CN104997482B - Implementation method and device are followed up a case by regular visits in a kind of straight line high definition scanning - Google Patents
Implementation method and device are followed up a case by regular visits in a kind of straight line high definition scanning Download PDFInfo
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- CN104997482B CN104997482B CN201510471924.4A CN201510471924A CN104997482B CN 104997482 B CN104997482 B CN 104997482B CN 201510471924 A CN201510471924 A CN 201510471924A CN 104997482 B CN104997482 B CN 104997482B
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- 238000000034 method Methods 0.000 title claims abstract description 33
- 230000003287 optical effect Effects 0.000 claims abstract description 226
- 238000006073 displacement reaction Methods 0.000 claims abstract description 67
- 210000001508 eye Anatomy 0.000 claims description 42
- 210000004204 blood vessel Anatomy 0.000 claims description 10
- 230000008878 coupling Effects 0.000 claims description 8
- 238000010168 coupling process Methods 0.000 claims description 8
- 238000005859 coupling reaction Methods 0.000 claims description 8
- 241000208340 Araliaceae Species 0.000 claims description 2
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims description 2
- 235000003140 Panax quinquefolius Nutrition 0.000 claims description 2
- 235000008434 ginseng Nutrition 0.000 claims description 2
- 230000008859 change Effects 0.000 abstract description 3
- 238000012014 optical coherence tomography Methods 0.000 description 47
- 230000003595 spectral effect Effects 0.000 description 8
- 238000001514 detection method Methods 0.000 description 6
- 230000008569 process Effects 0.000 description 6
- 230000005012 migration Effects 0.000 description 5
- 238000013508 migration Methods 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 3
- 230000004418 eye rotation Effects 0.000 description 3
- 231100000915 pathological change Toxicity 0.000 description 3
- 230000036285 pathological change Effects 0.000 description 3
- 238000010408 sweeping Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 238000003556 assay Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000005252 bulbus oculi Anatomy 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000011086 high cleaning Methods 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 230000029052 metamorphosis Effects 0.000 description 1
- 230000010363 phase shift Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
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Abstract
The invention discloses that implementation method and device are followed up a case by regular visits in a kind of straight line high definition scanning, method comprises determining that the first nodal point position (x1, y1) of high definition scanned straight lines, scanning angle (a1) and First Line scanning laser optical fundus figure；High definition scanned straight lines scans optical fundus with (x1, y1) and scanning angle, obtains some second line scanning laser optical fundus figures, they are mated one by one with First Line scanning laser optical fundus figure respectively, obtain some groups of offset displacements, therefrom count the first displacement (Δ xn, Δ yn)；First Line is scanned laser optical fundus figure and the 3rd line scanning laser optical fundus figure registration, resets the center position of high definition scanned straight lines according to registration result；High definition scanned straight lines scanning optical fundus, several optical fundus OCT image of computer acquisition, complete straight line and follow up a case by regular visits to.The present invention can reduce the hardware requirement to computer, cannot provide the hardware system that can change scan position in real time in OCT system in the case of, can realize, to human eye same position accurate scan, having saved cost equally within the different time.
Description
Technical field
The invention belongs to ophthalmology OCT image process field, be specifically related to a kind of straight line high definition scanning and follow up a case by regular visits to reality
Existing method and device.
Background technology
Currently with OCT (Optical Coherence Tomography, Optical coherence tomography)
Follow up a case by regular visits to human eye optical fundus and have two kinds of implementations: sector scanning and dynamic ocular pursuit.For sector scanning, due to OCT
The sweep limits of scanning element is relatively big, if after therefore optical fundus general direction being scanned again in the later stage to sweeping
Retouch Registration of Measuring Data, the i.e. available contrast of same location testing result accurately.But the image of sector scanning is imitated
Fruit is generally scanned not as straight line high definition, and therefore the grasp of optical fundus metamorphosis is more desirable to use straight line high by doctor
Clean the follow-up method retouched to carry out.
Following up a case by regular visits to for straight line high definition scanning, current implementation method is to utilize dynamic ocular pursuit technology, supervises in real time
Survey eye fundus image and contrast with the eye fundus image obtained before, find the detection position of last time in real time and examine
Survey and contrast, if patent publication No. is the patent of 103429142A.This mode is to the hardware of OCT system
Require the highest, be mainly manifested in real-time ocular fundus image registration and real-time scan position changes, add skill
Art realizes difficulty.In patent application document, the meaning of " following up a case by regular visits to " is to utilize OCT system Multiple-Scan eye
Same position, the end, say, that OCT system needs meet on different time interscan human eye optical fundus same
Position, to observe the pathological changes situation at this position.
