CN105175224B - Preparation method of low-residue granular sodium alkoxide or potassium alcoholate - Google Patents
Preparation method of low-residue granular sodium alkoxide or potassium alcoholate Download PDFInfo
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- CN105175224B CN105175224B CN201510553662.6A CN201510553662A CN105175224B CN 105175224 B CN105175224 B CN 105175224B CN 201510553662 A CN201510553662 A CN 201510553662A CN 105175224 B CN105175224 B CN 105175224B
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- C07—ORGANIC CHEMISTRY
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- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/68—Preparation of metal alcoholates
- C07C29/70—Preparation of metal alcoholates by converting hydroxy groups to O-metal groups
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Abstract
The present invention provides a preparation method of low-residue granular sodium alkoxide or potassium alcoholate. According to the method, a corresponding alkali of sodium or a corresponding alkali of potassium and an alcohol are adopted as raw materials, the raw materials are mixed with a solvent, a reaction is performed by using a microwave heating manner, and the remaining alcohol and the remaining solvent are removed under the microwave effect after completing the reaction to obtain the granular sodium alkoxide or potassium alcoholate, wherein the microwave frequency is 2450+/-50 MHz. According to the present invention, with the method, the low solvent residue sodium alkoxide or potassium alcoholate production can be achieved, the produced sodium alkoxide or potassium alcoholate is the large particle solid, and the crossover from the existing powder product to the granular product is achieved so as to concurrently solved the solvent residue problem and the use safety danger problem troubling people for a long time are solved. .
Description
Technical field
The invention belongs to chemical field, it is related to sodium alkoxide, potassium alcoholate and in particular to a kind of low-residual graininess sodium alkoxide or potassium alcoholate
Preparation method.
Background technology
Sodium alkoxide, potassium alcoholate are a kind of industrial chemicals highly useful in fields such as medicine, pesticide, dyestuffs.Synthesis with regard to it
Method mainly has two methods according to main material used classification.The first is metal method, that is, with metallic sodium, metallic potassium and phase
The alcohol reaction answered generates corresponding sodium alkoxide, potassium alcoholate；Second method is alkaline process, that is, with sodium hydroxide, potassium hydroxide, amino
The sodium alkoxide of sodium, potassamide and low-molecular-weight, potassium alcoholate react the corresponding sodium alkoxide of generation, potassium alcoholate with alcohol.Both approaches are each favourable
Disadvantage, all industrially applies at present, and maximum shortcoming is that the solid sodium ethanol that generates of two methods, potassium alcoholate dissolvent residual are higher, such as
Produce sodium tert-butoxide with both approaches, potassium tert-butoxide is also easy to produce the tert-butyl alcohol and the complex of sodium alkoxide, potassium alcoholate, is difficult to obtain pure
Sodium alkoxide, potassium alcoholate.In order to obtain the product of low-residual, people adopt the methods such as fine vacuum, high temperature, the drying equipment with pulverizing, though
So also can reduce dissolvent residual but result in another drawback it is simply that the solid sodium ethanol generating, potassium alcoholate are fine powdered,
Granularity is very little, about about 100 mesh, is also easy to produce dust, easily sucks the respiratory tract of user, easily injures the eyes of user,
In the chemical reaction of some sticky systems because it compares conglomeration easily it is not easy to mix with system lead to reaction not exclusively or
Reaction yield is low.With people to product quality, reaction yield, labor protection strict demand, dissolvent residual is high and powder is micro-
The problem that this two shortcomings little have also become sodium alkoxide, potassium alcoholate production industry to pay much attention to, is sodium alkoxide, the concern of potassium alcoholate manufacturing enterprise
A difficult problem with research.
Content of the invention
Based on low-residual in sodium alkoxide in prior art, potassium alcoholate production process and granulating implacable lance therebetween
Shield, the present invention provides the preparation method of a kind of low-residual graininess sodium alkoxide or potassium alcoholate, solves technique of the prior art and is difficult to make
Standby granular sodium alkoxide, potassium alcoholate, and also in granulated product to be ensured solvent low-residual.
In order to solve above-mentioned technical problem, the application adopts the following technical scheme that and is achieved：
A kind of low-residual graininess sodium alkoxide or the preparation method of potassium alcoholate, the method with the corresponding alkali of sodium or the corresponding alkali of potassium with
Alcohol is raw material, mixes with solvent, is reacted by the way of microwave heating, reacts elimination reaction under microwave action after terminating
Remaining alcohol and solvent, obtains graininess sodium alkoxide, potassium alcoholate.
