CN105011925B - The making mould and its method of work of a kind of multichannel array microelectrode - Google Patents
The making mould and its method of work of a kind of multichannel array microelectrode Download PDFInfo
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- CN105011925B CN105011925B CN201510452157.2A CN201510452157A CN105011925B CN 105011925 B CN105011925 B CN 105011925B CN 201510452157 A CN201510452157 A CN 201510452157A CN 105011925 B CN105011925 B CN 105011925B
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- plate
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- flat board
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Abstract
The invention discloses a kind of making mould of multichannel array microelectrode and its method of work, the mould includes：Flat board, which is provided with flat board opening；Device of the flat board opening edge provided with fixed row's female connectors；Flat board both sides are respectively fixed with the first location-plate and the second location-plate through flat board, and the top of the first location-plate and the second location-plate is connected with the first pillar, and the bottom of the first location-plate and the second location-plate is connected with the second pillar；It is additionally provided with and is parallel to each other and vertical with flat board the 3rd location-plate and the 4th location-plate in flat board opening；First pillar passes through the 3rd location-plate and the 4th location-plate, and the second pillar passes through the 3rd location-plate and the 4th location-plate；Some groups of chromatogram post holes arranged in arrays are additionally provided with 3rd location-plate and the 4th location-plate, chromatographic column passes through chromatogram post holes, forms chromatographic column array.
Description
Technical field
The invention belongs to a kind of making mould applications of microelectrode, more particularly to a kind of making of multichannel array microelectrode
Mould and its method of work.
Background technology
With the development of Electrophysiology technology, the recording electrode of neuron electric signal from traditional glass microelectrode gradually
Develop into current multi-channel metal microelectrode.Such multi-channel electrode can recorded multiple neurons in specific site simultaneously
Unicellular action potential and field potential, provide a kind of ideal means for the detection of Electrophysiology, its develop and
Using the working mechanism for furtheing investigate cerebral neuron, the mechanism of neutral net Information Conduction, processing and storage, production are disclosed
Huge impetus has been given birth to simultaneously for controlling and treatment the nervous system disease is significant, has been Parkinson's, insane
The research of epilepsy, alzheimer's disease, infantile paralysis etc. provides powerful technical support, is increasingly becoming the heat studied both at home and abroad
Point.
At present, the research for neutral net causes the great interest of people, in order to be best understood from central nervous system
In correlation between each core group, producing can be while the electrode for recording multiple core cumularsharolith point Neural spike trains be increasingly becoming
Key technology in neuro-physiology.
For the making mould of such multichannel microelectrode, the method that presently, there are has some shortcomings：First, it is existing
Method for making its electrode accurately, flexibly coordination electrode can not record the number in site, and most of electrode is only limitted to Single locus
Record.Next, it is impossible to size, the shape rolled into a ball according to record core make satisfactory electrod-array mode come specific, with
Ensure that all channel electrode silks entirely fall in specified core group internal.
The content of the invention
In order to solve the shortcoming of prior art, the present invention provides the making mould and its work of a kind of multichannel array microelectrode
Make method, the making mould of the multichannel array microelectrode can reach the mesh of the flexible selection of record site and array way
's.
To achieve the above object, the present invention uses following technical scheme：
A kind of making mould of multichannel array microelectrode, including：
Flat board, which is provided with flat board opening；Device of the flat board opening edge provided with fixed row's female connectors；Flat board both sides
It is respectively fixed with the first location-plate and the second location-plate through flat board, the top of the first location-plate and the second location-plate is with the
One pillar is connected, and the bottom of the first location-plate and the second location-plate is connected with the second pillar；
It is additionally provided with and is parallel to each other and vertical with flat board the 3rd location-plate and the 4th location-plate in flat board opening；First
Post passes through the 3rd location-plate and the 4th location-plate, and the second pillar passes through the 3rd location-plate and the 4th location-plate；3rd location-plate and
Some groups of chromatogram post holes arranged in arrays are additionally provided with 4th location-plate, chromatographic column passes through chromatogram post holes, form chromatographic column battle array
Row.
The chromatographic column array is perpendicular to the 3rd location-plate and the 4th location-plate, for being accurately positioned microelectrode array.
