CN105126155A - Medical antibacterial swelling relieving material and preparation method of medical antibacterial swelling relieving material - Google Patents
Medical antibacterial swelling relieving material and preparation method of medical antibacterial swelling relieving material Download PDFInfo
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- CN105126155A CN105126155A CN201510613696.XA CN201510613696A CN105126155A CN 105126155 A CN105126155 A CN 105126155A CN 201510613696 A CN201510613696 A CN 201510613696A CN 105126155 A CN105126155 A CN 105126155A
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- medical antibacterial
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- detumescence
- crosslinking agent
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Abstract
The invention discloses a medical antibacterial swelling relieving material and a preparation method of the medical antibacterial swelling relieving material. The material comprises the following ingredients including a bacterial cellulose membrane, nano-silver, angelica root extracts, hypromellose, radix zanthoxyli extracts, polyvinylpyrrolidone and composite cross linking agents, wherein the composite cross linking agents are formed by compounding lauroyl peroxide, methacrylic acid-2-hydroxyethyl acrylate and 2-ethyl-4-methylimidazole. According to the preparation method of the material, the hypromellose, the angelica root extracts and the radix zanthoxyli extracts are added into deionized water and are uniformly mixed to obtain a first mixed solution; the polyvinylpyrrolidone is dissolved into ethylene glycol, nanometer silver is added, the temperature is raised and is maintained for a certain period of time, then, filtering is carried out, and solid materials are cleaned by the deionized water and are then dried and crushed to obtain a first material; the bacterial cellulose membrane is added into the first mixed solution, after the soaking, the temperature is raised to the maintaining temperature, then, the composite cross linking agents are added, the temperature is raised for cross linking, and the medical antibacterial swelling relieving material is obtained. The material provided by the invention has an obvious effect, and is suitable for being popularized and used.
Description
Technical field
The invention belongs to medical material field, be specifically related to a kind of medical antibacterial detumescence material and preparation method thereof.
Background technology
Bacterial cellulose (BC), also known as micro organism cellulose, is a kind ofly have unique nanostructured and the macromolecular material of excellent comprehensive performance.Due to the structure of its uniqueness and than better mechanical performances such as plant celluloses, BC is expected to be used in a lot of field, as organizational project and bio-medical material, and photoelectric material, fuel cell, sewage disposal, food industry, paper industry and army's industry etc.BC fibre diameter is 20-100nm, and single fiber length is very long.Therefore, BC unit mass has very high surface area.This characteristic adds the hydrophilic of its height, is the major reason that BC has high water-holding capacity.In addition, good biocompatibility makes it all become in the extensive use of different field the candidate materials had a great attraction, particularly the application of those relevant biomedicines and biotechnology aspect.In recent years, large quantifier elimination is had to be devoted to BC to be designed to the desirable biology doctor of a large class. treat apparatus and material, as artificial skin, artificial blood vessel, artificial cornea, cardiac valve, artificial urethra, artificial bone, artificial cartilage, artificial knee joint meniscus and pharmaceutical carrier, hormone carrier and protein carrier etc.Existing experimentation and clinical therapeutic efficacy have proved have good behaviour and application prospect based on heal dielectric material, wound dressing and skin tissue engineering scaffold of the wound of BC.In the medical antibacterial detumescence material of current routine, dressing based on Bacterial cellulose is also few, this dressing simultaneously needs long crosslinking curing in preparation process, production cycle is long, and product stability after common conventional cross-linking agents is unsatisfactory, this have impact on the large-scale production of this product to a great extent.
Summary of the invention
The object of the invention is to overcome the deficiencies in the prior art and provide a kind of medical antibacterial to subside a swelling material and preparation method thereof, improving preparation efficiency, the medical antibacterial simultaneously prepared detumescence material has the effects such as good antibacterial, hemostasis.
Technical scheme of the present invention is as follows:
A kind of medical antibacterial detumescence material, comprise in components by weight percent: bacteria cellulose film 50-70 part, nanometer silver 0.5-2 part, Radix Angelicae Dahuricae extract 3-7 part, hypromellose 2-4 part, Radix Zanthoxyli extract 2-5 part, polyvinylpyrrolidone 1-3 part and multiple crosslinking agent 1-3 part, wherein multiple crosslinking agent is by lauroyl peroxide, and 2-hydroxyethyl methacry-late and 2-ethyl-4-methylimidazole are composited.
Described medical antibacterial detumescence material; multiple crosslinking agent recombination process is that 2-hydroxyethyl methacry-late and 2-ethyl-4-methylimidazole are heated to 50-60 DEG C under the condition of protection of ammonia; reaction 40-60 minute; be down to room temperature; add lauroyl peroxide; and then 60-70 DEG C is heated under condition of negative pressure, stirring reaction 20-30 minute, obtains multiple crosslinking agent.
