CN105106232B - A kind of mixture for preventing beaver rabbit fluorine disease - Google Patents
A kind of mixture for preventing beaver rabbit fluorine disease Download PDFInfo
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- CN105106232B CN105106232B CN201510604436.6A CN201510604436A CN105106232B CN 105106232 B CN105106232 B CN 105106232B CN 201510604436 A CN201510604436 A CN 201510604436A CN 105106232 B CN105106232 B CN 105106232B
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- 241000283973 Oryctolagus cuniculus Species 0.000 title claims abstract description 56
- 241000499489 Castor canadensis Species 0.000 title claims abstract description 50
- 235000011779 Menyanthes trifoliata Nutrition 0.000 title claims abstract description 50
- 229910052731 fluorine Inorganic materials 0.000 title claims abstract description 49
- 239000011737 fluorine Substances 0.000 title claims abstract description 49
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 title claims abstract description 48
- 239000000203 mixture Substances 0.000 title claims abstract description 46
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims abstract description 25
- 201000010099 disease Diseases 0.000 title claims abstract description 18
- CADZRPOVAQTAME-UHFFFAOYSA-L calcium;hydroxy phosphate Chemical compound [Ca+2].OOP([O-])([O-])=O CADZRPOVAQTAME-UHFFFAOYSA-L 0.000 claims abstract description 14
- 239000002994 raw material Substances 0.000 claims abstract description 14
- 239000004227 calcium gluconate Substances 0.000 claims abstract description 12
- 229960004494 calcium gluconate Drugs 0.000 claims abstract description 12
- 235000013927 calcium gluconate Nutrition 0.000 claims abstract description 12
- NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 claims abstract description 12
- UWZXJRBXKTZILP-UHFFFAOYSA-L calcium;selenite Chemical compound [Ca+2].[O-][Se]([O-])=O UWZXJRBXKTZILP-UHFFFAOYSA-L 0.000 claims abstract description 12
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 claims abstract description 11
- 239000000920 calcium hydroxide Substances 0.000 claims abstract description 11
- 229910001861 calcium hydroxide Inorganic materials 0.000 claims abstract description 11
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 4
- 229960005069 calcium Drugs 0.000 claims description 4
- 239000011575 calcium Substances 0.000 claims description 4
- 229910052791 calcium Inorganic materials 0.000 claims description 4
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 239000003651 drinking water Substances 0.000 abstract description 18
- 235000020188 drinking water Nutrition 0.000 abstract description 18
- 208000005374 Poisoning Diseases 0.000 abstract description 15
- 231100000572 poisoning Toxicity 0.000 abstract description 15
- 230000000607 poisoning effect Effects 0.000 abstract description 15
- 238000000034 method Methods 0.000 abstract description 14
- 230000002265 prevention Effects 0.000 abstract description 6
- 208000031295 Animal disease Diseases 0.000 abstract description 2
- 230000001627 detrimental effect Effects 0.000 abstract description 2
- 238000012360 testing method Methods 0.000 description 26
- 230000037396 body weight Effects 0.000 description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 208000004042 dental fluorosis Diseases 0.000 description 8
- 238000002474 experimental method Methods 0.000 description 8
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 7
- 241001465754 Metazoa Species 0.000 description 7
- 230000000694 effects Effects 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 5
- 210000000988 bone and bone Anatomy 0.000 description 4
- 231100000636 lethal dose Toxicity 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 206010016818 Fluorosis Diseases 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 230000002940 repellent Effects 0.000 description 3
- 239000005871 repellent Substances 0.000 description 3
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 3
- 230000001954 sterilising effect Effects 0.000 description 3
- 238000004659 sterilization and disinfection Methods 0.000 description 3
- 210000002700 urine Anatomy 0.000 description 3
- 235000019786 weight gain Nutrition 0.000 description 3
- 244000068988 Glycine max Species 0.000 description 2
- 235000010469 Glycine max Nutrition 0.000 description 2
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 2
- 208000031320 Teratogenesis Diseases 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000004459 forage Substances 0.000 description 2
- 230000003862 health status Effects 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 229910052711 selenium Inorganic materials 0.000 description 2
- 239000011669 selenium Substances 0.000 description 2
- 235000013024 sodium fluoride Nutrition 0.000 description 2
