CN105126243A - Microneedle injection bullet, manufacturing method thereof and mirconeedle injection device - Google Patents
Microneedle injection bullet, manufacturing method thereof and mirconeedle injection device Download PDFInfo
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- CN105126243A CN105126243A CN201510556515.4A CN201510556515A CN105126243A CN 105126243 A CN105126243 A CN 105126243A CN 201510556515 A CN201510556515 A CN 201510556515A CN 105126243 A CN105126243 A CN 105126243A
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- microneedle
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0053—Methods for producing microneedles
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- General Health & Medical Sciences (AREA)
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- Media Introduction/Drainage Providing Device (AREA)
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- Biomedical Technology (AREA)
Abstract
The invention relates to the technical field of microneedle injection of cutaneous penetration, in particular to a microneedle injection bullet, a manufacturing method thereof and a microneedle injection device. The microneedle injection bullet comprises a microneedle array thin film and a substrate. The microneedle array thin film comprises a thin film substrate and a microneedle array on the front face of the thin film substrate. The substrate is provided with a through hole array aligned to the microneedle array. The thin film substrate of the microneedle array thin film is fixed to the substrate. Each microneedle of the microneedle array is embedded into a through hole of the through hole array. The microneedle injection device matched with the microneedle injection bullet comprises the microneedle injection bullet and a microneedle propelling device. The microneedle propelling device separates the microneedles of the microneedle array from the microneedle array thin film and presses the microneedles into skin. The microneedle injection device has the advantages that when the microneedle injection bullet is used for injection, and the microneedles are separated from the microneedle array thin film, so that the microneedles completely enter the skin, medicine contained in the microneedles is completely dissolved and released, and the purpose of precisely controlling the microneedle administration dosage is achieved.
Description
Technical field
The present invention relates to microneedle injection bullet of the microneedle injection technical field of transdermal administration, particularly a kind of transdermal administration and preparation method thereof and microneedle injection equipment.
Background technology
Transdermal administration refers at drugs through skin surface administration.Medicine, through the barrier of skin layers, enters body circulation through capillary absorbance and produces whole body or local therapeutic effects.It is same class medication administration method that this Transdermal delivery systems inputs administration with subcutaneous injection or vein in principle, but has more painless compared with conventional injection administering mode, safer, stable and advantage that patient compliance is good.In transdermal administration technology, medicine relies on the Concentraton gradient of medicine as driving force, and diffusion enters blood flow through skin and produces drug effect, and diffusion rate depends on size through cuticular Concentraton gradient and drug molecule and hydrophilic.But because skin is very low to the permeability of most drug, the medicine that effectively can be passed skin performance drug effect by Passive diffusion is little.For promoting drug transdermal permeability, people start to adopt mechanical means to make keratodermatitis produce micropore and break.Wherein microneedle cutaneous technology is proved to be the most effective transdermal administration based on mechanical means.The dual release advantage of microneedle cutaneous combine with technique subcutaneous injection and percutaneous plaster, the micropore wound that skin causes skin minimum degree is acted on by a kind of device with many microspikes, medicine passes through the permeability that created micropore can increase medicine, and very large facilitation is played in the infiltration particularly for macromolecular drug.When using soluble Biodegradable material to make micropin, medicine and biomolecule can be mixed in micropin itself.In application process, so there is not the refuse of band tip in soluble microneedle configuration rapid solution in skin, thus release medicine and biomolecule.
The method that solubilized micropin penetrates skin has two kinds at present usually, and one is that hands is patted and penetrated, and a kind of is automatic needle inserter based on spring, the automatic blood sampler used when being similar to finger tip blood sampling.With hands pat disadvantage micropin being penetrated skin be everyone use time dynamics different, cause the degree of depth penetrated to have significant difference, even same person, also depth of needle can be caused different because each dynamics of pricking is variant.Although this needle inserter automatic based on spring can improve the repeatability of inserting needle, or the difference brought because skin is different can not be solved.Due to the paster substrate of ining succession of paster micropin, the microneedle drug of a part rests on skin surface along with the substrate of paster, not by human body solution absorption, due to the difference of individual's skin thickness and skin elasticity, that stays skin surface during use can not be different by the ratio of the first half in the micropin needle body that dissolves, can absorbed micropin dose be different when causing per injection, so be difficult to the dosage accurately controlling micropin.
Summary of the invention
Technical problem to be solved by this invention is: in existing microneedle cutaneous technology, is difficult to dosage when accurately controlling injection.
The technical solution adopted for the present invention to solve the technical problems is: a kind of microneedle injection bullet, comprise microneedle array thin film and substrate, microneedle array thin film comprises the microneedle array in film substrate and film substrate front, substrate has the through hole array with microneedle array alignment, the film substrate of microneedle array thin film is fixed on substrate, and each micropin of microneedle array embeds the through hole of through hole array.
