CN105110260A - Tamponade method of card bottle and device of tamponade method - Google Patents
Tamponade method of card bottle and device of tamponade method Download PDFInfo
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- CN105110260A CN105110260A CN201510507492.8A CN201510507492A CN105110260A CN 105110260 A CN105110260 A CN 105110260A CN 201510507492 A CN201510507492 A CN 201510507492A CN 105110260 A CN105110260 A CN 105110260A
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- tamponade
- clamped bottle
- sleeve
- bottle
- clamped
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Abstract
The invention discloses a tamponade method of a card bottle and a device of the tamponade method, and belongs to the technical field of card bottle freeze-drying and card bottle subpackaging/filling. According to the tamponade method of the card bottle disclosed by the invention, an interspace is produced between a rubber plug and inner walls of a card bottle as a gas passage in the process of tamponade. The tamponade device of the card bottle disclosed by the invention comprises a piston rod used for tamponade, and a separation device, wherein the separation device enables that the rubber plug and the inner walls of the card bottle are partly or wholly separated in the process of tamponade so that the gas passage is produced. According to the tamponade method disclosed by the invention, a plug stuffing movement of a reagent in the card bottle can be completed in the process of freeze-drying, and the preparation of needle preparations of freeze-dried powder of the card bottle can be realized; the traditional filling technology of the squirt cut preparations and the subpackaging technology of needle preparations of sterile powder of the card bottle are changed; the problems that the conventional technology process is miscellaneous and the consistency is difficult to guarantee are solved; the tamponade device of the card bottle is convenient to operate and simple in structure; the conventional equipment is easy to reform, so that the automatic production of the tamponade device of the card bottle is convenient to popularize.
Description
Technical field
The present invention relates to clamped bottle freeze-drying and clamped bottle packing/Canning Technique field, be specifically related to a kind of clamped bottle tamponade method and device.
Background technology
Clamped bottle has another name called borosilicate glass sleeve for pen type syringe, is the inner container for splendid attire liquid drugs injection or powder injection formulation of pen-type injector.The similar syringe not having push rod of clamped bottle, is equivalent to " not having bottle with the end ".This bottle of head is equipped with the injection needle of rubber seal protection, and bottleneck plug aluminium lid sealing, afterbody rubber piston seals.Clamped bottle is inserted in reusable cassette injection holder or injection pen and is used, and use procedure liquid is any component contact with syringe not.
At present, the filling and packing flow process of clamped bottle preparation (comprising clamped bottle liquid drugs injection and clamped bottle aseptic powder injection) is: clamped bottle adds piston → filling/packing medicine → roll lid, namely first by tail seal, reinstalls medicine, and then by head seal.Otherwise, roll lid → filling/packing medicine → add piston if flow process changed into, then because process intermediate champing bottle inside and outside pressure of jumping a queue is identical, after jumping a queue, pressure of the inside of a bottle is greater than a bottle external pressure, plug can eject by the effect of bottle inside and outside differential pressure in bottle, causes the process of jumping a queue to realize.
Meanwhile, said method is utilized cannot to jump a queue to the clamped bottle in freeze-drying process equally.On the contrary, if jump a queue to the clamped bottle in freeze-drying under vacuum conditions, although the process of jumping a queue can complete, but when the clamped bottle after jumping a queue carries out multiple pressure, pressure due to clamped bottle outside is greater than clamped bottle internal pressure, now plug can directly be forced into clamped bottle innermost under differential pressure action, and destroys the medicine in clamped bottle.Therefore, just based on adding blocking method at present not for clamped bottle, the freeze-dried powder of clamped bottle cannot realize.In addition, in the filling flow process of traditional clamped bottle, the filling amount of hydro-acupuncture preparation is determined by the stroke of piston in clamped bottle, adds the inconsistency that the inconsistency of piston position in Piston Process and fugitiveness directly cause filling amount.For ensureing the conformability of filling amount further, liquid drug process needs again to be divided into expendable and secondary supplementary irrigation, and the conformability of filling amount is difficult to ensure, and pouring process is loaded down with trivial details.
