CN105137613A - Preparation method of chitosan oligosaccharide antibacterial contact lenses - Google Patents
Preparation method of chitosan oligosaccharide antibacterial contact lenses Download PDFInfo
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- CN105137613A CN105137613A CN201510620699.6A CN201510620699A CN105137613A CN 105137613 A CN105137613 A CN 105137613A CN 201510620699 A CN201510620699 A CN 201510620699A CN 105137613 A CN105137613 A CN 105137613A
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- contact lenses
- chitosan oligosaccharide
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- G—PHYSICS
- G02—OPTICS
- G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
- G02C7/00—Optical parts
- G02C7/02—Lenses; Lens systems ; Methods of designing lenses
- G02C7/04—Contact lenses for the eyes
- G02C7/049—Contact lenses having special fitting or structural features achieved by special materials or material structures
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- G—PHYSICS
- G02—OPTICS
- G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
- G02C7/00—Optical parts
- G02C7/02—Lenses; Lens systems ; Methods of designing lenses
- G02C7/04—Contact lenses for the eyes
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- Health & Medical Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Eyeglasses (AREA)
Abstract
The invention relates to a preparation method of chitosan oligosaccharide antibacterial contact lenses, and belongs to the field of contact lenses, which aims at solving the problems that the existing contact lenses material is poor in antibacterial performance, the inflammation of eyes is caused by the infection of bacteria, and the health is harmed. Chitosan is ultrasonically degraded in an assisting manner to prepare chitosan oligosaccharide, and then the chitosan oligosaccharide having excellent antibacterial performance is used for preparing the contact lenses, so that the sanitation and health of the eyes when the contact lenses are worn can be effectively guaranteed. The prepared chitosan oligosaccharide antibacterial contact lenses are excellent in antibacterial performance, the quantity of bacteria on the lenses is reduced by 90 percent compared with an ordinary lens after the chitosan oligosaccharide antibacterial contact lenses are worn by people for one months; meanwhile, the natural chitosan is used for preparing the contact lenses, so that the contact lenses can be effectively matched with the cornea of the human body and is non-irritant to the human body.
Description
Technical field
The present invention relates to a kind of preparation method of chitosan oligosaccharide antimicrobial contact lenses, belong to contact lens art.
Background technology
Contact lenses (contactlens), are also contact lens, are that one is worn on cornea, in order to correct defects of vision or to protect the eyeglass of eyes.According to the soft or hard of material, it comprises rigid, semi-hard, soft three kinds, contact lenses are not only from bringing very large improvement to convenience aspect in appearance the ametropia patients such as myopia, long sight, astigmatism, and the visual field is broad, to look thing true to nature, this external control adolescent myopia, astigmatism develop, and treat the aspects such as special illness in eye and have also played special effect.Today that introduction is being followed the fashion, all kinds of contact lenses emerge in an endless stream, and the contact lenses of frivolous fashion occupy windward, thus instead of the position of frame eyeglasses.Frivolous contact lenses are that one is worn on cornea, in order to correct defects of vision or to protect the eyeglass of eyes.The arrival of contact lenses gives us from appearance with ready-to-use type, has all brought and has greatly taken on a new look.
But long periods of wear contact lenses, the health problem that contact lenses cause, increasing, have the wearer of intimate half, because ignore the disinfecting cleaning to contact lenses, and cause cornea inflammation, therefore, contact lens must focus on health.Doctors find, a lot of people can contact lens for a long time, and this is the key factor causing the eye illnesses such as bacterial keratitis.Contact lenses are the foreign matter be placed on cornea after all, blinking each time of eyes, all can make contact lenses and eyeball surface produce certain friction, and it covers the surface of cornea simultaneously, cornea is made to be difficult to directly draw oxygen from air, so for a long time or continuously contact lens, all can make cornea be in lasting anaerobic condition, cause corneal epithelium edema, erosion, if have bacterium or virus to exist, just may cause keratitis, even form ulcer of the cornea.So, particularly important to the requirement of the antibacterial of contact lenses and biocidal property.