Further restriction, this microneedle injection bullet also comprises cover plate, cover plate is positioned at the back side of microneedle array thin film, cover plate is connected with substrate, form the shell of microneedle array thin film, microneedle array thin film is sandwiched between cover plate and substrate, cover plate has the through hole array alignd with the through hole array on substrate.
Further restriction, cover plate has syndeton, and microneedle injection bullet is arranged on the injection port place at micropin propulsion plant by the syndeton on cover plate.
Further restriction, the micropin of microneedle array thin film is solubilized micropin, in micropin, have active agents.Solubilized micropin comprises at least one soluble polymeric thing, the optional self-induced transparency matter acid of soluble polymeric thing, fibroin albumen, collagen protein, gelatin, hydrogel, carboxymethyl cellulose, hydroxypropyl emthylcellulose, chondroitin sulfate, glycogen, dextrin, amylose, chondroitin sulfate, polylactic-co-glycolic acid, Poly(D,L-lactide-co-glycolide, PVOH ester, polyvinyl alcohol, polyacrylic acid, polypropylene, Merlon, polystyrene, polyethylene, polrvinyl chloride, ABS plastic (acrylonitrile-butadiene-styrene copolymer), polydimethylsiloxane, Kynoar, acetate fiber, polyester, polyurethane, poly-dioxy ring ethyl ketone, PEG, polylactic acid, polyacrylamide polymer, cyclic olefin copolymer, carboxymethyl chitosan, Poly-L-lactic acid, alginic acid, glucosan, dextran sulfate, hydroxypropyl emthylcellulose, chitin, polyvinylpyrrolidone, lactose, galactose, trehalose, sucrose, maltose, glucosan, glucosides, fructose, chitosan, agarose, Sorbitol, mannitol or xylitol, Dan Baiduotang proteoglycan PG, phosphatidylcholine, polylactide, PGA, hydroxypropyl cellulose, wax, polyester, polyanhydride, polyamide, phosphorus based polymer, poly-(cyanoacrylate), polyurethane, poe, poly-dihydropyran, polyacetals, Biodegradable polymeric, polypeptide, the combination in any of a kind of or above-mentioned polymer in carbohydrate.There is at least one active agents in micropin, active agents can be medicine or non-therapeutic medicine, as cosmetics molecule, active agents can be selected from citric acid, protein, peptide, polysaccharide, antigen, immunogen, vaccine, antibody, enzyme, nucleic acid, aptamer, virus, antibacterial, cell, hormone, antibiotic, cancer therapy drug, genetically engineered drug, natural product medicine, Chinese medicine ingredients, nutritional labeling, therapeutic agent, diagnostic agent, and the combination of mentioned reagent.
With the microneedle injection equipment that above-mentioned microneedle injection bullet is supporting, comprise microneedle injection bullet and micropin propulsion plant, micropin propulsion plant is by each micropin of microneedle array and microneedle array thin film separation and be pressed into skin.
Further restriction, microneedle injection bullet is arranged on the injection port of micropin propulsion plant, micropin propulsion plant is the micropin propulsion plant based on gases at high pressure, based on gases at high pressure the back side from micropin propulsion plant to microneedle injection bullet apply gases at high pressure, promote micropin by gases at high pressure and depart from microneedle array thin film, press-in skin.Or micropin propulsion plant is the micropin propulsion plant based on micro-lance, the micropin propulsion plant based on micro-lance inserts micro-lance array to the back side of microneedle injection bullet, promotes micropin depart from microneedle array thin film by micro-lance of micro-lance array, press-in skin.
Wherein, micropin propulsion plant based on gases at high pressure has injecting cavity, high pressure chest, high-pressure air source, valve train, air valve knocking gear and cocking mechanism, high-pressure air source passes into gases at high pressure to high pressure chest, high pressure chest is communicated by valve train with injecting cavity, cocking mechanism controls the needle that air valve knocking gear hits valve train, valve train is opened fast, the front opening of injecting cavity, this opening is as injection port, microneedle injection bullet is arranged on this opening part, the gases at high pressure entering injecting cavity promote micropin and depart from microneedle array thin film, press-in skin.
