CN105012895A - Traditional Chinese medicine composition for treating hemorrhoids and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating hemorrhoids and preparation method thereof Download PDFInfo
- Publication number
- CN105012895A CN105012895A CN201510525201.8A CN201510525201A CN105012895A CN 105012895 A CN105012895 A CN 105012895A CN 201510525201 A CN201510525201 A CN 201510525201A CN 105012895 A CN105012895 A CN 105012895A
- Authority
- CN
- China
- Prior art keywords
- parts
- chinese medicine
- medicine composition
- herba
- hemorrhoid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
- A61K36/195—Strobilanthes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A61K36/315—Isatis, e.g. Dyer's woad
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/538—Schizonepeta
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/758—Zanthoxylum, e.g. pricklyash
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/85—Verbenaceae (Verbena family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a traditional Chinese medicine composition for treating hemorrhoids, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following raw materials: dragon's blood, herba taraxaci, herba lycopi, herba selaginellae, fructus kochiae, flos sophorae, harlequin glorybower leaf and twig, folium mori, pericarpium zanthoxyli, herba schizonepetae, rhizoma curcumae longae, radix isatidis and radix glycyrrhizae. The traditional Chinese medicine composition is reasonable in prescription, has remarkable effects of removing stasis to relieve pain, stopping bleeding and promoting tissue regeneration, reducing swelling and resolving mass, and clearing away heat and toxic materials when used for treating hemorrhoids, has an obvious curative effect, is low in side effect and has a splendid clinical popularization value.
Description
Technical field
The invention belongs to technical field of Chinese medicines, particularly relate to a kind of Chinese medicine composition for the treatment of hemorrhoid and preparation method thereof.
Background technology
Hemorrhoid have another name called blood stasis, hemorrhoid disease, haemorrhoids etc., it is under rectum end mucosa and the vein group of venous plexus expansion formation under anal canal skin, or the swollen thing that the outer phleborrhexis of hemorrhoid or anus edge skin are formed because of inflammation hypertrophy, the difference according to happening part has internal hemorrhoid, external hemorrhoid and mixed hemorrhoid point.Show according to relevant reconnaissance information, the sickness rate of anorectal disease is 59.1%, and the sickness rate of hemorrhoid account for wherein 87.25%, wherein common with internal hemorrhoid again, account for 52.19% of all anal and intestinal diseases.Men and women all can fall ill, and the sickness rate of women is 67%, and the sickness rate of male is 53.9%; Any age all can fall ill, and wherein the people in 20-40 year is comparatively common, and increases the weight of with advancing age and gradually, therefore has saying of " ten people nine hemorrhoid ".The clinical symptoms of hemorrhoid mainly contain have blood in stool, hemorrhoid block is deviate from, pain and pruritus etc.To have blood in stool for a long time known anemia in various degree or even hemorrhagic shock, threat to life; And internal hemorrhoid deviates from anus generation pathological changes when can not send anal back to, being called " incarcerated hemorrhoid ", easily there is severe necrosis and infection in incarcerated hemorrhoid long-term existence, and can be passed through blood system and cause systemic infection, and consequence is serious, therefore, has suffered from hemorrhoid and has treated very important in time.
The etiology and pathogenesis of hemorrhoid is many-sided, the many yang blood and qi prosperity and decline from human body of the traditional Chinese medical science, the etiology and pathogenesis of hemorrhoid is removed to inquire in the aspect such as to influence each other along the cause of disease inside and outside inverse alternation sum of zang-fu differentiation, as " danxi's experiential therapy " is pointed out: " hemorrhoid person is all because of internal organs deficiency in origin; wound rheumatism; interior intrinsic heat poison, liquor-saturated drink handing-over, many for suicide; thus QI and blood tenesmus; the poly-anus of knot, dyspepsia does not fall apart, and conflict is hemorrhoid person "." Plain Questions vital QI of the body connecting with natural QI opinion " cloud: " be thus satiated with food, flaccidity of muscles and vessels, intestinal Bleach is hemorrhoid ".The traditional Chinese medical science thinks that hemorrhoid are that in body, regulative mechanism is not normal, the defect in anatomical physiology and eating and drinking without temperance, constipation, chronic diarrhea chronic dysentery, gestation and menoxenia, sexual strain and a series of pathological changes born that essence is not penetrated, produce under the external motivation effect such as disorder of emotion and heredity.
Western medical treatment hemorrhoid mainly contain operative therapy, ultralow temperature, superhigh temperature therapy, knot cover, loop ligature therapy and injection treatment.Operative therapy can eliminate focus and symptom fast, but often has complication to occur, postoperative easy recurrence; Ultralow temperature, superhigh temperature therapy result are similar to operative therapy, and after treatment, relapse rate is high; Knot cover, loop ligature therapy can make to make podex blood circulation be obstructed, and easily produce congestion edema, pain, difficult defecation etc.; Injection treatment method is easy, more conventional clinically, but injection site and dosage are difficult to control, and dose controls improper meeting and causes downright bad massive hemorrhage, tissue necrosis or infection etc., and consequence is serious.
