CN105168173A

CN105168173A - Fungi polysaccharide complex anticancer and cancer prevention and treatment drug

Info

Publication number: CN105168173A
Application number: CN201510337886.3A
Authority: CN
Inventors: 冯学江
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-06-10
Filing date: 2015-06-10
Publication date: 2015-12-23

Abstract

The invention relates to a fungi polysaccharide complex anticancer and cancer prevention and treatment drug. According to the present invention, 23 kinds of drugs, edible fungi fruiting body, dendrobium officinale kimura et migo and panax ginseng are subjected to air-drying or baking, the dried mixture are crushed, the crushed material is screened with a 40 mesh sieve to obtain powder, and purification is performed by using an enzymolysis water leaching technology and an ultra-filtration concentration alcohol precipitation technology to obtain the fungi polysaccharide and a small amount of glycopeptides; the fungi polysaccharide has strong cancer inhibition activity and provides effects on a variety of tumor cell lines with different specificities; in the experiments, the raw material extract of the product has been used for the cancer treatment; and the inhibition rate is 70-99.6%, and recurrence does not occur in the recovered secondary infection mouse.

Description

Fungus polysaccharide complex antitumor and prevention and curing cancer drug

The present invention pulverizes to obtain powder after 23 kinds of medicines, food fungus sporophore and two kinds of medicinal plants are dried or dried, and adopts enzymolysis flooding technology, ultra concentration precipitate with ethanol technology, the complex of the multiple fungus polysaccharide of synthesis---medicine bacterium.

Fungus medicine all has significant effect in antiviral, antitumor, treatment diabetes in recent years, as the Trametes robiniphila Murr of resistance of hepatitis B, the Inonqqus obliquus etc. of prevention and therapy diabetes, fungus medicine has unique effects in enhancing human body immunity function aspects, cell and humoral immune function can not only be strengthened, lymphocyte differentiation can also be promoted, improve the activity of cytokine, thus improve immunity of organisms.

The most important pharmacological function of fungus medicine is antitumor action, and its antineoplastic action main manifestations is: the generation of prophylaxis of tumours, the transfer of prophylaxis of tumours, stimulates the formation of antibody, with cancer therapy drug synergism.

The medicine bacterium of polysaccharide has scavenging free radicals, improves the activity of activities of antioxidant enzymes and anti-lipid peroxidation.

Have hypoglycemic effect, its mechanism mainly contains the following aspects: 1. stimulate islet β cell insulin; 2. protect and repair beta Cell of islet; 3. insulin releasing is promoted by the expression of Portugal's (GLUT2 albumen); 4. insulin resistant is improved; 5. hepatic glucose metabolism is accelerated; 6. the absorption to glucose is reduced.

Have blood fat reducing anti thrombotic action, its mechanism mainly contains: the absorption suppressing exogenous lipid, suppresses the synthesis of endogenous lipid, affect the distribution of blood fat, running and drain, regulating lipid metabolism.

Other effect, as radioprotective, improves immunity, antiviral, anti-inflammatory, raising memory etc.

Fungus is used as medicine of less types, correlational study weak foundation.Although China's edible and medical fungi is wide in variety, what really can formally be used as medicine is less than 50 kinds.The relative plant amedica of kind is lacked a lot, although the case that relates to of fungus medicine is relatively more extensive in addition, but has very big-difference for certain concrete case.Therefore multiple fungus polysaccharide synthetic solves this shortcoming problem.Its effect is suitable for hepatocarcinoma, pulmonary carcinoma, the esophageal carcinoma, tracheocarcinoma, nasopharyngeal carcinoma, laryngeal carcinoma, gastric cancer, breast carcinoma, carcinoma of endometrium, cervical cancer, cancer of pancreas, lymphatic cancer, rectal cancer, the cerebral tumor (brain cancer), leukemia (white cancer), colon cancer, thyroid carcinoma, bladder cancer, ehrlich ascites carcinoma, anus cancer, cancer of vagina, cloudy Siberian cocklebur cancer, meat cancer etc.The various tuberculosis, hepatitis B, acquired immune deficiency syndrome (AIDS) and the influenza that are also applicable to former or recur.Hypertension, cerebrovascular, diabetes can also be prevented and treated.The crowd of being suitable for has newfound various middle and advanced stage cancer to suffer from; With perform the operation chemicotherapy or Chinese traditional treatment; Variously intractablely cannot to perform the operation; Secondary or multiple relapse after rehabilitation; Invalid to Chinese and western medical therapy.