Further restriction, micropin propulsion plant is pistol shape, injecting cavity, high pressure chest, the gentle valve jacket mechanism of valve train is positioned at the body of a gun part of micropin propulsion plant, injecting cavity, high pressure chest, the gentle valve jacket mechanism of valve train is arranged in order along the length direction of body of a gun part, injecting cavity is positioned at body of a gun part foremost, valve train comprises valve opening and air valve needle, valve opening communicates with high pressure chest, in valve opening, there is air vent, air vent is communicated with injecting cavity by aerofluxus gas circuit, air valve needle is arranged in valve opening movably linearly, have between air valve needle and valve opening and be sealed and matched, valve opening is exposed in the rear end of air valve needle, air valve needle is opened between air valve needle and valve opening by the mode moved forward and is sealed and matched, the high pressure gas in high pressure chest is made to enter injecting cavity by air vent and aerofluxus gas circuit, air valve needle moves forward into horizontal reset backward by spring, keep the state that is sealed and matched between air valve needle and valve opening, air valve knocking gear comprises impact block and propelling spring, cocking mechanism release impact block, make impact block under the promotion of propelling spring, hit the rear end of the needle of valve train.
Wherein, micropin propulsion plant based on micro-lance comprises the micro-lance array on elastic outer cover, micro-lance substrate and micro-lance substrate one side end face, micro-lance array aligns with the microneedle array of microneedle injection bullet, the opposite side end face of micro-lance substrate is connected with elastic outer cover, the opening of elastic outer cover is as injection port, and microneedle injection bullet is arranged on the opening part of elastic outer cover, micro-lance array press-in microneedle injection bullet, and promote micropin disengaging microneedle array thin film, press-in skin.
Further restriction, microneedle injection bullet also comprises cover plate, cover plate is positioned at the back side of microneedle array thin film, cover plate is connected with substrate, form the shell of microneedle array thin film, microneedle array thin film is sandwiched between cover plate and substrate, cover plate has the through hole array alignd with the through hole array on substrate, and cover plate or substrate have the guide frame led to the lifting moving of micro-lance substrate.
A preparation method for above-mentioned microneedle injection bullet, step specific as follows:
A, in micropin female mold, fill up micropin body pre-polymer solution and solidify, obtained microneedle array thin film;
The back side of the film substrate of microneedle array thin film is after hardening pasted in B, transfer base substrate pressing surface with pressure sensitive adhesive, for being glued by microneedle array thin film, departs from former;
C, utilize transfer base substrate by microneedle array film transfer to substrate, and alignd with through hole array by microneedle array, make micropin be embedded in the through hole of substrate, the end face of substrate scribbles viscose glue, and microneedle array thin film is fixed by viscose glue and substrate bonding;
D, pressure sensitive adhesive and microneedle array thin film to be departed from, obtain microneedle injection bullet according to claim 1.
There is a preparation method for the microneedle injection bullet of cover plate, step specific as follows:
A, in micropin female mold, fill up micropin body pre-polymer solution and solidify, obtained microneedle array thin film;
The back side of the film substrate of microneedle array thin film is after hardening pasted in B, transfer base substrate pressing surface with pressure sensitive adhesive, for being glued by microneedle array thin film, departs from former;
C, utilize transfer base substrate by microneedle array film transfer to substrate, and alignd with through hole array by microneedle array, make micropin be embedded in the through hole of substrate, the end face of substrate scribbles viscose glue, and microneedle array thin film is fixed by viscose glue and substrate bonding;
D, pressure sensitive adhesive and microneedle array thin film to be departed from, obtain microneedle injection bullet according to claim 1;
E, cover at the back side of microneedle array thin film by cover plate, the through hole array of cover plate and the through hole array of substrate are alignd by position mark simultaneously.
The invention has the beneficial effects as follows: when utilizing microneedle injection bullet to inject, by by micropin and microneedle array thin film separation, make micropin enter skin completely, the medicine that micropin comprises is completely dissolved release, reaches the object accurately controlling micropin dosage.
Accompanying drawing explanation
Below in conjunction with drawings and Examples, the present invention is further described;
Fig. 1 is the preparation process schematic diagram of the microneedle injection bullet of embodiments of the invention 1;
Fig. 2 is the structural representation of the microneedle injection bullet of embodiments of the invention 2;
Fig. 3 is the electromicroscopic photograph schematic diagram preparing the master mold mould of micropin female mold of the present invention;
Fig. 4 is the electromicroscopic photograph schematic diagram of micropin female mold of the present invention;
Fig. 5 is the single unit system schematic diagram based on the microneedle injection equipment of gases at high pressure in embodiments of the invention 3;
Fig. 6 is the single unit system schematic diagram based on the microneedle injection equipment of micro-lance in embodiments of the invention 4;
Fig. 7 is the process chart one based on the microneedle injection equipment of micro-lance in embodiments of the invention 4;
Fig. 8 is the process chart two based on the microneedle injection equipment of micro-lance in embodiments of the invention 4;
In figure, 1. microneedle array thin film, 2. substrate, 3. micropin female mold, 4. transfer base substrate, 5. viscose glue, 6. cover plate, 61. syndetons, 62. leads, 7. injecting cavity, 8. high pressure chest, 9. gascollecting cap cylinder, 10. air valve needle, 11. impact blocks, 12. propelling springs, 13. cocking mechanisms, 14. safety-valves, 15. elastic outer cover, 16. micro-lance substrates
Detailed description of the invention
Embodiment 1:
As shown in Figure 1, a kind of microneedle injection bullet, comprise microneedle array thin film 1 and substrate 2, microneedle array thin film 1 comprises the microneedle array in film substrate and film substrate front, substrate 2 has the through hole array with microneedle array alignment, the film substrate of microneedle array thin film 1 is fixing on a substrate 2, and each micropin of microneedle array embeds the through hole of through hole array.
