CN105169240A - Traditional Chinese medicine composition for treating stagnation of blood stasis and vascular blockage and preparation method of traditional Chinese medicine composition - Google Patents

Abstract

The invention discloses a traditional Chinese medicine composition for treating stagnation of blood stasis and vascular blockage and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared by processing radix salviae miltiorrhizae, caulis spatholobi, radix curcumae, olibanum and myrrh according to certain ratio. Compared with the prior art, the preparation method has the advantages of advanced technology and obvious curative effect; the traditional Chinese medicine composition is used for treating vasculitis, scleroderma and arteriosclerotic lower extremity vessel occlusion caused by stagnation of blood stasis and vascular blockage, and has a remarkable therapeutical effect for coronary heart disease and cerebral thrombosis sequelae. The traditional Chinese medicine composition and the preparation method have the advantages of reasonable formula, advanced technology and significant curative effect, and no toxic or side effect.

Description

A kind of Chinese medicine composition obstructed for stagnation of blood stasis, vascular and preparation method thereof

Technical field

The present invention relates to a kind of Chinese medicine composition obstructed for stagnation of blood stasis, vascular and preparation method thereof, be characterized in can be used in treatment vasculitis, scleroderma, arteriosclerosis lower extremities vascular occlusion disease, and coronary heart disease, cerebral infarction sequela are also had significant therapeutic effect, belongs to pharmaceutical technology sectors.

Technical background

Vasculitis is surgical common disease, frequently-occurring disease.Disease sees that suffering from toe (finger) likes warm being afraid of cold, palor is sent out cool, numb pain, meets cold severe pain, has intermittent claudication or persistence stationarity pain, its limb color can be dark red by pale turn, more obvious time sagging, raise, see pale, gait is walked lamely, can accompany shank foot that migratory erythema, tuberosity or hard rope occur repeatedly, the purple black withered necrosis of severe one acra.Vasculitis can betide artery and vein blood vessel.Person is referred to as thromboangiitis obliterans to betide tremulous pulse, and what betide vein is called dvt.Artery and vein all can occur, but is common in veins of lower extremity.Due to clinical diagnosis and treatment comparatively difficulty, therefore with the passing of time the course of disease usually delays, and patient suffering can't bear, and has a strong impact on the healthy of people.

Prior art: Chinese patent publication disclosed the name of being declared by the applicant and was called " a kind of for congestion retardance, the obstructed Chinese medicine preparation of vascular and preparation method thereof " on January 14th, 2009, publication number is the patent application of CN101342356A, and the preparation method of inventing described Chinese medicine preparation is mainly: Radix Salviae Miltiorrhizae, Caulis Spatholobi decoct with water three times.Inventor is through finding the Study on Preparation of this patent for a long time: Radix Salviae Miltiorrhizae, Caulis Spatholobi decoct with water and extract obtained preparation curative effect is not very desirable; Inventor, through concentrating on studies for many years, finds " Radix Salviae Miltiorrhizae, Caulis Spatholobi decoct with water three times " make into " Radix Salviae Miltiorrhizae, Caulis Spatholobi add 50% alcohol reflux three times " obtained afterwards preparation, the raising of its pharmacodynamic experiment Be very effective.

Summary of the invention

The object of the invention is to for the defect existing for state of the art, by excavating the abundant Chinese medicine resource of motherland, in conjunction with a large amount of pharmacodynamic experiment Effect disquisition, provide a kind of curative effect more remarkable, a kind of Chinese medicine composition obstructed for stagnation of blood stasis, vascular and preparation method thereof.

For achieving the above object, the technical solution used in the present invention is:

1, Chinese medicine composition of the present invention and preparation method:

Formula consists of: Radix Salviae Miltiorrhizae 526.24g Caulis Spatholobi 526.24g Radix Curcumae 84.2g Olibanum 84.2g Myrrha 84.2g;

Preparation method is: the above five tastes, and Olibanum, Myrrha, turmeric powder are broken into fine powder, crosses 100 eye mesh screens, for subsequent use; Radix Salviae Miltiorrhizae, Caulis Spatholobi add 50% alcohol reflux three times, and 1.5 hours first times, second and third time each 1 hour, alcohol adding amount is respectively inventory 10,8,6 times, merge three extracting solution, filter, when filtrate recycling ethanol is concentrated into 60 DEG C, record the extractum that relative density is 1.24 ~ 1.28, add Olibanum, Myrrha, Radix Curcumae fine powder, mixing, dry, pulverize under the condition of≤60 DEG C, add each dosage form proper auxiliary materials, make capsule, tablet or granule.