Summary of the invention
The invention provides a kind of straight line high definition scanning and follow up a case by regular visits to implementation method and device, its object is to provide
When a kind of hardware system when OCT device cannot accomplish to change in real time scanning orientation, optical fundus, it is right to realize equally
Optical fundus same position accurately follows up a case by regular visits to the technical scheme of scanning.
The technical scheme of the device that the present invention announces is as follows:
Implementation method is followed up a case by regular visits in a kind of straight line high definition scanning, comprises the steps:
The first nodal point position (x1, y1) of the high definition scanned straight lines of storage, scan angle is found out from computer
Degree (a1) and First Line scanning laser optical fundus figure；
Add up the first displacement (Δ xn, Δ yn), including: described high definition scanned straight lines is with described first center
Point position (x1, y1) and described scanning angle (a1) scanning optical fundus, obtain some second line scanning laser eyes
Described some second line scanning laser optical fundus figures are scanned laser optical fundus figure one with described First Line by base map respectively
One coupling, obtains some groups of offset displacements；Computer counts appearance frequency from described some groups of offset displacements
The first displacement (Δ xn, Δ yn) that rate is the highest；
Described First Line scanning laser optical fundus figure is offset with described first displacement (Δ xn, Δ yn), then
Registrate with the 3rd line scanning laser optical fundus figure, reset in high definition scanned straight lines according to registration result
Heart point position；Wherein, described 3rd line scans laser optical fundus figure by described high definition scanned straight lines with described first
Center position (x1, y1) and described scanning angle (a1) scanning optical fundus obtain；
Described high definition scanned straight lines is swept with the described center position reset and described scanning angle (a1)
Retouch optical fundus, computer acquisition some width optical fundus OCT image, complete straight line and follow up a case by regular visits to.
Further: the described center position resetting high definition scanned straight lines according to registration result, specifically walk
Rapid as follows:
If described First Line scanning laser optical fundus figure and described 3rd line scanning laser optical fundus figure registration are correct, return
Go back to computer acquisition interface, reset the second center position (x1+ Δ of described high definition scanned straight lines
xn,y1+Δyn)；
If described First Line scanning laser optical fundus figure and described 3rd line scanning laser optical fundus figure registration mistake, hands
Dynamic mobile described First Line scanning laser optical fundus figure, is offset the second displacement (Δ xp, Δ yp)；Return
Computer acquisition interface, resets the 3rd center position (x1+ Δ xp, the y1+ of described high definition scanned straight lines
Δyp)。
Further: described registration is by described First Line scanning laser optical fundus figure and described 3rd line being swept
Retouch the same object of reference in the figure of laser optical fundus and carry out what coupling realized.
Further: described object of reference includes blood vessel or optic disc.
Further: several second lines described scanning laser optical fundus figure, is each width at Computer display
Collect after second line scanning laser optical fundus figure all has optical fundus figure.
Further: described some second lines scanning laser optical fundus figures are scanned laser with described First Line respectively
Optical fundus figure registrates one by one, and its registration result is higher than threshold value.
Further: described high definition scanned straight lines is with described first nodal point position (x1, y1) and described scanning
Angle (a1) scanning optical fundus, while obtaining some second line scanning laser optical fundus figures, if being also obtained
Dry width OCT image.
Further: trying to achieve of described some groups of offset displacements, it is by by described some second line scanning laser
Second pixel at figure center, optical fundus arrives first pixel at described First Line scanning figure center, laser optical fundus respectively
Pixel distance, be converted into what physical distance obtained.
The present invention also disclosed a kind of straight line high definition scanning and follows up a case by regular visits to realize device, including:
Follow up a case by regular visits to confirm module, be used for: confirm that storage high definition scanned straight lines in a computer completes to scan optical fundus
Time first nodal point position (x1, y1), scanning angle (a1) and First Line scanning laser optical fundus figure；
Statistical module, is used for: divided by the described some second line scanning laser optical fundus figures including eye fundus image
Other and described First Line scanning laser optical fundus figure registration, obtains some groups of displacements, from described some groups of displacements
Count the first the highest displacement of the frequency of occurrences (Δ xn, Δ yn)；
Registration confirms module, for scanning the described First Line after offseting the first displacement (Δ xn, Δ yn)
Laser optical fundus figure carries out registration with the identical object of reference of described 3rd line scanning laser optical fundus figure and confirms；
OCT image acquisition module, is used for: when the first nodal point position (x1, y1) of described high definition scanned straight lines
The second center position (x1+ Δ xn, y1+ Δ yn) or the 3rd center position (x1+ is become through skew
Δ xp, y1+ Δ yp) after, high definition scanned straight lines scans human eye optical fundus with described scanning angle (a1), gathers
Several optical fundus OCT image.
Further: described registration result has a threshold value judged；When each width collected all is comprised
Some second line scanning laser optical fundus figures of optical fundus figure, respectively with described First Line scanning laser optical fundus figure registration
Time, the registration result of each group obtained is above described threshold value.
