CN105054906B - A kind of microminiature body temperature and bio-electrical impedance measuring apparatus - Google Patents
A kind of microminiature body temperature and bio-electrical impedance measuring apparatus Download PDFInfo
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- CN105054906B CN105054906B CN201510543195.9A CN201510543195A CN105054906B CN 105054906 B CN105054906 B CN 105054906B CN 201510543195 A CN201510543195 A CN 201510543195A CN 105054906 B CN105054906 B CN 105054906B
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Abstract
The invention discloses a kind of microminiature body temperature and bio-electrical impedance measuring apparatus, including FPC connector J1, FPC connector J2, power supply circuit, four-way bridge-type measurement of bldy temperature circuit, triple channel bio-electrical impedance measuring circuit, test network circuit and function of tonic chord chip operation circuit.Small volume of the present invention, excellent performance, error is no more than ± 0.05 DEG C in terms of the body temperature measurement, error is no more than ± 2 Ω in terms of bio-electrical impedance measuring, this facilitate that needing to measure wearable device and the exploitation of other equipment of body temperature and bio-electrical impedance.
Description
Technical field
The invention belongs to biomedical and wearable device technical field, and in particular to a kind of microminiature body temperature and biological electricity
The design of impedance measurement device.
Background technology
Wearable computer is a kind of new ideas, superminiature, wearable computer system, due to that " can dress " in people
On body, it is possible to realize it is man-machine between natural, convenient and directly interaction, allow one to carry calculating in a more natural way
Equipment and obtain computing function, finally realize it is man-machine between " best combination and collaboration ".Predicted according to authoritative department, wearable section
Skill can be next opera involving much singing and action of in the market, and following 3 or five years market values will develop into about 500 from today 30~5,000,000,000 dollar
Hundred million dollars, market potential is very huge, and (Wei protects the analysis of will hot spot technologies patent prewarning《Wearable computing devices fascicle》[M] north
Capital：Intellectual Property Publishing House, 2014,1).In the market has had the wearable healthy equipment of some great intention and value, example
Such as, Zephyr BioModule body-building clothes.Zephyr BioModule body-building clothes chest locations have a circular biology to pass
There is one can monitor the accelerometer of action and speed in sensor (BioModule), this biological sensor, can measure
(Wei protects the analysis of will hot spot technologies patent prewarning to heart rate, respiratory rate and the skin temperature of user《Wearable computing devices point
Volume》[M] Beijing：Intellectual Property Publishing House, 2014,10-11).This exactly illustrates various physiological signal collection functions to be embedded into
Wearable device field has splendid application prospect.
Body temperature refers to the mean temperature in body deep, there is deep temperature (temperature of splanchnocoel, internal organs and brain) and skin temperature
Point of (shell temperature), it is to reflect one of important indicator of human health status, and its accuracy directly influences examining for disease
Disconnected, treatment and nursing.Due to deep temperature not Easy Test, clinically generally machine is represented with armpit, oral cavity, rectum etc. temperature
Body body temperature.The general measure means of body temperature are mainly：Contact measurement method and contactless measurement.According to this 2 kinds of sides
Method, conventional clinical thermometer is divided into：Mercury thermometer, thermoelectric thermometer, compensation by thermistor and infrared ray radiating bodies in glass
Temperature meter.
Bio-electrical impedance technology refers to the nothing that Human Physiology information is extracted using the electrical characteristic of biological tissue and organ
Create detection technique.It is that faint detection electric current is inputted to the mankind using the electrode for being placed in body surface, then measures suitable position
Voltage change, so that the electrical impedance situation of change of linked groups or organ is obtained, to obtain physiology and pathological information.This technology
Due to there is hurtless measure, it is safety and low cost, easy, be widely applied in medical science, mainly include：Reactance blood flow
(center is helped in the intellectual property right-safeguarding of dlx. Anshans in terms of figure, human body impedance imaging, measuring body composition：Biological electricity and life
Thing electrical impedance technology Patent analyzes [EB/OL] .www.as12330.gov.cn/fwtx/ShowArticle.asp
ArticleID=1250, December 4,2013).Being applied the common equipment developed based on bio-electrical impedance measuring of in the market more
Face, the HBF-214 fatty measuring instruments of such as Omron Corp are deserved to be called in body fat.
However, traditional bio-electrical impedance measuring instrument can not be well embedded in because bulky, power consumption is high
Among wearable device, the wearable device of bio-electrical impedance measuring can be carried out which results in the market is few, and have simultaneously
The equipment for having measurement of bldy temperature and bio-electrical impedance measuring is then more few.
The content of the invention
The invention aims to solve, bio-electrical impedance measuring equipment instrument traditional in the prior art is huge, power consumption
It is high, it is impossible to the problem of being well embedded among wearable device, it is proposed that a kind of microminiature body temperature and bio-electrical impedance measuring
Device.