The micropin of microneedle array thin film 1 is solubilized micropin, and solubilized micropin comprises at least one soluble polymeric thing, and soluble polymeric thing can be selected from fibroin albumen, collagen protein, gelatin, hydrogel, carboxymethyl cellulose, hydroxypropyl emthylcellulose, chondroitin sulfate, glycogen, dextrin, amylose, hyaluronic acid, chondroitin sulfate, polylactic-co-glycolic acid, Poly(D,L-lactide-co-glycolide, PVOH ester, polyvinyl alcohol, polyacrylic acid, polypropylene, Merlon, polystyrene, polyethylene, polrvinyl chloride, ABS plastic (acrylonitrile-butadiene-styrene copolymer), polydimethylsiloxane, Kynoar, acetate fiber, polyester, polyurethane, poly-dioxy ring ethyl ketone, PEG, polylactic acid, polyacrylamide polymer, cyclic olefin copolymer, carboxymethyl chitosan, Poly-L-lactic acid, alginic acid, glucosan, dextran sulfate, hydroxypropyl emthylcellulose, chitin, polyvinylpyrrolidone, lactose, galactose, trehalose, sucrose, maltose, glucosan, glucosides, fructose, chitosan, agarose, Sorbitol, mannitol or xylitol, Dan Baiduotang proteoglycan PG, phosphatidylcholine, polylactide, PGA, hydroxypropyl cellulose, wax, polyester, polyanhydride, polyamide, phosphorus based polymer, poly-(cyanoacrylate), polyurethane, poe, poly-dihydropyran, polyacetals, Biodegradable polymeric, polypeptide, the combination in any of a kind of or above-mentioned polymer in carbohydrate.
There is at least one active agents in micropin, active agents can be medicine or non-therapeutic medicine, as cosmetics molecule, active agents can be selected from citric acid, protein, peptide, polysaccharide, antigen, immunogen, vaccine, antibody, enzyme, nucleic acid, aptamer, virus, antibacterial, cell, hormone, antibiotic, cancer therapy drug, genetically engineered drug, natural product medicine, Chinese medicine ingredients, nutritional labeling, therapeutic agent, diagnostic agent, and the combination of mentioned reagent.
The preparation method of this microneedle injection bullet, step specific as follows:
A, in the micropin groove of micropin female mold 3 in fill up micropin body pre-polymer solution and solidify, obtained microneedle array thin film 1;
Wherein, micropin body pre-polymer solution can be the hyaluronic acid containing 5%, Hepatitis B virus vaccine and be applicable to the water-soluble polymers of adjuvant (Th1 type adjuvant) of vaccine.This steps A is specific as follows: first prepare micropin female mold 3; Then being covered by micropin body pre-polymer solution has in the micropin female mold 3 of needle tray; Place the bubble removed completely for 20 minutes in needle tray in a vacuum, make micropin body pre-polymer solution enter into described needle tray, reclaim the micropin body pre-polymer solution of micropin female mold 3 surface residual; The female mold adding micropin body pre-polymer solution is positioned over dry solidification in the dry environment of 4 DEG C ~ 20 DEG C, obtains microneedle array thin film 1.