Further: described each width all comprises some second lines scanning laser optical fundus figures of optical fundus figure, be
After having eye fundus image in described second line scanning laser optical fundus figure, computer connected within the time period arranged
Continuous collect.
Implementation method and device are followed up a case by regular visits in a kind of straight line high definition scanning that the present invention announces, and can find computer in real time
Last detection position and carry out detection contrast, equally can reach to utilize dynamic ocular pursuit technology to realize straight line
High definition scans the purpose followed up a case by regular visits to.But to computer hardware, this method and device require that ratio is relatively low, in OCT system
System cannot provide in the case of meeting the hardware system changing scan line scan position in real time, and it is right to realize equally
Same position accurately follows up a case by regular visits to scanning.Therefore, the method and device reduce cost and the meter of OCT device
Calculation machine hardware requirement, has saved cost.
Accompanying drawing explanation
Fig. 1 is the flow chart of the present invention；
Fig. 2 is the First Line scanning laser optical fundus figure being stored in；
The right of Fig. 3 is the second line scanning laser optical fundus figure including eye fundus image of Real-time Collection, the left side
For the optical fundus OCT image gathered simultaneously；
Fig. 4 is that First Line scanning laser optical fundus figure carries out migration process schematic diagram；
Fig. 5 is after the 3rd line scanning laser optical fundus figure (not shown) with computer real-time acquisition completes registration
First Line scanning laser optical fundus figure；
The image on the right of Fig. 6 is shown as, after First Line scanning laser optical fundus figure completes registration, again offseting
High definition scanned straight lines, obtains its second center position (x1+ Δ xn, y1+ Δ yn) or the 3rd central point
The process schematic of position (x1+ Δ xp, y1+ Δ yp)；Left-hand component is then to offset at high definition scanned straight lines
After, the optical fundus OCT tomograph that OCT system scanning optical fundus collects；
Fig. 7 is that the scanning of straight line high definition follows up a case by regular visits to realize apparatus module figure；
Fig. 8 is the light path sketch of OCT system.
Detailed description of the invention
In order to make the technical problem to be solved, technical scheme and beneficial effect clearer,
Below in conjunction with drawings and Examples, the present invention is further elaborated.Should be appreciated that this place is retouched
The specific embodiment stated only in order to explain the present invention, is not intended to limit the present invention.
With reference to Fig. 8, in the present patent application, OCT system includes: light source 100, spectral module 200, ginseng
Examine arm module 300, sample arm module 500, detecting module 600 and control system 700.The work of OCT system
Making principle as follows: the light that light source 100 sends is transferred to spectral module 200, spectral module 200 will receive
Light be divided into reference light and detection light, wherein reference light passes to reference arm module 300, and detection light passes to
Sample arm module 500.The reference light received is transferred back to spectral module by reference arm module 300 after reflection
200；Detection light, after collimating mirror 400 collimates, scans eyes 800, through eye after sample arm module 500
Form flashlight after tissue scatter in eyeball 800 and the most collimated mirror 400 returns spectral module 200, letter
Number light and reference light form interference light after interfering at spectral module 200.Detecting module 600 receives interferes light
After, will interfere light signal transmit to control system 700, control system 700 processes this signal, obtain by
The position phase shift signal of the tissue of the eyes of scanning.Wherein, reference arm module 300 is built-in with reference mirror 301,
The reference light that spectral module 200 light splitting obtains returns in spectral module 200 after reference mirror 301 reflects,
Interfere at this and flashlight.Specifically, reference mirror 301 prioritizing selection is plane mirror.This place
The control system 700 said is it can be understood as computer.
Describe the scanning of straight line high definition with reference to Fig. 1, Fig. 1 and follow up a case by regular visits to the flow process of implementation method.
S101: find out the first nodal point position (x1, y1) of the high definition scanned straight lines of storage from computer, sweep
Retouch angle (a1) and First Line scanning laser optical fundus figure.
Specifically, after OCT system has performed the scanning of straight line high definition every time, it is built in OCT system
The first nodal point position (x1, y1) of the scanned straight lines in software records OCT system, scanning angle (a1)
With First Line scanning laser optical fundus figure (as shown in Figure 2).They are retained in a computer, the when of needs
Use can be recalled at any time.
According to the scanning area to human eye optical fundus shown by Fig. 2, under the cooperation of testee, test person
The scanning element of member's operation OCT system enters the scanning area of human eye, this scanning area and be stored in computer
In First Line scanning laser optical fundus figure shown by identical by the scanning area of scanning staff.Then, by height
The center position of clear scanned straight lines is also configured to (x1, y1), and scanning angle is also configured to a1, i.e. and calculate
In machine software, the first nodal point position (x1, y1) of record is identical with scanning angle (a1).