3. medical antibacterial detumescence material according to claim 2, it is characterized in that, described lauroyl peroxide, the mass ratio of 2-hydroxyethyl methacry-late and 2-ethyl-4-methylimidazole is 1:3:2.
Described medical antibacterial detumescence material, the pressure of described condition of negative pressure is 0.01-0.05MPa.
The preparation method of described medical antibacterial detumescence material, comprises the following steps:
Step one, hypromellose, Radix Angelicae Dahuricae extract and Radix Zanthoxyli extract being joined weight portion is in 50-100 part deionized water, is heated to 50-60 DEG C, is uniformly mixed, obtain mixed liquor one;
Step 2, polyvinylpyrrolidone being dissolved in weight portion is in the ethylene glycol of 20-30 part, add nanometer silver, be warming up to 80-100 DEG C, keeps 5-10 minute, is down to room temperature, filters, and solids washed with de-ionized water post-drying is pulverized, obtains material one;
Step 3, adds bacteria cellulose film in mixed liquor one, soaks 100-150 minute, is then warming up to 40-45 DEG C, keeps 20-30 minute, then adds multiple crosslinking agent, be warming up to 50-60 DEG C, reaction 2-4 hour, obtains medical antibacterial detumescence material.
The preparation method of described medical antibacterial detumescence material, a kind of mixing speed be uniformly mixed of step is 120-150 rev/min, is uniformly mixed time 20-30 minute.
The preparation method of described medical antibacterial detumescence material, drying in step 2 and being crushed to particle diameter is less than 300 μm.
Medical antibacterial detumescence material provided by the invention has excellent antibacterial detumescence function, has huge application advantage compared with existing traditional material.
Detailed description of the invention
Below by embodiment, technical scheme of the present invention is further described.Multiple crosslinking agent wherein described in embodiment is by lauroyl peroxide; 2-hydroxyethyl methacry-late and 2-ethyl-4-methylimidazole are composited; be specially: 2-hydroxyethyl methacry-late and 2-ethyl-4-methylimidazole are heated to 50-60 DEG C under the condition of protection of ammonia; reaction 40-60 minute; be down to room temperature, add lauroyl peroxide, and then at pressure be 0.01-0.05MPa condition of negative pressure under be heated to 60-70 DEG C; stirring reaction 20-30 minute, obtains multiple crosslinking agent.Wherein lauroyl peroxide, the mass ratio of 2-hydroxyethyl methacry-late and 2-ethyl-4-methylimidazole is 1:3:2.
Embodiment 1
A kind of medical antibacterial detumescence material, comprises in components by weight percent: bacteria cellulose film 50 parts, nanometer silver 0.5 part, Radix Angelicae Dahuricae extract 3 parts, hypromellose 2 parts, Radix Zanthoxyli extract 2 parts, polyvinylpyrrolidone 1 part and multiple crosslinking agent 1 part.
The preparation method of described medical antibacterial detumescence material, comprises the following steps:
Step one, hypromellose, Radix Angelicae Dahuricae extract and Radix Zanthoxyli extract being joined weight portion is in 50 parts of deionized waters, and be heated to 50 DEG C, be uniformly mixed, mixing speed is 120 revs/min, is uniformly mixed 20 minutes time, obtains mixed liquor one;
Step 2, polyvinylpyrrolidone being dissolved in weight portion is in the ethylene glycol of 20 parts, adds nanometer silver, is warming up to 80 DEG C, keeps 5 minutes, is down to room temperature, filters, and by solids washed with de-ionized water post-drying and to be crushed to particle diameter be less than 300 μm, obtains material one;
Step 3, adds bacteria cellulose film in mixed liquor one, soaks 100 minutes, is then warming up to 40 DEG C, keeps 20 minutes, then adds multiple crosslinking agent, be warming up to 50 DEG C, reacts 2 hours, obtains medical antibacterial detumescence material.
Embodiment 2
A kind of medical antibacterial detumescence material, comprises in components by weight percent: bacteria cellulose film 53 parts, nanometer silver 0.6 part, Radix Angelicae Dahuricae extract 4 parts, hypromellose 3 parts, Radix Zanthoxyli extract 3 parts, polyvinylpyrrolidone 2 parts and multiple crosslinking agent 2 parts.
