sodium lauryl sulphate), water, argon, sodium chloride, sodium bicarbonate buffer liquid, EGTA (ethylene glycol tetraacetic), EDTA (ethylenediaminetetraacetic acid), sulfo group-NHSdiazirine (sulfo group-SDA), PBS (phosphate buffered saline(PBS)) and/or tween 20 (PBST) etc.Such reagent and/or chemical substance and/or biochemistry and their acquisition and use be those of ordinary skill in the art can technology, include but not limited to: United States Patent (USP) 6,593, No. 093B1, title " detection of A group B streptococcus "; U.S. Patent application publication number 2012/0228155A1 title " analyzes the electromagnetic detection of thing "; U.S. Patent application publication number 2009/0186774A1 title " microarray that septicemia detects "; European patent 2526427A2, is entitled as " quick pathogen diagnosis apparatus and method "; U.S. Patent application publication number 2006/0223080A1, title is " method detecting A group B streptococcus "; " utilize nanoparticle probes to detect scan-side face DNA array " (TATON, MIRKINLESTINGER; Science, JIUYUE in 2000 the 289th volume on the 8th, No. 5485,1757-1760 page .); " utilize nanometer light biosensor detect MRSA " (STROHSAHL, MILLER, KRAUSS; Proc, SPIE, 7167OS roll up, 1-12 page).; " utilize the multiplexing detection of super responsive selectivity of the cancer markers of nano wire nano-sensor " (CIU, king, HUYNHLIEBER; Harvard University, 1-21 page .); " for the field effect transistor sensing device of breast cancer diagnosis " (MOHANTY, CHEN, king, HONG, ROSENBERG, WEAVERERRAMILLI; Boston University, 1-25 page). in this as reference, its entirety is quoted above.

In certain embodiments, sensor 178 and/or sensor 179 can comprise a photographic head.In certain embodiments, sensor 178 and/or sensor 179 can comprise an optical fiber for and/or optical fiber be photographic head and/or CCD photographic head and or other photographic head.

In certain embodiments, one or more electromagnetism delivery element 177 can the tip of position and/or upper cover 180 and/or upper cover 181 most advanced and sophisticated in base 184.Other embodiments can comprise one or more electromagnetism delivery element.Its element organizing any suitable seat on device of dissecting, can include but not limited to sensor 189 or seat 188..Useful electromagnetism delivery element can include but not limited to: LED, laser instrument, fiber optics, filament, photoelectric material, RF transmitter etc.The transmitting of electromagnetism can be absorbed by the emission spectra of the biomolecule on chemicals and/or sensor and/or base area and/or reverberation and/or chemicals and/or biomolecule in certain embodiments, and/or further product can be detected with sensor 178 and/or sensor 179.In certain embodiments, seat 188 can be configured to the one or more parts closing or be at least substantially enclosed in the one or more sensors on seat 188.Such as, in certain embodiments, seat 188 can comprise the periphery that has side plate.Its periphery side plate is configured to seal the sensor be included at least partially wherein..In some this embodiments, side plate can comprise flexible material, such as plastics or elastomeric material, and to make sensor be placed on the inside and seal perimeter, in order to such as, anti-fluid arrives some part of sensor, the lower surface of such as sensor.In other embodiments, seat may be configured with opening, can be extended by this sensor of this opening.In other words, in these embodiments, a part of sensor can be positioned in opening, then a part of sensor, such as, be configured to the part with biological tissue and/or fluid contact, can extend opening from seat.This sensor can be configured to inside seat opening fixing in these embodiments, its fixing means such as, openings snap-fit connection, frictional fit, be threaded, bayonet type fixture etc.Comprising in the embodiment as opening, this opening can be configured to the part of the automatic-sealed sensor adjacent with described opening, such as, by using suitable material, such as self sealss polymer etc.In one embodiment, lid 180 and/or base 184 can be arranged to reflecting electromagnetic radiation.Reflecting electromagnetic radiation and/or there is minute surface character sensor 178 and/or 179 can be allowed for detecting electromagnetic radiation.. in certain embodiments, lid 180 and/or base 184 comprise the film coating of a covering material.In certain embodiments, material can be plastics and/or molded polymeric and/or crystal and/or glass and/or metal etc.In certain embodiments, lid 180 and/or base 184 comprise one deck aluminum.. in certain embodiments, aluminum film comprise a shielded aluminum and/or enhancing aluminum and/or by ultraviolet enhancing aluminum (maker can be EdmundOptics, Barrington, New Jersey, the U.S.).

In the embodiment depicted, cover 180 and can comprise plastics.In other embodiments, cover 180 materials comprised to include but not limited to: polymer, quartz, glass, carbon-based material, silicate and/or metal.

This conduit can also containing electric control wire to help equipment operating.In figure part be not directly exposed to view 1a and 1b and be positioned at protuberance 104 emphasize out groove be conductive tissue cracking element 105.This element makes device operate forward when borrowing electrosurgical generator energy to operate, and dissolves tissue plane.This cracking section can be positioned at the end of conducting element.In certain embodiments, one or more sensor such as sensor 110 and 114 can be arranged on device.Sensor 110 and 114 can comprise any sensor described in this manual.In certain embodiments, sensor 110 and/or sensor 114 can comprise photographic head.In certain embodiments, sensor 110 and/or sensor 114 can comprise optical fiber and/or fiber optic camera machine and/or ccd video camera and/or other photographing unit. other embodiment can tissue dissect what has a high regard for suitable seat on comprise one or more sensor, include but not limited on protuberance, on tip, and on handle.The sensor come in handy comprises heat sensor, photoelectricity or optical pickocff, photographing unit etc.In certain embodiments, one or more sensor can be used monitor close to handle distal end or most advanced and sophisticated on the electric current that can exist pass through after electrical impedance or temperature conditions.Some embodiments can also comprise one or more sensor in conjunction with MEMS (MEMS) technology, such as MEMS gyro instrument, accelerometer etc.Such sensor can be placed in tissue and to dissect many places on device, comprises the seat in handle in certain embodiments.In certain embodiments, sensor 114 can comprise fiber optic component.In one embodiment, sensor can be configured to the temperature of the adjacent tissue of sensing apparatus.Temperature sensor can be configured to the fluid sensing one or more neighboring devices in addition, such as tissue fluid and/or the fluid introduced by surgeon.

Temperature and resistance value can be tracked or be directly connected to microprocessor on a display screen.This microprocessor can signal to controlling electronic installation in case close to or exceed preset value time change and be transported to most advanced and sophisticated energy.Typical instrumentation paths, such as thermal sensing thermistors, widely understood and can by information feed back to analogue amplifier, itself and be transferred to analog-digital converter, form a microprocessor.In certain embodiments, inner or external ultrasound is measured and also can be provided information, and described information can be involved to feedback circuit.In one embodiment, also can be activated with by the tip of energy delivery to handle with low frequency ultrasound transducer in optional, additional heat is provided, can also dissolving be improved.In certain embodiments, the visible light source of a flicker, such as a LED can be arranged on tip.This light source can come the seat of indication device through tissue and/or organ.

In certain embodiments, one or more electromagnetism conveying element 115 can be positioned on tip or handle.Other embodiment can comprise one or more electromagnetism delivery element on tissue dissects any other suitable seat of device, and this element includes but not limited at jut, or on tip, and on described handle.Useful electromagnetism conveying element comprises: LED, laser instrument, optical fiber, long filament, photoelectric material, RF transmitter etc.

As shown in Figure 1a, lever 103 can comprise one or more port.Various conduit can pass through this port.If in certain embodiments conveniently needed for, multiple conduit can be bundled in together.Such as, in the embodiment described, a power transfer conduit harness 198 can be provided.This harness can comprise a cracking section energy conduit 111 and an energy window conduit 112.In addition, miscellaneous conduit harness 199 can be provided.Mixed item pipeline harness 199 can comprise other conduits various, such as, for one or more conduit as sensor 110 and 114, for the conduit of one or more electromagnetism delivery element 115, for fluid transfer port 116 ,/the conduit of vacuum ports 117 of and/or bleeding.

In addition, miscellaneous conduit harness can comprise one or more additional conduits, such as one or more additive fluid delivery conduit.This conduit can carry a liquid or gas to the port one 86 organizing device base 184 li of dissecting.Miscellaneous conduit harness 199 may further include one or more fluid extraction conduit (port one 87 from base 184).This extraction conduit is used for withdrawn fluid (liquid or gas), guides fluid to an independent fluid/chemicals sensor.

This fluid delivery catheter (being directed to port one 86) can be configured to conveying, such as, and buffer agent, cleaning agent, quencher, reagent, biologic artifact, inert compound, gas.The fluid being flowed to port one 86 by delivery conduit can be increased energy, such as, heat, and ultrasonic energy supply can comprise detergent, antibody, medicine etc.

Fluid extraction conduit (from port one 87) not only can be used for extracting the unwanted fluid of health, can also be used for removing the fluid being incorporated into port one 86 by fluid delivery catheter a wash circuit.This fluid is used for originally, and such as, wash and/or sterilize some biological tissues and/or tissue are dissected the parts of device.Fluid extraction conduit (from port one 87) can also carry out withdrawn fluid in order to external analysis.Some embodiment can be configured to provide bubble so that user distinguishes the various fluids that the fluid extraction conduit from port one 87 takes out to many group different fluid.

In certain embodiments, vibrating method 170 can be arranged in handle.Other embodiment can comprise one or more vibrating method in any applicable seat on tissue dissects device, and its seat includes but not limited on jut or tip, and on described handle.Suitable vibrating method can comprise piezoelectric, supersonic motor, stator, piezo-activator, and vibrations motor, such as, be arranged on the eccentric weight on gear.It is ultrasonic that some vibrating method can be configured to launch in 20-40 kilohertz range.Other vibrating methods can comprise the electromagnet actuators of operating frequency range in 150-400 hertz.In certain embodiments, one or more vibrating method may be used for providing additional power, to dissect passing through of device with convenient tissue.In certain embodiments, the impurity that one or more vibrating method can be used for reducing on electrosurgery parts or its hetero-organization is dissected on device parts.In another embodiment, vibrating method directly or indirectly can be connected to one or more described cracking section.

Some vibrating method can help to reduce and/or remove foreign material.In certain embodiments, vibrating method can or be used in operation, help to organize the movement of device between tissue of dissecting in addition.In the described embodiment, expect that low-frequency vibrating method can contribute to described movement especially.In addition, also can to help described movement in the handle of device of dissecting close to tissue vibrating method position.On the contrary, vibrating method is positioned at the accumulation that can be particularly useful in the most advanced and sophisticated upper impurity of prevention close to most advanced and sophisticated and/or the higher vibration frequency method of use.

Fig. 1 d, c illustrate that tissue is dissected device and be moved and reveal the upper cover 180 showing base.

Fig. 1 f, e illustrate at tissue device of dissecting distally mobile to close and/or sealed base with lid 180.

The viewgraph of cross-section of Fig. 1 g upper cover 180 embodiment, comprises the groove 191 described in and a protuberance 192.Groove 192 can be used to guide fluid in upper cover 180, so that fluid-mixing and/or guiding fluid take the seat in base or in upper cover to needs cleaning side and/or guiding fluid to sensor seat and/or the fluid in certain temperature range.As described in similar, protuberance 192 also can be used to guide fluid to one or more described seat and/or in order to a concrete use stirred fluid

Fig. 1 h is the viewgraph of cross-section of base 184 embodiment, comprises the groove 193 described in and a protuberance 194.Groove 193 can be used to guide fluid in base 184, so that fluid-mixing and/or guiding fluid take the seat in base or in upper cover to needs cleaning side and/or guiding fluid to sensor seat and/or the fluid in certain temperature range.As described in similar, protuberance 194 also can be used to guide fluid to one or more described seat and/or in order to a concrete use stirred fluid.In certain embodiments, upper cover 180 and base 184 can create a common space when upper cover 180 belongs to closed condition.In certain embodiments, upper cover protuberance 191 can with base groove 193 or base extension 194 joint effect fluid to a kind of desirable state.In Fig. 1 g and/or 1h, in base 184 and/or upper cover 180 show in inner face, such as to arrange one or more groove 191 and 193, to be conveyed through port one 86 fluid to one or more desirable seat.In certain embodiments, groove can be configured to promote fluid chemical field and/or guide fluid to needing clean region and/or sensor region.In base 184 and/or upper cover 180 show in inner face, such as to arrange one or more groove 192 and 194, to be conveyed through port one 86 fluid to one or more desirable seat.In certain embodiments, groove can be configured to promote fluid chemical field and/or guide fluid to needing clean region and/or sensor region.In certain embodiments, most protuberance can form a groove, in other embodiments one or more groove can upper cover and or base surface formed.Picture figure .14 the upper cover of closedown 180 that show, the space formed in the upper cover 180 that fluid can be closed again promotes to clean.Close upper cover 180 and can also promote isolation biological tissue and/or fluid.Such as, close upper cover 180 can allow to analyze tissue and/or fluid when not infected by other biological tissue and fluid.Cleaning to use the angle of different seat and/or sensor and/or various angle to carry out further.In Fig. 1 i the configuration that shows can mainly in order to catch tissue for analyzing and/or fluid, but some embodiment can be configured to seat 188 and tend to organize the rear end of device of dissecting, and this seat being is towards (tending to) fluid port 186 to promote the cleaning of sensor 189.

In order to the fluid delivery ports 186 of fluid conveying with can also be used to conveying in order to the fluid extraction port 187 of fluid extraction and/or remove fluid, such as, include but not limited to, reagent and/or analyze thing and/or eluent and/or eluate.In certain embodiments, from fluid delivery ports 186 fluid conveying and or from fluid extraction port 187 fluid extraction can with a pump and/or other tubes connection (this tubes connection is connected and the conduit of fluid delivery ports 186 and fluid extraction port 187 in one or two) in a circuit.This circuit is used for recirculation and/or heating and/or insulation and/or mixing and/or add the material that reagent and/or removing reagent and/or other comes from upper cover 180 and/or base 184.In certain embodiments, to dissect outside device at tissue and to connect and the pump of circuit of conduit between port one 87 and port one 86 can be used for mobile fluid.The fluid space that upper cover 180 and base 184 (having spacial element) provide can with to enter and/or Fluid Volume for port one 86 and/or 187 conduit is estimated.The amount that described estimator can calculate with computer-aided design compares.

The side-looking of the embodiment that figure .1i presents before being inside figure .1a, shows location, a seat and/or seat projected state (comprising a nano-sensor) makes this seat can allow have with the tissue of some processes or fluid the example contacted.Described tissue device of dissecting can comprise an executor 190.Executor 190 can comprise a motor in certain embodiments.In certain embodiments, executor 190 can comprise one or more described motor, such as screw drive motor, gear motor, hydraulic motor etc.In certain embodiments, executor 190 can comprise gear-box, motor control circuit, monitor, remote control equipment etc.In certain embodiments, executor 190 can be controlled by steel wire and/or spring or move.In certain embodiments, executor 190 can be manually controlled or move.In certain embodiments, executor 190 can be omitted.In certain embodiments, seat 188 can be configured to manually promote or tilt.In certain embodiments, seat 188 can be configured to and have the arrangement of the different angles of several fixed number between handle 102 and/or base.In other embodiment, seat 188 can be configured to and have the arrangement of numerous different angles between handle 102 and/or base.

For carry the method 197 of ultrasonic energy can be positioned at the base wall 185 li of base 184 li/.Ultrasonic method 197 can be configured to, such as, and hot fluid: contribute to clean one or more parts of device of dissecting of organizing and comprise such as base 184: the mixing helping reagent and/or organic chemicals and/or biomolecule; Biomolecule and/or other material and acceptor and/or sensor is helped to fix; Help to remove biomolecule and/or other materials from acceptor.In the embodiments described, ultrasonic method comprises piezoelectric ceramics.This piezoelectric ceramics can be measured and be approximately 2 millimeters * 2 millimeters * 4 millimeters in certain embodiments.In an alternate embodiment, ultrasonic method 197 can be omitted in expection.In certain embodiments, piezoelectric ceramics is made by lead titanate piezoelectric ceramics that (this material can be referred to as PZT8 or PZT4, be manufactured in Micromechatronics (micro machine), state university, Philadelphia) and can be operated by 2-5 watt between 10-20 volt.And/or can be configured to shake between 300-500 KHz.In certain embodiments, piezoelectrics can comprise quartz and/or Barium metatitanate. and/or membrane polymer Kynoar.In certain embodiments, any dimensional measurement of ultrasonic method is all between 1 millimeter to 20 millimeters.Some embodiment can comprise most ultrasonic method.In certain embodiments, ultrasonic method can be configured in two or more phase cross surface, such as scheme a upper surface of a part of ultrasonic method 197 position and handle 102 in the embodiment shown in .1b, another part position is in the base wall 185 crossing with handle 102 upper surface.In the embodiment shown, wall 185 in the upper surface of handle 102 with the substantially angle of intersection of 90 degree

Figure.In the embodiment that 1i limits, sensor 189 can be made to increase and/or change contact and/or friction in one or more angle at seat 188 and/or sensor 189 position when upper cover is in open mode, the tissue of promotion sensor 189 and process and/or fluid have a desirable reaction.

In the embodiment of figure shown in .1j, can ideally or at least suitable applying for some at least substantially parallel with handle 102 angle seat 188 and/or sensor 189 position.

In certain embodiments, one or more suction/vacuum ports 117 can be provided in tip or far-end handle.Port can be connected to a vacuum; Vacuum can comprise a Beng Huoyige negative pressure chamber or a syringe at fluid conduit systems afterbody.Other embodiments can comprise one or more suction/vacuum ports.Any other place be applicable to of device of dissecting can organized in its seat, comprises and being singly not limited to: on protuberance or on tip and on handle.In certain embodiments, a fluid delivery ports 116 can be provided.In certain embodiments, fluid delivery ports can connect and pump or high-pressure fluid.In certain embodiments, port for good and all can be opened when making primer pump or high-pressure liquid system fluid and can be transferred through its opening.In other embodiments, port can be closed and optionally open to make conveyance fluid.Other embodiments can comprise one or more fluid port.Any other place be applicable to of device of dissecting can organized in its seat, comprises and being singly not limited to: on protuberance or on tip and on handle.Useful fluid port can be dissected device at tissue, and polymer line, flexible pipe etc. comprise passage.The fluid deriving from outlet can comprise ionic liquid, such as salt, medicine (including but not limited to antibiotic, anesthetis, antitumor drug, antibacterial etc.), not ionic liquids, with or gas (including but not limited to nitrogen, argon, air etc.), in certain embodiments, fluid can under high pressure or injected.Although what be worth proposition is that these elements (116 and 117) are not shown in other all figure, any embodiment as herein described can comprise one or more described element.In the embodiment shown, 118 represent an antenna, and such as one is configured to transmission information to the RFID label tag of a receptor or Bluetooth antenna.Comprise in the embodiment of a RFID label tag at antenna 118, described RFID label tag can comprise a RFID transponder.Described RFID label tag can comprise a passive label in other embodiments.Although it should be noted that antenna 118 is not shown in other all figure, any embodiment as herein described can comprise one or more described element.Other embodiments can comprise one or more antenna on any applicable seat of tissue dissector, and its seat includes but not limited on protuberance, or on most advanced and sophisticated and handle.Comprise in the embodiment of a RFID transponder at antenna 118, this transponder can comprise a microwafer, and such as one can rewrite the microwafer of storage.In certain embodiments, described mark size can approximately be less than several millimeter.Card reader can create an ac magnetic field in one embodiment.In the described embodiment, alternating electromagnetic field can in shortwave (13.56 megahertz) or UHF (865-869 megahertz) frequency.What come in handy can see No. 2007/0225550, U.S. Patent application relative to the example of the system and method for the operating theater instruments in patient body for mapping/following the trail of, be entitled as " system and method relative to the 3D of operating theater instruments in patient body follows the trail of ", at this, its full content be incorporated herein by reference.

In certain embodiments, a transmission unit can be provided.This transmission unit can produce an altofrequency electromagnetic field.This electromagnetic field can be configured to be received by a RFID label antenna or other antennas.This antenna can be configured to produce faradic current from elect magnetic field.This electric current can activate the circuit of label, and it can cause from label transmission electromagnetic radiation.In certain embodiments, can reach by modulating the magnetic field that be produced by transmission unit effect of coming round.The radiation of launching from described transmission unit can be different from by the frequency of the electromagnetic radiation of transmitted tag.Like this perhaps, can differentiate and cognitive two signals.In certain embodiments, within the frequency range of the radiation that the frequency of the signal showed can go out at transmission unit.Details about the RFID technique relevant to the one or more embodiments spoken of at this " can determine the system at surgical unit seat " at such as No. 2009/0281419, U.S. Patent application and find.The full content of its patent application publication number is incorporated herein by reference.

In other embodiments, antenna 118 can comprise a Bluetooth antenna.In the described embodiment, the signal intensity of perception from Bluetooth antenna 118 can be configured at the multiple corresponding bluetooth receiver of known location, and these data of triangulation in case by the signal framing from Bluetooth antenna 118 thus the tissue be positioned in patient body is dissected device.Other embodiments can be configured to use based on angle, electronic location Technology and equipment, to be positioned at antenna 118.Some embodiment can comprise use beam antenna, and it can be used for the precision increasing location.Other embodiments can comprise and use other to have hardware for locating and/or signal, such as wireless and cellular signals.

One or more receiver can be configured to the signal receiving label.By assessing the signal intensity of such as multiple receiver, the distance between receiver can be estimated.By the distance estimated, in patient body and/or the dissect seat of device of the tissue at an organ or the concrete seat of local one of other operations can be determined.In certain embodiments, RFID or other localization methods can be connected with a display screen the general seat making surgeon can see at least one label, to dissect device corresponding seat in patient body to understand tissue.

Some embodiment can configure further and the data from antenna can be combined with coming the dissect data of device of self-organizing.Such as, some tissue comprising one or more sensor dissect device embodiment can further together with one or more RFID label tag or antenna configurations.As such, the data from one or more sensor can use together with the data from one or more antenna.Such as, some embodiment can be configured to be supplied to the information from one or more sensor of surgeon from one or more health seat.。Further illustrate with an example, the information of a protein of concerns about bio tissue and/or the content of nucleic acid can be combined with the information at the seat of its detection level.Surgeon is made to obtain relevant information like this; Comprise those places of patient body won sample or detected described content.

At some as stated in embodiment, a display screen can be had to provide the image in a patient body and/or one or more patient body region.Such system can be configured to be supplied to user view prompts, points out which region of inner patient biological tissue of publishing picture fully to be analyzed.Such as, the liver of patient can in respective image area change color when being detected containing certain hepatitis virus.The pixel in described region can be configured in certain embodiments only corresponding area of biological tissue be detected as reach finite concentration boundary in just luminous.

Most advanced and sophisticated 101 can be connected with a robot arm in certain embodiments.In certain embodiments, most advanced and sophisticated 101 can be connected with a robot arm with a part for handle 102.In certain embodiments most advanced and sophisticated 101 and/or a part for handle 102 and/or a part for lever 103 can be connected with a robot arm.In certain embodiments, robot arm can comprise one or more motor, such as screw drive motor, gear motor, hydraulic motor etc.In certain embodiments, robot arm system can comprise gear on worm, video camera, circuit for controlling motor, monitoring, remote control equipment, light source, touch screen etc.

Fig. 1 k and 1L demonstrates tissue and to dissect the alternative embodiment of device, and wherein that upper cover 180 comprises one or more opening (180L of 180k and Fig. 1 L of Fig. 1 k).The embodiment that the element that all the other Fig. 1 K with 1L show can demonstrate with Fig. 1 a-1j is similar or identical.

