CN105055498A - Medicine for preventing postoperative respiratory complications caused by endotracheal intubation - Google Patents
Medicine for preventing postoperative respiratory complications caused by endotracheal intubation Download PDFInfo
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Abstract
The invention provides medicine for preventing postoperative respiratory complications caused by endotracheal intubation. The medicine is characterized in that the effective ingredient of the medicine is licorice extracts, and the concentration of the liquorice extracts is 5.96-11.91 mg/mL; preferably, the medicine further comprises auxiliary materials accepted by medical science. It is proved by experiments that liquorice spray can effectively prevent postoperative respiratory complications caused by endotracheal intubation.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine preparation, being specifically related to a kind of for preventing the medicine of the postoperative respiratory tract complication of tracheal intubation.
Background technology
Endotracheal intubation is the most effective method set up at present unobstructed respiratory tract in a short time and effectively breathe, and is general anesthesia, critical, most important link when carrying out cardio-pulmonary resuscitation.But tracheal intubation can cause multiple complications.
Existing clinical conventional lignocaine, lignocaine, as a kind of amide-type local anesthesia, all plays an important role in prevention tracheal intubation Systemic stress response and prevention of postoperative pharyngalgia.But its side effect is more, easily cause neuropathy, cardiovascular system pathological changes and anaphylaxis etc.Therefore, even more ideal, that more effective, side effect medicine that is little and symptomatic treatment has become the postoperative respiratory tract complication for the treatment of tracheal intubation new focus is found.
Summary of the invention
The invention provides a kind of for preventing the medicine of the postoperative respiratory tract complication of tracheal intubation, this medicine can be used in the postoperative respiratory tract complication of prevention tracheal intubation.
The invention provides a kind of for preventing the medicine of the postoperative respiratory tract complication of tracheal intubation, the effective ingredient of described medicine is Radix Glycyrrhizae extract, and in described Radix Glycyrrhizae extract, the concentration of glycyrrhizic acid is 5.96-11.91mg/mL; Preferably, medically acceptable adjuvant is also comprised.
As preferably, alcohol extraction after first for licorice piece water extraction obtains by described Radix Glycyrrhizae extract.
As preferably, the dosage form of described medicine is spray.
The present invention also provides a kind of for preventing the preparation method of the Radix Glycyrrhizae extract of the postoperative respiratory tract complication of tracheal intubation, alcohol extraction after first for licorice piece water extraction is obtained.
As preferably, in described water extraction, amount of water be the 8-15 of licorice piece quality doubly, extraction time is 0.5-1.5 hour, and extraction time is 1-3 time.
As preferably, in described water extraction, amount of water is 8 times of licorice piece quality, and extraction time is 1 hour, and extraction time is 3 times.
As further preferred scheme, in described alcohol extraction, in solution, ethanol contend concentration reaches 45-55%, and the precipitate with ethanol time is 8-15 hour, and alcohol extraction temperature is 30-50 DEG C.
Further preferably, in described alcohol extraction, in solution, ethanol contend concentration reaches 45%, and the precipitate with ethanol time is 12 hours, and alcohol extraction temperature is 40 DEG C.
The present invention also provides the application of said medicine in the medicine of the postoperative respiratory tract complication of preparation prevention tracheal intubation.
As preferably, in licorice piece, the mass concentration of described medicine is 0.2-0.4g/ml.
Of the present invention for preventing the preparation method of the Radix Glycyrrhizae extract of the postoperative respiratory tract complication of tracheal intubation to be:
Extracting liquorice decoction pieces 10g, accurately weighed, add water 80-150mL, decocts and extract 0.5-1.5h, and 1-3 time altogether, filter, filtering residue discards, and filtrate is merged.Filtrate is heated to 30-50 DEG C, and stirring adds ethanol makes volumetric concentration reach 45-55%, and constant temperature precipitate with ethanol 8-15h, gets supernatant after centrifugal, put in Rotary Evaporators and be concentrated into 50mL, sprays bottle fill and get final product.In the Radix Glycyrrhizae extract obtained, the content of glycyrrhizic acid is 5.96-11.91mg/mL.
Application said extracted method, effectively can extract the effective ingredient glycyrrhizic acid in Radix Glycyrrhizae; Glycyrrhizic acid content is higher, uses the effect of the postoperative respiratory tract complication of the Radix Glycyrrhizae extract of same dose prevention tracheal intubation better.