2, the preparation of Chinese medicinal composition capsules agent of the present invention:

Formula consists of: Radix Salviae Miltiorrhizae 526.24g Caulis Spatholobi 526.24g Radix Curcumae 84.2g Olibanum 84.2g Myrrha 84.2g;

Preparation method is: the above five tastes, and Olibanum, Myrrha, turmeric powder are broken into fine powder, crosses 100 eye mesh screens, for subsequent use; Radix Salviae Miltiorrhizae, Caulis Spatholobi add 50% alcohol reflux three times, and 1.5 hours first times, second and third time each 1 hour, alcohol adding amount is respectively inventory 10,8,6 times, merges three extracting solution, filters, filtrate recycling ethanol records the extractum that relative density is 1.24 ~ 1.28 when being concentrated into 60 DEG C, add Olibanum, Myrrha, Radix Curcumae fine powder, mixing, dry, pulverize under the condition of≤60 DEG C, it is appropriate to add starch, mixing, granulates, dry, encapsulated, make 1000, obtain capsule.

3, the preparation of Chinese medicine composition tablet of the present invention:

Formula consists of: Radix Salviae Miltiorrhizae 526.24g Caulis Spatholobi 526.24g Radix Curcumae 84.2g Olibanum 84.2g Myrrha 84.2g;

Preparation method is: the above five tastes, and Olibanum, Myrrha, turmeric powder are broken into fine powder, crosses 100 eye mesh screens, for subsequent use; Radix Salviae Miltiorrhizae, Caulis Spatholobi add 50% alcohol reflux three times, 1.5 hours first times, second and third time each 1 hour, and alcohol adding amount is respectively inventory 10,8,6 times, merges three extracting solution, filter, filtrate recycling ethanol records the extractum that relative density is 1.24 ~ 1.28 when being concentrated into 60 DEG C, add Olibanum, Myrrha, Radix Curcumae fine powder, mixing, dry under the condition of≤60 DEG C, pulverize, add appropriate amount of starch, mixing, granulate, drying, adds appropriate magnesium stearate, tabletting, make 1000, obtain tablet.

4, the preparation of Chinese medicinal composition granules of the present invention:

Formula consists of: Radix Salviae Miltiorrhizae 526.24g Caulis Spatholobi 526.24g Radix Curcumae 84.2g Olibanum 84.2g Myrrha 84.2g;

Preparation method is: the above five tastes, and Olibanum, Myrrha, turmeric powder are broken into fine powder, crosses 100 eye mesh screens, for subsequent use; Radix Salviae Miltiorrhizae, Caulis Spatholobi add 50% alcohol reflux three times, and 1.5 hours first times, second and third time each 1 hour, alcohol adding amount is respectively inventory 10,8,6 times, merges three extracting solution, filters, filtrate recycling ethanol records the extractum that relative density is 1.24 ~ 1.28 when being concentrated into 60 DEG C, add Olibanum, Myrrha, Radix Curcumae fine powder, mixing, dry, pulverize under the condition of≤60 DEG C, add appropriate dextrin, mixing, granulates, dry, make 1000g granule, pack, obtains granule.

Pharmacodynamics is tested

Experiment purpose: by the pharmacological experiment study such as antiinflammatory, analgesia, platelet aggregation rate, antithrombotic to vascular recovery capsule of the present invention and former invention capsule, vascular recovery capsule of the present invention and former invention capsule are carried out contrast experiment, observes the power of its pharmacological action.

Test method: on the impact of vascular recovery capsule of the present invention and former invention capsule xylol induced mice auricle edema; On Carrageenan causes the impact of mice foot swelling; The impact of Dichlorodiphenyl Acetate induced mice writhing response; On the impact of rat's blood stasis model platelet aggregation rate; On the thrombotic impact of rat vein.

Test medicine:

1, former invention capsule preparation: be CN101342356A according to publication number disclosed on January 14th, 2009 Chinese patent publication, embodiment 1 method that name is called " a kind of Chinese medicine preparation obstructed for congestion retardance, vascular and preparation method thereof " obtains.

2, vascular recovery capsule preparation of the present invention: the method for license description embodiment 1 of the present invention obtains.

