CN105147755A - Chickenpox-resistant traditional Chinese medicine composite and preparation method and application thereof - Google Patents
Chickenpox-resistant traditional Chinese medicine composite and preparation method and application thereof Download PDFInfo
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- CN105147755A CN105147755A CN201510715640.5A CN201510715640A CN105147755A CN 105147755 A CN105147755 A CN 105147755A CN 201510715640 A CN201510715640 A CN 201510715640A CN 105147755 A CN105147755 A CN 105147755A
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Abstract
The invention discloses a chickenpox-resistant traditional Chinese medicine composite and a preparation method and application thereof. The traditional Chinese medicine composite is prepared from, by weight, 25-35 parts of geranium wilfordii, 1-4 parts of viscum album and 22-28 parts of periploca sepium. The preparation method comprises the steps of adding geranium wilfordii, viscum album and periploca sepium into water with mass 10-13 times total mass of the raw materials, boiling the mixture with strong fire, then turning the strong fire to slow fire, conducting decoction for two to three hours, and obtaining the chickenpox-resistant traditional Chinese medicine composite. Medicine ingredients in the chickenpox-resistant traditional Chinese medicine composite are dialectically compatible and supplement one another in function, synergism is achieved, and the composite has the effects of clearing away heat and toxic materials, dispelling wind, eliminating stagnation, cooling the blood and dissolving purpura and is used for treating chickenpox. Natural traditional Chinese medicine raw materials are adopted as the ingredients in the composite, and the medicament is safe and reliable. The composite is easy and convenient to prepare, wide in medicinal resource and low in cost. The composite needs to be decocted with water before being taken. Clinical application verifies that the composite is definite in curative effect, quick in effectiveness production, high in cure rate and free of side effect, the total effective rate is over 95%, and the cure rate reaches over 80%.
Description
Technical field
The present invention relates to field of medicaments, specifically a kind of Chinese medicine composition and its production and use of water resistant pox.
Background technology
Chickenpox is the acute infectious disease caused by varicella-zoster virus primary infection.Infectious rate is very high.Mainly occur in infant, to generate heat and to occur that whole body property red grouper pimple, herpes, crust rash are for feature in batch.Winter and spring is multiple, and its infectivity is strong, and contact or the spittle all can infect.Susceptible sickness rate can reach more than 95%, and preschooler is common.Clinically occur maculopapule, vesicle and incrustation with skin mucosa, and each phase erythra exists for feature simultaneously in batches.This disease is self-limited disease, can obtain lifetime immunity after being ill, also can occur herpes zoster in postoperative infection recurrence for many years.
The clinical manifestation of chickenpox: this disease incubation period is 12 ~ 21, average 14 days.Onset is anxious, light, moderate is generated heat and occurs erythra, and erythra is first sent out in scalp, trunk part in compression, distributes in centration.Within the eruptive stage of 1 ~ 6 day by a definite date, erythra occurs in succession in batches.Skin lesion presents the evolution process by the pimple → herpes → incrustation → decrustation of tiny red grouper, does not stay skin trace after decrustation.Water scar phase sufferings are obvious, if because leaving slight indenture when scratching and grab secondary infection.Can be there is high heat in weakling, dissemination chickenpox, varicella pneumonia can occur the adult of about 4%.Be more common in greatly the child of 1 ~ 10 years old, 2 ~ 3 weeks incubation periods.Onset is comparatively anxious, can have the prodromes such as heating, headache, general lassitude.There is erythra in morbidity in 24 hours, immediately become the grain of rice to pea-sized round nervous vesicle, around obvious blush, have the central authorities of vesicle to be omphalos shape.Through the dry incrustation of vesicle in 2 ~ 3 days, crust was de-and heal, and does not stay cicatrix.Skin lesion is centration distribution, first begins from front face portion, after see trunk, extremity.How much indefinite number is is many with trunk, and inferior to face, head, extremity are less, and the palm sole of the foot is less.Mucosa is also often invaded, and sees oral cavity, pharyngeal, the place such as eye conjunctiva, pudendum, anus.Skin lesion often occurs in batches, and thus pimple, vesicle and incrustation often exist simultaneously, and the course of disease was through 2 ~ 3 weeks.If when infant is lower for the resistance, skin lesion can Progressive symmetric erythrokeratodermia generalized dissemination, forms dissemination chickenpox.The clinical abnormal shape performance of chickenpox has: epidermolysis chickenpox, hemorrhagic varicella, neonatal varicella, adult varicella etc.In addition, if trimester of pregnancy infects chickenpox, fetal anomaly, premature labor or stillborn fetus can be caused.
