CN105079149A - Application of Xiaojin Pills in preparation of medicine treating multiple myeloma - Google Patents
Application of Xiaojin Pills in preparation of medicine treating multiple myeloma Download PDFInfo
- Publication number
- CN105079149A CN105079149A CN201510550650.8A CN201510550650A CN105079149A CN 105079149 A CN105079149 A CN 105079149A CN 201510550650 A CN201510550650 A CN 201510550650A CN 105079149 A CN105079149 A CN 105079149A
- Authority
- CN
- China
- Prior art keywords
- multiple myeloma
- xiaojin
- application
- preparation
- xiaojin wan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to a new usage of a traditional Chinese medicine product, in particular to application of Xiaojin Pills in preparation of medicine treating multiple myeloma. Through influence of the oral administration of Xiaojin Pills on action of multiple myeloma of mice, the Xiaojin Pills can obviously inhibit growth of a mice multiple myeloma solid tumor. The Xiaojiwan can serve as a medicine treating multiple myeloma.
Description
Technical field
The invention belongs to scope of medicine field, relate to the novelty teabag of tcm product, the particularly application of XIAOJIN WAN in treatment multiple myeloma.
Background technology
Multiple myeloma (multiplemyeloma, MM) be the plasmacytic malignant tumor of a kind of common blood system, with the Clonal hypertrophy of malignant plasma cell in Bone Marrow of Patients for feature, 10% is accounted in hematopoietic neoplasm, can cause organs functional lesion, main manifestations has bone destruction, anemia, infection, renal function injury etc., and most of patients can produce osteolytic lesion and popularity osteoporosis, i.e. Myeloma bone disease (myelomabonedisease, MBD).This disease is hypercalcemia, osteodynia, compression fracture, pathologisch Bruch and nerve compression syndrom because bone marrow destruction causes, is one of common complication of MM.The quality of life of patient can be had a strong impact on, even threaten survival of patients.
XIAOJIN WAN (capsule, sheet) is derived from traditional classical prescription XIAOJIN DAN, the party is loaded in Wang Hongxu " Waike Zhengzhi Quansheng Ji, Life-saving Manual of Diagnosis and Treatment of External Diseases " clearly, former side is made up of Resina Liquidambaris, Radix Aconiti Kusnezoffii, Oletum Trogopterori, Pheretima, Semen Momordicae, Olibanum, Myrrha, Radix Angelicae Sinensis, Moschus, charcoal, carry according to former secretary, clinical in diseases such as " multiple abscess, sucutaneous nodule, scrofula, breast carcinoma, bubo, suppurative osteomyelitis over Huantiao point ".Because its clinical efficacy is better, researches and develops according to this side, gone on the market the Chinese patent medicine of the multiple dosage forms such as multiple ball, capsule, sheet.Wherein XIAOJIN WAN is recorded in Chinese Pharmacopoeia one, be made up of artificial Moschus, Semen Momordicae (shell and deoil), Radix Aconiti Kusnezoffii Preparata, Resina Liquidambaris, Olibanum (system), Myrrha (processed), Oletum Trogopterori (vinegar stir-fry), Radix Angelicae Sinensis (processed with wine), Pheretima and XIANGMO(sic), its function cures mainly as mass dissipating and swelling eliminating, blood-activating analgetic, clinically to stagnate caused scrofula, goiter, breast carcinoma, nodules of the breast for mental disorder, disease sees lump one or several places under skin or skin, and what push away is active, or bone and osteoarthritis, color of the leather is constant, swells and firmly has a pain.
Summary of the invention
The invention provides a kind of new therapeutic use, particularly XIAOJIN WAN application in treatment multiple myeloma of XIAOJIN WAN.
The present invention's medicine XIAOJIN WAN used belongs to prior art, commercially can buy and obtain.
Application of the present invention is that XIAOJIN WAN can suppress multiple myeloma tumor volume growth.
Application of the present invention is that XIAOJIN WAN can suppress multiple myeloma tumor weight to grow.
Creativeness of the present invention is first XIAOJIN WAN is being used for the treatment of the application in multiple myeloma, and therapeutic effect is better.
It is subcutaneous that the present invention is injected to mice after utilizing the myeloma cell strain MPC-11 In vitro culture with Mus homology, form local bone marrow struma block, enough build myeloma core tumor mouse model, give the XIAOJIN WAN Drug therapy of variable concentrations simultaneously, detect XIAOJIN WAN to the growth inhibited effect of mice multiple myeloma solid tumor.The present invention shows that XIAOJIN WAN can treat multiple myeloma.In addition, XIAOJIN WAN have take with easy to carry, can the advantage of long-term taking, so XIAOJIN WAN can be effective to treat multiple myeloma.
Detailed description of the invention
For a better understanding of the present invention, below by XIAOJIN WAN on the inhibiting impact of mice multiple myeloma, its novelty teabag in pharmaceutical field is described, below experiment is intended to further illustrate the present invention but not limitation of the present invention.
embodiment XIAOJIN WAN is to mice multiple myeloma function influence
One, experimental technique
1. the cultivation of myeloma cell strain
Preparation containing 10% horse serum and the high sugared culture fluid of the dual anti-DMEM of 1% penicillin and streptomycin for subsequent use, in experiment, MPC-11 cell is seeded to 50ml culture bottle by 4 × 105/mL concentration, every bottle graft kind cell suspension 7ml, and 37 DEG C of constant temperature culture are in CO2 constant incubator, 2d changes liquid, the centrifugal 5min of 3-4 days, 800rpm, abandons supernatant, go down to posterity according to 1:3, after going down to posterity through 3-4 time, medullary cell is for modeling.