As shown in figure 1k, at least one opening 180K is present in upper cover 180.In certain embodiments, upper cover 180 can be configured at least fully to cover (except opening 180K) space and make the vacuum applied by port one 87 that 180K can be allowed to have suction.In shown embodiment, opening 180K can be circular.In shown embodiment, opening 180K diameter can be approximately 1.5 millimeters.In other embodiments, the diameter range of opening 180k can be from about 100 microns to about 100 millimeters.In the embodiment of other expection, opening 180k can have various geometry, includes but not limited to square, rectangle and/or polygon.In the described embodiment, sensor 189k can comprise nano-sensor.In certain embodiments, lid 180 can be configured in the inner space at least generally sealed, thus the vacuum that port one 87 is applied can cause opening 180K to have suction.In the embodiments described, seat 188 can lifting and or decline, with allow sensor 189k close to and/or away from opening 180k so as to increase and/or reduce with pass through to be inhaled into after port one 87 applies vacuum in upper cover 180 with the contacting of the tissue in base 184 and/or fluid.Do not show at this view the executor still spoken of in disclosure book other places and can be configured to energy sliding seats 188 and/or sensor 189K.When the fluid after applying suction by port one 87, outside upper cover 180 and/or tissue can be forced/pull to the EDGE CONTACT with opening 180K, these materials can be sucked into opening 180K when organizing device of dissecting have motion or do not move further.Can to contact with sensor 189 and analyzed at dissect fluid beyond device and/or tissue of tissue before.Do not show at this view the element in base and upper cover still spoken of in disclosure book other places can be configured to move, stir and/or change the temperature of the fluid in base and upper cover to contribute to cultivating and/or analyzing and/or analyze again and/or clean and/or safeguard.The fluid entering upper cover 180 can be included but not limited to by several factors drive and restriction: openings of sizes, outside environment, organizational environment, and/or from the normal pressure of the fluid of fluid delivery ports 186 and/or the vacuum from fluid extraction port 187.

The handle of Fig. 1 K comprises antenna 118K further.In the embodiments described, 118K represents an antenna being configured to signal to receiver.In certain embodiments, antenna 118 can comprise any antenna package in this book described by other places containing such as, at this any antenna relevant to antenna 118.Comprise in the embodiment of a RFID label tag at antenna 118, RFID performance can comprise a RFID transponder.

As can be seen in figure il, at least one opening 180L is present in upper cover 180.In the embodiments described, opening 180L can be circular.In the embodiments described, opening 180L approximately has the diameter of 1.5 millimeters.In the embodiment described by Fig. 1 L, the allowing at least partially of sensor 189L can be given prominence to tissue and to be dissected the part of device, enters the space beyond device of dissecting to carry out biological tissue and/or liquid perception and/or to take sample and/or side-looking.In other fact Examples, opening 180L diameter can approximately from 100 microns to 100 millimeters.Various geometry can be had at the embodiment split shed 180L of other expection, include but not limited to square, rectangle and/or polygon.Such as, the opening of rectangle can allow to be pinioned sensor by band and passes through opening.The sensor 189L helped by band can by opening 180L, as can be seen in figure il.The band arrived from the side can similarly be a line.In certain embodiments, the material of sensor and/or described band is flexible.Pliability contributes to the integrity when sensor enters outside environment by opening (above cover and/or organize and dissect on device).In this process tissue dissect device can when having or carry out without when affecting.In the embodiments described, sensor 189L is a nano-sensor.In certain embodiments, upper cover 180 can be configured at least roughly close out after an inner space makes port one 87 apply vacuum and opening 180L can be allowed to have suction.In Fig. 1 L, at least a part for sensor can be given prominence to tissue and to be dissected the opening 180L of device, allows its part contact dissect tissue outside device and/or fluid.In the embodiments described, seat 188 can lifting and or declining, to allow sensor 189L by opening 180L to return tissue outside upper cover and/or base and/or tissue dissect device of the inside of the adjacent upper cover of base and/or contact and/or fluid.Do not show at this view the executor still spoken of in disclosure book other places and can be configured to energy sliding seats 188 and/or sensor 189L.The fluid entering upper cover 180 can be included but not limited to by several factors drive and restriction: openings of sizes, outside environment, organizational environment, and/or from the normal pressure of the fluid of fluid delivery ports 186 and/or the vacuum from fluid extraction port 187.Sensor 189L can receive and/or send one or more signal from/to a datatron backwash.Sensor 189L can by transfer in the outside of upper cover and/or inside upper cover in this process.Can be cleaned when sensor 189L is retracted in upper cover, as herein other local are spoken of.

Sensor 189L can be connected with an antenna, its antenna can receive when sensor 189L transfers outside upper cover 180 and/or send one or more from/to the signal of datatron.Or in addition, can local store by the data of sensor 189L analysis tissue and/or fluid and send later.Such as, the data obtained after analysis can send with signal after 189L is retracted in upper cover 180 again.Alternatively, described signal can send after surgery.Under such method, signal need not use wireless transmission.Some embodiment can be configured to local to store, a bin afterwards, such as USB can from tissue dissect device take out then by its information stored in computer to analyze.

Sensor 189L is retracted can be cleaned after upper cover 180, as herein speak of.In other embodiments, sensor 189L at least partially can position in a flexible roll and/or can be disposable.Such as, some embodiment can comprise one or more flexible nano-sensor 189L.Its sensing station in a flexible roll or the stacking upper part making roll or a stacking part can give prominence to upper cover 180, such as, passes through 180L, to analyze.When tissue, after fluid analysis completes, some embodiment can be configured to can rolling roll, reverses stacking, and/or abandons part that sensor 189L is previously used and/or dew shows new a part of sensor 189L to analyze further.Or the used part of sensor 189L can be stored in tissue and dissect in device and then throw away after operation terminates.In other embodiments, nano-sensor 189L (being such as placed in the nano-sensor on flexible roll) can be given prominence to a part for device of dissecting when not manually being extended/regaining opening 180L flexibly at least partially.The method that flexible nano-sensor can be had by its ordinary skill person and manufacture/obtain, includes but not limited to: the manufacture (Lee, Kim, the Zheng that are used the nano wire electronic product of non-traditional materials by water auxiliary transmission Method of printing; NanoLett, 2011,11 (8): 3435-9) and " forming vertical transitions silicon nanowire array by cracking " (Weisse, Kim, Lee, Zheng; NanoLett2011,11 (3): 1300-1305), at this, its full content is incorporated herein by reference.

The handle of Fig. 1 L comprises an antenna 118L.In the embodiments described, 118L represents the antenna that is configured to send signal to receiver.In certain embodiments, antenna 118L can comprise any antenna spoken of herein, comprises any antenna related with antenna 118L.Comprise in the embodiment of a RFID label tag at antenna 118L, described RFID label tag can comprise a RFID transponder.

At this as shown in Figure 1B (before the fragmentary, perspective view shown in Fig. 1 a), most advanced and sophisticated 101 can by non-conductive and thermal conductivity low material form, the such as plastics of porcelain, epoxy resin, pottery, glass-ceramic or various politef.Or tip can be made up of metal or part or all of insulating conducting material.The part noticing relative projection and opposing recesses can not be seen completely from this visual angle.In certain embodiments, most advanced and sophisticated relatively recessed part is conductive tissue cracking element 105 (usually all can't see at multiple visual angle).This element can have any geometry, comprises a thin columned line; Tissue Lysis element can be plate shape or planar shaped or linear.This element by non-fusible under any operating condition and can not toxic residua metal or alloy form.Ideal material can include but not limited to steel, nickel, alloy, palladium, gold, tungsten, silver, copper and platinum.Thus metal oxidizedly can stop electric current and its function.In an alternate embodiment, the geometry of tip region can comprise not along the protuberance (from depression angle) of the axis of handle; In described alternative embodiment, some can be configured to evil spirit and all spends and/or comprise disposable tip and make a surgeon can change suitable tip according to concrete operation.Or in addition, one or more tip can be disposablely make a surgeon to lose after surgery most advanced and sophisticated then to install a new tip when the continuity of next one operation or current procedure.The upper surface of device can have an energy window 107.In certain embodiments, energy window 107 comprises the window of an electrosurgical energy.In an alternate embodiment, energy window 107 can be omitted in expection.It should be noted that word ' energy window ' is intended to the U.S. Patent number 7,494 as can be spoken of later, 488 li of so-called amendment plane organize windows/districts, and do not need electrosurgical energy in all embodiments.In certain embodiments, its ' energy window ' can comprise other power radiation devices multiple, comprises high frequency, intense pulsed light, laser, heat, microwave and ultrasound.So-called " energy window " does not necessarily represent the region that energy can be supplied to window equably.On the contrary, the application of some energy window can comprise a series of end or other regions.In these ends or region, energy will provide with dispersion zone form, a small amount of or do not have energy to be provided in these regions.This is configured with and helps some application: it can allow the amendment in some particular organization region in dispersion zone.These region inner tissues can without any amendment, or the degree of amendment is few.Due to the restoration methods of some tissue, this configuration may apply some advantage for some.In certain embodiments, second energy window can also be had, and radio frequency electrosurgical energy emitting device or other multiple kinds of energy discharger can be comprised.

Electrocoagulation and/or the TURP energy that breaks can come conduit 111 and/or 112.In certain embodiments, electrocoagulation energy can be transferred to end 107a by the line in handle and handle.Its end is a part for energy window 107.TURP breaks and electrocoagulation electric current can by the electrosurgical generator outside tissue dissector, as BovieAaron1250 ^tMor BovieIconGP ^tMcontrol.In the embodiments described, energy window 107 comprises an electrosurgical energy window.In the embodiments described, energy window 107 comprises one or more electrosurgery element.In described embodiment, energy window 107 comprises one or more outstanding hollow ceramic end 107a, and its 107a is in an insulated ceramic plates; One or more conduction iron nail can pass through hollow end, and can be energized with the power lug by described conduit and be connected.In described embodiment, the iron nail of end 107a comprises operation stainless steel lag screws.In an alternative embodiment, iron nail comprises a conductive covering layer such as, (silver is sliding) coating (from Stryker (transliteration: this figure Rec), surgical (silver-colored skating art), Kalamazoo, Michigan, the U.S.) and or gold and/or titanium nitride (StremChemicalsInc., Robert Newbery baud, Massachusetts, the U.S.). described conductive layer can reduce carbonized residue and piles up and promote that current delivery arrives target biological tissue.In described embodiment, insulated hollow ceramic end 107a is from outstanding about 2 millimeters of energy window 107 plane.Described plane and most advanced and sophisticated 101 and handle 102 planes align.In certain embodiments, energy window 107 can protruding tip 101 and/or handle 102 plane.In one embodiment, energy window 107 size about 10 millimeters of x15 millimeters.In certain embodiments, energy window 107 can most advanced and sophisticated 101 and/handle 102 plane under.In contemplated embodiments, insulated hollow ceramic end 107a can give prominence to 0.5 millimeter within the scope of 20 millimeters from energy window plane.In described lawsuit trial, the one or more hole dias on end 107a are approximately 1.5 millimeters and/or conductive nail diameter is 1.2 millimeters.In described embodiment, electrocoagulation electric current arrives at the iron nail of end 107a from a standard hospital electrosurgical generator.Described Standard surgical generator (can be used for starting electrosurgical energy window), can comprise the generator that BOVIEMEDICAL produces.Such as ModelAaron1250 and IconGP (Clearwater, Florida State, the U.S.) and/or Valleylab/CovidianModelSurgistat2 (state of Colorado Boulder) and/or ErbeElectrosurgical (Tübingen, Germany) etc.This electrosurgical generator can have a maximum power output, 80 watts to 120 watts.In the application that some electrosurgical energy window is arranged, described Electrosurgical generator will run in ' cohesion ' power setting without sound and/or when being moved by surgeon at tissue modification rod, and this setting is the 20%-80% of maximum power output.Tissue modification device is moved by doctor with the speed of one centimetre per second in some applications.In some applications, the electrocoagulation energy pulse arriving at electrosurgical energy window is approximately per second 20 and is recycled to 50 circulations per second.In some applications, the electrocoagulation energy pulse arriving at electrosurgical energy window is approximately per second 1 and is recycled to 200 circulations per second.In certain embodiments, the electric current of electrosurgical energy window can pass through some interpolation gating circuit of this technology common machine outside Electrosurgical generator, makes to obtain obstructed pulse frequency further.In certain embodiments, the electric current of electrosurgical energy window can pass through some interpolation gating circuit of this technology common machine in Electrosurgical generator, makes to obtain obstructed pulse frequency further.

In certain embodiments, electrosurgical energy window 107 can position on handle 102.In an alternate embodiment, this electrosurgical energy window 107 comprises the conductive plate that has end.All covered by an insulating barrier outside the place that this conductive plate has gone out one or more end.In certain embodiments, end be extruded described in enter conductive plate.In certain embodiments, this conductive plate comprises an iron plate and/or a ceramic metal.In one embodiment, iron plate comprises operation rustless steel.In certain embodiments, this conductive plate and/or end directly can scribble a conductive layer such as, (silver is sliding) coating (from Stryker (transliteration: this figure Rec), surgical (silver-colored skating art), Kalamazoo, the state of Michigan, the U.S.) and/or golden and/or titanium nitride (StremChemicalsInc., Robert Newbery baud, the state of Massachusetts, the U.S.).This conductive plate can scribble an insulating barrier in certain embodiments.In certain embodiments, conductive layer first cover conductive plate and then on have insulating barrier.In certain embodiments, this electrical insulator comprises a nonconducting anti-adhesive polymer, such as politef.In certain embodiments, an insulating barrier can cover a conductive plate, and area coverage is from 90% to 98%.Area coverage can from 5% to 90% in other embodiments.In another embodiment, conductive plate can substantitally planar and comprise the outlet that one or more defect causes allowing one or more electronics on the insulating layer.In certain embodiments, the geometry of one or more defect is circular and/or square and/or triangle and/or geometric figure.In certain embodiments, the diameter of insulating barrier geometric form defect is approximately from 1 millimeter to 20 millimeters.In certain embodiments, defect can form a pattern.

In one embodiment, tip size is approximately wide is 1 centimetre, and thickness is 1 to 2 millimeters.The tip of 5 to five/1sts times of these sizes also can be useful.In some veterinary embodiment, the tip of to 20/10ths times of the size before mentioned also can be useful.In certain embodiments, this tip can be independent parts, and this tip is fixed on handle by multiple method, such as fastening mechanism, fit, plastics sonic welded etc.Or in other embodiments, tip can be the part for handle or the continuity of handle made with similar iron material.In certain embodiments, most advanced and sophisticated also can by being insulation and the material of conductor low in calories forms; Such as, porcelain, pottery, glass ceramics, plastics, various politef, carbon, graphite and graphite-fiberglass complex.In certain embodiments, tip can be made up of the carrier matrix of megohmite insulant (such as, pottery or glass material, such as aluminium oxide, zirconium oxide).Cracking section energy conduit 111 is connected with conductive element, so that the electric cracking element 105. of the recess leading from the RF electrosurgical energy of Electrosurgical generator to handle 102 to protuberance 104 in certain embodiments, protuberance can comprise bud shape protuberance.There are four opposing projections recess relative to three at this tip shown by this city's force and provide an one pole most advanced and sophisticated conductive element.The axle of all opposing projections shown in this embodiment extend at least with the axle general parallel orientation of the handle of device of dissecting.(overlooking) have such protuberance with or relative recess axle placement tip embodiment in, doctor can manufacture an otch then forward-reverse ground mobile dissector tip, direction is mainly parallel with axle, after retreating, then change the tissue that front travel that direction touches is adjacent.Can emphasize and/or dissect a target area by such method.In certain embodiments, some protuberance can not be parallel with axle with cracking section.In the embodiments described, most advanced and sophisticated 101 can some or all ofly be made up of concentric lamination or annealed wafer material layer in addition, can comprise, plastics, silicon, glass, glass/metal pottery, ceramic metal or pottery etc.Cracking element 105 also can some or all ofly be made by cermet material.Or be further strength China, the material of the ferrum man that this tip can be covered by insulator or conductive materials is formed.In certain embodiments, the cross section of handle can be plane, rectangle or geometric figure, or substantitally planar.In certain embodiments, handle edge smoothly can reduce the friction with import periwound skin.In some further embodiment, handle can be filled up completely by one by ferrum or plastics or other or hollow material forms.Covered wire can be equipped with, electric lead in the center of other materials described, fluids/gases pumping or suction channel, optical fiber, or insulator.

In certain embodiments, the length of handle can 10-20 centimetre.The length of handle more can be approximately 8-18 centimetre in certain embodiments.

In certain embodiments, handle plastics, it is the insulator of line or conducting element that such as politef can be used as.In certain embodiments, handle can form by the some or all of layer material by concentric lamination or annealed wafer in addition, can comprise, plastics, silicon, glass, glass/ceramic, ceramic carbon, graphite, graphite-fiberglass complex.This energy window 107 can only substantitally planar, or can have a cross section similar to the shape of a handle part, such as arc, stepped or other geometry/bending.In the embodiment shown in Fig. 1 a and 1b, energy window 107 is adjacent with protuberance 104, but expects that energy window still can keep adjacent with protuberance 104 with other seats of handle 102 or most advanced and sophisticated 101 in position in other embodiments.But if an energy window position is in handle 103, it is adjacent that this energy window is not recognized as protuberance 104.

Conduit also can comprise control electric wire to help plant running.In Fig. 1 a and 1b, hidden parts is the Tissue Lysis segment element 105 in groove between protuberance 104, and its element operates cracking tissue plane forward by straight after the energising of some electrosurgical generator.Cracking section can position in the end of conductive element.In certain embodiments, one or more such sensor such as sensor 110 and 114 can position on device.This sensor 110 and 114 can comprise any sensor that description is described at this.Other embodiments can comprise one or more sensor at other any applicable seats of device of dissecting, and described seat includes but not limited on protuberance, or on tip, or on handle.Useful sensor comprises heat sensor, photoelectricity or optical pickocff, photographing unit etc. in certain embodiments, one or more sensor may be used for monitoring close to handle distal end or most advanced and sophisticated on the electric current that can exist pass through after electrical impedance or temperature conditions.Some embodiment can comprise well one or more sensor comprising MEMS (microcomputer system) technology, such as, and the sensor of MEMS (MEMS) technology, such as MEMS gyro instrument, accelerometer etc.This kind of sensor can many places on device of dissecting, position, comprise in certain embodiments in handle.In certain embodiments, sensor 114 can comprise fiber optic component.In one embodiment, this sensor can be configured to a temperature of the tissue of sensor apparatus periphery.The temperature of one or more fluids that temperature sensor can configure in addition or sensor apparatus is adjacent, the fluid that such as tissue fluid and/or surgeon are introduced.

Temperature and resistance can be monitored or be directly connected with a microprocessor by screen, the number that this microprocessor can manipulate electrical equipment so that setting arrive or close to time change be transported to most advanced and sophisticated energy.Common instrument is widely understood, such as such as thermal sensing thermistors, and can feed back to analogue amplifier, itself and be transferred to the analog-digital converter be connected with a microprocessor.In certain embodiments, inner or external ultrasonic is weighed and also can be supplied information to feedback circuit.In one embodiment, one optional in and low frequency ultrasound transducer also can be activated with by energy delivery to most advanced and sophisticated and provide additional thermal energy and more can strengthen cracking.In certain embodiments, the visible light source of a flicker, such as a LED can be arranged on tip.This light source can come the seat of indication device through tissue and/or organ.

Second energy window 108 also can comprise in certain embodiments, and can comprise another ultrasonic energy emitter or other multiple kinds of energy discharger.Ultrasonic energy energy window 108 can position in the upper surface of device.In an alternate embodiment, energy window 108 can be omitted in expection.Merit attention, word ' energy window ' is intended to the U.S. Patent number 7,494 as can be spoken of later, 488 li of so-called amendment plane organize windows/districts, and does not need electrosurgical energy in all embodiments.In certain embodiments, its ' energy window ' can comprise other power radiation devices multiple, comprises high frequency, intense pulsed light, laser, heat, microwave and ultrasound.So-called " energy window " does not necessarily represent the region that energy can be supplied to window equably.On the contrary, the application of some energy window can comprise a series of energy delivery element or other regions.In these energy delivery elements or region, energy will provide with dispersion zone form, a small amount of or do not have energy to be provided in these regions.A ultrasonic energy window configuration may be useful in some application.Application is also allowed the damage of amendment and/or destination organization and/or heating for treatment to increase by the biology of sensing/molecule and/or chemical substance and/or (may in higher energy rank) according to piezoelectric part and/or in order to reduce the energy (in order to increase the content of target chemical substances and/or biological compound as far as possible) to tissue injury.Energy window 108 can at least substantitally planar, such as, as long as or shape is similar to a part for handle can have other shape of cross sections, arc, stepped or other geometry/bending.Some embodiment comprises a low price, replaceable, and disposable apparatus.But in the embodiment that some is multiplex, most advanced and sophisticated conductive tissue cracking element can protected or covering.Its protection or covering include but not limited to Silverglide ^tM(silver is sliding) not sticky surgery coating, platinum, palladium, gold and rhodium..Multiple different stage protective layer allow embodiment to comprise the device in multiple life-span, can extend or the tip device life-span.

In certain embodiments, most advanced and sophisticated conduction cracking componentry can from a plane or plate origin.Plane or plate have various shape, and the material that the prerequisite that its shape comes from is crossed is obtained by manufacturing technology usual way, include but not limited to additive manufacture, cutting, punching press, casting, be molded, file and sand milling.In certain embodiments, conduction cracking original paper 105 can comprise the insertion that in a handle, conducting element is attached, or its to insert be the continuity of a conducting element, its conducting element is wound around the local or all of handle.In certain embodiments, a cracking section energy conduit 111 leads RF electrosurgical energy through handle to conduction cracking element 105, and its element is relevant with part recess.In one embodiment, TURP is mainly used to by the electrosurgical energy of conduit 111.

In certain embodiments, if a selectivity finger switch position is in handle, conducting element or distribution can switch to utilize hands by bifurcated.Conducting element or distribution are directed to handle from handle and can bundle and other wire or energy delivering cables, distribution etc., and can leave proximal handle and commonly route to various generator (comprising surgery), CPU, laser and other resource be described here as insulation.In certain embodiments, described cracking section 105 can be sharp-pointed or fan-shaped or leave plate slightly to extension and will be assemblied in nose depression wherein.The described plate of composition cracking section 105 can be sharp-pointed or fan-shaped or stretch out from the nose depression of its Board position a little.

Or, in certain embodiments because cutting or electric current may not directly under contact/have during distance and also cause an impact, described cracking original paper can the recess created between protuberance 104 of setback or, can flush with protuberance 104.In the scalable embodiment that some are other, the position of conductive lysing elements can by Screw or ratchet adjustment relative to described projection.In more adjustable embodiment, the position of conductive lysing elements can by MEMS or microelectronic component adjustment relative to protuberance.Plate in certain embodiments, its thickness, can by sharpening to some extent on plate forward-facing between 0.01 millimeter and 1 millimeter.The energising efficiency at the edge cut and organized may increase along with plate sharpness.Even if but sometimes edge is blunt or do not have sharpening also can act in the clear because surgical cut electric current can cut exceed conductive edge distance more than 1 millimeter.In certain embodiments, plate thickness can from 0.001 millimeter to 3 millimeters.