One, the impact of xylol induced mice auricle edema

Experiment material

1, animal: Kunming mouse, male and female have concurrently, body weight 18 ~ 22g.

2, medicine: former invention Capsules group; Large, medium and small three the dosage groups of vascular recovery capsule of the present invention.Medicine configures with normal saline on pretreatment, gastric infusion.

Experimental technique

Kunming mouse 50, male and female half and half, body weight 18 ~ 22g, is divided into 5 groups at random, often organizes 10.The normal saline of matched group gavage same volume; Vascular recovery capsule group of the present invention respectively gastric infusion 1.2,2.4,4.8g crude drug/kg; Former invention Capsules group gastric infusion 4.8g crude drug/kg.Successive administration 7d, after last administration 1h, is only applied to two sides inside and outside auris dextra with 100% dimethylbenzene 0.2ml/, left ear does not do any process, put to death by animal etherization after 2h, subtract lower ears 5mm diameter card punch and lay round auricle at the same position of mice respectively, electronic analytical balance is weighed.Swelling index (mice ear degree=auris dextra sheet weight-left auricle weight) using mice ear degree as dimethylbenzene induced Acute inflammation.Experimental result: in table 1

Table 1 is on the impact of swelling caused by Mice Auricle dimethylbenzene

Compared with matched group: * * P < 0.01; #P < 0.05 compared with former invention Capsules group

Result shows: control group mice auris dextra is obviously red and swollen, and thickness increases, and auricle swelling degree is large.Vascular recovery capsule group of the present invention and former invention Capsules group xylol induced mice auricle edema have significant inhibitory action, have pole significant difference (P < 0.01) compared with matched group; Vascular recovery capsule heavy dose group of the present invention has significant difference (P < 0.05) compared with former invention Capsules group; Visible, vascular recovery capsule of the present invention is stronger than the antiinflammatory action of former invention capsule.

Two, on Carrageenan causes the impact of mice foot swelling

Experiment material

1, animal: Kunming mouse, male and female have concurrently, body weight 18 ~ 22g.

2, medicine: former invention Capsules group; Large, medium and small three the dosage groups of vascular recovery capsule of the present invention.Medicine configures with normal saline on pretreatment, gastric infusion.

Experimental technique

Kunming mouse 50, male and female half and half, body weight 18 ~ 22g, is divided into 5 groups at random, often organizes 10.The normal saline of matched group gavage same volume; Vascular recovery capsule group of the present invention respectively gastric infusion 1.2,2.4,4.8g crude drug/kg; Former invention Capsules group gastric infusion 4.8g crude drug/kg.Successive administration 7d, every day 1 time, before last administration, 2h is by every the mice left back foot foot sole of the foot 1% carrageenin 0.03mL.After medicine, animal is put to death in 1h dislocation of cervical vertebra, cuts metapedes and weighs respectively, with the difference of two heavy sensation in the foot amounts for swelling from ankle joint 0.5mm place.Experimental result: in table 2

Table 2 on Carrageenan causes the impact of mice foot swelling

Compared with matched group: * * P < 0.01; #P < 0.05 compared with former invention Capsules group

Result shows: vascular recovery capsule group of the present invention and former invention Capsules group can obviously suppress carrageenin to cause the swelling of mice foot, has pole significant difference (P < 0.01) compared with matched group; Vascular recovery capsule heavy dose group of the present invention has significant difference (P < 0.05) compared with former invention Capsules group.Visible, vascular recovery capsule of the present invention is stronger than former invention capsule antiinflammatory action.

Three, the impact of Dichlorodiphenyl Acetate induced mice writhing response

Experiment material

1, animal: Kunming mouse, male and female have concurrently, body weight 18 ~ 22g.

2, medicine: former invention Capsules group; Large, medium and small three the dosage groups of vascular recovery capsule of the present invention.Medicine configures with normal saline on pretreatment, gastric infusion.