The present invention also has following distinguishing feature：
Specifically, the corresponding alkali of described sodium is sodium hydroxide, Sodamide., Feldalat NM or Sodium ethylate；Described potassium corresponds to
Alkali be potassium hydroxide, potassamide, Feldalat KM or potassium ethoxide；
Specifically, described alcohol is the alcohol of the alcohol, the alcohol of side chain or ring-type of straight chain.
Preferably, the alcohol of described straight chain is methanol, ethanol, propanol or butanol；The alcohol of described side chain is isopropanol, 2-
Butanol, the tert-butyl alcohol or tert-pentyl alcohol；The alcohol of described ring-type is Hexalin.
Specifically, the corresponding alkali of described sodium or the corresponding alkali of potassium are 1 with the mol ratio of alcohol：(1.05～30).
Specifically, described solvent is reaction raw materials alcohol itself or the varsol higher than alcohol boiling point, aromatic hydrocarbon solvent, has
Machine Ammonia solvent or ether solvent.
Preferably, described varsol is linear paraffin, branched paraffin, cyclic alkane or unsaturated olefin；Described
Aromatic hydrocarbon solvent is benzene,toluene,xylene, trimethylbenzene, ethylbenzene, diethylbenzene or isopropylbenzene；Described organic Ammonia solvent is one
Level amine, secondary amine, tertiary amine, ring-type secondary amine or cyclic tertiary amine；Described ether solvent is fatty alcohol ether, fragrant alcohol ether,
Cyclic ethers or dioxy cyclic ethers.
Specifically, described other mode of heatings can also be adopted during being reacted by the way of microwave heating
Carry out auxiliary heating.
Specifically, the temperature control of described reaction temperature and removing alcohol and solvent is at 50 DEG C～150 DEG C；Described removing
The Stress control of alcohol and solvent is in -0.5mmHg～normal pressure.
Specifically, described microwave frequency is 2450 ± 50MHz.
Compared with prior art, beneficial has the technical effect that the present invention：
The method of the present invention is capable of low solvent residue sodium alkoxide, potassium alcoholate produces, and the sodium alkoxide being generated, potassium alcoholate are bulky grains
Shape solid it is achieved that from existing powdery product to the leap of granulated product, thus solve long-standing problem people's simultaneously
Problem of solvent residual and use security hidden trouble.
The method of the present invention adopts microwave heating, and microwave one side can accelerate reaction from physical layer, accelerates water
Escape velocity, microwave another aspect chemically aspect can also decompose the complex that alcohol is formed with sodium alkoxide, potassium alcoholate, interrupts alcohol and alcohol
Between sodium, potassium alcoholate formed complex coordination key so that alcohol and solvent can fast eliminating, and formed granular product mistake
Just can remove in journey, carry out pulverizing removing without by the crude product being enclosed with alcohol and solvent, changing heat transfer type makes to do
Dry process residual solvent is difficult to the present situation of convenient in rapid escape, thus generating low-residual graininess sodium alkoxide, potassium alcoholate, improves product matter
Amount, reduce sodium alkoxide, potassium alcoholate use during security risk, technical process is simple, is very easy to industrially be widely popularized,
There is easy to operate, environmental friendliness, production safety, the feature of low energy consumption, it will promote sodium alkoxide, potassium alcoholate industry to occur revolutionary
Progressive.
Brief description
Fig. 1 is the pattern comparison diagram of the method using embodiment 1 and the Feldalat NM using produced in conventional processes.
Below in conjunction with drawings and Examples, the particular content of the present invention is described in more detail.
Specific embodiment
Defer to technique scheme, the specific embodiment of the present invention given below, it should be noted that the present invention not office
It is limited to specific examples below, all equivalents done on the basis of technical scheme each fall within the protection model of the present invention
Enclose.With reference to embodiment, the present invention is described in further details.