In certain embodiments, described conduction cracking element also may reside in one and simply joins existing shape, and its thickness is 0.1 millimeter and 1 millimeter.Distribution can between 0.01 millimeter to 3 millimeters in certain embodiments.Such distribution can single or twoly time to be insulated, and as the insulation of plate, and can have, as surface plate spoken of identical electric current connection.In certain embodiments, the electrosurgical current for conductive lysing elements is the type of one pole " cutting " and setting and can be transported to tip lysing conductor in a continuous process, or with pulse method.Surgeon by the foot switch of Electrosurgical generator or can control electric current by the button (face forward button) on axle.The amount of cutting current can by the standard interface on change Electrosurgical generator or graduated disc.In certain embodiments, the electric current of electrosurgical energy window can pass through some interpolation gating circuit of this technology common machine outside Electrosurgical generator, makes to obtain obstructed pulse frequency further.In certain embodiments, the electric current of electrosurgical energy window can pass through some interpolation gating circuit of this technology common machine in Electrosurgical generator, makes to obtain obstructed pulse frequency further.For some embodiment, conduction cracking element is that one pole is most advanced and sophisticated, and contacts with the conducting element in handle, and its element leads to outside surgical cable, and its line leads to Electrosurgical generator.From generator, send ground connection or dispersion plate, it can be placed other place contacted with patient body, as thigh.This circuit can be controlled to be connected with gating/line by the cutting current induction system of Electrosurgical generator.In one embodiment, described tip also can be formed by the multi-layer crystal chip base material manufacture comprising bonding conducting strip and pottery.The most advanced and sophisticated manufactured materials of suitable conductive material including, but not limited to having described.

In an alternate embodiment, conducting electricity cracking element can bifurcated or be separated into even number in relative recess.Conduction cracking element can insulate and is wired into the wire of even number with bipolar versions and is connected to the bipolar outlets of aforementioned electrosurgical generator.Local or all can match bipolar electrode and be connected around the ring of the handle of handheld unit with one, it matches bipolar electrode and is positioned at the tip of energy window.Bipolar version like this can reduce the electric power that some organization need is revised in electricity consumption, particularly thicker tissue.In an alternate embodiment, described cracking segment element can be separated into radix number but allow the bipolar flow between two or more element, as can be expected in the ordinary person in this field.

Fig. 2 a shows a tissue and to dissect multiple views of a specific embodiment of device.The dissect upper surface of device of its tissue has a sensor base and a removable upper cover

Figure.2a be a tissue comprising 201, the handle 202 in a tip and a handle 203 dissect device a perspective view of an embodiment.Being positioned at, handle is base 284, and its base honor can write seat 286, and its seat can discharge sensor 289 neatly.In certain embodiments, sensor 289 can comprise optical pickocff.In certain embodiments, sensor 289 can comprise optical biosensor. and in certain embodiments, sensor 289 can comprise a Fibre Optical Sensor.

In the embodiment depicted, sensor 289 comprises a fibre optic member, and described element is arranged in optics seat.But in other embodiments, sensor 289 can be arranged in pedestal 288, and without the need to optics seat.In the embodiments described, sensor 289 comprises optical fiber biosensor.In the embodiments described, optical fiber can be given prominence to from fiber bench.Other expection embodiment in optical fiber can concordant or recessed their combine adjacent and/or surperficial.The method that optical pickocff can be had by its ordinary skill person and manufacture/obtain, the method includes but not limited to: modify suspension core photonic crystal fiber (Coscelli towards aspect ratio DNA biosensor: PNA, Sozzi, et.al.IEEEJ., SelTop. Quantum Electronics 2010,16,967-972.) and/or the nano wire suspended: processing, design, and and with nanoscale core (the sign fiber of Ebendorff, Warren, Manro; Opt.SocExpress2009,17,2646-2657.) and/or Fibre Optical Sensor, ultimate principle and application (Krohn; 2000ISA, ResearchTriangle, NC) and/or the optical fiber sensing technology (Lopez-Higuera of handbook; 2001; JohnWiley & Sons, Chichester, Britain is federal, and 2001). and/or RecentAdvancesinFiber-OpticDNA biosensor (Wang, Pang, Zhang; J. Biomedical Science and engineering, 2009,2,312-317.) and/or utilize Hydroxyphenylimidazol1,10-phenanthroline Ferrum (III) as designator research by the fluorescent fiber Opticas DNA Biology Sensors (people such as Niu, Wang; JFluoresc, 18,227-235.) and/or thiazole orange-binding peptide nucleic acid in the solution of homogeneity for detect target nucleic acid (Svanik, Westman etc.; Anal.Biochem., 2000; 281 (1), 26-35.) and/or for molecular beacon fixing in the suspension core optical fiber of the specific DNA detection (people such as Lin, Tsai; Application Optics in 2007; 46 (5), 800-806.) and/or the people such as (Nguyen, Wa Lunshi-Smith); OpticsExpress, 31Dec2012, the 20th volume the 28th), and/or the optical pickocff of micro-hollow structure formula is fast without DNA detection (Wang, Cooper, the Wang of mark; J.LightwaveTechnol.Ther.2008; 26 (17), 3181-3185.) and/or optical fiber be microarray (Walt; Chem.Soc.120Rev.1632009; 39 (1) 38-50.) and/or use the suspension core light fiber sensing (people such as Monro, Warren-Smith; OptFibreTechnol.Ther.201016 (6), 343-356.) and/or the immobilization of antibody at silica micro structure fiber: to road that is sensitive and optionally biosensor (people such as Ruan, Foo.; Opt.Express2008; 16 (22) 18514-18523.) and/or detect people such as (Hine, Chen) based on the DNA hybridization of optical fiber; Biochem, Soc.Trans (2009) 37,445-449.) and/or based on surface plasma resonance sensor (Yu, Zhang, Wang, the Shum of nanostructured waveguide; SimTech2010; STR_V11N1_09_PMG, 42-45.) and/or utilize p-Hydroxyphenylimidazo [f] 1,10-phenanthrolineFerrum (III) as designator research by the fluorescent fiber Opticas DNA Biology Sensors (people such as Shu-yanNiu; JFlouresc (2008) 18:227-235.) and/or optical dna sensor chip real time hybridization detection event (Peter etc.; The practicality of the specified ccd photographing unit of no cooling video Fresenius ' periodical AnalyticalChemistry, 2001.371 (2): 120-127) and/or for the detection of fluorescence in situ hybridization signal (Vrolijk, etc.; Cytometry, 1994.15 (1): 2-11).Such as, some reagent and/or chemicals and/or biochemistry thing can exist and/or carry to and/or from base area remove promotes sensor to use and/clear up.These reagent and/or chemicals and/or biochemistry thing can include but not limited to alcoholic solution, mercaptan, SDS (sodium lauryl sulphate), water, argon, sodium chloride, sodium bicarbonate buffer agent, EGTA (ethylene glycol tetraacetic), EDTA (ethylenediaminetetraacetic acid), sulfo group-NHSdiazirine (sulfo group SDA), PBS (phosphate buffered saline (PBS)), and/or in tween 20 (PBST), etc.Such reagent and/or chemical substance and/or biochemistry and their acquisition and use be those of ordinary skill in the art can technology, include but not limited to: United States Patent (USP) 6,593, No. 093B1, title, the detection of A group B streptococcus; U.S. Patent application publication number 2012/0228155A1 title, analyzes the electromagnetic detection of thing; U.S. Patent application publication number 2009/0186774A1 title, the microarray that septicemia detects; European patent 2526427A2, title, quick pathogen diagnosis apparatus and method.In this as reference, its entirety is quoted above.Get back to Fig. 2 a (tissue comprising 201, the handle 202 in a tip and a handle 203 dissect device a perspective view of an embodiment).Handle has a base 284, this base can hold seat 288, and this is as can fixation of sensor 289 flexibly.In certain embodiments, sensor 289 can comprise an optical pickocff.In certain embodiments, base 284 can recessed handle 202 and/or most advanced and sophisticated 201. in certain embodiments, base 284 can protrude from handle 202 and/or most advanced and sophisticated 201.In certain embodiments, base 284 can flush in handle 202 and/or most advanced and sophisticated 201.In certain embodiments, sensor 289 can comprise a Fibre Optical Sensor.In certain embodiments, sensor 289 can comprise a Photobiology sensor.In certain embodiments, seat volume 288 can be fixed on a seat.In certain embodiments, seat 288 can be moved.In certain embodiments, sensor 284 can be fixed on seat 288. in certain embodiments, and sensor 289 can separate with seat 288.Expection in an alternate embodiment, can be omitted as i volume 288.In certain embodiments, described base can expansion upper cover moving method and/or a upper cover tip.Upper cover most advanced and sophisticated 281 and selectivity move upper cover method 283 can be adjacent with base 284.The example of upper cover moving method can comprise track, groove, track, ratchet, cable, arm, line etc.In the embodiment shown, lid moving method comprises track.A part for described handle can comprise lid moving method 283 in certain embodiments.Expection in an alternate embodiment, can omit lid moving method 283.Base 284 can comprise one or more base wall 285.Base wall 285 can comprise the fluid transfer port 286 for fluid-transporting tubing.Base wall 285 can comprise the fluid extraction port 287 for fluid extraction conduit.In certain embodiments, base wall 285 can comprise one or more port 286 and/or 287.Upper cover 280 can move along upper cover moving method 283 and can by control line switch in figure 1 c.Upper cover can be moved by motor in certain embodiments.The rear end of upper cover 282 can be fixed with upper cover 280. in certain embodiments, another part of the fixing device and self and tissue are dissected of upper cover 282 rear end discord upper cover itself is connected, in certain embodiments, base 284 and/or base wall 285 can hold a temperature control method 295, and its methodological function is in order to the temperature in adjusting base 284 and in upper cover 280.Temperature control method 295 can comprise a such as heater, a peltier cooler, a heat pump etc.Temperature control method 295 can be heated by the fluid that port 286 enters.The bodily tissue that temperature control method 295 can be used to use device of dissecting to win during heat tissue and/or other fluids are such as performed the operation in addition and/or fluid.In certain embodiments, temperature control method 295 can promote and/or suppress some in order to use chemical reaction and/or the chemical bond amendment of some biomaterial of sensor 289 sensing.In certain embodiments, base 284 and/or base wall 285 can hold hybrid element 296. in certain embodiments, and temperature control method 295 can comprise a resistance heater.In contemplated embodiments, heater 295 can comprise one and draws together thin film resistor and/or piezoelectricity heating means and/or have the miscellaneous equipment heating fluid capacity.In certain embodiments, hybrid element 296 can comprise a propeller by an electro-motor running.In certain embodiments, hybrid element 296 can comprise one or more wing flap compared with inert polymerization plastics, and this wing flap is positioned at a pillar operated by electro-motor.Other Available Materials of wing flap can comprise polymer, metal, pottery etc.In another embodiment, hybrid element 296 can comprise one by vibration magnet rotors independent stirring rod.In the embodiment of an expection, one group of independent port initial sum can end at base 284, and can pass through a tubes connection.This tubes connection is in a piezoelectric pump and/or other fluid motor and/or other fluid drives method.In the embodiment comprising one or more this kind of additional ports, these one or more ports can be arranged on the opposing end portions of base 284, can be applied to whole base 284 more equably when one or more fluids are carried and/or when applying vacuum.In an alternate embodiment, temperature control method 295 and/or hybrid element 296 can be omitted in expection.One or more sensor 278 and/or 279 can be positioned at base 284 li.In certain embodiments, one or more sensor 278 and/or 279 can be positioned at base wall 285 and/or lid 280.Sensor 278 and/or 279 can comprise the object lesson of any discussed sensor relevant to sensor 210 and/or 214.Sensor 278 and/or 279 can report that the base area 284 li of nano-sensor 289 and/or the situation of surrounding and/or situation change.In certain embodiments, sensor 278 and/or sensor 279 can comprise a photographic head.In certain embodiments, sensor 278 and/or sensor 279 can comprise an optical fiber for and/or optical fiber be photographic head and/or CCD photographic head and or other photographic head.

In certain embodiments, one or more electromagnetism delivery element 277 can the tip of position and/or upper cover 280 and/or upper cover 281 most advanced and sophisticated in base 284.Other embodiments can comprise one or more electromagnetism delivery element.Its element organizing any suitable seat on device of dissecting, can include but not limited to sensor 289 or seat 288..Useful electromagnetism delivery element can include but not limited to: LED, laser instrument, fiber optics, filament, photoelectric material, RF transmitter etc.The transmitting of electromagnetism can be absorbed by the emission spectra of the biomolecule on chemicals and/or sensor and/or base area and/or reverberation and/or chemicals and/or biomolecule in certain embodiments, and/or further product can be detected with sensor 278 and/or sensor 279.

In one embodiment, lid 280 and/or base 184 can be arranged to reflecting electromagnetic radiation.Reflecting electromagnetic radiation and/or there is minute surface character sensor 278 and/or 279 can be allowed for detecting electromagnetic radiation.. in certain embodiments, lid 280 and/or base 284 comprise the film coating of a covering material.In certain embodiments, material can be plastics and/or molded polymeric and/or crystal and/or glass and/or metal etc.In certain embodiments, lid 280 and/or base 284 comprise one deck aluminum.. in certain embodiments, aluminum film comprise a shielded aluminum and/or enhancing aluminum and/or by ultraviolet enhancing aluminum (maker can be EdmundOptics, Barrington, New Jersey, the U.S.).In the embodiment depicted, cover 280 and can comprise plastics.In other embodiments, cover 280 materials comprised to include but not limited to: polymer, quartz, glass, carbon-based material, silicate and/or metal.

This conduit can also containing electric control wire to help equipment operating.In figure part be not directly exposed to view 2a and 2b and be positioned at protuberance 204 emphasize out groove be conductive tissue cracking element 205.This element makes device operate forward when borrowing electrosurgical generator energy to operate, and dissolves tissue plane.This cracking section can be positioned at the end of conducting element.In certain embodiments, one or more sensor such as sensor 210 and 214 can be arranged on device.Sensor 210 and 214 can comprise any sensor described in this manual.In certain embodiments, sensor 210 and/or sensor 214 can comprise photographic head.In certain embodiments, sensor 210 and/or sensor 214 can comprise optical fiber and/or fiber optic camera machine and/or ccd video camera and/or other photographing unit. other embodiment can tissue dissect what has a high regard for suitable seat on comprise one or more sensor, include but not limited on protuberance, on tip, and on handle.The sensor come in handy comprises heat sensor, photoelectricity or optical pickocff, photographing unit etc.In certain embodiments, one or more sensor can be used monitor close to handle distal end or most advanced and sophisticated on the electric current that can exist pass through after electrical impedance or temperature conditions.Some embodiments can also comprise one or more sensor in conjunction with MEMS (MEMS) technology, such as MEMS gyro instrument, accelerometer etc.Such sensor can be placed in tissue and to dissect many places on device, comprises the seat in handle in certain embodiments.In certain embodiments, sensor 214 can comprise fiber optic component.In one embodiment, sensor can be configured to the temperature of the adjacent tissue of sensing apparatus.Temperature sensor can be configured to the fluid sensing one or more neighboring devices in addition, such as tissue fluid and/or the fluid introduced by surgeon.

In certain embodiments, one or more electromagnetism delivery element 215 can be positioned on above most advanced and sophisticated or handle.Other embodiment can comprise one or more electromagnetism delivery element dissecting on any other suitable seat of device, and this element includes but not limited at jut, or on tip, and on described handle.Useful electromagnetism conveying element comprises: LED, laser instrument, optical fiber, long filament, photoelectric material, RF transmitter etc.As shown in Figure 2 a, lever 203 can comprise one or more port.Various conduit can pass through this port.If in certain embodiments conveniently needed for, multiple conduit can be bundled in together.Such as, in the embodiment described, a power transfer conduit harness 298 can be provided.This harness can comprise a cracking section energy conduit 211 and an energy window conduit 212.In addition, miscellaneous conduit harness 299 can be provided.Mixed item pipeline harness 299 can comprise other conduits various, such as, for one or more conduit as sensor 210 and 214, for the conduit of one or more electromagnetism delivery element 215, for fluid transfer port 216 ,/the conduit of vacuum ports 217 of and/or bleeding.In addition, miscellaneous conduit harness can comprise one or more additional conduits, such as one or more additive fluid delivery conduit.This conduit can carry a liquid or gas to the port 286 of device base 284 li of dissecting.Miscellaneous conduit harness 299 may further include one or more fluid extraction conduit (port 287 from base 284).This extraction conduit is used for withdrawn fluid (liquid or gas), guides fluid to an independent fluid/chemicals sensor.

This fluid delivery catheter (being directed to port 286) can be configured to conveying, such as, and buffer agent, cleaning agent, quencher, reagent, biologic artifact, inert compound, gas.The fluid being flowed to port 286 by delivery conduit can be increased energy, such as, heat, and ultrasonic energy supply can comprise detergent, antibody, medicine etc.

Fluid extraction conduit (from port 287) not only can be used for extracting the unwanted fluid of health, can also be used for removing the fluid being incorporated into port 286 by fluid delivery catheter a wash circuit.This fluid is used for originally, and such as, wash and/or sterilize some biological tissues and/or tissue are dissected the parts of device.Fluid extraction conduit (from port 287) can also carry out withdrawn fluid in order to external analysis.Some embodiment can be configured to provide bubble so that user distinguishes the various fluids that the fluid extraction conduit from port 287 takes out to many group different fluid.

In certain embodiments, vibrating method 270 can be arranged in handle.Other embodiment can comprise one or more vibrating method at any suitable seat on device of dissecting, and its seat includes but not limited on jut or tip, and on described handle.Suitable vibrating method can comprise piezoelectric, ultrasonic motor and stator, piezo-activator, and vibrations motor, such as, be arranged on the eccentric weight on gear.It is ultrasonic that some vibrating method can be configured to launch in 20-40 kilohertz range.Other vibrating methods can comprise the electromagnet actuators of operating frequency range in 150-400 hertz.In certain embodiments, one or more vibrating method may be used for providing additional power, to dissect passing through of device with convenient tissue.In certain embodiments, one or more vibrating method can be used for reducing on electrosurgery parts or other impurity of dissecting on device parts.In another embodiment, vibrating method directly or indirectly can be connected to one or more described cracking section.Some vibrating method can help to reduce and/or remove foreign material.In certain embodiments, vibrating method can or be used in operation, help the movement of device between tissue of dissecting in addition.In the described embodiment, expect that low-frequency vibrating method can contribute to described movement especially.In addition, also can to help described movement in the handle close to device of dissecting vibrating method position.On the contrary, vibrating method is positioned at the accumulation that can be particularly useful in the most advanced and sophisticated upper impurity of prevention close to most advanced and sophisticated and/or the higher vibration frequency method of use.

Fig. 2 d, c illustrate that tissue is dissected device and be moved and reveal the upper cover 280 showing base.

Fig. 2 f, e illustrate that tissue device of dissecting is distally mobile to cut out and/or sealed base with lid 280.

The viewgraph of cross-section of Fig. 2 g upper cover 280 embodiment, comprises the groove 291 described in and a protuberance 292.Groove 292 can be used to guide fluid in upper cover 280, so that fluid-mixing and/or guiding fluid take the seat in base or in upper cover to needs cleaning side and/or guiding fluid to sensor seat and/or the fluid in certain temperature range.As described in similar, protuberance 292 also can be used to guide fluid to one or more described seat and/or in order to a concrete use stirred fluid.

Fig. 2 h is the viewgraph of cross-section of base 284 embodiment, comprises the groove 293 described in and a protuberance 294.Groove 293 can be used to guide fluid in base 284, so that fluid-mixing and/or guiding fluid take the seat in base or in upper cover to needs cleaning side and/or guiding fluid to sensor seat and/or the fluid in certain temperature range.As described in similar, protuberance 294 also can be used to guide fluid to one or more described seat and/or in order to a concrete use stirred fluid.In certain embodiments, upper cover 280 and base 284 can create a common space when upper cover 280 belongs to closed condition.In certain embodiments, upper cover protuberance 291 can with base groove 293 or base extension 294 joint effect fluid to a kind of desirable state.

In Fig. 2 g and/or 2h, in base 284 and/or upper cover 280 show in inner face, such as to arrange one or more groove 291 and 293, to be conveyed through port 286 fluid to one or more desirable seat.In certain embodiments, groove can be configured to promote fluid chemical field and/or guide fluid to needing clean region and/or sensor region.In base 284 and/or upper cover 280 show in inner face, such as to arrange one or more groove 292 and 294, to be conveyed through port 286 fluid to one or more desirable seat.In certain embodiments, groove can be configured to promote fluid chemical field and/or guide fluid to needing clean region and/or sensor region.In certain embodiments, most protuberance can form a groove, in other embodiments one or more groove can upper cover and or base surface formed.

Figure .2e institute show and closes upper cover 280, and the space promotion formed in the upper cover 280 that fluid can be closed again is cleaned.Close upper cover 280 and can also promote isolation biological tissue and/or fluid.Such as, close upper cover 280 can allow to analyze tissue and/or fluid when not infected by other biological tissue and fluid.Cleaning to use the angle of different seat and/or sensor and/or various angle to carry out further.In Fig. 2 i the configuration that shows can mainly in order to catch tissue for analyzing and/or fluid, but some embodiment can be configured to seat 188 and tend to organize the rear end of device of dissecting, and makes this seat towards (tending to) fluid port 286 to promote the cleaning of sensor 289.

In order to the fluid delivery ports 286 of fluid conveying with can also be used to conveying in order to the fluid extraction port 287 of fluid extraction and/or remove fluid, such as, include but not limited to, reagent and/or analyze thing and/or eluent and/or eluate.In certain embodiments, from fluid delivery ports 286 fluid conveying and or from fluid extraction port 287 fluid extraction can with a pump and/or other tubes connection (this tubes connection is connected and the conduit of fluid delivery ports 286 and fluid extraction port 287 in one or two) in a circuit.This circuit is used for recirculation and/or heating and/or insulation and/or mixing and/or add the material that reagent and/or removing reagent and/or other comes from upper cover 280 and/or base 284.In certain embodiments, to dissect outside device at tissue and to connect and the pump of circuit of conduit between port 287 and port 286 can be used for mobile fluid.The fluid space that upper cover 280 and base 284 (having spacial element) provide can with to enter and/or Fluid Volume for port 286 and/or 287 conduit is estimated.Described estimator can compare with the amount that computer-aided design calculates.

The side-looking of the embodiment that figure .2i presents before being inside figure .2a, shows location, a seat and/or seat projected state (comprising a nano-sensor) makes this seat can allow have with the tissue of some processes or fluid the example contacted.Described tissue device of dissecting can comprise an executor 290.Executor 290 can comprise a motor in certain embodiments.In certain embodiments, executor 290 can comprise one or more described motor, such as screw drive motor, gear motor, hydraulic motor etc.In certain embodiments, executor 290 can comprise gear-box, motor control circuit, monitor, remote control equipment etc.In certain embodiments, executor 290 can be controlled by steel wire and/or spring or move.In certain embodiments, executor 290 can be manually controlled or move.In certain embodiments, executor 290 can be omitted.In certain embodiments, seat 288 can be configured to manually promote or tilt.In certain embodiments, seat 288 can be configured to and have the arrangement of the different angles of several fixed number between handle 202 and/or base.In other embodiment, seat 288 can be configured to and have the arrangement of numerous different angles between handle 202 and/or base.

