CN1049830C - Hot application for stopping cancer pain - Google Patents
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- CN1049830C CN1049830C CN95100343A CN95100343A CN1049830C CN 1049830 C CN1049830 C CN 1049830C CN 95100343 A CN95100343 A CN 95100343A CN 95100343 A CN95100343 A CN 95100343A CN 1049830 C CN1049830 C CN 1049830C
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Abstract
The present invention relates to a traditional Chinese medicine external application hot compress agent which belongs to the technical field of medicine. The present invention relates to a medicine bag prepared from wild ginger, dahurian angelica, borneol, raw nux vomica, aconitum Chinese paxton, kusnezoff monkshood, cinnamon, kaempferia galanga, olibanum, myrrh, sandalwood, dragon's blood, toad venom and raw araceae. A modern popular hot compress agent is used as a heat source to prompt effective components in the medicine bag to release slowly. The effective components are absorbed through skin and a shenque acupuncture point, and consequently the purposes of promoting qi circulation, relieving pain, softening and resolving hard mass and suppressing cancer pain are reached. The product has the advantages of convenient use, safety, effectiveness and no toxic or side effect and is an ideal treatment article for relieving the cancer pain.
Description
The invention belongs to medical technical field, especially is Chinese medicine external hot compress agent.
Cancer pain is the problem of a universality, and effectively pain management is one of four emphasis in World Health Organization's cancer unified plan.According to World Health Organization (WHO) statistics, the annual de novo cancer patient in the whole world has 7,000,000 approximately at present, and wherein 85% with in various degree pain.At present, the medicine for the treatment of cancer pain both at home and abroad mainly contains three major types:
(1) non-Opium class analgesic mainly is meant antipyretic-antalgic class medicine, and its representative drugs is an aspirin.Because this class medicine can be blocked the synthetic of prostaglandin, reduce body to local hemorrhages that stimulating factor produced such as wounds, tissue reactions such as swelling, thereby importing into of reducing that pain stimulates and make pain relief.But this type of medicine also all has suitable side effect, as GI irritation and bring out gastrointestinal ulceration etc.
(2) Opium class analgesic is meant the medicine that directly acts on spinal cord thalamus and cerebral cortex Opium receptoroid, and representative is codeine, morphine, dolantin.Because in varying degrees, they all can combine with the Opium receptoroid, can not cause that pain is excited and produce intensive analgesic activity at cerebral cortex thereby the pain of importing into is stimulated.Because this class medicine also has effects such as calmness, antitussive and anti-smooth muscle spasm simultaneously, these effects can cause some untoward reaction clinically, the particularly important is this type of medicine and also can cause the medicine drug resistance to reach the dependence that produces more or less on the body ﹠ mind, so the use of Opium class medicine all is strictly controlled in countries in the world.
(3) auxiliary analgesic drug product, relatively more commonly used is sedative (as stable), antuepileptic (phenytoin sodium) and neurotrophy medicine (vitamin B
1And B
12, bendazol etc.).This class medicine all can improve or improve the neurotrophy situation to a certain extent, thereby reduces importing into of pain stimulation.
The difficult control of cancer pain, the whole world has at least 3,500,000 cancer patients to suffer the torment of cancer pain every day at present, therefore, World Health Organization (WHO) pays much attention to the treatment of cancer pain, proposes to make the cancer patient painless in 2000, and three grades of pain relieving stepped cares of promotion cancer scheme, in the analgesic drug product selection course, grow from weak to strong, progressively upgrading, arrive strong Opium class medicine at last, as morphine, dolantin etc.Because the intractable and the persistency of ache in late cancer, increase progressively the clinical practice of Opium class drug dose continuously and constantly, can cause untoward reaction such as a series of physiological dependences and drug resistance unavoidably, drug dependence also can appear in a few patients, and analgesic drug product is used more and more, and therapeutic effect worse and worse.In addition doctor, patient to multiple factors such as this type of controlled delivery of pharmaceutical agents, the treatment of cancer pain is relatively stubborn problem of clinician all the time to the addicted psychology refusal of analgesic drug product and state's laws.
The objective of the invention is to for clinical provide a kind of easy to use, onset is quick, curative effect is reliable, have no side effect and a kind of heating power for the treatment of cancer pain of being easy to accept for the cancer patient applies.