The chromatographic column array is fixed with the 3rd location-plate and the 4th location-plate with PUR.
Close to one end alignment of the chromatographic column array of the device of fixed row's female connectors, each row's length of the other end is passed
Increase arrangement, the wire electrode that the structure to penetrate in chromatographic column is easily pulled out.
3rd location-plate and the 4th location-plate it is equal in magnitude, the structure causes the 3rd location-plate and the 4th location-plate
On chromatogram post holes correspondence it is consistent, be conducive to more being accurately positioned chromatographic column array.
The device of fixed row's female connectors includes some metal columns, and the metal column is fixed on flat board opening edge edge.
3rd location-plate is moved freely along the first pillar and the second pillar, and the 4th location-plate is also along the first pillar and
Two pillars are moved freely.
The flat board opening is rectangular aperture, and it is firm that the structure enables chromatographic column array preferably to be combined with flat board.
A kind of method of work of the making mould of multichannel array microelectrode, including：
The flat board opening edge edge that female connectors are fixed on one end of close chromatographic column array alignment will be arranged；
The form size in record site is rolled into a ball according to nervous system center to determine to entirely fall in the electricity in core group record site
Pole array；
Wire electrode one end is fixed on row's female connectors, the other end of wire electrode penetrates the according to the electrod-array of determination
In three location-plates and the 4th location-plate in corresponding chromatographic column, multichannel array microelectrode is eventually formed.
The wire electrode is fixed on row's female connectors by the way of welding or winding.
Beneficial effects of the present invention are：
(1) the making mould of multichannel array microelectrode of the invention can reach in neatly selection record site
Number, can produce can be while record the electrode in multiple sites.
(2) the form size spy that the making mould of multichannel array microelectrode of the invention can be according to record target core group
Levy to design satisfactory electrod-array mode, can meet intracerebral almost all core group An arrayed recording mode, with up to
Microelectrode silk to all passages entirely falls in the inside of specified core group, solves the shortcoming of electrode fabrication underaction.
Brief description of the drawings
Fig. 1 is the making mould structure schematic diagram of the multichannel array microelectrode of the present invention；
Fig. 2 is the structural representation that chromatographic column array of the invention is connected with the 3rd location-plate and the 4th location-plate.
Wherein, 1, flat board；2nd, flat board opening；3rd, the device of fixed row's female connectors；4th, the first location-plate and the second positioning
Plate, the first location-plate；5th, the second location-plate；6th, the first pillar；7th, the second pillar；8th, the 3rd location-plate；9th, the 4th location-plate；
10th, chromatographic column.
Embodiment
The present invention will be further described with embodiment below in conjunction with the accompanying drawings：
As shown in figure 1, a kind of making mould of multichannel array microelectrode, including：
Flat board 1, which is provided with flat board opening 2；Device 3 of the edge of flat board opening 2 provided with fixed row's female connectors；Flat board
1 both sides are respectively fixed with the first location-plate 4 and the second location-plate 5 through flat board 1, the first location-plate 4 and the second location-plate 5
Top is connected with the first pillar 6, and the bottom of the first location-plate 4 and the second location-plate 5 is connected with the second pillar 7；
It is additionally provided with and is parallel to each other and vertical with flat board 1 the 3rd location-plate 8 and the 4th location-plate 9 in flat board opening 2；The
One pillar 6 passes through the 3rd location-plate 8 and the 4th location-plate 9, and the second pillar 7 passes through the 3rd location-plate 8 and the 4th location-plate 9；
As shown in Fig. 2 some groups of chromatogram post holes arranged in arrays are additionally provided with the 3rd location-plate 8 and the 4th location-plate 9,
Chromatographic column 10 passes through chromatogram post holes, forms chromatographic column array.Wherein, chromatographic column array is fixed perpendicular to the 3rd location-plate 8 and the 4th
Position plate 9, for being accurately positioned microelectrode array.
Chromatographic column array is fixed with the 3rd location-plate 8 and the 4th location-plate 9 with PUR.
Close to one end alignment of the chromatographic column array of the device 3 of fixed row's female connectors, each row's length of the other end
Incremental arrangement, so that the wire electrode penetrated in chromatographic column is easily pulled out.
