CN105038665A - Ultraviolet curing medical conductive pressure-sensitive adhesive and preparation method thereof - Google Patents
Ultraviolet curing medical conductive pressure-sensitive adhesive and preparation method thereof Download PDFInfo
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- CN105038665A CN105038665A CN201510536796.7A CN201510536796A CN105038665A CN 105038665 A CN105038665 A CN 105038665A CN 201510536796 A CN201510536796 A CN 201510536796A CN 105038665 A CN105038665 A CN 105038665A
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- 239000004820 Pressure-sensitive adhesive Substances 0.000 title claims abstract description 54
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims abstract description 36
- 238000003756 stirring Methods 0.000 claims abstract description 35
- UHESRSKEBRADOO-UHFFFAOYSA-N ethyl carbamate;prop-2-enoic acid Chemical compound OC(=O)C=C.CCOC(N)=O UHESRSKEBRADOO-UHFFFAOYSA-N 0.000 claims abstract description 29
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 28
- 238000002156 mixing Methods 0.000 claims abstract description 25
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 20
- 239000000178 monomer Substances 0.000 claims abstract description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 13
- 239000012153 distilled water Substances 0.000 claims abstract description 13
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 10
- 239000007788 liquid Substances 0.000 claims abstract description 10
- 229960004063 propylene glycol Drugs 0.000 claims abstract description 10
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 claims abstract description 6
- JLFNLZLINWHATN-UHFFFAOYSA-N pentaethylene glycol Chemical compound OCCOCCOCCOCCOCCO JLFNLZLINWHATN-UHFFFAOYSA-N 0.000 claims abstract description 6
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 36
- 229920001451 polypropylene glycol Polymers 0.000 claims description 19
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 claims description 18
- ISAOCJYIOMOJEB-UHFFFAOYSA-N benzoin Chemical group C=1C=CC=CC=1C(O)C(=O)C1=CC=CC=C1 ISAOCJYIOMOJEB-UHFFFAOYSA-N 0.000 claims description 18
- 238000006243 chemical reaction Methods 0.000 claims description 18
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims description 18
- 239000004721 Polyphenylene oxide Substances 0.000 claims description 15
- 229910052797 bismuth Inorganic materials 0.000 claims description 15
- 229920000570 polyether Polymers 0.000 claims description 15
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical group OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 11
- -1 acrylic ester Chemical class 0.000 claims description 11
- 229960000935 dehydrated alcohol Drugs 0.000 claims description 11
- 235000011187 glycerol Nutrition 0.000 claims description 11
- 239000011837 N,N-methylenebisacrylamide Substances 0.000 claims description 10
- ZIUHHBKFKCYYJD-UHFFFAOYSA-N n,n'-methylenebisacrylamide Chemical group C=CC(=O)NCNC(=O)C=C ZIUHHBKFKCYYJD-UHFFFAOYSA-N 0.000 claims description 10
- 244000028419 Styrax benzoin Species 0.000 claims description 9
- 235000000126 Styrax benzoin Nutrition 0.000 claims description 9
- 235000008411 Sumatra benzointree Nutrition 0.000 claims description 9
- 229960002130 benzoin Drugs 0.000 claims description 9
- 239000003153 chemical reaction reagent Substances 0.000 claims description 9
- 235000019382 gum benzoic Nutrition 0.000 claims description 9
- 229920002799 BoPET Polymers 0.000 claims description 8
- 239000003999 initiator Substances 0.000 claims description 7
- OMIGHNLMNHATMP-UHFFFAOYSA-N 2-hydroxyethyl prop-2-enoate Chemical compound OCCOC(=O)C=C OMIGHNLMNHATMP-UHFFFAOYSA-N 0.000 claims description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 6
- VLCAYQIMSMPEBW-UHFFFAOYSA-N methyl 3-hydroxy-2-methylidenebutanoate Chemical group COC(=O)C(=C)C(C)O VLCAYQIMSMPEBW-UHFFFAOYSA-N 0.000 claims description 6
- DVKJHBMWWAPEIU-UHFFFAOYSA-N toluene 2,4-diisocyanate Chemical compound CC1=CC=C(N=C=O)C=C1N=C=O DVKJHBMWWAPEIU-UHFFFAOYSA-N 0.000 claims description 5
- 229920000909 polytetrahydrofuran Polymers 0.000 claims description 4
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 3
- 239000005057 Hexamethylene diisocyanate Substances 0.000 claims description 3
- 239000005058 Isophorone diisocyanate Substances 0.000 claims description 3
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 3