A kind of heating power for the treatment of cancer pain provided by the present invention applies to be according to the traditional fomentation method of the traditional Chinese medical science and to press the theory of umbilicus method, on basis of experimental, utilize the fomentation effect of modern exothermic material, impel the slow release of effective ingredient, by the absorption of skin and SHENQUE acupoint, reach the purpose of promoting the circulation of QI to relieve pain, hard masses softening and resolving.
The present invention is achieved in that
Material medicine is made up of the Chinese medicine of following weight proportioning in the medicated bag: Herba Asari: the Radix Angelicae Dahuricae: Borneolum Syntheticum: Semen Strychni: Radix Aconiti: Radix Aconiti Kusnezoffii: Cortex Cinnamomi: Rhizoma Kaempferiae: Olibanum: Myrrha: Lignum Santali Albi: Sanguis Draxonis: Venenum Bufonis: Arisaema Cum Bile=0.6: 0.2 ∽ 0.4 of 1.2: 1.4 ∽ 0.6: 0.3 ∽ 0.7: 0.5 ∽ 0.9: 0.3 ∽ 0.7: 0.5 ∽ 0.9: 0.5 ∽ 0.9 ∽, 0.4 ∽ of 0.7: 0.3 ∽ of 0.9: 0.5 ∽ of 0.7: 0.3 ∽ of 2: 0.4 ∽ of 1: 0.8 ∽.
Also can be achieved in that
Can place a hot ironing bag in the medicated bag outside.
The preparation method that a kind of heating power for the treatment of cancer pain applies:
Radix Aconiti, Radix Aconiti Kusnezoffii, Olibanum, Myrrha are concocted the back pulverize the Borneolum Syntheticum mixing that the back adds porphyrize with the Semen Strychni that cleans, Herba Asari, Cortex Cinnamomi, Venenum Bufonis, the Radix Angelicae Dahuricae, Rhizoma Kaempferiae, Lignum Santali Albi, Sanguis Draxonis, Arisaema Cum Bile, sieve, pack in the bag, make even potted line on the sack, make medicine evenly and do not have a leakage.
The preparation method of hot ironing bag:
1 part of sawdust (60 order) adds 2.2 parts of abundant mixings of copper chloride-ammonium chloride solution, makes solution soak into sawdust, mixes 3 parts of ferrum ends while stirring, and is fierce and even, subpackage, and heat seal, airtight.
During use hot ironing bag is placed the outside of medicated bag, be placed in the outer bag that is connected with belt, be fixed on SHENQUE acupoint and get final product, also can separately medicated bag be put into the outer bag that is connected with belt and use.
The pharmacology pharmacodynamic research that a kind of heating power for the treatment of cancer pain applies:
1. mouse writhing method analgesic test
Get 60 of the white mice of body weight 20 ± 2 gram, be divided into three groups at random, 20 every group, the male and female dual-purpose.The experimental mice skin of abdomen is coated with to be used a kind of heating power for the treatment of cancer pain that normal saline is mixed with and applies 0.4g/ml, 0.5ml/10g; Positive controls is given dolantin lumbar injection, 0.1mg/10g; The blank group is coated with to skin of abdomen such as normal saline such as the capacity of grade and puts on the skin.Behind administration 20min, each organizes the respectively acetum 0.1ml/10g of lumbar injection 0.6% of mice, observe and record 20min in organize respectively that mice occurs turn round the body number of times, calculate its writhing response suppression ratio.Its writhing response suppression ratio is pressed the following formula statistics:
Experimental result shows that a kind of heating power for the treatment of cancer pain applies the writhing response that external can suppress mice significantly, P＜0.01, and its experimental result sees table 1 for details.
