CN105055742A - Stagnation-relieving and tendon-relaxing pill for treating rheumatoid arthritis and preparation method of stagnation-relieving and tendon-relaxing pill - Google Patents
Stagnation-relieving and tendon-relaxing pill for treating rheumatoid arthritis and preparation method of stagnation-relieving and tendon-relaxing pill Download PDFInfo
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Abstract
The invention discloses a stagnation-relieving and tendon-relaxing pill for treating rheumatoid arthritis and a preparation method of the stagnation-relieving and tendon-relaxing pill. In parts by weight, the stagnation-relieving and tendon-relaxing pill is mainly prepared from the following raw materials: 380-420 parts of processed semen strychni, 80-150 parts of earthworm, 100-150 parts of pseudo-ginseng, 100-150 parts of rhizoma corydalis processed with vinegar, 100-150 parts of dragon's blood, 60-100 parts of agilawood, 120-180 parts of angelica, 60-100 parts of cassia twig, 120-160 parts of rhizoma cibotii, 100-150 parts of incised notopterygium and 100-150 parts of radix angelicae pubescentis. The full prescription of the medicine disclosed by the invention mainly aims at relaxing tendons, activating collaterals and relieving pain, and focuses on relieving pain in limbs and joints caused by stagnation of channels and collaterals; in addition, the medicine throughout persists on means of promoting blood circulation and removing stasis, nourishing liver and kidney, dispelling wind and eliminating dampness, so as to combine reinforcement and elimination, treat both symptoms and root causes and hit pathogenesis. On treating rheumatoid arthritis, the stagnation-relieving and tendon-relaxing pill disclosed by the invention is free from side effect and is significant in treatment effect, and total effective rate reaches 94.0%.
Description
Technical field
The present invention relates to technical field of Chinese medicines, particularly relate to a kind of blood stasis dispelling Shenjin pill for the treatment of rheumatoid arthritis and preparation method thereof.
Background technology
Rheumatoid arthritis is the chronic systemic inflammation disease that a kind of cause of disease not yet understands, for main clinical manifestation, belongs to autoimmune inflammatory disease with pathological changes outside chronic, symmetry, many synovial jointss inflammation and joint.This disease is apt to occur in the Minor articulus such as hands, wrist, foot, and recurrent exerbation, is symmetric.Having joint red and swollen heat pain and dysfunction in early days, can there is stiff deformity in various degree in advanced joint, and with the atrophy of bone and bones flesh, very easily disables.From the angle of pathological change, rheumatoid arthritis mainly involves synovium of joint (later can feed through to articular cartilage, osseous tissue, articular ligament and flesh key), is secondly the popularity diseases associated with inflammation of the connective tissues such as serous coat, the heart, lung and eye.The systemic manifestation of rheumatoid arthritis, except arthropathy, also has heating, fatigue and weak, pericarditis, subcutaneous nodule, pleuritis, arteritis, peripheral neuropathy etc.Age of onset is many at 20 ~ 40 years old, and women is more than male.Primary disease disability rate is high, and doctor trained in Western medicine is difficult to radical cure, does not have specific medicament.So the development in recent years for the Chinese patent medicine of rheumatoid arthritis more and more receives much attention.
At present, for the treatment of rheumatoid arthritis, often there is no suitable mode.In the last few years, also there were many TCM investigation personnel to do certain research to its treatment, also had relevant bibliographical information.Such as: 1, application number is 201510127145.2, name is called the application for a patent for invention of " a kind of Chinese medicine for the treatment of rheumatoid arthritis ", and Chinese medicine disclosed in this application is made up of Radix Gentianae Macrophyllae, Herba Pyrolae, Herba Ephedrae, Bombyx Batryticatus, Semen Coicis, Radix Clematidis, Rhizoma Corydalis, Pheretima (parched), Caulis Piperis Kadsurae, Eupolyphaga Seu Steleophaga, Scorpio, Radix Achyranthis Bidentatae, Radix Astragali, wine Radix Paeoniae Alba, Radix Aconiti Preparata, Radix Paeoniae Rubra.2, application number is 201410726098.9, name is called the application for a patent for invention of the prescription of rheumatoid arthritis " treatment ", and prescription disclosed in this application is prepared from by Pheretima, Nidus Vespae, Scorpio, Agkistrodon and Zaocys.
Summary of the invention
The technical problem to be solved in the present invention is: provide a kind of blood stasis dispelling Shenjin pill for the treatment of rheumatoid arthritis and preparation method thereof.Utilize blood stasis dispelling Shenjin pill of the present invention to treat rheumatoid arthritis, its treatment does not have toxic and side effects, and therapeutic effect is remarkable, and total effective rate reaches 94.0%.
In order to solve the problem, the technical solution used in the present invention is:
The invention provides a kind of blood stasis dispelling Shenjin pill for the treatment of rheumatoid arthritis, represent with weight portion, described blood stasis dispelling Shenjin pill is made primarily of crude drug Semen Strychni (processed) 380 ~ 420 parts, Pheretima 80 ~ 150 parts, Radix Notoginseng 100 ~ 150 parts, vinegar Rhizoma Corydalis 100 ~ 150 parts, Sanguis Draxonis 100 ~ 150 parts, Lignum Aquilariae Resinatum 60 ~ 100 parts, Radix Angelicae Sinensis 120 ~ 180 parts, Ramulus Cinnamomi 60 ~ 100 parts, Rhizoma Cibotii 120 ~ 160 parts, Rhizoma Et Radix Notopterygii 100 ~ 150 parts and Radix Angelicae Pubescentis 100 ~ 150 parts.