S102, add up the first displacement (Δ xn, Δ yn), including: described high definition scanned straight lines is with described
One center position (x1, y1) and described scanning angle (a1) scanning optical fundus, obtain some second line scanning
Described some second line scanning laser optical fundus figures are scanned laser eye with described First Line by laser optical fundus figure respectively
Base map mates one by one, obtains some groups of offset displacements；Computer counts from described some groups of offset displacements
The first displacement (Δ xn, Δ yn) that the frequency of occurrences is the highest.
Specifically, after completing the preparation of step S101, operator control OCT system, high cleaning
Retouch straight line with first nodal point position (x1, y1) and scanning angle (a1), optical fundus to be scanned, obtain computer
The scanning of the line as shown on the right of Fig. 3 laser optical fundus figure that display interface shows in real time, and obtain such as Fig. 3 simultaneously
Some width OCT image shown in the left side.But, this line scanning laser optical fundus figure can not show at the very start
Go out good optical fundus figure, line scanning laser optical fundus figure the most now can not elect for the in Fig. 2
One line scanning laser optical fundus figure registration.The scanning means (not shown) of OCT system continues to scan optical fundus,
During until line scanning laser optical fundus figure has eye fundus image, computer in short time period (preferably 2 seconds
Clock) gather some each width and all include the second line scanning laser optical fundus figure of eye fundus image.Therefore, second
Line scanning laser optical fundus figure does not obtains at the very start, is to need to go out ratio in Computer display interface display
Preferably collect after eye fundus image.The most why require to gather at short notice, be in order to prevent by
Part the second line scanning laser optical fundus figure and First Line scanning laser optical fundus figure that survey person's eye rotation causes are carried out
Registration, the offset displacement tried to achieve is inaccurate.
Then some width are included the second line scanning laser optical fundus figure and the First Line scanning laser of eye fundus image
Optical fundus figure mates respectively, obtains some groups of offset displacement displacements, and each group of offset displacement is the most corresponding every
Width includes the second line scanning laser optical fundus figure and the coupling knot of First Line scanning laser optical fundus figure of eye fundus image
Really.As: the skew of the registration of first the second line scanning laser optical fundus figure and First Line scanning laser optical fundus figure
Displacement is (Δ x1, Δ y1), second the second line scanning laser optical fundus figure and First Line scanning laser optical fundus figure
The offset displacement of registration be (Δ x2, Δ y2), the 3rd the second line scanning laser optical fundus figure and First Line are swept
The offset displacement retouching laser optical fundus figure registration is (Δ x3, Δ y3) ... by that analogy, and (m is certainly to m
So number) the registration offset displacement of the second line scanning laser optical fundus figure and First Line scanning laser optical fundus figure is (Δ
Xm, Δ ym). from this m group offset displacement, it may be assumed that (Δ x1, Δ y1), (Δ x2, Δ y2), (Δ x3, Δ
... (Δ xm, Δ ym), y3) the highest displacement of the frequency of occurrences (Δ xn, Δ yn) is counted as first
Displacement.Such as, if (Δ x1, Δ y1) is (2,3), (Δ x2, Δ y2) is (2,3), (Δ x10,
Δ y10) also it is (2,3), and, the frequency that displacement (2,3) occurs in m group displacement is most, then
The value of (Δ xn, Δ yn) takes (2,3), therefore can be by (2,3) as the center of high definition scanned straight lines
First offset displacement of position skew.Owing to this m group offset displacement is that continuous acquisition obtains in short time period,
Thus the incorrect consequence of matching result preventing eye rotation to cause, say, that this m group bits of offset
It is correct that shifting value calculates.
It should be noted that trying to achieve of described some groups (i.e. m group) offset displacements, it is each by choosing
Second pixel of the center of the second line scanning laser optical fundus figure, swashs with the scanning of described First Line respectively
First pixel at the center of light optical fundus figure carries out what position calculation obtained.The most first choose and be positioned at First Line scanning
First pixel of the center of laser optical fundus figure is reference, chooses any one the second line scanning the most again
Second pixel of the center of laser optical fundus figure, by by each group of the second pixel to the first pixel
Pixel distance be converted into the physical distance of the second pixel to the first pixel and try to achieve.Same, other is inclined
It is also to obtain by same way that displacement moves.
It should be noted that the registration result of each group of displacement must have a threshold value judged.Only when
When optical fundus figure occurs in scanning laser optical fundus figure in two wires, the some width collected are included the of optical fundus figure
Scanning laser optical fundus, two wires figure registrates with First Line scanning laser optical fundus figure respectively, and its registration result is just higher than threshold
Value.