Table 1 the present invention counts writhing response number of times writhing response suppression ratio to the group laboratory animal that influences of mouse writhing reaction
(n) ((%) blank group 20 51.6 ± 18.7---the positive controls 20 12.7 ± 8.9** 75.4 experimental grouies 20 19.8 ± 10.5** 61.6 of X ± SD)
* and blank group are relatively, P＜0.012. mice hot-plate analgesic test regulation thermostat water temperature makes its plate temperature remain on 55 ± 0.5 ℃, and room temperature is controlled at 15-18 ℃, the female mice of body weight 20 ± 2g is put in the metal cylinder, measure the basic threshold of pain of each mice before the administration, select threshold of pain average, be divided into three groups at random 60 of the mices of 5S ∽ 30S, every group 20, the experimental group skin of abdomen is coated with to be used a kind of heating power for the treatment of cancer pain that normal saline is mixed with and applies 0.4g/ml, 0.5ml/10g; Positive controls is given dolantin lumbar injection, 0.1mg/10g; The blank group is given and is waited the capacity normal saline, and 0.5ml/10g, skin of abdomen are coated with and put on the skin.After administration 15,30,45min surveys the threshold of pain three times, gets its average, experimental result (seeing Table 2) shows: all the be significantly improved effect of the mice hot plate method threshold of pain of experimental group of the present invention and dolantin matched group, P＜0.01.The effect of dolantin seemingly is better than the present invention, and two groups relatively, P＞0.05, there was no significant difference.
The threshold of pain after the group basis threshold of pain administration of table 2 mice hot-plate analgesic test (N=60) (S, X ± SD)
(S, 15min 30min 45min blank group 18.1 ± 6.68 17.9 ± 5.97 18.2 ± 6.01 18.9 ± 6.88 positive controls 17.9 ± 5.99 41.8 ± 11.43 44.6 ± 14.18 42.8 ± 9.3 of X ± SD)
* * * * * experimental group 18.7 ± 6.07 43.1 ± 8.97 43.9 ± 12.01 41.2 ± 7.8
**Δ **Δ **Δ
* and blank group compare, P＜0.01
Δ and positive controls compare, P＞0.05
3. rat electrostimulation analgesic test
Get the rat of body weight 150 ± 10g, the male and female dual-purpose.Earlier by the basic threshold of pain of only measuring preceding each rat of administration, be coated with the skim conducting resinl at rat tails, carry out continued stimulus so that pharmacology physiology is many with instrument, frequency 8Hz, the wide 2ms of ripple, voltage is started from scratch, magnitude of voltage when sending first hoarseness after the electricity irritation of meter record rat and crying is measured 3 times, and getting its average is the preceding pain threshold of administration, select basic pain threshold at 10S with 40 of interior rats, be divided into two groups at random, 20 every group, the experimental group skin of abdomen is coated with a kind of heating power for the treatment of cancer pain that is mixed with normal saline and applies, 0.4g/ml, 0.5ml/10g; Positive controls is given dolantin lumbar injection, 0.1mg/10g.Survey after the administration 15,30 respectively, the threshold of pain during 45min, with before the administration relatively, experimental result sees Table 3.
The threshold of pain after the group basis threshold of pain administration of table 3 rat electrostimulation analgesic test (N=40) (S, X ± SD)
(S, the 15min 30min 45min positive controls 3.8 ± 1.2 23.8 ± 11.43 15.6 ± 9.18 7.8 ± 4.89 of X ± SD)
* * * * * experimental group 4.0 ± 1.6 19.74 ± 9.97 17.2 ± 11.01 14.5 ± 7.18
**Δ **Δ **ΔΔ
* and blank group compare, P＜0.01
Δ and positive controls compare, P＞0.05
Δ Δ and positive controls compare, P＜0.05
Experimental result shows: the present invention and dolantin all can obviously improve the rat threshold of pain, P＜0.01.
Confirmed that by mouse writhing method, hot plate method and three kinds of different pain models that cause of electrostimulation the present invention has stronger analgesic activity, compatibility and chemical constituent from this medicine, contained volatile oil has tangible central inhibitory action more in the medical materials such as Herba Asari, the Radix Angelicae Dahuricae, Borneolum Syntheticum, Cortex Cinnamomi, and contain alkaloids in the medicines such as Semen Strychni, system river, Radix Aconiti Kusnezoffii more, has stronger periphery analgesic activity, therefore, it is all effective that this medicine causes pain to electricity irritation, thermostimulation and chemical, and this and clinical observation result match.