Micropin female mold 3 is prepared by following preparation process,
1, prepare master mold mould, there is the micropin of 400 (20X20 is capable) tetrahedroids on the surface of master mold mould, the height of micropin about 500 microns, bottom diameter about 300 microns.(aciculiform as shown in Figure 3);
2, the mixture getting prepolymerized polydimethylsiloxane 50 grams and cross-linking agent 5 grams is poured on master mold mould, place 60 minutes at temperature is 90 DEG C, by the polydimethylsiloxane after solidification and master mold mould separating, reversion female mold, obtains the female mold (as shown in Figure 4) that surface has the needle tray suitable with micropin on master mold mould;
The back side of the film substrate of microneedle array thin film 1 is after hardening pasted in B, transfer base substrate 4 pressing surface with pressure sensitive adhesive, for being glued by microneedle array thin film 1, departs from former;
The preparation method that surface has the transfer base substrate 4 of pressure sensitive adhesive is as follows:
First prepare a kind of pressure sensitive adhesive, this pressure sensitive adhesive is mixed with containing the multiple formulation soln provided by Dow corning company and forms.Be the ratio mix and blend 5 hours of 7:3:10 according to mass ratio by DOW CORNING 7646 viscose glues/DOW CORNING 7652 viscose glues/toluene solvant;
Then, each in the mixed liquor after stirring is that 1:200 adds DOW CORNING SYL-OFFSL7028 cross-linking agent and DOW CORNING SYL-OFFSL9250anchorage additive in mass ratio;
Subsequently, more in mass ratio for 1:200 adds DOW CORNING SYL-OFF4000 catalyst in the mixed solution of joining, stirring one hour is continued;
Finally, the pressure sensitive adhesive solution of joining is spun on the substrate 2 of PET material with 3000 (revolutions per second) rotating speed, spin coating there is the transfer base substrate 4 of pressure sensitive adhesive solution to be placed in the baking oven of 150 DEG C to dry 1 minute, be prepared into the transfer base substrate 4 that surface has pressure sensitive adhesive.
C, utilize transfer base substrate 4 that microneedle array thin film 1 is transferred to substrate 2, substrate 2 thickness is 0.6mm, and microneedle array is alignd with through hole array, micropin is made to be embedded in the through hole of substrate 2, the end face of substrate 2 scribbles viscose glue 5, and microneedle array thin film 1 bonds fixing by viscose glue 5 and the end face of substrate 2;
D, pressure sensitive adhesive and microneedle array thin film 1 to be departed from.
Embodiment 2:
As shown in Figure 2, a kind of microneedle injection bullet, compare with embodiment 1, this microneedle injection bullet also comprises cover plate 6, cover plate 6 is positioned at the back side of microneedle array thin film 1, cover plate 6 is connected with substrate 2, form the shell of microneedle array thin film 1, the connected mode of cover plate 6 and substrate 2 is for being threaded or dovetail groove clamping, microneedle array thin film 1 is sandwiched between cover plate 6 and substrate 2, cover plate 6 has the through hole array alignd with the through hole array on substrate 2, cover plate 6 is the same with each through hole size of the through hole array of substrate 2, merge after the through hole array consistency from top to bottom of cover plate 6 and substrate 2 and become cylinder array, as sandwich, a micropin is accompanied in each cylinder of cylinder array.
Cover plate 6 has syndeton 61, microneedle injection bullet is arranged on the injection port place at micropin propulsion plant by the syndeton 61 on cover plate 6.
The preparation method of this microneedle injection bullet, step specific as follows:
A, in the micropin groove of micropin female mold 3 in fill up micropin body pre-polymer solution and solidify, obtained microneedle array thin film 1; Micropin body pre-polymer solution can be formed by the hyaluronic configuration of different molecular weight, by molecular weight be the hyaluronic acid dissolves of the hyaluronan molecule amount of the mixing of 80K ~ 800KDa in deionized water, the hyaluronic mass fraction of solution is 20%, then 8wt% vitamin C is joined the hyaluronic configuration being mixed with different molecular weight, other hyaluronic preparations being mixed with different molecular weight being added with active component can refer to embodiment.
The back side of the film substrate of microneedle array thin film 1 is after hardening pasted in B, transfer base substrate 4 pressing surface with pressure sensitive adhesive, for being glued by microneedle array thin film 1, departs from former;
C, utilize transfer base substrate 4 that microneedle array thin film 1 is transferred to substrate 2, and microneedle array is alignd with through hole array, make micropin be embedded in the through hole of substrate 2, the end face of substrate 2 scribbles viscose glue 5, and microneedle array thin film 1 bonds fixing by viscose glue 5 and the end face of substrate 2;
D, pressure sensitive adhesive and microneedle array thin film 1 to be departed from;
E, cover at the back side of microneedle array thin film 1 by cover plate 6, the through hole array of cover plate 6 and the through hole array of substrate 2 are alignd by position mark simultaneously.
Embodiment 3:
A kind of microneedle injection equipment, comprise microneedle injection bullet and the micropin propulsion plant of embodiment 1 and embodiment 2, microneedle injection bullet is arranged on the injection port of micropin propulsion plant, micropin propulsion plant is the micropin propulsion plant based on gases at high pressure, based on gases at high pressure the back side from micropin propulsion plant to microneedle injection bullet apply gases at high pressure, promote micropin by gases at high pressure and depart from microneedle array thin film 1, press-in skin, pass completely through biological barrier, such as skin, tissue or cell membrane, micropin after entering starts to dissolve the medicine wrapped up, medicine enters skin degraded and absorbed completely, thus reach the object of the dosage accurately controlling micropin.