Chickenpox is anti symptom treatment mainly.Patient should isolate.Because it is by transmitted by droplets and direct contact, infectiousness is very strong, and susceptible person 80%-90% falls ill, and therefore must tightly isolate disease and treat as early as possible.Mainly select acyclovir, vitamin C, folic acid clinically, it is oral that severe patient adds persantin; In addition, Measles Vaccine,Live treatment chickenpox successful, but Western medicine direct effect internal organs, easily to the side effect that human body brings.
Summary of the invention
The object of the present invention is to provide that a kind of determined curative effect, instant effect, cure rate are high, the Chinese medicine composition of water resistant pox that has no side effect and its production and use, to solve the problem proposed in above-mentioned background technology.
For achieving the above object, the invention provides following technical scheme:
A Chinese medicine composition for water resistant pox, is made up of the following raw material according to weight portion: Herba Erodii 25-35 part, Herba Visci 1-4 part, Cortex Periplocae 22-28 part.
As the further scheme of the present invention: the Chinese medicine composition of described water resistant pox, be made up of the following raw material according to weight portion: Herba Erodii 28-32 part, Herba Visci 2-3 part, Cortex Periplocae 24-26 part.
As the further scheme of the present invention: the Chinese medicine composition of described water resistant pox, be made up of the following raw material according to weight portion: Herba Erodii 30 parts, Herba Visci 3 parts, Cortex Periplocae 25 parts.
The preparation method of the Chinese medicine composition of described water resistant pox, Herba Erodii, Herba Visci, Cortex Periplocae are added raw material gross mass 10-13 water doubly, and intense fire is boiled, and then transfers slow fire to, decocts 2-3h, obtains the Chinese medicine composition of water resistant pox.
The application of described Chinese medicine composition in the medicine for the preparation of water resistant pox.
In the present invention, Herba Erodii is dispeled the wind, and invigorates blood circulation, heat-clearing and toxic substances removing.Dispelling the wind and dampness pathogens pain, contracture is numb, carbuncle, traumatic injury, enteritis, dysentery.Herb decoct has obvious inhibitory action to people's micrococcus catarrhalis, staphylococcus aureus, shigella flexneri, group B streptococcus, apex pulmonis coccus etc. in vitro, wherein contained tannin has a certain impact to its bacteriostasis, has obvious inhibitory action to the section 68-1 strain of influenza A virus capital, Asia and the strain of hemagglutinating virus of Japan celestial platform.Antivirus action: herb decoct has obvious inhibitory action (by Embryo Gallus domesticus, with hemagglutination test) to section 68 11 strain of influenza A virus capital, Asia and the strain of parainfluenza virus I type celestial platform.In addition, Herba Erodii also there is antidiarrheal, blood coagulation, eliminate the phlegm, anthelmintic, the effect such as diuresis.