- 150000002148 esters Chemical class 0.000 claims description 3
- RRAMGCGOFNQTLD-UHFFFAOYSA-N hexamethylene diisocyanate Chemical compound O=C=NCCCCCCN=C=O RRAMGCGOFNQTLD-UHFFFAOYSA-N 0.000 claims description 3
- NIMLQBUJDJZYEJ-UHFFFAOYSA-N isophorone diisocyanate Chemical compound CC1(C)CC(N=C=O)CC(C)(CN=C=O)C1 NIMLQBUJDJZYEJ-UHFFFAOYSA-N 0.000 claims description 3
- 239000011780 sodium chloride Substances 0.000 claims description 3
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims description 2
- CQEYYJKEWSMYFG-UHFFFAOYSA-N butyl acrylate Chemical compound CCCCOC(=O)C=C CQEYYJKEWSMYFG-UHFFFAOYSA-N 0.000 claims description 2
- 238000001723 curing Methods 0.000 abstract description 17
- 239000003431 cross linking reagent Substances 0.000 abstract description 4
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 239000000017 hydrogel Substances 0.000 abstract description 2
- 239000003792 electrolyte Substances 0.000 abstract 2
- 230000000977 initiatory effect Effects 0.000 abstract 2
- 239000011248 coating agent Substances 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- 230000002349 favourable effect Effects 0.000 abstract 1
- 230000001678 irradiating effect Effects 0.000 abstract 1
- 230000007794 irritation Effects 0.000 abstract 1
- 239000011259 mixed solution Substances 0.000 abstract 1
- 230000002522 swelling effect Effects 0.000 abstract 1
- 239000002904 solvent Substances 0.000 description 9
- 230000000694 effects Effects 0.000 description 4
- 238000006116 polymerization reaction Methods 0.000 description 4
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 3
- 239000011230 binding agent Substances 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 238000007720 emulsion polymerization reaction Methods 0.000 description 2
- 229920002521 macromolecule Polymers 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000000016 photochemical curing Methods 0.000 description 2
- 239000002253 acid Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 238000009998 heat setting Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 235000019633 pungent taste Nutrition 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000012265 solid product Substances 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
Abstract
The invention relates to an ultraviolet curing medical conductive pressure-sensitive adhesive comprising a functional monomer, a soft monomer, urethane acrylate, a crosslinking agent, electrolyte, NaOH, distilled water, absolute ethyl alcohol, PEG400, glycerol, 1, 2-propylene glycol and an ultraviolet initiating agent. A preparation method of the ultraviolet curing medical conductive pressure-sensitive adhesive comprises the steps of adding the ultraviolet initiating agent, urethane acrylate, the crosslinking agent and absolute ethyl alcohol into a beaker A, and dissolving by stirring; adding the electrolyte, NaOH and distilled water into a beaker B, dissolving by stirring, then, adding the functional monomer, the soft monomer, PEG400, glycerol and 1, 2-propylene glycol into the beaker B, and dissolving by stirring; and mixing the liquids in the two beakers, coating the mixed solution, and irradiating under ultraviolet light. The ultraviolet curing medical conductive pressure-sensitive adhesive has the beneficial effects that conductive pressure-sensitive adhesives with great cohesion and binding power differences can be prepared due to the variation of addition amount of urethane acrylate; and the conductive pressure-sensitive adhesive has no irritation to the skin and is hydrogel with favorable biocompatibility and excellent swelling property.
Description
Technical field
The present invention relates to medical conductive pressure sensitive adhesive of a kind of ultra-violet curing and preparation method thereof.
Background technology
Medical conductive pressure sensitive adhesive is that one both had pressure-sensitive, possesses again the pressure sensitive adhesives of electroconductibility.So-called pressure-sensitive, refers to and does not rely on solvent, solution, just can realize a kind of binding agent bondd only by contact pressure, its main feature is easy to adhere to this pressure sensitive adhesive, can not leave residue simultaneously when stripping.So-called electroconductibility is that this pressure sensitive adhesives can be good at delivered current signal after boning with various medical equipment.
