CN104982671B - A kind of processing method of bambermycin filtrate - Google Patents
A kind of processing method of bambermycin filtrate Download PDFInfo
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- CN104982671B CN104982671B CN201510434619.8A CN201510434619A CN104982671B CN 104982671 B CN104982671 B CN 104982671B CN 201510434619 A CN201510434619 A CN 201510434619A CN 104982671 B CN104982671 B CN 104982671B
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- bambermycin
- filtrate
- precipitation
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- filtering residue
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Abstract
The invention discloses the processing method of a kind of bambermycin filtrate, belonging to animal feed additive preparing technical field, the technical scheme of employing is: add soluble metal salt solution, regulation system pH value in bambermycin filtrate, stand after stirring, form bambermycin precipitation；By bambermycin precipitation and bambermycin fermentation liquid filtering residue combination drying in the lump, it is used for preparing bambermycin pre-mixing agent.The method power consumption is low, and environmental protection is low for equipment requirements, and treatment effeciency is high.
Description
Technical field
The invention belongs to animal feed additive preparing technical field, be specifically related to the process side of a kind of bambermycin filtrate
Method.
Background technology
Bambermycin, also known as moenomycin (bambermycin), speckle primycin, for phosphoric acid polysaccharide antibiotic, is mainly used as feed additive to promote
Enter growth of animals or poultry.Bambermycin is the tunning of speckle Bai Shi streptomycete, and active component is present in mycelium and fermentation liquid.Fermentation
After end, fermentation liquor filters, and forms filtering residue and filtrate, and filtering residue is through airpillow-dry, and filtrate is spray-dried, finally by these two
Divide the additional calcium carbonate of desciccate or zeolite powder etc. to be compounded into the certain bambermycin pre-mixing agent of content to sell.It is said that in general, filter
Liquid amasss the 70-80% into bambermycin fermentating liquid volume, and filtrate Direct spraying energy consumption for drying is too high, directly influences product
Economy.
Chinese patent ZL 201010173871.5 (CN 101830942 B) uses and adds phosphoric acid in bambermycin fermentation liquid
Disodium hydrogen and calcium chloride solution, other impurity in Flocculated fermentation liquid, is filtered after the fermentation liquor filter press after flocculation
Liquid and filtering residue, filtrate first uses scraper plate thin film evaporation to concentrate, then is spray-dried and obtains pulverulent solids, and this pulverulent solids is
Mix with dried filtering residue afterwards, prepare and obtain bambermycin pre-mixing agent.
Filtrate is used double by Chinese patent ZL 201310011693.X (CN 103039718 B) the most before spray drying
Effect evaporation and concentration.
It is obvious that both technical schemes are all that filtrate concentrates (the former uses scraper plate thin before spray drying
Film evaporation and concentration, the latter uses double-effect evaporation to concentrate), decrease the volume of feed liquid, but feed liquid exists the most in fluid form, depend on
So cannot break away from spray drying drying efficiency relatively low, the shortcoming that energy consumption is big, and also feed liquid concentration process is also the workshop section of high energy consumption.
Summary of the invention
For the defect overcoming above-mentioned prior art to exist, it is an object of the invention to provide a kind of bambermycin filtrate
Processing method, the method is simple to operate, low for equipment requirements, energy-conserving and environment-protective.
The present invention is to be achieved through the following technical solutions:
The processing method of a kind of bambermycin filtrate disclosed by the invention, adds soluble metal in bambermycin filtrate
Saline solution, regulation system pH value, stand after stirring, form bambermycin precipitation；By bambermycin precipitation and bambermycin fermentation liquid
Filtering residue combination drying in the lump, is used for preparing bambermycin pre-mixing agent.
Preferably, the processing method of described bambermycin filtrate, comprise the following steps:
1) adding mass fraction in bambermycin filtrate is the soluble metal salt solution of 10%, and soluble metallic salt is molten
Liquid is 1:5～5:5 with the volume ratio of bambermycin filtrate, and regulation system pH value is 8.56～12.75, stands after stirring,
Obtain bambermycin precipitation, bambermycin precipitation is filtered, is precipitated filter cake；
2) by precipitated filter cakes and bambermycin fermentation liquid filtering residue combination drying in the lump, it is subsequently used for preparing bambermycin pre-mixing agent.
Soluble metallic salt is soluble calcium salt or solubility magnesium salt.
Described soluble calcium salt is calcium chloride.
Described solubility magnesium salt is magnesium chloride.
Described baking temperature is 100～120 DEG C.