Chinese traditional treatment hemorrhoid emphasize the principle of dialectical treatmert, can be divided into outer usage and internal treatment to the treatment of hemorrhoid.Ancient times advocate heat-clearing and toxic substances removing to Zhiduo County in hemorrhoid, cooling blood and dissolving stasis, and carry out treating with card according to different syndrome differentiating.The external treatment of Chinese traditional treatment hemorrhoid mainly contains fumigation-washing therapy, drug of topical application therapy and turunda therapy.Chinese traditional treatment hemorrhoid have evident in efficacy, treating both the principal and secondary aspects of a disease, and the obvious advantage of the low grade of drug side effect, clinical development has a extensive future.
Chinese patent application 201410807583.9 discloses a kind of for preventing hemorrhoid to show effect and treating the Chinese medicine composition of hemorrhoid, and its crude drug comprises Rhizoma Coptidis, Myrrha, Poria, Fructus Aurantii Immaturus, Pericarpium Zanthoxyli, Galla Chinensis, the Fructus Kochiae, Folium et Fructus Helwingiae, Crop Gallus domesticus cotyledon, Herba Stellariae Alsines, Herba Rabdosiae glaucocalycis, Herba Ephedrae, Radix Et Caulis Acanthopanacis Senticosi, Herba Asteris Ageratoidis, Radix Sanguisorbae, Indigo Naturalis, Herba Eleusines Indicae and Folium Symplocoris Caudatae.These traditional Chinese medicine composition for treating hemorrhoid have rapid-action, the advantage that drug side effect is low, but need fumigation and washing agent and ZHICHUANG GAO simultaneously with the use of, use very inconvenient.
The oral medicine of current hemorrhoid, medicine for external use and paste medicine expectant treatment and can improve symptom, but it is slow to there is onset, focus eliminate thoroughly do not wait not enough.Seek a kind of rapid-action, Be very effective, efficacy stability, treating both the principal and secondary aspects of a disease and Therapeutic Method treat the active drug of hemorrhoid easily, are current urgent needss clinically.
Summary of the invention
In order to make up the deficiencies in the prior art, alleviate the misery of hemorrhoid patients, first object of the present invention is to provide a kind of Chinese medicine composition for the treatment of hemorrhoid, this Chinese medicine composition has removing blood stasis and relieving pain, hemostasia and promoting granulation, effect of dispersing swelling and dissipating binds and heat-clearing and toxic substances removing, possess rapid-action, therapeutic effect significantly, efficacy stability, treating both the principal and secondary aspects of a disease, applied widely and be easy to advantages such as applying.
Chinese medicine composition of the present invention is prepared from by the raw material of following parts by weight:
Sanguis Draxonis 18-24 part, Herba Taraxaci 20-27 part, Herba Lycopi 14-20 part, Herba Selaginellae 12-17 part, Fructus Kochiae 15-23 part, Flos Sophorae 14-22 part, Folium et Ramulus Clerodendri Trichotomi 7-13 part, Folium Mori 10-16 part, Pericarpium Zanthoxyli 9-17 part, Herba Schizonepetae 8-15 part, Rhizoma Curcumae Longae 5-11 part, Radix Isatidis 11-16 part and Radix Glycyrrhizae 6-13 part.
Preferably, described Chinese medicine composition is prepared from by the raw material of following parts by weight: Sanguis Draxonis 18 parts, Herba Taraxaci 20 parts, Herba Lycopi 14 parts, Herba Selaginellae 12 parts, the Fructus Kochiae 15 parts, 14 parts, Flos Sophorae, Folium et Ramulus Clerodendri Trichotomi 7 parts, 10 parts, Folium Mori, 9 parts, Pericarpium Zanthoxyli, Herba Schizonepetae 8 parts, 5 parts, Rhizoma Curcumae Longae, Radix Isatidis 11 parts and 6 parts, Radix Glycyrrhizae.
Preferably, described Chinese medicine composition is prepared from by the raw material of following parts by weight: Sanguis Draxonis 24 parts, Herba Taraxaci 27 parts, Herba Lycopi 20 parts, Herba Selaginellae 17 parts, the Fructus Kochiae 23 parts, 22 parts, Flos Sophorae, Folium et Ramulus Clerodendri Trichotomi 13 parts, 16 parts, Folium Mori, 17 parts, Pericarpium Zanthoxyli, Herba Schizonepetae 15 parts, 11 parts, Rhizoma Curcumae Longae, Radix Isatidis 16 parts and 13 parts, Radix Glycyrrhizae.
Preferably, described Chinese medicine composition is prepared from by the raw material of following parts by weight: Sanguis Draxonis 21 parts, Herba Taraxaci 25 parts, Herba Lycopi 17 parts, Herba Selaginellae 15 parts, the Fructus Kochiae 18 parts, 17 parts, Flos Sophorae, Folium et Ramulus Clerodendri Trichotomi 11 parts, 14 parts, Folium Mori, 15 parts, Pericarpium Zanthoxyli, Herba Schizonepetae 13 parts, 9 parts, Rhizoma Curcumae Longae, Radix Isatidis 14 parts and 9 parts, Radix Glycyrrhizae.