Summary of the invention
Technical matters to be solved by this invention: poor for current contact lens material anti-microbial property, easy infection bacterium causes glasses inflammation, the problem of health risk, provide a kind of degraded by shitosan ultrasonic assistant and prepare chitosan oligosaccharide, adopt the splendid chitosan oligosaccharide of anti-microbial property to prepare the method for contact lenses again, effectively ensure that health and the health of eyes during contact lens.
For solving the problems of the technologies described above, the present invention adopts technical scheme as described below to be:
(1) by the acetate-sodium acetate buffer of solid-liquid mass ratio 1:5 by shitosan and 0.2mol/L, at 30 ~ 40 DEG C under 300 ~ 400r/min rotating speed, be uniformly mixed 20 ~ 50min, be mixed with the chitosan gum liquid solution that massfraction is 2%;
(2) colloidal solution preparation obtained and enzymatic activity are the pectase of 1500 ~ 1800U/g, be uniformly mixed by the mass ratio of 20:1, and the ultrasonic assistant vibration under being placed in 80 ~ 100W, at 50 ~ 60 DEG C, 300 ~ 500r/min stirring at low speed, 3 ~ 5h, obtains enzymolysis colloidal solution;
(3) to be mixed complete after, continue to be heated to 90 ~ 95 DEG C to enzymolysis colloidal solution, go out after ferment treatment 10 ~ 15min, be placed in hydro-extractor, under 5000 ~ 6000r/min, high speed centrifugation is separated, and collects supernatant subsequently, and carries out suction filtration removal of impurities by the miillpore filter of 10 μm, collect filtered fluid and be placed in that Rotary Evaporators is concentrated into original volume 1/3, obtain chitosan oligosaccharide concentrate;
(4) count by weight, choose the chitosan oligosaccharide concentrate of 20 ~ 59 parts of preparations, 40 ~ 50 parts of acryl resins, the azoisobutyronitrile of 0.5 ~ 10 part, benzoyl peroxides of 0.5 ~ 20 part, at 80 ~ 130 DEG C, form chitosan oligosaccharide bottom blended polymer after stirring reaction 20 ~ 24h, then form transparent cambered surface bottom through turning;
(5) count by weight, be 2 ~ 5 μm of natural earth pigments by the particle diameter of the acryl resin of 20 ~ 60 parts, the azoisobutyronitrile of 5 ~ 10 parts, the benzoyl peroxide of 15 ~ 30 parts and 20 ~ 40 parts, 10 ~ 60min is polymerized at 20 ~ 50 DEG C, obtain the polymer coating that viscosity is 8000 ~ 200000mPas, again the cambered surface bottom that step (4) is obtained is placed in die, the pattern being printed on dope layer is transferred to the iris district of bottom, intermediate primer layer;
(6) die is added after being polymerized by the material of bottom same composition, with the speed rotating cavity die of 400 ~ 1600r/min, and to its irradiation polymerization 2 ~ 20min, the top layer of preparing the most at last, intermediate primer layer and cambered surface bottom are under 0.02 ~ 0.04MPa pressure, and temperature is 120 ~ 150 DEG C and carries out compacting and can obtain a kind of chitosan oligosaccharide antimicrobial contact lenses.
Described irradiation polymerization device radiation dose rate is 5kGy/h, and irradiation dose is 400kGy.
Application process of the present invention: worn by the chitosan oligosaccharide antimicrobial contact lenses of preparation, A nearsighted person is wearing without any tingling sensation in process, and wears 8 ~ 10h also without dry and astringent situation, wears 1 ~ February eyes without red and swollen and inflammation symptom.