The technical scheme is that：A kind of microminiature body temperature and bio-electrical impedance measuring apparatus, including FPC connector
J1, FPC connector J2, power supply circuit, four-way bridge-type measurement of bldy temperature circuit, triple channel bio-electrical impedance measuring circuit, test
Lattice network and function of tonic chord chip operation circuit；FPC connector J1, power supply circuit, four-way bridge-type measurement of bldy temperature circuit, three
Passage bio-electrical impedance measuring circuit, test network circuit are connected with function of tonic chord chip operation circuit respectively, FPC connector J1 with
Power supply circuit is connected, and FPC connector J2 is connected with triple channel bio-electrical impedance measuring circuit；
FPC connector J1 is used to external power source access power supply circuit and transmits external data signal；
Power supply circuit is used for outside Power convert into rated voltage；
Test network circuit is used for the pumping signal for receiving to carry out autonomic function chip operation circuit, then output feedback signal
Sampled to function of tonic chord chip operation circuit；
It is connected inside FPC connector J2 with the current channel and voltage channel in triple channel bio-electrical impedance measuring circuit,
For providing the interface being connected with positioned at the electrode slice of human body；
Triple channel bio-electrical impedance measuring circuit is used to receive the pumping signal for carrying out autonomic function chip operation circuit, and leads to
FPC connector J2 feeding human bodies are crossed, the feedback signal from human body are then received, and be passed to function of tonic chord chip operation circuit
Carry out subsequent treatment；
Four-way bridge-type measurement of bldy temperature circuit is used to receive the VLDO pumping signals for carrying out autonomic function chip operation circuit, together
When its internal temperature sensor carry out feeding back signal in function of tonic chord chip operation circuit with exporting one after human contact
Subsequent treatment；
Function of tonic chord chip operation circuit include modulation circuit, demodulator circuit, digital circuit, internal two-stage amplifying circuit and
ADC；Modulation circuit produces pumping signal, and input signal is provided for other circuits；Output signal of the demodulator circuit to other circuits
It is demodulated, the signal after demodulation, which is then delivered to ADC, carries out analog-to-digital conversion；Internal two-stage amplifying circuit amplifies four-way bridge-type
The signal of measurement of bldy temperature circuit output, is then sent to ADC and carries out analog-to-digital conversion；The data that ADC is obtained after sampling pass through numeral
Circuit part is transmitted to FPC connector J1.
Preferably, the function of tonic chord chip of function of tonic chord chip operation circuit uses U1 chips AFE4300.
Preferably, FPC connector J2 is the FPC connector of 20pin 0.5mm pin spacing.
Preferably, FPC connector J1 is 20pin FPC connector.
Preferably, power supply circuit is powered using U2 chips TLV71333 for device.
Preferably, each measurement of bldy temperature Channel front end of four-way bridge-type measurement of bldy temperature circuit has a bridge-type resistance electricity
Road；Each bridge-type resistance circuit includes the resistance and a MF51E type NTC themistor of 31 ‰ precision 51K resistances；Often
Individual bridge-type resistance circuit positive-negative output end is all connected to the RC filter circuits of 1 rank respectively.
Preferably, each bio-electrical impedance measuring passage of triple channel bio-electrical impedance measuring circuit includes 4 road signals
Line and 4 ESD diodes；2 road signal wires are current signal line in 4 road signal wires, and 2 road signal wires are voltage signal line in addition.
The beneficial effects of the invention are as follows：
(1) size of the present invention is small, and size is no more than 25mm × 25mm.
(2) present invention measurement body temperature effect is good, due to there is four-way bridge-type measurement of bldy temperature circuit, it is possible to 4 biographies
Sensor is placed on 4 diverse locations of human body, so as to improve the precision of measurement of bldy temperature, measurement of bldy temperature error is carried out not using the present apparatus
More than ± 0.05 DEG C.
(3) excellent performance of present invention measurement bio-electrical impedance, due to there is triple channel bio-electrical impedance measuring circuit, so
3 different parts of human body can be carried out with the measurement of bio-electrical impedance, so as to obtain more accurate result, entered using the present apparatus
Row bio-electrical impedance measuring error is no more than ± 2 Ω.
(4) simple in construction, convenient use of the invention.
Brief description of the drawings
Fig. 1 is the physical arrangement schematic diagram of measurement apparatus top layer in the embodiment of the present invention.
Fig. 2 is the physical arrangement schematic diagram of measurement apparatus bottom in the embodiment of the present invention.
Fig. 3 is measurement apparatus electrical block diagram in the embodiment of the present invention.
Fig. 4 is FPC connector J2 structural representations in the embodiment of the present invention.
Fig. 5 is FPC connector J1 structural representations in the embodiment of the present invention.
Fig. 6 is power supply circuit in the embodiment of the present invention.
Fig. 7 is four-way bridge-type measurement of bldy temperature circuit diagram in the embodiment of the present invention.
Fig. 8 is MF51E types NTC thermistor resistance-temperature profile in the embodiment of the present invention.
Fig. 9 is bio-electrical impedance illustraton of model in the embodiment of the present invention.
Figure 10 is triple channel bio-electrical impedance measuring circuit diagram in the embodiment of the present invention.
Figure 11 is test network circuit diagram in the embodiment of the present invention.
Figure 12 is function of tonic chord chip operation circuit diagram in the embodiment of the present invention.
Embodiment
Embodiments of the invention are further described below in conjunction with the accompanying drawings.