Toxicologic study of the present invention:
1. skin acute toxicity test
8 of Cavia porcelluss are planted by the Britain of getting body weight and be 300 ± 20g, male and female are all used, be divided into two groups at random, before administration with depilatory slough belly wool reach 10% of body surface area ±, experimental group is at local this product 0.4g/ml 10g/kg that coats with the normal saline dilution of depilation, matched group such as is coated with at the normal saline of capacity, and with non-irritating gauze and immobilization with adhesive tape, behind the 24h, again by last method repeat administration, one week of successive administration, none death of each treated animal as a result, and any whole abnormal conditions all do not take place, the also no abnormality seen reaction of coating part, its experimental group dosage has been 25 times of clinical application amount.External safety of the present invention, reliable is described, body is not had obvious harmful effect.
2. skin irritation test
Getting body weight is the Britain kind Cavia porcellus of 300 ± 20g, male and female are all used, before administration with depilatory slough the left and right sides, back hair reach 10% of body surface area ±, select 20 of the Cavia porcelluss of skin zero damage after the depilation, be divided into four groups at random, its group experiment scheme sees Table 4: table 4 skin irritation group experiment scheme
Testing program
Grouping
Left side depilation district, depilation district right side normal skin irritant test: experimental group 0.4g/ml 10g/kg of the present invention self blank
Matched group NS 0.5ml/ is self blank damaged skin irritant test only: experimental group 0.4g/ml 10g/kg of the present invention self blank
Matched group NS 0.5ml/ is self blank only
The experimental group of normal skin irritant test is coated the present invention in depilation district left side, matched group such as is coated with at the normal saline of capacity in left side, depilation district, with non-irritating gauze and immobilization with adhesive tape.The experiment of damaged skin irritant test and contrast two groups and before administration, on depilation district left side skin, draw the scratch of " # " shape with No. 7 syringe needles respectively, diameter 2cm ±, so that slight oozing of blood degree of being to be arranged, experimental group is coated the present invention in left side, depilation district then, matched group such as is coated with at the normal saline of capacity in depilation district left side, and with non-irritating gauze and immobilization with adhesive tape, behind the administration 24h, remove the residual thing that tried with warm water, repeat administration again, so successive administration is after one week, in last removing is residual tried thing after, observe respectively and write down 1,24,48, the erythema of medicine-feeding part appearance in 72 hours, edema and phenomenon such as ooze out, and press table 5 evaluating skin stimulus intensity, its experiment the results are shown in Table 6.Table 5 skin irritation evaluation criterion
The average response value is estimated
0-0.9 have no stimulation
1-1.9 minimal irritation effect
〉=2 stimulations
The average response value that table 6 the present invention stimulates guinea pig skin
The grouping of number of animals average response value
(only) 1h 24h 48h 72h normal skin experimental group 5 0.80 0.40 0.00 0.00 damaged skin experimental grouies 5 1.60 1.00 0.40 0.00 normal skin matched groups 5 0.20 0.00 0.00 0.00 damaged skin matched groups 5 0.60 0.20 0.00 0.00
Experimental result shows, the present invention to the intact skin safe of Cavia porcellus, have no stimulation, there is the minimal irritation effect its average response value＜0.9 to the damaged skin of Cavia porcellus, fade away after observing 48h in its average response value＜1.9.
3. skin anaphylactic test
30 of Cavia porcelluss are planted by the Britain of getting body weight and be 300 ± 20g, are divided into three groups at random, and 10 every group, male and female are usefulness all, dosage regimen: (1) experimental group, and the depilation district is outer to be coated with 0.4g/ml of the present invention; (2) positive controls, the outer 2-4 chloronitrobenzene (1%) that is coated with in depilation district; (3) blank group, depilation are distinguished the normal saline of capacity such as being coated with outward.24h cuts the depilation district (the equal not damaged in depilation district) of 2 * 3cm respectively before the experiment in the guinea pig back left and right sides, with the percutaneous drug delivery sensitization contact, press above-mentioned dosage regimen respectively in left side depilation district's administration, continue that flush away is tried thing after 6 hours, be administered once every day, continuous 7 days, excited administration on the 21st day, be applied to depilation district, back part of animal right side respectively with will try thing with quadrat method, flush away was tried thing after 6 hours, observes at once, observed the skin allergy situation then again in 6,24,48,72 hours, by the scoring of anaphylaxis standard, its experiment the results are shown in Table 7.