Herba Visci is containing flavone compound: 3 '-rhamnazin (rham-nazin), 3 '-rhamnazin-3-glycoside (rhamnzin-3-O-β-D-glucoside), isorhamnetin-3-glycoside (isorhamnetin-3-O-β-D-gluco-side), isorhamnetin-7-glycoside (isorhamnetin-7-O-β-D-glucoside), 3 '-methyl eriodictyol (3-methyleriodictyol), 3 '-methyl eriodictyol-7-glycoside (3 '-methylerlodictyol-7-O-β-D-glucoside) posts glycoside first also known as Mongolian oak, viscumneoside (viscumneoside) I, II, III, IV, V, VI, VII.Also containing triterpenoid compound: β-Amyrin (β-amyranol); β-acetyl group Amyrin (β-acety-lamyranol); β-erythordiol (β-amyrandiol); lupeol (lupeol); oleanolic acid (oleanolicacid); white firelight or sunlight fat acid (betulicacid); palm fibre acid-β mutually-balsam alcohol ester (β-amyrinpalmitate); acetic acid-β-balsam alcohol ester (β-amyrinacetate); cupreol (β-sitosterol), daucosterol (daucosterol).Also containing other glycoside: Syringin (syringin), syringenin-O-β-D-furan celery glycosyl (1 → 2)-β-D-glucopyranose (syringenin-O-β-D-apio-furanosyl (1 → 2)-β-D-glu-copyranoside), Liriodendron glycoside (liriodendrin), 2, the single glycoside (butan-2,3-diol-3-O-monoglucoside) of 3-butanediol-3-O-.Again containing meso inositol (meso-inositol), Palmic acid (palmiticacid), succinic acid (succinicacid), ferulic acid (ferulicacid), caffeic acid (caffeicacid), the organic acid such as protocatechuic acid (pro-tocatechuicacid).Herba Visci has relaxing muscles and tendons and activating QI and blood in the collateral, promoting blood circulation to remove blood stasis.For bones and muscles pain, limbs contracture, aching pain in waist and back, traumatic injury.Invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling, the effect such as antiabortive, Herba Visci extract can improve microcirculation, and its total alkaloids also has antitumor action.
Cortex Periplocae has inducing diuresis to remove edema, wind-damp dispelling, effect of bone and muscle strengthening.Be used for the treatment of edema of lower limbs, shortness of breath and palpitation, anemofrigid-damp arthralgia, soreness of the waist and knees.
Compared with prior art, the invention has the beneficial effects as follows:
Drug component in the present invention, through dialectical compatibility, complements each other using, has synergism, have effect of heat-clearing and toxic substances removing, dispelling wind eliminating stagnation, cooling blood and dissolving purpura, be used for the treatment of chickenpox.Component in the present invention all adopts natural raw material of Chinese medicine, and safety of medicine is reliable.Its preparation is easy, medicine source is wide, cost is low.The use that is decocted in water for oral dose is adopted when taking.Through clinical practice checking, its determined curative effect, instant effect, cure rate be high, have no side effect, and total effective rate more than 95%, cure rate reaches more than 80%.
Detailed description of the invention
Below in conjunction with the embodiment of the present invention, be clearly and completely described the technical scheme in the embodiment of the present invention, obviously, described embodiment is only the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
Embodiment 1
In the embodiment of the present invention, a kind of Chinese medicine composition of water resistant pox, is made up of the following raw material according to weight portion: Herba Erodii 25 parts, Herba Visci 1 part, Cortex Periplocae 22 parts.Herba Erodii, Herba Visci, Cortex Periplocae are added the water of raw material gross mass 10 times, intense fire is boiled, and then transfers slow fire to, decocts 2h, obtains the Chinese medicine composition of water resistant pox.
Embodiment 2
In the embodiment of the present invention, a kind of Chinese medicine composition of water resistant pox, is made up of the following raw material according to weight portion: Herba Erodii 35 parts, Herba Visci 4 parts, Cortex Periplocae 28 parts.Herba Erodii, Herba Visci, Cortex Periplocae are added the water of raw material gross mass 13 times, intense fire is boiled, and then transfers slow fire to, decocts 3h, obtains the Chinese medicine composition of water resistant pox.
Embodiment 3
In the embodiment of the present invention, a kind of Chinese medicine composition of water resistant pox, is made up of the following raw material according to weight portion: Herba Erodii 28 parts, Herba Visci 2 parts, Cortex Periplocae 24 parts.Herba Erodii, Herba Visci, Cortex Periplocae are added the water of raw material gross mass 11 times, intense fire is boiled, and then transfers slow fire to, decocts 2.3h, obtains the Chinese medicine composition of water resistant pox.