The invention provides a kind of microminiature body temperature and bio-electrical impedance measuring apparatus, its physical arrangement institute as shown in Figure 1, Figure 2
Show, AFE4300 chips and use MF51E type NTC themistors by compact designed, using TI companies, in guarantee property
Device size is no more than 25mm × 25mm in the case of energy.Wherein, region 1 is FPC connector J2, and region 2 is given birth to for triple channel
Thing impedance bioelectrical measurement circuit, region 3 is test network circuit, and region 4 is main functional chip operating circuit, and region 5 is power supply electricity
Road, region 6 is FPC connector J1, and region 7 is four-way bridge-type measurement of bldy temperature circuit diagram.
As shown in figure 3, a kind of microminiature body temperature and bio-electrical impedance measuring apparatus that the present invention is provided include FPC connector
J1, FPC connector J2, power supply circuit, four-way bridge-type measurement of bldy temperature circuit, triple channel bio-electrical impedance measuring circuit, test
Lattice network and function of tonic chord chip operation circuit；FPC connector J1, power supply circuit, four-way bridge-type measurement of bldy temperature circuit, three
Passage bio-electrical impedance measuring circuit, test network circuit are connected with function of tonic chord chip operation circuit respectively, FPC connector J1 with
Power supply circuit is connected, and FPC connector J2 is connected with triple channel bio-electrical impedance measuring circuit.
Wherein, FPC connector J1 is used to external power source access power supply circuit and transmits external data signal, Yong Huke
To be powered by it to equipment, control device and data transfer.
Power supply circuit is used for outside Power convert into+3.3V voltages, so as to the normal work of function of tonic chord chip operation circuit
Make.
Test network circuit is mainly used to provide parameter to bio-electrical impedance measuring, and it can receive to carry out autonomic function chip work
Make the pumping signal of circuit, then output feedback signal is sampled to function of tonic chord chip operation circuit.
FPC connector J2 is mainly responsible for providing the interface being connected with positioned at the electrode slice of human body, its internal meeting and triple channel
Current channel in bio-electrical impedance measuring circuit is connected with voltage channel.
Triple channel bio-electrical impedance measuring circuit is mainly responsible for carrying out the bio-electrical impedance measuring of human body, and it, which is received, comes autonomous
The pumping signal of functional chip operating circuit, and human body is sent into by FPC connector J2, then receive the feedback letter from human body
Number, and it is passed to function of tonic chord chip operation circuit progress subsequent treatment.
The measurement of four-way bridge-type measurement of bldy temperature circuit chief leading cadre's body body temperature temperature, it, which is received, carrys out autonomic function chip
The VLDO pumping signals of operating circuit, while its internal temperature sensor is fed back signal to exporting one after human contact
Subsequent treatment is carried out in function of tonic chord chip operation circuit.
Function of tonic chord chip operation circuit include modulation circuit, demodulator circuit, digital circuit, internal two-stage amplifying circuit and
ADC；Modulation circuit produces pumping signal, and input signal is provided for other circuits；Output signal of the demodulator circuit to other circuits
It is demodulated, the signal after demodulation, which is then delivered to ADC, carries out analog-to-digital conversion；Internal two-stage amplifying circuit amplifies four-way bridge-type
The signal of measurement of bldy temperature circuit output, is then sent to ADC and carries out analog-to-digital conversion；The 16bit data that ADC is obtained after sampling pass through
Digital circuits section is transmitted to FPC connector J1.
As shown in figure 4, FPC connector J2 is the FPC connector of 20pin 0.5mm pin spacing.User can pass through
The interface is connected the electrode slice positioned at human body with device, so as to carry out the measurement of bio-electrical impedance.Each pin of J2 are defined as：3 pin,
4 pin, 7 pin, 10 pin, 11 pin, 14 pin, 17 pin and 20 pin are GND；1 pin is IOUT5；2 pin are IOUT4；5 pin are IOUT3；6 pin
For IOUT2；8 pin are IOUT1；9 pin are IOUT0；12 pin are IN5；13 pin are IN4；15 pin are IN3；16 pin are IN2；18 pin are
IN1；19 pin are IN0.
Wherein, IOUT5 and IOUT4 is connected by wire with 2 electrode slices positioned at human body, constitutes the 3rd bio-electrical impedance
Current channel in Measurement channel；IN5 and IN4 is connected by wire with 2 electrode slices positioned at human body, constitutes the 3rd biological electricity
Voltage channel in impedance measurement passage.IOUT3 and IOUT2 is connected by wire with positioned at 2 electrode slices of human body, composition the
Current channel in two bio-electrical impedance measuring passages；IN3 and IN2 is connected by wire with 2 electrode slices positioned at human body, structure
Voltage channel into the second bio-electrical impedance measuring passage.IOUT1 and IOUT0 passes through wire and 2 electrodes positioned at human body
Piece is connected, and constitutes the current channel in the first bio-electrical impedance measuring passage；IN1 and IN0 is by wire and positioned at 2 of human body
Electrode slice is connected, and constitutes the voltage channel in the first bio-electrical impedance measuring passage.Remaining pin is connected with shielding line, is signal
Quality provides safeguard.