- 235000015099 wheat brans Nutrition 0.000 description 2
- 244000025254 Cannabis sativa Species 0.000 description 1
- 235000019739 Dicalciumphosphate Nutrition 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 235000019733 Fish meal Nutrition 0.000 description 1
- 241001233242 Lontra Species 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 235000010716 Vigna mungo Nutrition 0.000 description 1
- 240000001417 Vigna umbellata Species 0.000 description 1
- 235000011453 Vigna umbellata Nutrition 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 1
- 238000011047 acute toxicity test Methods 0.000 description 1
- 235000019730 animal feed additive Nutrition 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 235000014590 basal diet Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229940036811 bone meal Drugs 0.000 description 1
- 239000002374 bone meal Substances 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- MWKXCSMICWVRGW-UHFFFAOYSA-N calcium;phosphane Chemical compound P.[Ca] MWKXCSMICWVRGW-UHFFFAOYSA-N 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
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- 210000003298 dental enamel Anatomy 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 description 1
- 229940038472 dicalcium phosphate Drugs 0.000 description 1
- 229910000390 dicalcium phosphate Inorganic materials 0.000 description 1
- 239000002384 drinking water standard Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000004467 fishmeal Substances 0.000 description 1
- 150000002222 fluorine compounds Chemical class 0.000 description 1
- 235000021393 food security Nutrition 0.000 description 1
- 238000003304 gavage Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000010977 jade Substances 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000011775 sodium fluoride Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000008471 teeth growth Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 210000002303 tibia Anatomy 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
Landscapes
- Fodder In General (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention belongs to Animal diseases prevention technique field, and in particular to a kind of mixture for preventing beaver rabbit fluorine disease.Using calcium selenite, calcium hydroxy phosphate, calcium hydroxide, calcium gluconate as raw material, by being mixed twice.Inventive mixture is put into feed to be used together with drinking-water.The present invention has the purpose that can be played prevention and alleviate high fluorine beaver rabbit fluorine poisoning disease, and does not interfere with the quality of beaver rabbit weightening and hide, the advantages of not being detrimental to health.
Description
Technical field
The invention belongs to Animal diseases prevention technique field, and in particular to a kind of mixture for preventing beaver rabbit fluorine disease.
Background technology
Micro fluorine element is beneficial to animal, when fluoride Excess free enthalpy can cause animal body fluorine poisoning, main table
Existing form is fluorosis of bone and den tal fluorosis.Fluorine poisoning disease distribution is very extensive, and there is place more than 40 individual countries and regions of five continents
Property fluorine disease distribution, in addition to Shanghai City, other each province have fluorine poisoning sick in China.Fluorosis drinking-water Oil repellent is up to 15mg/L
(national drinking water standard is less than 1mg/L), after plant is enriched with to environment fluorine, makes feed Oil repellent be up to 100mg/kg (state's domestic discipline and family rules
Set stocking grass Oil repellent is less than 40mg/kg), even more high, the raw material fluorinated volume such as Production of Dicalcium Phosphate As Animal Feed Additive, bone meal, fish meal
It is higher.Beaver rabbit is by searching for food and drinking-water makes fluorine accumulate in vivo to cause fluorine poisoning.At present, beaver rabbit fluorine poisoning disease preventing and treating also in
In the elementary step, also prevent beaver rabbit fluorine poisoning disease without a kind of simple and effective way, suffer from the beaver rabbit long bone end length of fluorosis of bone
Go out exophytic spur, femur and shin bone shorten thicker, and severe patient causes rabbit skeleton deformity.Den tal fluorosis beaver rabbit enamel early stage is broken
It is bad, deformity teeth growth.Ill beaver rabbit build is short and small, and hair is disorderly, influences hide quality and beaver rabbit weightening.Secondly, beaver rabbit is suffered from
After being ill, the lesion even bone and tooth of teratogenesis, can not return to health status, and rabbit to fluorine poisoning after treatment
Build teratogenesis, if pet rabbit then loses ornamental value.