According to the blood stasis dispelling Shenjin pill of above-mentioned treatment rheumatoid arthritis, described blood stasis dispelling Shenjin pill is made primarily of crude drug Semen Strychni (processed) 390 ~ 410 parts, Pheretima 100 ~ 120 parts, Radix Notoginseng 110 ~ 130 parts, vinegar Rhizoma Corydalis 120 ~ 130 parts, Sanguis Draxonis 110 ~ 130 parts, Lignum Aquilariae Resinatum 75 ~ 90 parts, Radix Angelicae Sinensis 140 ~ 160 parts, Ramulus Cinnamomi 70 ~ 90 parts, Rhizoma Cibotii 130 ~ 150 parts, Rhizoma Et Radix Notopterygii 120 ~ 140 parts and Radix Angelicae Pubescentis 110 ~ 135 parts.
In addition, provide a kind of preparation method for the treatment of the blood stasis dispelling Shenjin pill of rheumatoid arthritis, described preparation method comprises the following steps:
A, take various crude drug according to the proportioning raw materials of above-mentioned blood stasis dispelling Shenjin pill, first various crude drug is pulverized respectively, cross 100 mesh sieves, by the various crude drug mix homogeneously after pulverizing, obtain mixing fine powders;
B, then add the ratio of starch 23 ~ 28g, microcrystalline Cellulose 1.5 ~ 2.0g successively according to every 1000g mixing fine powders, add starch, microcrystalline Cellulose mix homogeneously, the ratio adding 380 ~ 420g according to every 1000g mixing fine powders after mixing adds water, stirs and makes soft material after 20 ~ 30 minutes;
C, the soft material made by step b are placed in pellet processing machine and make the wet ball that diameter is 4.0 ~ 4.3mm;
D, that the ball that to be wet by step c gained is placed in microwave drying sterilization case is dry, dry ball moisture content≤8% of gained after dry;
E, dry for steps d gained ball is placed in coating pan bag charcoal clothing, polishing, obtains the blood stasis dispelling Shenjin pill of product treatment rheumatoid arthritis.
According to the preparation method of the blood stasis dispelling Shenjin pill of above-mentioned treatment rheumatoid arthritis, add starch 26g respectively according to every 1000g mixing fine powders in step b, the ratio of microcrystalline Cellulose 1.8g adds starch, microcrystalline Cellulose mix homogeneously;
The ratio adding water 400g according to every 1000g mixing fine powders in step b adds water.
The medicine that the present invention treats rheumatoid arthritis also can conventionally be brewed into decoction and take.
the pharmacological action of the various crude drug of the present invention:
Semen Strychni (processed): Semen Strychni (processed) is the dry mature seed of loganiaceae plant S. pierriana.The main component of Semen Strychni is strychnine, has the effect of reduction " erythrocyte sedimentation rate " and " anti-O " clinically.
Semen Strychni (processed) promoting blood circulation to remove obstruction in the collateral, pain relieving, wind-damp dispelling, have antiphlogistic antibacterial effect, expelling the stasis for the new effect.
Semen Strychni: bitter in the mouth, cold in nature, nontoxic; There is the effect such as removing obstruction in the collateral to relieve pain, dispersing swelling and dissipating binds.Removing obstruction in the collateral to relieve pain: by dispelling the wind and dampness pathogens insensitive impediment or contracture numbness; Dispersing swelling and dissipating binds: with controlling wound pain caused by ecchymoma and ulcer sore pain; Treatment poliomyelitis sequela, prolapse of lumbar intervertebral disc, trigeminal neuralgia, rheumatoid arthritis, traumatic injury, congestion pain, anemofrigid-damp arthralgia, general joint contracture, numbness etc.Cure mainly the cards such as throat numbness is logical, ulcer sore pain, migratory arthralgia pain, fracture, facial paralysis and myasthenia gravis.
Pheretima: this taste is micro-salty.Function cures mainly: this product is conventional controls calentura mania and irritation, infantile convulsion, cough with asthma, headache conjunctival congestion, laryngopharynx swelling and pain, urinary obstruction, Fengshi Guanjie pain, the diseases such as hemiplegia.1, clearing heat for calming endogenous wind: cure mainly high fever infantile convulsion, wind symptom is twitched.2, lung-clearing asthma-relieving: the asthma of lung-heat productive cough can be controlled, better to lung heat type bronchial asthma curative effect.3, inducing diuresis for treating stranguria syndrome: be applicable to damp invasion of lower energizer, the puckery pain of pyretic stranguria.4, current meridians: available pyretic arthralgia of controlling saves swollen swelling pain; Suitable compatibility also can control arthralgia due to cold; Compatibility replenishing qi and promoting blood flow medicine is usually used in blood stasis due to qi deficiency, and meridians are unfavorable, aphasia hemiplegia person.
Radix Notoginseng: warm in nature, sweet in the mouth, micro-hardship, nontoxic; Enter liver, stomach, large intestine three warp.Effect: 1, stop blooding dissipating blood stasis: this product kind hemostasis dissipating blood stasis, existing commonly using controls blood disorder, as cards such as metrorrhagia, puerperal blood faints, retention of lochia, traumatic hemorrhage.2, promoting blood circulation and detumescence: this product bitter in the mouth, warm in nature, it is logical that hardship lets out temperature, enters blood system then blood circulation promoting and blood stasis dispelling, detumescence de-swelling, with controlling traumatic injury, unknown carbuncle.3, eliminating stasis to stop pain: this product blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, with controlling pain due to blood stasis, flutters damage pain, the cards such as carbuncle pain, and analgesic efficacy is best.
Rhizoma Corydalis: this product acrid in the mouth, warm in nature, nontoxic; Have invigorate blood circulation, circulation of qi promoting, the effect such as pain relieving; Be usually used in the breast side of body, epigastric pain, obstruction of qi in the chest and cardialgia, amenorrhea dysmenorrhea, postpartum stagnation, tumbling down swells and ache, removing blood stasis, and married woman's menoxenia, lumps in abdomen, and metrorrhagia drenches dew, puerperal all disorders of blood, blood is transported, and sudden and violent blood rushes to, because damaging the card such as hematochezia.