Embodiment 1：The preparation of low-residual graininess Feldalat NM
The present embodiment provides a kind of preparation method of low-residual graininess Feldalat NM, and the method comprises the following steps：Give
1000ml is with microwave heating, add 600ml absolute methanol in the four-hole boiling flask that can divide crystal evaporate tower, thermometer, agitator
(14.85mol), 80.0 grams of sodium hydroxide (2mol), methanol, not only as reaction raw materials but also as solvent, heats rectification and separates
Water, the frequency of microwave heating is 2450 ± 50MHz, and reaction temperature controls at 85 DEG C, evaporates head and samples to water content less than 0.01%,
Changeing back stream is to steam excessive methanol, then steams residual methanol (vacuum 100mmHg) under vacuo, obtains granular solids
Product, is characterized to this product with infrared spectrometer, and it is as follows that its infrared signature absorbs data：IR：2954；2830；1645；
1557；1486；1455；1367；890；772, consistent with Feldalat NM standard diagram.The residual measuring alcohol by gas chromatography is low
In 0.005%, particle diameter is more than 20 purposes and is more than 95%.
Accompanying drawing 1 is the pattern comparison diagram of the method using embodiment 1 and the Feldalat NM using produced in conventional processes.From in figure
It can be seen that the Feldalat NM that traditional preparation method is prepared is amorphous powder, and use the Feldalat NM of this patent technique productions
It is uniform granular product.
Embodiment 2：The preparation of low-residual graininess Feldalat NM
The present embodiment provides a kind of preparation method of low-residual graininess Feldalat NM, and the method comprises the following steps：Give
1000ml is with addition 400ml absolute methanol in microwave heating, reflux condenser, water knockout drum, thermometer, the four-hole boiling flask of agitator
(9.9mol), 80.0 grams of sodium hydroxide (2mol), 200ml benzene, is heated to reflux carrying water point water, the frequency of microwave heating is 2450
± 50MHz, reaction temperature controls at 85 DEG C, to no significantly water out, change back stream for distillation, slowly steam excessive first
Alcohol, then steam benzene, then steam remaining benzene (vacuum 100mmHg) under vacuo, obtain granular solid product, table is carried out to product
Levy, result is same as Example 1, that is, products obtained therefrom is Feldalat NM.The residual that detection obtains alcohol and solvent is less than 0.01%, particle diameter
It is more than 95% more than 15 purposes.
Embodiment 3：The preparation of low-residual graininess Feldalat KM
The present embodiment provides a kind of preparation method of low-residual graininess Feldalat KM, and the method comprises the following steps：Give
1000ml is with addition 400ml absolute methanol in microwave heating, reflux condenser, water knockout drum, thermometer, the four-hole boiling flask of agitator
(9.9mol), 112.0 grams of potassium hydroxide (2mol), 200ml benzene, is heated to reflux carrying water point water, the frequency of microwave heating is
2450 ± 50MHz, reaction temperature controls at 85 DEG C, to no significantly water out, change back stream for distillation, slowly steam excess
Methanol, then steam benzene, then steam remaining benzene (vacuum 50mmHg) under vacuo, obtain granular solid product, use infrared light
Spectrometer characterizes to this product, and it is as follows that its infrared signature absorbs data：IR：1672；1606；1444；1375；1313；1001；
887；831；707, consistent with Feldalat KM standard diagram.Alcohol is measured by gas chromatography and the residual of petroleum ether is less than
0.005%, particle diameter is more than 20 purposes and is more than 95%.
Embodiment 4：The preparation of low-residual graininess Sodium ethylate
The present embodiment provides a kind of preparation method of low-residual graininess Sodium ethylate, and the method comprises the following steps：Give
1000ml is with addition 400ml dehydrated alcohol in microwave heating, reflux condenser, water knockout drum, thermometer, the four-hole boiling flask of agitator
(6.85mol), 80.0 grams of sodium hydroxide (2mol), 200ml benzene, is heated to reflux carrying water point water, the frequency of microwave heating is
2450 ± 50MHz, reaction temperature controls at 90 DEG C, to no significantly water out, change back stream for distillation, slowly steam excess
Ethanol, then steam benzene, then steam remaining benzene (vacuum 50mmHg) under vacuo, obtain granular solid product Sodium ethylate.Inspection
The residual recording alcohol and solvent is less than 0.01%, and particle diameter is more than 20 purposes and is more than 95%.
