CN105030639A - Paste for drawing out toxin and removing acnes, and preparation method of paste - Google Patents

Abstract

The invention discloses paste for drawing out toxin and removing acnes, and a preparation method of the paste. The paste for drawing out toxin and removing acnes is mainly prepared from the following components: cera alba, stearic acid, ozocerite, lanolin, vaseline, squalane, cyclomethicone/PEG-10 polydimethylsiloxane, tocopheryl acetate, isooctyl palmitate, titanium dioxide, toner silicon powder, a psidium guajava leaf extract and hexamidine 2-hydroxyethyl sulphonate. The paste is capable of relieving inflamed acnes within 48 hours, and has relatively good effects of removing acnes and diminishing inflammation. The paste has high effects of diminishing inflammation, sterilizing, resisting oxidation and activating cells, is capable of clearing away heat, detoxifying, and enhancing the immunity, and has a significant curative effect on whelk, acute eczema and vaginal eczema. The paste is a pure oil product, is mild and inirritative, and is capable of blocking invasion of external bacterial again, rapidly permeating the skin bottom, deeply repairing the skin, and removing marks, so that the skin is uniform, fine and smooth.

Description

One is drawn out pus by applying a plaster to the affected part Whelk-eliminating paste and preparation method thereof

[technical field]

The present invention relates to one to draw out pus by applying a plaster to the affected part Whelk-eliminating paste and preparation method thereof, belong to daily cosmetics technical field.

[background technology]

Everyone skin can cause endogenous toxin because of the reason of diet or weather and cause acne or eczema problem, and acne and eczema are when healing, often leave impression at skin surface, because individual physique is different, impression is dark or shallow, retention time or length or short, also it is improper likely to nurse, and causes permanent impression, affects attractive in appearance, concerning the personage that likes to be beautiful, cause not little puzzlement.

Various for product for resolving poxes in the market, print of dispelling weak effect, mostly adopt physics attrition, cost is high, has a big risk, and patient suffering is large, DeGrain, and safety, the still difficult prediction of sequela.As fruit cosmetic improper use, the major injury of skin can be caused.

[summary of the invention]

The object of the invention is to make up the deficiencies in the prior art, provide a kind of and effectively alleviate red and swollen small pox fast, Whelk-eliminating paste of drawing out pus by applying a plaster to the affected part safely and effectively.

Another object of the present invention is to provide a kind of preparation method of above-mentioned Whelk-eliminating paste of drawing out pus by applying a plaster to the affected part.

The present invention to achieve these goals, by the following technical solutions:

One is drawn out pus by applying a plaster to the affected part Whelk-eliminating paste, it is characterized in that being made up of following mass percent component:

A phase:

B phase:

Tocopherol acetas 0.1-1.0%

C phase:

D phase:

Folium Psidii Guajavae extract 0.5-2.0%

Hexamidine dihydroxy ethyl sulfonate 0.05-0.2%

E phase: essence is appropriate.

Hexamidine dihydroxy ethyl sulfonate in the present invention is a kind of water miscible cationic substance with broad-spectrum antiseptic and bactericidal property, has very high sterilization and bacteriostasis property to various gram positive bacteria and negative bacterium and various yeast and mold.

When hexamidine dihydroxy ethyl sulfonate is used in cosmetics and makes antibacterial, its mass fraction is 0.03% ~ 0.1%.In cosmetics, it is not only as antibacterial and antiseptic, can also be used as OTC (over-the-counter).

Research shows, the absorption of skin to hexamidine dihydroxy ethyl sulfonate of the mouse that lives is very poor, and can not be stored in any tissue.Hexamidine dihydroxy ethyl sulfonate is hexamidine by rapid metabolization in mouse body, mainly through urine, is excreted on a small quantity by feces.White mice acute oral 0.71g/kg ~ 2.5g/kg, and big rat is 0.75g/kg.

Under nothing observation effect level conditions, the subchronic oral toxicity of hexamidine dihydroxy ethyl sulfonate is 50mg/kg every day to big rat.

Doing subchronic toxicity test with rabbit, not there is not intoxicating phenomenon to the hexamidine dihydroxy ethyl sulfonate solution of 2% in rabbit.Do transient reaction with the eyes of hexamidine dihydroxy ethyl sulfonate solution to rabbit, 0.05% hexamidine dihydroxy ethyl sulfonate does not produce any reaction, and 0.10% hexamidine dihydroxy ethyl sulfonate produces slight erythema.The rat surface hexamidine dihydroxy ethyl sulfonate solution of 40% being applied to 10% produces slight erythema, Mild edema.

By the research of mouse and rabbit, prove that hexamidine dihydroxy ethyl sulfonate is not a sensitizing agent, the mutation of antibacterial can not be caused.By the test of clinical trial experimenter, 0.10% hexamidine dihydroxy ethyl sulfonate solution can not cause main stimulation and inflammation to people.

Hexamidine dihydroxy ethyl sulfonate is the material with broad-spectrum antiseptic and sterilization flight of steps leading to a palace hall energy, very high sterilization and bacteriostasis property is had to various gram positive bacteria and negative bacterium and various yeast and mold, especially to the pityrosporum ovale causing dandruff, the propionibacterium acnes of acne is caused to have very strong suppression and sterilization effect.Generally speaking, the minimal inhibitory concentration of antibacterial is less, and its sterilizing ability efficiency is higher.

The minimum inhibitory concentration (MIC) of hexamidine dihydroxy ethyl sulfonate to propionibacterium acne is 0.1g/mL, minimum bactericidal concentration (MMC) is 12-4g/mL, relative to the strong manyfold of salicylic acid (MIC>2000/mE) effect; Even than the clindamycin (MIC is about 32g/mL) in antibiotic (cosmetics prohibit the use) and erythromycin (MIC is about 64g/mL) all much effective, it serves to show its killing action powerful to propionibacterium acne.