The content of the invention
The purpose of the present invention be to solve the disease of beaver rabbit fluorine poisoning present in above-mentioned background technology, and influence beaver rabbit weightening and
The problem of hide quality, and provide a kind of by the mixture with the prevention beaver rabbit fluorine of the addition in feed disease of drinking water.
To achieve the above object, the technical solution used in the present invention is：
A kind of mixture for preventing beaver rabbit fluorine disease, is made up of the raw material of following parts by weight：
0.1~0.2 part of calcium selenite, 0.05~0.1 part of calcium hydroxy phosphate, 5~18 parts of calcium hydroxide, calcium gluconate 82
~95 parts；
By above-mentioned raw materials conventionally, first by 0.1~0.2 part of calcium selenite, 0.05~0.1 part of calcium hydroxy phosphate,
After 5~18 parts of calcium hydroxide is well mixed, then with calcium gluconate 82~95 parts be well mixed again, mixture is made.
In order to preferably play a role, specifically used method is inventive mixture：Pressed respectively in feeding material and drinking-water
According to beaver rabbit feed：Mixture=99：1；Drinking-water：Mixture=99：1 ratio is put into the mixture.
In inventive mixture, the pharmacology analysis of each bulk drug is as follows：
Calcium selenite：Interior free yl can be reduced, prevents Antioxidation, protects the film phase constitution of cell,
Damage of the fluorine poisoning to cell is prevented and treated, selenium can promote fluorine to be discharged with urine, in addition, selenium has the function that to increase the weight of animals.
Calcium gluconate：Generation generation slightly solubility calcirm-fluoride can be combined with fluorine, promotes the outer row of fluorine, in feed
More than 10mg/Kg or drinking-water in more than 10mg/Kg fluoride, there is very strong binding ability, provide calcium source in addition for body,
Suppress fluorine disease.
Calcium hydroxy phosphate：There is extremely strong binding ability for the even lower concentration fluoride of 1mg/Kg fluorides, have solid
Fixed and discharge fluorine effect, improves the discharge rate of excrement fluoride, calcium and phosphorus is provided for animal body, coordinate calcium phosphorus balance, suppression
Fluorine poisoning disease processed.
Calcium hydroxide：Slightly solubility can be formed with the fluoride of more than 10mg/Kg in more than 10mg/Kg in feed or drinking-water
Calcirm-fluoride.Improve the discharge of excrement fluoride.Local weakly alkaline environment is provided for calcium hydroxy phosphate, promotes calcium hydroxy phosphate and fluorine
Combination.Calcium source is provided for body, suppresses fluorine poisoning disease.
Therefore, compared with prior art, the mixture of present invention prevention beaver rabbit fluorine disease, prevention can be played and alleviate by having
The purpose of high fluorine beaver rabbit fluorine poisoning disease, and the quality of beaver rabbit weightening and hide is not interfered with, the advantages of not being detrimental to health.
Embodiment
Embodiment 1：
A kind of mixture for preventing beaver rabbit fluorine disease of the present embodiment, is made up of the raw material of following parts by weight：
0.2 part of calcium selenite, 0.1 part of calcium hydroxy phosphate, 10 parts of calcium hydroxide, 90 parts of calcium gluconate；
By above-mentioned raw materials conventionally, first by 0.2 part of calcium selenite, 0.1 part of calcium hydroxy phosphate, 10 parts of calcium hydroxide
After well mixed, then with calcium gluconate 90 parts be well mixed again, mixture is made.