Along with the requirement of environment protection is more and more higher; because solvent type pressure-sensitive adhesive agent also exists some following problems: due to the toxic solvent contained in solvent pressure-sensitive adhesive; and inflammable, very large pollution is produced to environment, thus constrains the widespread use of solvent-borne type pressure sensitive adhesives.
Conventional emulsion polymerization technology there will be emulsion system heat because be difficult to transmit and cause gel cruelly poly-, and the emulsion polymerization technology of preparation adopts emulsifying agent and water as solvent, thus the letex polymerization pressure sensitive adhesive curing cycle prepared obtains prolongation, and it is low that operating efficiency becomes.
Along with the development of uv photopolymerization theory and the requirement of people to environmental protection more and more higher, thus more and more higher for the cry producing green product, photocuring is a kind of novel green technology, refer under the effect of light (Uv and visible light), liquid oligopolymer or monomer are through crosslinking polymerization thus the process of the solid product formed, thus achieve solvent-free discharge, not only safe but also do not pollute the environment, achieve curing speed fast, production efficiency is high, is applicable to the production of streamline.Need within several hours, just can complete for those thermofixations, photocuring only needs just can complete a few second.
Acrylate pressure-sensitive adhesive prepared by most uv photopolymerization technology all not can be good at solving acrylate pressure-sensitive adhesive tack, hold the difficult problem that viscosity, set time and volumetric shrinkage balance altogether, and the acrylate pressure-sensitive adhesive of great majority preparation hard and crisp, thus and be not suitable for industrialization and produce on a large scale hold viscosity extreme difference.
Summary of the invention
The technical problem to be solved in the present invention is: based on the problems referred to above, the invention provides medical conductive pressure sensitive adhesive of a kind of ultra-violet curing and preparation method thereof.
The present invention solves the technical scheme that its technical problem adopts: the medical conductive pressure sensitive adhesive of a kind of ultra-violet curing, by mass percentage, comprise following component: functional monomer 12 ~ 20%, soft monomer 12 ~ 20%, urethane acrylate 1 ~ 8%, linking agent 0.07 ~ 0.3%, ionogen 0.5 ~ 2%, NaOH0.5 ~ 2%, distilled water 12 ~ 15%, dehydrated alcohol 5 ~ 8%, PEG4009 ~ 12%, glycerine 22 ~ 32%, 1, 2-propylene glycol 2 ~ 4% and ultraviolet initiator 0.06 ~ 0.15%, wherein, functional monomer is vinylformic acid, methacrylic acid, one in 2-acrylamide-2-methyl propane sulfonic, soft monomer is β propyloic acrylic ester, 2-EHA, one in butyl acrylate.
The preparation method of the medical conductive pressure sensitive adhesive of ultra-violet curing, comprises the following steps: ultraviolet initiator, urethane acrylate, linking agent and dehydrated alcohol are added in A beaker, stirring and dissolving; Add in B beaker by ionogen, NaOH, distilled water, stirring and dissolving, adds functional monomer, soft monomer, PEG400, glycerine and 1,2-PD in B beaker, stirring and dissolving again; By the liquid mixing in two beakers together, leave standstill 1 ~ 2 hour after stirring, obtain the mixing solutions of clear; Mixing solutions is coated on PET film sheet, irradiates 5 ~ 20 seconds under ultraviolet light, obtain the medical conductive pressure sensitive adhesive of ultra-violet curing.
Further, linking agent is N,N methylene bis acrylamide, and ionogen is KCl, NaCl or NH
4cl, ultraviolet initiator is benzoin dimethylether.
Further, the preparation method of urethane acrylate is: add in reaction vessel by polyether glycol, vulcabond and catalyzer, 60 ~ 80 DEG C are reacted 2 ~ 3 hours, slowly esters of acrylic acid end-capping reagent is instilled again in reaction vessel, 80 ~ 100 DEG C are reacted 10 ~ 12 hours, obtain urethane acrylate.
