CN105051543A - Acy-1作为缺血再灌注、移植功能延迟和移植活性的生物标记物的用途及其方法 - Google Patents

Acy-1作为缺血再灌注、移植功能延迟和移植活性的生物标记物的用途及其方法 Download PDF

Info

Publication number
CN105051543A
CN105051543A CN201480015268.0A CN201480015268A CN105051543A CN 105051543 A CN105051543 A CN 105051543A CN 201480015268 A CN201480015268 A CN 201480015268A CN 105051543 A CN105051543 A CN 105051543A
Authority
CN
China
Prior art keywords
acy
sample
level
patient
patients
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201480015268.0A
Other languages
English (en)
Chinese (zh)
Inventor
R·E·班克斯
M·P·W·史密斯
P·J·塞尔比
A·莱温顿
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Leeds
Original Assignee
University of Leeds
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Leeds filed Critical University of Leeds
Publication of CN105051543A publication Critical patent/CN105051543A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/978—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • G01N2333/98—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/24—Immunology or allergic disorders
    • G01N2800/245—Transplantation related diseases, e.g. graft versus host disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G01N2800/324—Coronary artery diseases, e.g. angina pectoris, myocardial infarction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/70—Mechanisms involved in disease identification
    • G01N2800/7019—Ischaemia

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN201480015268.0A 2013-03-13 2014-03-13 Acy-1作为缺血再灌注、移植功能延迟和移植活性的生物标记物的用途及其方法 Pending CN105051543A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1304460.7 2013-03-13
GBGB1304460.7A GB201304460D0 (en) 2013-03-13 2013-03-13 Biomarker
PCT/GB2014/050768 WO2014140595A1 (en) 2013-03-13 2014-03-13 Use of acy-1 as a marker of ischaemia/reperfusion, delayed graft function and graft viability as well as method thereof

Publications (1)

Publication Number Publication Date
CN105051543A true CN105051543A (zh) 2015-11-11

Family

ID=48189800

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201480015268.0A Pending CN105051543A (zh) 2013-03-13 2014-03-13 Acy-1作为缺血再灌注、移植功能延迟和移植活性的生物标记物的用途及其方法

Country Status (6)

Country Link
US (1) US10184941B2 (enExample)
EP (1) EP2972384B1 (enExample)
JP (1) JP6285972B2 (enExample)
CN (1) CN105051543A (enExample)
GB (1) GB201304460D0 (enExample)
WO (1) WO2014140595A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111187784A (zh) * 2020-02-12 2020-05-22 青岛农业大学 氨基酰化酶-1的用途
WO2024076485A1 (en) * 2022-10-06 2024-04-11 Natera, Inc. Nucleic acid analysis of perfusion or flush fluids

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3789765A1 (en) * 2019-09-09 2021-03-10 ETH Zürich A method for evaluating damage of solid tissue

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003025571A1 (en) * 2001-09-14 2003-03-27 Alan Kleinfeld Diagnostic markers for ischemia
WO2004074815A2 (en) * 2003-02-14 2004-09-02 Beth Israel Deaconess Medical Center, Inc. Predicting graft rejection
WO2010083121A1 (en) * 2009-01-15 2010-07-22 The Board Of Trustees Of The Leland Stanford Junior University Biomarker panel for diagnosis and prediction of graft rejection
CN102105794A (zh) * 2008-06-04 2011-06-22 B.R.A.H.M.S有限公司 移植物衰竭和死亡的标志物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2892171B2 (ja) * 1991-03-22 1999-05-17 寳酒造株式会社 ポリペプチド
WO2008032868A1 (fr) * 2006-09-15 2008-03-20 Shimadzu Corporation Marqueur tumoral du cancer du rein, et méthode de détermination de la survenue du cancer du rein
FR2933773B1 (fr) * 2008-07-10 2013-02-15 Biomerieux Sa Procede de dosage de la proteine disulfide isomerase pour le diagnostic in vitro du cancer colorectal
ES2356217B1 (es) 2009-08-04 2012-02-13 Universidad De Salamanca Método para la detección de daño renal.

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003025571A1 (en) * 2001-09-14 2003-03-27 Alan Kleinfeld Diagnostic markers for ischemia
WO2004074815A2 (en) * 2003-02-14 2004-09-02 Beth Israel Deaconess Medical Center, Inc. Predicting graft rejection
CN102105794A (zh) * 2008-06-04 2011-06-22 B.R.A.H.M.S有限公司 移植物衰竭和死亡的标志物
WO2010083121A1 (en) * 2009-01-15 2010-07-22 The Board Of Trustees Of The Leland Stanford Junior University Biomarker panel for diagnosis and prediction of graft rejection

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
YORK E. MILLER ET AL.: "Monoclonal Antibody Based Immunoassay for Human Aminoacylase-1", 《JOURNAL OF IMMUNOASSAY》 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111187784A (zh) * 2020-02-12 2020-05-22 青岛农业大学 氨基酰化酶-1的用途
CN111187784B (zh) * 2020-02-12 2022-03-08 青岛农业大学 氨基酰化酶-1的用途
CN115109767A (zh) * 2020-02-12 2022-09-27 青岛农业大学 氨基酰化酶-1的用途
CN115109767B (zh) * 2020-02-12 2023-07-25 青岛农业大学 一种氨基酰化酶-1提高细菌抗聚乙二醇能力的方法和用途
WO2024076485A1 (en) * 2022-10-06 2024-04-11 Natera, Inc. Nucleic acid analysis of perfusion or flush fluids

Also Published As

Publication number Publication date
EP2972384A1 (en) 2016-01-20
JP2016512325A (ja) 2016-04-25
US10184941B2 (en) 2019-01-22
GB201304460D0 (en) 2013-04-24
WO2014140595A1 (en) 2014-09-18
EP2972384B1 (en) 2017-07-26
JP6285972B2 (ja) 2018-02-28
US20160033507A1 (en) 2016-02-04

Similar Documents

Publication Publication Date Title
Parikh et al. Urine NGAL and IL-18 are predictive biomarkers for delayed graft function following kidney transplantation
US9638701B2 (en) Method to determine treatment of acute heart failure
US20150045245A1 (en) Biomarkers and test panels useful in systemic inflammatory conditions
US20160245826A1 (en) Ltbp2 as a biomarker for renal dysfunction
TWI429752B (zh) 不健康細胞之偵測方法及其應用
US20120129187A1 (en) Diagnostical use of peroxiredoxin 4
CN105051543A (zh) Acy-1作为缺血再灌注、移植功能延迟和移植活性的生物标记物的用途及其方法
CA2814026C (en) Moesin fragments associated with aplastic anemia
CA2814029C (en) Moesin fragments associated with immune thrombocytopenia
JP7612666B2 (ja) 小児患者における腎機能を診断若しくはモニタリングする、又は腎機能障害を診断する方法
US20200064344A1 (en) Use of serum 2-cysteine peroxiredoxins (2-cys-prdx) as biomarkers of chronic kidney diseases
CN104330570B (zh) 人热休克蛋白gp96在制备筛查肝病的产品中的应用
JP5721628B2 (ja) 癌診断用マーカーとしてのプロテインキナーゼＣα
RU2832638C2 (ru) Способ диагностики или мониторинга функции почек или диагностики дисфункции почек у пациентов детского возраста
Batko et al. Predicting long-term kidney graft failure using novel multi-omic blood-based biomarkers and artificial intelligence tools
WO2015026893A1 (en) Predictive biomarkers for metabolic syndrome

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20151111