The applicant tests various extracting method, and in the Radix Glycyrrhizae extract that after finding first water extraction, alcohol extraction obtains, the content of glycyrrhizic acid is the highest; The applicant tests water extraction and alcohol extraction condition further, specific as follows:
(1) water extraction: through experiment, the preferred best extraction process by water of orthogonal test is (solid-liquid ratio: 8:1, time: 1h extract: 3 times).
Table 1 water extraction L
9(3
4) orthogonal test factor level table
Table 2 orthogonal design table
Table 3 analysis of variance table
By table 2 and 3 comprehensive analysis, the size that affects of Three factors is: B > C > A, determines that optimum combination is A
1b
2c
3, namely the water backflow 1h of 8 times amount, extracts 3 times.
Because of selected optimised process A
1b
2c
3not data show in orthogonal test, therefore a checking done to orthogonal experiments,
Precision takes licorice piece 10g, and by selected optimum extraction process, measure the content of glycyrrhizic acid, the result is as follows:
Table 4 water extraction partial orthogonality result of the test is verified
(2) precipitate with ethanol: through experiment, the preferred best alcohol precipitation process of orthogonal test is (concentration of alcohol reaches: 45%, the time: 12h, temperature: 40 DEG C);
Table 5 precipitate with ethanol L
9(3
4) orthogonal test factor level table
Table 6 orthogonal design table
Table 7 analysis of variance table
By table 6 and 7 comprehensive analysis, the size that affects of Three factors is: A > C > B, determines that optimum combination is A
1b
2c
2, namely concentration of alcohol reaches: 45%, the time: 12h, temperature: 40 DEG C.
Preparation method of the present invention can retain the principle active component of Radix Glycyrrhizae to greatest extent, and the basis of curative effect ensureing product reduces consumption.Through experimental verification, medicine of the present invention effectively can prevent the postoperative respiratory tract complication of tracheal intubation, and side effect is simultaneously little, not easily causes neuropathy, cardiovascular system pathological changes and anaphylaxis.
Accompanying drawing explanation
Accompanying drawing is used to provide a further understanding of the present invention, and forms a part for description, together with embodiments of the present invention for explaining the present invention, is not construed as limiting the invention.In the accompanying drawings:
Fig. 1 is light Microscopic observation rats breathing road mucosa pathology tectology change (HE dyeing × 10); Wherein A is normal saline group; B is lignocaine group; C is Radix Glycyrrhizae spray low dose group; D is dosage group in Radix Glycyrrhizae spray; E is Radix Glycyrrhizae spray high dose group.
Fig. 2 is each group of cell infiltration degree scoring;
Fig. 3 be Radix Glycyrrhizae extract on the impact of TNF-α content after rat Intubation (n=10,
± s), compare with normal saline group, ▼ P < 0.05;
Fig. 4 be Radix Glycyrrhizae extract on the impact of serum IL-1 content after rat Intubation (n=10,
± s), compare with normal saline group, ▼ P<0.05;
Fig. 5 be Radix Glycyrrhizae extract on the impact of serum IL-10 content after rat Intubation (n=10,
± s), (comparing with normal saline group, ▼ P < 0.05).
Detailed description of the invention
Following embodiment is convenient to understand the present invention better, but does not limit the present invention.Experimental technique in following embodiment, if no special instructions, is conventional method.Test material used in following embodiment, if no special instructions, is and purchases available from routine biochemistry reagent shop.
Licorice piece is purchased from Pharmacy department of Gansu Provincial Hospital of Traditional Chinese Medicine, after testing, meets requirements under Pharmacopoeia of the People's Republic of China standard (version one in 2010) Radix Glycyrrhizae item.
The preparation method of Radix Glycyrrhizae extract of the present invention is:
Extracting liquorice decoction pieces 10g, accurately weighed, add water 80-150mL, decocts and extract 0.5-1.5h, and 1-3 time altogether, filter, filtering residue discards, and filtrate is merged.Filtrate is heated to 30-50 DEG C, and stirring adds ethanol makes volumetric concentration reach 45-55%, and constant temperature precipitate with ethanol 8-15h, gets supernatant after centrifugal, put in Rotary Evaporators and be concentrated into 50mL, sprays bottle fill and get final product.In the Radix Glycyrrhizae extract obtained, the content of glycyrrhizic acid is 5.96-11.91mg/mL.