Table 7 the present invention is to the skin allergy grouping number of animals average response value of Cavia porcellus
10 1.4 1.4 1.2 1.2 of the present invention groups 10 0.6 0.2 0.0 0.0 of (only) 6h 24h 48h 72h normal saline group 10 0.0 0.0 0.0 0.02-4 chloronitrobenzene groups
Experimental result shows: 6 hours skin of positive control drug 2.4-chloronitrobenzene treated animal self-excitation administration is subjected to the examination district to have obvious erythema to occur, and no edema sensitization rate is 100%.Experimental group animal self-excitation administration of the present invention after 6 hours skin be subjected to examination district that slightly show speckle of 6 animals is arranged, had 2 animals to still have slight erythema in 24 hours, disappear after 48 hours, its integral animal activity is also not unusual, this shows that the present invention does not have irritated effect.
Above toxicological experiment shows: the direct external avirulence of the present invention, there is not irritated effect, and normal skin is had no stimulation, damaged skin there is the minimal irritation effect, illustrate that the said preparation clinical practice is safe and reliable.
Clinical research of the present invention:
A kind of heating power for the treatment of cancer pain provided by the present invention applies and carries out clinical observation respectively through first Affiliated Hospital of the Henan Province college of traditional Chinese medicine, Henan Prov. Tumour Hospital, Chongqing City Sixth Man people hospital, observe cancer pain patient 580 examples altogether, adopt the stratified random design to divide into groups.Observation index: 1, core index: pain rating index (VRS), entry-into-force time (Min); 2, auxiliary characteristics: but the similar ratio of pain (VAS), quality of life score value (Konnfosky).The layering index is pain rating index (VRS), and its clinical observation grouping therapeutic regimen sees Table 8, and observed result sees Table 9 ~ table 13.
Table 8 clinical observation grouping therapeutic regimen pain rating index matched group experimental group (VRS) (simple western medicine) (drug combination) I degree antipyretic-antalgic class prescription with the weak Opium class medicine the present invention of the II degree of the present invention+strong Opium class of antipyretic-antalgic class medicine III degree medicine the present invention+weak Opium class medicine or
It is single with of the present invention group 47 13.83** matched group 48 27.11 that+strong Opium class medicine table 9 liang group pain relieving entry-into-force time (Min) statistical packet is observed the average pain relieving entry-into-force time of routine number (Min)
* and matched group compare, P＜0.01
But the similar ratio of pain (VAS) statistical packet before and after the table 10 liang group treatment is observed routine number observed result
(N) VAS (d) P value experimental group 295 29.24*＜0.01 matched group 285 22.88＜0.01
* compare pain rating indexs (VRS) statistics (N=295) characteristic of pain occurrence frequency (%) VRS (d) P value dull pain 252 (85.42) 14.29＜0.01 distending pains, 183 (62.03) 14.68＜0.01 shouting pains, 52 (17.63) 13.77＜0.01 hot cusalgia 57 (19.32) 9.43＜0.01 angina 8 (2.71) 11.32＜0.01 secret anguish 15 (5.08) 16.08＜0.01 lancinating pains 12 (4.07) 11.39＜0.01 tables 12 analgesic effect statistics of the present invention (%) before and after P＜0.05 table 11 the present invention treats with control group
Observe attached 149 16 74 51 8-141 of the First Academy of routine number CR MR PR NR total effective rate Henan College Of Traditional Chinese Medicine
(11.74) (49.66) (34.23) (5.37) (94.63) Henan Prov. Tumour Hospital 44 5 23 14 2 42
(11.36) Chongqing City, (52.27) (31.82) (4.55) (95.45) Sixth Man people hospital 102 15 48 28 11 91
(14.70) (47.06) (27.45) (10.78) (89.22) add up to 295 36 145 93 21 274
(12.20)(49.15)(31.52)?(7.12)(92.88)
Quality of life (Konnfosky) statistics before and after the table 13 liang group treatment
Observe routine number observed result grouping
(N) Konnfosky branch (X) P value experimental group 295 26.03*＜0.01 matched group 285 22.58＜0.01
* compare P＜0.05 with matched group
Observed result shows: of the present invention group total effective rate reaches 92.88%, and wherein, complete remission rate (CR) is 12.20%, and obviously remission rate (MR) is 49.15%, and part remission rate (PR) is 31.52%, and inefficiency (NR) is 7.12%.The average entry-into-force time of the present invention is 13.83Min, than the obvious shortening of matched group, and P＜0.01, clinical all have analgesic effect preferably to dull pain, distending pain, twinge, dull pain and angor etc., and P＜0.01 is inferior slightly to the effect of hot causalgia, P＜0.01.In addition, also can improve cancer patient's life quality behind a kind of heating power applying treatment for the treatment of cancer pain, P＜0.01 obviously is better than matched group, P＜0.05.Therefore, can think that the present invention truly has reliable pain palliation efficacy, and can improve ache in late cancer patient's life quality.