S103: described First Line scanning laser optical fundus figure is offset with described first displacement (Δ xn, Δ yn),
Then registrate with the 3rd line scanning laser optical fundus figure, reset high definition scanned straight lines according to registration result
Center position；Wherein, described 3rd line scans laser optical fundus figure by described high definition scanned straight lines with described
First nodal point position (x1, y1) and described scanning angle (a1) scanning optical fundus obtain.
Specifically, from computer, the First Line scanning laser optical fundus figure of the storage shown in Fig. 2, reference are recalled
Fig. 4, on the basis of the center of this image, is that side-play amount is to this with the first displacement (Δ xn, Δ yn)
Image offsets, and the 3rd line scanning of the First Line scanning laser optical fundus figure after skew and Real-time Collection is swashed
Light optical fundus figure (because the scanning means of OCT system is constantly in duty, can the most constantly gather
Optical fundus figure；3rd line scanning laser optical fundus figure is not shown) registration.If First Line scanning laser optical fundus figure and
3rd line scanning laser optical fundus figure registration is correct, the first nodal point (x1, y1) of high definition scanned straight lines is offset
(Δ xn, Δ yn), becomes the second central point (x1+ Δ xn, y1+ Δ yn).It should be noted that the 3rd
Line scanning laser optical fundus figure is also with first nodal point position (x1, y1) and scanning angle by high definition scanned straight lines
(a1) scanning optical fundus obtains, because when obtaining the 3rd line scanning laser optical fundus figure, and high definition scanned straight lines
Center position have not occurred skew, be also (x1, y1), scanning angle does not changes yet.
But, if it find that First Line scanning laser optical fundus map migration (Δ xn, Δ yn) is swept with the 3rd line afterwards
Retouch laser optical fundus figure registration incorrect, then need manually or other manual operations drag First Line scanning
Laser optical fundus figure, scans laser optical fundus figure overall offset the second displacement (Δ xp, Δ yp) by First Line.So
After the first nodal point (x1, y1) of high definition scanned straight lines is offset (Δ xp, Δ yp), become the 3rd center
Point (x1+ Δ xp, y1+ Δ yp).
S104, described high definition scanned straight lines are with the described center position reset and scanning angle (a1)
Scanning optical fundus, computer acquisition some width optical fundus OCT image, complete straight line and follow up a case by regular visits to.
With reference to right-hand part part of Fig. 6, after completing step S103, by the first nodal point of high definition scanned straight lines
(x1, y1) re-starts setting, becomes the second central point (x1+ Δ xn, y1+ Δ yn) or the 3rd center
Point (x1+ Δ xp, y1+ Δ yp).Then high definition scanned straight lines scans optical fundus, computer with scanning angle a1
Collect several OCT image as shown in Fig. 6 left portion.In gatherer process, if patient's eyes is moved,
Computer then suspends collection, until patient's eyes playbacks again, computer has gathered several OCT figure again
After automatically into assay surface, complete the collection that straight line is followed up a case by regular visits to.
It should be noted that mention in step s 103: by described First Line scanning laser optical fundus figure with
Described first displacement (Δ xn, Δ yn) offsets, and then the 3rd line with Real-time Collection scans laser optical fundus figure
Registrating, the essence of its registration is that the same object of reference choosing line scanning laser optical fundus figure registrates.Example
As, choose a certain blood vessel and the 3rd line scanning laser eye of the First Line scanning laser optical fundus figure shown in Fig. 2
The same blood vessel of base map (not shown) registrates, it is also possible to choose the First Line scanning laser eye in Fig. 2
The optic disc of the optic disc of base map and the 3rd line scanning laser optical fundus figure (not shown) registrates.Certainly, blood vessel
Selection with optic disc is the most symbolistic, it is also possible to select other the identical objects of reference in the figure of optical fundus to carry out
Registration.Same, First Line is scanned laser optical fundus map migration the first displacement (Δ xn, Δ yn) afterwards with reality
Time the principle of the 3rd line scanning laser optical fundus figure registration that gathers and as above, be not repeated at this.