Embodiment 5：The preparation of low-residual graininess sodium isopropylate
The present embodiment provides a kind of preparation method of low-residual graininess sodium isopropylate, and the method comprises the following steps：Give
1000ml is with addition 400ml isopropanol in microwave heating, reflux condenser, water knockout drum, thermometer, the four-hole boiling flask of agitator
(5.23mol), 80.0 grams of sodium hydroxide (2mol), 200ml toluene, is heated to reflux carrying water point water, the frequency of microwave heating is
2450 ± 50MHz, reaction temperature controls at 115 DEG C, to no significantly water out, change back stream for distillation, slowly steamed
The isopropanol of amount, then steam toluene, then steam residual toluene (vacuum 50mmgH) under vacuo, obtain granular solids isopropanol
Sodium, alcohol and solvent residual is less than 0.01%, and particle diameter is more than 20 purposes and is more than 96%.
Embodiment 6：The preparation of low-residual graininess 2- sodium butoxide
The present embodiment provides a kind of preparation method of low-residual graininess 2- sodium butoxide, and the method comprises the following steps：Give
1000ml is with microwave heating, add the 2- butanol of 600ml in the four-hole boiling flask that can divide crystal evaporate tower, thermometer, agitator
(6.56mol), 80.0 grams of sodium hydroxide (2mol), heat rectifying and dewatering, the frequency of microwave heating is 2450 ± 50MHz, reaction
Temperature control, at 135 DEG C, is less than 0.01% to evaporating head sampling water content, changeing back stream is to steam excessive 2- butanol, then
Steam remaining 2- butanol (vacuum 50mmgH) under vacuum, obtain granular solids 2- sodium butoxide, dissolvent residual is less than 0.01%, grain
Footpath is more than 20 purposes and is more than 96%.
Embodiment 7：The preparation of low-residual graininess butanol potassium
The present embodiment provides a kind of preparation method of low-residual graininess butanol potassium, and the method comprises the following steps：Give
The butanol with adding 600ml in microwave heating, reflux condenser, water knockout drum, thermometer, the four-hole boiling flask of agitator for the 1000ml
(6.56mol), 112.0 grams of potassium hydroxide (2mol), 200ml hexamethylene, is heated to reflux carrying water, the frequency of microwave heating is 2450
± 50MHz, reaction temperature controls at 90 DEG C, to no significantly water out, change back stream for distillation, slowly steam excessive ring
Hexane, then steam butanol, then steam remaining butanol (vacuum 100mmHg) under vacuo, obtains granular solids butanol potassium, alcohol and
Dissolvent residual is less than 0.01%, and particle diameter is more than 20 purposes and is more than 96%.
Embodiment 8：The preparation of low-residual graininess sodium tert-butoxide
The present embodiment provides a kind of preparation method of low-residual graininess sodium tert-butoxide, and the method comprises the following steps：Give
The anhydrous tertiary butanol with adding 600ml in microwave heating, condenser, receptor, thermometer, the four-hole boiling flask of agitator for the 1000ml
(6.27mol), 108.0 grams of Feldalat NMs (2mol), 200ml toluene, the frequency of microwave heating is 2450 ± 50MHz, is heated to 85
DEG C, side border ring steams methanol, then steams the excessive tert-butyl alcohol, then steams toluene, then steams residual toluene (vacuum under vacuo
Degree 50mmHg), obtain granular solids sodium tert-butoxide, alcohol and solvent residual is less than 0.01%, and particle diameter is more than 20 purposes and is more than 96%.
Embodiment 9：The preparation of low-residual graininess potassium tert-butoxide
The present embodiment provides a kind of preparation method of low-residual graininess sodium tert-butoxide, and the method comprises the following steps：Give
1000ml is with the addition anhydrous tertiary fourth of 600ml in microwave heating, reflux condenser, receptor, thermometer, the four-hole boiling flask of agitator
Alcohol (6.27mol), 140.0 grams of Feldalat KMs (2mol), 200ml toluene, the frequency of microwave heating is 2450 ± 50MHz, is heated to
85 DEG C, side border ring steams methanol, then steams the excessive tert-butyl alcohol, then steams toluene, then it is (true to steam residual toluene under vacuo
Reciprocal of duty cycle 50mmHg), obtain granular solids sodium tert-butoxide, alcohol and solvent residual is less than 0.01%, and particle diameter is more than more than 20 purposes
96%.
Alkali Feldalat KM in the present embodiment can be replaced with potassium ethoxide.