Vinegar Rhizoma Corydalis: this product gets Rhizoma Corydalis 100 kilograms, mixes thoroughly, stew to moisten 2-4 hour, put in medicine cookeding pot with rice vinegar 20 jin, stir-fries to aobvious deep yellow heat color by low baking temperature heat hot, and micro-dry, take out, airing is cool.After vinegar system, increase the dissolubility of medicine in water, and be apt to into Liver Channel, strengthen analgesic effect.
Sanguis Draxonis: this product sweet in the mouth, salty, property is put down; Mild toxicity.GUIXIN warp, Liver Channel.Effect: this product has dissipating blood stasis analgesic therapy, hemostasis, the effects such as promoting tissue regeneration and ulcer healing; Cure mainly traumatic injury, ecchymoma due to internal injury, dysmenorrhea, postpartum stagnation is suffered from abdominal pain, continuous bleeding due to traumatic injury, scrofula, the card such as ecthyma unhealed for long time and hemorrhoid.
Lignum Aquilariae Resinatum: this product acrid in the mouth, hardship, warm in nature; Return spleen, stomach, kidney, lung meridian.Effect: the effects such as this product has sending down the abnormal ascending QI warming middle-JIAO, warming the kidney improving inspiration by invigorating kidney-QI; Cure mainly QI rising in reverse order to pant, vomiting singultus, abdominal distention, waist knee joint cold caused by deficiency, large intestine constipation due to insufficiency, urine qi stranguria, the cards such as man's cold sperm.
Radix Angelicae Sinensis: this product is warm in nature, acrid in the mouth, sweet; Enter the heart, liver, spleen, lung four warp.Effect: 1, nourshing blood and promoting blood circulation: this product sweet in the mouth and weighing, therefore specially can enrich blood, its gas is light and pungent, again can promoting the circulation of blood, and invigorating middle warmer has, and have benefit, the gas medicine in sincere blood in row, the panacea also in blood also.This product is good hematonic, therefore is applicable to the various syndromes that blood deficiency causes.2, promoting blood circulation and stopping pain: Radix Angelicae Sinensis can by congestion, tissue regeneration promoting blood, makes unobstructed vessel and gas walk abreast, flows round without stopping.Be usually used in traumatic injury stasis of blood pain, carbuncle stasis pain, the stagnant stomachache of the stasis of blood in puerperal, rheumatic arthralgia and the card such as meridians are unfavorable, this product has good promoting blood circulation and stopping pain effect.3, nourishing blood for regulating menstruation.4, loosening bowel to relieve constipation: few for blood deficiency Tianjin, dryness of the intestine constipation.Disease is seen: constipation, lusterless complexion, and severe palpitation is had a dizzy spell.5, sending down the abnormal ascending QI cough-relieving: the pungent temperature of Radix Angelicae Sinensis, enters lung meridian, have depressed lung-energy dispersing, the merit of sending down the abnormal ascending QI cough-relieving.6, Radix Angelicae Sinensis should be used for headache due to deficiency of blood and headache due to blood stasis person.Modern pharmacology research proves: it contains the many kinds of substances such as volatile oil, organic acid, aminoacid, vitamin, trace element, significantly can promote body hemopoietic function, raises erythrocyte, leukocyte and content of hemoglobin; Suppress platelet aggregation, antithrombotic, adjusting blood lipid; Resist myocardial ischemia, arrhythmia, blood vessel dilating, reduces blood pressure; Regulate uterine smooth muscle.Immunity, antiinflammatory can also be strengthened, protect the liver, radioprotective, antioxidation and scavenging free radicals etc.
Ramulus Cinnamomi: this product acrid in the mouth, sweet, warm in nature; Return urinary bladder channel, heart channel, lung meridian.Effect: this product has diaphoresis expelling pathogenic factors from muscles, warming the meridian and promoting blood circulation, supporing yang activating QI, the effects such as dispersing cold for relieving pain; Cure mainly exterior syndrome due to wind-cold, arthralgia due to cold-dampnes, extreme cold of the limbs, amenorrhea dysmenorrhea, lump in the abdomen lumps, the thoracic obstruction, cardiopalmus, phlegm retention, the cards such as dysuria.
Rhizoma Cibotii: this product bitter in the mouth, liver, warm in nature; Return liver, kidney channel.Effect: this product has wind-damp dispelling, invigorating the liver and kidney, the effects such as strong waist knee joint; Conventional dispelling the wind and dampness pathogens arthralgia pain, soreness of the waist and knees, weakness of the lower extremities, frequent micturition, the enuresis, the cards such as leukorrhagia.External application incised wound.
Rhizoma Et Radix Notopterygii: this product acrid in the mouth, hardship, warm in nature; Enter bladder, kidney channel.Effect: this product has loose exterior cold, wind-damp dispelling, sharp joint, the effects such as pain relieving; Commonly use and control affection of exogenous wind-cold, have a headache lossless, mimeograph cold-damp numbness, edema due to wind pathogen edema, the cards such as sore swollen toxin; For sexual impotence seminal emission, enuresis frequent micturition, chills and pain of the waist and kness, suffers from a deficiency of the kidney and breathes heavily, Diarrhoea; External curing vitiligo, alopecia areata.
Radix Angelicae Pubescentis: this product acrid in the mouth, hardship, slightly warm in nature; Return liver, kidney, urinary bladder channel.Effect: this product has the effect such as expelling wind and dampness, dispersing cold for relieving pain; Be usually used in anemofrigid-damp arthralgia, lumbocrural pain, few cloudy volt wind headache, the diseases such as headache toothache.