In sum, the first center of the high definition scanned straight lines that storage stores in a computer is first called
(x1, y1), scanning angle (a1) and First Line scanning laser optical fundus figure；The high definition scanned straight lines of OCT system
Human eye optical fundus is scanned with same center (x1, y1) and same scanning angle (a1)；When the second line
When scanning laser optical fundus figure has eye fundus image, in certain period of time, gather several second lines sweep
Retouching laser optical fundus figure, wherein, each the second line scanning laser optical fundus figure all includes eye fundus image；Pass through
Several second lines scanning laser optical fundus figure is registrated one by one with First Line scanning laser optical fundus figure respectively, obtains
If m group displacement: (Δ x1, Δ y1), (Δ x2, Δ y2), (Δ x3, Δ y3) ... (Δ xm, Δ ym),
From this m group displacement, choose the most displacement of the frequency of occurrences (Δ xn, Δ yn) scan laser as First Line
First displacement of optical fundus map migration；First Line is scanned laser optical fundus map migration (Δ xn, Δ yn), will skew
After First Line scanning laser optical fundus figure and high definition scanned straight lines with same center (x1, y1) and equally
The 3rd line scanning laser optical fundus figure registration that obtains of scanning angle (a1) scanning human eye optical fundus；When finding first
When line scanning laser optical fundus figure and the 3rd line scanning laser optical fundus figure registration are correct, by the of high definition scanned straight lines
One center position (x1, y1) obtains the second center position by offseting the first displacement (Δ xn, Δ yn)
(x1+Δxn,y1+Δyn)；When finding First Line scanning laser optical fundus figure and the 3rd line scanning laser optical fundus figure
During registration mistake, manually drag First Line scanning laser optical fundus figure, make it offset the second displacement (Δ xp, Δ
Yp), then by the first nodal point position (x1, y1) of high definition scanned straight lines by offset the second displacement (Δ xp,
Δ yp), obtain the 3rd center position (x1+ Δ xp, y1+ Δ yp)；Finally, high definition scanned straight lines is with scan angle
Degree a1 scans optical fundus, obtains several OCT image, completes straight line and follow up a case by regular visits to.
It should be noted that by the First Line scanning laser optical fundus figure after skew and the 3rd line scanning laser optical fundus
Figure registration, is that the same object of reference choosing two width line scanning laser optical fundus figures registrates.For example, referring to thing
The same blood vessel that can select two width line scanning laser optical fundus figures registrates, it is also possible to select optic disc to be used for
Registration.Certainly, the selection of blood vessel and optic disc is merely exemplary, it is also possible to choose other images in figure
Feature registrates.
Therefore, a certain concrete position of human eye can be scanned before finding OCT system accurately by this method,
And this position is gathered several OCT image again, to judge the pathological changes situation at this position.It is to say,
The method is utilized to be separated by front and back in long time, also can be to a certain concrete same area of human eye
Realize accurately accessing.But the hardware that this method is to computer (being equivalent to the control system 700 in Fig. 8)
Require that ratio is relatively low, in the case of the hardware system that can change scan position in real time cannot be provided in OCT system, with
Sample accomplishes accurately to follow up a case by regular visits to same position scanning.Therefore, the method can reduce OCT as shown in Figure 8
The cost of system.
With reference to Fig. 7, the present invention also disclosed a kind of straight line high definition scanning and follows up a case by regular visits to realize device, including: follow up a case by regular visits to
Confirm that module, determination module, statistical module, registration confirm module and OCT image acquisition module.
Follow up a case by regular visits to confirm module, for confirming to store the first nodal point position of high definition scanned straight lines in a computer
Put (x1, y1), scanning angle (a1) and First Line scanning laser optical fundus figure (as shown in Figure 2).When really
After recognizing these information, under the cooperation of testee, operator controls computer and enters scanning interface.
Statistical module, for from some groups of offset displacements (Δ x1, Δ y1), (Δ x2, Δ y2), (Δ x3,
Δ y3) ... in (Δ xm, Δ ym), count that group offset displacement (Δ xn, Δ that the frequency of occurrences is the highest
Yn) as the first displacement.Specifically, after entering scanning interface, the high definition scanned straight lines of OCT system is swept
Retouch the optical fundus of tested personnel, when the 3rd line scanning laser optical fundus figure occurs on the display interface of computer,
Part ocular fundus image registration amount of movement in order to prevent measured's eye rotation from causing is inaccurate, sweeping of computer
Imaging apparatus is (preferably 2 seconds) scanning optical fundus within the time period arranged, and obtains each width and all includes eye
Some the second lines scanning laser optical fundus figure (see Fig. 3) of base map picture.Then some width are included optical fundus figure
Second line scanning laser optical fundus figure and the First Line scanning laser optical fundus figure of picture registrate respectively, obtain some
Group offset displacement (Δ x1, Δ y1), (Δ x2, Δ y2), (Δ x3, Δ y3) ... (Δ xm, Δ ym).
Owing to computer can not can obtain good optical fundus figure at the very start, therefore for the second line scanning laser eye
Choosing of base map must have a threshold value judged.When the optical fundus preview graph of display in real time has eye fundus image,
Some the second lines scanning laser optical fundus figures are gathered, by them respectively with the within the time period of computer settings
One line scanning laser optical fundus figure coupling, the result therefore registrated is higher than threshold value.