As shown in Figure 5, injecting cavity 7 should be had based on the micropin propulsion plant of gases at high pressure, high pressure chest 8, high-pressure air source, valve train, air valve knocking gear and cocking mechanism 13, high-pressure air source passes into gases at high pressure to high pressure chest 8, high pressure chest 8 is communicated by valve train with injecting cavity 7, cocking mechanism 13 controls the needle that air valve knocking gear hits valve train, valve train is opened fast, the front opening of injecting cavity 7, this opening is as injection port, microneedle injection bullet is arranged on this opening part, the gases at high pressure entering injecting cavity 7 promote micropin and depart from microneedle array thin film 1, press-in skin.The syndeton 61 of the cover plate 6 of the microneedle injection bullet in this accompanying drawing is the corrugated tubing of the rear end of cover plate 6, and corrugated tubing has external screw thread, and microneedle injection bullet is connected with the open-top screw thread of injecting cavity 7 by this external screw thread.
Micropin propulsion plant is pistol shape, the gentle valve jacket mechanism of injecting cavity 7, high pressure chest 8, valve train is positioned at the body of a gun part of micropin propulsion plant, the gentle valve jacket mechanism of injecting cavity 7, high pressure chest 8, valve train is arranged in order along the length direction of body of a gun part, and injecting cavity 7 is positioned at body of a gun part foremost.
Valve train comprises valve opening and air valve needle 10, valve opening communicates with high pressure chest 8, in valve opening, there is air vent, air vent is communicated with injecting cavity 7 by aerofluxus gas circuit, air valve needle 10 is arranged in valve opening movably linearly, have between air valve needle 10 and valve opening and be sealed and matched, valve opening is exposed in the rear end of air valve needle 10, air valve needle 10 is opened between air valve needle 10 and valve opening by the mode moved forward and is sealed and matched, the high pressure gas in high pressure chest 8 is made to enter injecting cavity 7 by air vent and aerofluxus gas circuit, air valve needle 10 moves forward into horizontal reset backward by spring, keep the state that is sealed and matched between air valve needle 10 and valve opening.
Air valve knocking gear comprises impact block 11 and propelling spring 12, and cocking mechanism 13 discharges impact block 11, makes impact block 11 under the promotion of propelling spring 12, hit the rear end of the needle of valve train.
High-pressure air source is the gascollecting cap cylinder 9 of in-built liquefied carbon dioxide.The gascollecting cap cylinder 9 of liquefied carbon dioxide is connected with high pressure chest 8 by screw thread, and connecting place has a safety-valve 14.
When preparing the micropin launching microneedle injection bullet, open the safety-valve 14 of gascollecting cap cylinder 9, gases at high pressure are filled high pressure chest 8 by gascollecting cap cylinder 9, the trigger of cocking mechanism 13 is detained, release impact block 11, propelling spring 12 impact block 11 compressed clashes into air valve needle 10, air valve needle 10 is knocked forward slip, open between air valve needle 10 and valve opening and be sealed and matched, gases at high pressure enter injecting cavity 7 by air vent and aerofluxus gas circuit, the gases at high pressure poured instantaneously promote micropin and depart from microneedle array thin film 1, micropin penetrates, submerge skin completely, dissolve the active agents discharging and be wrapped in inside micropin.
Embodiment 4:
Micropin propulsion plant is the micropin propulsion plant based on micro-lance, and the micropin propulsion plant based on micro-lance inserts micro-lance array to the back side of microneedle injection bullet, promotes micropin depart from microneedle array thin film 1 by micro-lance of micro-lance array, press-in skin.
As Fig. 6, shown in 7 and 8, micropin propulsion plant based on micro-lance comprises elastic outer cover 15, micro-lance array on micro-lance substrate 16 and micro-lance substrate 16 1 side end face, elastic outer cover 15 is in dome-shaped, micro-lance of micro-lance array is micron-sized cylinder, diameter is 500 microns, micro-lance array aligns with the microneedle array of microneedle injection bullet, a micropin bullet be clipped in cylinder array aimed at by the micro-lance of every root, the opposite side end face of micro-lance substrate 16 is connected with elastic outer cover 15, the opening of elastic outer cover 15 is as injection port, microneedle injection bullet is arranged on the opening part of elastic outer cover 15, micro-lance array press-in microneedle injection bullet, and promote micropin disengaging microneedle array thin film 1, press-in skin.