Summary of the invention
The present invention is directed to the proposition of above problem, and a kind of clamped bottle tamponade method of research and design and device.The technological means that the present invention adopts is as follows:
A kind of clamped bottle tamponade method, makes in tamponade process to produce space as gas passage between plug and clamped bottle inwall.
Further, the piston rod for tamponade and the disengagement gear that plug can be made with all or part of separation of clamped bottle inwall in tamponade process to produce gas passage is comprised.
Further, described disengagement gear comprises sleeve and venting pin, described jacket casing is located at outside piston rod, the inside of described sleeve is shoulder hole structure, the large diameter portion of stepped hole is sheathed on clamped bottle end, the internal diameter of the path part of stepped hole equals the internal diameter of clamped bottle, and described venting is sold one end and is fixed on the inwall of sleeve path part, and the other end stretches in clamped bottle in tamponade process.
Further, described disengagement gear comprises the sleeve be sheathed on outside piston rod, and described sleeve can insert clamped bottle, and the sidewall of described sleeve is provided with strip shape breach as gas passage.
Further, described disengagement gear comprises the sleeve be sheathed on outside piston rod, and described sleeve can insert clamped bottle, and inserts between the outer wall of sleeve after clamped bottle and the inwall of clamped bottle and have space.
Further, described sleeve cross section is oval, that external diameter is less than the internal diameter of clamped bottle circle, part circular and the combined shaped of ellipse or the combined shaped of different-diameter circle.
Further, described disengagement gear comprises the sleeve be sheathed on outside piston rod, and described sleeve can insert clamped bottle, and the inwall of described sleeve is provided with longitudinal strip bulge.
Further, the outer wall of described sleeve is provided with the spacing preiection inserting clamped bottle length for limiting sleeve.
Compared with the prior art, a kind of clamped bottle tamponade method of the present invention and device have the following advantages:
1, make clamped bottle reagent complete action of jumping a queue in freeze-drying process, realize the preparation of clamped bottle freeze-dried powder;
2, the filling process of traditional hydro-acupuncture preparation and the layered water flood well of clamped bottle aseptic powder injection preparation is changed, formed roll lid → this new clamped bottle of filling/separate loading medicine bottle → tamponade filling/layered water flood well, solve the numerous and diverse and conforming problem of very difficult guarantee of existing technological process;
3, clamped bottle tamponade method of the present invention is easy to operate, and clamped bottle tamponade device structure is simple, and existing installation is easy to realize transformation, is convenient to the popularization of automated production.
Accompanying drawing explanation
Fig. 1 is the structural representation before the embodiment of the present invention one tamponade.
Fig. 2 is the structural representation in the embodiment of the present invention one tamponade process.
Fig. 3 is the structural representation of the embodiment of the present invention one tamponade to assigned address.
Fig. 4 is the schematic cross-section at plug place in the embodiment of the present invention one tamponade process.
Fig. 5 is the structural representation before the embodiment of the present invention two tamponade.
Fig. 6 is the structural representation in the embodiment of the present invention two tamponade process.
Fig. 7 is the structural representation of the embodiment of the present invention two tamponade to assigned address.
Fig. 8 is the schematic cross-section at plug place in the embodiment of the present invention two tamponade process.
Fig. 9 is the schematic cross-section at plug place in the embodiment of the present invention three tamponade process.
Figure 10 is the schematic cross-section at plug place in the embodiment of the present invention four tamponade process.
Figure 11 is the schematic cross-section at plug place in the embodiment of the present invention five tamponade process.
Figure 12 is the schematic cross-section at plug place in the embodiment of the present invention six tamponade process.
Figure 13 is the schematic cross-section at plug place in the embodiment of the present invention seven tamponade process.
Detailed description of the invention
A kind of clamped bottle tamponade method, makes in tamponade process to produce space as gas passage between plug and clamped bottle inwall.
As shown in figures 1-13, a kind of clamped bottle tamponade device, comprise for tamponade piston rod 1 with can make plug 3 disengagement gear that be separated and then produce gas passage 6 all or part of with clamped bottle 5 inwall in tamponade process.