The specifically used method of the present invention is, in feeding material and drinking-water respectively according to beaver rabbit feed：Mixture=99：1；
Drinking-water：Mixture=99：1 ratio is put into the mixture.
Embodiment 2：
A kind of mixture for preventing beaver rabbit fluorine disease of the present embodiment, is made up of the raw material of following parts by weight：
0.1 part of calcium selenite, 0.1 part of calcium hydroxy phosphate, 18 parts of calcium hydroxide, 82 parts of calcium gluconate；
By above-mentioned raw materials conventionally, first by 0.2 part of calcium selenite, 0.1 part of calcium hydroxy phosphate, 10 parts of calcium hydroxide
After well mixed, then with calcium gluconate 90 parts be well mixed again, mixture is made.
The specifically used method of the present invention is, in feeding material and drinking-water respectively according to beaver rabbit feed：Mixture=99：1；
Drinking-water：Mixture=99：1 ratio is put into the mixture.
Embodiment 3：
A kind of mixture for preventing beaver rabbit fluorine disease of the present embodiment, is made up of the raw material of following parts by weight：
0.15 part of calcium selenite, 0.08 part of calcium hydroxy phosphate, 15 parts of calcium hydroxide, 85 parts of calcium gluconate；
By above-mentioned raw materials conventionally, first by 0.2 part of calcium selenite, 0.1 part of calcium hydroxy phosphate, 10 parts of calcium hydroxide
After well mixed, then with calcium gluconate 90 parts be well mixed again, mixture is made.
The specifically used method of the present invention is, in feeding material and drinking-water respectively according to beaver rabbit feed：Mixture=99：1；
Drinking-water：Mixture=99：1 ratio is put into the mixture.
In order to show nontoxic inventive mixture and effect, effect, the present invention has done following experiment：
Toxicity test of the present invention
Beaver rabbit age in days 30 ± 5 days, 1.1 ± 0.2Kg of body weight, quantity 70, male and female half and half, body weight and health degree are used in experiment
Unanimously.
Feeding management
The daily ration of experimental period supply beaver rabbit, which is divided into basal diet, includes coarse fodder and fine fodder, and coarse fodder is hay or green forage,
Fine fodder is formulated by raw materials such as wheat bran, corn and soybean, and raising 8 days was adapted to before on-test.Start to test after rabbit group is stable,
Perfusion daily 1 time, 8:Completed before 00.
Test method
70 beaver rabbits are divided into 7 groups, beaver rabbit body weight is without significant difference (＞ 0.05) between each group, wherein two groups gavage this mixing
Thing, dosage are 10g/kg, and remaining 5 groups with 10 times of poor determinations, 5 dosage：10g/kg、1g/kg、0.1g/kg、0.01g/kg、
0.001g/kg, test process 96 hours, through test of many times, determine that 100% lethal dose (g/kg) and maximum endure dosage (g/
Kg), according to the concentration waited between contrast spacing method calculating each group.
R is adjacent sets dose ratio in formula；A is that maximum endures dosage；The lethal doses of b 100%, n are group number, then each group
Dosage is respectively a*r, a*r*r ... b.
Computational methods
LD50, the following LgLD50=Xm-d of formula (Σ p-0.5) are calculated using karber's method
Xm is the common logarithm of dead group maximum dose level；The difference of d concentration common logarithms between adjacent sets；P is each group animal
The death rate, decimally represent；Σ p are each group death rate summation.As a result such as table 1：
The death rate and half lethal dose of the mix preparation of table 1 to beaver rabbit
| Group | Dosage g/kg | Sample number | Death rate % | LD50g/kg |
| Embodiment 2 matches mixture group | 10 | 10 | 0 | - |
| Embodiment 3 matches mixture group | 10 | 10 | 0 | - |
| Embodiment 1 matches mixture group | 10 | 10 | 0 | - |
| Embodiment 1 matches mixture group | 1 | 10 | 0 | - |
| Embodiment 1 matches mixture group | 0.1 | 10 | 0 | - |
| Embodiment 1 matches mixture group | 0.01 | 10 | 0 | - |
| Embodiment 1 matches mixture group | 0.001 | 10 | 0 | - |
Each group beaver rabbit does not occur the phenomena of mortality in experimentation, can not obtain half lethal dose, and this product belongs to peace
Full non-harmful product.According to GB 15193.3-1994《National Standard of the People's Republic of China's acute toxicity test》, dosage reaches
10g/kg body weight does not cause animal dead still, you can stopping more frequently being given again, and it can be seen from Appendix D, the present invention is mixed
Compound belongs to actual nontoxic rank.