3rd location-plate 8 and the 4th location-plate 9 it is equal in magnitude, the structure causes the 3rd location-plate 8 and the 4th location-plate 9
On chromatogram post holes correspondence it is consistent, be conducive to more being accurately positioned chromatographic column array.3rd location-plate 8 is along the first pillar 6 and second
Pillar 7 is moved freely, and the 4th location-plate 9 is also moved freely along the first pillar 6 and the second pillar 7.
Wherein, the diameter of chromatographic column 10 may be configured as 300um, also can be set to other sizes according to the actual requirements.
The device 3 of fixed row's female connectors includes some metal columns, and the metal column is fixed on flat board opening edge edge.
Flat board opening 2 is it can also be provided that the opening of various shapes, is preferably arranged to rectangular aperture, so that chromatographic column
Array is preferably combined firm with flat board.
The method of work of the making mould of the multichannel array microelectrode of the present invention, including：
The flat board opening edge edge that female connectors are fixed on one end of close chromatographic column array alignment will be arranged；
The form size in record site is rolled into a ball according to nervous system center to determine to entirely fall in the electricity in core group record site
Pole array；
Wire electrode one end is fixed on row's female connectors, the other end of wire electrode penetrates the according to the electrod-array of determination
In three location-plates and the 4th location-plate in corresponding chromatographic column, multichannel array microelectrode is eventually formed.
Wherein, the form size for rolling into a ball record site according to nervous system center is determined the form of electrod-array, such as 4
× 4 array is constituted or other matrix array forms, is further determined that the distance between the electrode in electrod-array, is finally protected
The electrod-array that card is determined is entirely located in inside core group record site.
The present invention flat board for 18cm × 30cm poly (methyl methacrylate) plate constitute, centre remove 9cm × 11cm part, except
Go to be fixed with 5 metal columns on a side of part, for fixed row's female connectors.
First location-plate, the second location-plate, the use of the 3rd location-plate and the 4th location-plate can select plastic plate；Every group of color
Post is composed all by matrix array mode, such as 4 × 4 array composition or other matrix array forms, every group of chromatographic column one end pair
Together, each row's increasing lengths arrangement of the other end.Chromatographic column array sequentially passes through pre-drilled on two pieces of plastic plate correspondence positions
Square opening, is fixed with PUR.Keep chromatographic column and plastic plate absolute upright.The present invention can utilize welding or the mode wound
Wire electrode is fixed on row's female connectors.
Although above-mentioned the embodiment of the present invention is described with reference to accompanying drawing, not to present invention protection model
The limitation enclosed, one of ordinary skill in the art should be understood that on the basis of technical scheme those skilled in the art are not
Need to pay various modifications or deform still within protection scope of the present invention that creative work can make.
Claims (10)
1. a kind of making mould of multichannel array microelectrode, it is characterised in that including：
Flat board, which is provided with flat board opening；Device of the flat board opening edge provided with fixed row's female connectors；Distinguish flat board both sides
Be fixed with the first location-plate and the second location-plate through flat board, the top of the first location-plate and the second location-plate with first
Post is connected, and the bottom of the first location-plate and the second location-plate is connected with the second pillar；
It is additionally provided with and is parallel to each other and vertical with flat board the 3rd location-plate and the 4th location-plate in flat board opening；First pillar is worn
The 3rd location-plate and the 4th location-plate are crossed, the second pillar passes through the 3rd location-plate and the 4th location-plate；3rd location-plate and the 4th
Some groups of chromatogram post holes arranged in arrays are additionally provided with location-plate, chromatographic column passes through chromatogram post holes, forms chromatographic column array.
2. a kind of making mould of multichannel array microelectrode as claimed in claim 1, it is characterised in that the chromatographic column battle array
Row are perpendicular to the 3rd location-plate and the 4th location-plate.
3. a kind of making mould of multichannel array microelectrode as claimed in claim 1, it is characterised in that the chromatographic column battle array
Row are fixed with the 3rd location-plate and the 4th location-plate with PUR.
4. a kind of making mould of multichannel array microelectrode as claimed in claim 1, it is characterised in that female close to fixed row
One end alignment of the chromatographic column array of the device of connector, each row's increasing lengths arrangement of the other end.