In this product side selected Herba Asari, Borneolum Syntheticum, the Radix Angelicae Dahuricae, Olibanum, Myrrha etc. be rich in that the fragrance of volatile oil capablely looses, the material of analgesia detumescences such as the product of pain relieving blood stasis dispelling and Semen Strychni, Radix Aconiti, Radix Aconiti Kusnezoffii, Venenum Bufonis, hard masses softening and resolving, and the fomentation agent of employing modern popular is a thermal source, impel the effective ingredient in the medicated bag slowly to discharge, seeing through skin and SHENQUE acupoint absorbs, thereby reach promoting the circulation of QI to relieve pain, hard masses softening and resolving, gram presses down the purpose of cancer pain then.
That this product prepares is simple, easy to use, onset quick, efficacy consolidation, have no side effect and do not have addiction, is a kind of treatment articles of ideal releasing cancer pain.
Embodiment 1
Material medicine and consumption:
Herba Asari 120g Radix Angelicae Dahuricae 120g Borneolum Syntheticum 200g Semen Strychni 60g Radix Aconiti 60g Radix Aconiti Kusnezoffii 60g Cortex Cinnamomi 80g Rhizoma Kaempferiae 80g Olibanum 60g Myrrha 60g Lignum Santali Albi 80g Sanguis Draxonis 80g Venenum Bufonis 60g Arisaema Cum Bile 40g
Its proportioning is: 1: 1: 1.67: 0.5: 0.5: 0.5: 0.67: 0.67: 0.5: 0.5: 0.67: 0.67: 0.5: 0.33.
Preparation method:
1. Radix Aconiti, Radix Aconiti Kusnezoffii, Olibanum, Myrrha are concocted the back and pulverize the Borneolum Syntheticum mixing that the back adds porphyrize with the Semen Strychni that cleans, Herba Asari, Cortex Cinnamomi, Venenum Bufonis, the Radix Angelicae Dahuricae, Rhizoma Kaempferiae, Lignum Santali Albi, Sanguis Draxonis, Arisaema Cum Bile, sieve, pack in the bag, every bag contains medicated powder 29g (the loading amount error is ± 5%), make even potted line on the sack, medicine is evenly distributed and does not have leakage.
2. get 2000g sawdust (60 order) and add the abundant mixing of 4400ml copper chloride monochlor(in)ate ammonium salt solution, make solution soak into sawdust, mix 6000g ferrum end while stirring, fierce and even, subpackage, every packed 250g (the loading amount error is ± 10%), heat seal, airtight.
3. when using hot ironing bag is rubbed heating, be placed on the medicated bag outside and medicated bag and put into the outer bag that is connected with belt together, be fixed on SHENQUE acupoint and get final product.Also can separately medicated bag be put into the outer bag that is connected with belt uses.
Embodiment 2
Material medicine and consumption:
Herba Asari 2000g Radix Angelicae Dahuricae 1600g Borneolum Syntheticum 3000g Semen Strychni 800g Radix Aconiti 800g Radix Aconiti Kusnezoffii 800g Cortex Cinnamomi 1000g Rhizoma Kaempferiae 1100g Olibanum 600g Myrrha 600g Lignum Santali Albi 1000g Sanguis Draxonis 1000g Venenum Bufonis 800g Arisaema Cum Bile 400g
Its proportioning is: 1: 0.8: 1.5: 0.4: 0.4: 0.4: 0.5: 0.55: 0.3: 0.3: 0.5: 0.5: 0.4: 0.2.
The preparation method of medicated bag and hot ironing bag and using method are with embodiment 1.