The prescription analysis of medicament composing prescription of the present invention:
Medicament composing prescription of the present invention with Resina Draconis and Herba Taraxaci for monarch drug, removing blood stasis and relieving pain, hemostasia and promoting granulation, heat-clearing and toxic substances removing, dispersing swelling and dissipating binds; With Herba Lycopi, Herba Selaginellae, the Fructus Kochiae and Flos Sophorae for ministerial drug, blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, clearing away heat and cooling blood, dispelling wind for relieving itching; With Folium et Ramulus Clerodendri Trichotomi, Folium Mori, Pericarpium Zanthoxyli, Herba Schizonepetae, Rhizoma Curcumae Longae and Radix Isatidis for adjuvant drug, heat-clearing and toxic substances removing, warming middle-JIAO to relieve pain, rash of inducing sweat, removing blood stasis circulation of qi promoting; With Radix Glycyrrhizae for making medicine, relieving spasm to stop pain, heat-clearing and toxic substances removing, coordinating the actions of various ingredients in a prescription, all medicines are arranged in pairs or groups, and synergism, reaches detumescence and promoting granulation jointly, and dissipating blood stasis stops blooding, and effect of promoting blood circulation and cooling blood and heat-clearing and toxic substances removing, has very significant therapeutic effect to hemorrhoid.
Second object of the present invention is to provide corresponding manufacturing process and is made and facilitate easy-to-use finished product preparation under the prerequisite ensureing curative effect by this Chinese medicine.
The preparation method of described Chinese medicine composition mainly comprises the following steps:
(1) Herba Taraxaci, Herba Lycopi, the Fructus Kochiae, Folium et Ramulus Clerodendri Trichotomi, Folium Mori, Rhizoma Curcumae Longae, Radix Isatidis and Radix Glycyrrhizae is got, doubly decoct with water 2-3 time by the 4-9 of medical material gross weight, each 2-5h, filter, merging filtrate, being evaporated to relative density under 60-65 DEG C of environment is the extractum of 1.20-1.25, drying under reduced pressure, cross 80-100 mesh sieve after pulverizing, obtain extractum fine powder;
(2) get Resina Draconis, Herba Selaginellae, Flos Sophorae, Pericarpium Zanthoxyli and Herba Schizonepetae, be broken into coarse powder, cross 80-100 mesh sieve, mix with extractum fine powder, stir, obtain this Chinese medicine composition.
Utilize modern general Chinese medicine preparation technology, Chinese medicine composition of the present invention can be made into the finished product preparation of clinical needs, as dosage forms such as gel, ointment, suppository or ointments.
The present invention also discloses a kind of purposes of above-mentioned Chinese medicine composition, and namely above-mentioned Chinese medicine composition is preparing the purposes in medicine for treaching hemorrhoie.Rat Oleum Tiglii hemorrhoid model test shows, and Chinese medicine composition of the present invention is used for the treatment of the effect that hemorrhoid tool is significantly improved rectum vein permeability; Clinical trial also shows, drug regimen of the present invention is used for the treatment of hemorrhoid total effective rate and reaches 96%, and therapeutic effect is significantly higher than positive control drug MAYINGLONG MUSK HEMORRHOID UNGUENTUM, traditional Chinese medicine composition for treating Be very effective of the present invention, can be used as medicine for treaching hemorrhoie to use, clinical generalization value is high.
Compared with prior art, Chinese medicine composition of the present invention has following technical advantage:
(1) compared with the Therapeutic Method of current hemorrhoid, Chinese medicine composition of the present invention is natural pure Chinese medicinal preparation, and untoward reaction and side effect significantly reduce, and Chinese medicine composition effect of the present invention is comprehensive, and medication effect is better, and improves the quality of life of patient.
(2) pharmacological evaluation display, Chinese medicine composition of the present invention as treatment hemorrhoid drug use time, drug effect can obtain the effect significantly improving rectum vein permeability comprehensively, and have rapid-action, good effect etc. treat advantage significantly.
(3) Chinese medicine composition preparation of the present invention is simple, and raw material is easy to get, and also has efficacy stability simultaneously, rapid-action, toxic and side effects is low and be easy to advantages such as applying.
Detailed description of the invention
Below will the present invention is described further by specific embodiment, it will be understood by those skilled in the art that the present invention also can make other similar changes and obtains similar result and do not depart from content of the present invention and scope except following examples.
embodiment 1 prepares the suppository of Chinese medicine composition
Embodiment 1 Chinese medicine composition is prepared from by the raw material of following parts by weight:
Sanguis Draxonis 18 parts, Herba Taraxaci 20 parts, Herba Lycopi 14 parts, Herba Selaginellae 12 parts, the Fructus Kochiae 15 parts, 14 parts, Flos Sophorae, Folium et Ramulus Clerodendri Trichotomi 7 parts, 10 parts, Folium Mori, 9 parts, Pericarpium Zanthoxyli, Herba Schizonepetae 8 parts, 5 parts, Rhizoma Curcumae Longae, Radix Isatidis 11 parts and 6 parts, Radix Glycyrrhizae.