As shown in figure 5, FPC connector J1 is 20pin FPC connector.User powered by the interface to device,
Communicated with device and measurement apparatus working condition.Each pin of J1 are defined as：20 pin and 19 pin export for VLDO；18 pin, 17
Pin, 16 pin and 15 pin input for VCC_IN；14 pin, 13 pin, 12 pin and 11 pin are power supply；10 pin connect XTAL1 3 pins, are
CLK is exported；9 pin are empty；8 pin connect 51 pins of U1 chips, are AUX2 inputs；7 pin connect 15 pins of U1 chips, are AUX1 defeated
Enter；6 pin connect 53 pins of U1 chips, are RESET inputs；5 pin connect 54 pins of U1 chips, are CS inputs；4 pin connect U1 chips
56 pins, are DOUT outputs；3 pin connect 57 pins of U1 chips, are DIN inputs；2 pin connect 58 pins of U1 chips, are SCLK defeated
Enter；1 pin connects 59 pins of U1 chips, is DRDY outputs.
Wherein, by VCC_IN on J1 input and power supply, user can give device to provide power supply.VLDO outputs can be with
Voltage to external equipment offer+1.7V.CLK output can for detection means work clock frequency.User can pass through
A known external voltage is inputted to AUX1 and AUX2 and then is sampled, for detection means working condition.RESET is inputted
For the reseting signal line of whole device；CS inputs are chip selection signal line in SPI protocol；It is defeated that DOUT is output as data in SPI protocol
Go out signal wire；DIN inputs are data-in signal line in SPI protocol；SCLK inputs are clock cable in SPI protocol；DRDY
It is output as device sampling complement mark signal wire.User can be communicated by these signal wires with device, so as to device
It is controlled, reads data.
As shown in fig. 6, in order to provide high-quality+3.3V operating voltages to device, power supply circuit uses U2 chips
TLV71333 powers for device.1 pin of U2 chips connects VCC_IN inputs, is reached while accessing electric capacity C1 between 1 pin and power supply ground
Filter out the effect of noise in input power；2 pin are with connecing power supply；3 pin connect VCC_IN inputs, reach the effect for enabling U2 chips；4 pin
It is empty；5 pin are that power supply exports AVDD, and electric capacity C2 is accessed between 5 pin and GND and reaches the effect for filtering out noise in out-put supply；Together
When, 5 pin are connected with resistance R52, and the R52 other ends are connected with AVDD, and AVDD is the+3.3V voltage needed for subsequent conditioning circuit, and R52 rises
To the effect of current limliting；Power supply between GND series resistance R51, the resistance played two kinds to provide loop, while reducing ground
The effect of noise.The power supply circuit output voltage that the present apparatus is used is+3.3V, and output current is 150mA, power supply noise peak to the maximum
Peak value is no more than 1mV.
Body temperature refers to the mean temperature in body deep, there is deep temperature (temperature of splanchnocoel, internal organs and brain) and skin temperature
Point of (shell temperature), it is to reflect one of important indicator of human health status, and its accuracy directly influences examining for disease
Disconnected, treatment and nursing.Due to deep temperature not Easy Test, clinically generally machine is represented with armpit, oral cavity, rectum etc. temperature
Body body temperature.The general measure means of body temperature are mainly：Contact measurement method and contactless measurement.According to this 2 kinds of sides
Method, conventional clinical thermometer is by being divided into：Mercury thermometer, thermoelectric thermometer, compensation by thermistor and infrared ray in glass
Clinical thermometer.The present invention is improved in existing technical foundation, has selected MF51E temperature measuring type NTC themistors as biography
Sensor carries out measurement of bldy temperature.The sensor bulk is small, resistance accuracy is high, and highest resolution is up to 0.01 DEG C, simultaneous reactions spirit
It is quick, change in resistance can be completed in 1.5 seconds.Measurement of bldy temperature is carried out using the present apparatus, only needs that temperature data can be completed in 2 seconds
Collection.Error is no more than ± 0.05 DEG C.
As shown in fig. 7, each measurement of bldy temperature Channel front end of four-way bridge-type measurement of bldy temperature circuit has a bridge-type electricity
Resistance circuit, each bridge-type resistance circuit includes the resistance and a MF51E type NTC thermistor of 31 ‰ precision 51K resistances
Device, the resistance in parallel with MF51E type NTC themistors is actual and unwelded.Each bridge-type resistance circuit positive-negative output end
The RC filter circuits of 1 rank are connected to respectively, to filter out the high-frequency noise in output signal.
In the first measurement of bldy temperature passage, resistance R13 and resistance R11 series connection, resistance R31 and MF51E type NTC thermistor
Device SENSOR1 is in parallel and then is connected with resistance R12, then 2 series circuit parallel connections, a termination VLDO, the other end after parallel connection
Meet GND.R13 and R11 tie point is the anode output of bridge circuit, and it is connected serially to GND with resistance R14, electric capacity C15；
Meanwhile, R14 is inputted with C15 tie points for INP1, is connected with 2 pin of U1 chips.R12 and thermistor SENSOR1 tie point
As it, is connected serially to GND by the negative terminal output of bridge circuit with resistance R15, electric capacity C16；Meanwhile, R15 and C16 tie points are
INM1 is inputted, and is connected with 3 pin of U1 chips.In addition, series capacitance C14 between INP1 inputs and INM1 inputs.
In the second measurement of bldy temperature passage, resistance R18 and resistance R16 series connection, resistance R32 and MF51E type NTC thermistor
Device SENSOR2 is in parallel and then is connected with resistance R17, then 2 series circuit parallel connections, a termination VLDO, the other end after parallel connection
Meet GND.R18 and R16 tie point is the anode output of bridge circuit, and it is connected serially to GND with resistance R19, electric capacity C18；
Meanwhile, R19 is inputted with C18 tie points for INP2, is connected with 4 pin of U1 chips.R17 and thermistor SENSOR2 tie point
As it, is connected serially to GND by the negative terminal output of bridge circuit with resistance R20, electric capacity C19；Meanwhile, R20 and C19 tie points are
INM2 is inputted, and is connected with 5 pin of U1 chips.In addition, series capacitance C17 between INP2 inputs and INM2 inputs.
