CN105010933A - Compound nutrition product with liver injury repairing effect - Google Patents
Compound nutrition product with liver injury repairing effect Download PDFInfo
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- CN105010933A CN105010933A CN201410184308.6A CN201410184308A CN105010933A CN 105010933 A CN105010933 A CN 105010933A CN 201410184308 A CN201410184308 A CN 201410184308A CN 105010933 A CN105010933 A CN 105010933A
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Abstract
The invention relates to a novel compound nutrition product with a liver injury repairing effect. According to the product, anthony pig liver peptide powder is selected to be used as the principle raw material, and various nutrients such as choline, inositol, zinc gluconate and methionine of the scientific proportioning, vitamin B, vitamin C and vitamin E are added. The liver injury repairing product is advanced in technology, high in biological activity, and capable of repairing liver injuries for various reasons, promoting hepatic cell regeneration, preventing fat from being accumulated in hepatic cells and enhancing the physiological functions of the liver.
Description
Technical field
The present invention relates to health-oriented products, particularly a kind of have the compound nutritional product repairing hepar damnification effect.
Background technology
Liver carries the critical function sustained life, and is also internal organs maximum in human body.The major function of liver is secretion of bile, stores hepatin, Function protein matter, and the metabolism of fat and carbohydrate also has removing toxic substances, hematopoiesis and hemoglutination.Liver is removing toxic substances organ maximum in human body, and the poisonous substance produced in body, refuse, the poisonous substance eaten into, medicine damaging liver etc. also must pass through liver detoxification.Liver decompose by intestinal absorption or noxious material that other positions of health produce, be then secreted into bile with the form of innocuous substance or blood excretes then.
The reason of hepar damnification is divided into viral, Alcoholic, medicament and LADA.Virus hepatitis causes liver to produce inflammation because infecting hepatitis viruse.Be divided into A, B, C type etc. at present.AML is because continuing the liver damage caused of drinking for a long time.Liver can decomposing alcohol, but frequently drinks in a large number, can cause great burden to liver, infringement liver cell.Medicament hepatitis is the hepar damnification that the side effect produced because of medicine causes.Be divided into toxic liver injury and anaphylaxis hepatic injury.Oneself immunity hepatitis is the abnormal hepatic injury caused of self immune system.Multiple crowd is young woman and climacteric women.
At present, the product category of the reparation hepar damnification on market is various, but large multiaction is single, and pharmacological mechanism is unclear or function is imprecise, and product quality is very different.Therefore in the urgent need to the high-quality liver-protecting product with reliable scientific basis of a new generation.We are according to hepar damnification mechanism, devise a kind of nutrition product with reparation hepar damnification function pointedly.
Described product comprises sucking pig liver Gly-His-Lys, vitamin B complex, choline, inositol, zinc gluconate.The function of each component is as follows:
1) sucking pig liver Gly-His-Lys: extract from sucking pig fresh liver and form various active small molecular protein and peptide growth factor through trypsase catalysis, comprising the HGF (HGSS) that liver cell DNA can be promoted to synthesize.The HGSS mechanism of action is: 1, by changing film ion-transfer mechanism, regulate AMP level in cell, promotes liver cell synthesis; 2, start liver cell DNA by HGSS active gene and liver plasma membrane acceptor interaction to synthesize; 2, strengthen Kupffer's cells function, this cell is macrophage in liver, and the generation of it and endotoxemia, liver failure is closely related, and Sever Hepatitis to have be exactly much Kupffer's cells deterioration; 4, have protective effect to liver cell, HGSS can strengthen liver to amino acid whose picked-up and utilization, even if after cut-out liver, also can provide the energy and raw material for repairing impaired liver.
2) vitamin B complex: help liver detoxification, contribute to bodily tissue and utilize oxygen; The toxin such as alleviation of alcohol and nicotine protection liver.
3) choline: drive the fat factor, helps liver to shift out outside liver by the superabundant fats filled, alleviates burden of liver, recover liver function, and can strengthen memory, prevention senile dementia.In for fatty liver treatment, play very important effect.
4) inositol: promote that phosphatide is formed, ensure the phosphatide demand in hepatopath's body.