Preparation method is as follows:
(1) Herba Taraxaci, Herba Lycopi, the Fructus Kochiae, Folium et Ramulus Clerodendri Trichotomi, Folium Mori, Rhizoma Curcumae Longae, Radix Isatidis and Radix Glycyrrhizae is got, 2 times are decocted with water by 5 times of medical material gross weight, each 2h, filter, merging filtrate, being evaporated to relative density under 65 DEG C of environment is the extractum of 1.25, drying under reduced pressure, cross 100 mesh sieves after pulverizing, obtain extractum fine powder;
(2) get Resina Draconis, Herba Selaginellae, Flos Sophorae, Pericarpium Zanthoxyli and Herba Schizonepetae, be broken into coarse powder, cross 100 mesh sieves, mix with extractum fine powder, stir, obtain this Chinese medicine composition powder;
(3) get semi-synthetic fatty glyceride and be placed in vessel, heating in water bath melts, and treats that temperature is down to about 50 DEG C, adds above-mentioned Chinese medicine composition powder, stir, rear injection scribbles the bolt mould of lubricant to slightly overflowing die orifice for degree, cooling, spilling of pruning after solidifying part, the demoulding, quality inspection, packaging, to obtain final product.
embodiment 2 prepares the suppository of Chinese medicine composition
Embodiment 2 Chinese medicine composition is prepared from by the raw material of following parts by weight:
Sanguis Draxonis 24 parts, Herba Taraxaci 27 parts, Herba Lycopi 20 parts, Herba Selaginellae 17 parts, the Fructus Kochiae 23 parts, 22 parts, Flos Sophorae, Folium et Ramulus Clerodendri Trichotomi 13 parts, 16 parts, Folium Mori, 17 parts, Pericarpium Zanthoxyli, Herba Schizonepetae 15 parts, 11 parts, Rhizoma Curcumae Longae, Radix Isatidis 16 parts and 13 parts, Radix Glycyrrhizae.
Preparation method is with embodiment 1.
embodiment 3 prepares the ointment of Chinese medicine composition
Embodiment 3 Chinese medicine composition is prepared from by the raw material of following parts by weight:
Sanguis Draxonis 21 parts, Herba Taraxaci 25 parts, Herba Lycopi 17 parts, Herba Selaginellae 15 parts, the Fructus Kochiae 18 parts, 17 parts, Flos Sophorae, Folium et Ramulus Clerodendri Trichotomi 11 parts, 14 parts, Folium Mori, 15 parts, Pericarpium Zanthoxyli, Herba Schizonepetae 13 parts, 9 parts, Rhizoma Curcumae Longae, Radix Isatidis 14 parts and 9 parts, Radix Glycyrrhizae.
Preparation method is as follows:
(1) Herba Taraxaci, Herba Lycopi, the Fructus Kochiae, Folium et Ramulus Clerodendri Trichotomi, Folium Mori, Rhizoma Curcumae Longae, Radix Isatidis and Radix Glycyrrhizae is got, 2 times are decocted with water by 7 times of medical material gross weight, each 2.5h, filter, merging filtrate, being evaporated to relative density under 65 DEG C of environment is the extractum of 1.25, drying under reduced pressure, cross 100 mesh sieves after pulverizing, obtain extractum fine powder;
(2) get Resina Draconis, Herba Selaginellae, Flos Sophorae, Pericarpium Zanthoxyli and Herba Schizonepetae, be broken into coarse powder, cross 100 mesh sieves, mix with extractum fine powder, stir, obtain this Chinese medicine composition powder;
(3) get sodium carboxymethyl cellulose and be placed in mortar, add glycerol and grind well, then grind while add the alcoholic solution of ethyl hydroxybenzoate, grind well after swelling, the gradation of above-mentioned Chinese medicine composition powder is added, grinds well, obtain the ointment of Chinese medicine composition of the present invention.
embodiment 4 prepares the ointment of Chinese medicine composition
Embodiment 4 Chinese medicine composition is prepared from by the raw material of following parts by weight:
Sanguis Draxonis 20 parts, Herba Taraxaci 25 parts, Herba Lycopi 16 parts, Herba Selaginellae 15 parts, the Fructus Kochiae 21 parts, 18 parts, Flos Sophorae, Folium et Ramulus Clerodendri Trichotomi 10 parts, 14 parts, Folium Mori, 14 parts, Pericarpium Zanthoxyli, Herba Schizonepetae 12 parts, 7 parts, Rhizoma Curcumae Longae, Radix Isatidis 12 parts and 11 parts, Radix Glycyrrhizae.