In the 3rd measurement of bldy temperature passage, resistance R23 and resistance R21 series connection, resistance R33 and MF51E type NTC thermistor
Device SENSOR3 is in parallel and then is connected with resistance R22, then 2 series circuit parallel connections, a termination VLDO, the other end after parallel connection
Meet GND.R23 and R21 tie point is the anode output of bridge circuit, and it is connected serially to GND with resistance R24, electric capacity C21；
Meanwhile, R24 is inputted with C21 tie points for INP3, is connected with 10 pin of U1 chips.R22 and thermistor SENSOR3 tie point
As it, is connected serially to GND by the negative terminal output of bridge circuit with resistance R25, electric capacity C22；Meanwhile, R25 and C22 tie points are
INM3 is inputted, and is connected with 11 pin of U1 chips.In addition, series capacitance C20 between INP3 inputs and INM3 inputs.
In the 4th measurement of bldy temperature passage, resistance R28 and resistance R26 series connection, resistance R34 and MF51E type NTC thermistors
Device SENSOR4 is in parallel and then is connected with resistance R27, then 2 series circuit parallel connections, a termination VLDO, the other end after parallel connection
Meet GND.R28 and R26 tie point is the anode output of bridge circuit, and it is connected serially to GND with resistance R29, electric capacity C24；
Meanwhile, R29 is inputted with C24 tie points for INP4, is connected with 12 pin of U1 chips.R27 and thermistor SENSOR4 tie point
As it, is connected serially to GND by the negative terminal output of bridge circuit with resistance R30, electric capacity C25；Meanwhile, R30 and C25 tie points are
INM4 is inputted, and is connected with 13 pin of U1 chips.In addition, series capacitance C23 between INP4 inputs and INM4 inputs.
As shown in figure 8, when the temperature residing for MF51E type thermistors changes, its resistance can also change, from
And cause bridge circuit disequilibrium.Therefore the positive-negative output end of bridge circuit can produce voltage difference, can according to this voltage difference
To extrapolate the resistance of MF51E type thermistors with formula (1)：
Wherein V1For VLDO values, V2For output result magnitude of voltage, R is 31 ‰ accuracy resistance values, RxIt is thermistor in quilt
Resistance under testing temperature.After trying to achieve thermistor resistance, the temperature of thermistor local environment can be extrapolated according to formula (2)
Degree：
Wherein RxFor thermistor resistance, R under dut temperature1For in specified temp T1Lower thermistor resistance, B is temperature-sensitive
Resistance B values, T1For certain specified temp, T2For dut temperature.So far, when MF51E type thermistors are attached to human body or contain mouth
It is that can obtain tested body temperature number according to formula (1) and formula (2) by the magnitude of voltage in measurement of bldy temperature circuit after chamber
According to.
In addition, the RC low-pass filter circuits of 1 rank have been connect respectively after each bridge circuit positive-negative output end, according to 1
Rank RC low-pass filter circuits-three dB bandwidth calculation formula (3) understands that filter circuit used in the present apparatus is about by frequency
159.2Hz, and useful signal is a direct current signal, it is high that the filter circuit that this explanation present apparatus is used can meet reduction completely
The requirement of frequency noise.
Bio-electrical impedance measuring, or abbreviation resistance technique, are electrical characteristics and its change of a kind of utilization biological tissue and organ
Law extracts the detection technique of the biomedical information related to Human Physiology, pathological condition.It is generally by being placed in body
The electrode system of table sends into a small AC measurment curtage to detection object, detects corresponding electrical impedance and its change
Change, then according to different application purposes, obtain related physiology and pathological information.It has noninvasive, harmless, cheap, operation
The features such as simple and function information is abundant, doctor and patient are easy to receive.External Electrical Bioimpedance Measurement Technology is ground on basis
Level is higher in terms of studying carefully, and the bio-impedance technique of new generation by developing direction of electrical impedance tomography technology just attracts various countries
Increasing researcher.Domestic bio-impedance technique is based on application study, using various impedances, admittance rheography as representative
Bio-impedance technique be widely used in clinic, and the clinical practice levels that constantly make progress are higher.The essential structure list of human body
Position is cell.Cell is coated with by the pellicle that one layer has special construction and function, referred to as cell membrane or plasma membrane, and it allows certain
A little materials selectively pass through, while strictly keeping the stabilization of intracellular matter composition.Cell membrane not still cell and surrounding ring
Barrier between border, is also the door that cell receives extraneous or other impact cells.Various physics sexual stimuluses in cellular environment,
The chemical irritation thing such as hormone and mediator for producing in vivo, and some drugses entered in human body etc., much act on first
Cell membrane, then influences intracellular various physiological functions again.Cell film character and its change reflect human body life from cell level
Reason, pathological state and change.Because cell membrane is present, the equivalent circuit that tissue impedance operator can be as shown in Figure 9 is represented.