5) zinc gluconate: hepatopath's choleresis reduces, and has influence on fat metabolism, thus fat-soluble vitamin absorption is reduced, in hepatopathy patients body, the content of zinc is low simultaneously, and the Absorption And Metabolism of vitamin A also can reduce in ZD situation.Therefore supplement liver to the demand of zinc, can strengthen the absorption to vitamin, to immune reconstruction, liver detoxification, hormone secretion etc. have good effect.
6) ammonium methyl sulfate: important amino acid, protects liver organ vigor effectively, resists free radical (free radical) infringement.
Summary of the invention:
The technical problem to be solved in the present invention overcomes the deficiencies in the prior art, provides a kind of and has the nutrition product repairing hepar damnification effect.
The technical solution used in the present invention is: choosing sucking pig liver Gly-His-Lys is primary raw material, is aided with the various nutrients such as choline, inositol, zinc gluconate, ammonium methyl sulfate and scientific matching multivitamin.
Use the compound product that the present invention relates to, advanced technology, biologically active is stronger, can repair damaged liver, prevents fat from piling up in liver cell, strengthens the various physiological functions of liver.
Its composition of the compound product that the present invention relates to has three parts, that is: one is HGF (HGSS), comes from sucking pig liver extract, and forms through proteases catalyze; Two is degrease medicines, as phosphatide, lipotropin etc.; Three is that several amino acids and vitamin and required mineral matter are as zinc etc.Above-mentioned content constitutes the required composition of health eubolism; Also be simultaneously improve liver function, the liver cell being beneficial to damage repaired, prevent alcohol and poisonous substance to the infringement of liver and fat the deposition in liver cell.
The compound liver-protecting product related in the present invention is applicable to the whirl of society the person of needs that drinks with a guest that drinks more, long-term alcohol person, fatty liver crowd, chronic hepatitis crowd, or the crowd that self liver function is not good enough.
Accompanying drawing illustrates:
Fig. 1: the anatomical structure figure of liver.
Detailed description of the invention:
Below in conjunction with specific embodiment, the invention will be further described, but do not limit protection scope of the present invention.
Preparation technology's flow process of embodiment 1 sucking pig liver Gly-His-Lys
(1) choose fresh sucking pig liver, remove adipose tissue and trunk etc.
(2) adding distil water washing once, and water for injection washs 2 times.
(3) shred in ice bath in clean rustless steel container, homogenate 10 minutes; Add the water for injection of four times, regulate pH to 8.0 ~ 10.0 with alkaline solution.
(4) add 37 DEG C, trypsase 1.5% (g/ml) and hatch 5 hours.
(5) 85 DEG C are heated 30 minutes.
(6) collected by centrifugation supernatant, regulates pH to 5.0 ~ 7.0, film ultrafiltration concentration.Concentrate is loaded in clean bottle.
(7) freeze drier is put, the agent of freeze drying composition.
The hepatic injury of embodiment 2 novel compound repairs product to carbon tetrachloride (CCl
4) protective effect of hepatic injury of inducing
Wistar rat is divided into 5 groups of (Normal group, CCl
4model group, capsule 's content suspension experimental group).Control group and model group with physiological saline gavage, experimental group in 2.2,4.3, the capsule 's content suspension oral gavage of 8.6mg/kg (with sucking pig liver Gly-His-Lys), continuous gavage is after 7 days, model group and experimental group lumbar injection 30%CCl
4olive oil solution (1.5ml/kg), normal group gives equivalent olive oil.
Alanine aminopherase in serum (ALT), asparate aminotransferase (AST), alkaline phosphatase (ALP) is detected after 16 hours; Lesion degree is observed in hepatic tissue Hematoxylin-eosin (HE) dyeing;
Result: compare with control group, the content of CCl4 group serum alt, AST, ALP significantly increases (P < 0.05), and HE dyeing hepatic tissue degeneration necrosis involves full leaflet.With CCl
4group compares, compound liver-protecting suspension+CCl
4the content of group serum alt, AST, ALP significantly declines (P < 0.05); HE staining lesions degree is comparatively light, and degeneration necrosis is confined to the III district of lobuli hepatis.
Conclusion: composition of the present invention all significantly can alleviate CCl
4the hepatic injury of induction, wherein, dosage group is the most remarkable.