Further, polyether glycol is the one in polyoxyethylene glycol, polypropylene glycol or polytetrahydrofuran, vulcabond is 2, one in 4-tolylene diisocyanate, isophorone diisocyanate or hexamethylene diisocyanate, end-capping reagent is hydroxyethyl methylacrylate or Hydroxyethyl acrylate, catalyzer is organo-bismuth, the mol ratio of polyether glycol, vulcabond and end-capping reagent is (0.02 ~ 0.05): (0.05 ~ 0.12): (0.06 ~ 0.13), and the content of catalyzer is 0.1 ~ 0.2% of polyether glycol and vulcabond total content.
Further, polyether glycol is polypropylene glycol, and vulcabond is 2,4 toluene diisocyanate.
Urethane acrylate, soft section specifically has the polypropylene glycol, polytetrahydrofuran etc. of different molecular weight, urethane acrylate macromole contains two double bonds due to end, can play the effect of macromolecules cross-linking agent, thus it can play good regulating effect to the force of cohesion of pressure sensitive adhesive and cohesive force; Urethane acrylate and N,N methylene bis acrylamide, under the irradiation of UV-light, increase the intensity of pressure sensitive adhesive; Small molecules ionogen, gives the conductive capability of the pressure sensitive adhesive after ultraviolet light polymerization; NaOH, for the part acid in neutralization solution, improves the pH value of solution, controls 5 ~ 7 by the pH value of the conductive pressure sensitive adhesive after solidification; Distilled water as solvent, for dissolving the compounds such as KCl, NaOH; Dehydrated alcohol is as also having sterilization while solvent, increasing the effect of cohesive force; PEG400 plays the wet performance keeping conductive pressure sensitive adhesive, and plays plasticization effect, and PEG400, glycerine and 1,2-PD are as the sticky humidity and the cohesive force that increase solution while solvent.
The invention has the beneficial effects as follows: some defects solving traditional solvent pressure-sensitive adhesive, letex polymerization type pressure sensitive adhesive, improve working efficiency; Urethane acrylate can prepare force of cohesion and the very large conductive pressure sensitive adhesive of cohesive force difference due to the change of added amount, and the change served only by the percentage composition of macromolecules cross-linking agent just can regulate the viscosity of pressure sensitive adhesive; Conductive pressure sensitive adhesive has no pungency to skin, is that a kind of biocompatibility is good, a kind of hydrogel of swelling behavior excellence, and this medical conductive pressure sensitive adhesive solve before pressure sensitive adhesive there will be the defects such as dry, storage time is short, heat resistance is poor.
Embodiment
The invention will be further described in conjunction with specific embodiments now, and following examples are intended to the present invention instead of limitation of the invention further are described.
Embodiment 1
By 0.02mol polypropylene glycol (Mn=400), 0.05mol2,4-tolylene diisocyanate and organo-bismuth add in reaction vessel, the quality of organo-bismuth is polypropylene glycol and 2,0.1% of 4-tolylene diisocyanate total mass, 60 DEG C are reacted 2 hours, in reaction vessel, slowly instill 0.06mol hydroxyethyl methylacrylate again, 80 DEG C are reacted 10 hours, obtain urethane acrylate.
In mass ratio, 0.08% benzoin dimethylether, 2% urethane acrylate, 0.08%N, N-methylene-bisacrylamide and 7% dehydrated alcohol are added in A beaker, stirring and dissolving; 1.5%KCl, 1.7%NaOH, 12% distilled water are added in B beaker, stirring and dissolving, add the glycerine of 15% vinylformic acid, 15% β propyloic acrylic ester, 12%PEG400,3%1,2-propylene glycol and surplus in B beaker again, stirring and dissolving; By the liquid mixing in two beakers together, leave standstill 1 hour after stirring, obtain the mixing solutions of clear; Mixing solutions is coated on PET film sheet, irradiates 15 seconds under ultraviolet light, obtain the medical conductive pressure sensitive adhesive of ultra-violet curing.
Embodiment 2
By 0.04mol polypropylene glycol (Mn=400), 0.08mol2,4-tolylene diisocyanate and organo-bismuth add in reaction vessel, the quality of organo-bismuth is polypropylene glycol and 2,0.2% of 4-tolylene diisocyanate total mass, 80 DEG C are reacted 3 hours, in reaction vessel, slowly instill 0.1mol hydroxyethyl methylacrylate again, 80 DEG C are reacted 12 hours, obtain urethane acrylate.