embodiment 1
The preparation method of the Radix Glycyrrhizae extract of the present embodiment is:
Extracting liquorice decoction pieces 10g, accurately weighed, add water 80mL, decocts and extract 1h, totally 3 times, and filter, filtering residue discards, and filtrate is merged.Filtrate is heated to 40 DEG C, stirring adds ethanol makes volumetric concentration reach 45%, and constant temperature precipitate with ethanol 12h, gets supernatant after centrifugal, put in Rotary Evaporators and be concentrated into 50mL, sprays bottle fill and get final product.In the Radix Glycyrrhizae extract obtained, the content of glycyrrhizic acid is 11.91mg/mL.
embodiment 2
The preparation method of the Radix Glycyrrhizae extract of the present embodiment is:
Extracting liquorice decoction pieces 10g, accurately weighed, add water 80mL, decocts and extract 1.5h, totally 3 times, and filter, filtering residue discards, and filtrate is merged.Filtrate is heated to 40 DEG C, stirring adds ethanol makes volumetric concentration reach 55%, and constant temperature precipitate with ethanol 12h, gets supernatant after centrifugal, put in Rotary Evaporators and be concentrated into 50mL, sprays bottle fill and get final product.
embodiment 3
The preparation method of the Radix Glycyrrhizae extract of the present embodiment is:
Extracting liquorice decoction pieces 10g, accurately weighed, add water 150mL, decocts and extract 1.5h, totally 3 times, and filter, filtering residue discards, and filtrate is merged.Filtrate is heated to 30 DEG C, stirring adds ethanol makes volumetric concentration reach 55%, and constant temperature precipitate with ethanol 15h, gets supernatant after centrifugal, put in Rotary Evaporators and be concentrated into 50mL, sprays bottle fill and get final product.
embodiment 4
The preparation method of the Radix Glycyrrhizae extract of the present embodiment is:
Extracting liquorice decoction pieces 10g, accurately weighed, add water 100mL, decocts and extract 0.5h, totally 3 times, and filter, filtering residue discards, and filtrate is merged.Filtrate is heated to 30 DEG C, stirring adds ethanol makes volumetric concentration reach 50%, and constant temperature precipitate with ethanol 8h, gets supernatant after centrifugal, put in Rotary Evaporators and be concentrated into 50mL, sprays bottle fill and get final product.
embodiment 5
The preparation method of the Radix Glycyrrhizae extract of the present embodiment is:
Extracting liquorice decoction pieces 10g, accurately weighed, add water 100mL, decocts and extract 0.5h, totally 2 times, and filter, filtering residue discards, and filtrate is merged.Filtrate is heated to 40 DEG C, stirring adds ethanol makes volumetric concentration reach 55%, and constant temperature precipitate with ethanol 12h, gets supernatant after centrifugal, put in Rotary Evaporators and be concentrated into 50mL, sprays bottle fill and get final product.
embodiment 6
The preparation method of the Radix Glycyrrhizae extract of the present embodiment is:
Extracting liquorice decoction pieces 10g, accurately weighed, add water 80mL, decocts and extract 1.5h, totally 1 time, and filter, filtering residue discards, and filtrate is merged.Filtrate is heated to 30 DEG C, stirring adds ethanol makes volumetric concentration reach 45%, and constant temperature precipitate with ethanol 12h, gets supernatant after centrifugal, put in Rotary Evaporators and be concentrated into 50mL, sprays bottle fill and get final product.
Above-described embodiment all well can extract the glycyrrhizic acid in Radix Glycyrrhizae, through experiment, all can effectively prevent Intubation respiratory tract complication, wherein, and the Radix Glycyrrhizae extract best results prepared with embodiment 1.The effect of Radix Glycyrrhizae extract (hereinafter referred to as " Radix Glycyrrhizae spray ") to the postoperative respiratory tract complication of prevention tracheal intubation prepared with embodiment 1 is below further detailed.
embodiment 7 Application Example
(1) laboratory animal
SPF level Wistar rat 50, male and female half and half, body weight 200-300g(Mus 7-8 in age week), provided by Gansu Chinese of Traditional Chinese Medicine SPF experimental center.Experiment prospective adaptation is raised one week, and operation consent 12 h fast, freely drinks water.