The present invention is compared with additive method, and Advantageous Effects is:
(1) the chitosan oligosaccharide antimicrobial contact lenses anti-microbial property prepared of the present invention is better, and after preventing for 1 ~ February, eyeglass bacterial number reduces by 90 ~ 95% than common eyeglass;
(2) adopt natural chitosan to prepare contact lenses, effectively match with human cornea, non-stimulated to human body.
Embodiment
By the acetate-sodium acetate buffer of solid-liquid mass ratio 1:5 by shitosan and 0.2mol/L, at 30 ~ 40 DEG C under 300 ~ 400r/min rotating speed, be uniformly mixed 20 ~ 50min, be mixed with the chitosan gum liquid solution that massfraction is 2%; The colloidal solution obtain preparation and enzymatic activity are the pectase of 1500 ~ 1800U/g, be uniformly mixed by the mass ratio of 20:1, and the ultrasonic assistant vibration under being placed in 80 ~ 100W, at 50 ~ 60 DEG C, 300 ~ 500r/min stirring at low speed, 3 ~ 5h, obtains enzymolysis colloidal solution; To be mixed complete after, continue to be heated to 90 ~ 95 DEG C to enzymolysis colloidal solution, go out after ferment treatment 10 ~ 15min, be placed in hydro-extractor, under 5000 ~ 6000r/min, high speed centrifugation is separated, and collects supernatant subsequently, and carries out suction filtration removal of impurities by the miillpore filter of 10 μm, collect filtered fluid and be placed in that Rotary Evaporators is concentrated into original volume 1/3, obtain chitosan oligosaccharide concentrate; Count by weight, choose the chitosan oligosaccharide concentrate of 20 ~ 59 parts of preparations, 40 ~ 50 parts of acryl resins, the azoisobutyronitrile of 0.5 ~ 10 part, benzoyl peroxides of 0.5 ~ 20 part, at 80 ~ 130 DEG C, form chitosan oligosaccharide bottom blended polymer after stirring reaction 20 ~ 24h, then form transparent cambered surface bottom through turning; Count by weight, be 2 ~ 5 μm of natural earth pigments by the particle diameter of the acryl resin of 20 ~ 60 parts, the azoisobutyronitrile of 5 ~ 10 parts, the benzoyl peroxide of 15 ~ 30 parts and 20 ~ 40 parts, 10 ~ 60min is polymerized at 20 ~ 50 DEG C, obtain the polymer coating that viscosity is 8000 ~ 200000mPas, again obtained cambered surface bottom is placed in die, the pattern being printed on dope layer is transferred to the iris district of bottom, intermediate primer layer; Die is added after being polymerized by the material of bottom same composition, with the speed rotating cavity die of 400 ~ 1600r/min, and to its irradiation polymerization 2 ~ 20min, the top layer of preparing the most at last, intermediate primer layer and cambered surface bottom are under 0.02 ~ 0.04MPa pressure, and temperature is 120 ~ 150 DEG C and carries out compacting and can obtain a kind of chitosan oligosaccharide antimicrobial contact lenses; Described irradiation polymerization device radiation dose rate is 5kGy/h, and irradiation dose is 400kGy;
Worn by the chitosan oligosaccharide antimicrobial contact lenses of preparation, A nearsighted person is wearing without any tingling sensation in process, and wears 8 ~ 10h also without dry and astringent situation, wears 1 ~ February eyes without red and swollen and inflammation symptom.