Embodiment one
As Figure 1-4, a kind of clamped bottle tamponade device, comprise for tamponade piston rod 1 with can make plug 3 disengagement gear that be separated and then produce gas passage 6 all or part of with clamped bottle 5 inwall in tamponade process.Described disengagement gear comprises sleeve 2 and venting pin 4, described sleeve 2 is sheathed on outside piston rod 1, the inside of described sleeve 2 is shoulder hole structure, the large diameter portion of stepped hole is sheathed on clamped bottle 5 end, the internal diameter of the path part of stepped hole equals the internal diameter of clamped bottle 5, and described venting pin 4 one end is fixed on the inwall of sleeve 2, and the other end stretches out sleeve 2, in tamponade process, one end that venting pin 4 stretches out sleeve 2 is stretched in clamped bottle 5.Conveniently venting pin 4 being inserted clamped bottle, by the direction bending certain angle of the end of venting pin 4 to clamped bottle 5 center shaft, preventing the situation that venting pin 4 not easily inserts when inserting clamped bottle 5.Venting pin 4 can only arrange one, also can arrange more than two as required.
During tamponade, engine installation promotes piston rod 1 and moves down, and sleeve 2 lower end is enclosed within clamped bottle, and venting pin 4 stretches into clamped bottle 5, and piston rod 1 continues to move down, and sleeve 2 invariant position, plug 3 pushes in clamped bottle 5 by piston rod 1.Now, due to the existence of pin 4 of exitting, cannot fully contact between plug 3 with clamped bottle 5, produce gas passage 6, the gas in clamped bottle 5 can discharge clamped bottle 5 by gas passage 6 smoothly.When plug 3 is pulled to specified location, piston rod 1 stops moving down, and extracts out from clamped bottle 5, and now, piston rod 1 together gets back to the position before tamponade together with sleeve 2, venting pin 4, and piston 3 then stays the assigned address in clamped bottle 5.Tamponade process completes.
Embodiment two
As viewed in figures 5-8, a kind of clamped bottle tamponade device, comprise for tamponade piston rod 1 with can make plug 3 disengagement gear that be separated and then produce gas passage all or part of with clamped bottle 5 inwall in tamponade process.Described disengagement gear comprises the sleeve 2 be sheathed on outside piston rod 1, described sleeve 2 can insert clamped bottle 5, the external diameter of sleeve 2 is equal with the internal diameter of clamped bottle 5, and the sidewall of described sleeve 2 is provided with strip shape breach as gas passage 6, makes the c-shaped structure of tubular portion of whole sleeve 2.The strip shape breach of more than two also can be set.In tamponade process, the gas in clamped bottle 5 is discharged from strip shape breach, reaches inside and outside air pressure balance.The outer wall of described sleeve 2 is provided with the spacing preiection 8 inserting clamped bottle 5 length for limiting sleeve 2.Other flow processs of tamponade are with embodiment one.
Embodiment three
As shown in Figure 9, a kind of clamped bottle tamponade device, comprise for tamponade piston rod 1 with can make plug 3 disengagement gear that be separated and then produce gas passage 6 all or part of with clamped bottle 5 inwall in tamponade process.Described disengagement gear comprises the sleeve 2 be sheathed on outside piston rod 1, described sleeve 2 can insert clamped bottle 5, described sleeve 2 cross section is circular, and the external diameter of sleeve 2 is less than the internal diameter of clamped bottle 5, sleeve 2 external diameter is slightly less than the internal diameter of clamped bottle 5, namely gap is defined, as gas passage 6 between sleeve 2 and clamped bottle 5.
Embodiment four
As shown in Figure 10, a kind of clamped bottle tamponade device, comprise for tamponade piston rod 1 with can make plug 3 disengagement gear that be separated and then produce gas passage 6 all or part of with clamped bottle 5 inwall in tamponade process.Described disengagement gear comprises the sleeve 2 be sheathed on outside piston rod 1, described sleeve 2 can insert clamped bottle, and the cross section of described sleeve 2 is oval, and oval major axis equals the internal diameter of clamped bottle 6, gap is formed, as gas passage 6 between then oval minor axis two ends place and clamped bottle 5 inwall.