(2) experiment grouping
Be divided into 5 groups at random by body weight, concrete grammar is as follows:
A group (SPF level Wistar rat quantity n=10) is normal saline group: get 0.9% normal saline 2ml before induction, uses aerosol apparatus to spray into oral cavity, infiltrates uvula and soft palate surrounding tissue;
B group (SPF level Wistar rat quantity n=10) is lignocaine spray group: get 2% lidocaine hydrochloride injection 2mL before induction, uses aerosol apparatus to spray into oral cavity, infiltrates uvula and soft palate surrounding tissue;
C, D, E group (SPF level Wistar rat quantity n=30) is the basic, normal, high dosage group of Radix Glycyrrhizae spray: in licorice piece, and self-control Radix Glycyrrhizae spray mass concentration is: 0.2g/mL.By rat body weight, spray into Radix Glycyrrhizae spray 0.25mL/100g, 0.5mL/100g, 1.0mL/100g respectively before basic, normal, high dosage group induction, infiltrate uvula and soft palate surrounding tissue.
(3) animal model makes
1. pre-treatment is anaesthetized
Laboratory animal is adapted on pretreatment raising one week, preoperative 12 h fast water.
2. induction of anesthesia
Rat sucks 5% ~ 6% isoflurane and maintains anesthesia, and after 30 seconds, visible rat consciousness disappears, and whole-body muscle relaxes.
3. tracheal intubation
Postanesthetic rat is lain on the back and is fixed on operation plate, fixing rat is tilted about 45 degree (rat head-up) together with operating-table, with operating forceps carefully by rat tongue pull-out oral cavity, at this moment Rat Mandibular portion (firmly not excessive, in order to avoid affect rats breathing) is close to a pocket lamp or head lamp.Light-transmissive Rat Mandibular portion's skin of pocket lamp or head lamp and muscle illuminate rat throat, can be clear that the glottis of rat is opened along with breathing and closes as fish mouth, at this moment take advantage of glottis to open moment and rapid tracheal intubation is inserted air flue, then respiratory frequency and the tidal volume of respirator is regulated, i.e. ventilator parameter: frequency 80 times/min, tidal volume 3 ~ 4mL, inspiratory/expiratory is 1:1.5, to maintain the good breathing state of rat.
4. anesthesia maintenance
Continue suction 1.3% isoflurane and maintain anesthesia.
5. recovery from anesthesia
After 60min, off line stops the suction of isoflurane, and extubation after rat is completely clear-headed, is put back to cage, observes to the autonomous diet of energy.
6. histopathologic examination
Treat that rat recovers autonomous diet, put to death immediately, get bottleneck throat and undertissue thereof, drop into 10% formalin solution immediately and fix.Through routine dehydration after drawing materials, after paraffin embedding, section, HE dyeing, do 10 × 10 times of observations under an optical microscope.
7. TNF-α, the mensuration of IL-1 and IL-10 content
Cut-out rat femoral is taken a blood sample, and collect blood by clean tube, room temperature solidifies 2 hours, centrifugal 10 minutes (1500r/min), collects serum encapsulation ,-20 DEG C of freezen protective.TNF-α is detected, IL-1 and IL-10 content by test kit description.
8. statistical analysis
Adopt SPSS17.0 software, enumeration data adopts chi-square criterion, measurement data with means standard deviation (
± s) represent, adopt t inspection, P < 0.05 difference has statistical significance.
(4) result
1. Radix Glycyrrhizae spray is on the impact of respiratory mucosa changes in histopathology after experimental rat tracheal intubation, specifically see Fig. 1.
As Fig. 1 (A), normal saline group upper respiratory tract mucosa pathological change is: mucosal epithelium surface inflammatory is oozed out obviously, the visible a large amount of stove of upper Intradermal or diffuse inflammation cellular infiltration, epithelial cell edema in inflammation stove, part necrocytosis, a large amount of cell infiltration is seen, vasodilation, hyperemia in lamina propria.
As Fig. 1 (B), lignocaine group mucosal epithelium surface inflammatory is oozed out not obvious, and upper Intradermal is dispersed in cell infiltration as seen, epithelial cell Mild edema in inflammation stove, necrocytosis is not obvious, sees a small amount of cell infiltration, blood vessel is obviously expanded, congested in lamina propria.