Example 1
By the acetate-sodium acetate buffer of solid-liquid mass ratio 1:5 by shitosan and 0.2mol/L, at 30 DEG C under 300r/min rotating speed, be uniformly mixed 20min, be mixed with the chitosan gum liquid solution that massfraction is 2%; The colloidal solution obtain preparation and enzymatic activity are the pectase of 1500U/g, are uniformly mixed by the mass ratio of 20:1, and the ultrasonic assistant vibration under being placed in 80W, at 50 DEG C, 300r/min stirring at low speed 3h, obtains enzymolysis colloidal solution; To be mixed complete after, continue to be heated to 90 DEG C to enzymolysis colloidal solution, go out after ferment treatment 10min, be placed in hydro-extractor, under 5000r/min, high speed centrifugation is separated, and collects supernatant subsequently, and carries out suction filtration removal of impurities by the miillpore filter of 10 μm, collect filtered fluid and be placed in that Rotary Evaporators is concentrated into original volume 1/3, obtain chitosan oligosaccharide concentrate; Count by weight, choose the chitosan oligosaccharide concentrate of 20 parts of preparations, 50 parts of acryl resins, the azoisobutyronitrile of 10 parts, benzoyl peroxides of 20 parts, at 80 DEG C, form chitosan oligosaccharide bottom blended polymer after stirring reaction 20h, then form transparent cambered surface bottom through turning; Count by weight, be 2 μm of natural earth pigments by the particle diameter of the acryl resin of 20 parts, the azoisobutyronitrile of 10 parts, the benzoyl peroxide of 30 parts and 40 parts, 10min is polymerized at 20 DEG C, obtain the polymer coating that viscosity is 8000mPas, again obtained cambered surface bottom is placed in die, the pattern being printed on dope layer is transferred to the iris district of bottom, intermediate primer layer; Die is added after being polymerized by the material of bottom same composition, with the speed rotating cavity die of 400r/min, and to its irradiation polymerization 2min, the top layer of preparing the most at last, intermediate primer layer and cambered surface bottom are under 0.02 ~ 0.04MPa pressure, and temperature is 120 ~ 150 DEG C and carries out compacting and can obtain a kind of chitosan oligosaccharide antimicrobial contact lenses; Chitosan oligosaccharide antimicrobial contact lenses anti-microbial property prepared by the present invention is better, and after preventing January, eyeglass bacterial number reduces by 90% than common eyeglass, adopts natural chitosan to prepare contact lenses simultaneously, effectively matches with human cornea, non-stimulated to human body.
Example 2
By the acetate-sodium acetate buffer of solid-liquid mass ratio 1:5 by shitosan and 0.2mol/L, at 35 DEG C under 350r/min rotating speed, be uniformly mixed 35min, be mixed with the chitosan gum liquid solution that massfraction is 2%; The colloidal solution obtain preparation and enzymatic activity are the pectase of 1650U/g, are uniformly mixed by the mass ratio of 20:1, and the ultrasonic assistant vibration under being placed in 90W, at 55 DEG C, 400r/min stirring at low speed 4h, obtains enzymolysis colloidal solution; To be mixed complete after, continue to be heated to 93 DEG C to enzymolysis colloidal solution, go out after ferment treatment 12min, be placed in hydro-extractor, under 5500r/min, high speed centrifugation is separated, and collects supernatant subsequently, and carries out suction filtration removal of impurities by the miillpore filter of 10 μm, collect filtered fluid and be placed in that Rotary Evaporators is concentrated into original volume 1/3, obtain chitosan oligosaccharide concentrate; Count by weight, choose the chitosan oligosaccharide concentrate of 40 parts of preparations, 45 parts of acryl resins, the azoisobutyronitrile of 5 parts, benzoyl peroxides of 10 parts, at 100 DEG C, form chitosan oligosaccharide bottom blended polymer after stirring reaction 21h, then form transparent cambered surface bottom through turning; Count by weight, be 4 μm of natural earth pigments by the particle diameter of the acryl resin of 35 parts, the azoisobutyronitrile of 8 parts, the benzoyl peroxide of 17 parts and 40 parts, 45min is polymerized at 35 DEG C, obtain the polymer coating that viscosity is 120000mPas, again obtained cambered surface bottom is placed in die, the pattern being printed on dope layer is transferred to the iris district of bottom, intermediate primer layer; Die is added after being polymerized by the material of bottom same composition, with the speed rotating cavity die of 800r/min, and to its irradiation polymerization 15min, the top layer of preparing the most at last, intermediate primer layer and cambered surface bottom are under 0.02 ~ 0.04MPa pressure, and temperature is 120 ~ 150 DEG C and carries out compacting and can obtain a kind of chitosan oligosaccharide antimicrobial contact lenses; Chitosan oligosaccharide antimicrobial contact lenses anti-microbial property prepared by the present invention is better, and after preventing February, eyeglass bacterial number reduces by 93% than common eyeglass, adopts natural chitosan to prepare contact lenses simultaneously, effectively matches with human cornea, non-stimulated to human body.