Preparation method is with embodiment 3.
chinese medicine composition pharmacodynamic study of the present invention:
test one: Chinese medicine composition of the present invention is to the test of rat Oleum Tiglii hemorrhoid model
1, experimental animal: the SD rat at regular grade 6-8 monthly age 90, body weight 170-330g, male and female half and half, are divided into 9 groups at random, often organize 10.
2, trial drug and dosage regimen:
A group: trial drug is the Chinese medicine composition powder of the present invention that the embodiment of the present invention 1 obtains, and is deployed into water the suspension that concentration is 0.6g/ml, 0.4g/ml and 0.2g/ml, for subsequent use.Get 3 groups of rats, be labeled as A group high dose group (2.4g/kg), middle dosage group (1.6g/kg) and low dose group (0.8g/kg), high dose group concentration is the drug suspension of 0.6g/ml, middle dosage group concentration is the drug suspension of 0.4g/ml, high dose group concentration is the drug suspension of 0.2g/ml, first 2 days of modeling according to dosage every day drop rectum with drug 2 times, medicine is stained with 10mg cotton balls, cotton balls is filled in internal rectum, during administration next time, first should check whether internal rectum has cotton balls (should take out if any cotton balls), last administration should after modeling 2 hours.
B group: trial drug is the Chinese medicine composition powder of the present invention that the embodiment of the present invention 2 obtains, and dosage regimen is with A group.
Model control group: get 1 group of rat, modeling first 2 days isometric(al) normal saline drop rectum with drug every day 2 times, last administration should after modeling 2 hours.
Positive controls: positive control drug is diyu huaijiao pills (the accurate word Z11020100 of traditional Chinese medicines, Tongrentang Pharmaceutical Factory, Beijing TongrenTang Co., Ltd), the suspension of 0.6g/ml is deployed into water, get 1 group of rat, modeling is front presses dosage drop rectum with drug every day 2 times of 2.4g/kg for 2 days, and last administration should after modeling 2 hours.
Normal group: isometric(al) normal saline drop rectum with drug every day 2 times, successive administration 2 days.
3, set up rat Oleum Tiglii hemorrhoid model: Oleum Tiglii is a kind of conventional proinflammatory agent, by distilled water, pyridine, ether and 6% Oleum Tiglii mix in the ratio of 1:4:5:10, composition Oleum Tiglii mixed liquor.2h before last administration, goes model control group and drug study group rat, and cotton balls leaching being inhaled 0.16mL Oleum Tiglii mixed liquor inserts rat anus, takes out, set up rat Oleum Tiglii hemorrhoid model after stopping 10s.
4, index determining: after modeling 6h, every rat presses the blue normal saline solution of she Wen of dose intravenous injection 1% of 20mg/kg, sacrificed by exsanguination rat after 30min, cut-off intestinal and perianal tissue, 48h is soaked with acetone normal saline by the ratio solution of 7:3 after weighing, centrifugal, get supernatant and measure it in the absorbance at 590nm place, as evaluation vascular permeability index.
5, result of the test: as shown in table 1.
The comparison of rat absorbance respectively organized by table 1
Note: compare with Normal group, model control group
△ p< 0.05,
△ △p < 0.01; Compare with model control group, drug test group
* p< 0.05,
* p< 0.01; Compare with positive controls, Chinese medicine composition drug test group of the present invention
# p< 0.05,
## p< 0.01.
6, conclusion (of pressure testing)
Inflammatory reaction can cause vascular permeability to improve, and this test reflects the therapeutic effect of medicine to rat Oleum Tiglii hemorrhoid model by the evaluation of rectum vein permeability.Test data shows, Chinese medicine composition of the present invention can reduce the rectum vein permeability of Oleum Tiglii hemorrhoid rat model well, in compositions, various Chinese medicinal components synergism in treatment rat Oleum Tiglii hemorrhoid model is strong, Chinese medicine composition A group of the present invention (Chinese medicine composition of the present invention that namely embodiment of the present invention 1 is obtained) middle and high dosage group and Chinese medicine composition B group of the present invention (Chinese medicine composition of the present invention that namely embodiment of the present invention 2 is obtained) high dose group effect are better than positive controls, and all the other respectively organize therapeutic effect and positive controls is suitable.
test two: the clinical trial of Chinese medicine composition of the present invention
(1) study subject is selected
1, tcm diagnosis standard
The content of " diagnosis basis of hemorrhoid " of reference " Chinese medical disease Standardization of diagnosis and curative effect " (2012 editions) and " new Chinese medicine guideline of clinical investigations " is drafted.Diagnostic criteria is:
(1) have blood in stool, deviate from outside anus with swollen thing, the initial stage after an action of the bowels can self-resetting, and the later stage needs manual reduction, anoscopy: mucosal protrusion above tooth trace, or visible surface has fibrosis phenomenon;
(2) having blood in stool less or nothing, incarceration occurring, with having an intense pain;
(3) the livid purple color lump of the subcutaneous burst of anus edge, local skin edema, lump from the beginning of still soft, sharp ache, gradual change is hard, movable, touches a tender spot obviously;
(4) squat during defecation or for a long time, anus edge skin has soft livid purple color agglomerate protuberance (varicosis group), with falling inflation sense, can be able to disappear after agglomerate pressing;
(4) to have blood in stool and podex swells thing, rectal tenesmus, foreign body sensation or pain can be had, can with merocrine secretion's thing or pruritus, in anal canal there is swollen thing (also can be superfluous skin under tooth trace) in the upper and lower same orientation of tooth trace.