Embodiment five
As shown in figure 11, a kind of clamped bottle tamponade device, comprise for tamponade piston rod 1 with can make plug 3 disengagement gear that be separated and then produce gas passage 6 all or part of with clamped bottle 5 inwall in tamponade process.Described disengagement gear comprises the sleeve 2 be sheathed on outside piston rod 1, described sleeve 2 can insert clamped bottle 5, the half at the edge in the cross section of described sleeve 2 is circular arc, another half is elliptic arc, the radius of circular arc equals the internal diameter of clamped bottle 5, then produce space between elliptic arc place and clamped bottle 5 inwall, as gas passage 6.
Embodiment six
As shown in figure 12, a kind of clamped bottle tamponade device, comprise for tamponade piston rod 1 with can make plug 3 disengagement gear that be separated and then produce gas passage 6 all or part of with clamped bottle 4 inwall in tamponade process.Described disengagement gear comprises the sleeve 2 be sheathed on outside piston rod 1, described sleeve 2 can insert clamped bottle, the section edges part of described sleeve 2 is that external diameter equals the circular arc of clamped bottle internal diameter, another part is the circular arc that diameter is greater than clamped bottle diameter, space is produced, as gas passage 6 between the circular arc place that then diameter is larger and clamped bottle 5.
Embodiment seven
As shown in figure 13, a kind of clamped bottle tamponade device, comprise for tamponade piston rod 1 with can make plug 3 disengagement gear that be separated and then produce gas passage 6 all or part of with clamped bottle 5 inwall in tamponade process.Described disengagement gear comprises the sleeve 2 be sheathed on outside piston rod 1, described sleeve 2 can insert clamped bottle 5, the inwall of described sleeve 2 is provided with longitudinal strip bulge 7, and longitudinal strip bulge 7 extrudes plug, makes to produce space between plug 3 and sleeve 2 as gas passage 6.
The above; be only the present invention's preferably detailed description of the invention; but protection scope of the present invention is not limited thereto; anyly be familiar with those skilled in the art in the technical scope that the present invention discloses; be equal to according to technical scheme of the present invention and inventive concept thereof and replace or change, all should be encompassed within protection scope of the present invention.
Claims (8)
1. a clamped bottle tamponade method, is characterized in that: make in tamponade process to produce space as gas passage between plug and clamped bottle inwall.
2. for a clamped bottle tamponade device for clamped bottle tamponade method described in claim 1, it is characterized in that: comprise the piston rod for tamponade and the disengagement gear that plug can be made with all or part of separation of clamped bottle inwall in tamponade process to produce gas passage.
3. clamped bottle tamponade device according to claim 2, it is characterized in that: described disengagement gear comprises sleeve and venting pin, described jacket casing is located at outside piston rod, the inside of described sleeve is shoulder hole structure, the large diameter portion of stepped hole is sheathed on clamped bottle end, the internal diameter of the path part of stepped hole equals the internal diameter of clamped bottle, and described venting is sold one end and is fixed on the inwall of sleeve path part, and the other end stretches in clamped bottle in tamponade process.
4. clamped bottle tamponade device according to claim 2, it is characterized in that: described disengagement gear comprises the sleeve be sheathed on outside piston rod, described sleeve can insert clamped bottle, and the sidewall of described sleeve is provided with strip shape breach as gas passage.
5. clamped bottle tamponade device according to claim 2, it is characterized in that: described disengagement gear comprises the sleeve be sheathed on outside piston rod, described sleeve can insert clamped bottle, and inserts between the outer wall of sleeve after clamped bottle and the inwall of clamped bottle and have space.
6. clamped bottle tamponade device according to claim 5, is characterized in that: described sleeve cross section is oval, that external diameter is less than the internal diameter of clamped bottle circle, part circular and the combined shaped of ellipse or the combined shaped of different-diameter circle.
7. clamped bottle tamponade device according to claim 2, it is characterized in that: described disengagement gear comprises the sleeve be sheathed on outside piston rod, described sleeve can insert clamped bottle, and the inwall of described sleeve is provided with longitudinal strip bulge.