Product---capsule is repaired in the hepatic injury of embodiment 3 novel compound
Described a kind of prescription with the novel compound product of liver protecting function consists of:
| 1000 consumptions (g) | |
| Sucking pig liver Gly-His-Lys | 50 |
| Choline | 20 |
| Inositol | 12 |
| Zinc gluconate | 3 |
| MET | 12 |
| Powdered vitamin E (by vitamin E) | 12IU |
| Vitamin C | 10 |
| Vitamin B1 | 1.2 |
| Vitamin B2 | 1.2 |
| Vitamin B3 | 12 |
| Vitamin B5 | 2 |
| Vitamin B6 | 0.6 |
| VB11 | 0.08 |
| Vitamin B12 | 0.01 |
| Sweet mellow wine | 50 |
| Low-substituted hydroxypropyl cellulose | 50 |
| Talcum powder | 2 |
Preparation method: by prescription, gets choline, inositol, zinc gluconate, MET, powdered vitamin E, vitamin C, vitamin B complex, with sweet mellow wine grinding, mix, then add low-substituted hydroxypropyl cellulose, sucking pig liver Gly-His-Lys, mix, add talcum powder and mix.Be packed into Capsules, obtain final product.Every by sucking pig liver Gly-His-Lys, containing sucking pig liver Gly-His-Lys 50mg.
Claims (4)
1. there is the novel compound nutrition product repairing hepar damnification effect, it is characterized in that: this product contains sucking pig liver Gly-His-Lys, and adds choline, inositol, zinc gluconate, MET, vitamin B complex, the various nutrients such as E and C.
2. a kind of according to claim 1 have the novel compound nutrition product repairing hepar damnification effect, it is characterized in that described sucking pig liver Gly-His-Lys is that the freeze drying of sucking pig orgotein protease hydrolysate forms.
3. the preparation method of a kind of sucking pig liver Gly-His-Lys according to claim 2, comprises the steps: to choose fresh sucking pig liver, shreds in clean rustless steel container under ice bath, homogenate 10 minutes.Add the water for injection of four times, regulate pH to 8.0 ~ 10.0 with alkaline solution.Add 37 DEG C, trypsase 1.5% (g/ml) and hatch 5 hours.85 DEG C are heated 30 minutes.Collected by centrifugation supernatant, regulates pH to 5.0 ~ 7.0, film ultrafiltration concentration.Concentrate is loaded in clean bottle, puts freeze drier, and freeze drying becomes sucking pig liver Gly-His-Lys.
4. a kind of preparation method with the product of hepar damnification repair function described in claim 1-2, comprise the steps: to add each component successively according to formula, add sweet mellow wine, low-substituted hydroxypropyl cellulose, talcum powder, mixing, be packed into Capsules, every containing sucking pig liver Gly-His-Lys 50mg, choline 20mg, inositol 12mg, zinc gluconate 3mg, MET 12mg, vitamin e1 2IU, vitamin C 10mg, vitamin B1 1.2mg, vitamin B2 1.2mg, vitamin B3 12mg, vitamin B5 2mg, vitamin B6 0.6mg, VB11 0.08mg, vitamin B12 0.01mg.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410184308.6A CN105010933A (en) | 2014-04-29 | 2014-04-29 | Compound nutrition product with liver injury repairing effect |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410184308.6A CN105010933A (en) | 2014-04-29 | 2014-04-29 | Compound nutrition product with liver injury repairing effect |
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| Publication Number | Publication Date |
|---|---|
| CN105010933A true CN105010933A (en) | 2015-11-04 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410184308.6A Pending CN105010933A (en) | 2014-04-29 | 2014-04-29 | Compound nutrition product with liver injury repairing effect |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110179107A (en) * | 2019-07-01 | 2019-08-30 | 北京东方倍力营养科技有限公司 | A kind of complete nutritional composition improving liver function and liver fibrosis |
| CN111772188A (en) * | 2020-07-07 | 2020-10-16 | 河北智同生物制药股份有限公司 | Liver polypeptide for protecting liver and improving liver function and composition thereof |
-
2014
- 2014-04-29 CN CN201410184308.6A patent/CN105010933A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110179107A (en) * | 2019-07-01 | 2019-08-30 | 北京东方倍力营养科技有限公司 | A kind of complete nutritional composition improving liver function and liver fibrosis |
| CN111772188A (en) * | 2020-07-07 | 2020-10-16 | 河北智同生物制药股份有限公司 | Liver polypeptide for protecting liver and improving liver function and composition thereof |
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| Date | Code | Title | Description |
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| C06 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20151104 |
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| WD01 | Invention patent application deemed withdrawn after publication |