Conformance with standard (1) and (2) person can make internal hemorrhoid diagnosis; Meet (3) and (4) person and can make thrombosed external hemorrhoid or the diagnosis of varicose external hemorrhoid; Meet (6) person and can make mixed hemorrhoid diagnosis.
Meet above arbitrary diagnostic criteria and informed consent, be ready that experimenter all can include test case in.4, get rid of and reject case standard
1) inflammatory external hemorrhoid and connective tissue external hemorrhoid (sentinel pile) be not at the row of test;
2) hemorrhoid merge perianal abscess, anal fistula, rectal polyp, rectum carcinoma or intestinal infection disease patient;
3) age is at under-18s or over-65s, trimester of pregnancy or women breast-feeding their children, or those who are allergic to this drug;
4) the severe primary diseases such as cardiovascular and cerebrovascular vessel, Liver and kidney and hemopoietic system are associated with, psychotic;
5) do not meet inclusive criteria, not by regulation medication, cannot judge that curative effect or data do not affect the treatment or safety judgement person entirely.
(2) clinical trial protocol
1, physical data
Go out by diagnosis standard screening the clinical volunteers patient that 200 examples meet hemorrhoid diagnostic criteria, be divided into treatment group and matched group two groups by random, double blinding, principle that is parallel, contrast, often organize each 100 examples, age 20-58 year, 37 years old mean age.Two groups of patients are the influence factor such as sex, age, sick kind, state of an illness distribution, and through statistical procedures, there was no significant difference, meets a point set condition.
2, trial drug and test method
Treatment group: trial drug be the embodiment of the present invention 3 prepare Chinese medicine composition ointment of the present invention, defecation before medication, clean water affected part, external application or anus of receiving, one time 2 grams, 1 time on the one, within 7 days, be a course for the treatment of, after 2 courses for the treatment of, evaluate curative effect.
Matched group: control drug is MAYINGLONG MUSK HEMORRHOID UNGUENTUM (traditional Chinese medicines accurate word Z42021920, Ma Yinglong Pharmaceutical Group Co., Ltd), the same treatment group of medication.
3, curative effect determinate standard
Recovery from illness: after an action of the bowels without hemorrhage, without prolapsus, anoscopy hemorrhoid mucosa recovers normal, blood stasis atresia;
Effective: after an action of the bowels without hemorrhage, without deviating from, blood stasis redness obviously disappears, anoscopy hemorrhoid mucosa mild hyperaemia;
Effective: to still have hemorrhage on a small quantity after an action of the bowels, accompany slight hemorrhoid to deviate from, anoscopy hemorrhoid mucosa mild hyperaemia;
Invalid: symptom and sign without improvement, even increase the weight of.
4, therapeutic outcome, as shown in table 2
Table 2 therapeutic effect
5, conclusion (of pressure testing)
This clinical trial adopts the medicine MAYINGLONG MUSK HEMORRHOID UNGUENTUM for the treatment of hemorrhoid conventional on the market at present as a control group, by comparing with the therapeutic effect of Chinese medicine composition of the present invention, highlights the curative effect of Chinese medicine composition of the present invention.Clinical testing data shows, and Chinese medicine composition of the present invention is for hemorrhoid treating Be very effective, and cure rate reaches 64%, and cure-remarkable-effectiveness rate is more than 80%.The total effective rate of pharmaceutical composition of the present invention is 96%, and the total effective rate being significantly higher than contrast medicine is 76%, proves traditional Chinese medicine composition for treating Be very effective of the present invention, and can be used as medicine for treaching hemorrhoie and use, clinical generalization value is high.
Claims (6)
1. treat the Chinese medicine composition of hemorrhoid for one kind, it is characterized in that, described Chinese medicine composition is prepared from by the raw material of following parts by weight: Sanguis Draxonis 18-24 part, Herba Taraxaci 20-27 part, Herba Lycopi 14-20 part, Herba Selaginellae 12-17 part, Fructus Kochiae 15-23 part, Flos Sophorae 14-22 part, Folium et Ramulus Clerodendri Trichotomi 7-13 part, Folium Mori 10-16 part, Pericarpium Zanthoxyli 9-17 part, Herba Schizonepetae 8-15 part, Rhizoma Curcumae Longae 5-11 part, Radix Isatidis 11-16 part and Radix Glycyrrhizae 6-13 part.