For carry the method 297 of ultrasonic energy can be positioned at the base wall 285 li of base 284 li/.Ultrasonic method 297 can be configured to, such as, and hot fluid: contribute to clean one or more parts of device of dissecting of organizing and comprise such as base 284: the mixing helping reagent and/or organic chemicals and/or biomolecule; Biomolecule and/or other material and acceptor and/or sensor is helped to fix; Help to remove biomolecule and/or other materials from acceptor.In the embodiments described, ultrasonic method comprises piezoelectric ceramics.This piezoelectric ceramics can be measured and be approximately 2 millimeters * 2 millimeters * 4 millimeters in certain embodiments.In an alternate embodiment, ultrasonic method 297 can be omitted in expection.In certain embodiments, piezoelectric ceramics is made by lead titanate piezoelectric ceramics that (this material can be referred to as PZT8 or PZT4, be manufactured in Micromechatronics (micro machine), state university, Philadelphia) and can be operated by 2-5 watt between 10-20 volt.And/or can be configured to shake between 300-500 KHz.In certain embodiments, piezoelectrics can comprise quartz and/or Barium metatitanate. and/or membrane polymer Kynoar.In certain embodiments, any dimensional measurement of ultrasonic method is all between 1 millimeter to 20 millimeters.Some embodiment can comprise most ultrasonic method.In certain embodiments, ultrasonic method can be configured in two or more phase cross surface, such as scheme a upper surface of a part of ultrasonic method 297 position and handle 202 in the embodiment shown in .2b, another part position is in the base wall 285 crossing with handle 202 upper surface.In the embodiment shown, wall 285 in the upper surface of handle 202 with the substantially angle of intersection of 90 degree.

Figure.In the embodiment that 2i limits, sensor 289 can be made to increase and/or change contact and/or friction in one or more angle at seat 288 and/or sensor 289 position when upper cover is in open mode, the tissue of promotion sensor 289 and process and/or fluid have a desirable reaction.

In the embodiment of figure shown in .2j, can ideally or at least suitable applying for some at least substantially parallel with handle 202 angle seat 288 and/or sensor 289 position.

In certain embodiments, one or more suction/vacuum ports 217 can be provided in tip or far-end handle.Port can be connected to a vacuum; Vacuum can comprise a Beng Huoyige negative pressure chamber or a syringe at fluid conduit systems afterbody.Other embodiments can comprise one or more suction/vacuum ports.Its seat can organize any other place be applicable to of device of dissecting again, comprises and being singly not limited to: on protuberance or on tip and on handle.In certain embodiments, a fluid delivery ports 216 can be provided.In certain embodiments, fluid delivery ports can connect and pump or high-pressure fluid.In certain embodiments, port for good and all can be opened when making primer pump or high-pressure liquid system fluid and can be transferred through its opening.In other embodiments, port can be closed and optionally open to make conveyance fluid.Other embodiments can comprise one or more fluid port.Any other place be applicable to of device of dissecting can organized in its seat, comprises and being singly not limited to: on protuberance or on tip and on handle.Useful fluid port can be dissected device at tissue, and polymer line, flexible pipe etc. comprise passage.The fluid deriving from outlet can comprise ionic liquid, such as salt, medicine (including but not limited to antibiotic, anesthetis, antitumor drug, antibacterial etc.), not ionic liquids, with or gas (including but not limited to nitrogen, argon, air etc.), in certain embodiments, fluid can under high pressure or injected.Although what be worth proposition is that these elements (216 and 217) are not shown in other all figure, any embodiment as herein described can comprise one or more described element.

In the embodiment shown, 218 represent an antenna, and such as one is configured to transmission information to the RFID label tag of a receptor or Bluetooth antenna.Comprise in the embodiment of a RFID label tag at antenna 218, described RFID label tag can comprise a RFID transponder.Described RFID label tag can comprise a passive label in other embodiments.Although it should be noted that antenna 218 is not shown in other all figure, any embodiment as herein described can comprise one or more described element.Other embodiments can comprise one or more antenna on any applicable seat of tissue dissector, and its seat includes but not limited on protuberance, or on most advanced and sophisticated and handle.Comprise in the embodiment of a RFID transponder at antenna 218, this transponder can comprise a microwafer, and such as one can rewrite the microwafer of storage.In certain embodiments, described mark size can approximately be less than several millimeter.In certain embodiments, a card reader can create an ac magnetic field, and this magnetic field can start described antenna, such as a RFID transponder, and can send data by frequency modulation.In the embodiment comprising one or more RFID label tag (or other antennas), the seat of RFID label tag or other antennas can by a high-frequency alternating current Magnetic oriented.Can draw with the 3D of object and contact in described seat.In one embodiment, this card reader can produce an ac magnetic field.In the described embodiment, alternating electromagnetic field can be shortwave (13.56 megahertz) or ultrashort wave (865-869 megahertz) frequency.What come in handy can see No. 2007/0225550, U.S. Patent application relative to the example of the system and method for the operating theater instruments in patient body for mapping/following the trail of, be entitled as " system and method relative to the 3D of operating theater instruments in patient body follows the trail of ", at this, its full content be incorporated herein by reference.

In other embodiments, antenna 218 can comprise a Bluetooth antenna.In the described embodiment, the signal intensity of perception from Bluetooth antenna 218 can be configured at the multiple corresponding bluetooth receiver of known location, and these data of triangulation in case by the signal framing from Bluetooth antenna 218 thus the tissue be positioned in patient body is dissected device.Other embodiments can be configured to use based on angle, electronic location Technology and equipment, to be positioned at antenna 218.Some embodiment can comprise use beam antenna, and it can be used for the precision increasing location.Other embodiments can comprise and use other to have hardware for locating and/or signal, such as wireless and cellular signals.

One or more receiver can be configured to the signal receiving label.By assessing the signal intensity of such as multiple receiver, the distance between receiver can be estimated.By the distance estimated, in patient body and/or the dissect seat of device of the tissue at an organ or the concrete seat of local one of other operations can be determined.In certain embodiments, RFID or other positioners can be connected with a display screen the general seat making surgeon can see at least one label, to dissect device corresponding seat in patient body to understand tissue.

Most advanced and sophisticated 201 can be connected with a robot arm in certain embodiments.In certain embodiments, most advanced and sophisticated 201 can be connected with a robot arm with a part for handle 202.In certain embodiments most advanced and sophisticated 201 and/or a part for handle 202 and/or a part for lever 203 can be connected with a robot arm.In certain embodiments, robot arm can comprise one or more motor, such as screw drive motor, gear motor, hydraulic motor etc.In certain embodiments, robot arm system can comprise gear on worm, video camera, circuit for controlling motor, monitoring, remote control equipment, light source, touch screen etc.

Fig. 2 k and 2L demonstrates tissue and to dissect the alternative embodiment of device, and wherein that upper cover 280 comprises one or more opening (280L of 280k and Fig. 2 L of Fig. 2 k).The embodiment that the element that all the other Fig. 2 K with 2L show can demonstrate with Fig. 2 a-2j is similar or identical.

As shown in Fig. 2 k, at least one opening 280K is present in upper cover 280.In certain embodiments, upper cover 280 can be configured at least fully to cover (except opening 280K) space and make the vacuum applied by port 287 that 280K can be allowed to have suction.In shown embodiment, opening 280K can be circular.In shown embodiment, opening 280K diameter can be approximately 1.5 millimeters.In other embodiments, the diameter range of opening 280k can be from about 100 microns to about 100 millimeters.In the embodiment of other expection, opening 280k can have various geometry, includes but not limited to square, rectangle and/or polygon.In the described embodiment, sensor 289k can comprise nano-sensor.In certain embodiments, lid 280 can be configured in the inner space at least generally sealed, thus the vacuum that port 287 is applied can cause opening 280K to have suction.In the embodiments described, seat 288 can lifting and or decline, with allow sensor 289k close to and/or away from opening 280k so as to increase and/or reduce with pass through to be inhaled into after port 287 applies vacuum in upper cover 280 with the contacting of the tissue in base 284 and/or fluid.Do not show at this view the executor still spoken of in disclosure book other places and can be configured to energy sliding seats 288 and/or sensor 289K.When the fluid after applying suction by port 287, outside upper cover 280 and/or tissue can be forced/pull to the EDGE CONTACT with opening 280K, these materials can be sucked into opening 280K when organizing device of dissecting have motion or do not move further.Can to contact with sensor 289 and analyzed at dissect fluid beyond device and/or tissue of tissue before.Do not show at this view the element in base and upper cover still spoken of in disclosure book other places can be configured to move, stir and/or change the temperature of the fluid in base and upper cover to contribute to cultivating and/or analyzing and/or analyze again and/or clean and/or safeguard.The fluid entering upper cover 280 can be included but not limited to by several factors drive and restriction: openings of sizes, outside environment, organizational environment, and/or from the normal pressure of the fluid of fluid delivery ports 286 and/or the vacuum from fluid extraction port 287.

The handle of Fig. 2 K comprises antenna 218K further.In the embodiments described, 218K represents an antenna being configured to signal to receiver.In certain embodiments, antenna 218 can comprise any antenna package in this book described by other places containing such as, at this any antenna relevant to antenna 218.Comprise in the embodiment of a RFID label tag at antenna 218, RFID performance can comprise a RFID transponder.

As shown in figure 2l, at least one opening 280L is present in upper cover 280.In the embodiments described, opening 280L can be circular.In the embodiments described, opening 280L approximately has the diameter of 1.5 millimeters.In the embodiment described by Fig. 2 L, the allowing at least partially of sensor 289L can be given prominence to tissue and to be dissected the part of device, enters the space beyond device of dissecting to carry out biological tissue and/or liquid perception and/or to take sample and/or side-looking.In other fact Examples, opening 280L diameter can approximately from 100 microns to 100 millimeters.

Various geometry can be had at the embodiment split shed 280L of other expection, include but not limited to square, rectangle and/or polygon.Such as, the opening of rectangle can allow to be pinioned sensor by band and passes through opening.The sensor 289L helped by band can by opening 280L, as shown in figure 2l.The band arrived from the side can similarly be a line.In certain embodiments, the material of sensor and/or described band is flexible.Pliability contributes to the integrity when sensor enters outside environment by opening (above cover and/or organize and dissect on device).In this process tissue dissect device can when having or carry out without when affecting.In the embodiments described, sensor 289L is a nano-sensor.In certain embodiments, upper cover 280 can be configured at least roughly close out after an inner space makes port 287 apply vacuum and opening 280L can be allowed to have suction.In Fig. 2 L, at least a part for sensor can be given prominence to tissue and to be dissected the opening 280L of device, allows its part contact dissect tissue outside device and/or fluid.In the embodiments described, seat 288 can lifting and or declining, to allow sensor 289L by opening 280L to return tissue outside upper cover and/or base and/or tissue dissect device of the inside of the adjacent upper cover of base and/or contact and/or fluid.Do not show at this view the executor still spoken of in disclosure book other places and can be configured to energy sliding seats 288 and/or sensor 289L.The fluid entering upper cover 280 can be included but not limited to by several factors drive and restriction: openings of sizes, outside environment, organizational environment, and/or from the normal pressure of the fluid of fluid delivery ports 286 and/or the vacuum from fluid extraction port 287.Sensor 289L can receive and/or send one or more signal from/to a datatron backwash.Sensor 289L can by transfer in the outside of upper cover and/or inside upper cover in this process.Can be cleaned when sensor 289L is retracted in upper cover, as herein other local are spoken of.

Sensor 289L can be connected with an antenna, its antenna can receive when sensor 289L transfers outside upper cover 280 and/or send one or more from/to the signal of datatron.Or in addition, can local store by the data of sensor 289L analysis tissue and/or fluid and send later.Such as, the data obtained after analysis can send with signal after 289L is retracted in upper cover 280 again.Alternatively, described signal can send after surgery.Under such method, signal need not use wireless transmission.Some embodiment can be configured to local to store, a bin afterwards, such as USB can from tissue dissect device take out then by its information stored in computer to analyze.

The handle of Fig. 2 L comprises an antenna 218L.In the embodiments described, 218L represents the antenna that is configured to send signal to receiver.In certain embodiments, antenna 218L can comprise any antenna spoken of herein, comprises any antenna related with antenna 218L.Comprise in the embodiment of a RFID label tag at antenna 218L, described RFID label tag can comprise a RFID transponder.

At this as shown in Figure 2 B (before the fragmentary, perspective view shown in Fig. 2 a), most advanced and sophisticated 101 can by non-conductive and thermal conductivity low material form, the such as plastics of porcelain, epoxy resin, pottery, glass-ceramic or various politef.Or tip can be made up of metal or part or all of insulating conducting material.The part noticing relative projection and opposing recesses can not be seen completely from this visual angle.In certain embodiments, most advanced and sophisticated relatively recessed part is conductive tissue cracking element 205 (usually all can't see at multiple visual angle).This element can have any geometry, comprises a thin columned line; Tissue Lysis element can be plate shape or planar shaped or linear.This element by non-fusible under any operating condition and can not toxic residua metal or alloy form.Ideal material can include but not limited to steel, nickel, alloy, palladium, gold, tungsten, silver, copper and platinum.Thus metal oxidizedly can stop electric current and its function.In an alternate embodiment, the geometry of tip region can comprise not along the protuberance (from depression angle) of the axis of handle; In described alternative embodiment, some can be configured to evil spirit and all spends and/or comprise disposable tip and make a surgeon can change suitable tip according to concrete operation.Or in addition, one or more tip can be disposablely make a surgeon to lose after surgery most advanced and sophisticated then to install a new tip when the continuity of next one operation or current procedure.

The upper surface put can have an energy window 207. in certain embodiments, and energy window 207 comprises the window of an electrosurgical energy.In an alternate embodiment, energy window 207 can be omitted in expection.It should be noted that word ' energy window ' is intended to the U.S. Patent number 7,494 as can be spoken of later, 488 li of so-called amendment plane organize windows/districts, and do not need electrosurgical energy in all embodiments.In certain embodiments, its ' energy window ' can comprise other power radiation devices multiple, comprises high frequency, intense pulsed light, laser, heat, microwave and ultrasound.So-called " energy window " does not necessarily represent the region that energy can be supplied to window equably.On the contrary, the application of some energy window can comprise a series of end or other regions.In these ends or region, energy will provide with dispersion zone form, a small amount of or do not have energy to be provided in these regions.This is configured with and helps some application: it can allow the amendment in some particular organization region in dispersion zone.These region inner tissues can without any amendment, or the degree of amendment is few.Due to the restoration methods of some tissue, this configuration may apply some advantage for some.In certain embodiments, second energy window can also be had, and radio frequency electrosurgical energy emitting device or other multiple kinds of energy discharger can be comprised.

The TURP energy that breaks can come conduit 211 and/or 212.

In one embodiment, tip size is approximately wide is 1 centimetre, and thickness is 1 to 2 millimeters.The tip of 5 to five/1sts times of these sizes also can be useful.In some veterinary embodiment, the tip of to 20/10ths times of the size before mentioned also can be useful.In certain embodiments, this tip can be independent parts, and this tip is fixed on handle by multiple method, such as fastening mechanism, fit, plastics sonic welded etc.Or in other embodiments, tip can be the part for handle or the continuity of handle made with similar iron material.In certain embodiments, most advanced and sophisticated also can by being insulation and the material of conductor low in calories forms; Such as, porcelain, pottery, glass ceramics, plastics, various politef, carbon, graphite and graphite-fiberglass complex.

In certain embodiments, tip can be made up of the carrier matrix of megohmite insulant (such as, pottery or glass material, such as aluminium oxide, zirconium oxide).Cracking section energy conduit 211 is connected with conductive element, so that the electric cracking element 205. of the recess leading from the RF electrosurgical energy of Electrosurgical generator to handle 202 to protuberance 204 in certain embodiments, protuberance can comprise bud shape protuberance.There are four opposing projections recess relative to three at this tip shown by this city's force and provide an one pole most advanced and sophisticated conductive element.The axle of all opposing projections shown in this embodiment extend at least with the axle general parallel orientation of the handle of device of dissecting.(overlooking) have such protuberance with or relative recess axle placement tip embodiment in, doctor can manufacture an otch then forward-reverse ground mobile dissector tip, direction is mainly parallel with axle, after retreating, then change the tissue that front travel that direction touches is adjacent.Can emphasize and/or dissect a target area by such method.In certain embodiments, some protuberance can not be parallel with axle with cracking section.

In the embodiments described, most advanced and sophisticated 201 can some or all ofly be made up of concentric lamination or annealed wafer material layer in addition, can comprise, plastics, silicon, glass, glass/metal pottery, ceramic metal or pottery etc.Cracking element 205 also can some or all ofly be made by cermet material.Or be further strength China, the material of the ferrum man that this tip can be covered by insulator or conductive materials is formed.In certain embodiments, the cross section of handle can be plane, rectangle or geometric figure, or substantitally planar.In certain embodiments, handle edge smoothly can reduce the friction with import periwound skin.In some further embodiment, handle can be filled up completely by one by ferrum or plastics or other or hollow material forms.Covered wire can be equipped with, electric lead in the center of other materials described, fluids/gases pumping or suction channel, optical fiber, or insulator.

In certain embodiments, handle plastics, it is the insulator of line or conducting element that such as politef can be used as.In certain embodiments, handle can form by the some or all of layer material by concentric lamination or annealed wafer in addition, can comprise, plastics, silicon, glass, glass/ceramic, ceramic carbon, graphite, graphite-fiberglass complex.This energy window 207 can only substantitally planar, or can have a cross section similar to the shape of a handle part, such as arc, stepped or other geometry/bending.In the embodiment shown in Fig. 2 a and 2b, energy window 207 is adjacent with protuberance 204, but expects that energy window still can keep adjacent with protuberance 204 with other seats of handle 202 or most advanced and sophisticated 201 in position in other embodiments.But if an energy window position is in handle 203, it is adjacent that this energy window is not recognized as protuberance 204.

Conduit also can comprise control electric wire to help plant running.In Fig. 2 a and 2b, hidden parts is the Tissue Lysis segment element 205 in groove between protuberance 204, and its element operates cracking tissue plane forward by straight after the energising of some electrosurgical generator.Cracking section can position in the end of conductive element.In certain embodiments, one or more such sensor such as sensor 210 and 214 can position on device.This sensor 210 and 214 can comprise any sensor that description is described at this.Other embodiments can comprise one or more sensor at other any applicable seats of device of dissecting, and described seat includes but not limited on protuberance, or on tip, or on handle.Useful sensor comprises heat sensor, photoelectricity or optical pickocff, photographing unit etc. in certain embodiments, one or more sensor may be used for monitoring close to handle distal end or most advanced and sophisticated on the electric current that can exist pass through after electrical impedance or temperature conditions.Some embodiment can comprise well one or more sensor comprising MEMS (microcomputer system) technology, such as, and the sensor of MEMS (MEMS) technology, such as MEMS gyro instrument, accelerometer etc.This kind of sensor can many places on device of dissecting, position, comprise in certain embodiments in handle.

In certain embodiments, sensor 214 can comprise fiber optic component.In one embodiment, this sensor can be configured to a temperature of the tissue of sensor apparatus periphery.The temperature of one or more fluids that temperature sensor can configure in addition or sensor apparatus is adjacent, the fluid that such as tissue fluid and/or surgeon are introduced.

In certain embodiments, one or more electromagnetism conveying element 215 can be positioned on tip or handle.Other embodiment can comprise one or more electromagnetism delivery element on tissue dissects any other suitable seat of device, and this element includes but not limited at jut, or on tip, and on described handle.Useful electromagnetism conveying element comprises: LED, laser instrument, optical fiber, long filament, photoelectric material, RF transmitter etc.

Second energy window 208 also can comprise in certain embodiments, and can comprise another ultrasonic energy emitter or other multiple kinds of energy discharger.Ultrasonic energy energy window 208 can position in the upper surface of device.In an alternate embodiment, energy window 208 can be omitted in expection.Merit attention, word ' energy window ' is intended to the U.S. Patent number 7,494 as can be spoken of later, 488 li of so-called amendment plane organize windows/districts, and does not need electrosurgical energy in all embodiments.In certain embodiments, its ' energy window ' can comprise other power radiation devices multiple, comprises high frequency, intense pulsed light, laser, heat, microwave and ultrasound.So-called " energy window " does not necessarily represent the region that energy can be supplied to window equably.On the contrary, the application of some energy window can comprise a series of energy delivery element or other regions.In these energy delivery elements or region, energy will provide with dispersion zone form, a small amount of or do not have energy to be provided in these regions.A ultrasonic energy window configuration may be useful in some application.Application is also allowed the damage of amendment and/or destination organization and/or heating for treatment to increase by the biology of sensing/molecule and/or chemical substance and/or (may in higher energy rank) according to piezoelectric part and/or in order to reduce the energy (in order to increase the content of target chemical substances and/or biological compound as far as possible) to tissue injury.Energy window 208 can at least substantitally planar, such as, as long as or shape is similar to a part for handle can have other shape of cross sections, arc, stepped or other geometry/bending.

Some embodiment comprises a low price, replaceable, and disposable apparatus.But in the embodiment that some is multiplex, most advanced and sophisticated conductive tissue cracking element can protected or covering.Its protection or covering include but not limited to Silverglide ^tM(silver is sliding) not sticky surgery coating, platinum, palladium, gold and rhodium..Multiple different stage protective layer allow embodiment to comprise the device in multiple life-span, can extend or the tip device life-span.

In certain embodiments, most advanced and sophisticated conduction cracking componentry can from a plane or plate origin.Plane or plate have various shape, and the material that the prerequisite that its shape comes from is crossed is obtained by manufacturing technology usual way, include but not limited to additive manufacture, cutting, punching press, casting, be molded, file and sand milling.In certain embodiments, conduction cracking original paper 205 can comprise the insertion that in a handle, conducting element is attached, or its to insert be the continuity of a conducting element, its conducting element is wound around the local or all of handle.In certain embodiments, a cracking section energy conduit 211 leads RF electrosurgical energy through handle to conduction cracking element 205, and its element is relevant with part recess.In one embodiment, TURP is mainly used to by the electrosurgical energy of conduit 211.

In certain embodiments, if a selectivity finger switch position is in handle, conducting element or distribution can switch to utilize hands by bifurcated.Conducting element or distribution are directed to handle from handle and can bundle and other wire or energy delivering cables, distribution etc., and can leave proximal handle and commonly route to various generator (comprising surgery), CPU, laser and other resource be described here as insulation.In certain embodiments, described cracking section 205 can be sharp-pointed or fan-shaped or leave plate slightly to extension and will be assemblied in nose depression wherein.The described plate of composition cracking section 205 can be sharp-pointed or fan-shaped or stretch out from the nose depression of its Board position a little.

Or, in certain embodiments because cutting or electric current may not directly under contact/have during distance and also cause an impact, described cracking original paper can the recess created between protuberance 204 of setback or, can flush with protuberance 204.In the scalable embodiment that some are other, the position of conductive lysing elements can by Screw or ratchet adjustment relative to described projection.In more adjustable embodiment, the position of conductive lysing elements can by MEMS or microelectronic component adjustment relative to protuberance.Plate in certain embodiments, its thickness, can by sharpening to some extent on plate forward-facing between 0.01 millimeter and 1 millimeter.The energising efficiency at the edge cut and organized may increase along with plate sharpness.Even if but sometimes edge is blunt or do not have sharpening also can act in the clear because surgical cut electric current can cut exceed conductive edge distance more than 1 millimeter.In certain embodiments, plate thickness can from 0.001 millimeter to 3 millimeters.

Fig. 3 a-j shows a tissue and to dissect multiple views of a specific embodiment of device.The dissect upper surface of device of its tissue has a sensor base and a removable upper cover.