Experimental technique

Kunming mice 50, male and female half and half, body weight 18 ~ 22g, is divided into 5 groups at random, often organizes 10.The normal saline of matched group gavage same volume; Vascular recovery capsule group of the present invention respectively gastric infusion 1.2,2.4,4.8g crude drug/kg; Former invention Capsules group gastric infusion 4.8g crude drug/kg.Successive administration 7d, every day 1 time, after last administration 1h, every Mus equal lumbar injection 0.6% acetic acid 0.2ml/ only, records mouse writhing number of times in 15min, and calculates each group of analgesia percentage rate.Experimental result: in table 3

The impact of table 3 Dichlorodiphenyl Acetate induced mice writhing response

Compared with matched group: * * P < 0.01; #P < 0.05 compared with former invention Capsules group

Result shows: vascular recovery capsule group of the present invention and former invention Capsules group Dichlorodiphenyl Acetate induced mice writhing have obvious inhibitory action, there is good dose-effect relationship, along with the increasing of dosage, writhing number of times reduces, and has the difference (P < 0.01) of pole significance compared with matched group; Vascular recovery capsule heavy dose group of the present invention has significant difference (P < 0.05) compared with former invention Capsules group.Visible, vascular recovery capsule of the present invention is stronger than the analgesic activity of former invention capsule.

Four, on the impact of rat's blood stasis model platelet aggregation rate

Experiment material

1, animal: SD rat, male and female have concurrently, body weight 180 ~ 220g.

2, medicine: former invention Capsules group; Large, medium and small three the dosage groups of vascular recovery capsule of the present invention.Medicine configures with normal saline on pretreatment, gastric infusion.

Experimental technique

SD rat 50, male and female half and half, body weight 180 ~ 220g, is divided into 5 groups at random, often organizes 10, the normal saline of matched group gavage same volume; Vascular recovery capsule group of the present invention respectively gastric infusion 0.6,1.2,2.4g crude drug/kg; Former invention Capsules group gastric infusion 2.4g crude drug/kg.Successive administration 7d, every day 1 time, 1h after last administration, each group rat skin lower injection 0.1% adrenalin hydrochloride 0.09ml/kg, totally 2 times, interval 4h, rat is immersed 5min in frozen water by period, causes acute blood-stasis model.After disposing, all Rat Fast can't help water, morning next day, abdominal aortic blood, 3.8% sodium citrate anticoagulant, the centrifugal 6min of 800r/min, gets supernatant and namely obtains platelet rich plasma (PRP), the centrifugal 10min of remainder 3000r/min, get supernatant and namely obtain platelet poor plasma (PPP), adjust platelet count in PRP to be about 3 × 1011/L with PPP.Get PRP400 μ L, after 37 DEG C of incubation 2min, add derivant ADP solution 10 μ L (final concentration 10 μm of ol/L), the maximum platelet aggregation rate of inducing by Born turbidimetry for Determination ADP.Experimental result: in table 4

Table 4 is on the impact of rat's blood stasis model platelet aggregation rate

Compared with matched group: * * P < 0.01; #P < 0.05 compared with former invention Capsules group

Result shows: vascular recovery capsule group of the present invention and former invention Capsules group significantly reduce the hematoblastic aggregation rate of rat's blood stasis model, has pole significant difference (P < 0.01) compared with matched group; Vascular recovery capsule heavy dose group of the present invention has significant difference (P < 0.05) compared with former invention Capsules group.Visible, the effect that vascular recovery capsule of the present invention reduces platelet aggregation rate than former invention capsule is strong.

Five, on the thrombotic impact of rat vein

Experiment material

1, animal: SD rat, male and female have concurrently, body weight 180 ~ 220g.

2, medicine: former invention Capsules group; Large, medium and small three the dosage groups of vascular recovery capsule of the present invention.Medicine configures with normal saline on pretreatment, gastric infusion.

Experimental technique

SD rat 50, male and female half and half, body weight 180 ~ 220g, is divided into 5 groups at random, often organizes 10, the normal saline of matched group gavage same volume; Vascular recovery capsule group of the present invention respectively gastric infusion 0.6,1.2,2.4g crude drug/kg; Former invention Capsules group gastric infusion 2.4g crude drug/kg.Successive administration 7d, after last administration 1h, 2% pentobarbital sodium lumbar injection (50mg/kg) anesthesia, dorsal position is fixed, and cuts stomach wall open, is separated postcava, in left renal vein and postcava infall ligation postcava, then suturing them.Reopen abdominal cavity after 4h, below ligation, 2cm place folder closes blood vessel, cuts tube chamber open, and take out embolus, claim weight in wet base with micro-electronic balance after sucking residual blood with filter paper, then put in an oven by embolus, 70 DEG C of oven dry, claim dry weight after 2h.