R0, R1It is respectively resistanceper unit length of external fluid with C, intracellular fluid resistance, cell membrane capacitance, ω is the angular frequency of input test signal, resistance
Anti- Z can be expressed as formula (4)：
As shown in Figure 10, each bio-electrical impedance measuring passage of triple channel bio-electrical impedance measuring circuit includes 4 tunnels
Signal wire and 4 ESD diodes；2 road signal wires are current signal line in 4 road signal wires, and 2 road signal wires are voltage signal in addition
Line.
In the 3rd bio-electrical impedance measuring passage, resistance R39 and electric capacity C26 series connection, the termination U1 chips of series circuit one
22 pin, a termination current signal IOUT5；Resistance R40 and electric capacity C27 series connection, the pin of the termination U1 of series capacitance one chips 23, a termination
Current signal IOUT4；In order to prevent static electricity on human body from damaging equipment, IOUT5 and ESD diode D12 are connected serially to GND, IOUT4 with
ESD diode D11 is connected serially to GND.In addition, voltage signal line IN5 is connected with electric capacity C45, the C45 other ends and the pin phase of U1 chips 33
Even；Voltage signal line IN4 is connected with electric capacity C43, and the C43 other ends are connected with the pin of U1 chips 34；In order to prevent static electricity on human body from damaging
Equipment, IN5 and ESD diode D6 is connected serially to GND, IN4 and ESD diode D5 and is connected serially to GND.
In the second bio-electrical impedance measuring passage, resistance R41 and electric capacity C28 series connection, the termination U1 chips of series circuit one
24 pin, a termination current signal IOUT3；Resistance R42 and electric capacity C29 series connection, the pin of the termination U1 of series circuit one chips 25, a termination
Current signal IOUT2；In order to prevent static electricity on human body from damaging equipment, IOUT3 and ESD diode D10 are connected serially to GND, IOUT2 with
ESD diode D9 is connected serially to GND.In addition, voltage signal line IN3 is connected with electric capacity C42, the C42 other ends and the pin phase of U1 chips 35
Even；Voltage signal line IN2 is connected with electric capacity C44, and the C44 other ends are connected with the pin of U1 chips 36；In order to prevent static electricity on human body from damaging
Equipment, IN3 and ESD diode D4 is connected serially to GND, IN2 and ESD diode D3 and is connected serially to GND.
In the first bio-electrical impedance measuring passage, resistance R43 and electric capacity C30 series connection, the termination U1 chips of series circuit one
26 pin, a termination current signal IOUT1；Resistance R44 and electric capacity C31 series connection, the pin of the termination U1 of series capacitance one chips 27, a termination
Current signal IOUT0；In order to prevent static electricity on human body from damaging equipment, IOUT1 and ESD diode D8 is connected serially to GND, IOUT0 and ESD
Diode D7 is connected serially to GND.In addition, voltage signal line IN1 is connected with electric capacity C41, the C41 other ends are connected with the pin of U1 chips 37；
Voltage signal line IN0 is connected with electric capacity C40, and the C40 other ends are connected with the pin of U1 chips 38；In order to prevent static electricity on human body damages from setting
Standby, IN1 and ESD diode D2 is connected serially to GND, IN0 and ESD diode D1 and is connected serially to GND.
When carrying out bio-electrical impedance measuring, 2 electrode slices are pasted first on the inside of the wrist of human body, then on the inside of ankle
2 electrode slices are pasted, then electrode slice is connected with FPC connector J2 by wire.An electrode slice and pin wherein in wrist
An electrode slice at ankle is connected with 2 signal wires in the current channel of the bio-electrical impedance measuring passage of certain in device respectively,
Remaining 2 electrode slices are connected with 2 signal wires in voltage channel in that passage respectively, for example, IOUT0 signal wires are with being located at
The electrode slice 1 of ankle is connected, and IOUT1 signal wires are connected with the electrode slice 2 positioned at wrist, IN0 signal wires and the electricity positioned at ankle
Pole piece 3 is connected, and IN1 signal wires are connected with the electrode slice 4 positioned at wrist.When the device is operated, U1 chip internals can produce one
Current value maximum is no more than 800 μ A high frequency sinusoidal AC signal, then injects human body by current channel, user can basis
Demand is the arbitrary value in 10HZ-250KHZ the frequency configuration of the signal.After this electric current is injected into human body, because human body
There is bio-electrical impedance in inside, so obvious voltage signal occurs between two other electrode slice, and inside of human body
Bioelectric impedance value is bigger, and voltage signal amplitude is bigger.Because this 2 electrode slices are connected with the voltage channel of device, production
Raw voltage signal can be transferred into device U1 chips and be demodulated, and a d. c. voltage signal can be obtained after demodulation.This
Individual voltage signal values mean that more greatly bioelectric impedance value is bigger.Then it can extrapolate tested personnel's according to formula (5)
Bio-electrical impedance numerical value：
Z=k × V+o (5)
Wherein Z is bioelectric impedance value, and k is the slope value obtained according to test network, and o is obtained according to test network
Deviant.