Fig. 3 a is one and comprises a tissue without 301, the handle in tip, 302, handle 303 of protuberance and cracking section and to dissect the perspective view of embodiment of device.In an illustrated embodiment, tip 301 is round and blunt.The tip of shown embodiment also lacks electric current cutting power.Ultrasonic energy window 307 can position in the upper surface of device.In an alternate embodiment, energy window 307 can be omitted in expection.It should be noted that word ' energy window ' is intended to the U.S. Patent number 7,494 as can be spoken of later, 488 li of so-called amendment plane organize windows/districts, and do not need electrosurgical energy in all embodiments.In certain embodiments, its ' energy window ' can comprise other power radiation devices multiple, comprises high frequency, intense pulsed light, laser, heat, microwave and ultrasound.So-called " energy window " does not necessarily represent the region that energy can be supplied to window equably.On the contrary, the application of some energy window can comprise a series of energy delivery element or other regions.In these energy delivery elements or region, energy will provide with dispersion zone form, a small amount of or do not have energy to be provided in these regions.A ultrasonic energy window configuration may be useful in some application.Application is also allowed the damage of amendment and/or destination organization and/or heating for treatment to increase by the biology of sensing/molecule and/or chemical substance and/or (may in higher energy rank) according to piezoelectric part and/or in order to reduce the energy (in order to increase the content of target chemical substances and/or biological compound as far as possible) to tissue injury.

In certain embodiments, second energy window can also be had, and a microwave launcher or another energy emitting device can be comprised.In some contemplated embodiments, one or more energy window can be positioned on above most advanced and sophisticated and/or handle as other places of this paper are spoken of.Energy window 307 can at least substantitally planar, or can have other shape of cross sections, as long as shape is similar to a part for handle, and such as arc, stepped or other geometry/bending.

Ultrasonic energy window 307 can be configured to such as, irritation cell release chemicals and/or biological label and/or heat target tissue and/or fluid.In an illustrated embodiment, ultrasonic energy window 307 comprises a piezoelectric ceramics.In one embodiment, affiliated piezoelectric ceramics size can be 20 millimeters of x20 millimeter x3 millimeters.In certain embodiments, described piezoelectric ceramics diameter can reach 50 millimeters.In an alternate embodiment, ultrasonic energy window 307 can be omitted in expection.In certain embodiments, described piezoelectric ceramics is made by lead titanate piezoelectric ceramics that (this material can be referred to as PZT8 or PZT4, be manufactured in Micromechatronics, state university, Philadelphia), described piezoelectric ceramics can comprise quartz and/or Barium metatitanate. and/or the membrane polymer Kynoar any size of described ultrasonic energy window size between 1 millimeter to 50 millimeters in certain embodiments in certain embodiments.Some embodiment can comprise multiple ultrasonic energy window.According to the formation of a piezoelectricity and/or surrounding and/or the structure being provided with piezoelectricity, a mounted piezoelectric ceramics can have one or more harmonic frequency.

When surgeon arrives at target area, constraint dissects that the movement of device in region agree can be favourable, but guarantee that surgeon can affect destination organization and/or cell so that analyze simultaneously.But, not cause so around and/or the cell of Geng Shen histologic lesion and/or organization ultrasonic wave action can be dependent on the humidity effect of target area and the moisture content of destination organization and/or the characteristic of its hetero-organization.

In certain embodiments, target cell frequency ranges to a certain extent and energy range is contributed to affecting at 25 to 40 KHz and 3-10 watt and/or 10-30 volt.In certain embodiments, according to tissue and/or the difference of environment, service time may cracking target cell within 5-60 second.Increase ultrasonic energy window 307 and contacting of organizing, such as may press device of dissecting, the intervention tissue fluid between ultrasonic energy window and destination organization and/or water can be reduced, cause increasing the coupling between energy bracelet ditch and destination organization.Such hole increases ultrasonic energy efficiency of transmission.

In certain embodiments, as above speak of like that, use the low-yield party of super rich energy window stimulate tissue after or as an alternative, ultrasonic energy window 307 can such as be better than 40 KHz by higher frequency range to be come for heating and/or treatment and/or infringement destination organization.In some applications, by applying higher energy, scope is as 10-20 watt and/or 30-50 volt, and window 307 may be used for heating and/or treatment and/or damages destination organization.

For embodiment disclosed herein, such as ultrasonic energy window 307 and/or 308, the gap that the ultrasonic technology example come in handy comprises miniaturization melt with the supersonic array of imaging (Makin, Mast, Faidi etc.; UltrasoundMedBiol2005; : 1539-5031 (11) .) and/or for the PRELIMINARY RESULTS of the thermoset ultrasonic applicator in gap and design (Lafon, Chapelon, Prat etc.; UltrasoundMedBiol1998; 24 (1): 113-22.) and/or optimize be used for interstitial heating ablation ultrasonic transducer shape (Lafon, Theillere, etc.; MedPhys.2004Oct.312002; 29 (3): 290-7.) and/or by applying bifrequency simultaneously, the permeable (people such as Schoelhammer, Polat, Mendenhall, Langer of fast skin of high strength supersonic; JournalofControlledRelease, 2012,163 (2): 154-160.) and/or by inter space device (Lafon, Melodelima, Salomir, the Chaelon of high strength supersonic for Micro trauma heating ablation; Int μ Hyperther2007; 23 (2): 153-63.) and/or Theory comparison two space ultrasonic applicator be designed to impel cylindrical region ablation of tissue (Lafon, Chavrier, Prat etc.; MedBiolEngComput1999; 37 (3): 298-303.) feasibility (Chopra, Bronskill, the Foster of the linear array and/or for interstitial ultrasonic heat therapy; MedPhys.2004Oct.312000; 27 (6): 1281-6. interstitials are hyperacoustic) and/or develop the chromic fibrous ultrasonic applicator being used for endoscopic surgery: Animal Experimentation (Lafon, Theillere, Prat etc.; Ultrasonic MedBiol2000; 26 (4): 669-75.) and/or for dynamic angle control thermal therapeutical the chromic fibrous ultrasonic applicator of many parts (Kinsey, Diederich, Tyreus etc.; MedPhys.2004Oct.312006; 33 (5): 1352-63.) and/or evaluate the multielement conduit cooling interstitial ultrasonic applicator (Nau, Diederich, the Burdette that are used for high-temperature hot therapy; MedPhys.2004Oct.312001; 28 (7): 1525-34.) and/or the feasibility (Jarosz of the gap applicator of the waveguide of ultrasound thermal therapy; IEEETransBiomedEng1996; : 1106-1543 (11) .) and/or the transurethral ultrasonic array of prostate thermal therapeutical: preliminary research ((Diederich, Burdette; IEEETransUltrasonFerroelectrFreqControl1996; 43 (6): 1011-22.), these patents are incorporated herein by reference all in full.

In certain embodiments, a ultrasonic energy window can be had to be mixed with and to allow optionally to regulate one or more parameter, comprise power, voltage and/or frequency, as mentioned above.This have for, such as, surgeon is allowed to use higher energy/power contact the tissue/organ expected, if a surperficial and/or fibrous tissue around it of the tissue modification rod and organ that are comprised ultrasonic energy window by friction is so that by the adjacent surrounding annulus tissue of organ.Then surgeon can turn down power/energy so that limited degree destroys intraorganic cell so that with sample/analyze intraorganic tissue and/or fluid.Or some embodiments may be configured with two independent ultrasonic energy windows. such window can be configured to and provides relatively high power/energy, and as mentioned above, another such window can be configured to provide relatively low power/energy.

In certain embodiments, ultrasonic energy window can in order to perform the operation moderate stimulation and/disturb bad biomembrane.Because form biomembranous microorganism generally to have and the antibacterial of free-floating or the significantly obstructed characteristic of other microorganism, described interference can form biomembranous microorganism by for allowing sampling and/or analyzing.Such sampling/analysis may not have to be difficult under described stimulation/interference or cannot to complete.

Can have for embodiments more disclosed herein, such as, example for the ultrasonic technique of ultrasonic energy window 307 and 308 can be, by applying the fast skin infiltration of double frequency simultaneously, high strength supersonic (Schoelhammer, Polat, Mendenhall, Langer, etal; JournalofControlledRelease, 2012,163 (2): 154-160.) and in the glucose measurement body of ultrasonic mediation this big cymbals array (Lee, Nayak, Doddsetal is used; UltrasoundMedBiol.2005.31:971-977) and low frequency ultrasound on the mannitol of the impact of transdermal penetration: in body and vitro skin comparative study. (Tang, Bankschtein, Langer:J.Pharm, 200291:1776-1794) and uses iontophoresis to pass through the saturating skin drug-supplying system (Yang of fluorinated steroids An Naide gel, Kim, Yun; Arch, PharmRes.2006 29:412-417) find, be hereby incorporated by full with it.

Fig. 3 a is the perspective view of a device embodiment of dissecting, and this device of dissecting comprises 301, one, tip handle 302, and a handles 303.Being positioned at, handle is a base 384, and this base can hold seat 388, and sensor 389 can be supported neatly in this seat.In certain embodiments, sensor 389 can comprise a nano-sensor.In certain embodiments, base 384 can recessed handle 302 and/or most advanced and sophisticated 301.In certain embodiments, base 384 can be outstanding from handle 302 and/or most advanced and sophisticated 301.In certain embodiments, base 384 can flush in handle 302 and/or most advanced and sophisticated 301.In certain embodiments, sensor 389 can comprise a silicon nanowire sensor.In certain embodiments, sensor 389 can comprise a biological nano sensor.In certain embodiments, nano-sensor 389 can comprise a conductor aggregation and/or glass and/or aggregation and/or plastics and/or Graphene and/or carbon etc.In certain embodiments, can there be fixed seat at seat 388.In certain embodiments, seat 388 is removable.In certain embodiments, sensor 384 can be fixed in seat 388.In certain embodiments, sensor 389 can be separated from seat 388.Expection in an alternate embodiment, can omit seat 388.

In certain embodiments, base can comprise lid mobile device and/or a covering tip.Upper cover most advanced and sophisticated 381 and the method 383 for optionally moving a lid can be positioned at proximate base 384..The example of planting lid mobile device can comprise track, groove, track, ratchet, cable, arm, line etc.In the embodiment shown, lid mobile device comprises track.A part for described handle can comprise lid mobile device 383 in certain embodiments.Expection in an alternate embodiment, can omit lid mobile device 383.Base 384 can comprise one or more base wall 385.Base wall 385 can comprise the fluid transfer port 386 for fluid-transporting tubing.Base wall 385 can comprise the fluid extraction port 387 of fluid extraction conduit.Fluid transfer port 386, in certain embodiments, can be configured to carry gas, such as low humidity gas, rare gas and/or other gas become dry for making base 384, particularly after base 384 is cleaned.In such embodiments, fluid extraction port 387 can be used for the gas removing base 384, to allow in the Utopian circulation base 384 of these gases. and in certain embodiments, base wall 185 can comprise one or more port 386 and/or 387.In figure 3 c, lid 380 can move along lid mobile device 383, and can be opened or closed by inner control line. in certain embodiments, cover by motor removing.The rear end of lid 182 can be fixed to lid 380.In certain embodiments, cover 382 rear end be not be fixed to lid and himself be the another part being connected to device of dissecting.In certain embodiments, base 384 and/or base wall 385 can hold temperature-adjusting device 395, and this device is for revising the temperature in base 384 and lid 380.Temperature adjustmemt device 395 can comprise, such as heater, peltier effect cooler, heat pump etc.Temperature change device 395 can be used for heating the liquid through port 386.Temperature-adjusting device 395 is alternately for bodily tissue and/or the fluid of device acquisition of dissecting described in heat tissue and/or other use.In certain embodiments, temperature-adjusting device 395 can promote and/or suppress the change of some chemical reaction and/or combination according to demand, to use sensor 389 to detect some biomaterial. in certain embodiments, base 384 and/or base wall 385 can hold hybrid element 396.Temperature-adjusting device 395 can comprise a resistance heater in certain embodiments.In contemplated embodiments, heater 395 can comprise one and draws together thin film resistor and/or piezoelectricity heater and/or have the miscellaneous equipment heating fluid capacity.In certain embodiments, hybrid element 396 can comprise a propeller by an electro-motor running.In certain embodiments, hybrid element 396 can comprise one or more wing flap compared with inert polymerization plastics, and this wing flap is positioned at a pillar operated by electro-motor.

Other Available Materials of wing flap can comprise polymer, metal, pottery etc.In another embodiment, hybrid element 396 can comprise one by vibration magnet rotors independent stirring rod.In the embodiment of an expection, one group of independent port initial sum can end at base 384, and can pass through a tubes connection.This tubes connection is in a piezoelectric pump and/or other fluid motor and/or other fluid drive apparatus.In the embodiment comprising one or more this kind of additional ports, these one or more ports can be arranged on the opposing end portions of base 384, can be applied to whole base 384 more equably when one or more fluids are carried and/or when applying vacuum.In an alternate embodiment, temperature-adjusting device 395 and/or hybrid element 396 can be omitted in expection.One or more sensor 378 and/or 379 can be positioned at base 384 li.In certain embodiments, one or more sensor 378 and/or 379 can be positioned at base wall 385 and/or lid 380.Sensor 378 and/or 379 can comprise the object lesson of any discussed sensor relevant to sensor 310 and/or 314.Sensor 378 and/or 379 can report that the base area 384 li of nano-sensor 389 and/or the situation of surrounding and/or situation change.

The method that nano-sensor can be had by its ordinary skill person and manufacture/obtain, the method includes but not limited to: United States Patent (USP) 5,8,022,444B2 title " biosensor and its method manufactured " and/or United States Patent (USP) 8,314,357B2 title " nanowire biosensor of Joule heating " and/or United States Patent (USP) 6,8,236,595B2 title " nanowire sensor; nano-wire array and its making side " and/or " using a silicon nanowire array label dissociative DNA " (kulkarni, the people such as Xu, Ahn, Amin; JBiotechnol, August 31 in 2012; 160 (3-4): 91-6) and/or " conducting polymer: the frontier of biosensor " (people such as Borole, DD; DesMonomersPolymers, 20069 (1): the 1-11 pages) and/or " conducting polymer of DNA sensor and DNA card: from being fabricated into Molecular Detection " (Mailley, Livache; Nucleic acid and protein electricity ization – are in order to realize the electrochemical sensor for chromosome and protein, 2005: the 297-330 pages) and/or " in order to electrochemical DNA detect conducting polymer " (Peng, H. etc., biological substance, 2009,30 (11): the 2132-2148 pages) and/or " electroactive polymer: Intelligent Material Systems " (Wallace, Spinks, Teasdale, 317th volume, (Wanekaya, waits people to biosensor 1998.287-290) based on conductive polymer nanometer line; The handbook of biosensor and biochip, 2007 (2) 831-842 pages) and/or " conduction electroactive polymer: Intelligent Material Systems ", the second edition, 2002 (Wallace, Spinks, Kane-Maguire the 224th page).And/or for DNA detection novel conductive polymer (Peng etc., Macromolecules, 2007,40 (4): the 909-914 pages) and/or " use the sequence variations of nano wire nano-sensor and direct hypersensitization ground electro-detection DNA and DNA " (NanoLetters2,2003,4 (1): 51-54 pages .) and/or " based on silicon nanometer sequence specificity without mark DNA sensor " (Li, etc., NanoLetters2,2004.4 (2): the 245-247 pages .) and/or " use silicon nanowires to detect: charge layer Range-dependent " (the people such as Zhang, nanometer bulletin, 2008.8 (4): the 1066-1070 pages) and/or for High sensitivity and optionally detect biological and chemical material nano wire millimicro sensor (people such as YiCui., Science. the 293rd volume (2001) the 1289th page) and/or United States Patent (USP) 17, 993, No. 538B2, " composition is stimulated by energy and locally removes the condensed gas layer of solid title, solid-state chemical reaction with this layer is produced " and/or United States Patent (USP) 7, 674, No. 389B2, title " the exact form amendment of low energy electrons Shu Jinhang nanodevice " and/or U.S. Patent number 5, 645, 740, title " manufactures system and the combination of microtexture substrate and implant " and/or United States Patent (USP) 5, 607, 607, title " manufactures system and the combination of microtexture substrate and implant " and/or United States Patent (USP) 7, 416, 911B2 title " molecular structure is connected with biomolecular structure and the micro structure of quasiconductor and nanostructured by electrochemical method " and/or United States Patent (USP) 7, 294, 526B2 title, " by the nanocomposite optical sensor of molecule from combination " and/or U.S. Patent number 6, 870, 235B2, title " has silicon-on-insulator biosensor apparatus " and/or U.S. Patent application 12/065, No. 857, publication number: US2009/0140167A1, title " the nano tube based sensing system in fabric and manufacture method " and/or United States Patent (USP) 6, 716, No. 620, March 26 calendar year 2001 submits to, be entitled as " biosensor and correlation technique " and/or United States Patent (USP) 7, 129, No. 554B2, be entitled as " nano-sensor " and/or U.S. Patent application 13/209, No. 442, publication number is US2012/0304776A1, be entitled as " chemistry and biomedical nano-sensor ".In this as reference, its entirety is quoted above.

Such as, some reagent and/or chemicals and/or biochemistry thing can exist and/or carry to and/or from base area remove promotes sensor to use and/clear up.These reagent and/or chemicals and/or biochemistry thing can include but not limited to alcoholic solution, mercaptan, SDS (sodium lauryl sulphate), water, argon, sodium chloride, sodium bicarbonate buffer agent, EGTA (ethylene glycol tetraacetic), EDTA (ethylenediaminetetraacetic acid), sulfo group-NHSdiazirine (sulfo group SDA), PBS (phosphate buffered saline (PBS)), and/or in tween 20 (PBST), etc.Such reagent and/or chemical substance and/or biochemistry and their acquisition and use be those of ordinary skill in the art can technology, include but not limited to: United States Patent (USP) 6,593, No. 093B1, title " detection of A group B streptococcus "; U.S. Patent application publication number 2012/0228155A1 title " analyzes the electromagnetic detection of thing "; U.S. Patent application publication number 2009/0186774A1 title " microarray that septicemia detects "; European patent 2526427A2, is entitled as " quick pathogen diagnosis apparatus and method "; U.S. Patent application publication number 2006/0223080A1, title is that " method detecting A group B streptococcus " utilizes nanoparticle probes to detect scan-side face DNA array (TATON, MIRKINLESTINGER; Science, JIUYUE in 2000 the 289th volume on the 8th, No. 5485,1757-1760 page .); Nanometer light biosensor is utilized to detect MRSA (STROHSAHL, MILLER, KRAUSS; Proc, SPIE, 7167OS roll up, 1-12 page).; Utilize the multiplexing detection of super responsive selectivity (CIU, king, the HUYNHLIEBER of the cancer markers of nano wire nano-sensor; Harvard University, 1-21 page .); For field effect transistor sensing device (MOHANTY, CHEN, king, HONG, ROSENBERG, the WEAVERERRAMILLI of breast cancer diagnosis; Boston University, 1-25 page); In this as reference, its entirety is quoted above.

In certain embodiments, sensor 378 and/or sensor 379 can comprise a photographic head.In certain embodiments, sensor 378 and/or sensor 379 can comprise an optical fiber for and/or optical fiber be photographic head and/or CCD photographic head and or other photographic head.

In certain embodiments, one or more electromagnetism delivery element 377 can the tip of position and/or upper cover 380 and/or upper cover 381 most advanced and sophisticated in base 384.Other embodiments can comprise one or more electromagnetism delivery element.Its element at any suitable seat on device of dissecting, can include but not limited to sensor 389 or seat 388..Useful electromagnetism delivery element can include but not limited to: LED, laser instrument, fiber optics, filament, photoelectric material, RF transmitter etc.The transmitting of electromagnetism can be absorbed by the emission spectra of the biomolecule on chemicals and/or sensor and/or base area and/or reverberation and/or chemicals and/or biomolecule in certain embodiments, and/or further product can be detected with sensor 378 and/or sensor 379.

In one embodiment, lid 380 and/or base 384 can be arranged to reflecting electromagnetic radiation.Reflecting electromagnetic radiation and/or there is minute surface character sensor 378 and/or 379 can be allowed for detecting electromagnetic radiation.. in certain embodiments, lid 380 and/or base 384 comprise the film coating of a covering material.In certain embodiments, material can be plastics and/or molded polymeric and/or crystal and/or glass and/or metal etc.In certain embodiments, lid 380 and/or base 384 comprise one deck aluminum.. in certain embodiments, aluminum film comprise a shielded aluminum and/or enhancing aluminum and/or by ultraviolet enhancing aluminum (maker can be EdmundOptics, Barrington, New Jersey, the U.S.).

In the embodiment depicted, cover 380 and can comprise plastics.In other embodiments, cover 380 materials comprised to include but not limited to: polymer, quartz, glass, carbon-based material, silicate and/or metal.

In certain embodiments, one or more sensor such as sensor 310 and 314 can be arranged on device.Sensor 310 and 314 can comprise any sensor described in this manual.In certain embodiments, sensor 310 and/or sensor 314 can comprise photographic head.In certain embodiments, sensor 230 and/or sensor 314 can comprise optical fiber and/or fiber optic camera machine and/or ccd video camera and/or other photographing unit. other embodiment can dissect what has a high regard for suitable seat on comprise one or more sensor, include but not limited on protuberance, on tip, and on handle.The sensor come in handy comprises heat sensor, photoelectricity or optical pickocff, photographing unit etc.In certain embodiments, one or more sensor can be used monitor close to handle distal end or most advanced and sophisticated on the electric current that can exist pass through after electrical impedance or temperature conditions.Some embodiments can also comprise one or more sensor in conjunction with MEMS (MEMS) technology, such as MEMS gyro instrument, accelerometer etc.Such sensor can be placed in many places on device of dissecting, and comprises the seat in handle in certain embodiments.In certain embodiments, sensor 314 can comprise fiber optics element.

In one embodiment, sensor can be configured to the temperature of the adjacent tissue of sensing apparatus.Temperature sensor can be configured to the fluid sensing one or more neighboring devices in addition, such as tissue fluid and/or the fluid introduced by surgeon.

In certain embodiments, one or more electromagnetism conveying element 315 can be positioned on tip or handle.Other embodiment can comprise one or more electromagnetism delivery element on tissue dissects any other suitable seat of device, and this element includes but not limited at jut, or on tip, and on described handle.Useful electromagnetism conveying element comprises: LED, laser instrument, optical fiber, long filament, photoelectric material, RF transmitter etc.

As shown in Figure 3 a, lever 303 can comprise one or more port.Various conduit can pass through this port.If in these embodiments conveniently needed for, multiple conduit can be bundled in together.In addition, a power transfer conduit harness 399 can be provided.Mixed item pipeline harness 299 can comprise other conduits various, such as, for one or more conduit as sensor 310 and 314, for the conduit of one or more electromagnetism delivery element 315, for fluid transfer port 316 ,/the conduit of vacuum ports 317 of and/or bleeding.In addition, miscellaneous conduit harness 399 can comprise one or more additional conduits, such as one or more additive fluid delivery conduit.This conduit can carry a liquid or gas to the port 386 of device base 384 li of dissecting.Miscellaneous conduit harness 399 may further include one or more fluid extraction conduit (port 387 from base 384).This extraction conduit is used for withdrawn fluid (liquid or gas), guides fluid to an independent fluid/chemicals sensor.

This fluid delivery catheter (being directed to port 386) can be configured to conveying, such as, and buffer agent, cleaning agent, quencher, reagent, biologic artifact, inert compound, gas.The fluid being flowed to port 386 by delivery conduit can be increased energy, such as, heat, and ultrasonic energy supply can comprise detergent, antibody, medicine etc.