The compatibility mechanism of medicament composing prescription of the present invention: venation numbness type rheumatoid arthritis is the common pattern of syndrome of this disease, and motherland's medical science is thought, it is main pathogenic that positive QI-insufficiency and wind-cold damp pathogen are hurted sb.'s feelings in an opponent's defence, pathogen usually intruding into collateral in protracted disease, the symptoms such as muscle arthrosis pain, appear that meridians are inaccessible, in deficiency of qi and blood.Exopathogen is attacked, weather drastic change, or the ground occupying cold wet for a long time, or paddles in spite of the rain, or exposure to wind when sweating, causes wind-cold damp pathogen to invade human body, notes in meridians, joint muscles and bones of being detained, and QI and blood numbness is hindered and forms podomere numbness disease.Arthromyodynia with the passing of time, positive QI-insufficiency, the unable and stasis blocking of blood, or sense heresy with the passing of time, the heresy cohesion of cold-damp is cold-phlegm, and phlegm-damp is deadlocked sticky, hinders in passages through which vital energy circulates, blood stasis blocking; The expectorant stasis of blood is cementing, and hinder in joint muscles and bones, QI and blood is obstructed, and joint muscles and bones is lost it and moistened foster and cause arthromyodynia.The positive QI-insufficiency of ferritic, weakened defensive QI, affection of exogenous wind-cold damp or wound, strain, cause coagulation of QI-blood, and it is sick that the resistance of venation numbness forms podomere numbness.With relaxing muscles and tendons and activating QI and blood in the collateral in treatment, blood-activating analgetic is method.Medicinal Semen Strychni removing obstruction in the collateral to relieve pain, mass dissipating and swelling eliminating, expelling wind and dampness, bone and muscle strengthening is monarch drug.Ramulus Cinnamomi is pungent, sweet, warm, has warming the meridian arteries and veins, effect of dispersing cold for relieving pain; Rhizoma Et Radix Notopterygii is pungent, bitter, temperature, and induce sweat cold expelling, expelling wind and dampness, pain relieving; Radix Angelicae Pubescentis is pungent, bitter, tepor, wind-damp dispelling, pain relieving.Pheretima tonneau meridians, for rheumatic arthralgia; Be ministerial drug altogether.Radix Notoginseng treating blood disorders dissipating blood stasis, reducing swelling and alleviating pain; Vinegar Rhizoma Corydalis blood circulation promoting and blood stasis dispelling, promoting the circulation of QI to relieve pain, Compendium of Material Medica says it: " stagnation of QI in energy promoting the circulation of blood, stasis in gas, therefore specially control upper and lower all pains all over the body." pain relieving of Sanguis Draxonis promoting blood circulation to remove blood stasis; Lignum Aquilariae Resinatum is pungent, bitter, tepor, function promoting the circulation of QI to relieve pain, the kidney warming improving inspiration by invigorating kidney-QI, " herbal classic is met former " cloud: " all stagnation of QI knots are not stretched person and be shoulded it.Temperature and not dry, row and do not let out ... " Rhizoma Cibotii hardship, sweet, temperature.For wind-damp dispelling, invigorating the liver and kidney, strong waist knee joint is adjuvant altogether.Full presciption medicine card conforms to, and sincerely detain pathogenesis, curative effect is rather good.
Primary disease has mild case, has again and heavily demonstrate,proves, and also has to dislike to wait, so total method be unable to do without.Disease enters network for a long time, therefore in line with the reason tune of " control wind and first control blood, blood wind from go out ".
Total sight is side entirely, and based on relaxing muscles and tendons and activating QI and blood in the collateral pain relieving, focus on the extremities joint pain corrected caused by the resistance of venation numbness, separately carry throughout with the method for blood circulation promoting and blood stasis dispelling, liver and kidney tonifying, expelling wind and removing dampness, reinforcement and elimination in combination, treating both the principal and the secondary aspects of a disease at the same time, hit pathogenesis.
positive beneficial effect of the present invention:
1, utilize blood stasis dispelling Shenjin pill of the present invention to treat rheumatoid arthritis, its treatment does not have toxic and side effects, and therapeutic effect is remarkable, and total effective rate reaches 94.0%.
2, medicament composing prescription of the present invention, based on relaxing muscles and tendons and activating QI and blood in the collateral pain relieving, focus on the extremities joint pain corrected caused by the resistance of venation numbness, separately carry throughout with the method for blood circulation promoting and blood stasis dispelling, liver and kidney tonifying, expelling wind and removing dampness, reinforcement and elimination in combination, treating both the principal and the secondary aspects of a disease at the same time, hit pathogenesis.
3, medicament composing prescription of the present invention with relaxing muscles and tendons and activating QI and blood in the collateral, blood-activating analgetic for primary efficacy; Cure mainly BJM, fascia and other soft tissue pain.
4, blood stasis dispelling Shenjin pill of the present invention creates good Social benefit and economic benefit in 10 years in clinical middle use, solves the misery of the patients such as ankylosing spondylitis, rheumatoid arthritis, skeletal pain, neuralgia.
1) social benefit:
Blood stasis dispelling Shenjin pill is in clinical middle determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, dissolve by the cause of disease, after generally taking medicine 10 days, patients clinical symptom alleviates, pain relief, effectively shortens the treatment time of patient, alleviate the sufferings of patient, the perfect therapeutic scheme of podomere numbness disease, improves the therapeutic effect of primary disease, creates certain social influence and public praise publicity.
2) economic benefit:
Blood stasis dispelling Shenjin pill of the present invention applies to the clinical slight illness efficiently solving most of podomere numbness patient, and dosage form is convenient, and curative effect is given prominence to, economical cheap, patient is easy to accept, and highlights Chinese medicine characteristic simultaneously, facilitate the development of traditional Chinese medical bone fracture disease, also create certain economic benefit.
3) potential benefit:
Ankylosing spondylitis, rheumatoid arthritis are orthopedics department difficult disease, inquire into by the clinical observations of nearly 10 years, etiology and pathogenesis and sum up, blood stasis dispelling Shenjin pill of the present invention, if be applied to clinical, will bring glad tidings to numerous patient, the economic benefit also brought to hospital and social benefit.