Embodiment 4
In the embodiment of the present invention, a kind of Chinese medicine composition of water resistant pox, is made up of the following raw material according to weight portion: Herba Erodii 32 parts, Herba Visci 3 parts, Cortex Periplocae 26 parts.Herba Erodii, Herba Visci, Cortex Periplocae are added the water of raw material gross mass 12 times, intense fire is boiled, and then transfers slow fire to, decocts 2.7h, obtains the Chinese medicine composition of water resistant pox.
Embodiment 5
In the embodiment of the present invention, a kind of Chinese medicine composition of water resistant pox, is made up of the following raw material according to weight portion: Herba Erodii 30 parts, Herba Visci 3 parts, Cortex Periplocae 25 parts.Herba Erodii, Herba Visci, Cortex Periplocae are added the water of raw material gross mass 11.5 times, intense fire is boiled, and then transfers slow fire to, decocts 2.5h, obtains the Chinese medicine composition of water resistant pox.
For the curative effect of proved invention treatment chickenpox, with the Chinese medicine composition that embodiment of the present invention 1-5 is obtained, carry out following experimental study:
1 data and method
1.1 physical data
All cases is totally 240 examples, is divided into treatment group 1-5 and control group A-C at random, often organizes 30 examples.Often organize sex, age through statistics there was no significant difference (P>0.05), there is comparability.
1.2 case selection inclusion criterias: make a definite diagnosis with reference to " practical paidonosology " diagnostic criteria: there is chickenpox contact history; Show as typical rash, maculopapule, herpes, incrustation occur simultaneously, distribute, have scratchiness, with heating in centration; Peripheral blood routine examination total white blood cells is normal or on the low side, classifies based on lymphocyte.
1.3 Therapeutic Method: control group A suiting the medicine to the illness, Calamine Lotion to be coated with outward etc. on general treatment basis and to add with acyclovir, only have Herba Erodii and Herba Visci in matched group B, all the other are consistent with embodiment 5.Only have Cortex Periplocae in matched group C, all the other are consistent with embodiment 5.Treatment group when taking, daily 3 times.
1.4 curative effect determinate standards: 1. cure: 24 ~ 48h interior-heat moves back, original erythra incrustation, occurs without new erythra; 2. effective: 48 ~ 72h interior-heat moves back, original erythra incrustation, occurs without new erythra; 3. invalid: to generate heat after 72h and do not move back, original erythra does not form a scab, and has new erythra to occur.
1.5 statistical procedures adopt SPSS13.0 statistical software to carry out date processing, and measurement data represents with mean ± standard deviation (x ± s), and adopt t inspection, enumeration data adopts x
2inspection.
2 results
2.1 Clinical efficacy comparisons, through statistics, the results are shown in Table 1.
Table 1
| Group | Number of cases | Cure | Effectively | Invalid | Total effective rate |
| Embodiment 1 | 30 | 24(80％) | 5(16.7％) | 1(3.3％) | 96.7％ |
| Embodiment 2 | 30 | 25(83.4％) | 4(13.3％) | 1(3.3％) | 96.7％ |
| Embodiment 3 | 30 | 26(86.7％) | 4(13.3％) | 0 | 100％ |
| Embodiment 4 | 30 | 28(93.3) | 2(6.7％) | 0 | 100％ |
| Embodiment 5 | 30 | 30(100) | 0 | 0 | 100％ |
| Control group A | 30 | 20(66.7％) | 2(6.6％) | 8(26.7％) | 73.3％ |
| Matched group B | 30 | 1(10％) | 10(26.7％) | 19(63.3％) | 36.7％ |
| Matched group C | 30 | 0 | 3(10％) | 27(90％) | 10％ |
3 conclusions
The present invention, on the basis of western medicine routine treatment, adds Drug therapy of the present invention, and in raising clinical efficacy, be all better than simple western medical treatment, abundant proved invention medicine has significant clinical efficacy to chickenpox.And embodiment 3-4 effect is better than embodiment 1-2, the curative effect of embodiment 5 is best.When can find out that from matched group B the present invention only has independent two taste medicine Herba Erodiis, Herba Visci, therapeutic effect is very poor, but after adding Cortex Periplocae, total effective rate reaches 100%.When can find out that from matched group C the present invention only has Cortex Periplocae, therapeutic effect is very poor.