5. a kind of making mould of multichannel array microelectrode as claimed in claim 1, it is characterised in that the 3rd positioning
Plate and the 4th location-plate it is equal in magnitude.
6. a kind of making mould of multichannel array microelectrode as claimed in claim 1, it is characterised in that the fixed row is female
The device of connector includes some metal columns, and the metal column is fixed on flat board opening edge edge.
7. a kind of making mould of multichannel array microelectrode as claimed in claim 1, it is characterised in that the 3rd positioning
Plate is moved freely along the first pillar and the second pillar, and the 4th location-plate is also moved freely along the first pillar and the second pillar.
8. a kind of making mould of multichannel array microelectrode as claimed in claim 1, it is characterised in that the flat board opening
For a rectangular aperture.
9. a kind of method of work of the making mould of multichannel array microelectrode as claimed in claim 1, it is characterised in that bag
Include：
The flat board opening edge edge that female connectors are fixed on one end of close chromatographic column array alignment will be arranged；
The form size in record site is rolled into a ball according to nervous system center to determine to entirely fall in the electrode array in core group record site
Row；
Wire electrode one end is fixed on row's female connectors, the other end of wire electrode penetrates the 3rd according to the electrod-array of determination to be determined
In position plate and the 4th location-plate in corresponding chromatographic column, multichannel array microelectrode is eventually formed.
10. a kind of method of work of the making mould of multichannel array microelectrode as claimed in claim 9, it is characterised in that
The wire electrode is fixed on row's female connectors by the way of welding or winding.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510452157.2A CN105011925B (en) | 2015-07-28 | 2015-07-28 | The making mould and its method of work of a kind of multichannel array microelectrode |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510452157.2A CN105011925B (en) | 2015-07-28 | 2015-07-28 | The making mould and its method of work of a kind of multichannel array microelectrode |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105011925A CN105011925A (en) | 2015-11-04 |
| CN105011925B true CN105011925B (en) | 2017-09-12 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510452157.2A Expired - Fee Related CN105011925B (en) | 2015-07-28 | 2015-07-28 | The making mould and its method of work of a kind of multichannel array microelectrode |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101006920A (en) * | 2007-01-25 | 2007-08-01 | 中国科学院上海微系统与信息技术研究所 | Processing method of three-dimensional implantable microelectrode array |
| CN101112309A (en) * | 2006-07-27 | 2008-01-30 | 中国科学院半导体研究所 | Silicon V-shaped trough plate and method for assembling microfilament electrode array by using the silicon V-shaped trough plate |
| CN103519808A (en) * | 2013-09-18 | 2014-01-22 | 电子科技大学 | Multi-channel microelectrode array and manufacturing method thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009012502A1 (en) * | 2007-07-19 | 2009-01-22 | The Arizona Board Of Regents, A Body Corporate Of The State Of Arizona Acting For And On Behalf Of Arizona State University | Self- anchoring mems intrafascicular neural electrode |
| US8428680B2 (en) * | 2007-10-22 | 2013-04-23 | The Regents Of The University Of Michigan | Hybrid multichannel printed circuit board microdrive |
| US9285336B2 (en) * | 2012-08-09 | 2016-03-15 | The Board Of Trustees Of The Leland Stanford Junior University | Sensing platform for quantum transduction of chemical information |
-
2015
- 2015-07-28 CN CN201510452157.2A patent/CN105011925B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101112309A (en) * | 2006-07-27 | 2008-01-30 | 中国科学院半导体研究所 | Silicon V-shaped trough plate and method for assembling microfilament electrode array by using the silicon V-shaped trough plate |
| CN101006920A (en) * | 2007-01-25 | 2007-08-01 | 中国科学院上海微系统与信息技术研究所 | Processing method of three-dimensional implantable microelectrode array |
| CN103519808A (en) * | 2013-09-18 | 2014-01-22 | 电子科技大学 | Multi-channel microelectrode array and manufacturing method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 帕金森病大鼠丘脑束旁核电信号研究;计义正;《山东师范大学硕士学位论文》;20150401;全文 * |
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| CN105011925A (en) | 2015-11-04 |
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