The preparation method of described medical antibacterial detumescence material, comprises the following steps:
Step one, hypromellose, Radix Angelicae Dahuricae extract and Radix Zanthoxyli extract being joined weight portion is in 60 parts of deionized waters, and be heated to 52 DEG C, be uniformly mixed, mixing speed is 130 revs/min, is uniformly mixed 24 minutes time, obtains mixed liquor one;
Step 2, polyvinylpyrrolidone being dissolved in weight portion is in the ethylene glycol of 25 parts, adds nanometer silver, is warming up to 87 DEG C, keeps 7 minutes, is down to room temperature, filters, and by solids washed with de-ionized water post-drying and to be crushed to particle diameter be less than 300 μm, obtains material one;
Step 3, adds bacteria cellulose film in mixed liquor one, soaks 120 minutes, is then warming up to 43 DEG C, keeps 22 minutes, then adds multiple crosslinking agent, be warming up to 54 DEG C, reacts 3 hours, obtains medical antibacterial detumescence material.
Embodiment 3
A kind of medical antibacterial detumescence material, comprises in components by weight percent: bacteria cellulose film 63 parts, nanometer silver 1.5 parts, Radix Angelicae Dahuricae extract 6 parts, hypromellose 3 parts, Radix Zanthoxyli extract 4 parts, polyvinylpyrrolidone 2 parts and multiple crosslinking agent 2 parts.
The preparation method of described medical antibacterial detumescence material, comprises the following steps:
Step one, hypromellose, Radix Angelicae Dahuricae extract and Radix Zanthoxyli extract being joined weight portion is in 80 parts of deionized waters, and be heated to 55 DEG C, be uniformly mixed, mixing speed is 140 revs/min, is uniformly mixed 27 minutes time, obtains mixed liquor one;
Step 2, polyvinylpyrrolidone being dissolved in weight portion is in the ethylene glycol of 28 parts, adds nanometer silver, is warming up to 90 DEG C, keeps 8 minutes, is down to room temperature, filters, and by solids washed with de-ionized water post-drying and to be crushed to particle diameter be less than 300 μm, obtains material one;
Step 3, adds bacteria cellulose film in mixed liquor one, soaks 140 minutes, is then warming up to 43 DEG C, keeps 25 minutes, then adds multiple crosslinking agent, be warming up to 55 DEG C, reacts 3 hours, obtains medical antibacterial detumescence material.
Embodiment 4
A kind of medical antibacterial detumescence material, comprises in components by weight percent: bacteria cellulose film 70 parts, nanometer silver 2 parts, Radix Angelicae Dahuricae extract 7 parts, hypromellose 4 parts, Radix Zanthoxyli extract 5 parts, polyvinylpyrrolidone 3 parts and multiple crosslinking agent 3 parts.
The preparation method of described medical antibacterial detumescence material, comprises the following steps:
Step one, hypromellose, Radix Angelicae Dahuricae extract and Radix Zanthoxyli extract being joined weight portion is in 100 parts of deionized waters, and be heated to 60 DEG C, be uniformly mixed, mixing speed is 150 revs/min, is uniformly mixed 30 minutes time, obtains mixed liquor one;
Step 2, polyvinylpyrrolidone being dissolved in weight portion is in the ethylene glycol of 30 parts, adds nanometer silver, be warming up to 100 DEG C, keep 10 minutes, be down to room temperature, filter, by solids washed with de-ionized water post-drying and to be crushed to particle diameter be less than 300 μm, obtain material one;
Step 3, adds bacteria cellulose film in mixed liquor one, soaks 150 minutes, is then warming up to 45 DEG C, keeps 30 minutes, then adds multiple crosslinking agent, be warming up to 60 DEG C, reacts 4 hours, obtains medical antibacterial detumescence material.
The medical antibacterial detumescence material above embodiment prepared carries out antibacterial detumescence test: in April, 2015-July is in shallow table abscess patient 80 example of certain hospital admission, age 18-60 year, stochastic averagina is distributed into 4 groups, wherein two groups use traditional wound repair antiseptic dressing, another two groups of antibacterial detumescence materials using the present invention to prepare, observe swelling time, do not infect for recovery from illness to subside a swelling completely simultaneously, observe the recovery from illness quantity of different time, two groups of recovery from illness quantity summations contrasted, result is as following table:
Can be drawn by above result of the test, the medical antibacterial detumescence material that above embodiment prepares can be subsided a swelling to affected part rapidly, and in detumescence process, serve anti-infective effect simultaneously, compared with repairing antiseptic dressing with tradition conventional at present, there is obvious advantage.
Claims (7)
1. a medical antibacterial detumescence material, it is characterized in that, comprise in components by weight percent: bacteria cellulose film 50-70 part, nanometer silver 0.5-2 part, Radix Angelicae Dahuricae extract 3-7 part, hypromellose 2-4 part, Radix Zanthoxyli extract 2-5 part, polyvinylpyrrolidone 1-3 part and multiple crosslinking agent 1-3 part, wherein multiple crosslinking agent is by lauroyl peroxide, and 2-hydroxyethyl methacry-late and 2-ethyl-4-methylimidazole are composited.