2. the foundation of myeloma mouse subcutaneous model
Subcutaneous in 60 right side of mice armpits for modeling containing the pallium cell injection of 1x107 MPC-11 myeloma cell by every 100ul, continue to raise, after 2-3 days, when armpit lump is visible, carry out tumor stereometry.
3. animal grouping and administration
Model group: gavage gives normal saline, 0.1ml/10g, once a day, continuous 10 days;
Positive drug group: gavage gives capecitabine drug solution (375mg/kg), once a day, continuous 10 days;
XIAOJIN WAN group: gavage give XIAOJIN WAN high (6.24g/kg), in (3.12g/kg), low (0.78g/kg) dose drug solution, once a day, continuous 10 days.
Experimental result represents with mean ± standard deviation (± s), compares and adopt t inspection between group.There were significant differences for P<0.01.
Two, experimental result
The table 1 XIAOJIN WAN different dosing time is on the impact of mouse myeloma volume
Note: compared with model group, * *, P<0.01, *, p<0.05;
Table 2 XIAOJIN WAN is on the impact of mouse bone marrow cells tumor weight
Note: compared with model group, * *, P<0.01, *, p<0.05;
Table 1 and table 2 show, XIAOJIN WAN significantly can suppress the growth (P<0.01) of mouse myeloma solid tumor, high (6.24g/kg), in (3.12g/kg), low (0.79/kg) dosage tumour inhibiting rate be respectively 51.31%, 48.15%, 34.16%, capecitabine tumour inhibiting rate is 63.00%.Therefore, XIAOJIN WAN may be used for treating multiple myeloma, and effect is better.
Claims (3)
1. the application of XIAOJIN WAN in preparation treatment multiple myeloma medicine.
2. application according to claim 1, is characterized in that described application is that XIAOJIN WAN can suppress multiple myeloma tumor volume growth.
3. application according to claim 1, is characterized in that described application is that XIAOJIN WAN can suppress multiple myeloma tumor weight to grow.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510550650.8A CN105079149A (en) | 2015-09-01 | 2015-09-01 | Application of Xiaojin Pills in preparation of medicine treating multiple myeloma |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510550650.8A CN105079149A (en) | 2015-09-01 | 2015-09-01 | Application of Xiaojin Pills in preparation of medicine treating multiple myeloma |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105079149A true CN105079149A (en) | 2015-11-25 |
Family
ID=54561080
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510550650.8A Pending CN105079149A (en) | 2015-09-01 | 2015-09-01 | Application of Xiaojin Pills in preparation of medicine treating multiple myeloma |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105079149A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105816566A (en) * | 2016-05-11 | 2016-08-03 | 丽水市人民医院 | Traditional Chinese medicine formula used for multiple myeloma patients and preparation method thereof |
| CN106075046A (en) * | 2016-07-31 | 2016-11-09 | 孙书芳 | A kind of Chinese medicine treating liver-kidney yin deficiency multiple myeloma |
-
2015
- 2015-09-01 CN CN201510550650.8A patent/CN105079149A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105816566A (en) * | 2016-05-11 | 2016-08-03 | 丽水市人民医院 | Traditional Chinese medicine formula used for multiple myeloma patients and preparation method thereof |
| CN106075046A (en) * | 2016-07-31 | 2016-11-09 | 孙书芳 | A kind of Chinese medicine treating liver-kidney yin deficiency multiple myeloma |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103816280B (en) | Traditional Chinese medicine composition for treating myocardial infarction and application of traditional Chinese medicine composition | |
| TWI598104B (en) | Use of Antrodia cinnamomea extract to improve side effects of chemotherapy | |
| CN105079149A (en) | Application of Xiaojin Pills in preparation of medicine treating multiple myeloma | |
| CN101933963B (en) | Nasal in-situ gel for treating headache | |
| US8722109B1 (en) | Composition comprising plant extracts and essential oils | |
| CN104815038B (en) | A kind of external-applied ointment for acupuncture therapy | |
| CN101574388A (en) | Cordyceps oral solution and preparation method thereof | |
| CN105079151A (en) | Application of Xiaojin pills to preparation of drugs for treating cervical cancer | |
| CN104922456A (en) | Traditional Chinese medicine composition for treating anemia after tumor chemotherapy | |
| CN105079150A (en) | Application of Xiaojin pills to preparation of drugs for treating breast cancer | |
| CN101664436A (en) | Chinese medicinal liniment for treating vitiligo | |
| CN104645177A (en) | Traditional Chinese medicine composition for treating flat wart | |
| EP2402021A1 (en) | Pharmaceutical composition for treating or releiving inflammatory bowel disease | |
| CN102846668A (en) | Preparation method for nanometer Periplaneta americana | |
| CN102580004B (en) | Chinese medicinal composition for treating male erectile dysfunction | |
| CN101991645A (en) | Preparation for treating coronary heart disease and preparation method thereof | |
| CN107929344B (en) | Lithospermum compound composition for preventing and treating laryngeal cancer | |
| CN1297303C (en) | Tumor eliminating powder | |
| CN106963924A (en) | A kind of Chinese medicine preparation of anticancer analgesic and preparation method thereof | |
| CN105343454A (en) | Traditional Chinese medicinal capsule for treating thrombus, and preparation method thereof | |
| CN106366080A (en) | Anti-melanoma compound and application thereof | |
| Xie et al. | Experimental study on acute toxicity of Qingnao tablet to mice | |
| CN104800193A (en) | Pharmaceutical use of guaiol | |
| CN102973607A (en) | Application of pulse and blood improving preparation and leech in preparing medicament for treating sexual dysfunction | |
| CN103142676A (en) | Bone setting blood stasis dispersing muscle tissue regeneration pill |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20151125 |
|
| WD01 | Invention patent application deemed withdrawn after publication |