Microneedle injection bullet also comprises cover plate 6, cover plate 6 is positioned at the back side of microneedle array thin film 1, cover plate 6 is connected with substrate 2, form the shell of microneedle array thin film 1, microneedle array thin film 1 is sandwiched between cover plate 6 and substrate 2, cover plate 6 has the through hole array alignd with the through hole array on substrate 2, described cover plate 6 or substrate 2 have the guide frame led to the lifting moving of micro-lance substrate 16.In the figure, guide frame is lead 62.
Press with finger elastic outer cover 15, elastic outer cover 15 can by micro-lance array pressure, micro-lance array press-in microneedle injection bullet, and promote micropin disengaging microneedle array thin film 1, press-in skin, elastic outer cover 15 is restored subsequently from deformation, drives micro-lance array to leave skin and is returned to original position, micropin stays in the body, and dissolves release and is wrapped in interior active agents.
Claims (12)
1. a microneedle injection bullet, it is characterized in that: comprise microneedle array thin film and substrate, microneedle array thin film comprises the microneedle array in film substrate and film substrate front, substrate has the through hole array with microneedle array alignment, the film substrate of microneedle array thin film is fixed on substrate, and each micropin of microneedle array embeds the through hole of through hole array.
2. microneedle injection bullet according to claim 1, it is characterized in that: also comprise cover plate, cover plate is positioned at the back side of microneedle array thin film, cover plate is connected with substrate, form the shell of microneedle array thin film, microneedle array thin film is sandwiched between cover plate and substrate, cover plate has the through hole array alignd with the through hole array on substrate.
3. microneedle injection bullet according to claim 2, is characterized in that: described cover plate has syndeton, microneedle injection bullet is arranged on the injection port place at micropin propulsion plant by the syndeton on cover plate.
4. microneedle injection bullet according to claim 1, is characterized in that: the micropin of described microneedle array thin film is solubilized micropin, in micropin, have active agents, and solubilized micropin comprises at least one soluble polymeric thing, and soluble polymeric thing is hyaluronic acid, fibroin albumen, collagen protein, gelatin, hydrogel, carboxymethyl cellulose, hydroxypropyl emthylcellulose, chondroitin sulfate, glycogen, dextrin, amylose, chondroitin sulfate, polylactic-co-glycolic acid, Poly(D,L-lactide-co-glycolide, PVOH ester, polyvinyl alcohol, polyacrylic acid, polypropylene, Merlon, polystyrene, polyethylene, polrvinyl chloride, ABS plastic, polydimethylsiloxane, Kynoar, acetate fiber, polyester, polyurethane, poly-dioxy ring ethyl ketone, Polyethylene Glycol, polylactic acid, polyacrylamide polymer, cyclic olefin copolymer, carboxymethyl chitosan, Poly-L-lactic acid, alginic acid, glucosan, dextran sulfate, hydroxypropyl emthylcellulose, chitin, polyvinylpyrrolidone, lactose, galactose, trehalose, sucrose, maltose, glucosan, glucosides, fructose, chitosan, agarose, Sorbitol, mannitol or xylitol, Dan Baiduotang proteoglycan PG, phosphatidylcholine, polylactide, PGA, hydroxypropyl cellulose, wax, polyester, polyanhydride, polyamide, phosphorus based polymer, polybutylcyanoacrylate, polyurethane, poe, poly-dihydropyran, polyacetals, Biodegradable polymeric, polypeptide or carbohydrate, in micropin, have at least one active agents, active agents is citric acid, protein, peptide, polysaccharide, antigen, immunogen, vaccine, antibody, enzyme, nucleic acid, aptamer, virus, antibacterial, cell, hormone, antibiotic, cancer therapy drug, genetically engineered drug, natural product medicine, Chinese medicine ingredients, nutritional labeling, therapeutic agent or diagnostic agent.
5. a microneedle injection equipment, is characterized in that: comprise claim 1 or 2 or the microneedle injection bullet described in 3 or 4 and micropin propulsion plant, and micropin propulsion plant is by each micropin of microneedle array and microneedle array thin film separation and be pressed into skin.
6. microneedle injection equipment according to claim 5, it is characterized in that: described microneedle injection bullet is arranged on the injection port of micropin propulsion plant, micropin propulsion plant is the micropin propulsion plant based on gases at high pressure, based on gases at high pressure the back side from micropin propulsion plant to microneedle injection bullet apply gases at high pressure, promote micropin by gases at high pressure and depart from microneedle array thin film, press-in skin
Or micropin propulsion plant is the micropin propulsion plant based on micro-lance, the micropin propulsion plant based on micro-lance inserts micro-lance array to the back side of microneedle injection bullet, promotes micropin depart from microneedle array thin film by micro-lance of micro-lance array, press-in skin.