Embodiment 10：The preparation of low-residual graininess normal propyl alcohol sodium
The present embodiment provides a kind of preparation method of low-residual graininess normal propyl alcohol sodium, and the method comprises the following steps：Give
1000ml is with the addition anhydrous normal propyl alcohol of 600ml in microwave heating, condenser, receptor, thermometer, the four-hole boiling flask of agitator
(7.84mol), 78.0 grams of Sodamide .s (2mol), 200ml toluene, the frequency of microwave heating is 2450 ± 50MHz, is heated to 60
DEG C, draw the ammonia that reaction produces, then heat up and steam excessive normal propyl alcohol, then steam toluene, then steam remaining first under vacuo
Benzene (vacuum 50mmHg), obtains granular solids normal propyl alcohol sodium, and alcohol and solvent residual is less than 0.01%, and it is big that particle diameter is more than 20 purposes
In 96%.
Alkali Sodamide. in the present embodiment can be replaced by potassamide, prepares low-residual graininess normal propyl alcohol potassium.
Embodiment 11：The preparation of low-residual granular sodium tert-pentoxide
The present embodiment provides a kind of preparation method of low-residual granular sodium tert-pentoxide, and the method comprises the following steps：Give
1000ml is with addition 600ml tert-pentyl alcohol in microwave heating, condenser, receptor, thermometer, the four-hole boiling flask of agitator
(5.51mol), 78.0 grams of Sodamide .s (2mol), 200ml dimethylbenzene, the frequency of microwave heating is 2450 ± 50MHz, is heated to 50
DEG C, draw the ammonia that reaction produces, then heat up and steam excessive tert-pentyl alcohol, then steam dimethylbenzene, then steam remnants under vacuo
Dimethylbenzene (vacuum 50mmHg), obtains granular solids sodium tert-amyl alcohol, and alcohol and solvent residual is less than 0.01%, and particle diameter is more than 20 mesh
More than 96%.
Embodiment 12：The preparation of low-residual graininess sodium tert-butoxide
The present embodiment provides a kind of preparation method of low-residual graininess sodium tert-butoxide, and the method comprises the following steps：Give
1000ml is with addition 200ml anhydrous tertiary butanol in microwave heating, condenser, water knockout drum, thermometer, the four-hole boiling flask of agitator
(2.09mol), 78.0 grams of Sodamide .s (2mol), 200ml1,4- dioxane, the frequency of microwave heating is 2450 ± 50MHz, plus
Heat, to 60 DEG C, is drawn the ammonia that reaction produces, then is heated up and steam the excessive tert-butyl alcohol, then steam Isosorbide-5-Nitrae-dioxane, then true
Steam remaining Isosorbide-5-Nitrae-dioxane (vacuum 50mmHg) under sky, obtain granular solids sodium tert-butoxide, alcohol and solvent residual is less than
0.01%, particle diameter is more than 20 purposes and is more than 96%.
Embodiment 13：The preparation of low-residual graininess Feldalat NM
The present embodiment provides a kind of preparation method of low-residual graininess Feldalat NM, and the method comprises the following steps：Give
1000ml is with addition 85ml absolute methanol in microwave heating, condenser, receptor, thermometer, the four-hole boiling flask of agitator
(2.1mol), 78.0 grams of Sodamide .s (2mol), 200ml1,3- dioxolane, the frequency of microwave heating is 2450 ± 50MHz, plus
Heat, to 60 DEG C, is drawn the ammonia that reaction produces, then is heated up and steam excessive methanol, then steam 1,3- dioxolane, then in vacuum
Under steam remaining 1,3- dioxolane (vacuum 50mmHg), obtain granular solids Feldalat NM, alcohol and solvent residual is less than
0.01%, particle diameter is more than 20 purposes and is more than 96%.
