CN105154331A - Cell tensioning and pressing equipment - Google Patents
Cell tensioning and pressing equipment Download PDFInfo
- Publication number
- CN105154331A CN105154331A CN201510622630.7A CN201510622630A CN105154331A CN 105154331 A CN105154331 A CN 105154331A CN 201510622630 A CN201510622630 A CN 201510622630A CN 105154331 A CN105154331 A CN 105154331A
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- cell
- loading cells
- connecting rod
- cells device
- sliding part
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
- C12M35/04—Mechanical means, e.g. sonic waves, stretching forces, pressure or shear stimuli
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- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Sustainable Development (AREA)
- Microbiology (AREA)
- Mechanical Engineering (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The invention discloses cell tensioning and pressing equipment which comprises a power device. The power device comprises a body and a power output end, and the power output end outputs linear motion in the first direction. The cell tensioning and pressing equipment further comprises a motion switching mechanism connected to the power output end, a first cell loading device for bearing a cell culture vessel, and a supporting device, linear motion in the first direction is switched into linear motion in the second direction through the motion switching mechanism, and the first direction is perpendicular to the second direction. The first cell loading device is connected with the motion switching mechanism, and the first cell loading device can be operated to do linear motion in the second direction. The supporting device is used for supporting the first cell loading device. The cell tensioning and pressing equipment is very simple in structure.
Description
Technical field
The present invention relates to a kind of cell tension and compression equipment.
Background technology
Modern biotechnology research shows, the change of outside physiological environment can cellular function have an impact, and wherein mechanics factor plays vital effect to the growth of cell, differentiation, development and immune response.Therefore, research cell receives publicity increasingly by the reaction occurred after tractive or compression, becomes very required.
And current equipment can only carry out tractive or compression to cell, tractive and compression can not be carried out simultaneously, and complex structure, cost is higher.
Summary of the invention
The technical problem to be solved in the present invention is, provides a kind of cell tension and compression equipment, and this cell tension and compression device structure is simple.
The present invention is for solving the problems of the technologies described above adopted technical scheme:
A kind of cell tension and compression equipment, described cell tension and compression equipment comprises power set, and described power set comprises main body and clutch end, and described clutch end exports the translational motion on first direction; Wherein said cell tension and compression equipment also comprises: movement conversion mechanism, described movement conversion mechanism is connected to described clutch end, translational motion on first direction is transformed into the translational motion in second direction by described movement conversion mechanism, described first direction and second direction perpendicular; For carrying the first loading cells device of cell culture vessel, described first loading cells device is connected with described movement conversion mechanism, and described first loading cells device can by operatively along second direction translational motion; Bracing or strutting arrangement, described bracing or strutting arrangement is for supporting described first loading cells device.
The invention has the beneficial effects as follows, adopt the output power motion of end of movement conversion mechanism to convert the motion of the first loading cells device to, thus realize stretching or the compression of cell in cell culture vessel, structure is very simple.
Preferably, described movement conversion mechanism comprises web member, first connecting rod and the first sliding part, described web member is connected to described clutch end, one end of described first connecting rod is pivotally connected to described web member, the other end of described first connecting rod is pivotally connected to described first sliding part, and described first sliding part is connected to described first loading cells device, described first sliding part can operatively be driven described first loading cells device to move along second direction relative to described bracing or strutting arrangement.
Preferably, described cell pulling pressing device also comprises the second loading cells device for loading cell culture vessel, described movement conversion mechanism also comprises second connecting rod, the second sliding part, one end of described second connecting rod is pivotally connected to described web member, the other end of described second connecting rod is pivotally connected to described second sliding part, and described second sliding part is connected to described second loading cells device.
Preferably, described first connecting rod and second connecting rod are in same plane, and described first connecting rod and second connecting rod are angularly arranged.
Preferably, described first connecting rod and second connecting rod are coaxially connected to described web member.
Preferably, described first loading cells device and the second loading cells device are symmetrical arranged relative to described clutch end.
Preferably, the direction of motion of described first sliding part and the second sliding part is contrary.
Preferably, described first sliding part and the second sliding part are located along the same line.
Preferably, described bracing or strutting arrangement is fixed at described main body.
Preferably, described bracing or strutting arrangement has the installation portion that is installed on described main body and the support portion for supporting described first loading cells device, and described installation position is in the middle position of described support portion.