For opening acne, be used alone antibacterial and just have obvious curative effects, for enclosed type acne, suitably coordinate the raw material adding and peel off infiltration, as (enclose salicylic acid Cyclosystemcomplexsalicylicacid5O%) is more conducive to the rapid performance of bactericidal action.In addition, hexamidine dihydroxy ethyl sulfonate, simultaneously to the inhibitory action of the lipase of propionibacterium acne, makes it be specially adapted to the oily skin of acne tendency.

Folium Psidii Guajavae, containing cupreol, triterpenes, contains Quercetin again.Have antioxidation, antiinflammatory, the physiologically active widely such as antibacterial, Folium Psidii Guajavae extract, by antagonism calcium channel, makes virus can not enter cell because lacking the auxiliary of calcium ion, thus enhancing human body immunity power, reach antiviral object.

Have studied the inhibitory action of Folium Psidii Guajavae extract Flavonoid substances to common causative antibacterial, qualitative experiment and the variable concentrations Folium Psidii Guajavae extract liquid survey minimum inhibitory concentration of inhibition zone is surveyed by filter paper disk test, the antibacterial situation of preliminary understanding Folium Psidii Guajavae extract Quercetin, for seeking it further as " green " antiseptic

Shown by qualitative test result, the various concentration of Folium Psidii Guajavae extracting solution is to obvious for the inhibitory action of bacteria tested as escherichia coli, bacillus subtilis, staphylococcus aureus, Salmonella, shigella.In repressed antibacterial, existing gram positive bacteria, also has gram negative bacteria; Existing coccus, also has bacillus; Bacteriostatic test result shows, Folium Psidii Guajavae extracting solution has obvious inhibitory action to common pathogen and putrefaction bacteria.Wherein the strongest to Salmonella, escherichia coli inhibition.

A preparation method for above-mentioned Whelk-eliminating paste of drawing out pus by applying a plaster to the affected part, is characterized in that comprising the following steps:

A phase is warmed up to 85 DEG C, is incubated 80 DEG C, stirring and dissolving is complete, cooling, add B phase, C phase when being cooled to 75 DEG C, insulation is dissolved completely, stirs, continues to add D phase when being cooled to 50 DEG C, stir, adding E phase when being cooled to 40 DEG C, stirring.

Using method of the present invention is: after clean, get and be applied in relevant portion in right amount, pats to point, and helps product to absorb.

The present invention, relative to prior art, has the following advantages:

The present invention just can allow red and swollen small pox symptom be eased in 48 hours, have good anti-acne, anti-inflammatory effects.The present invention has the powerful effect such as antiinflammatory, sterilization, antioxidation, activating cell, and separate thermal detoxification, reinforced immunological power, being used for the treatment of comedo, acute eczema and vulval eczema has significant curative effect.

The present invention is pure oil product, and can intercept extraneous antibacterial and invade once again, at the bottom of rapid osmotic flesh, gentleness does not stimulate, and deep layer maintenance, dispels impression, makes skin uniform moist.

[detailed description of the invention]

Below in conjunction with specific embodiment, the invention will be further described, refers to table 1:

Table 1: the formula composition of each embodiment, represents with weight percentage.

Table 1:

The preparation technology of above embodiment is as follows:

A phase is warmed up to 85 DEG C, is incubated 80 DEG C, stirring and dissolving is complete, cooling, add B phase, C phase when being cooled to 75 DEG C, insulation is dissolved completely, stirs, continues to add D phase when being cooled to 50 DEG C, stir, adding E phase when being cooled to 40 DEG C, stirring.

The testing performance index result of the embodiment of the present invention is as follows:

1. outward appearance: oiliness mastic

2.pH value:

3. fragrance: conform with the regulations odor type

4. heat-resistant stability investigates (48 DEG C × 24H): qualified

5. cold-resistant study on the stability (-15 DEG C × 24H): qualified

Choosing 200 has the volunteer of small pox to try out the present invention on the face, often organizes 50 people, uses embodiment 1-4 respectively, and every day uses twice sooner or later, and use 15 days continuously, service condition record is as shown in table 2:

Table 2:

Group	Use first day	Use the 3rd day	Use one week	Use two weeks
					Embodiment 1	Redness alleviates	Small pox disappears	Small pox disappears	Small pox disappears
Embodiment 2	Redness alleviates	Small pox disappears	Small pox disappears	Small pox disappears
					Embodiment 3	Small pox disappears	Small pox disappears	Small pox disappears	Small pox disappears
Embodiment 4	Small pox disappears	Small pox disappears	Small pox disappears	Small pox disappears

As shown in Table 2, the present invention is fine to anti-acne effect.

Claims (2)

1. to draw out pus by applying a plaster to the affected part a Whelk-eliminating paste, it is characterized in that being made up of following mass percent component:

A phase:

B phase:

Tocopherol acetas 0.1-1.0%

C phase:

D phase:

Folium Psidii Guajavae extract 0.5-2.0%

Hexamidine dihydroxy ethyl sulfonate 0.05-0.2%

E phase: essence is appropriate.

2. to draw out pus by applying a plaster to the affected part described in claim 1 preparation method of Whelk-eliminating paste, it is characterized in that comprising the following steps:

A phase is warmed up to 85 DEG C, is incubated 80 DEG C, stirring and dissolving is complete, cooling, add B phase, C phase when being cooled to 75 DEG C, insulation is dissolved completely, stirs, continues to add D phase when being cooled to 50 DEG C, stir, adding E phase when being cooled to 40 DEG C, stirring.