Medicine of the present invention, edible fungi polysaccharide composite formulations and preparation method:

(1) medicine, edible fungi formula: Cordyceps (Cordyceps militaris (L.) Link.), Auricularia polytricha (Mout) Sacc., Grifola frondosa, Hericium erinaceus (Bull. Ex Fr.) Pers., Ganoderma (Poria), Pleurotus tuber-regium, Lentinus Edodes (Lentinus Edodes), Morchella esculenta (L.) Pers, Poria, Polyporus, Phellinus igniarius (L. ex Fr.) Quel., schizophyllum commune, Pnoliota adiposa(Fr.) Quel., Sparassia crispa (Wulf.) Fr., Russula, Pleurotus ulmarius（ Bullex Franch） Quel, Tremella aurantialba Bandoni et Zang, Auricularia Sophorae, Tricholoma matsutake (lto et lmai) Singer, Pleurotus geesteranus, Pholiota nameko, Oudemansiella Radicata, cow tongue mushroom (bacterium), Herba Dendrobii, Radix Ginseng.

(2) preparation method: utilize enzymolysis flooding technology, ultra-filtration concentrates precipitate with ethanol technology, the fungus sporophore drying or dry was pulverized 40 mesh sieves, collects powder.Take edible and medical fungi dry powder appropriate, with the material-water ratio adding distil water of 1: 40,90% water bath with thermostatic control lixiviate 3h, filter paper filtering, centrifuging and taking supernatant (4000 γ min ^-1, 10min), then concentrated, repetition lixiviate once adds the ethanol of 4 times of volumes, hold over night.Carry out centrifugal again, gained precipitation uses acetone, washed with diethylether 3 times successively, dry to constant mass, get and fully dissolve with distilled water in right amount, solution is placed in bag filter, with tap water drip washing 48h, use distill water dialysis 24h again, then the dehydrated alcohol precipitate polysaccharides of 3 times of volumes is used, hold over night, 4000 γ min ^-1centrifugal, get precipitation after 10min.Lyophilization, to constant mass, is food, medicinal fungus polysaccharide that sugar content is 75.28%, makes polyoses capsule.

Because fungus polysaccharide complex of the present invention includes mannan, glucosan, glucose, fructose, galactose, maltose, cellobiose, fucose, polypeptide glucose, reducing sugar, the eleventh of the twelve Earthly Branches polysaccharide, trehalose, xylose etc.Also have multivitamin and Oudemansiella Radicata element, cow tongue plain, triterpenes, alkaloid, sterols composition and a small amount of glycopeptide.Therefore, this composite product enters in body, directly and the keeping path of the newborn micro-blood capillary of indirect cancerous cell, can impel cancerous cell atrophy.And produce initiative suicide tune and die.Have and stimulate and recover grandmother's Cells Hematopoietic function, improve peripheral blood leucocyte and content of hemoglobin; There is the lipofuscin content obviously reducing cardiac muscular tissue, superoxide dismutase alcohol vigor in reinforcement, thus the harmful substance such as oxygen-derived free radicals in purged body, there is good scavenging free radicals effect.

In an experiment, certain raw extract of this product kind is used to Therapeutic cancer.Its suppression ratio is 70% ~ 99.6%.And the mice secondary repeated infection after rehabilitation is not recurred.

This product pure natural, not containing additive, pigment and chemical extraction thing or synthetics.Safely, conveniently, have no side effect.Chemical reaction is not produced with any chemotherapeutics.

But notice that diet seafood or taboo take Chinese herbal medicine Herba Schizonepetae during use.

Claims

1. this 23 kinds of fungus polysaccharide composite product, it is characterized in that: with 23 kinds of organic medicals, food fungus sporophore---Cordyceps (Cordyceps militaris (L.) Link.), Auricularia polytricha (Mout) Sacc., Grifola frondosa, Hericium erinaceus (Bull. Ex Fr.) Pers., Ganoderma (Coriolous Dersicolor (Fr.) Quel), Pleurotus tuber-regium, Lentinus Edodes (Lentinus Edodes), Morchella esculenta (L.) Pers, Poria, Polyporus, Phellinus igniarius (L. ex Fr.) Quel., schizophyllum commune, Pnoliota adiposa(Fr.) Quel., Sparassia crispa (Wulf.) Fr., Russula, Pleurotus ulmarius（ Bullex Franch） Quel, Tremella aurantialba Bandoni et Zang, Auricularia Sophorae, Tricholoma matsutake (lto et lmai) Singer, Pleurotus geesteranus, Pholiota nameko, Oudemansiella Radicata, cow tongue mushroom and Herba Dendrobii, Radix Ginseng is compatible, dry or dry after pulverizing and cross 40 mesh sieves, obtain powder, adopt enzymolysis flooding technology, ultrafiltration and concentration precipitate with ethanol technology, taking precipitate lyophilization is to constant mass.Be medicine, food fungus polysaccharide---complex, post-treatment becomes capsule.