Radix Glycyrrhizae each dosage group mucosal epithelium surface inflammatory is oozed out all comparatively normal saline group and is alleviated, in lamina propria cell infiltration all comparatively normal saline group alleviate.Low dose group such as Fig. 1 (C) mucosal epithelium surface inflammatory is oozed out, the visible stove of upper Intradermal or diffuse inflammation cellular infiltration, the epithelial cell Mild edema in inflammation stove, a small amount of necrocytosis.Cell infiltration in lamina propria, vasodilation, hyperemia, respiratory mucosa organizes each Rotating fields clear.Middle dosage group such as Fig. 1 (D) mucosal epithelium surface inflammatory is oozed out not obvious, and upper Intradermal is dispersed in cell infiltration as seen, and the epithelial cell Mild edema in inflammation stove, without obvious necrocytosis.Be dispersed in collections cell infiltration in lamina propria, blood vessel is without obviously expansion, hyperemia, and respiratory mucosa organizes each Rotating fields clear.High dose group is as not obvious in Fig. 1 (E) epithelial surface inflammatory exudation, and upper Intradermal is dispersed in cell infiltration as seen, and the epithelial cell Mild edema in inflammation stove, necrocytosis is not obvious.Be dispersed in collections cell infiltration in lamina propria, blood vessel is without obviously expansion, hyperemia, and respiratory mucosa organizes each Rotating fields clear.
Pharyngeal mucosa and undertissue's cell infiltration degree pathological score thereof: NIP cell (0 point); A little inflammatory cell (1 point); The inflammatory cell (2 points) of more skewness; A large amount of inflammatory cell, distribution uniform, rare gathering agglomerating (3 points); A large amount of inflammatory cell assembles agglomerating (4 points).
The comparative result display of each group of rat pharyngeal mucosa and undertissue's cell infiltration degree thereof: each dosage group of Radix Glycyrrhizae spray comparatively normal saline group alleviates and has significant difference (P<0.05).The middle and high dosage group of Radix Glycyrrhizae and lignocaine group difference are without significance (P>0.05).The middle and high dosage group of Radix Glycyrrhizae and low dosage group difference have significance (P<0.05).Specifically see table 8 and Fig. 2.
table 8 respectively group cell infiltration degree scoring (n=10,
±
s)
note: compare ▼ with normal saline group
p< 0.05, compares * with Radix Glycyrrhizae low dose group
p< 0.05
2. Radix Glycyrrhizae spray is on the impact of TNF-α, IL-1 and IL-10 content after rat Intubation
A, Radix Glycyrrhizae spray are on the impact of TNF-α content after rat Intubation
Testing result shows: the content of each dosage group of Radix Glycyrrhizae spray to rat blood serum TNF-α all has reducing effect.Wherein in Radix Glycyrrhizae, dosage group compares normal saline group and has significant difference (P < 0.05).The each dosage group of Radix Glycyrrhizae and lignocaine group difference are without significance (P > 0.05); Specifically see table 9 and Fig. 3.
Table 9 Radix Glycyrrhizae spray on the impact of TNF-α content after rat Intubation (n=10,
±
s)
Note: compare with normal saline group, ▼
p< 0.05*
p< 0.01
B, Radix Glycyrrhizae spray are on the impact of serum IL-1 content after rat Intubation
Testing result shows: the content of each dosage group of Radix Glycyrrhizae spray to rat blood serum IL-1 all has reducing effect.Wherein Radix Glycyrrhizae middle and high dosage group normal saline group compares significant difference (P<0.05 or P < 0.01).The middle and high dosage group of Radix Glycyrrhizae and lignocaine group difference are without significance (P>0.05); Specifically see table 10 and Fig. 4.
Table 10 Radix Glycyrrhizae spray on the impact of serum IL-1 content after rat Intubation (n=10,
± s)
C, Radix Glycyrrhizae spray are on the impact of serum IL-10 content after rat Intubation
Testing result shows: each dosage group of Radix Glycyrrhizae spray all has rising effect to the content of rat blood serum IL-10.Wherein Radix Glycyrrhizae middle and high dosage group normal saline group compares significant difference (P<0.05).The each dosage group of Radix Glycyrrhizae and lignocaine group difference are without significance (P>0.05); Specifically see table 11 and Fig. 5.