Anti- fluorine disease contrast test
Test site and time
Test site is in Yuncheng Yuncheng agricultural professional technique institute animal and veterinary experiment Training Room, test period
It is divided into two stages, the pilot study time is 8 days, and the formal test time is 120 days.
Experimental animal
Beaver rabbit age in days 30 ± 5 days, 1.1 ± 0.2Kg of body weight is tested, quantity 40, male and female half and half, is bought in Shanxi Province Yuncheng
City Linyi County Yan Jiazhuan townshiies Nan Dian villages beaver rabbit raiser.In the purchasing process of beaver rabbit, pay special attention to the beaver rabbit uniformity.
Test daily ration
The daily ration of experimental period supply beaver rabbit is divided into coarse fodder and fine fodder, and coarse fodder is hay or green forage, and fine fodder is by wheat bran, jade
The raw material such as rice and soybean is formulated.Water way is free water.According to standard GB/T 7484-87《Water quality fluoride
Measure》Method detects, and the fluorinated volume of water is 0.45mg/Kg, and water source quality reaches Drinking Water in China standard.Daily ration is marked according to country
Quasi- GB/T 5009.18-2003《The measure of national food safety standard food fluorine》Method detects, and the fluorinated volume of feed is 5mg/
Kg, feeding quality reach food security standard.Water is low with feed fluorinated volume, and is substantially carried out contrast and considers, can be neglected drinking-water and
Influence of the fluorine element to experiment in feed.
Test feeding management
Experiment beaver rabbit uses single cage feeding manner.Higher and drier, the nice and cool place cultivation of test site selection, in favor of otter
Rabbit health, reduces test error.In 8 days of pilot study, the health status of beaver rabbit is observed, rejects unhealthy beaver rabbit in time.Often
It early 7：Before 00 does not feed, according to the weight when fluorine agent addition quantity in the sky and water.3 supplies of each group daily ration point, early 7：00th, the noon
13:00th, evening 19：00.During experiment, the cleaning of rabbit home internal and external environment is kept with quiet, periodically sterilization.To reduce the interference of experiment
Factor, experiment feeding process do not give curative drug without any vaccine injection (except sterilization, sterilization fluorine agent).
Test packet design
It is Normal group (negative control group) to test one group.
Test two groups of (positive poisoning control group) every beaver rabbits and supply 15mg/Kg/d (if the Kg in unit mg/Kg/d is not added with
Illustrating all to represent beaver rabbit body weight unit) sodium fluoride is soluble in water drinks, it is necessary to and the same day all drinks.
Test three groups (1 mixtures of embodiment+poisoning), add 1% embodiment 1 proportioning preparation in fine fodder and drinking-water respectively,
Well mixed, 15mg/Kg/d sodium fluorides are soluble in water drinks for every beaver rabbit supply.
Test four groups (mixtures of embodiment 1), add 1% embodiment 1 proportioning preparation in fine fodder and drinking-water respectively.
Data processing
Test data is tabulated with Microsoft Office Excel2007, carries out initial analysis, then use SPSS
(Statistic Program for Social Science) vl7.0 solves related average and standard error, the level of signifiance
Under conditions of 0.05, for group difference Duncan ' s Multiple range tests.