Embodiment 14：The preparation of low-residual graininess hexamethylene sodium alkoxide
The present embodiment provides a kind of preparation method of low-residual graininess hexamethylene sodium alkoxide, and the method comprises the following steps：Give
1000ml is with addition 600ml Hexalin in microwave heating, condenser, receptor, thermometer, the four-hole boiling flask of agitator
(5.77mol), 7.4 grams of Sodamide .s (0.19mol), 200ml trimethylbenzene, the frequency of microwave heating is 2450 ± 50MHz, reacts
In journey, the heating of electrically heated mode assisted microwave synthesis, is heated to 60 DEG C, draws the ammonia that reaction produces, then heats up and steam excessive ring
Hexanol, then steam remaining trimethylbenzene (vacuum 50mmHg) under vacuo, when removing under vacuum, only with microwave action, do not adopt
Use electrical heating.Obtain granular solids hexamethylene sodium alkoxide, alcohol and solvent residual is less than 0.01%, and particle diameter is more than 20 purposes and is more than 96%.
The solvent of the application is not limited to the solvent in above-described embodiment, in view of length, simply show one in embodiment
A little specific examples, the solvent employed in the application at least includes following kind of solvent：Reaction raw materials alcohol itself or compare alcohol
The high varsol of boiling point, aromatic hydrocarbon solvent, organic Ammonia solvent or ether solvent.Described varsol be linear paraffin,
Branched paraffin, cyclic alkane or unsaturated olefin；Described aromatic hydrocarbon solvent be benzene,toluene,xylene, trimethylbenzene, ethylbenzene, two
Ethylbenzene or isopropylbenzene；Described organic Ammonia solvent is primary amine, secondary amine, tertiary amine, ring-type secondary amine or cyclic tertiary amine；
Described ether solvent is fatty alcohol ether, fragrant alcohol ether, cyclic ethers or dioxy cyclic ethers.
Claims (8)
1. a kind of graininess sodium alkoxide or potassium alcoholate preparation method it is characterised in that：The method is corresponding with the corresponding alkali of sodium or potassium
Alkali is raw material with alcohol, mixes with solvent, is reacted by the way of microwave heating, and reaction removes after terminating under microwave action
React remaining alcohol and solvent, obtain graininess sodium alkoxide, potassium alcoholate；
Described microwave frequency is 2450 ± 50MHz；
The corresponding alkali of described sodium or the corresponding alkali of potassium are 1 with the mol ratio of alcohol：(1.05～30).
2. the method for claim 1 it is characterised in that：The corresponding alkali of described sodium is sodium hydroxide, Sodamide., methanol
Sodium or Sodium ethylate；The corresponding alkali of described potassium is potassium hydroxide, potassamide, Feldalat KM or potassium ethoxide.
3. the method for claim 1 it is characterised in that：Described alcohol is the alcohol of the alcohol, the alcohol of side chain or ring-type of straight chain.
4. method as claimed in claim 3 it is characterised in that：The alcohol of described straight chain is methanol, ethanol, propanol or butanol；
The alcohol of described side chain is isopropanol, 2- butanol, the tert-butyl alcohol or tert-pentyl alcohol；The alcohol of described ring-type is Hexalin.
5. the method for claim 1 it is characterised in that：Described solvent is reaction raw materials alcohol itself or higher than alcohol boiling point
Varsol, aromatic hydrocarbon solvent, organic Ammonia solvent or ether solvent.
6. method as claimed in claim 5 it is characterised in that：Described varsol is linear paraffin, branched paraffin, ring-type
Alkane or unsaturated olefin；Described aromatic hydrocarbon solvent is benzene,toluene,xylene, trimethylbenzene, ethylbenzene, diethylbenzene or isopropylbenzene；
Described organic amine solvent is primary amine, secondary amine or tertiary amine；Described ether solvent is fatty alcohol ether or fragrant alcohol ether.
7. the method for claim 1 it is characterised in that：The described process reacted by the way of microwave heating
In can also using other mode of heatings carry out auxiliary heating.
8. the method for claim 1 it is characterised in that：Described reaction temperature and the temperature control of removing alcohol and solvent
At 50 DEG C～150 DEG C；The Stress control of described removing alcohol and solvent is in -0.5mmHg～normal pressure.
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| CN106542967A (en) * | 2016-11-02 | 2017-03-29 | 宁夏佰斯特医药化工有限公司 | A kind of solid sodium methylate preparation method |
| CN110041225A (en) * | 2019-04-30 | 2019-07-23 | 湖州柏特生物科技有限公司 | A kind of production method of biacetyl monoxime sodium, sylvite |
| CN112920019A (en) * | 2021-01-25 | 2021-06-08 | 安徽金邦医药化工有限公司 | Novel process for preparing high-purity sodium tert-butoxide |
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