2. the Chinese medicine composition for the treatment of hemorrhoid as claimed in claim 1, it is characterized in that, described Chinese medicine composition is prepared from by the raw material of following parts by weight: Sanguis Draxonis 18 parts, Herba Taraxaci 20 parts, Herba Lycopi 14 parts, Herba Selaginellae 12 parts, the Fructus Kochiae 15 parts, 14 parts, Flos Sophorae, Folium et Ramulus Clerodendri Trichotomi 7 parts, 10 parts, Folium Mori, 9 parts, Pericarpium Zanthoxyli, Herba Schizonepetae 8 parts, 5 parts, Rhizoma Curcumae Longae, Radix Isatidis 11 parts and 6 parts, Radix Glycyrrhizae.
3. the Chinese medicine composition for the treatment of hemorrhoid as claimed in claim 1, it is characterized in that, described Chinese medicine composition is prepared from by the raw material of following parts by weight: Sanguis Draxonis 24 parts, Herba Taraxaci 27 parts, Herba Lycopi 20 parts, Herba Selaginellae 17 parts, the Fructus Kochiae 23 parts, 22 parts, Flos Sophorae, Folium et Ramulus Clerodendri Trichotomi 13 parts, 16 parts, Folium Mori, 17 parts, Pericarpium Zanthoxyli, Herba Schizonepetae 15 parts, 11 parts, Rhizoma Curcumae Longae, Radix Isatidis 16 parts and 13 parts, Radix Glycyrrhizae.
4. the Chinese medicine composition for the treatment of hemorrhoid as claimed in claim 1, it is characterized in that, described Chinese medicine composition is prepared from by the raw material of following parts by weight: Sanguis Draxonis 21 parts, Herba Taraxaci 25 parts, Herba Lycopi 17 parts, Herba Selaginellae 15 parts, the Fructus Kochiae 18 parts, 17 parts, Flos Sophorae, Folium et Ramulus Clerodendri Trichotomi 11 parts, 14 parts, Folium Mori, 15 parts, Pericarpium Zanthoxyli, Herba Schizonepetae 13 parts, 9 parts, Rhizoma Curcumae Longae, Radix Isatidis 14 parts and 9 parts, Radix Glycyrrhizae.
5. the Chinese medicine composition of the treatment hemorrhoid as described in any one of claim 1-4, is characterized in that: described Chinese medicine composition is made into gel, ointment, suppository or ointment.
6. prepare a method for the Chinese medicine composition for the treatment of hemorrhoid as claimed in claim 1, it is characterized in that, the preparation method of described Chinese medicine composition comprises the following steps:
(1) Herba Taraxaci, Herba Lycopi, the Fructus Kochiae, Folium et Ramulus Clerodendri Trichotomi, Folium Mori, Rhizoma Curcumae Longae, Radix Isatidis and Radix Glycyrrhizae is got, doubly decoct with water 2-3 time by the 4-9 of medical material gross weight, each 2-5h, filter, merging filtrate, being evaporated to relative density under 60-65 DEG C of environment is the extractum of 1.20-1.25, drying under reduced pressure, cross 80-100 mesh sieve after pulverizing, obtain extractum fine powder;
(2) get Resina Draconis, Herba Selaginellae, Flos Sophorae, Pericarpium Zanthoxyli and Herba Schizonepetae, be broken into coarse powder, cross 80-100 mesh sieve, mix with extractum fine powder, stir, obtain this Chinese medicine composition.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610327530.6A CN105797085A (en) | 2015-08-25 | 2015-08-25 | Application of traditional Chinese medicine composition to preparation of medicine for treating haemorrhoids |
| CN201510525201.8A CN105012895A (en) | 2015-08-25 | 2015-08-25 | Traditional Chinese medicine composition for treating hemorrhoids and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510525201.8A CN105012895A (en) | 2015-08-25 | 2015-08-25 | Traditional Chinese medicine composition for treating hemorrhoids and preparation method thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610327530.6A Division CN105797085A (en) | 2015-08-25 | 2015-08-25 | Application of traditional Chinese medicine composition to preparation of medicine for treating haemorrhoids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105012895A true CN105012895A (en) | 2015-11-04 |
Family
ID=54403433
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510525201.8A Withdrawn CN105012895A (en) | 2015-08-25 | 2015-08-25 | Traditional Chinese medicine composition for treating hemorrhoids and preparation method thereof |
| CN201610327530.6A Withdrawn CN105797085A (en) | 2015-08-25 | 2015-08-25 | Application of traditional Chinese medicine composition to preparation of medicine for treating haemorrhoids |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610327530.6A Withdrawn CN105797085A (en) | 2015-08-25 | 2015-08-25 | Application of traditional Chinese medicine composition to preparation of medicine for treating haemorrhoids |
Country Status (1)
| Country | Link |
|---|---|
| CN (2) | CN105012895A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105343578A (en) * | 2015-12-12 | 2016-02-24 | 杨献美 | Medicine composition for treating haemorrhoids |
| CN106362044A (en) * | 2016-09-29 | 2017-02-01 | 武汉安孕堂生物科技有限公司 | Chinese medicine gel used for treating hemorrhoids of pregnant women |