In mass ratio, 0.07% benzoin dimethylether, 1% urethane acrylate, 0.09%N, N-methylene-bisacrylamide and 7% dehydrated alcohol are added in A beaker, stirring and dissolving; 2%KCl, 1.5%NaOH, 15% distilled water are added in B beaker, stirring and dissolving, add the glycerine of 16% vinylformic acid, 20% β propyloic acrylic ester, 10%PEG400,4%1,2-propylene glycol and surplus in B beaker again, stirring and dissolving; By the liquid mixing in two beakers together, leave standstill 1 hour after stirring, obtain the mixing solutions of clear; Mixing solutions is coated on PET film sheet, irradiates 10 seconds under ultraviolet light, obtain the medical conductive pressure sensitive adhesive of ultra-violet curing.
Embodiment 3
By 0.02mol polypropylene glycol (Mn=400), 0.05mol2,4-tolylene diisocyanate and organo-bismuth add in reaction vessel, the quality of organo-bismuth is polypropylene glycol and 2,0.1% of 4-tolylene diisocyanate total mass, 60 DEG C are reacted 3 hours, in reaction vessel, slowly instill 0.07mol hydroxyethyl methylacrylate again, 100 DEG C are reacted 10 hours, obtain urethane acrylate.
In mass ratio, 0.08% benzoin dimethylether, 3% urethane acrylate, 0.07%N, N-methylene-bisacrylamide and 8% dehydrated alcohol are added in A beaker, stirring and dissolving; 1.5%KCl, 1.2%NaOH, 12% distilled water are added in B beaker, stirring and dissolving, add the glycerine of 20% vinylformic acid, 14% β propyloic acrylic ester, 12%PEG400,4%1,2-propylene glycol and surplus in B beaker again, stirring and dissolving; By the liquid mixing in two beakers together, leave standstill 1 hour after stirring, obtain the mixing solutions of clear; Mixing solutions is coated on PET film sheet, irradiates 15 seconds under ultraviolet light, obtain the medical conductive pressure sensitive adhesive of ultra-violet curing.
Embodiment 4
By 0.02mol polypropylene glycol (Mn=400), 0.06mol2,4-tolylene diisocyanate and organo-bismuth add in reaction vessel, the quality of organo-bismuth is polypropylene glycol and 2,0.1% of 4-tolylene diisocyanate total mass, 80 DEG C are reacted 2 hours, in reaction vessel, slowly instill 0.09mol Hydroxyethyl acrylate again, 100 DEG C are reacted 10 hours, obtain urethane acrylate.
In mass ratio, 0.09% benzoin dimethylether, 1.2% urethane acrylate, 0.07%N, N-methylene-bisacrylamide and 8% dehydrated alcohol are added in A beaker, stirring and dissolving; 1.5%KCl, 1.5%NaOH, 12% distilled water are added in B beaker, stirring and dissolving, add the glycerine of 18% vinylformic acid, 18% β propyloic acrylic ester, 12%PEG400,4%1,2-propylene glycol and surplus in B beaker again, stirring and dissolving; By the liquid mixing in two beakers together, leave standstill 2 hours after stirring, obtain the mixing solutions of clear; Mixing solutions is coated on PET film sheet, irradiates 20 seconds under ultraviolet light, obtain the medical conductive pressure sensitive adhesive of ultra-violet curing.
Embodiment 5
By 0.02mol polypropylene glycol (Mn=400), 0.05mol2,4-tolylene diisocyanate and organo-bismuth add in reaction vessel, the quality of organo-bismuth is polypropylene glycol and 2,0.1% of 4-tolylene diisocyanate total mass, 80 DEG C are reacted 3 hours, in reaction vessel, slowly instill 0.07mol Hydroxyethyl acrylate again, 80 DEG C are reacted 12 hours, obtain urethane acrylate.
In mass ratio, 0.08% benzoin dimethylether, 4% urethane acrylate, 0.09%N, N-methylene-bisacrylamide and 8% dehydrated alcohol are added in A beaker, stirring and dissolving; 0.5%KCl, 1%NaOH, 13% distilled water are added in B beaker, stirring and dissolving, add the glycerine of 20% vinylformic acid, 16% β propyloic acrylic ester, 10%PEG400,4%1,2-propylene glycol and surplus in B beaker again, stirring and dissolving; By the liquid mixing in two beakers together, leave standstill 2 hours after stirring, obtain the mixing solutions of clear; Mixing solutions is coated on PET film sheet, irradiates 10 seconds under ultraviolet light, obtain the medical conductive pressure sensitive adhesive of ultra-violet curing.