8. according to the clamped bottle tamponade device in claim 4-7 described in any one, it is characterized in that: the outer wall of described sleeve is provided with the spacing preiection inserting clamped bottle length for limiting sleeve.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510507492.8A CN105110260A (en) | 2015-08-18 | 2015-08-18 | Tamponade method of card bottle and device of tamponade method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510507492.8A CN105110260A (en) | 2015-08-18 | 2015-08-18 | Tamponade method of card bottle and device of tamponade method |
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| CN105110260A true CN105110260A (en) | 2015-12-02 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510507492.8A Pending CN105110260A (en) | 2015-08-18 | 2015-08-18 | Tamponade method of card bottle and device of tamponade method |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106241685A (en) * | 2016-09-08 | 2016-12-21 | 上海东富龙科技股份有限公司 | A kind of clamped bottle plugging organization |
| CN106864791A (en) * | 2017-04-21 | 2017-06-20 | 山东新华医疗器械股份有限公司 | A kind of precharging type syringe train line bulking system |
| CN107399700A (en) * | 2017-08-21 | 2017-11-28 | 四川成派生物科技有限公司 | A kind of efficiently Packaging Bottle seal assembly |
| CN114132879A (en) * | 2020-09-04 | 2022-03-04 | 湖北福人金身药业有限公司 | Oral liquid bottle pneumatic plugging method |
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| JPH07124228A (en) * | 1993-11-05 | 1995-05-16 | Shibuya Kogyo Co Ltd | Stopper driver |
| US5519984A (en) * | 1995-03-16 | 1996-05-28 | Mallinckrodt Medical, Inc. | Methods for packaging a pressure or vacuum sensitive product |
| CN201010498Y (en) * | 2007-02-11 | 2008-01-23 | 瑞安市华达机械有限公司 | Rubber plug vacuum leading device of prefilled syringe soup filling and enveloping machine |
| CN201040707Y (en) * | 2007-02-11 | 2008-03-26 | 瑞安市华达机械有限公司 | Rubber piston guiding-sheathing leading-in device for pre-filling type injector medical liquid filling sealing machine |
| CN203529888U (en) * | 2013-09-13 | 2014-04-09 | 上海都能制药机械设备有限公司 | Injector vacuumizing and plugging device |
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2015
- 2015-08-18 CN CN201510507492.8A patent/CN105110260A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07124228A (en) * | 1993-11-05 | 1995-05-16 | Shibuya Kogyo Co Ltd | Stopper driver |
| US5519984A (en) * | 1995-03-16 | 1996-05-28 | Mallinckrodt Medical, Inc. | Methods for packaging a pressure or vacuum sensitive product |
| CN201010498Y (en) * | 2007-02-11 | 2008-01-23 | 瑞安市华达机械有限公司 | Rubber plug vacuum leading device of prefilled syringe soup filling and enveloping machine |
| CN201040707Y (en) * | 2007-02-11 | 2008-03-26 | 瑞安市华达机械有限公司 | Rubber piston guiding-sheathing leading-in device for pre-filling type injector medical liquid filling sealing machine |
| CN203529888U (en) * | 2013-09-13 | 2014-04-09 | 上海都能制药机械设备有限公司 | Injector vacuumizing and plugging device |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106241685A (en) * | 2016-09-08 | 2016-12-21 | 上海东富龙科技股份有限公司 | A kind of clamped bottle plugging organization |
| CN106864791A (en) * | 2017-04-21 | 2017-06-20 | 山东新华医疗器械股份有限公司 | A kind of precharging type syringe train line bulking system |
| CN107399700A (en) * | 2017-08-21 | 2017-11-28 | 四川成派生物科技有限公司 | A kind of efficiently Packaging Bottle seal assembly |
| CN114132879A (en) * | 2020-09-04 | 2022-03-04 | 湖北福人金身药业有限公司 | Oral liquid bottle pneumatic plugging method |
| CN114132879B (en) * | 2020-09-04 | 2022-11-29 | 湖北福人金身药业有限公司 | Oral liquid bottle pneumatic plug adding method |
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Effective date of registration: 20160205 Address after: 116000 Liaoning, Dalian, Jinzhou New District, northeast street, No. seven, -5-10, 10 Applicant after: Song Zhantao Address before: 116000 Liaoning, Dalian, Jinzhou New District, northeast street, No. seven, -5-10, 10 Applicant before: DALIAN TIANREY SCIENCE AND TECHNOLOGY CO., LTD. |
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Application publication date: 20151202 |