5, for many years, utilize product blood stasis dispelling Shenjin pill of the present invention to treat rheumatoid arthritis patients many cases, carried out detail statistics to the treatment situation of wherein 500 routine patients, statistics and therapeutic effect thereof refer to table 1, table 2.
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The diagnostic criteria of rheumatoid arthritis:
1, Western medicine diagnose standard (rheumatism association of the U.S. (ARA) diagnostic criteria in 1987):
(1) Diagnosis of Rheumatoid Arthritis standard:
A, morning deadlock at least 1 hour, continued at least 6 weeks.
B, more than 3 or 3 arthritis swelling continued at least 6 weeks.
C, carpal joint, metacarpophalangeal joints or proximal phalangeal joints swelling 6 weeks or more.
D, symmetry arthroncus.
The x-ray photographing of e, hands should have typical rheumatoid arthrosis and changes and must comprise erosion and sclerotin decalcification.
F, rheumatoid nodules.
G, rheumatoid factor positive.
(2) standard is made a definite diagnosis:
Possess above-mentioned 4 can make a definite diagnosis.
Therapeutic Method: rheumatoid arthritis patients is taken the present invention and treated rheumatoid arthritis blood stasis dispelling Shenjin pill Chinese patent medicine pill (namely the present invention treats the Chinese patent medicine of rheumatoid arthritis, and its dosage form is pill), and the prescription of employing is: Semen Strychni (processed) 380
~420 parts, Pheretima 80
~150 parts, Radix Notoginseng 100
~150 parts, vinegar Rhizoma Corydalis 100
~150 parts, Sanguis Draxonis 100
~150 parts, Lignum Aquilariae Resinatum 60
~100 parts, Radix Angelicae Sinensis 120
~180 parts, Ramulus Cinnamomi 60
~100 parts, Rhizoma Cibotii 120
~160 parts, Rhizoma Et Radix Notopterygii 100
~150 parts and Radix Angelicae Pubescentis 100
~150 parts.
The instructions of taking of blood stasis dispelling Shenjin pill of the present invention: 3 times on the one, a 6g, warm water delivery service; It within 30 days, is a course for the treatment of.
Take Chinese patent medicine blood stasis dispelling Shenjin pill criterion of therapeutical effect of the present invention:
1, curative effect of disease criterion:
(1) clinical remission: cardinal symptom disappears substantially, main laboratory indexes recovers normal.
(2) effective: cardinal symptom takes a turn for the better, and main laboratory indexes is tending towards normal.
(3) effective: cardinal symptom makes moderate progress, and main laboratory indexes numerical value declines to some extent.
(4) invalid: not reach above-mentioned effective standard or add severe one.
2, therapeutic effect of syndrome criterion:
(1) clinical recovery: tcm clinical practice symptom, sign disappear or substantially disappear, syndrome integral reduces >=95%.(2) effective: tcm clinical practice symptom, sign are obviously improved, syndrome integral reduces >=70%.
(3) effective: tcm clinical practice symptom, sign all take a favorable turn, syndrome integral reduces >=30%.
(4) invalid: tcm clinical practice symptom, sign are all not improved, even increase the weight of, syndrome integral reduces
Less than 30%.
Note: computing formula (nimodipine point system) is: [before (before treatment the rear integration of integration-treatment) ÷ treatment integration] × 100%.
Utilize blood stasis dispelling Shenjin pill of the present invention to treat the curative effect situation of 500 routine rheumatoid arthritis patients from table 1, table 2, utilize blood stasis dispelling Shenjin pill of the present invention to treat rheumatoid arthritis disease, its therapeutic effect is remarkable, and total effective rate reaches 94.0%.
model case:
1, Lee, female, 49 years old, be chief complaint with " swollen more than 6 years of extremities joint pain companion metacarpophalangeal joints ", existing disease is seen: both hands arthralgia companion partial joint swells and ache, and limited, the right elbow joint flexing of two wrist joints moving 15 degree is stretched can not, dark tongue quality, tongue is white, and corpulent tongue is large, soft and thready pulse.Look into X sheet to show: both hands proximal interphalangeal joint gap is fuzzy; Be diagnosed as " rheumatoid arthritis ".To our hospital upon somebody's introduction, blood stasis dispelling Shenjin pill of the present invention is taken in therapeutic process, the prescription of this pill is: the instructions of taking of Semen Strychni (processed) 400g, Pheretima 150g, Radix Notoginseng 100g, vinegar Rhizoma Corydalis 120g, Sanguis Draxonis 100g, Lignum Aquilariae Resinatum 80g, Radix Angelicae Sinensis 150g, Ramulus Cinnamomi 75g, Rhizoma Cibotii 150g, Rhizoma Et Radix Notopterygii 110g and Radix Angelicae Pubescentis 120g(blood stasis dispelling Shenjin pill: 3 times on the one, a 6g, warm water delivery service; It within 30 days, is a course for the treatment of).This patient take Chinese patent medicine of the present invention (blood stasis dispelling Shenjin pill) treat 2 courses for the treatment of after the both hands metacarpophalangeal joints symptom that swells and ache obviously alleviate.Swell and ache after continuing to take 2 courses for the treatment of of medicine Chinese patent medicine of the present invention (blood stasis dispelling Shenjin pill) disappearance, tcm symptom sign is obviously improved, and now normally works.