Embodiment 3
Material medicine and consumption:
Herba Asari 1000g Radix Angelicae Dahuricae 1200g Borneolum Syntheticum 2000g Semen Strychni 600g Radix Aconiti 700g Radix Aconiti Kusnezoffii 700g Cortex Cinnamomi 900g Rhizoma Kaempferiae 900g Olibanum 700g Myrrha 700g Lignum Santali Albi 900g Sanguis Draxonis 900g Venenum Bufonis 600g Arisaema Cum Bile 400g
Its proportioning is: 1: 1.2: 2: 0.6: 0.7: 0.7: 0.9: 0.9: 0.7: 0.7: 0.9: the preparation method of medicated bag and hot ironing bag and using method are with embodiment 1.
Claims (2)
1, a kind of heating power for the treatment of cancer pain applies, and it is characterized in that its interior material medicine of medicated bag is made up of the Chinese medicine of following weight proportioning: Herba Asari: the Radix Angelicae Dahuricae: Borneolum Syntheticum: Semen Strychni: Radix Aconiti: Radix Aconiti Kusnezoffii: Cortex Cinnamomi: Rhizoma Kaempferiae: Olibanum: Myrrha: Lignum Santali Albi: Sanguis Draxonis: Venenum Bufonis: Arisaema Cum Bile=0.6: 0.2 ∽ 0.4 of 1.2: 1.4 ∽ 0.6: 0.3 ∽ 0.7: 0.5 ∽ 0.9: 0.3 ∽ 0.7: 0.5 ∽ 0.9: 0.5 ∽ 0.9 ∽, 0.4 ∽ of 0.7: 0.3 ∽ of 0.9: 0.5 ∽ of 0.7: 0.3 ∽ of 2: 0.4 ∽ of 1: 0.8 ∽.
2. a kind of heating power for the treatment of cancer pain according to claim 1 applies, and it is characterized in that and can place a hot ironing bag in the medicated bag outside.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN95100343A CN1049830C (en) | 1995-01-13 | 1995-01-13 | Hot application for stopping cancer pain |
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|---|---|---|---|
| CN95100343A CN1049830C (en) | 1995-01-13 | 1995-01-13 | Hot application for stopping cancer pain |
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| CN1110598A CN1110598A (en) | 1995-10-25 |
| CN1049830C true CN1049830C (en) | 2000-03-01 |
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| CN95100343A Expired - Fee Related CN1049830C (en) | 1995-01-13 | 1995-01-13 | Hot application for stopping cancer pain |
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Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1078470C (en) * | 1997-03-20 | 2002-01-30 | 李宪爱 | Anti-cancer medicinal composition and its preparing method |
| CN102049091B (en) * | 2011-01-19 | 2012-07-04 | 张成海 | Special medicine bag for treating pain in waist and lower extremities by applying hot compress |
| CN105168723B (en) * | 2015-10-19 | 2020-01-17 | 中国中医科学院广安门医院 | A topical Chinese medicinal composition for treating cancer pain, and its preparation method |
| CN107349310B (en) * | 2017-05-17 | 2021-01-15 | 广州中医药大学 | Traditional Chinese medicine composition for treating cancer pain and application thereof |
| CN112773861A (en) * | 2021-02-09 | 2021-05-11 | 李华斌 | A plaster for treating pain and ulcer, and its preparation method |
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| CN1084849A (en) * | 1992-05-18 | 1994-04-06 | E·R·斯奎布父子公司 | Dual action inhibitors |
| CN1081104A (en) * | 1992-07-06 | 1994-01-26 | 杨世泽 | Analgesic plaster for cancer pain and compound method thereof |
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| Title |
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| 《中医药学报》(1) 1983.1.31 贝润浦，镇痛消肿膏治疗肿瘤临床观察 * |
| 《辽宁中医杂志》9(4) 1985.4.30 刘嘉湘等，蟾酥消肿膏治疗晚期恶性肿瘤疼痛187例疗效观察 * |
| 《辽宁中医杂志》9(4) 1985.4.30 刘嘉湘等，蟾酥消肿膏治疗晚期恶性肿瘤疼痛187例疗效观察;《中医药学报》(1) 1983.1.31 贝润浦，镇痛消肿膏治疗肿瘤临床观察 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1110598A (en) | 1995-10-25 |
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