Example 3
By the acetate-sodium acetate buffer of solid-liquid mass ratio 1:5 by shitosan and 0.2mol/L, at 40 DEG C under 400r/min rotating speed, be uniformly mixed 50min, be mixed with the chitosan gum liquid solution that massfraction is 2%; The colloidal solution obtain preparation and enzymatic activity are the pectase of 1800U/g, are uniformly mixed by the mass ratio of 20:1, and the ultrasonic assistant vibration under being placed in 100W, at 60 DEG C, 500r/min stirring at low speed 5h, obtains enzymolysis colloidal solution; To be mixed complete after, continue to be heated to 95 DEG C to enzymolysis colloidal solution, go out after ferment treatment 15min, be placed in hydro-extractor, under 6000r/min, high speed centrifugation is separated, and collects supernatant subsequently, and carries out suction filtration removal of impurities by the miillpore filter of 10 μm, collect filtered fluid and be placed in that Rotary Evaporators is concentrated into original volume 1/3, obtain chitosan oligosaccharide concentrate; Count by weight, choose the chitosan oligosaccharide concentrate of 59 parts of preparations, 40 parts of acryl resins, the azoisobutyronitrile of 0.5 part, benzoyl peroxides of 0.5 part, at 130 DEG C, form chitosan oligosaccharide bottom blended polymer after stirring reaction 24h, then form transparent cambered surface bottom through turning; Count by weight, be 5 μm of natural earth pigments by the particle diameter of the acryl resin of 60 parts, the azoisobutyronitrile of 5 parts, the benzoyl peroxide of 15 parts and 20 parts, 60min is polymerized at 50 DEG C, obtain the polymer coating that viscosity is 200000mPas, again obtained cambered surface bottom is placed in die, the pattern being printed on dope layer is transferred to the iris district of bottom, intermediate primer layer; Die is added after being polymerized by the material of bottom same composition, with the speed rotating cavity die of 1600r/min, and to its irradiation polymerization 20min, the top layer of preparing the most at last, intermediate primer layer and cambered surface bottom are under 0.02 ~ 0.04MPa pressure, and temperature is 120 ~ 150 DEG C and carries out compacting and can obtain a kind of chitosan oligosaccharide antimicrobial contact lenses; Chitosan oligosaccharide antimicrobial contact lenses anti-microbial property prepared by the present invention is better, and after preventing February, eyeglass bacterial number reduces by 95% than common eyeglass, adopts natural chitosan to prepare contact lenses simultaneously, effectively matches with human cornea, non-stimulated to human body.