2, Zhang, man, 52 years old, is chief complaint with " the right hip activity of companion's hip in 20 years of both hands arthralgia is ached 3 years ", have a medical check-up: both hands mild malformation changes, the swelling of companion's proximal interphalangeal joint, two carpal joint dorsiflexion, the palm are bent limited, and 4 word test right sides are positive, dark tongue quality, tongue is white, and corpulent tongue is large, deep pulse, diagnosis: 1, rheumatoid arthritis 2, right lateral thigh head necrosis.To our hospital upon somebody's introduction, blood stasis dispelling Shenjin pill of the present invention is taken in therapeutic process, the prescription of this pill is: the instructions of taking of Semen Strychni (processed) 380g, Pheretima 90g, Radix Notoginseng 120g, vinegar Rhizoma Corydalis 120g, Sanguis Draxonis 100g, Lignum Aquilariae Resinatum 90g, Radix Angelicae Sinensis 160g, Ramulus Cinnamomi 80g, Rhizoma Cibotii 160g, Rhizoma Et Radix Notopterygii 120g and Radix Angelicae Pubescentis 150g(blood stasis dispelling Shenjin pill: 3 times on the one, a 6g, warm water delivery service; It within 30 days, is a course for the treatment of).This patient take Chinese patent medicine of the present invention (blood stasis dispelling Shenjin pill) treat 2 courses for the treatment of after the both hands metacarpophalangeal joints symptom that swells and ache obviously alleviate, the right hip arthralgia alleviates.Swell and ache after continuing to take 2 courses for the treatment of of medicine Chinese patent medicine of the present invention (blood stasis dispelling Shenjin pill) disappearance, tcm symptom sign is obviously improved, and existing basic living is taken care of oneself.
3, Fan, man, 47 years old, is chief complaint with " both hands joint deformity 9 accompanies right knee joint to swell and ache 4 months ", haves a medical check-up: both hands joint deformity companion limitation of activity, duplex joint flexing 15 degree stretch can not, dark tongue quality, tongue in vain, deep-thready pulse.Right knee joint MRI shows: capsule hydrops on right knee joint endoprosthesis chamber and kneecap.Be diagnosed as in conjunction with both hands joint P-A Cephalomatrics (carrying): rheumatoid arthritis.To our hospital, blood stasis dispelling Shenjin pill of the present invention is taken in therapeutic process, the prescription of this pill is: the instructions of taking of Semen Strychni (processed) 420g, Pheretima 110g, Radix Notoginseng 150g, vinegar Rhizoma Corydalis 120g, Sanguis Draxonis 110g, Lignum Aquilariae Resinatum 98g, Radix Angelicae Sinensis 160g, Ramulus Cinnamomi 90g, Rhizoma Cibotii 120g, Rhizoma Et Radix Notopterygii 150g and Radix Angelicae Pubescentis 120g(blood stasis dispelling Shenjin pill: 3 times on the one, a 6g, warm water delivery service; It within 30 days, is a course for the treatment of).This patient take Chinese patent medicine of the present invention (blood stasis dispelling Shenjin pill) treat 2 the course for the treatment of the right knee joint symptom that swells and ache obviously alleviate.Swell and ache after continuing to take 2 courses for the treatment of of medicine Chinese patent medicine of the present invention (blood stasis dispelling Shenjin pill) disappearance, tcm symptom sign is obviously improved, and now normally works.
4, hole, female, 23 years old, falls ill 3 years, both hands arthralgia companion activity pain, and two wrist joints moving is limited, double knee joint pain, walks lamely, difficulty of squatting down, dark tongue quality, and corpulent tongue is large, white and thin fur, deep-thready pulse.Look into X-ray film to show: both hands joint space is fuzzy, anti-CCP result: 78, CRP:45mg/L; Be diagnosed as " rheumatoid arthritis ".To our hospital upon somebody's introduction, blood stasis dispelling Shenjin pill of the present invention is taken in therapeutic process, the prescription of this pill is: the instructions of taking of Semen Strychni (processed) 410g, Pheretima 120g, Radix Notoginseng 150g, vinegar Rhizoma Corydalis 130g, Sanguis Draxonis 100g, Lignum Aquilariae Resinatum 70g, Radix Angelicae Sinensis 180g, Ramulus Cinnamomi 90g, Rhizoma Cibotii 120g, Rhizoma Et Radix Notopterygii 120g and Radix Angelicae Pubescentis 120g(blood stasis dispelling Shenjin pill: 3 times on the one, a 6g, warm water delivery service; It within 30 days, is a course for the treatment of).This patient take Chinese patent medicine of the present invention (blood stasis dispelling Shenjin pill) treat 2 courses for the treatment of after the both hands metacarpophalangeal joints symptom that swells and ache obviously alleviate, after continuing to take 2 courses for the treatment of of medicine Chinese patent medicine of the present invention (blood stasis dispelling Shenjin pill), double knee joint swells and ache disappearance, tcm symptom sign is obviously improved, and now normally works.
5, Yan, female, 59 years old, is chief complaint with " whole body multi-joint pain 20 years the two wrist joints moving of companion limited 5 years ", haves a medical check-up: both hands deformity changes, flexing position, two wrist joints moving limited duplex joint stretch can not, dark tongue quality, white and thin fur, deep-thready pulse.Look into both hands joint P-A Cephalomatrics to show: refer to that a proximal joint is fuzzy, carpal joint gap turn narrow is diagnosed as " rheumatoid arthritis ".To our hospital upon somebody's introduction, blood stasis dispelling Shenjin pill of the present invention is taken in therapeutic process, the prescription of this pill is: the instructions of taking of Semen Strychni (processed) 420g, Pheretima 100g, Radix Notoginseng 120g, vinegar Rhizoma Corydalis 120g, Sanguis Draxonis 120g, Lignum Aquilariae Resinatum 85g, Radix Angelicae Sinensis 160g, Ramulus Cinnamomi 80g, Rhizoma Cibotii 145g, Rhizoma Et Radix Notopterygii 110g and Radix Angelicae Pubescentis 150g(blood stasis dispelling Shenjin pill: 3 times on the one, a 6g, warm water delivery service; It within 30 days, is a course for the treatment of).This patient take Chinese patent medicine of the present invention (blood stasis dispelling Shenjin pill) treat 2 courses for the treatment of after multi-joint pain symptom obviously alleviate, to swell and ache after continuing to take 2 courses for the treatment of of medicine Chinese patent medicine of the present invention (blood stasis dispelling Shenjin pill) disappearance, tcm symptom sign is obviously improved, and existing basic living is taken care of oneself.
detailed description of the invention:
Set forth the present invention further below in conjunction with embodiment, but do not limit content of the present invention.