Compared with prior art, the present invention has a following useful technique effect:
The processing method of bambermycin filtrate disclosed by the invention, uses the sedimentation method to process bambermycin filtrate, (bambermycin
Fermentation liquor is filtrated to get bambermycin filtrate and bambermycin fermentation liquid filtering residue), in bambermycin filtrate, add solubility gold
Belong to saline solution, then regulate through pH value, it is possible to the rate of deposition of bambermycin is effectively ensured.Meanwhile, the method is by prepared bambermycin
Precipitation and bambermycin fermentation liquid filtering residue combination drying in the lump process, and are used for preparing bambermycin pre-mixing agent.This method power consumption is low, green
Environmental protection, low for equipment requirements, treatment effeciency is high.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is described in further detail, described in be explanation of the invention and
It not to limit.
Bambermycin fermentation liquor is filtrated to get bambermycin filtrate and bambermycin fermentation liquid filtering residue, and Huang disclosed by the invention is mould
The processing method of element filtrate is as follows: add soluble metal salt solution in bambermycin filtrate, after regulation filtrate pH value,
Stand after stirring, form bambermycin precipitation；Bambermycin precipitation is processed with bambermycin fermentation liquid filtering residue combination drying in the lump,
For preparing bambermycin pre-mixing agent.
1, the pH impact on bambermycin rate of deposition
Measure 250mL bambermycin filtrate 2 parts, concentration 8230mg/L.Add the chlorination of 10% (mass percent) respectively
The each 250mL of calcium, magnesium chloride brine, in above-mentioned bambermycin filtrate, regulates pH with 1mol/L sodium hydroxide, forms precipitation, mistake
Filter.HPLC method measures bambermycin titer in filtrate, calculates the rate of deposition of bambermycin, the results are shown in Table 1.
Table 1.pH and the relation of bambermycin rate of deposition
2, the different metal addition impact on bambermycin rate of deposition
Measure 250mL bambermycin filtrate 5 parts, concentration 8230mg/L.Be separately added into 50ml (1:5), 100mL (2:5),
150mL (3:5), 200mL (4:5) and 250mL (5:5) 10% calcium chloride water, regulate pH with 1mol/L sodium hydroxide solution
To 12.75, form precipitation, filter.HPLC method measures the titer of bambermycin in filtrate, can calculate the rate of deposition of bambermycin.
PH 12.56 times, investigate the addition of magnesium chloride by same method and form the relation of precipitation, the results are shown in Table
2。
The impact on bambermycin rate of deposition of the table 2. different metal ion addition
Embodiment 1
Measure 500mL bambermycin filtrate, concentration 8039mg/L.Add 500mL 10% calcium chloride water, use 1mol/
L sodium hydroxide solution regulation pH to 12.75, forms precipitation, filters, and rate of deposition is 99.4%.
Bambermycin precipitation being filtered, precipitated filter cakes and bambermycin fermentation liquid filtering residue one are placed in 105 DEG C of oven dryings, industry
On can use the modes such as fluidized drying in hgher efficiency, airpillow-dry.
Embodiment 2
Measure 500mL bambermycin filtrate, concentration 8039mg/L.Add 500mL 10% calcium chloride water, use 1mol/
L sodium hydroxide solution regulation pH to 11.91, forms precipitation, filters, and rate of deposition is 80.4%.
Bambermycin precipitation being filtered, precipitated filter cakes and bambermycin fermentation liquid filtering residue one are placed in 100 DEG C of oven dryings.
Embodiment 3
Measure 500mL bambermycin filtrate, concentration 8039mg/L.Add 200mL 10% calcium chloride water, use 1mol/
L sodium hydroxide solution regulation pH to 12.75, forms precipitation, filters, and rate of deposition is 95.8%.
Bambermycin precipitation being filtered, precipitated filter cakes and bambermycin fermentation liquid filtering residue one are placed in 110 DEG C of oven dryings.
Embodiment 4
Measure 500mL bambermycin filtrate, concentration 8039mg/L.Add 100mL 10% calcium chloride water, use 1mol/
L sodium hydroxide solution regulation pH to 12.75, forms precipitation, filters, and rate of deposition is 88.5%.
Bambermycin precipitation being filtered, precipitated filter cakes and bambermycin fermentation liquid filtering residue one are placed in 105 DEG C of oven dryings.
Embodiment 5
Measure 500mL bambermycin filtrate, concentration 8039mg/L.Add 500mL 10% magnesium chloride brine, use 1mol/
L sodium hydroxide solution regulation pH to 8.56, forms precipitation, filters, and rate of deposition is 93.4%.