As shown in figure 11, in test network circuit, electric capacity C36, resistance R49 and electric capacity C37 series connection.Wherein, R49 and
C36 tie points are that RP1 is connected with electric capacity C32, and the C32 other ends are connected with the pin of U1 chips 28；R49 and C37 tie points are RN1 and electricity
Hold C34 to be connected, the C34 other ends are connected with the pin of U1 chips 30；The C36 other ends are VSENP_R1, are connected with the pin of U1 chips 39；C37
The other end is VSENM_R1, is connected with the pin of U1 chips 41.In addition, electric capacity C38, resistance R50 and electric capacity C39 series connection.Wherein, R50
It is that RP0 is connected with electric capacity C33 with C38 tie points, the C33 other ends are connected with the pin of U1 chips 29；R50 and C39 tie points be RN0 with
Electric capacity C35 is connected, and the C35 other ends are connected with the pin of U1 chips 31；The C38 other ends are VSENP_R0, are connected with the pin of U1 chips 40；
The C39 other ends are VSENM_R0, are connected with the pin of U1 chips 42.
Test network circuit is for providing slope k value and offset o values to when calculating bio-electrical impedance.In circuit
R49 resistances are 100 fixed Ω, when giving the sinusoidal current signal of one high frequency of its two ends addition by RP1 and RN1, its meeting
A sinusoidal voltage signal can be produced at VSENP_R1 and VSENM_R1 two ends, U1 chip internals produce this just afterwards
String voltage signal is demodulated to d. c. voltage signal V1.Similarly, R50 resistances are 1000 fixed Ω in circuit, when by RP0 and
When RN0 gives the sinusoidal current signal of one high frequency of its two ends addition, it can produce one at VSENP_R0 and VSENM_R0 two ends
Individual sinusoidal voltage signal, afterwards U1 chip internals this sine voltage signal produced is demodulated to d. c. voltage signal V0。
The V obtained according to known R49, R50 resistance and sampling1、V0Value, you can calculated by formula (6) and obtain slope k value and skew
Measure o values：
As shown in figure 12, the function of tonic chord chip of function of tonic chord chip operation circuit uses U1 chips AFE4300.Crystal oscillator XTAL1
1MHZ work clock is provided for U1 chips AFE4300.XTAL1 1 pin is empty；2 pin meet GND；3 pin export for CLK, with U1 cores
Series resistance R10 between the pin of piece 79, while its series resistance R35 between GND；4 pin are connected with AVDD, while 4 pin and ground
Between 2 electric capacity C12 of series connection and C13, C12 and C13 play a part of filtering out power supply noise.The pin of U1 chips 80 is connected with AVDD, electricity
Hold C6 and C5 in parallel, its one end is connected with the pin of U1 chips 80, and another termination GND, wherein C6 and C5 are played and filtered out power supply noise
Effect.Series resistance R1 between the pin of U1 chips 7 and 8 pin.R1 acquiescence resistances are 130K, can be obtained according to formula (7), U1 chip internals
Amplifying circuit first order multiplication factor is 2.5 times.
Then user can between 1,2,3,4 by software merit rating second level multiplication factor, second level multiplication factor
Choosing.The pin of U1 chips 16 exports for VLDO, and it is connected with resistance R2, electric capacity C8, R2 and another termination GND of C8.The pin of U1 chips 17 is
VREF is exported, and is connected serially to GND with electric capacity C7, C7 plays a part of filtering out noise in reference voltage.The pin of U1 chips 18 meets AVDD.U1
Series resistance R3 and electric capacity C9 between the pin of chip 19 and 20 pin, working environment is provided for U1 chip internals DAC.The pin of U1 chips 22 with
Series resistance R36 between 23 pin, plays a part of protecting pin.Series resistance R37 between the pin of U1 chips 24 and 25 pin, plays guarantor
The effect of pillar pin.Series resistance 38 between the pin of U1 chips 26 and 27 pin, plays a part of protecting pin.The pin of U1 chips 28 and 30
Series resistance R45 protects U1 chip pins between pin, and series resistance R46 protects U1 chip pins between 29 pin and 31 pin.U1 cores
The pin of piece 46 is connected with AVDD, and electric capacity C3 and C4 parallel connection one terminates 46 pin, and another termination GND, C3 and C4, which play to filter out in power supply, to make an uproar
The effect of sound.Series resistance R4, electric capacity C10 and resistance R5 between the pin of U1 chips 47 and 48 pin, are U1 chip internal demodulating equipments
Working environment is provided.Series resistance R6, electric capacity C11 and resistance R7 between the pin of U1 chips 49 and 50 pin, are the demodulation of U1 chip internals
Device provides working environment.Series resistance R8 between the pin of U1 chips 53 and AVDD, series resistance R9 between 59 pin and AVDD, this two
Individual resistance plays a part of pull-up resistor.U1 chips 1,6,9,14,21,32,60 and 76 pin meet GND.U1 chips 43,44,52,
55th, 61,62-75,77 pin are all empty.
One of ordinary skill in the art will be appreciated that embodiment described here is to aid in reader and understands this hair
Bright principle, it should be understood that protection scope of the present invention is not limited to such especially statement and embodiment.This area
Those of ordinary skill can make according to these technical inspirations disclosed by the invention various does not depart from the other each of essence of the invention
Plant specific deformation and combine, these deformations and combination are still within the scope of the present invention.