Preferably, described first loading cells device has the first installation site and the second installation site relative to described first sliding part, when described first loading cells device is located at the first installation site, when described first loading cells device can operatively be moved, cell in cell culture vessel is stretched, when the first loading cells device is located at the second installation site, when described first loading cells device can operatively be moved, the cell in described cell culture vessel is compressed.
Accompanying drawing explanation
Above-described object of the present invention, technical scheme and beneficial effect by the detailed description that can realize specific embodiments of the invention below, can describe and clearly obtain simultaneously by reference to the accompanying drawings.
Identical label in accompanying drawing and specification sheets and symbol are for representing identical or equivalent element.
Fig. 1 shows the front view of the cell tension and compression equipment that the embodiment of the present invention provides.
Fig. 2 shows the partial enlarged drawing of the cell tension and compression equipment in Fig. 1, now removes power set.
Fig. 3 shows the vertical view of the cell tension and compression equipment that the embodiment of the present invention provides, and now removes power set.
Wherein: 8. power set, 10. main body, 12. clutch ends, 14. movement conversion mechanisms, 16. first loading cells devices, 18. bracing or strutting arrangements, 20. web members, 22. first connecting rods, 24. first sliding parts, 26. connecting holes, 28. second loading cells devices, 30. second connecting rods, 30. second connecting rods, 34. installation portions, 36. support portions, 38. guide parts, 40. stop parts, 42. locating parts, 44. first open holess, 46. second open holess, 50. bearing pins.
Embodiment
As shown in Figure 1, Figure 2 and Figure 3, a kind of cell tension and compression equipment, cell tension and compression equipment comprises power set 8, and power set 8 comprises main body 10 and clutch end 12, and clutch end 12 exports the translational motion on first direction.Wherein cell tension and compression equipment also comprises movement conversion mechanism 14, movement conversion mechanism 14 is connected to clutch end 12, and the translational motion on first direction is transformed into the translational motion in second direction by movement conversion mechanism 14, first direction and second direction perpendicular.
The first loading cells device 16, first loading cells device 16 that cell pulling pressing device also comprises for carrying cell culture vessel (not shown) is connected with movement conversion mechanism 14; First loading cells device 16 can by operatively along second direction translational motion, and bracing or strutting arrangement 18, bracing or strutting arrangement 18 is for supporting the first loading cells device 16.
In this preferred embodiment, the motion that the clutch end 12 of power set 8 exports is the motion of vertically going up, and that is first direction is vertical direction, and accordingly, second direction is horizontal direction.Usual cell cultures needs horizontal positioned, and therefore movement conversion mechanism 14 needs the motion that the motion on vertical direction is converted in horizontal direction.Like this, just stretchy loading cells device upper motion in the horizontal direction, thus stretch or compression cell.
In the preferred embodiments of the present invention, adopt the output power motion of end 12 of movement conversion mechanism 14 to convert the motion of the first loading cells device 16 to, thus realize stretching or the compression of cell, structure is very simple.
Concrete, movement conversion mechanism 14 comprises web member 20, first connecting rod 22 and the first sliding part 24, and web member 20 is connected to clutch end 12, in this preferred embodiment, web member 20 is provided with connecting hole 26, by latch (not shown), web member 20 is fixedly connected on clutch end 12.Certainly, also other mode of connection can be adopted.One end of first connecting rod 22 is pivotally connected to web member 20 in addition, the other end of first connecting rod 22 is pivotally connected to the first sliding part 24, and the first sliding part 24 is connected to the first loading cells device 16, first sliding part 24 can operatively be driven the first loading cells device 16 to move along second direction relative to bracing or strutting arrangement 18.Certainly, movement conversion mechanism 14 also can be arranged to other structure formation, as long as the motion on first direction can be converted to second direction.
Further, described cell pulling pressing device also comprises the second loading cells device 28 for loading cell culture vessel, movement conversion mechanism 14 also comprises second connecting rod 30, second sliding part 32, with, one end of second connecting rod 30 is pivotally connected to web member 20, the other end of second connecting rod 30 is pivotally connected to the second sliding part 32, and the second sliding part 32 is connected to the second loading cells device 28.Concrete, the direction of motion of the first sliding part 24 and the second sliding part 32 is contrary.In addition, the first sliding part 24 and the second sliding part 32 are located along the same line.Certainly, also can not arrange point-blank.