| CN106983847A (en) * | 2017-04-26 | 2017-07-28 | 王保国 | A kind of Chinese medicine preparation and its preparation and application for treating hemorrhoid |
| CN115461050A (en) * | 2020-09-11 | 2022-12-09 | 李宗谚 | Pharmaceutical composition and use thereof for treating sarcopenia |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103735998A (en) * | 2014-01-24 | 2014-04-23 | 邹洪胜 | Traditional Chinese medicinal composition for treating haemorrhoids |
| CN104474189A (en) * | 2014-12-05 | 2015-04-01 | 广东聚智诚科技有限公司 | Pharmaceutical composition for treating haemorrhoids |
-
2015
- 2015-08-25 CN CN201510525201.8A patent/CN105012895A/en not_active Withdrawn
- 2015-08-25 CN CN201610327530.6A patent/CN105797085A/en not_active Withdrawn
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103735998A (en) * | 2014-01-24 | 2014-04-23 | 邹洪胜 | Traditional Chinese medicinal composition for treating haemorrhoids |
| CN104474189A (en) * | 2014-12-05 | 2015-04-01 | 广东聚智诚科技有限公司 | Pharmaceutical composition for treating haemorrhoids |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105343578A (en) * | 2015-12-12 | 2016-02-24 | 杨献美 | Medicine composition for treating haemorrhoids |
| CN106362044A (en) * | 2016-09-29 | 2017-02-01 | 武汉安孕堂生物科技有限公司 | Chinese medicine gel used for treating hemorrhoids of pregnant women |
| CN106983847A (en) * | 2017-04-26 | 2017-07-28 | 王保国 | A kind of Chinese medicine preparation and its preparation and application for treating hemorrhoid |
| CN115461050A (en) * | 2020-09-11 | 2022-12-09 | 李宗谚 | Pharmaceutical composition and use thereof for treating sarcopenia |
| CN115461050B (en) * | 2020-09-11 | 2023-11-28 | 李宗谚 | Pharmaceutical composition and use thereof for treating sarcopenia |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105797085A (en) | 2016-07-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104983896A (en) | Traditional Chinese medicine composite for treating haemorrhoids and application thereof | |
| CN105012895A (en) | Traditional Chinese medicine composition for treating hemorrhoids and preparation method thereof | |
| CN105878927A (en) | Method for preparing medical composition capable of treating haemorrhoid | |
| CN103977362A (en) | Traditional Chinese medicine composition for treating hyperplasia of mammary glands and early-stage breast cancer | |
| CN104524071A (en) | Pharmaceutical composition for treating primary renal disease and application thereof | |
| CN104491156B (en) | A kind ofly treat Chinese medicine composition of hemorrhagic hemorrhoid and preparation method thereof | |
| CN105797046A (en) | Traditional Chinese medicine composition for uterine fibroid treatment and postoperative nursing | |
| CN104524477A (en) | Traditional Chinese medicine composition for treating nodular goiter | |
| CN105232845A (en) | Chinese medicine composition for treating hemorrhoid and preparation method thereof | |
| CN105250921A (en) | Traditional Chinese medicine composition for treatment of haemorrhoids | |
| CN108938833B (en) | Traditional Chinese medicine for treating benign prostatic hyperplasia and bladder detrusor dysfunction | |
| CN106214828A (en) | A kind of Chinese medicine of passage, nourishing blood and preparation method thereof | |
| CN105343578A (en) | Medicine composition for treating haemorrhoids | |
| CN105770691A (en) | Medicinal preparation for treating cervical cancer and application thereof | |
| CN105412385A (en) | Pharmaceutical composition for treating hemorrhoids | |
| CN109223951B (en) | Traditional Chinese medicine for treating yin deficiency and fire excess syndrome of purpuric nephritis in children | |
| CN104306948A (en) | Medicament composition for treating gouty arthritis | |
| CN105343762A (en) | Traditional Chinese medicine composition for treating hemorrhoids and preparation method thereof | |
| CN105770271A (en) | Traditional Chinese medicinal composition for treating hemorrhoids and preparation method of traditional Chinese medicinal composition | |
| CN105833209A (en) | Traditional Chinese medicine composition for treating endometriosis uterina | |
| CN1290541C (en) | Medicinal extract for tonifying kidney and enriching blood made from foetal fuzz, and its prepn. method | |
| CN107349300B (en) | Traditional Chinese medicine composition for treating lochiorrhea and application thereof | |
| CN105434808A (en) | Traditional Chinese medicine composition for treating hemorrhoids and preparation method thereof | |
| CN106266970B (en) | A kind of Chinese medicine composition treated production and cause endometritis | |
| CN105412392A (en) | Traditional Chinese medicinal composition for treating hemorrhoids and preparation method of traditional Chinese medicinal composition |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20151104 |
|
| WW01 | Invention patent application withdrawn after publication |