Embodiment 6
By 0.02mol polypropylene glycol (Mn=400), 0.06mol2,4-tolylene diisocyanate and organo-bismuth add in reaction vessel, the quality of organo-bismuth is polypropylene glycol and 2,0.1% of 4-tolylene diisocyanate total mass, 60 DEG C are reacted 3 hours, in reaction vessel, slowly instill 0.06mol Hydroxyethyl acrylate again, 80 DEG C are reacted 12 hours, obtain urethane acrylate.
In mass ratio, 0.07% benzoin dimethylether, 2.4% urethane acrylate, 0.07%N, N-methylene-bisacrylamide and 7% dehydrated alcohol are added in A beaker, stirring and dissolving; 0.9%KCl, 1.3%NaOH, 12% distilled water are added in B beaker, stirring and dissolving, add the glycerine of 16% vinylformic acid, 16% β propyloic acrylic ester, 12%PEG400,4%1,2-propylene glycol and surplus in B beaker again, stirring and dissolving; By the liquid mixing in two beakers together, leave standstill 1 hour after stirring, obtain the mixing solutions of clear; Mixing solutions is coated on PET film sheet, irradiates 15 seconds under ultraviolet light, obtain the medical conductive pressure sensitive adhesive of ultra-violet curing.
Pressure sensitive adhesive binding agent has three relatively important performance index: hold tack, initial bonding strength, stripping strength, and wherein stripping strength is most important, and we mainly measure initial bonding strength and the stripping strength of the conductive pressure sensitive adhesive of embodiment, and concrete data see the following form:
| Maximum peeling force (N) | Average peel force (N) | Falling sphere is tested | Resistance (M Ω) | |
| Embodiment 1 | 4.82 | 3.02 | No. 20 balls | 0.07 |
| Embodiment 2 | 5.04 | 3.12 | No. 22 balls | 0.04 |
| Embodiment 3 | 3.44 | 2.24 | No. 16 balls | 0.07 |
| Embodiment 4 | 4.57 | 2.87 | No. 20 balls | 0.09 |
| Embodiment 5 | 3.36 | 2.01 | No. 16 balls | 0.16 |
| Embodiment 6 | 5.17 | 3.36 | No. 25 balls | 0.10 |
Claims (10)
1. the medical conductive pressure sensitive adhesive of ultra-violet curing, it is characterized in that: by mass percentage, comprise following component: functional monomer 12 ~ 20%, soft monomer 12 ~ 20%, urethane acrylate 1 ~ 8%, linking agent 0.07 ~ 0.3%, ionogen 0.5 ~ 2%, NaOH0.5 ~ 2%, distilled water 12 ~ 15%, dehydrated alcohol 5 ~ 8%, PEG4009 ~ 12%, glycerine 22 ~ 32%, 1, 2-propylene glycol 2 ~ 4% and ultraviolet initiator 0.06 ~ 0.15%, wherein, functional monomer is vinylformic acid, methacrylic acid, one in 2-acrylamide-2-methyl propane sulfonic, soft monomer is β propyloic acrylic ester, 2-EHA, one in butyl acrylate.
2. the medical conductive pressure sensitive adhesive of a kind of ultra-violet curing according to claim 1, it is characterized in that: described linking agent is N,N methylene bis acrylamide, ionogen is KCl, NaCl or NH
4cl, ultraviolet initiator is benzoin dimethylether.
3. the medical conductive pressure sensitive adhesive of a kind of ultra-violet curing according to claim 1, it is characterized in that: the preparation method of described urethane acrylate is: add in reaction vessel by polyether glycol, vulcabond and catalyzer, 60 ~ 80 DEG C are reacted 2 ~ 3 hours, slowly esters of acrylic acid end-capping reagent is instilled again in reaction vessel, 80 ~ 100 DEG C are reacted 10 ~ 12 hours, obtain urethane acrylate.