Claims (2)
1. a preparation method for chitosan oligosaccharide antimicrobial contact lenses, is characterized in that concrete preparation process is:
(1) by the acetate-sodium acetate buffer of solid-liquid mass ratio 1:5 by shitosan and 0.2mol/L, at 30 ~ 40 DEG C under 300 ~ 400r/min rotating speed, be uniformly mixed 20 ~ 50min, be mixed with the chitosan gum liquid solution that massfraction is 2%;
(2) colloidal solution preparation obtained and enzymatic activity are the pectase of 1500 ~ 1800U/g, be uniformly mixed by the mass ratio of 20:1, and the ultrasonic assistant vibration under being placed in 80 ~ 100W, at 50 ~ 60 DEG C, 300 ~ 500r/min stirring at low speed, 3 ~ 5h, obtains enzymolysis colloidal solution;
(3) to be mixed complete after, continue to be heated to 90 ~ 95 DEG C to enzymolysis colloidal solution, go out after ferment treatment 10 ~ 15min, be placed in hydro-extractor, under 5000 ~ 6000r/min, high speed centrifugation is separated, and collects supernatant subsequently, and carries out suction filtration removal of impurities by the miillpore filter of 10 μm, collect filtered fluid and be placed in that Rotary Evaporators is concentrated into original volume 1/3, obtain chitosan oligosaccharide concentrate;
(4) count by weight, choose the chitosan oligosaccharide concentrate of 20 ~ 59 parts of preparations, 40 ~ 50 parts of acryl resins, the azoisobutyronitrile of 0.5 ~ 10 part, benzoyl peroxides of 0.5 ~ 20 part, at 80 ~ 130 DEG C, form chitosan oligosaccharide bottom blended polymer after stirring reaction 20 ~ 24h, then form transparent cambered surface bottom through turning;
(5) count by weight, be 2 ~ 5 μm of natural earth pigments by the particle diameter of the acryl resin of 20 ~ 60 parts, the azoisobutyronitrile of 5 ~ 10 parts, the benzoyl peroxide of 15 ~ 30 parts and 20 ~ 40 parts, 10 ~ 60min is polymerized at 20 ~ 50 DEG C, obtain the polymer coating that viscosity is 8000 ~ 200000mPas, again the cambered surface bottom that step (4) is obtained is placed in die, the pattern being printed on dope layer is transferred to the iris district of bottom, intermediate primer layer;
(6) die is added after being polymerized by the material of bottom same composition, with the speed rotating cavity die of 400 ~ 1600r/min, and to its irradiation polymerization 2 ~ 20min, the top layer of preparing the most at last, intermediate primer layer and cambered surface bottom are under 0.02 ~ 0.04MPa pressure, and temperature is 120 ~ 150 DEG C and carries out compacting and can obtain a kind of chitosan oligosaccharide antimicrobial contact lenses.
2. the preparation method of a kind of chitosan oligosaccharide antimicrobial contact lenses according to claims 1, is characterized in that: described irradiation polymerization device radiation dose rate is 5kGy/h, and irradiation dose is 400kGy.
Priority Applications (1)
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| CN201510620699.6A CN105137613A (en) | 2015-09-27 | 2015-09-27 | Preparation method of chitosan oligosaccharide antibacterial contact lenses |
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| CN201510620699.6A CN105137613A (en) | 2015-09-27 | 2015-09-27 | Preparation method of chitosan oligosaccharide antibacterial contact lenses |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005036236A2 (en) * | 2003-10-06 | 2005-04-21 | Praful Doshi | Tinted lenses and methods of manufacture |
| CN101971057A (en) * | 2008-03-18 | 2011-02-09 | 诺瓦提斯公司 | Coating process for ophthalmic lenses |
-
2015
- 2015-09-27 CN CN201510620699.6A patent/CN105137613A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005036236A2 (en) * | 2003-10-06 | 2005-04-21 | Praful Doshi | Tinted lenses and methods of manufacture |
| CN101971057A (en) * | 2008-03-18 | 2011-02-09 | 诺瓦提斯公司 | Coating process for ophthalmic lenses |
Non-Patent Citations (6)
| Title |
|---|
| 候春林: "《几丁质与医学》", 28 February 2001 * |
| 张军林: "《简明生物化学》", 30 June 2014 * |
| 朱婉萍: "《甲壳素及其衍生物的研究与应用》", 30 November 2014 * |
| 王振伟: "《超声波辅助酶法制备壳寡糖及抗氧化活性研究》", 《中国食品添加剂试验研究》 * |
| 董炎明: "《甲壳素化学及应用》", 《大学化学》 * |
| 黎厚斌: "《包装应用化学》", 31 January 2014 * |
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