Owing to being provided with the second loading cells device 28, considerably increasing single job and just can carry out stretching or the experimental amount of compression experiment.
In this preferred embodiment, bracing or strutting arrangement 18 is fixed at main body 10.Certainly, also bracing or strutting arrangement 18 can be fixed on another one platform, as long as bracing or strutting arrangement 18 maintains static just passable.
Bracing or strutting arrangement 18 has the installation portion 34 that is installed on main body 10 and the support portion 36 for supporting the first loading cells device 16, and installation portion 34 is positioned at the middle position of support portion 36.
In addition, bracing or strutting arrangement 18 being also provided with guide part 38, moving along second direction for limiting the first sliding part 24.
First loading cells device 16 comprises locating part 42 that stop part 40 is connected with the first sliding part 24 and is located between stop part 40 and locating part 42 for holding cell culture vessel (not shown), stop part 40 is removably located on bracing or strutting arrangement 18, and locating part 42 is located on bracing or strutting arrangement 18 slippingly.Culture vessel adopts the elastic material being easy to deformation.
In addition, first loading cells device 16 has the first installation site and the second installation site relative to the first sliding part 24, when the first loading cells device 16 is located at the first installation site, when first loading cells device 16 can operatively be moved, cell in cell culture vessel is stretched, when the first loading cells device 16 is located at the second installation site, when the first loading cells device 16 can operatively be moved, the cell in cell culture vessel is compressed.After the cell in cell culture vessel is stretched or compressed, stop part 40, locating part 42 is removed together with culture vessel, the cell in culture vessel is analyzed.
Concrete, the first sliding part 24 is provided with the first open holes 44 and the second open holes 46, and locating part 42 is connected with the first sliding part 24 by bearing pin 50.When locating part 42 and the first open holes 44 are assembled together by bearing pin 50, the cell in cell culture vessel is stretched.When locating part 42 and the second open holes 46 are assembled together by bearing pin 50, the cell in cell culture vessel is compressed.First open holes 44 relative to the second open holes 46 closer to first connecting rod 22.
In this preferred embodiment, the first loading cells device 16 is identical with the second loading cells device 28, is no longer described in detail at this.Certainly, the first loading cells device 16 also can be arranged to not identical with the second loading cells device 28.
In addition, first connecting rod 22 and second connecting rod 30 are in same plane, and first connecting rod 22 and second connecting rod 30 are angularly arranged.
In this preferred embodiment, first connecting rod 22 and second connecting rod 30 are coaxially connected to web member 20.So, make structure simpler, compact.Certainly, first connecting rod 22 and second connecting rod 30 also can be arranged to disalignment and be connected to web member 20.
Moreover the first loading cells device 16 and the second loading cells device 28 are symmetrical arranged relative to clutch end 12.
Above embodiment is only the present invention's one, two kinds of embodiments wherein, and it describes comparatively concrete and detailed, but therefore can not be interpreted as the restriction to the scope of the claims of the present invention.It should be pointed out that for the person of ordinary skill of the art, under the prerequisite not departing from inventive concept of the present invention, can also make some distortion and improvement, these all belong to protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
Claims (11)
1. a cell tension and compression equipment, described cell tension and compression equipment comprises power set, and described power set comprises main body and clutch end, and described clutch end exports the translational motion on first direction, it is characterized in that: described cell tension and compression equipment also comprises:
Movement conversion mechanism, described movement conversion mechanism is connected to described clutch end, and the translational motion on first direction is transformed into the translational motion in second direction by described movement conversion mechanism, described first direction and second direction perpendicular;
For carrying the first loading cells device of cell vessel, described first loading cells device is connected with described movement conversion mechanism, and described first loading cells device can by operatively along second direction translational motion;
Bracing or strutting arrangement, described bracing or strutting arrangement is for supporting described first loading cells device.
2. cell tension and compression equipment according to claim 1, it is characterized in that: described movement conversion mechanism comprises web member, first connecting rod and the first sliding part, described web member is connected to described clutch end, one end of described first connecting rod is pivotally connected to described web member, the other end of described first connecting rod is pivotally connected to described first sliding part, and described first sliding part is connected to described first loading cells device, described first sliding part can operatively be driven described first loading cells device to move along second direction relative to described bracing or strutting arrangement.