4. the medical conductive pressure sensitive adhesive of a kind of ultra-violet curing according to claim 3, it is characterized in that: described polyether glycol is polyoxyethylene glycol, one in polypropylene glycol or polytetrahydrofuran, vulcabond is 2, 4-tolylene diisocyanate, one in isophorone diisocyanate or hexamethylene diisocyanate, end-capping reagent is hydroxyethyl methylacrylate or Hydroxyethyl acrylate, catalyzer is organo-bismuth, polyether glycol, the mol ratio of vulcabond and end-capping reagent is (0.02 ~ 0.05): (0.05 ~ 0.12): (0.06 ~ 0.13), the content of catalyzer is 0.1 ~ 0.2% of polyether glycol and vulcabond total content.
5. the medical conductive pressure sensitive adhesive of a kind of ultra-violet curing according to claim 3, it is characterized in that: described polyether glycol is polypropylene glycol, vulcabond is 2,4 toluene diisocyanate.
6. the preparation method of the medical conductive pressure sensitive adhesive of ultra-violet curing according to claim 1, is characterized in that: comprise the following steps: ultraviolet initiator according to claim 1, urethane acrylate, linking agent and dehydrated alcohol are added in A beaker, stirring and dissolving; Add in B beaker by ionogen according to claim 1, NaOH, distilled water, stirring and dissolving, adds functional monomer, soft monomer, PEG400, glycerine and 1,2-PD in B beaker, stirring and dissolving again; By the liquid mixing in two beakers together, leave standstill 1 ~ 2 hour after stirring, obtain the mixing solutions of clear; Mixing solutions is coated on PET film sheet, irradiates 5 ~ 20 seconds under ultraviolet light, obtain the medical conductive pressure sensitive adhesive of ultra-violet curing.
7. the preparation method of the medical conductive pressure sensitive adhesive of ultra-violet curing according to claim 6, is characterized in that: described linking agent is N,N methylene bis acrylamide, and ionogen is KCl, NaCl or NH
4cl, ultraviolet initiator is benzoin dimethylether.
8. the preparation method of the medical conductive pressure sensitive adhesive of ultra-violet curing according to claim 6, it is characterized in that: the preparation method of described urethane acrylate is: add in reaction vessel by polyether glycol, vulcabond and catalyzer, 60 ~ 80 DEG C are reacted 2 ~ 3 hours, slowly esters of acrylic acid end-capping reagent is instilled again in reaction vessel, 80 ~ 100 DEG C are reacted 10 ~ 12 hours, obtain urethane acrylate.
9. the preparation method of the medical conductive pressure sensitive adhesive of ultra-violet curing according to claim 6, it is characterized in that: described polyether glycol is polyoxyethylene glycol, one in polypropylene glycol or polytetrahydrofuran, vulcabond is 2, 4-tolylene diisocyanate, one in isophorone diisocyanate or hexamethylene diisocyanate, end-capping reagent is hydroxyethyl methylacrylate or Hydroxyethyl acrylate, catalyzer is organo-bismuth, polyether glycol, the mol ratio of vulcabond and end-capping reagent is (0.02 ~ 0.05): (0.05 ~ 0.12): (0.06 ~ 0.13), the content of catalyzer is 0.1 ~ 0.2% of polyether glycol and vulcabond total content.
10. the preparation method of the medical conductive pressure sensitive adhesive of ultra-violet curing according to claim 6, is characterized in that: described polyether glycol is polypropylene glycol, and vulcabond is 2,4 toluene diisocyanate.