Experimental result: in table 5

Table 5 is on the thrombotic impact of rat vein

Compared with matched group: * * P < 0.01; #P < 0.05 compared with former invention Capsules group

Result shows: vascular recovery capsule group of the present invention and former invention Capsules group obviously suppress the formation of rat vein thrombosis, has pole significant difference (P < 0.01) compared with matched group; Vascular recovery capsule heavy dose group of the present invention has significant difference (P < 0.05) compared with former invention Capsules group.Visible, vascular recovery capsule of the present invention is stronger than the inhibitory action of former invention Capsule in Rats venous thrombosis.

Experimental result: vascular recovery capsule group of the present invention and former invention Capsules group can obviously suppress dimethylbenzene induced mice auricle edema and carrageenin to cause the swelling of mice foot; Dichlorodiphenyl Acetate induced mice writhing has obvious inhibitory action; The hematoblastic aggregation rate of obvious reduction rat's blood stasis model; The formation of obvious suppression rat vein thrombosis.

Conclusion: vascular recovery capsule of the present invention is stronger than the pharmacological action such as antiinflammatory, analgesia, platelet aggregation rate, antithrombotic of former invention capsule, therefore, vascular recovery capsule of the present invention than former invention capsule be used for stagnation of blood stasis, vascular obstructed cause vasculitis, scleroderma, arteriosclerosis lower extremities vascular occlusion disease clinical efficacy good.

The specific embodiment of the invention:

Embodiment 1:

Formula forms: Radix Salviae Miltiorrhizae 526.24g Caulis Spatholobi 526.24g Radix Curcumae 84.2g Olibanum 84.2g Myrrha 84.2g;

Preparation method is: the above five tastes, and Olibanum, Myrrha, turmeric powder are broken into fine powder, crosses 100 eye mesh screens, for subsequent use; Radix Salviae Miltiorrhizae, Caulis Spatholobi add 50% alcohol reflux three times, and 1.5 hours first times, second and third time each 1 hour, alcohol adding amount is respectively inventory 10,8,6 times, merges three extracting solution, filters, filtrate recycling ethanol records the extractum that relative density is 1.24 ~ 1.28 when being concentrated into 60 DEG C, add Olibanum, Myrrha, Radix Curcumae fine powder, mixing, dry, pulverize under the condition of≤60 DEG C, it is appropriate to add starch, mixing, granulates, dry, encapsulated, make 1000, obtain capsule.

Embodiment 2:

Formula consists of: Radix Salviae Miltiorrhizae 526.24g Caulis Spatholobi 526.24g Radix Curcumae 84.2g Olibanum 84.2g Myrrha 84.2g;

Preparation method is: the above five tastes, and Olibanum, Myrrha, turmeric powder are broken into fine powder, crosses 100 eye mesh screens, for subsequent use; Radix Salviae Miltiorrhizae, Caulis Spatholobi add 50% alcohol reflux three times, 1.5 hours first times, second and third time each 1 hour, and alcohol adding amount is respectively inventory 10,8,6 times, merges three extracting solution, filter, filtrate recycling ethanol records the extractum that relative density is 1.24 ~ 1.28 when being concentrated into 60 DEG C, add Olibanum, Myrrha, Radix Curcumae fine powder, mixing, dry under the condition of≤60 DEG C, pulverize, add appropriate amount of starch, mixing, granulate, drying, adds appropriate magnesium stearate, tabletting, make 1000, obtain tablet.

Embodiment 3:

Formula consists of: Radix Salviae Miltiorrhizae 526.24g Caulis Spatholobi 526.24g Radix Curcumae 84.2g Olibanum 84.2g Myrrha 84.2g;

Preparation method is: the above five tastes, and Olibanum, Myrrha, turmeric powder are broken into fine powder, crosses 100 eye mesh screens, for subsequent use; Radix Salviae Miltiorrhizae, Caulis Spatholobi add 50% alcohol reflux three times, and 1.5 hours first times, second and third time each 1 hour, alcohol adding amount is respectively inventory 10,8,6 times, merges three extracting solution, filters, filtrate recycling ethanol records the extractum that relative density is 1.24 ~ 1.28 when being concentrated into 60 DEG C, add Olibanum, Myrrha, Radix Curcumae fine powder, mixing, dry, pulverize under the condition of≤60 DEG C, add appropriate dextrin, mixing, granulates, dry, make 1000g granule, pack, obtains granule.