Fluid extraction conduit (from port 387) not only can be used for extracting the unwanted fluid of health, can also be used for removing the fluid being incorporated into port 386 by fluid delivery catheter a wash circuit.This fluid is used for originally, and such as, wash and/or sterilize some biological tissues and/or tissue are dissected the parts of device.Fluid extraction conduit (from port 387) can also carry out withdrawn fluid in order to external analysis.Some embodiment can be configured to provide bubble so that user distinguishes the various fluids that the fluid extraction conduit from port 387 takes out to many group different fluid.

In certain embodiments, shaking device 370 can be arranged in handle.Other embodiment can comprise one or more shaking device at any suitable seat on device of dissecting, and its seat includes but not limited on jut or tip, and on described handle.Suitable shaking device can comprise piezoelectric, ultrasonic motor and stator, piezo-activator, and vibrations motor, such as, be arranged on the eccentric weight on gear.It is ultrasonic that some shaking device can be configured to launch in 20-40 kilohertz range.Other shaking devices can comprise the electromagnet actuators of operating frequency range in 150-400 hertz.In certain embodiments, one or more shaking device may be used for providing additional power, to dissect passing through of device with convenient tissue.In certain embodiments, one or more shaking device can be used for reducing on electrosurgery parts or other impurity of dissecting on device parts.In another embodiment, shaking device directly or indirectly can be connected to one or more described cracking section.Some shaking device can help to reduce and/or remove foreign material.In certain embodiments, shaking device can or be used in operation, help the movement of device between tissue of dissecting in addition.In the described embodiment, expect that low-frequency shaking device can contribute to described movement especially.In addition, also can to help described movement in the handle close to device of dissecting shaking device position.On the contrary, shaking device is positioned at the accumulation that can be particularly useful in the most advanced and sophisticated upper impurity of prevention close to most advanced and sophisticated and/or the higher vibration frequency device of use.

Fig. 3 d, c illustrate that tissue is dissected device and be moved and reveal the upper cover 380 showing base.

Fig. 3 f, e illustrate that tissue device of dissecting is distally mobile to cut out and/or sealed base with lid 380.

The viewgraph of cross-section of Fig. 3 g upper cover 380 embodiment, comprises the groove 391 described in and a protuberance 392.Groove 392 can be used to guide fluid in upper cover 380, so that fluid-mixing and/or guiding fluid take the seat in base or in upper cover to needs cleaning side and/or guiding fluid to sensor seat and/or the fluid in certain temperature range.As described in similar, protuberance 392 also can be used to guide fluid to one or more described seat and/or in order to a concrete use stirred fluid.

Fig. 3 h is the viewgraph of cross-section of base 384 embodiment, comprises the groove 393 described in and a protuberance 394.Groove 393 can be used to guide fluid in base 384, so that fluid-mixing and/or guiding fluid take the seat in base or in upper cover to needs cleaning side and/or guiding fluid to sensor seat and/or the fluid in certain temperature range.As described in similar, protuberance 394 also can be used to guide fluid to one or more described seat and/or in order to a concrete use stirred fluid.In certain embodiments, upper cover 380 and base 384 can create a common space when upper cover 380 belongs to closed condition.In certain embodiments, upper cover protuberance 391 can with base groove 393 or base extension 394 joint effect fluid to a kind of desirable state.

In Fig. 3 g and/or 3h, in base 384 and/or upper cover 380 show in inner face, such as to arrange one or more groove 391 and 393, to be conveyed through port 386 fluid to one or more desirable seat.In certain embodiments, groove can be configured to promote fluid chemical field and/or guide fluid to needing clean region and/or sensor region.In base 384 and/or upper cover 380 show in inner face, such as to arrange one or more groove 392 and 394, to be conveyed through port 386 fluid to one or more desirable seat.In certain embodiments, groove can be configured to promote fluid chemical field and/or guide fluid to needing clean region and/or sensor region.In certain embodiments, most protuberance can form a groove, in other embodiments one or more groove can upper cover and or base surface formed.

Figure .3e institute show and closes upper cover 380, and the space promotion formed in the upper cover 380 that fluid can be closed again is cleaned.Close upper cover 380 and can also promote isolation biological tissue and/or fluid.Such as, close upper cover 380 can allow to analyze tissue and/or fluid when not infected by other biological tissue and fluid.Cleaning to use the angle of different seat and/or sensor and/or various angle to carry out further.In Fig. 3 i the configuration that shows can mainly in order to catch tissue for analyzing and/or fluid, but some embodiment can be configured to seat 388 and tend to organize the rear end of device of dissecting, and makes this seat towards (tending to) fluid port 386 to promote the cleaning of sensor 389.

In order to the fluid delivery ports 386 of fluid conveying with can also be used to conveying in order to the fluid extraction port 387 of fluid extraction and/or remove fluid, such as, include but not limited to, reagent and/or analyze thing and/or eluent and/or eluate.In certain embodiments, from fluid delivery ports 386 fluid conveying and or from fluid extraction port 387 fluid extraction can with a pump and/or other tubes connection (this tubes connection is connected and the conduit of fluid delivery ports 386 and fluid extraction port 387 in one or two) in a circuit.This circuit is used for recirculation and/or heating and/or insulation and/or mixing and/or add the material that reagent and/or removing reagent and/or other comes from upper cover 380 and/or base 384.In certain embodiments, to dissect outside device at tissue and to connect and the pump of circuit of conduit between port 387 and port 386 can be used for mobile fluid.The fluid space that upper cover 380 and base 384 (having spacial element) provide can with to enter and/or Fluid Volume for port 386 and/or 387 conduit is estimated.Described estimator can compare with the amount that computer-aided design calculates.

The side-looking of the embodiment that figure .3i presents before being inside figure .2a, shows location, a seat and/or seat projected state (comprising a nano-sensor) makes this seat can allow have with the tissue of some processes or fluid the example contacted.Described tissue device of dissecting can comprise an executor 390.Executor 390 can comprise a motor in certain embodiments.In certain embodiments, executor 390 can comprise one or more described motor, such as screw drive motor, gear motor, hydraulic motor etc.In certain embodiments, executor 390 can comprise gear-box, motor control circuit, monitor, remote control equipment etc.In certain embodiments, executor 390 can be controlled by steel wire and/or spring or move.In certain embodiments, executor 390 can be manually controlled or move.In certain embodiments, executor 390 can be omitted.In certain embodiments, seat 388 can be configured to manually promote or tilt.In certain embodiments, seat 388 can be configured to and have the arrangement of the different angles of several fixed number between handle 302 and/or base.In other embodiment, seat 388 can be configured to and have the arrangement of numerous different angles between handle 302 and/or base.

For carry the device 397 of ultrasonic energy can be positioned at the base wall 385 li of base 384 li/.Vltrasonic device 397 can be configured to, such as, and hot fluid: contribute to clean one or more parts of device of dissecting of organizing and comprise such as base 384: the mixing helping reagent and/or organic chemicals and/or biomolecule; Biomolecule and/or other material and acceptor and/or sensor is helped to fix; Help to remove biomolecule and/or other materials from acceptor.In the embodiments described, ultrasonic unit comprises piezoelectric ceramics.This piezoelectric ceramics can be measured and be approximately 2 millimeters * 2 millimeters * 4 millimeters in certain embodiments.In an alternate embodiment, ultrasonic unit 397 can be omitted in expection.In certain embodiments, piezoelectric ceramics is made by lead titanate piezoelectric ceramics that (this material can be referred to as PZT8 or PZT4, be manufactured in Micromechatronics (micro machine), state university, Philadelphia) and can be operated by 2-5 watt between 10-20 volt.And/or can be configured to shake between 300-500 KHz.In certain embodiments, piezoelectrics can comprise quartz and/or Barium metatitanate. and/or membrane polymer Kynoar.In certain embodiments, any dimensional measurement of ultrasonic unit is all between 1 millimeter to 20 millimeters.Some embodiment can comprise most ultrasonic unit.In certain embodiments, ultrasonic unit can be configured in two or more phase cross surface, such as scheme a upper surface of a part of ultrasonic unit 397 position and handle 302 in the embodiment shown in .3b, another part position is in the base wall 385 crossing with handle 302 upper surface.In the embodiment shown, wall 385 in the upper surface of handle 302 with the substantially angle of intersection of 90 degree.

Figure.In the embodiment that 3i limits, sensor 389 can be made to increase and/or change contact and/or friction in one or more angle at seat 388 and/or sensor 389 position when upper cover is in open mode, the tissue of promotion sensor 389 and process and/or fluid have a desirable reaction.

In the embodiment of figure shown in .3j, can ideally or at least suitable applying for some at least substantially parallel with handle 302 angle seat 388 and/or sensor 389 position.

In certain embodiments, one or more suction/vacuum ports 317 can be provided in tip or far-end handle.Port can be connected to a vacuum; Vacuum can comprise a Beng Huoyige negative pressure chamber or a syringe at fluid conduit systems afterbody.Other embodiments can comprise one or more suction/vacuum ports.Its seat can organize any other place be applicable to of device of dissecting again, comprises and being singly not limited to: on protuberance or on tip and on handle.In certain embodiments, a fluid delivery ports 316 can be provided.In certain embodiments, fluid delivery ports can connect and pump or high-pressure fluid.In certain embodiments, port for good and all can be opened when making primer pump or high-pressure liquid system fluid and can be transferred through its opening.In other embodiments, port can be closed and optionally open to make conveyance fluid.Other embodiments can comprise one or more fluid port.Any other place be applicable to of device of dissecting can organized in its seat, comprises and being singly not limited to: on protuberance or on tip and on handle.Useful fluid port can be dissected device at tissue, and polymer line, flexible pipe etc. comprise passage.The fluid deriving from outlet can comprise ionic liquid, such as salt, medicine (including but not limited to antibiotic, anesthetis, antitumor drug, antibacterial etc.), not ionic liquids, with or gas (including but not limited to nitrogen, argon, air etc.), in certain embodiments, fluid can under high pressure or injected.Although what be worth proposition is that these elements (316 and 317) are not shown in other all figure, any embodiment as herein described can comprise one or more described element.

In the embodiment shown, 318 represent an antenna, and such as one is configured to transmission information to the RFID label tag of a receptor or Bluetooth antenna.Comprise in the embodiment of a RFID label tag at antenna 318, described RFID label tag can comprise a RFID transponder.Described RFID label tag can comprise a passive label in other embodiments.Although it should be noted that antenna 318 is not shown in other all figure, any embodiment as herein described can comprise one or more described element.Other embodiments can comprise one or more antenna on any applicable seat of tissue dissector, and its seat includes but not limited on protuberance, or on most advanced and sophisticated and handle.Comprise in the embodiment of a RFID transponder at antenna 318, this transponder can comprise a microwafer, and such as one can rewrite the microwafer of storage.In certain embodiments, described mark size can approximately be less than several millimeter.In certain embodiments, a card reader can create an ac magnetic field, and this magnetic field can start described antenna, such as a RFID transponder, and can send data by frequency modulation.In the embodiment comprising one or more RFID label tag (or other everyday), the seat of RFID label tag or other antennas can by a high-frequency alternating current Magnetic oriented.Can draw with the 3D of object and contact in described seat.In one embodiment, this card reader can produce an ac magnetic field.In the described embodiment, alternating electromagnetic field can be shortwave (13.56 megahertz) or ultrashort wave (865-869 megahertz) frequency.What come in handy can see No. 2007/0225550, U.S. Patent application relative to the example of the system and method for the operating theater instruments in patient body for mapping/following the trail of, be entitled as " system and method relative to the 3D of operating theater instruments in patient body follows the trail of ", at this, its full content be incorporated herein by reference.

In other embodiments, antenna 318 can comprise a Bluetooth antenna.In the described embodiment, the signal intensity of perception from Bluetooth antenna 318 can be configured at the multiple corresponding bluetooth receiver of known location, and these data of triangulation in case by the signal framing from Bluetooth antenna 318 thus the tissue be positioned in patient body is dissected device.Other embodiments can be configured to use based on angle, electronic location Technology and equipment, to be positioned at antenna 318.Some embodiment can comprise use beam antenna, and it can be used for the precision increasing location.Other embodiments can comprise and use other to have hardware for locating and/or signal, such as wireless and cellular signals.

Most advanced and sophisticated 301 can be connected with a robot arm in certain embodiments.In certain embodiments, most advanced and sophisticated 301 can be connected with a robot arm with a part for handle 302.In certain embodiments most advanced and sophisticated 301 and/or a part for handle 302 and/or a part for lever 303 can be connected with a robot arm.In certain embodiments, robot arm can comprise one or more motor, such as screw drive motor, gear motor, hydraulic motor etc.In certain embodiments, robot arm system can comprise gear on worm, video camera, circuit for controlling motor, monitoring, remote control equipment, light source, touch screen etc.

Fig. 3 k and 3L demonstrates tissue and to dissect the alternative embodiment of device, and wherein that upper cover 380 comprises one or more opening (380L of 380k and Fig. 3 L of Fig. 3 k).The embodiment that the element that all the other Fig. 2 K with 2L show can demonstrate with Fig. 3 a-3j is similar or identical.

As shown in figure 3k, at least one opening 380K is present in upper cover 380.In certain embodiments, upper cover 380 can be configured at least fully to cover (except opening 380K) space and make the vacuum applied by port 387 that 380K can be allowed to have suction.In shown embodiment, opening 380K can be circular.In shown embodiment, opening 380K diameter can be approximately 1.5 millimeters.In other embodiments, the diameter range of opening 380k can be from about 100 microns to about 100 millimeters.In the embodiment of other expection, opening 380k can have various geometry, includes but not limited to square, rectangle and/or polygon.In the described embodiment, sensor 389k can comprise nano-sensor.In certain embodiments, lid 80 can be configured in the inner space at least generally sealed, thus the vacuum that port 387 is applied can cause opening 380K to have suction.In the embodiments described, seat 388 can lifting and or decline, with allow sensor 389k close to and/or away from opening 380k so as to increase and/or reduce with pass through to be inhaled into after port 387 applies vacuum in upper cover 380 with the contacting of the tissue in base 384 and/or fluid.Do not show at this view the executor still spoken of in disclosure book other places and can be configured to energy sliding seats 388 and/or sensor 389K.When the fluid after applying suction by port 387, outside upper cover 380 and/or tissue can be forced/pull to the EDGE CONTACT with opening 380K, these materials can be sucked into opening 380K when organizing device of dissecting have motion or do not move further.Can to contact with sensor 389 and analyzed at dissect fluid beyond device and/or tissue of tissue before.Do not show at this view the element in base and upper cover still spoken of in disclosure book other places can be configured to move, stir and/or change the temperature of the fluid in base and upper cover to contribute to cultivating and/or analyzing and/or analyze again and/or clean and/or safeguard.The fluid entering upper cover 380 can be included but not limited to by several factors drive and restriction: openings of sizes, outside environment, organizational environment, and/or from the normal pressure of the fluid of fluid delivery ports 386 and/or the vacuum from fluid extraction port 387.

The handle of Fig. 3 K comprises antenna 318K further.In the embodiments described, 318K represents an antenna being configured to signal to receiver.In certain embodiments, antenna 318 can comprise any antenna package in this book described by other places containing such as, at this any antenna relevant to antenna 318.Comprise in the embodiment of a RFID label tag at antenna 318, RFID performance can comprise a RFID transponder.

As shown in figure 3l, at least one opening 380L is present in upper cover 380.In the embodiments described, opening 380L can be circular.In the embodiments described, opening 380L approximately has the diameter of 1.5 millimeters.In the embodiment described by Fig. 3 L, the allowing at least partially of sensor 389L can be given prominence to tissue and to be dissected the part of device, enters the space beyond device of dissecting to carry out biological tissue and/or liquid perception and/or to take sample and/or side-looking.In other fact Examples, opening 380L diameter can approximately from 100 microns to 100 millimeters.

Various geometry can be had at the embodiment split shed 380L of other expection, include but not limited to square, rectangle and/or polygon.Such as, the opening of rectangle can allow to be pinioned sensor by band and passes through opening.The sensor 389L helped by band can by opening 380L, as shown in figure 3l.The band arrived from the side can similarly be a line.In certain embodiments, the material of sensor and/or described band is flexible.Pliability contributes to the integrity when sensor enters outside environment by opening (above cover and/or organize and dissect on device).In this process tissue dissect device can when having or carry out without when affecting.In the embodiments described, sensor 389L is a nano-sensor.In certain embodiments, upper cover 380 can be configured at least roughly close out after an inner space makes port 387 apply vacuum and opening 380L can be allowed to have suction.In Fig. 3 L, at least a part for sensor can be given prominence to tissue and to be dissected the opening 380L of device, allows its part contact dissect tissue outside device and/or fluid.In the embodiments described, seat 388 can lifting and or declining, to allow sensor 389L by opening 380L to return tissue outside upper cover and/or base and/or tissue dissect device of the inside of the adjacent upper cover of base and/or contact and/or fluid.Do not show at this view the executor still spoken of in disclosure book other places and can be configured to energy sliding seats 388 and/or sensor 389L.The fluid entering upper cover 380 can be included but not limited to by several factors drive and restriction: openings of sizes, outside environment, organizational environment, and/or from the normal pressure of the fluid of fluid delivery ports 386 and/or the vacuum from fluid extraction port 387.Sensor 389L can receive and/or send one or more signal from/to a datatron backwash.Sensor 389L can by transfer in the outside of upper cover and/or inside upper cover in this process.Can be cleaned when sensor 389L is retracted in upper cover, as herein other local are spoken of.

Sensor 389L can be connected with an antenna, its antenna can receive when sensor 389L transfers outside upper cover 380 and/or send one or more from/to the signal of datatron.Or in addition, can local store by the data of sensor 389L analysis tissue and/or fluid and send later.Such as, the data obtained after analysis can send with signal after 389L is retracted in upper cover 380 again.Alternatively, described signal can send after surgery.Under such method, signal need not use wireless transmission.Some embodiment can be configured to local to store, a bin afterwards, such as USB can from tissue dissect device take out then by its information stored in computer to analyze.

Sensor 389L is retracted can be cleaned after upper cover 380, as herein speak of.In other embodiments, sensor 389L at least partially can position in a flexible roll and/or can be disposable.Such as, some embodiment can comprise one or more flexible nano-sensor 389L.Its sensing station in a flexible roll or the stacking upper part making roll or a stacking part can give prominence to upper cover 380, such as, passes through 380L, to analyze.

When tissue, after fluid analysis completes, some embodiment can be configured to can rolling roll, reverses stacking, and/or abandons part that sensor 389L is previously used and/or dew shows new a part of sensor 389L to analyze further.Or the used part of sensor 389L can be stored in tissue and dissect in device and then throw away after operation terminates.In other embodiments, nano-sensor 389L (being such as placed in the nano-sensor on flexible roll) can be given prominence to a part for device of dissecting when not manually being extended/regaining opening 380L flexibly at least partially.The method that flexible nano-sensor can be had by its ordinary skill person and manufacture/obtain, includes but not limited to: the manufacture (Lee, Kim, the Zheng that are used the nano wire electronic product of non-traditional materials by water auxiliary transmission Method of printing; NanoLett, 2011,11 (8): 3435-9) and " forming vertical transitions silicon nanowire array by cracking " (Weisse, Kim, Lee, Zheng; NanoLett2011,11 (3): 1300-1305), at this, its full content is incorporated herein by reference.

The handle of Fig. 3 L comprises an antenna 318L.In the embodiments described, 318L represents the antenna that is configured to send signal to receiver.In certain embodiments, antenna 318L can comprise any antenna spoken of herein, comprises any antenna related with antenna 318L.Comprise in the embodiment of a RFID label tag at antenna 318L, described RFID label tag can comprise a RFID transponder.

The upper surface of device can have an energy window 307. in certain embodiments, and energy window 307 comprises the window of an electrosurgical energy.In an alternate embodiment, energy window 307 can be omitted in expection.It should be noted that word ' energy window ' is intended to the U.S. Patent number 7,494 as can be spoken of later, 488 li of so-called amendment plane organize windows/districts, and do not need electrosurgical energy in all embodiments.In certain embodiments, its ' energy window ' can comprise other power radiation devices multiple, comprises high frequency, intense pulsed light, laser, heat, microwave and ultrasound.So-called " energy window " does not necessarily represent the region that energy can be supplied to window equably.On the contrary, the application of some energy window can comprise a series of end or other regions.In these ends or region, energy will provide with dispersion zone form, a small amount of or do not have energy to be provided in these regions.This is configured with and helps some application: it can allow the amendment in some particular organization region in dispersion zone.These region inner tissues can without any amendment, or the degree of amendment is few.Due to the reset mode of some tissue, this configuration may apply some advantage for some.In certain embodiments, second energy window can also be had, and radio frequency electrosurgical energy emitting device or other multiple kinds of energy discharger can be comprised.

In certain embodiments, one or more such sensor such as sensing 310 and 314 can position on device.This sensor 310 and 314 can comprise any sensor that description is described at this.Other embodiments can comprise one or more sensor at other any applicable seats of device of dissecting, and described seat includes but not limited on protuberance, or on tip, or on handle.Useful sensor comprises heat sensor, photoelectricity or optical pickocff, photographing unit etc. in certain embodiments, one or more sensor may be used for monitoring close to handle distal end or most advanced and sophisticated on the electric current that can exist pass through after electrical impedance or temperature conditions.Some embodiment can comprise well one or more sensor comprising MEMS (microcomputer system) technology, such as, and the sensor of MEMS (MEMS) technology, such as MEMS gyro instrument, accelerometer etc.This kind of sensor can many places on device of dissecting, position, comprise in certain embodiments in handle.In certain embodiments, sensor 114 can comprise fiber optic component.In one embodiment, this sensor can be configured to a temperature of the tissue of sensor apparatus periphery.The temperature of one or more fluids that temperature sensor can configure in addition or sensor apparatus is adjacent, the fluid that such as tissue fluid and/or surgeon are introduced.

Second energy window 308 also can comprise in certain embodiments, and can comprise another ultrasonic energy emitter or other multiple kinds of energy discharger.Ultrasonic energy energy window 308 can position in the upper surface of device.In an alternate embodiment, energy window 308 can be omitted in expection.Merit attention, the thing of word ' energy window ' purport electrosurgical energy in all embodiments.In certain embodiments, its ' energy window ' can comprise other power radiation devices multiple, comprises high frequency, intense pulsed light, laser, heat, microwave and ultrasound.So-called " energy window " does not necessarily represent the region that energy can be supplied to window equably.On the contrary, the application of some energy window can comprise a series of energy delivery element or other regions.In these energy delivery elements or region, energy will provide with dispersion zone form, a small amount of or do not have energy to be provided in these regions.A ultrasonic energy window configuration may be useful in some application.Application is also allowed the damage of amendment and/or destination organization and/or heating for treatment to increase by the biology of sensing/molecule and/or chemical substance and/or (may in higher energy rank) according to piezoelectric part and/or in order to reduce the energy (in order to increase the content of target chemical substances and/or biological compound as far as possible) to tissue injury.Energy window 308 can at least substantitally planar, such as, as long as or shape is similar to a part for handle can have other shape of cross sections, arc, stepped or other geometry/bending.