Embodiment 1:
The present invention treats the blood stasis dispelling Shenjin pill of rheumatoid arthritis, represent with weight portion, be made up of crude drug Semen Strychni (processed) 400g, Pheretima 150g, Radix Notoginseng 100g, vinegar Rhizoma Corydalis 120g, Sanguis Draxonis 100g, Lignum Aquilariae Resinatum 80g, Radix Angelicae Sinensis 150g, Ramulus Cinnamomi 75g, Rhizoma Cibotii 150g, Rhizoma Et Radix Notopterygii 110g and Radix Angelicae Pubescentis 120g.
Embodiment 2:
The present invention treats the blood stasis dispelling Shenjin pill of rheumatoid arthritis, represent with weight portion, be made up of crude drug Semen Strychni (processed) 380g, Pheretima 90g, Radix Notoginseng 120g, vinegar Rhizoma Corydalis 120g, Sanguis Draxonis 100g, Lignum Aquilariae Resinatum 90g, Radix Angelicae Sinensis 160g, Ramulus Cinnamomi 80g, Rhizoma Cibotii 160g, Rhizoma Et Radix Notopterygii 120g and Radix Angelicae Pubescentis 150g.
Embodiment 3:
The present invention treats the blood stasis dispelling Shenjin pill of rheumatoid arthritis, represent with weight portion, be made up of crude drug Semen Strychni (processed) 420g, Pheretima 110g, Radix Notoginseng 150g, vinegar Rhizoma Corydalis 120g, Sanguis Draxonis 110g, Lignum Aquilariae Resinatum 98g, Radix Angelicae Sinensis 160g, Ramulus Cinnamomi 90g, Rhizoma Cibotii 120g, Rhizoma Et Radix Notopterygii 150g and Radix Angelicae Pubescentis 120g.
Embodiment 4:
The present invention treats the blood stasis dispelling Shenjin pill of rheumatoid arthritis, represent with weight portion, be made up of crude drug Semen Strychni (processed) 410g, Pheretima 120g, Radix Notoginseng 150g, vinegar Rhizoma Corydalis 130g, Sanguis Draxonis 100g, Lignum Aquilariae Resinatum 70g, Radix Angelicae Sinensis 180g, Ramulus Cinnamomi 90g, Rhizoma Cibotii 120g, Rhizoma Et Radix Notopterygii 120g and Radix Angelicae Pubescentis 120g.
Embodiment 5:
The present invention treats the blood stasis dispelling Shenjin pill of rheumatoid arthritis, represent with weight portion, be made up of crude drug Semen Strychni (processed) 420g, Pheretima 100g, Radix Notoginseng 120g, vinegar Rhizoma Corydalis 120g, Sanguis Draxonis 120g, Lignum Aquilariae Resinatum 85g, Radix Angelicae Sinensis 160g, Ramulus Cinnamomi 80g, Rhizoma Cibotii 145g, Rhizoma Et Radix Notopterygii 110g and Radix Angelicae Pubescentis 150g.
Embodiment 6:
The present invention treats the blood stasis dispelling Shenjin pill of rheumatoid arthritis, represent with weight portion, be made up of crude drug Semen Strychni (processed) 420g, Pheretima 85g, Radix Notoginseng 130g, vinegar Rhizoma Corydalis 100g, Sanguis Draxonis 130g, Lignum Aquilariae Resinatum 65g, Radix Angelicae Sinensis 120g, Ramulus Cinnamomi 95g, Rhizoma Cibotii 130g, Rhizoma Et Radix Notopterygii 100g and Radix Angelicae Pubescentis 140g.
Embodiment 7:
The present invention treats the blood stasis dispelling Shenjin pill of rheumatoid arthritis, represent with weight portion, be made up of crude drug Semen Strychni (processed) 390g, Pheretima 80g, Radix Notoginseng 110g, vinegar Rhizoma Corydalis 140g, Sanguis Draxonis 150g, Lignum Aquilariae Resinatum 60g, Radix Angelicae Sinensis 130g, Ramulus Cinnamomi 60g, Rhizoma Cibotii 140g, Rhizoma Et Radix Notopterygii 130g and Radix Angelicae Pubescentis 100g.
Embodiment 8:
The present invention treats the blood stasis dispelling Shenjin pill of rheumatoid arthritis, represent with weight portion, be made up of crude drug Semen Strychni (processed) 410g, Pheretima 140g, Radix Notoginseng 120g, vinegar Rhizoma Corydalis 125g, Sanguis Draxonis 110g, Lignum Aquilariae Resinatum 100g, Radix Angelicae Sinensis 120g, Ramulus Cinnamomi 100g, Rhizoma Cibotii 135g, Rhizoma Et Radix Notopterygii 120g and Radix Angelicae Pubescentis 130g.
Embodiment 9:
The present invention treats the blood stasis dispelling Shenjin pill of rheumatoid arthritis, represent with weight portion, be made up of crude drug Semen Strychni (processed) 420g, Pheretima 95g, Radix Notoginseng 120g, vinegar Rhizoma Corydalis 110g, Sanguis Draxonis 120g, Lignum Aquilariae Resinatum 80g, Radix Angelicae Sinensis 140g, Ramulus Cinnamomi 85g, Rhizoma Cibotii 130g, Rhizoma Et Radix Notopterygii 110g and Radix Angelicae Pubescentis 140g.