Model case
Case 1: single certain, female, 9 years old.Within medical first 2 days, occur heating fear of cold, pharyngalgia is had a headache, and the whole body is uncomfortable, and the general rubescent mottle pimple of whole skin, vesicle companion sufferings pruritus, be diagnosed as chickenpox then.Take Chinese medicine composition of the present invention 2 days, temperature decline is to normal, and the malaise symptoms such as pharyngalgia, headache alleviates, and original erythra incrustation, without new breakout; Continue to take above-mentioned medicament 3 days, the incrustation of drying up of pimple, vesicle comes off, and all diseases disappear, and cures.
Case 2: Wang, man, 6 years old.Time medical, heating, swallows red, and the whole body is uncomfortable, and pimple appears in head, eye, trunk and lower limb, and pox is large and close, and rash is itched, and minority is diabrosis, is diagnosed as chickenpox.Take Chinese medicine composition of the present invention 3 days, the symptoms such as heating alleviate, and original erythra incrustation, occurs without new erythra; Continue and take 5 days, temperature recovery is normal, and pimple is received not, and diabrosis place receives crust, comes off and asks for sick leave more.
To those skilled in the art, obviously the invention is not restricted to the details of above-mentioned one exemplary embodiment, and when not deviating from spirit of the present invention or basic feature, the present invention can be realized in other specific forms.Therefore, no matter from which point, all should embodiment be regarded as exemplary, and be nonrestrictive, scope of the present invention is limited by claims instead of above-mentioned explanation, and all changes be therefore intended in the implication of the equivalency by dropping on claim and scope are included in the present invention.
In addition, be to be understood that, although this description is described according to embodiment, but not each embodiment only comprises an independently technical scheme, this narrating mode of description is only for clarity sake, those skilled in the art should by description integrally, and the technical scheme in each embodiment also through appropriately combined, can form other embodiments that it will be appreciated by those skilled in the art that.
Claims (5)
1. a Chinese medicine composition for water resistant pox, is characterized in that, is made up of the following raw material according to weight portion: Herba Erodii 25-35 part, Herba Visci 1-4 part, Cortex Periplocae 22-28 part.
2. the Chinese medicine composition of water resistant pox according to claim 1, is characterized in that, is made up of the following raw material according to weight portion: Herba Erodii 28-32 part, Herba Visci 2-3 part, Cortex Periplocae 24-26 part.
3. the Chinese medicine composition of water resistant pox according to claim 2, is characterized in that, is made up of the following raw material according to weight portion: Herba Erodii 30 parts, Herba Visci 3 parts, Cortex Periplocae 25 parts.
4. the preparation method of the Chinese medicine composition of the water resistant pox as described in as arbitrary in claim 1-3, is characterized in that, Herba Erodii, Herba Visci, Cortex Periplocae are added raw material gross mass 10-13 water doubly, intense fire is boiled, and then transfer slow fire to, decoct 2-3h, obtain the Chinese medicine composition of water resistant pox.
5. the application of Chinese medicine composition in the medicine for the preparation of water resistant pox as described in as arbitrary in claim 1-3.
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| CN102872369A (en) * | 2012-09-25 | 2013-01-16 | 王雪娟 | Traditional Chinese medicine composition for varicella treatment |
| CN103720797A (en) * | 2013-12-12 | 2014-04-16 | 吉林省现代中药工程研究中心有限公司 | Foot bath external use traditional Chinese medicine for treating rheumatism |
| KR101493461B1 (en) * | 2014-05-15 | 2015-02-16 | 순천향대학교 산학협력단 | Composition Comprising Deoxypergularinine and the Extract of Cynanchum atratum against tuberculosis |
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Application publication date: 20151216 |