Priority Applications (1)
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106634791A (en) * | 2016-12-05 | 2017-05-10 | 常州大学 | Preparation method of polyester type conductive pressure-sensitive adhesive |
| CN106635977A (en) * | 2016-12-05 | 2017-05-10 | 常州大学 | Preparation method and application of polymer coating for long-term in-vitro culture of human fat stem cells |
| CN107163866A (en) * | 2017-05-27 | 2017-09-15 | 江苏理工学院 | A kind of medical UV-curable water-borne conductive pressure sensitive adhesive |
| CN109370471A (en) * | 2018-10-26 | 2019-02-22 | 江门市新会区中盛生物科技有限公司 | A kind of medical conducting resinl and preparation method thereof |
| CN109575320A (en) * | 2018-12-04 | 2019-04-05 | 绍兴瑞能新材料科技有限公司 | A kind of conductive hydrogel and its preparation method and application |
| CN111057186A (en) * | 2019-12-04 | 2020-04-24 | 广东省医疗器械研究所 | Photo-curing cross-linking conductive hydrogel and preparation method and application thereof |
| CN114605898A (en) * | 2022-04-08 | 2022-06-10 | 北京工业大学 | Ultraviolet curing coating solution, preparation method, extruded polystyrene board modification method and application |
| CN114835862A (en) * | 2022-07-06 | 2022-08-02 | 中国科学院化学研究所 | Hydrogel type tissue engineering labrum bracket, photocuring 3D printing preparation method thereof and photosensitive resin |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1371685A2 (en) * | 2002-06-14 | 2003-12-17 | Rohm And Haas Company | Aqueous polymeric composition containing polymeric nanoparticles and treatments prepared therefrom |
| CN103450418A (en) * | 2013-09-10 | 2013-12-18 | 合肥乐凯科技产业有限公司 | Acrylic ester-polyurethane emulsion and preparation method thereof |
| CN103031093B (en) * | 2012-12-12 | 2014-12-24 | 常州大学 | Method for preparing water-based urethane acrylate pressure-sensitive adhesive |
| CN104562780A (en) * | 2015-02-09 | 2015-04-29 | 江南大学 | Preparation method of UV photocuring foaming paint for textile |
-
2015
- 2015-08-27 CN CN201510536796.7A patent/CN105038665B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1371685A2 (en) * | 2002-06-14 | 2003-12-17 | Rohm And Haas Company | Aqueous polymeric composition containing polymeric nanoparticles and treatments prepared therefrom |
| CN103031093B (en) * | 2012-12-12 | 2014-12-24 | 常州大学 | Method for preparing water-based urethane acrylate pressure-sensitive adhesive |
| CN103450418A (en) * | 2013-09-10 | 2013-12-18 | 合肥乐凯科技产业有限公司 | Acrylic ester-polyurethane emulsion and preparation method thereof |
| CN104562780A (en) * | 2015-02-09 | 2015-04-29 | 江南大学 | Preparation method of UV photocuring foaming paint for textile |
Non-Patent Citations (1)
| Title |
|---|
| 路剑威等: "丙烯酸酯改性聚酯聚氨酯水分散体的合成及结构表征", 《涂料工业》 * |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106634791A (en) * | 2016-12-05 | 2017-05-10 | 常州大学 | Preparation method of polyester type conductive pressure-sensitive adhesive |
| CN106635977A (en) * | 2016-12-05 | 2017-05-10 | 常州大学 | Preparation method and application of polymer coating for long-term in-vitro culture of human fat stem cells |
| CN106635977B (en) * | 2016-12-05 | 2020-03-20 | 常州大学 | Preparation method and application of polymer coating for human adipose-derived stem cell long-term in-vitro culture |
| CN107163866A (en) * | 2017-05-27 | 2017-09-15 | 江苏理工学院 | A kind of medical UV-curable water-borne conductive pressure sensitive adhesive |
| CN107163866B (en) * | 2017-05-27 | 2020-09-15 | 江苏理工学院 | Medical ultraviolet-curing water-based conductive pressure-sensitive adhesive |
| CN109370471A (en) * | 2018-10-26 | 2019-02-22 | 江门市新会区中盛生物科技有限公司 | A kind of medical conducting resinl and preparation method thereof |
| CN109575320A (en) * | 2018-12-04 | 2019-04-05 | 绍兴瑞能新材料科技有限公司 | A kind of conductive hydrogel and its preparation method and application |
| CN111057186A (en) * | 2019-12-04 | 2020-04-24 | 广东省医疗器械研究所 | Photo-curing cross-linking conductive hydrogel and preparation method and application thereof |
| CN114605898A (en) * | 2022-04-08 | 2022-06-10 | 北京工业大学 | Ultraviolet curing coating solution, preparation method, extruded polystyrene board modification method and application |
| CN114605898B (en) * | 2022-04-08 | 2023-02-10 | 北京工业大学 | Ultraviolet curing coating solution, preparation method, extruded polystyrene board modification method and application |
| CN114835862A (en) * | 2022-07-06 | 2022-08-02 | 中国科学院化学研究所 | Hydrogel type tissue engineering labrum bracket, photocuring 3D printing preparation method thereof and photosensitive resin |
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