Embodiment 10: embodiment of the present invention 1-9 treats the preparation method of rheumatoid arthritis blood stasis dispelling Shenjin pill, and its detailed step is as follows:
A, take various crude drug according to the proportioning raw materials of blood stasis dispelling Shenjin pill described in embodiment 1-9 any embodiment, first various crude drug is pulverized respectively, cross 100 mesh sieves, by the various crude drug mix homogeneously after pulverizing, obtain mixing fine powders;
B, then add the ratio of starch 26g, microcrystalline Cellulose 1.8g successively according to every 1000g mixing fine powders, add starch, microcrystalline Cellulose mix homogeneously, the ratio adding 400g according to every 1000g mixing fine powders after mixing adds water, stirs and makes soft material after 30 minutes;
C, the soft material made by step b are placed in pellet processing machine and make the wet ball that diameter is 4.0 ~ 4.3mm;
D, that the ball that to be wet by step c gained is placed in microwave drying sterilization case is dry, dry ball moisture content≤8% of gained after dry;
E, dry for steps d gained ball is placed in coating pan bag charcoal clothing, polishing, obtains the blood stasis dispelling Shenjin pill of product treatment rheumatoid arthritis.
Claims (4)
1. treat the blood stasis dispelling Shenjin pill of rheumatoid arthritis for one kind, it is characterized in that: represent with weight portion, described blood stasis dispelling Shenjin pill is made primarily of crude drug Semen Strychni (processed) 380 ~ 420 parts, Pheretima 80 ~ 150 parts, Radix Notoginseng 100 ~ 150 parts, vinegar Rhizoma Corydalis 100 ~ 150 parts, Sanguis Draxonis 100 ~ 150 parts, Lignum Aquilariae Resinatum 60 ~ 100 parts, Radix Angelicae Sinensis 120 ~ 180 parts, Ramulus Cinnamomi 60 ~ 100 parts, Rhizoma Cibotii 120 ~ 160 parts, Rhizoma Et Radix Notopterygii 100 ~ 150 parts and Radix Angelicae Pubescentis 100 ~ 150 parts.
2. the blood stasis dispelling Shenjin pill for the treatment of rheumatoid arthritis according to claim 1, is characterized in that: described blood stasis dispelling Shenjin pill is made primarily of crude drug Semen Strychni (processed) 390 ~ 410 parts, Pheretima 100 ~ 120 parts, Radix Notoginseng 110 ~ 130 parts, vinegar Rhizoma Corydalis 120 ~ 130 parts, Sanguis Draxonis 110 ~ 130 parts, Lignum Aquilariae Resinatum 75 ~ 90 parts, Radix Angelicae Sinensis 140 ~ 160 parts, Ramulus Cinnamomi 70 ~ 90 parts, Rhizoma Cibotii 130 ~ 150 parts, Rhizoma Et Radix Notopterygii 120 ~ 140 parts and Radix Angelicae Pubescentis 110 ~ 135 parts.
3. treat a preparation method for the blood stasis dispelling Shenjin pill of rheumatoid arthritis, it is characterized in that, described preparation method comprises the following steps:
A, take various crude drug according to the proportioning raw materials of blood stasis dispelling Shenjin pill described in claim 1 or 2, first various crude drug is pulverized respectively, cross 100 mesh sieves, by the various crude drug mix homogeneously after pulverizing, obtain mixing fine powders;
B, then add the ratio of starch 23 ~ 28g, microcrystalline Cellulose 1.5 ~ 2.0g successively according to every 1000g mixing fine powders, add starch, microcrystalline Cellulose mix homogeneously, the ratio adding 380 ~ 420g according to every 1000g mixing fine powders after mixing adds water, stirs and makes soft material after 20 ~ 30 minutes;
C, the soft material made by step b are placed in pellet processing machine and make the wet ball that diameter is 4.0 ~ 4.3mm;
D, that the ball that to be wet by step c gained is placed in microwave drying sterilization case is dry, dry ball moisture content≤8% of gained after dry;
E, dry for steps d gained ball is placed in coating pan bag charcoal clothing, polishing, obtains the blood stasis dispelling Shenjin pill of product treatment rheumatoid arthritis.
4. treat the preparation method of the blood stasis dispelling Shenjin pill of rheumatoid arthritis according to claim 3, it is characterized in that: add starch 26g respectively according to every 1000g mixing fine powders in step b, the ratio of microcrystalline Cellulose 1.8g adds starch, microcrystalline Cellulose mix homogeneously;
The ratio adding water 400g according to every 1000g mixing fine powders in step b adds water.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510452951.7A CN105055742A (en) | 2015-07-29 | 2015-07-29 | Stagnation-relieving and tendon-relaxing pill for treating rheumatoid arthritis and preparation method of stagnation-relieving and tendon-relaxing pill |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510452951.7A CN105055742A (en) | 2015-07-29 | 2015-07-29 | Stagnation-relieving and tendon-relaxing pill for treating rheumatoid arthritis and preparation method of stagnation-relieving and tendon-relaxing pill |
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| CN105055742A true CN105055742A (en) | 2015-11-18 |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1280846A (en) * | 1999-07-20 | 2001-01-24 | 张合德 | Process for preparing medicine to cure rheumatoid arthritis |
| CN102274293A (en) * | 2011-08-03 | 2011-12-14 | 赤峰市龙安堂中蒙药研究所 | Muscle and bone relaxing capsules |
| CN104189643A (en) * | 2014-09-09 | 2014-12-10 | 郑州中医骨伤病医院 | Osteopathia rehabilitation pill for treating chronic osteomyelitis |
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2015
- 2015-07-29 CN CN201510452951.7A patent/CN105055742A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1280846A (en) * | 1999-07-20 | 2001-01-24 | 张合德 | Process for preparing medicine to cure rheumatoid arthritis |
| CN102274293A (en) * | 2011-08-03 | 2011-12-14 | 赤峰市龙安堂中蒙药研究所 | Muscle and bone relaxing capsules |
| CN104189643A (en) * | 2014-09-09 | 2014-12-10 | 郑州中医骨伤病医院 | Osteopathia rehabilitation pill for treating chronic osteomyelitis |
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| Title |
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| 候乐荣等: "《郑氏伤科理论与临床》", 28 February 2010, 成都：四川科学技术出版社 * |
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Application publication date: 20151118 |