3. cell tension and compression equipment according to claim 2, it is characterized in that: described cell pulling pressing device also comprises the second loading cells device for loading cell vessel, described movement conversion mechanism also comprises second connecting rod, the second sliding part, one end of described second connecting rod is pivotally connected to described web member, the other end of described second connecting rod is pivotally connected to described second sliding part, and described second sliding part is connected to described second loading cells device.
4. cell tension and compression equipment according to claim 3, it is characterized in that: described first connecting rod and second connecting rod are in same plane, and described first connecting rod and second connecting rod is angularly arranged.
5. cell tension and compression equipment according to claim 3, is characterized in that: described first connecting rod and second connecting rod are coaxially connected to described web member.
6. cell tension and compression equipment according to claim 3, is characterized in that: described first loading cells device and the second loading cells device are symmetrical arranged relative to described clutch end.
7. cell tension and compression equipment according to claim 3, is characterized in that: the direction of motion of described first sliding part and the second sliding part is contrary.
8. cell tension and compression equipment according to claim 3, is characterized in that: described first sliding part and the second sliding part are located along the same line.
9. cell tension and compression equipment according to claim 2, is characterized in that: described bracing or strutting arrangement is fixed at described main body.
10. cell tension and compression equipment according to claim 9, it is characterized in that: described bracing or strutting arrangement has the installation portion that is installed on described main body and the support portion for supporting described first loading cells device, and described installation position is in the middle position of described support portion.
11. cell tension and compression equipment according to claim 2, it is characterized in that: described first loading cells device has the first installation site and the second installation site relative to described first sliding part, when described first loading cells device is located at the first installation site, when described first loading cells device can operatively be moved, cell in cell culture vessel is stretched, when the first loading cells device is located at the second installation site, when described first loading cells device can operatively be moved, the cell in described cell culture vessel is compressed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510622630.7A CN105154331B (en) | 2015-09-28 | 2015-09-28 | Cell tension and compression equipment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510622630.7A CN105154331B (en) | 2015-09-28 | 2015-09-28 | Cell tension and compression equipment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105154331A true CN105154331A (en) | 2015-12-16 |
| CN105154331B CN105154331B (en) | 2017-11-03 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510622630.7A Active CN105154331B (en) | 2015-09-28 | 2015-09-28 | Cell tension and compression equipment |
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| Country | Link |
|---|---|
| CN (1) | CN105154331B (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1932510A (en) * | 2006-09-22 | 2007-03-21 | 重庆大学 | Cell tensile loader |
| CN1932511A (en) * | 2006-09-22 | 2007-03-21 | 重庆大学 | Sinusoidal tensile cell loader |
| CN102943042A (en) * | 2012-12-06 | 2013-02-27 | 天津理工大学 | Combined multifunctional bioreactor |
| CN202881283U (en) * | 2012-07-09 | 2013-04-17 | 舒茂国 | Cell culture dish capable of providing tractive mechanical stress |
| CN103512803A (en) * | 2013-09-26 | 2014-01-15 | 吉林大学 | Multi-load and multi-physics coupling material micromechanical performance in-situ testing instrument |
| CN103528887A (en) * | 2013-10-24 | 2014-01-22 | 吉林大学 | In-situ pull/press-torque combined load material micromechanics test platform |
-
2015
- 2015-09-28 CN CN201510622630.7A patent/CN105154331B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1932510A (en) * | 2006-09-22 | 2007-03-21 | 重庆大学 | Cell tensile loader |
| CN1932511A (en) * | 2006-09-22 | 2007-03-21 | 重庆大学 | Sinusoidal tensile cell loader |
| CN202881283U (en) * | 2012-07-09 | 2013-04-17 | 舒茂国 | Cell culture dish capable of providing tractive mechanical stress |
| CN102943042A (en) * | 2012-12-06 | 2013-02-27 | 天津理工大学 | Combined multifunctional bioreactor |
| CN103512803A (en) * | 2013-09-26 | 2014-01-15 | 吉林大学 | Multi-load and multi-physics coupling material micromechanical performance in-situ testing instrument |
| CN103528887A (en) * | 2013-10-24 | 2014-01-22 | 吉林大学 | In-situ pull/press-torque combined load material micromechanics test platform |
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| Publication number | Publication date |
|---|---|
| CN105154331B (en) | 2017-11-03 |
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