Second energy window 308 also can comprise in certain embodiments, and can comprise another ultrasonic energy emitter or other multiple kinds of energy discharger.Ultrasonic energy energy window 307 can position in the upper surface of device.In an alternate embodiment, energy window 307 can be omitted in expection.Merit attention, word ' energy window ' is intended to the U.S. Patent number 7,494 as can be spoken of later, 488 li of so-called amendment plane organize windows/districts, and does not need electrosurgical energy in all embodiments.In certain embodiments, its ' energy window ' can comprise other power radiation devices multiple, comprises high frequency, intense pulsed light, laser, heat, microwave and ultrasound.So-called " energy window " does not necessarily represent the region that energy can be supplied to window equably.On the contrary, the application of some energy window can comprise a series of energy delivery element or other regions.In these energy delivery elements or region, energy will provide with dispersion zone form, a small amount of or do not have energy to be provided in these regions.A ultrasonic energy window configuration may be useful in some application.Application is also allowed the damage of amendment and/or destination organization and/or heating for treatment to increase by the biology of sensing/molecule and/or chemical substance and/or (may in higher energy rank) according to piezoelectric part and/or in order to reduce the energy (in order to increase the content of target chemical substances and/or biological compound as far as possible) to tissue injury.Energy window 307 can at least substantitally planar, such as, as long as or shape is similar to a part for handle can have other shape of cross sections, arc, stepped or other geometry/bending.

Fig. 3 bb demonstrates a tissue and to dissect the alternative embodiment of device base 384bb.In the embodiment that Fig. 3 bb demonstrates, upper cover can comprise a part of described handle and/or tip.Be described in more detail: base 384bb position is in the hollow opening of handle 302bb and/or most advanced and sophisticated 301bb.In one embodiment, two adjacent parts of handle can be separated by stretch mode or the part that is separated handle and adjacent cusps demonstrates base.

Fig. 4 a demonstrates the embodiment that utilizes the robotic surgical system 400 organizing device of dissecting.System 400 can comprise a tissue and to dissect device 401.Tissue device 401 of dissecting can comprise one, and as spoken of in this paper other places, the tissue comprising most protuberance between one or more recess is dissected device.Organize device 401 of dissecting can be coupled with one or more robotic surgery parts, a such as robotic surgery arm.Most advanced and sophisticated 401a can comprise any tissue and to dissect the embodiment of device/tissue modification rod and/or the tip on its device of dissecting/amendment rod.

In certain embodiments, device 401 of dissecting can comprise a handle, a tip, and/or a lever, as this paper other places are spoken of.In such embodiments, device 401 of dissecting can optionally connect with a robot arm, the device 401 of dissecting being both also can lose with one or more robotic surgery with hand operated and had been coupled, to allow a surgeon long-range and/or indirectly perform the operation with device 401 of dissecting.In other embodiments, tissue dissect device can be configured to overall coupling with or being coupled and one or more robotic surgery parts of non preference in addition.In such embodiments, device 401 of dissecting can be configured to be coupled and a lever and/or handle.In other words, in some fact Example, device 401 of dissecting can only include a tip.

In certain embodiments, robotic surgical system 400 can comprise one or more motor, such as screw drive motor, gear motor, hydraulic motor etc.In certain embodiments, robotic surgical system 400 can comprise gear on worm, video camera, circuit for controlling motor, monitoring, remote control equipment, light source, touch screen etc.Device 400 of dissecting in the embodiment that Fig. 4 a demonstrates comprises a most advanced and sophisticated 401a of device of dissecting, and this tip location is in the end of robot arm.This robot arm comprises most arm paragraph 473, has corresponding joint 476 between its paragraph.Major joint 477 can position in being convenient to support and the place being connected each arm paragraph 473 and less joint 476.Major joint has a main arm segments 474, and this arm paragraph 474 derives from major joint.The action that robot arm is trickleer can have been come by one or more less joint 476.A support 481 also can be provided to support described various robot arm.In some embodiments, support 481 also can be mixed with supports display 479 and/or other display, input, or control assembly, such as a control element 478.In certain embodiments, control element 478 can comprise a Non-follow control switching 478.In other embodiments, control element 478 can comprise a keyboard, mouse, touch screen, virtual reality system, panel, and so on.Display 479 and/or control element 478 can by central processing unit 480 AC ground couplings.

Central processing unit 480 can comprise, and such as, one or more microprocessor, and/or other electronic sections such as data cube computation element, store, non-transitory computer readable medium etc.In certain embodiments, central processing unit 480 can comprise general purpose computer.CPU 480 also comprises machine readable storage device, such as nonvolatile memory, static RAM (SRAM), dynamic ram, ROM, CD-ROM, dish, tape, magnetic memory, optical memory, flash memory or other machinable medium. accessed and/or by central processing unit for processing from the information of antenna and/or sensor in certain embodiments, to guide described robot arm and/or device of dissecting.

Fig. 4 b depicts the alternative embodiment of a robot arm 472, and this embodiment can comprise the robot arm 472 of an endoscope snake sample with system 400 with robot arm 472 and also comprise a tissue at its end and to dissect device 401b.An embodiment strictly according to the facts in Fig. 4 a, tissue dissect device 401b can optionally be coupled with robot arm 472 or, in addition, being coupled with robot arm 472 of overall or non preference.More detailed information about robotic surgery parts and various embodiments disclosed herein can find by described U. S. application number below, it is each is incorporated herein by reference its entirety at this: 4, 259, 876 title mechanical arms, 4, 221, 997 are called that revolute robot is identical in motion with method, 4, 462, 748 title industrial robots, 4, 494, 417 title flexible arms, especially a kind of robots arm, 4, 631, 689 titles are won the championship elder sister robot, 4, 806, the device of 066 title robot arm, 5, 791, 231 title surgical robot systems and hydraulic actuator Therefor, 7, 199, 545 title automatons are applied for surgery, 7, 316, the hinged surgical instruments of 681 title has for Performing minimally invasive surgery and strengthens flexibly and sensitivity, 8, 182, the system and method for 418 titles illustrates a kind of elongated main body, 8, 224, 485 title Serpentis sample robot arm and removable reshaperes.

In contemplated embodiments, speaking of embodiment that Fig. 4 a mentions when Fig. 4 b can use with speaking of together with pointed shape embodiment that Fig. 1 mentions with 3 time; Also comprise alternative embodiment in addition, such as, the geometry of tip region can comprise not along the protuberance (from depression angle) of the axis of handle; The relevant alternative embodiment of some such tip region geometry at Fig. 5 a, shown by b, c, d.

Any above tissue spoken of is dissected the embodiment of device and/or tissue modification rod, and include but not limited to Fig. 1 a-L, Fig. 2 a-L, Fig. 3 a-L, waits the embodiment spoken of, can to one or more relevant at Fig. 4 a and/or 4b disclosed in robotic surgery element be combined.Most advanced and sophisticated 401a and/or 401b can comprise any tissue dissect device/tissue modification rod particular and/or its device of dissecting/amendment side is most advanced and sophisticated any tip.

In Fig. 5 a, b, c, d, can being applicable in any embodiment discussed in this article of the tip that expection is depicted.Described tip is not limited to symmetry and/or pattern and/or size. and described tip can be asymmetric or lacks protuberance and/or lack or the crack fragment of another side in other embodiments.

Fig. 5 a is upper plane figure, and the tissue showing an embodiment of projection and cracking section is dissected device, and it is characterized in that, protuberance described in some and cracking section are along non axial direction orientation.This embodiment comprises multiple axial protuberance 504a (axially referring to organize the axle of device handle of dissecting at least substantially parallel to corresponding) this embodiment and also comprises multiple non axial protuberance along most advanced and sophisticated right side and multiple non axial protuberance along most advanced and sophisticated left side.This tip also comprises two non axial turning protuberance 554a.This tip also comprises multiple depression.One or more depression may further include cracking section 553a.

In this embodiment, non axial protuberance 551a extends along the direction of substantially vertical and axial protuberance 504a.More specifically illustrate there are two groups of non axial protuberance 551a (of the embodiment demonstrated in Fig. 5 a one on right side is in left side).Two groups of non axial protuberance 551a extend (longitudinal axis along organizing device tip of dissecting) along the direction of substantially vertical and axial protuberance 504a.In addition, can find out in Fig. 5 a that the direction that two groups of non axial protuberance 551a extend is at least roughly mutually contrary.

In certain embodiments, axial protuberance 504a can extend at least substantially identical with the longitudinal axis of handle direction.As above spoken of, and the extending direction of non axial protuberance 551a can form the angle of zero to three ten degree with axial protuberance 504a extending direction.Expection may favourablely allow some application and embodiment provide non axial tip-extension in such scope consequently, such as, allow surgeon with tissue dissect device and/or tissue modification rod carry out efficiently can back and forth with arrive while (" windscreen wiper ") action.

In certain embodiments, tip size can be 1 cm width and about 1-2 mm of thickness.To five/5ths times of such sizes also come in handy place.

In certain embodiments, this tip can be independent parts, and this tip is fixed on handle by multiple method, such as fastening mechanism, fit, plastics sonic welded etc.Or in other embodiments, tip can be the part for handle or the continuity of handle made with similar iron material.In certain embodiments, most advanced and sophisticated also can by being insulation and the material of conductor low in calories forms; Such as, porcelain, pottery, glass ceramics, plastics, various politef, carbon, graphite and graphite-fiberglass complex.In certain embodiments, tip can be made up of the carrier matrix of megohmite insulant (such as, pottery or glass material, such as aluminium oxide, zirconium oxide).Say moral external power control bundle to be connected with conductive element, to lead the electric cracking element 553a of the recess of RF electrosurgical energy through handle to protuberance 551a from Electrosurgical generator before.In certain embodiments, protuberance can comprise bud shape protuberance.In certain embodiments, can there be the recess of 3 to 100 non axial protuberances and pictograph at tip.In an illustrated embodiment, this most advanced and sophisticated 501a can local or be all made up of the layer of the material of the wafer of concentric lamination or annealing in addition; Plastics can be comprised, silicon, glass, glass/ceramic, ceramic metal or pottery.Cracking element 553a also can locally or all be made up of cermet material.Or in another embodiment, end can be constructed by the metal or conductive material that cover insulator.This cracking section can be positioned at the end of conducting element.

In an illustrated embodiment, most advanced and sophisticated 501a ends at such as 504a and 551a protuberance.This tip can by not only non-conductive but also be made up of the material of lower thermal conductivity; Such as porcelain, epoxy resin, pottery, glass-ceramic, plastics or multiple politef.Or tip can be made up of metal or conductive material, it insulate wholly or in part.

In certain embodiments, conductive tissue cracking element 552a can have any geometry, comprises a thin columned line; Tissue Lysis element can be plate shape or planar shaped or linear.This element by non-fusible under any operating condition and can not toxic residua metal or alloy form.Ideal material can include but not limited to steel, nickel, alloy, palladium, gold, tungsten, silver, copper and platinum.Thus metal oxidizedly can stop electric current and its function.

Fig. 5 b is upper plane graph, shows another tissue and to dissect the protuberance of embodiment of tip region of device and cracking section.This embodiment can comprise the multiple non axial protuberance of multiple axial protuberance 504b and 551b.In addition, this embodiment comprises two transition or turning protuberance 554b.Multiple depression 552b also shows, and one or more in them can comprise corresponding cracking section 553b.

Fig. 5 c is upper plane graph, shows a tissue and to dissect the protuberance of embodiment of tip region of device and cracking section.This embodiment comprises multiple axial protuberance; This embodiment also comprises multiple non axial protuberance 551c along most advanced and sophisticated right side and multiple non axial protuberance along most advanced and sophisticated left side.Tip also comprises two non axial horn shape protuberances.This tip also comprises multiple depression 552c.One or more depression may further include cracking section 553c.

Fig. 5 c is lower plan view, shows another tissue and to dissect the protuberance of embodiment of tip region of device and cracking section.This embodiment can comprise most axial protuberance and the non axial protuberance 551d of majority.In addition, this embodiment comprises two transition or horn shape protuberance.Most depression 552d is also shown, and one or more can comprise corresponding cracking section.The tip of Fig. 5 d comprises antenna 518d further.In shown embodiment, antenna 518d can be included in any antenna that other places are mentioned herein and comprise such as any antenna of speaking of relevant with antenna 118.Comprise in the embodiment of a RFID label tag at antenna 518d, described RFID label tag can comprise a RFID transponder.

Some embodiment can configure the data from antenna being further and jointly can use with the sensing data from device of dissecting.Such as, some tissue comprising one or more sensor dissect device embodiment can further with one or more antenna configurations.As such, the data from one or more sensor can use together with the data from one or more antenna.Such as, some embodiment can be configured to be supplied to the information from one or more sensor of surgeon from one or more health seat.Further illustrate with an example, the information of a protein of concerns about bio tissue and/or the content of nucleic acid can be combined with the information at the seat of its detection level.

Fig. 6 is an example of an application of method 600.According to disclosure literary composition, this application is the device in order to Fig. 1 a-j shows, and its device sensor with following methods sampling and/or can analyze tissue/fluid.One can be detected a specific biochemistry and/or biomarker and sterilely can be positioned over a sterile tissue and to dissect the base of device.Then patient can be cleaned can carry out anaesthetizing and inlet slit.Step 605 can comprise and device of dissecting is inserted into patient and guides device of dissecting towards will the sampled and/or destination organization analyzed.Step 610 can comprise and starts described antenna and an adjoint CPU, so that the position of tracking transducer and device of dissecting.Step 615 can comprise in some applications and starts fiber optics and/or a video camera to provide further data, the such as view data of associated sensor and device of dissecting.Step 620 can comprise when device of dissecting arrives at the seat of desirable sampling/analyze, and can get involved the space of one or more fluid to upper cover and base if necessary to promote sample of tissue and/or analysis.

Step 625 can comprise the described sensor of exposure.In some applications, described sensor can expose by opening and/or retract upper cover.In some applications, sensor can by expose from upper cover is outstanding at least partially, as herein elsewhere as described in.Step 630 can comprise and described sensor is positioned at desirable place/angle to increase the desired contact with intended body fluid and/or tissue.In some applications, such seat/angle can increase the contact between target fluid and/or tissue.In some applications, can utilize generator that sensor is positioned at desirable seat/angle.Step 635 can comprise stimulating and/or shake to organize dissects rod to increase the contact between sensor and target fluid/tissue further.Such as, in the embodiment comprising such vibrating method, such method can be activated so that shaking sensor so that increase contact and/or sample of tissue.As herein elsewhere as described in, such vibrating method can position in the adjacent of lever or the inside to provide suitable vibrations in not histoclastic situation.

Step 640 can comprise enable sensor keep in the target area with sample contacts, until obtain a kind of accurate and/or stable reading.In some applications, sensor can be configured to maintain such contact in predetermined time section.In some embodiments of method 600, sensor is allowed to keep and the contacting to comprise and keep such contact within a certain period of time of sampling.Step 645 can comprise makes sensor not expose.In the application that sensor is outstanding, step 645 amount of money has comprised to be regained sensor in upper cover.In the application that upper cover is opened, step 645 can comprise closedown upper cover.Step 650 can comprise biological substance and/or the sensing data of process collection.If dissected, rod also needs process collection of material and/or sensing data further when target area, and so described processing procedure can be carried out at base after sampling.In some applications, one or more external fluid and/or reagent can be transported to base promotion chemical reaction and/or effect.

Step 655 can comprise cleaning sensing, such as cleaned in order to next target area reuses.In some applications, one or more fluid, such as abluent (or water) can add promotion cleaning in base.If needed, such fluid also can utilize vacuum ports to take out from base, as described elsewhere herein.

Step 660 can comprise for another operation preparation sensor.In some applications, cleaning can with regeneration combining step.In some applications, step 669 comprises regeneration sensor instantly.In other application, step 660 can comprise the new sensor of exposure one.After the sensor that sensor is reproduced or is new is exposed, tissue dissect device/tissue modification rod can be moved by surgeon and/or trace into next Target Station and repetitive process so that further sampling/analyze.

Show in Fig. 7 according to utilizing the application organizing a rod contact organ method 700 of dissecting in disclosure book.In some applications, surgeon may need to touch tissue and/or organ to repair or and treatment.In some applications, the skin around otch cleanedly can such as use isopropyl alcohol (degreaser), then disinfecting scrub acid chlorhexidine.Then, a local anesthetic can apply (as by injection) 1% lignocaine+1: 10000 epinephrine to skin.

Step 705 can comprise, and in order to minimally invasive surgery or Micro trauma inlet slit, opens a limited otch and passes through to allow the dissect tip of device or the Breadth Maximum of axle of tissue.Step 705 can be carried out together with such as #15 Ahmedabad park's operation cutter.This otch can use scalpel, and shears or other surgical units are deepened.For larger operation, such as abdominal operation or trauma operation step 705 can comprise initial skin incision or body cavity opening procedure.In some applications, step 710 can comprise the dissect cracking section of device of using-system and opens skin incision.Step 710 can comprise: apply one or more fluid to skin.In some applications, step 710 can comprise destination organization applying fluid.In some applications, step 710 can comprise and directly to apply outside fluid to destination organization or in addition, between the tissue of process apply fluid.In some applications, fluid can comprise water.In some applications, fluid can comprise an ion type liquid, as normal saline solution.Described fluid can by such as injecting, or tissue is dissected device fluid port or by independent sleeve pipe or conduit or by toppling over or being applied to tissue by spraying.In some applications, fluid can comprise an ion-type fluid and an anesthetis, such as a swelling anaesthesia.Nonionic fluid also may be used in other application; This fluid can become more ion-type fluid because of the example of the patient of operative region.In some application, it is one or more as ion fluid that step 710 can comprise applying, and/or anesthetis, and/or adrenergic fluid.In the application that some are such, fluid can comprise Klein Gordon equation formula. in some applications, Klein Gordon equation formula and consumption can about 100cc Klein Gordon equation formula and saline, 0.1% lignocaine, epinephrine 1:1,000,000 and the saline of Na+-HCO3@5meq/L).Step 715 can comprise: create by multilayer tissue the road that arrives Target organ with organizing device of dissecting.In some applications, Make Path Target organ or other destination organization can comprise creation path from otch to Target organ or other destination organization and/or surrounding target organ or other destination organizations create a path to allow other region close to Target organ or its destination organization.In some applications, step 715 also comprises and starts cracking section and/or energy window to reduce hemorrhage or to arrive the tissue of Target organ process.In some applications, cracking section and/or energy window can be used for promoting fibrosis along path, comprise the path along the periphery that can cross Target organ/tissue.In some applications, the dissect route of device and/or expection of described tissue can utilize such as endoscope, a fiber optics or photographing unit, an antenna or other device views.In some applications, such a device or devices can be dissected on device in tissue position.In other are used, such device or devices can dissect device separately with tissue.In some applications, device of dissecting may produce the tissue of heat or the process that releases energy.In some applications, organize the heating part of the tissue of device process of dissecting possibility undesirable.Therefore in some applications, undesirable heating can be alleviated by organizing device conveying capacity of dissecting to apply cooling step simultaneously or before.Such step can comprise dissect device or one or more independently conduit or intubate or endoscope of use and carry one or more cooling fluid.Described chiller can comprise such as, a closed water bag.Under such bag can be less than the temperature of 37 DEG C.In some applications, cooling object, as liquid or gel-filled bag can serviceability temperature scope in 1 DEG C-20 DEG C.In such application, fluid or gel can about 15 DEG C.Other chillers can comprise a dynamic cooling system, and one of them cold fluid or gel pump into or pass through the cooling of articles of contact.Step 720 can comprise the anatomical structure identified in important blood vessel, nerve, conduit, organ or other destination organization peripheral region.Step 725 can comprise: add the fluid of more described types before to target and/or surrounding tissue; Fluid will to be dissected device port and or being arrived at by one or more independently conduit or sleeve pipe or endoscope by tissue.Step 730 can comprise: the region expanding the path of one or more arrival destination organization.In some applications, step 730 can comprise expansion one or more from otch to destination organization path.In some applications, step 730 can comprise a region around expansion destination organization, such as, draw fan-shaped action by one.In some applications, the dissect step of device of one or more using-system spoken of in addition at this also can be drawn fan-shaped action and carried out.Having axial protuberance tissue in use dissects in the application of device, and so fan-shaped action can comprise spoke wheel rule back and forth.Have non axial protuberance tissue dissect in the application of device in use, so fan-shaped action can comprise one arrive while fan-shaped action; Use the action having the fan-shaped action of dissecting in the example of device of at least one non axial protuberance tissue and comprise " windscreen wiper " form.In some applications, step 730 may further include and starts the energy Ratios of device of dissecting as the energy of cracking section and/or one or more energy window.Step 735 can comprise: observe on demand to have and have no way of larger angiorrbagia and keep hemostasis.In some applications, hemostasis can by ironing, shocking by electricity, colligation, or chemical method is reached.In some applications, described cracking section and/or energy window can be used for reaching haemostatic effect.

In some applications, other devices one or more and/or suture and/or surgical both hands can be used for realizing the hemostasis compared with trunk.Step 740 can comprise: remove tissue and to dissect device powered-down sew on wound by definitely mode.In some applications, the tissue of process may need by sewing up and/or coincideing so that close.In some applications, tissue device of dissecting the organ of useful help and/or tract can include but not limited to muscle and/or the parotid gland and/or salivary gland and/or thyroid and/or lung, and/or heart and/or gastrointestinal tract, and/or liver) and/or pancreas and/or spleen, and/or gallbladder, and/or kidney, and/or adrenal gland and/or carcinoma of prostate and/or ovary and/or uterus and/or bladder and/or blood vessel, and/or lymph node and/or skeleton and/or pulmonary carcinoma.

Fig. 8 shows using-system and to dissect the flow chart of application of method 800 of device sampling and/or test organization.In this application, the data splitting from least one sensing ratio and antenna (one or more) organizing device of dissecting to produce can be used for providing suitable feedback to user in therapeutic process.In some applications, device of dissecting is organized can to comprise the tip that comprises most protuberance.One or more cracking section can in most protuberance between at least every two adjacent protrusions.A sensor, such as a nano-sensor, can be positioned at tissue and dissect on device.This sensor can be configured to the content of sensing chemistry and/or biologic artifact.Its chemistry and/or biologic artifact must be included in intra-operative at least one tissue adjacent with rod of dissecting and fluid.The fluid that chemistry and/or biologic artifact content are read can comprise, such as, from adjacent tissue and/or by organizing the fluid of dissect device and/or other devices or process intervene operation.This operation device of dissecting can also comprise an antenna (one or more) such as one RFID label tag being positioned at tissue and dissecting on device.In some applications, described antenna can be positioned at the end of tip and/or handle, as most advanced and sophisticated bottom and/or handle end.This antenna can be mixed with the section of providing tissue and to dissect the locator data at device seat, such as, dissect in an operation part for device or the seat in a region.Although method 800 demonstrates in the figure of step 805, but what be worth understanding is that above any preliminary step described together with other are applied also also can be able to perform in method 800. such as, the step (705-730) if necessary in one or more method 700 can perform in method 800.Identical, one or more other steps that he applies described here also all can be included in the method that Figure 18 demonstrates.In some applications, step 805 can comprise: tissue receiving is dissected the data of device sensor.Step 810 can comprise the data receiving the antenna that RFID label tag is so freely.Step 815 can comprise the data merged from least sensor and antenna.In some applications, the data coming sensor and antenna can be merged before reception.In other words, " tissue receiving dissect the merging data from least sensor and antenna that device produces " step can comprise data that reception merged (data are from the data of the described sensor merged before receiving and described antenna) or can comprise the data receiving separately sensor and the data accepted separately from antenna in addition, and its data received can allow one or more specific effect or speciality.The data merged can use user to judge in one or more patient body by the region of organizing device of dissecting fully to test and/or sample to help permission surgeon or other.Such as, the data merged in some applications make user see region in one or more patient body, the region of such as one or more abundant treatment.This can pass through, and such as, creates one and the corresponding image in the one or more region of patient body.This image can be highlighted, accept color change, or which region amendment demonstrates and fully tested or sample on one display.In some applications, this region can be corresponding with the region reaching certain chemistry and/or biologic artifact content and/or biomarker content.