Claims (4)

1., for the Chinese medicine composition that stagnation of blood stasis, vascular are obstructed, it is characterized in that the formula of described Chinese medicine composition consists of:

Radix Salviae Miltiorrhizae 526.24g Caulis Spatholobi 526.24g Radix Curcumae 84.2g Olibanum 84.2g Myrrha 84.2g;

Preparation method is: the above five tastes, and Olibanum, Myrrha, turmeric powder are broken into fine powder, crosses 100 eye mesh screens, for subsequent use; Radix Salviae Miltiorrhizae, Caulis Spatholobi add 50% alcohol reflux three times, and 1.5 hours first times, second and third time each 1 hour, alcohol adding amount is respectively inventory 10,8,6 times, merge three extracting solution, filter, when filtrate recycling ethanol is concentrated into 60 DEG C, record the extractum that relative density is 1.24 ~ 1.28, add Olibanum, Myrrha, Radix Curcumae fine powder, mixing, dry, pulverize under the condition of≤60 DEG C, add each dosage form proper auxiliary materials, make capsule, tablet or granule.

2. the preparation method of Chinese medicine composition according to claim 1, is characterized in that the formula of described Chinese medicine composition consists of:

Radix Salviae Miltiorrhizae 526.24g Caulis Spatholobi 526.24g Radix Curcumae 84.2g Olibanum 84.2g Myrrha 84.2g;

Preparation method is: the above five tastes, and Olibanum, Myrrha, turmeric powder are broken into fine powder, crosses 100 eye mesh screens, for subsequent use; Radix Salviae Miltiorrhizae, Caulis Spatholobi add 50% alcohol reflux three times, and 1.5 hours first times, second and third time each 1 hour, alcohol adding amount is respectively inventory 10,8,6 times, merges three extracting solution, filters, filtrate recycling ethanol records the extractum that relative density is 1.24 ~ 1.28 when being concentrated into 60 DEG C, add Olibanum, Myrrha, Radix Curcumae fine powder, mixing, dry, pulverize under the condition of≤60 DEG C, it is appropriate to add starch, mixing, granulates, dry, encapsulated, make 1000, obtain capsule.

3. the preparation method of Chinese medicine composition according to claim 1, is characterized in that the formula of described Chinese medicine composition consists of:

Radix Salviae Miltiorrhizae 526.24g Caulis Spatholobi 526.24g Radix Curcumae 84.2g Olibanum 84.2g Myrrha 84.2g;

Preparation method is: the above five tastes, and Olibanum, Myrrha, turmeric powder are broken into fine powder, crosses 100 eye mesh screens, for subsequent use; Radix Salviae Miltiorrhizae, Caulis Spatholobi add 50% alcohol reflux three times, 1.5 hours first times, second and third time each 1 hour, and alcohol adding amount is respectively inventory 10,8,6 times, merges three extracting solution, filter, filtrate recycling ethanol records the extractum that relative density is 1.24 ~ 1.28 when being concentrated into 60 DEG C, add Olibanum, Myrrha, Radix Curcumae fine powder, mixing, dry under the condition of≤60 DEG C, pulverize, add appropriate amount of starch, mixing, granulate, drying, adds appropriate magnesium stearate, tabletting, make 1000, obtain tablet.

4. the preparation method of Chinese medicine composition according to claim 1, is characterized in that the formula of described Chinese medicine composition consists of:

Radix Salviae Miltiorrhizae 526.24g Caulis Spatholobi 526.24g Radix Curcumae 84.2g Olibanum 84.2g Myrrha 84.2g;

Preparation method is: the above five tastes, and Olibanum, Myrrha, turmeric powder are broken into fine powder, crosses 100 eye mesh screens, for subsequent use; Radix Salviae Miltiorrhizae, Caulis Spatholobi add 50% alcohol reflux three times, and 1.5 hours first times, second and third time each 1 hour, alcohol adding amount is respectively inventory 10,8,6 times, merges three extracting solution, filters, filtrate recycling ethanol records the extractum that relative density is 1.24 ~ 1.28 when being concentrated into 60 DEG C, add Olibanum, Myrrha, Radix Curcumae fine powder, mixing, dry, pulverize under the condition of≤60 DEG C, add appropriate dextrin, mixing, granulates, dry, make 1000g granule, pack, obtains granule.