Bambermycin precipitation being filtered, precipitated filter cakes and bambermycin fermentation liquid filtering residue one are placed in 120 DEG C of oven dryings.
Embodiment 6
Measure 500mL bambermycin filtrate, concentration 8039mg/L.Add 500mL 10% magnesium chloride brine, use 1mol/
L sodium hydroxide solution regulation pH to 12.56, forms precipitation, filters, and rate of deposition is 95.2%.
Bambermycin precipitation being filtered, precipitated filter cakes and bambermycin fermentation liquid filtering residue one are placed in 105 DEG C of oven dryings.
Embodiment 7
Measure 500mL bambermycin filtrate, concentration 8039mg/L.Add 100mL 10% magnesium chloride brine, use 1mol/
L sodium hydroxide solution regulation pH to 12.56, forms precipitation, filters, and rate of deposition is 95.4%.
Bambermycin precipitation being filtered, precipitated filter cakes and bambermycin fermentation liquid filtering residue one are placed in 105 DEG C of oven dryings.
Embodiment 8
Measure 500mL bambermycin filtrate, concentration 8039mg/L.Add 300mL 10% magnesium chloride brine, use 1mol/
L sodium hydroxide solution regulation pH to 12.56, forms precipitation, filters, and rate of deposition is 97.4%.
Bambermycin precipitation being filtered, precipitated filter cakes and bambermycin fermentation liquid filtering residue one are placed in 100 DEG C of oven dryings.
Claims (3)
1. the processing method of a bambermycin filtrate, it is characterised in that comprise the following steps:
1) in bambermycin filtrate add mass fraction be the soluble metal salt solution of 10%, soluble metal salt solution with
The volume ratio of bambermycin filtrate is 1:5～5:5, and regulation system pH value is 8.56～12.75, stands, obtain after stirring
Bambermycin precipitates, and bambermycin precipitation is filtered, is precipitated filter cake；
Soluble metallic salt is soluble calcium salt or solubility magnesium salt；
2) precipitated filter cakes and bambermycin fermentation liquid filtering residue are mixed at 100～120 DEG C in the lump it are dried, be subsequently used for preparation yellow mould
Element pre-mixing agent.
The processing method of a kind of bambermycin filtrate the most according to claim 1, it is characterised in that described soluble calcium salt
For calcium chloride.
The processing method of a kind of bambermycin filtrate the most according to claim 1, it is characterised in that described solubility magnesium salt
For magnesium chloride.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510434619.8A CN104982671B (en) | 2015-07-22 | 2015-07-22 | A kind of processing method of bambermycin filtrate |
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| CN201510434619.8A CN104982671B (en) | 2015-07-22 | 2015-07-22 | A kind of processing method of bambermycin filtrate |
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| CN104982671B true CN104982671B (en) | 2016-10-12 |
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| CN108835063B (en) * | 2018-08-06 | 2021-02-26 | 陕西麦可罗生物科技有限公司 | Gorgon fish bait fermented by kasugamycin residues and preparation method |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1139589A (en) * | 1965-02-25 | 1969-01-08 | Hoechst Ag | Process for the manufacture of moenomycin by fermentation |
| CN1046939A (en) * | 1990-06-30 | 1990-11-14 | 湖南微生物制剂厂 | The production method of gibberellin water aqua |
| CN101830942A (en) * | 2010-05-13 | 2010-09-15 | 浙江钱江生物化学股份有限公司 | Post-treatment method of flavomycin |
| CN103039718A (en) * | 2013-01-14 | 2013-04-17 | 新疆天富阳光生物科技有限公司 | Manufacturing method of 8% flavomycin premixing agent |
-
2015
- 2015-07-22 CN CN201510434619.8A patent/CN104982671B/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1139589A (en) * | 1965-02-25 | 1969-01-08 | Hoechst Ag | Process for the manufacture of moenomycin by fermentation |
| CN1046939A (en) * | 1990-06-30 | 1990-11-14 | 湖南微生物制剂厂 | The production method of gibberellin water aqua |
| CN101830942A (en) * | 2010-05-13 | 2010-09-15 | 浙江钱江生物化学股份有限公司 | Post-treatment method of flavomycin |
| CN103039718A (en) * | 2013-01-14 | 2013-04-17 | 新疆天富阳光生物科技有限公司 | Manufacturing method of 8% flavomycin premixing agent |
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