It should be noted that some second lines scanning laser optical fundus figures of eye fundus image will be included respectively and institute
State First Line scanning laser optical fundus figure to mate one by one, try to achieve some groups of offset displacements (Δ x1, Δ y1), (Δ
X2, Δ y2), (Δ x3, Δ y3) ... (Δ xm, Δ ym's) method particularly includes: first choose First Line and sweep
Retouch the pixel of center of laser optical fundus figure as the first pixel；Then choose any one width to include
The pixel of the center of the second line scanning laser optical fundus figure of eye fundus image is as the second pixel；By
Two pixels are converted into physical distance to the pixel distance of the first pixel, are the respective offsets displacement tried to achieve
Value.Same, other offset displacement value can also be obtained by this way.
Registration confirms module, for the First Line after offseting the first displacement (Δ xn, Δ yn) is scanned laser
3rd line scanning laser optical fundus figure (not shown) of optical fundus figure (see Fig. 2) and computer real-time acquisition is carried out
Registration confirms.Specifically, its method for registering be choose First Line scanning laser optical fundus figure and the 3rd line scanning swash
The same object of reference of light optical fundus figure registrates, and such as, First Line scans a certain bar in the figure of laser optical fundus
The same blood vessel of blood vessel and the 3rd line scanning laser optical fundus figure registrates.Other objects of reference can also be selected
As optic disc is used for registrating.Certainly, object of reference can also choose other characteristics of image of line scanning laser optical fundus figure
Registrating, the selection of blood vessel and optic disc is merely exemplary.It should be noted that the 3rd line scanning swashs
The acquisition of light optical fundus figure is also with first nodal point position (x1, y1) and scanning angle by high definition scanned straight lines
(a1) scan what optical fundus obtained.Because now the center of high definition scanned straight lines has not occurred skew.
OCT image acquisition module, is used for gathering OCT image.Specifically, when the first of high definition scanned straight lines
Center position (x1, y1) becomes the second center position (x1+ Δ x through resettingn,y1+Δyn)
Or after the 3rd center position (x1+ Δ xp, y1+ Δ yp), high definition scanned straight lines scanning optical fundus, calculate
Machine gathers the optical fundus OCT image of some numbers.
The straight line high definition scanning that the present invention announces follows up a case by regular visits to realize device, therefore, can be looked for accurately by this device
Before OCT system, scan a certain concrete position of human eye, and this position is gathered again several OCT figure
Picture, to judge the pathological changes situation at this position.It is to say, it is the longest to utilize this device can be separated by front and back
In time, also can realize accurately following up a case by regular visits to a certain concrete same area of human eye.But this device is to calculating
The hardware requirement ratio of machine (being equivalent to the control system 700 in Fig. 8) is relatively low, cannot provide in OCT system
In the case of changing the hardware system of scan line scan position in real time, accomplish equally accurately same position to be carried out
Follow up a case by regular visits to scanning.Therefore, this device can reduce the cost of OCT system as shown in Figure 8.
The foregoing is only presently preferred embodiments of the present invention, not in order to limit the present invention, all at this
Any amendment, equivalent and the improvement etc. made within bright spirit and principle, should be included in the present invention
Protection domain within.
Claims (11)
1. implementation method is followed up a case by regular visits in a straight line high definition scanning, it is characterised in that: comprise the steps:
The first nodal point position (x1, y1) of the high definition scanned straight lines of storage, scan angle is found out from computer
Degree (a1) and First Line scanning laser optical fundus figure；
Add up the first displacement (Δ xn, Δ yn), including: described high definition scanned straight lines is with described first center
Point position (x1, y1) and described scanning angle (a1) scanning optical fundus, obtain some second line scanning laser eyes
Described some second line scanning laser optical fundus figures are scanned laser optical fundus figure one with described First Line by base map respectively
One coupling, obtains some groups of offset displacements；Computer counts appearance frequency from described some groups of offset displacements
The first displacement (Δ xn, Δ yn) that rate is the highest；
Described First Line scanning laser optical fundus figure is offset with described first displacement (Δ xn, Δ yn), then
Registrate with the 3rd line scanning laser optical fundus figure, reset in high definition scanned straight lines according to registration result
Heart point position；Wherein, described 3rd line scans laser optical fundus figure by described high definition scanned straight lines with described first
Center position (x1, y1) and described scanning angle (a1) scanning optical fundus obtain；
Described high definition scanned straight lines is swept with the described center position reset and described scanning angle (a1)
Retouch optical fundus, computer acquisition some width optical fundus OCT image, complete straight line and follow up a case by regular visits to.