Table 11 Radix Glycyrrhizae spray on the impact of serum IL-10 content after rat Intubation (n=10,
±
s)
Note: compare with normal saline group, ▼
p< 0.05
From this experiment, observe Radix Glycyrrhizae spray can obviously alleviate respiratory mucosa cell infiltration, reduce inflammatory exudation, improve cellular edema and vasodilation hyperemia.Show that this medicine can the resistance of enhancing body destructive stimulus to external world, reduce the damage of body.This experimental studies results shows that Radix Glycyrrhizae spray has obvious reducing effect to TNF-α after rat Intubation and IL-1 expression; effect is increased significantly to serum IL-10 content; thus control paathogenic factor link; by cytokine content in regulation and control body; the level of regulation and control pro-inflammatory mediator; effectively can control inflammation, alleviate respiratory tract pathology degree of injury, to respiratory mucosa, there is certain protective role.Observe in experiment, because Radix Glycyrrhizae Aerosol dosage varies in size, than there being different, there is dose-dependant in experimental result, and namely the larger effect of dosage is more remarkable.Radix Glycyrrhizae spray group and Western medicine lignocaine group contrast, without the significance difference opposite sex.
Last it is noted that the foregoing is only the preferred embodiments of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (10)
1. for preventing a medicine for the postoperative respiratory tract complication of tracheal intubation, it is characterized in that: the effective ingredient of described medicine is Radix Glycyrrhizae extract, and in described Radix Glycyrrhizae extract, the concentration of glycyrrhizic acid is 5.96-11.91mg/mL; Preferably, medically acceptable adjuvant is also comprised.
2. medicine according to claim 1, is characterized in that: alcohol extraction after first for licorice piece water extraction obtains by described Radix Glycyrrhizae extract.
3. medicine according to claim 1 and 2, is characterized in that: the dosage form of described medicine is spray.
4. for preventing a preparation method for the Radix Glycyrrhizae extract of the postoperative respiratory tract complication of tracheal intubation, it is characterized in that: alcohol extraction after first for licorice piece water extraction is obtained.
5. preparation method according to claim 4, is characterized in that: in described water extraction, and amount of water is 8-15 times of licorice piece quality, and extraction time is 0.5-1.5 hour, and extraction time is 1-3 time.
6. preparation method according to claim 5, is characterized in that: in described water extraction, and amount of water is 8 times of licorice piece quality, and extraction time is 1 hour, and extraction time is 3 times.
7., according to the arbitrary described preparation method of claim 4-6, it is characterized in that: in described alcohol extraction, in solution, ethanol contend concentration reaches 45-55%, and the precipitate with ethanol time is 8-15 hour, and alcohol extraction temperature is 30-50 DEG C.
8. preparation method according to claim 7, is characterized in that: in described alcohol extraction, and in solution, ethanol contend concentration reaches 45%, and the precipitate with ethanol time is 12 hours, and alcohol extraction temperature is 40 DEG C.
9. the application of the arbitrary described medicine of claim 1-3 in the medicine of the postoperative respiratory tract complication of preparation prevention tracheal intubation.
10. application according to claim 9, is characterized in that: in licorice piece, and the mass concentration of described medicine is 0.2-0.4g/ml.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1965844A (en) * | 2005-11-14 | 2007-05-23 | 北京美倍他药物研究有限公司 | Nasal administered pharmaceutical composition containing glycyrrhetic acid and medical use thereof |
| CN101040935A (en) * | 2006-03-22 | 2007-09-26 | 天津天士力制药股份有限公司 | Dropping pills agent for removing phlegm and relieving asthma and cough and the preparing method |
| CN101669961A (en) * | 2009-09-24 | 2010-03-17 | 无锡正大畜禽有限公司 | Method for producing Chinese-western compound preparation for preventing and treating animal synthetic respiratory diseases |
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2015
- 2015-08-24 CN CN201510521249.1A patent/CN105055498A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1965844A (en) * | 2005-11-14 | 2007-05-23 | 北京美倍他药物研究有限公司 | Nasal administered pharmaceutical composition containing glycyrrhetic acid and medical use thereof |
| CN101040935A (en) * | 2006-03-22 | 2007-09-26 | 天津天士力制药股份有限公司 | Dropping pills agent for removing phlegm and relieving asthma and cough and the preparing method |
| CN101669961A (en) * | 2009-09-24 | 2010-03-17 | 无锡正大畜禽有限公司 | Method for producing Chinese-western compound preparation for preventing and treating animal synthetic respiratory diseases |
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| C06 | Publication | ||
| PB01 | Publication | ||
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| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20151118 |