2. medical antibacterial detumescence material according to claim 1; it is characterized in that; multiple crosslinking agent recombination process is that 2-hydroxyethyl methacry-late and 2-ethyl-4-methylimidazole are heated to 50-60 DEG C under the condition of protection of ammonia; reaction 40-60 minute; be down to room temperature, add lauroyl peroxide, and then be heated to 60-70 DEG C under condition of negative pressure; stirring reaction 20-30 minute, obtains multiple crosslinking agent.
3. medical antibacterial detumescence material according to claim 2, it is characterized in that, described lauroyl peroxide, the mass ratio of 2-hydroxyethyl methacry-late and 2-ethyl-4-methylimidazole is 1:3:2.
4. medical antibacterial detumescence material according to claim 2, it is characterized in that, the pressure of described condition of negative pressure is 0.01-0.05MPa.
5. a preparation method for medical antibacterial detumescence material according to claim 1, is characterized in that, comprise the following steps:
Step one, hypromellose, Radix Angelicae Dahuricae extract and Radix Zanthoxyli extract being joined weight portion is in 50-100 part deionized water, is heated to 50-60 DEG C, is uniformly mixed, obtain mixed liquor one;
Step 2, polyvinylpyrrolidone being dissolved in weight portion is in the ethylene glycol of 20-30 part, add nanometer silver, be warming up to 80-100 DEG C, keeps 5-10 minute, is down to room temperature, filters, and solids washed with de-ionized water post-drying is pulverized, obtains material one;
Step 3, adds bacteria cellulose film in mixed liquor one, soaks 100-150 minute, is then warming up to 40-45 DEG C, keeps 20-30 minute, then adds multiple crosslinking agent, be warming up to 50-60 DEG C, reaction 2-4 hour, obtains medical antibacterial detumescence material.
6. the preparation method of medical antibacterial detumescence material according to claim 5, it is characterized in that, a kind of mixing speed be uniformly mixed of step is 120-150 rev/min, is uniformly mixed time 20-30 minute.
7. the preparation method of medical antibacterial detumescence material according to claim 5, it is characterized in that, drying in step 2 and being crushed to particle diameter is less than 300 μm.
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| CN201510613696.XA CN105126155A (en) | 2015-09-23 | 2015-09-23 | Medical antibacterial swelling relieving material and preparation method of medical antibacterial swelling relieving material |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106473837A (en) * | 2016-03-17 | 2017-03-08 | 黄飞 | Artificial cornea |
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| CN1557150A (en) * | 2004-02-13 | 2004-12-29 | 黄德欢 | Nanometer silver antiseptic powder preparation method |
| CN1944495A (en) * | 2006-09-29 | 2007-04-11 | 北京大学 | Water gel containing natural high molecule and its radiation preparing method |
| CN101215388A (en) * | 2008-01-15 | 2008-07-09 | 东华大学 | Method for preparing bacteria cellulose composite membrane |
| CN101311215A (en) * | 2007-05-22 | 2008-11-26 | 东进世美肯株式会社 | Organic protective film composition |
| CN100557163C (en) * | 2007-11-30 | 2009-11-04 | 康玉范 | Anchor, sticking complex heat-preservation board exterior wall outer thermal insulation construction method |
| CN103422255A (en) * | 2012-05-17 | 2013-12-04 | 五邑大学 | Method for preparing nano-silver-containing composite fibrous membrane capable of being used for medical dressings |
-
2015
- 2015-09-23 CN CN201510613696.XA patent/CN105126155A/en not_active Withdrawn
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1557150A (en) * | 2004-02-13 | 2004-12-29 | 黄德欢 | Nanometer silver antiseptic powder preparation method |
| CN1944495A (en) * | 2006-09-29 | 2007-04-11 | 北京大学 | Water gel containing natural high molecule and its radiation preparing method |
| CN101311215A (en) * | 2007-05-22 | 2008-11-26 | 东进世美肯株式会社 | Organic protective film composition |
| CN100557163C (en) * | 2007-11-30 | 2009-11-04 | 康玉范 | Anchor, sticking complex heat-preservation board exterior wall outer thermal insulation construction method |
| CN101215388A (en) * | 2008-01-15 | 2008-07-09 | 东华大学 | Method for preparing bacteria cellulose composite membrane |
| CN103422255A (en) * | 2012-05-17 | 2013-12-04 | 五邑大学 | Method for preparing nano-silver-containing composite fibrous membrane capable of being used for medical dressings |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106473837A (en) * | 2016-03-17 | 2017-03-08 | 黄飞 | Artificial cornea |
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