As a result, whole experimental stage, do not occur beaver rabbit death symptom.Test data measurement result such as table 2：
Table 2 tests the 120th day fluorine disease characteristic measurement result (X scholar SD)
| Group | n | 120d urine fluorine (mg/L) | 120d den tal fluorosis rates | 1d original body mass (Kg) | 120d body weight (Kg) | Rate of body weight gain |
| Test one group | 10 | 10.046±3.217a | 0 | 1.112±0.020a | 2.600±0.040a | 1.34% |
| Test two groups | 10 | 24.633±6.325b | 100% | 1.118±0.018a | 2.370±0.037b | 1.12% |
| Test three groups | 10 | 43.999±11.930c | 10% | 1.120±0.019a | 2.567±0.049a | 1.29% |
| Test four groups | 10 | 17.944±5.321ab | 0 | 1.109±0.022a | 2.674±0.030c | 1.41% |
Note：1st, data represent that 2, same file has different alphabetical person's significant difference (p in the form of X scholar SD in table<0.05)
From table 2 it can be seen that the 3rd group of urine row's fluorine amount highest, illustrates that this mix preparation makes fluorine quickly discharge, has
The internal fluorine accumulation of effect alleviation, the 4th group and the not notable (p of second group of difference>0.05), illustrate that healthy beaver rabbit body eats this mixing
An excess amount of fluorine will not be discharged after preparation.
3rd group of den tal fluorosis rate is significantly less than second group, absolutely proves that inventive mixture resists den tal fluorosis significant effect.
3rd group of 120 days body weight and rate of body weight gain are more than second group, illustrate that this mixture improves fluorine disease beaver rabbit body weight effect and shown
Write.
4th group of 120 days body weight and rate of body weight gain are more than first group, illustrate that this mixture can promote non-fluorine disease beaver rabbit body weight to increase
Add.
Claims (1)
1. a kind of mixture for preventing beaver rabbit fluorine disease, it is characterized in that：It is made up of the raw material of following parts by weight：
0.1~0.2 part of calcium selenite, 0.05~0.1 part of calcium hydroxy phosphate, 5~18 parts of calcium hydroxide, calcium gluconate 82~95
Part；
By above-mentioned raw materials conventionally, first by 0.1~0.2 part of calcium selenite, 0.05~0.1 part of calcium hydroxy phosphate, hydrogen-oxygen
Change 5~18 parts of calcium it is well mixed after, then with calcium gluconate 82~95 parts be well mixed again, mixture is made.
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|---|---|---|---|---|
| CN1088758A (en) * | 1992-12-26 | 1994-07-06 | 包钢民用建筑工程部 | A kind of anti-fluorine nutrition liquid and preparation technology thereof |
| US6372198B1 (en) * | 2000-09-14 | 2002-04-16 | Joseph M. Abbate | Dentifrice for the mineralization and remineralization of teeth |
| CN103317811A (en) * | 2013-07-02 | 2013-09-25 | 无锡吉兴汽车部件有限公司 | Production technology for manufacturing soft layer sound insulation pad and hard layer sound insulation pad by utilizing high-temperature steam |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9724542B2 (en) * | 2012-10-12 | 2017-08-08 | Premier Dental Products Company | Remineralizing and desensitizing compositions, treatments and methods of manufacture |
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|---|---|---|---|---|
| CN1088758A (en) * | 1992-12-26 | 1994-07-06 | 包钢民用建筑工程部 | A kind of anti-fluorine nutrition liquid and preparation technology thereof |
| US6372198B1 (en) * | 2000-09-14 | 2002-04-16 | Joseph M. Abbate | Dentifrice for the mineralization and remineralization of teeth |
| CN103317811A (en) * | 2013-07-02 | 2013-09-25 | 无锡吉兴汽车部件有限公司 | Production technology for manufacturing soft layer sound insulation pad and hard layer sound insulation pad by utilizing high-temperature steam |
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