Some embodiments can be configured with detector and/or optical scanner, are set to from certain organs or tissue detection reflected light.Such as, some embodiments can be configured to launch and direct light or other electromagnetic radiation to organ or tissue and scanning reflection light to assess the type of the organ-/ tissue of reflected light/radiation.Some such embodiments can comprise as multispectral polarized light scatter/scanning system, and as U.S. Patent Application Publication No. 2012/0041290 title " inside peeping the multispectral light scattering scan method of polarization, ", which is hereby incorporated by reference for the document.

In such an application, from detector/scanner can with the data assemblies from other device/parts one or more, its device/part as a RFID label tag or other antennas, to provide further details to surgeon in using-system dissects device/tissue modification rod operation.Such as, comprise in the embodiment of an optical detector/scanner as above at some, can be used for identifying from reflected radiation source data and organize the organ that device of dissecting/amendment rod is adjacent.These data can merge with the locator data of antenna to be supplied to surgeon about the seat of organizing device of dissecting/tissue modification rod in patient body and the seat of organizing device of dissecting/amendment rod corresponding to the organ or tissue of detection.Such as, tissue is dissected, and device/amendment is excellent is prompted to surgeon close to or far away from what can provide vision or audition when liver.In certain embodiments, organize surgeon can be provided more detailed information, as the distance instantly from organ, direction arriving organ etc. when not injuring other organ-/ tissues.In certain embodiments, one or more sensor 110,112,210,214,310 and/or 314 can comprise such detector/scanner.In certain embodiments, the process of a part for reflected radiation can be completed by tissue device/amendment rod of dissecting.But in other embodiments, described tissue device/amendment rod of dissecting only includes one or more optical fiber element, as herein elsewhere as described in.This pipeline element can be configured to the radiation of reception reflection and transmit another system that it arrives extracorporeal, and such as one is configured to the computer system processing reflected radiation data.At female hematochrome particle, described one or more optical fiber element can also be configured to discharge the radiation that will reflect.Or extra fiber optic component and/or other radiation emitting elements can be provided by order for this reason.

Can be used for the example of the reflection of electromagnetic wave technology of embodiments more disclosed herein, such as electromagnetic transfer element (115) and/or sensor 110,114,210,214,310, and/or in 314, can in " the chest laser-bounce imaging for interior structures locating " (for contact optical fiber probe (Kumaravel, the Singh of optical spectra in body; Biomedical engineering, IEEE, 2010,57 (5) 1167-1175.) find, it is incorporated herein by reference in full.

In the example that a method 900 comprising described measuring ability is applied, device of a dissecting/amendment rod can insert in patient body 905.In step 910, radiation source can be activated radiating light or other electromagnetic radiation for sense organ or tissue.In some applications, step 910 may further include the organ or tissue that to be radiated described in guiding and to be identified.In step 915, can be received from the light of radiation source reflection and analyze.As mentioned above, analysis so in some applications can comprise spectrum analysis, such as, use a multispectral polarized light scatter/scanning system.In step 920, the locator data from such as antenna can be received.In some applications, described locator data can merge with the data analyzing reflected radiation.Follow, in step 925, the information comprising locator data and organ-/ tissue identification data can be supplied to user.Such as, as mentioned above, in some applications, step 925 can comprise and is supplied to surgeon about what organ-/ tissue and has been identified and now from the range information of described organ-/ tissue.

Figure 10 shows a modular organization and to dissect the embodiment of device 1000, and its tissue device of dissecting comprises the flexible handle 1002 in 1001, one, a tip, and endoscope's lever 1003.Therefore most advanced and sophisticated 1001 can be separately modular from flexible handle 1002.Most advanced and sophisticated 1001 comprise method that is flexible and handle 1068 coupling specifically.In an illustrated embodiment, this even summation method comprises a most advanced and sophisticated blocking 1068.In certain embodiments, most advanced and sophisticated plug 1068 can have screw thread to guarantee that modularity most advanced and sophisticated 1001 and handle 1002 are firmly coupled.But in other embodiments, coupling process can comprise the recess that is configured to the blocking accepted on handle.In other embodiments, even summation method can comprise snap fit connection, a frictional fit and connect, bayonet socket clip etc.

In an illustrated embodiment, most advanced and sophisticated blocking 1068 is configured to be received by corresponding recess 1069, and its recess is arranged in handle 1002.In certain embodiments, most advanced and sophisticated blocking 1068 can be configured to allow most advanced and sophisticated 1001 and handle 1002 electric coupling.Connect with such form in the embodiment allowing and comprise as cracking section, from the electricity of a power supply by the coupled transfer of blocking 1068 and recess 1069, so that cracking section is energetic.Other embodiment can be configured to transmit extra electric power, data or material by this coupling.Such as, comprise in the embodiment of one or more sensor on most advanced and sophisticated 1001, the signal from these sensors can by described coupling process 1068 through handle 1002.

In certain embodiments, most advanced and sophisticated 1001 can be disposable.One doctor can be changed applicable tip and lose its tip in operation on handle.Or/in addition, most different tip can be provided, and it is each is disposable or can be configured to sterilize and uses; A tip can by choice for use in suitable operation.

In an illustrated embodiment, most advanced and sophisticated 1001 comprise most protuberance 1004, and it is non axial a bit.Most recess 1005 is had, as mentioned above between these protuberances.In certain embodiments, a tip only including axial protuberance can be replaced by most advanced and sophisticated 1001, if in order to a concrete operation if required.

Figure 11 shows a tissue and to dissect the alternative embodiment of device 1100.Embodiment comprises a tip 1101 and endoscope's lever 1103.Device 1100 of dissecting is organized to comprise the handle that comprises canned paragraph 1102a and flexible paragraph 1102b.

Figure 11 embodiment comprise bio-sensing base device 1184 further.Figure 11 embodiment in, base 1184 is positioned at the canned paragraph 1102a of handle 1102.Base 1184 also includes the lid 1180 of the removable method of selectivity, and its lid 1183 for optionally movement can be adjacent with base 1184.The example of this lid moving method can comprise track, groove, track, ratchet, cable, arm, line etc.In the embodiment shown, lid moving method comprises track.A part for described handle can comprise lid moving method 1183 in certain embodiments.Expection in an alternate embodiment, can omit lid moving method 1183.Lid 1180 comprises the front end 1181 of rear end 1182 and point.Canned paragraph 1102a also comprises another energy window 1108 further.Be same as first energy window 1107, it can be positioned at modularity tip 1101.Biosensor base 1184 may further include the characteristic sum part of the base that any other speaks of together with these embodiment parts, comprises fluid transmitting apertures, fluid extraction port, sensor, seat, heater, hybrid element etc.In the embodiment of expection, the first energy window 1107 and/or the second energy window 1108 can be omitted.As the embodiment of Figure 10, the embodiment of this Figure 11 can have a modularity and/or disposable most advanced and sophisticated 1101, suitable tip can be placed on handle by surgeon and also dispose tip after surgery.In addition/or can provide multiple different most advanced and sophisticated, wherein each can be that disposable maybe can being configured to can be sterilized and reuse, and suitable tip can be selected according to need for particular procedure.In the embodiment in figure 11, most advanced and sophisticated 1101 canned paragraph 1102a can be detachably connected to provide such function.

Those skilled in the art can understand above-described embodiment details can not deviate from given herein go out ultimate principle under change.Such as, expection has the combination of the feature of the appropriately combined or embodiment of any various embodiment.

Any method disclosed herein comprises one or more step for performing described method or action.Described method step and/or action can be interchangeable with one another.In other words, unless the proper handling of embodiment needs step or the action of particular order, code and/or clear and definite step and/or operation can be modified.

In whole description, appoint and " embodiment ", quoting of " embodiment " or " this embodiment " are meaned that being combined with described embodiment specific one feature, structure or the characteristic spoken of is included at least one embodiment.What therefore quoted phrase or its modification were described in this manual not necessarily refers to same embodiment entirely.

Be to be understood that in the description of above embodiment equally, various feature is combined in an embodiment, accompanying drawing or its description sometimes, to simplify the disclosure.But the disclosure method should not be construed as any claim and also require more feature except the feature clearly recorded in its claim.On the contrary, inventive aspect is all features being less than any single aforementioned disclosed embodiment.Obviously can know that the details of above-described embodiment can not depart under ultimate principle condition set forth herein and can change for a person skilled in the art.

In addition, described feature, parts, structure, step or characteristic can be combined in one or more alternative embodiment and/or application in any suitable manner.In other words, the feature of embodiment disclosed in any one, parts, structure, step or feature can with the feature of other disclosed embodiments, parts, component, step or property combination.

Claims

1. an operation tool analyzed for biological tissue, is characterized in that, comprising:

A handle;

One is positioned at the distal tip of handle;

Be positioned at a biosensor base on instrument;

And be positioned at the biosensor of base, wherein this biosensor arrangement becomes to provide in operation the information of the relevant patient biological's tissue of at least one and body fluid.

2. operation tool as claimed in claim 1, is characterized in that: be positioned at the biosensor base on handle in operation device.

3. operation tool as described in claim 2, is characterized in that: biosensor bottom susceptor is in the upper surface of handle.

4. operation tool as described in claim 1, is characterized in that: the upper cover also comprising biosensor base, is used for covering biosensor.

5. operation tool as described in claim 4, is characterized in that: the upper cover can selecting the movement relative to biosensor.

6. operation tool as described in claim 5, is characterized in that: also comprise upper cover carries out selectivity movement method relative to biosensor.

7. operation tool as described in claim 6, is characterized in that: upper cover moving method associated components comprises at least one parts in cross bar, groove, track, ratcs and winding displacement.

8. operation tool as described in claim 4, is characterized in that: upper cover is configured to have closed a space at least fully, and biosensor base is refered in particular at least partly by the state closed in this space.

9. operation tool as described in claim 4, is characterized in that: upper cover comprises a part for handle.

10. operation tool as described in claim 9, it is characterized in that: the state that biosensor base is shut is positioned at handle, and the Part I of handle can move relative to Part II, manifest the state that biosensor base is opened.

11. as described in claim 4 operation tool, it is characterized in that: upper cover at least comprises the groove that guides fluid in sensor base.

12. as described in claim 4 operation tool, it is characterized in that: upper cover at least comprises the protuberance that guides fluid in sensor base.

13. as described in claim 4 operation tool, it is characterized in that: upper lid surface at least comprises an opening.

14. operation tool as described in claim 13, is characterized in that: also comprise the vacuum ports of position in biosensor base, the upper cover of this port be configured to isolate an interior space make to produce vacuum after at least one opening have energy-absorbing function.

15. as described in claim 13 operation tool, it is characterized in that: biosensor arrangement becomes just to allow a part for biosensor to emerge at least one opening.

16. as described in claim 15 operation tool, it is characterized in that: biosensor arrangement become at least can allow biosensor a part of washability by least one opening.

17. as described in claim 16 operation tool, it is characterized in that: the pedestal also comprising a biosensor, this pedestal is configured to surely to support to determine biosensor, can also raise to washability biosensor to a specific position, have at least a part to emerge at least one opening to biosensor during this position.

18. as described in claim 15 operation tool, it is characterized in that: at least the part of biosensor comprises fiber optic component.

19. as described in claim 4 operation tool, it is characterized in that: also comprise the electromagnetic type conveying element being positioned at biosensor base.

20. as described in claim 19 operation tool, it is characterized in that: upper cover comprises an inner surface, interior surface is configured to can the electromagnetic radiation that produces of reflected electromagnetic conveying element.

21. as described in claim 20 operation tool, it is characterized in that: inner surface is minute surface.

22. as described in claim 1 operation tool, it is characterized in that: also comprise a biosensor pedestal, this pedestal is configured to stablize and holds on biosensor.

23. as described in claim 22 operation tool, it is characterized in that: biosensor pedestal is configured to stablize biological support sensor more flexibly.

24. as described in claim 22 operation tool, it is characterized in that: biosensor pedestal is configured at least can close fully a part for biosensor.

25. as described in claim 24 operation tool, it is characterized in that: biosensor pedestal comprises the baffle plate that is configured at least can close fully biosensor border.

26. as described in claim 24 operation tool, it is characterized in that: biosensor pedestal comprises an opening, and this opening comprises self-sealing material.

27. as described in claim 1 operation tool, it is characterized in that: biosensor at least comprises nano biological sensor, biological micro-array, optical biosensor, electrochemical biosensor and a piezoelectric biological sensor.

28. as described in claim 27 operation tool, it is characterized in that: biosensor at least comprises a DNA biosensor and a DNA microarray.

29. as described in claim 1 operation tool, it is characterized in that: also comprise an antenna on operation tool, this antenna configurations becomes can provide the locating information that in relevant operation, operation tool is at least part of.

30. as described in claim 29 operation tool, it is characterized in that: antenna comprises a RFID tag.

31. as described in claim 24 operation tool, it is characterized in that: tip comprises most protuberance, and at least between two protuberances, have at least one recess.

32. as described in claim 31 operation tool, it is characterized in that: at least one recess comprises a cracking section.

33. as described in claim 31 operation tool, it is characterized in that: the arrangement of most protuberance arranges along an axis of handle.

34. as described in claim 1 operation tool, it is characterized in that: also comprising one can the fluid delivery ports of conveyance fluid.

35. as described in claim 34 operation tool, it is characterized in that: fluid delivery ports is positioned at biosensor base, so as to give biosensor base transmitting fluid.

36. as described in claim 34 operation tool, it is characterized in that: also comprise a vacuum ports in order to draw fluid.

37. as described in claim 36 operation tool, it is characterized in that: vacuum ports is positioned at biosensor base so that from biosensor base draw fluid.

38. as described in claim 1 operation tool, it is characterized in that: also comprise so that the temperature control method regulating the temperature in biosensor base and exist.

39. as described in claim 38 operation tool, it is characterized in that: temperature control method comprises a heater.

40. as described in claim 1 operation tool, it is characterized in that: also comprise the blender that is positioned at biosensor base.

41. as described in claim 1 operation tool, it is characterized in that: also comprise an energy window, this energy window be configured to can in operation to operation tool contact biological tissue transmit energy.

42. as described in claim 41 operation tool, it is characterized in that: on the handle of energy window position outside biosensor base.

43. as described in claim 42 operation tool, it is characterized in that: energy window comprises a ultrasonic energy window.

44. as described in claim 41 operation tool, it is characterized in that: energy window comprises a radio-frequency (RF) energy window.

45. operation tool as described in claim 43, is characterized in that: ultrasonic energy window is configured to the strength and the frequency that allow the ultrasonic energy optionally regulating at least one ultrasound wave amount window to send out.

46. as described in claim 1 operation tool, it is characterized in that: also comprise one just to shake the vibrating method of operation tool in operation.

47. as described in claim 46 operation tool, it is characterized in that: vibrating method comprises at least one piezoelectric type actuator, ultrasonic motor and vibrations motor.

48. operation tool as described in claim 46, is characterized in that: also comprise a handles, and handle is positioned at the end of this handle, and vibrating method to be positioned at inside handle or above.

49. as described in claim 1 operation tool, it is characterized in that: biosensor base comprises at least one groove, this groove is configured to guide direction of flow in biosensor base.

50. as described in claim 1 operation tool, it is characterized in that: biosensor base comprises at least one protuberance, this protuberance is configured to guide direction of flow in biosensor base.

51. 1 kinds of biological tissue's analytical methods, its method step comprises, and it is characterized in that:

Patient skin is opened an otch;

Insert operation tool from otch, its operation tool comprises, and it is characterized in that:

A handle;

One is positioned at the distal tip of handle;

Be positioned at a biosensor base and the biosensor being positioned at base on instrument;

Tissue and the tissue fluid of at least one patient is taken out through patient biological's tissue from biosensor base with operation tool;

The information of the relevant patient biological's tissue of bioanalysis at least one and body fluid is carried out with biosensor;

Preserve the data of bioanalysis and take out operation tool in patient body.

52. as described in claim 51 method, it is characterized in that: preserve the data step of bioanalysis and comprise data are passed to the medium that available computer reads.

53. as described in claim 51 method, it is characterized in that: preserve the data step of bioanalysis comprise operation tool in patient body time preserve the data of bioanalysis.

54. as described in claim 51 method, it is characterized in that: operation tool also comprises a ultrasonic energy window, also comprises:

Start ultrasonic energy window first energy rank;

The first energy rank of ultrasonic energy window is used to go close at least one organ and biological tissue;

Start ultrasonic energy window the and energy rank, it is characterized in that: the second energy rank light rain first energy rank; Go to disturb the cell of at least one organ and biological tissue to promote close to more cell with using the second energy rank of ultrasonic energy window.

55. as described in claim 54 method, it is characterized in that: also comprise the sample cell of taking out from least one organ and biological tissue.

56. as described in claim 55 method, it is characterized in that: comprise cell is recovered to biosensor base when at least one organ and biological tissue's sampling sampling.

57. as described in claim 51 method, it is characterized in that: operation tool comprises the upper cover of a biosensor base, and organize the tissue that takes out at least one patient and tissue fluid to be recovered to biosensor base step with operation tool through patient biological.

58. as described in claim 57 method, it is characterized in that: opening biosensor base to expose biosensor comprises use a pair railing and regain biosensor base.

59. as described in claim 51 method, it is characterized in that: operation tool also comprises a biosensor base upper cover, this biosensor base upper cover comprises at least one opening, and organizes the tissue that takes out at least one patient and the tissue fluid biosensor be recovered in this step of biosensor base to have at least a part to emerge the opening of upper cover with operation tool through patient biological.

60. as described in claim 51 method, it is characterized in that: operation tool also comprises one and is configured to receive the pedestal of biosensor.

61. as described in claim 60 method, it is characterized in that: also comprise inclined base and go to change the direction of biosensor.

62. as described in claim 51 method, it is characterized in that: also comprise and transmit one or more fluids to biosensor base.

63. as described in claim 62 method, it is characterized in that: also comprise and fetch one or more fluids to biosensor pedestal.

64. as described in claim 51 method, it is characterized in that: operation tool also comprises an antenna.

65. as described in claim 64 method, it is characterized in that: also comprise and send signal from antenna, the information that this signal provides operation tool to locate at that time.

66. as described in claim 65 method, it is characterized in that: the associating of the image of the data that signal provides and patient body, makes surgeon can imagine the relevant position of operation tool in patient body.

67. as described in claim 51 method, it is characterized in that: biosensor at least comprises a nano biological sensor, biological micro-array, optical biosensor, electrochemical biosensor, and piezoelectric biological sensor.

68. as described in claim 67 method, it is characterized in that: biosensor comprises at least one DNA biosensor and a micro-array of DNA.

69. as described in claim 51 method, it is characterized in that: be also included at least one biological tissue of heating and fluid in biosensor base.

70. method as described in claim 51, is characterized in that: operation tool also comprises a radiation sensor, also comprise the step using this radiation sensor to go to check the radiation of at least one in patient body.

71. method as described in claim 70, is characterized in that: operation tool comprises the fluid transmit port being positioned at biosensor base, its port is used for described in transmitting fluid to biosensor base; And use radiation sensor to go to check the step of the radiation of at least one in patient body, it is characterized in that, comprising:

By fluid transmit port incoming gas to biosensor base, its gas comprises special nanoparticle;

The particle be ionized from gas is collected at least one electrode; With

The signal of telecommunication that process produces because collecting the particle that is ionized from least one electrode.

72. 1 carry out biological tissue's analysis operation tool, it is characterized in that, comprising:

A handle;

One is positioned at the distal tip of handle;

Most advanced and sophisticated most protuberances;

Many places recess between adjacent protrusions;

Each cracking section being positioned at recess;

Biosensor base on instrument;

Be configured to the upper cover optionally moving to closed condition from open mode; With

Be positioned at the biosensor in biosensor base, it is characterized in that, biosensor arrangement become can provide at least one is relevant perform the operation in the biology of patient rent the information with body fluid, its feature also in, operation tool be configured to when biosensor upper cover be in open seat time, this biosensor can touch biological tissue.

73. as described in claim 72 operation tool, it is characterized in that: tip comprises at least one substantially flat upper surface and an at least substantially flat lower surface.

The analytical method of 74. 1 biological tissues, its method step is characterised in that, comprising:

Patient skin creates otch;

Insert operation tool from otch, its operation tool is characterised in that, comprising:

A handle;

One is positioned at the distal tip of handle;

Be positioned at a biosensor base on instrument;

The upper cover of biosensor base; With

Be positioned at the biosensor of base;

Organize through patient biological with operation tool;

Biological tissue is contacted with operation tool;

The bioanalysis of patient biological's tissue is carried out with biosensor;

The preservation of biological analysis data; With

Operation tool is taken out in patient body.

75. as described in claim 74 method, it is characterized in that: also comprise the biological tissue that wins patient and place it and be organized in biosensor base.

76. as described in claim 74 method, it is characterized in that: it is preserved biological analysis data step and comprises: preserve biological analysis data when biological tool is in patient body.

77. 1 methods of carrying out robotic surgery, its method step is characterised in that:

Utilize robotic surgical system that operation tool inserting is entered the otch into patient, its operation tool feature comprises:

A tip;

Biosensor base on instrument; With

Be positioned at the biosensor of biosensor base;

Its robotic surgical system is characterised in that, comprising:

A robot arm, this arm is configured to allow surgeon indirectly to use operation tool to perform the operation, and it is characterized in that: its tip is positioned at the end of robot arm; With

A manipulation element allowing surgeon to manipulate robot arm

Utilize robot arm that operation tool is organized through patient biological;

Robot arm is utilized to win the biological tissue of at least one patient and a kind of fluid and be positioned over biosensor base;

Utilize biosensor to carry out bioanalysis, analyze at least one biological tissue and a kind of fluid;

Preserve the data of bioanalysis; With

Operation tool is taken out in patient body.

78. as described in claim 77 method, it is characterized in that: preserve biological analysis data this step and comprise the data of just preserving bioanalysis when operation tool is in patient body.

79. 1 operation tools, comprising:

A handle; With

Be positioned at the tip of handle tip, it is characterized in that: tip comprises most protuberance and between adjacent protrusions, has a recess at least, is further characterized in that: a part for handle is flexibly, make the relative handle of most advanced and sophisticated energy towards most direction.

80. operation tool as described in claim 79, is characterized in that: tip is modular, be namely configured to take off old tip from handle, change new tip.

81. as described in claim 80 operation tool, it is characterized in that: the most advanced and sophisticated method combined with handle with also comprising extraction-type.

82. operation tool as described in claim 81, is characterized in that: removably comprise a connector in conjunction with the method for described tip and described handle and be configured to be contained in a groove.

83. as described in claim 82 operation tool, it is characterized in that: be blocked in most advanced and sophisticated formation.

84. as described in claim 79 operation tool, it is characterized in that: operation tool comprises an endoscope.

85. as described in claim 79 operation tool, it is characterized in that: handle comprises a firm section.

86. as described in claim 85 operation tool, it is characterized in that, also comprise:

Be positioned at the biosensor base on instrument; With

Biosensor in biosensor base, is characterized in that: biosensor arrangement becomes can provide about an information in the biological tissue of patient in operation process and the information of fluid.

87. as described in claim 86 operation tool, it is characterized in that: biosensor is positioned at firm section.