7. microneedle injection equipment according to claim 6, it is characterized in that: the described micropin propulsion plant based on gases at high pressure has injecting cavity, high pressure chest, high-pressure air source, valve train, air valve knocking gear and cocking mechanism, high-pressure air source passes into gases at high pressure to high pressure chest, high pressure chest is communicated by valve train with injecting cavity, cocking mechanism controls the needle that air valve knocking gear hits valve train, valve train is opened fast, the front opening of injecting cavity, this opening is as injection port, microneedle injection bullet is arranged on this opening part, the gases at high pressure entering injecting cavity promote micropin and depart from microneedle array thin film, press-in skin.
8. microneedle injection equipment according to claim 7, it is characterized in that: described micropin propulsion plant is pistol shape, the gentle valve jacket mechanism of injecting cavity, high pressure chest, valve train is positioned at the body of a gun part of micropin propulsion plant, the gentle valve jacket mechanism of injecting cavity, high pressure chest, valve train is arranged in order along the length direction of body of a gun part, injecting cavity is positioned at body of a gun part foremost
Valve train comprises valve opening and air valve needle, valve opening communicates with high pressure chest, in valve opening, there is air vent, air vent is communicated with injecting cavity by aerofluxus gas circuit, air valve needle is arranged in valve opening movably linearly, have between air valve needle and valve opening and be sealed and matched, valve opening is exposed in the rear end of air valve needle, air valve needle is opened between air valve needle and valve opening by the mode moved forward and is sealed and matched, the high pressure gas in high pressure chest is made to enter injecting cavity by air vent and aerofluxus gas circuit, air valve needle moves forward into horizontal reset backward by spring, keep the state that is sealed and matched between air valve needle and valve opening,
Air valve knocking gear comprises impact block and propelling spring, and cocking mechanism release impact block, makes impact block under the promotion of propelling spring, hit the rear end of the needle of valve train.
9. microneedle injection equipment according to claim 6, it is characterized in that: the described micropin propulsion plant based on micro-lance comprises the micro-lance array on elastic outer cover, micro-lance substrate and micro-lance substrate one side end face, micro-lance array aligns with the microneedle array of microneedle injection bullet, the opposite side end face of micro-lance substrate is connected with elastic outer cover, the opening of elastic outer cover is as injection port, microneedle injection bullet is arranged on the opening part of elastic outer cover, micro-lance array press-in microneedle injection bullet, and promote micropin disengaging microneedle array thin film, press-in skin.
10. microneedle injection equipment according to claim 9, it is characterized in that: described microneedle injection bullet also comprises cover plate, cover plate is positioned at the back side of microneedle array thin film, cover plate is connected with substrate, form the shell of microneedle array thin film, microneedle array thin film is sandwiched between cover plate and substrate, cover plate has the through hole array alignd with the through hole array on substrate, and described cover plate or substrate have the guide frame led to the lifting moving of micro-lance substrate.
The preparation method of 11. 1 kinds of microneedle injection bullets according to claim 1, is characterized in that: step specific as follows:
A, in micropin female mold, fill up micropin body pre-polymer solution and solidify, obtained microneedle array thin film;
The back side of the film substrate of microneedle array thin film is after hardening pasted in B, transfer base substrate pressing surface with pressure sensitive adhesive, for being glued by microneedle array thin film, departs from former;
C, utilize transfer base substrate by microneedle array film transfer to substrate, and alignd with through hole array by microneedle array, make micropin be embedded in the through hole of substrate, the end face of substrate scribbles viscose glue, and microneedle array thin film is fixed by viscose glue and substrate bonding;
D, pressure sensitive adhesive and microneedle array thin film to be departed from, obtain microneedle injection bullet according to claim 1.
The preparation method of 12. microneedle injection bullets according to claim 2, is characterized in that: step specific as follows:
A, in micropin female mold, fill up micropin body pre-polymer solution and solidify, obtained microneedle array thin film;
The back side of the film substrate of microneedle array thin film is after hardening pasted in B, transfer base substrate pressing surface with pressure sensitive adhesive, for being glued by microneedle array thin film, departs from former;
C, utilize transfer base substrate by microneedle array film transfer to substrate, and alignd with through hole array by microneedle array, make micropin be embedded in the through hole of substrate, the end face of substrate scribbles viscose glue, and microneedle array thin film is fixed by viscose glue and substrate bonding;
D, pressure sensitive adhesive and microneedle array thin film to be departed from, obtain microneedle injection bullet according to claim 1;
E, cover at the back side of microneedle array thin film by cover plate, the through hole array of cover plate and the through hole array of substrate are alignd by position mark simultaneously.
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