Claims (7)
1. a kind of microminiature body temperature and bio-electrical impedance measuring apparatus, including：Function of tonic chord chip operation circuit, four-way bridge-type body
Temperature measurement circuit, triple channel bio-electrical impedance measuring circuit and power supply circuit, it is characterised in that also including FPC connector J1,
FPC connector J2 and test network circuit；
The FPC connector J1, power supply circuit, four-way bridge-type measurement of bldy temperature circuit, triple channel bio-electrical impedance measuring circuit,
Test network circuit is connected with function of tonic chord chip operation circuit respectively；The FPC connector J1 is connected with power supply circuit；It is described
FPC connector J2 is connected with triple channel bio-electrical impedance measuring circuit；
The FPC connector J1 is used to external power source access power supply circuit and transmits external data signal；
The power supply circuit is used for outside Power convert into rated voltage；
The test network circuit is used for the pumping signal for receiving to carry out autonomic function chip operation circuit, then output feedback signal
Sampled to function of tonic chord chip operation circuit；
It is connected inside the FPC connector J2 with the current channel and voltage channel in triple channel bio-electrical impedance measuring circuit,
For providing the interface being connected with positioned at the electrode slice of human body；
The triple channel bio-electrical impedance measuring circuit is used to receive the pumping signal for carrying out autonomic function chip operation circuit, and leads to
FPC connector J2 feeding human bodies are crossed, the feedback signal from human body are then received, and be passed to function of tonic chord chip operation circuit
Carry out subsequent treatment；
The four-way bridge-type measurement of bldy temperature circuit is used to receive the VLDO pumping signals for carrying out autonomic function chip operation circuit, together
When its internal temperature sensor carry out feeding back signal in function of tonic chord chip operation circuit with exporting one after human contact
Subsequent treatment；
The function of tonic chord chip operation circuit include modulation circuit, demodulator circuit, digital circuit, internal two-stage amplifying circuit and
ADC；The modulation circuit produces pumping signal, and input signal is provided for other circuits；The demodulator circuit is to other circuits
Output signal is demodulated, and the signal after demodulation, which is then delivered to ADC, carries out analog-to-digital conversion；The internal two-stage amplifying circuit is put
The signal of big four road bridge-type measurement of bldy temperature circuit output, is then sent to ADC and carries out analog-to-digital conversion；After the ADC samplings
To data transmitted by digital circuits section to FPC connector J1.
2. microminiature body temperature according to claim 1 and bio-electrical impedance measuring apparatus, it is characterised in that the function of tonic chord
The function of tonic chord chip of chip operation circuit uses U1 chips AFE4300.
3. microminiature body temperature according to claim 1 and bio-electrical impedance measuring apparatus, it is characterised in that the FPC connects
Connect the FPC connector for the 0.5mm pin spacing that device J2 is 20pin.
4. microminiature body temperature according to claim 1 and bio-electrical impedance measuring apparatus, it is characterised in that the FPC connects
Connect the FPC connector that device J1 is 20pin.
5. microminiature body temperature according to claim 1 and bio-electrical impedance measuring apparatus, it is characterised in that the power supply electricity
Road is powered using U2 chips TLV71333 for device.
6. microminiature body temperature according to claim 1 and bio-electrical impedance measuring apparatus, it is characterised in that the four-way
Each measurement of bldy temperature Channel front end of bridge-type measurement of bldy temperature circuit has a bridge-type resistance circuit；Each bridge-type resistance electricity
Road includes the resistance and a MF51E type NTC themistor of 31 ‰ precision 51K resistances；Each bridge-type resistance electricity
Road positive-negative output end is all connected to the RC filter circuits of 1 rank respectively.
7. microminiature body temperature according to claim 1 and bio-electrical impedance measuring apparatus, it is characterised in that the triple channel
Each bio-electrical impedance measuring passage of bio-electrical impedance measuring circuit includes 4 road signal wires and 4 ESD diodes；Described 4
2 road signal wires are current signal line in the signal wire of road, and 2 road signal wires are voltage signal line in addition.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1312052A (en) * | 2000-01-31 | 2001-09-12 | 株式会社百利达 | Biological impedance apparatus formed by single-sheet integrated circuit |
| CN2654035Y (en) * | 2003-07-03 | 2004-11-10 | 李江 | Universal serial bus interface human body impedance detector |
| CN201043913Y (en) * | 2007-05-23 | 2008-04-02 | 深圳清华力合传感科技有限公司 | Multifunctional human body scale |
| CN203379116U (en) * | 2013-07-19 | 2014-01-08 | 重庆医科大学 | High-precision double-channel bioimpedance measuring instrument |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080091089A1 (en) * | 2006-10-12 | 2008-04-17 | Kenneth Shane Guillory | Single use, self-contained surface physiological monitor |
| WO2009146214A1 (en) * | 2008-04-18 | 2009-12-03 | Corventis, Inc. | Method and apparatus to measure bioelectric impedance of patient tissue |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1312052A (en) * | 2000-01-31 | 2001-09-12 | 株式会社百利达 | Biological impedance apparatus formed by single-sheet integrated circuit |
| CN2654035Y (en) * | 2003-07-03 | 2004-11-10 | 李江 | Universal serial bus interface human body impedance detector |
| CN201043913Y (en) * | 2007-05-23 | 2008-04-02 | 深圳清华力合传感科技有限公司 | Multifunctional human body scale |
| CN203379116U (en) * | 2013-07-19 | 2014-01-08 | 重庆医科大学 | High-precision double-channel bioimpedance measuring instrument |
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