2. implementation method is followed up a case by regular visits in straight line high definition scanning as claimed in claim 1, it is characterised in that: described
Reset the center position of high definition scanned straight lines according to registration result, specifically comprise the following steps that
If described First Line scanning laser optical fundus figure and described 3rd line scanning laser optical fundus figure registration are correct, return
Go back to computer acquisition interface, reset the second center position (x1+ Δ of described high definition scanned straight lines
xn,y1+Δyn)；
If described First Line scanning laser optical fundus figure and described 3rd line scanning laser optical fundus figure registration mistake, hands
Dynamic mobile described First Line scanning laser optical fundus figure, is offset the second displacement (Δ xp, Δ yp)；Return
Computer acquisition interface, resets the 3rd center position (x1+ Δ xp, the y1+ of described high definition scanned straight lines
Δyp)。
3. implementation method is followed up a case by regular visits in the straight line high definition scanning as according to any one of claim 1-2, and its feature exists
In, described registration is by by described First Line scanning laser optical fundus figure and described 3rd line scanning laser optical fundus
Same object of reference in figure carries out what coupling realized.
4. implementation method is followed up a case by regular visits in straight line high definition scanning as claimed in claim 3, it is characterised in that: described ginseng
Blood vessel or optic disc is included according to thing.
5. implementation method is followed up a case by regular visits in straight line high definition scanning as claimed in claim 1, it is characterised in that: if described
Dry second line scanning laser optical fundus figure, is in each the second line scanning laser optical fundus figure of Computer display
Collect after all having optical fundus figure.
6. implementation method is followed up a case by regular visits in straight line high definition scanning as claimed in claim 5, it is characterised in that: by described
Some second line scanning laser optical fundus figures mate one by one with described First Line scanning laser optical fundus figure respectively, its
Join result higher than threshold value.
7. implementation method is followed up a case by regular visits in the straight line high definition scanning as according to any one of claim 1-2, and its feature exists
In: described high definition scanned straight lines is with described first nodal point position (x1, y1) and described scanning angle (a1)
Scanning optical fundus, while obtaining some second line scanning laser optical fundus figures, is also obtained some width OCT figure
Picture.
8., such as claim 1, implementation method is followed up a case by regular visits in the straight line high definition scanning according to any one of 2,5,6, and it is special
Levy and be: trying to achieve of described some groups of offset displacements, be by by described some second line scanning laser optical fundus
Second pixel at figure center arrives the picture of first pixel at described First Line scanning figure center, laser optical fundus respectively
Element distance, is converted into what physical distance obtained.
9. a straight line high definition scanning follows up a case by regular visits to realize device, it is characterised in that including:
Follow up a case by regular visits to confirm module, be used for: confirm that storage high definition scanned straight lines in a computer completes to scan optical fundus
Time first nodal point position (x1, y1), scanning angle (a1) and First Line scanning laser optical fundus figure；
Statistical module, is used for: by include some second lines scanning laser optical fundus figures of eye fundus image respectively and
Described First Line scanning laser optical fundus figure coupling, obtains some groups of displacements, adds up from described some groups of displacements
Go out the first the highest displacement of the frequency of occurrences (Δ xn, Δ yn)；
Registration confirms module, for scanning the described First Line after offseting the first displacement (Δ xn, Δ yn)
The identical object of reference of laser optical fundus figure and the 3rd line scanning laser optical fundus figure carries out registration and confirms；Wherein, described
3rd line scanning laser optical fundus figure by described high definition scanned straight lines with described first nodal point position (x1, y1) and
Described scanning angle (a1) scanning optical fundus obtains；
OCT image acquisition module, is used for: when the first nodal point position (x1, y1) of described high definition scanned straight lines
The second center position (x1+ Δ xn, y1+ Δ yn) or the 3rd center position (x1+ is become through skew
Δ xp, y1+ Δ yp) after, high definition scanned straight lines scans human eye optical fundus with described scanning angle (a1), gathers
Some optical fundus OCT image；
Wherein, described 3rd center position (x1+ Δ xp, y1+ Δ yp) obtains in the following way:
If described First Line scanning laser optical fundus figure and described 3rd line scanning laser optical fundus figure registration mistake, manually move
Dynamic described First Line scanning laser optical fundus figure, is offset the second displacement (Δ xp, Δ yp)；Return and calculate
Machine acquisition interface, resets the 3rd center position (x1+ Δ xp, the y1+ Δ of described high definition scanned straight lines
yp)。
10. straight line high definition scanning as claimed in claim 9 follows up a case by regular visits to realize device, it is characterised in that: described
Registration result has a threshold value judged；When some second lines that each width collected all is comprised optical fundus figure
Scanning laser optical fundus figure, time respectively with described First Line scanning laser optical fundus figure coupling, each group obtained
Matching result is above described threshold value.
11. straight line high definition as claimed in claim 10 scannings follow up a case by regular visits to realize device, it is characterised in that: described
Each width all comprises some second line scanning laser optical fundus figures of optical fundus figure, is at described second line scanning laser
After having eye fundus image in the figure of optical fundus, computer continuous acquisition within the time period arranged obtains.
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