CN104974186A - Production technology of optimal L-ascorbic acid-2- phosphate ester - Google Patents
Production technology of optimal L-ascorbic acid-2- phosphate ester Download PDFInfo
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- CN104974186A CN104974186A CN201510335500.5A CN201510335500A CN104974186A CN 104974186 A CN104974186 A CN 104974186A CN 201510335500 A CN201510335500 A CN 201510335500A CN 104974186 A CN104974186 A CN 104974186A
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Abstract
The invention relates to a production technology of optimal L-ascorbic acid-2- phosphate ester. The production technology comprises the steps of: adding purified water of which the temperature is lowered, and raw materials namely L-ascorbic acid to a reaction pot, and stirring the purified water and the L-ascorbic acid for 5-10 minutes; slowly and uniformly adding compounded calcium hydroxide suspension liquid, regulating PH to 4-5, and enabling the reaction temperature not to exceed 25 DEG C; adding sodium trimetaphosphate, in the process, controlling the PH not to exceed 6.0, and enabling the temperature to be 20-30 DEG C; after finishing addition, continuing adding the calcium hydroxide suspension liquid, and controlling the temperature to be 20-35 DEG C; regulating the PH to 10-12, when the PH value is not changed, adding anhydrous calcium chloride, and then discharging materials; and leaving the materials to stand for 4-5 hours, crushing the materials after standing, drying the crushed materials, and sieving the dried materials. The production technology disclosed by the invention increases the proportion of the L-ascorbic acid-2- phosphate ester in finished products, reduces the aberration of the finished products, and improves the appearance quality of the finished products.
Description
this is application number201210453404.7
divisional application.
Technical field
The present invention relates to production of vitamin C field, particularly relate to optimization L-AA-2-phosphoric acid ester production technique.
Background technology
In L-AA-2-phosphoric acid ester production process, the major cause affecting final finished quality is that reaction process controls, main finger various reaction time PH and temperature control, guarantee that lower vitamins C is most before oxidized and just participate in phosphotidic reaction, due to vitamins C under meta-alkalescence condition than slant acidity condition under more oxidizable, after comparison most literature data, and the production data when producing vitamin C calcium, by the test of production process, reaffirm the controling parameters of reaction whole process, final finished quality has obvious raising.
Summary of the invention
The object of this invention is to provide a kind of optimization L-AA-2-phosphoric acid ester production technique, to improve the ratio of L-AA-2-phosphoric acid ester in finished product, reduce finished product aberration, improve finished appearance quality.
The present invention is achieved in that optimization L-AA-2-phosphoric acid ester production technique, it is characterized in that: in retort, add cooling purified water and raw material L-AA, stirs 5 ~ 10min; Slowly evenly add the calcium hydroxide suspension configured, adjust PH to 4 ~ 5, temperature of reaction must not more than 25 DEG C; Add Trisodium trimetaphosphate, process control PH is no more than 6.0, and temperature is at 20 ~ 30 DEG C; Add after terminating and continue to add calcium hydroxide suspension, control temperature is at 20 ~ 35 DEG C; Adjustment PH to 10 ~ 12, treat that pH value is unchanged, then add blowing after Calcium Chloride Powder Anhydrous; Material is pulverized after leaving standstill 4 ~ 5h, dry, screening.
Invention increases the ratio of L-AA-2-phosphoric acid ester in finished product, decrease finished product aberration, improve finished appearance quality.
Embodiment
Optimize L-AA-2-phosphoric acid ester production technique, it is characterized in that: in retort, add cooling purified water and raw material L-AA, stir 5 ~ 10min; Slowly evenly add the calcium hydroxide suspension configured, adjust PH to 4 ~ 5, temperature of reaction must not more than 25 DEG C; Add Trisodium trimetaphosphate, process control PH is no more than 6.0, and temperature is at 20 ~ 30 DEG C; Add after terminating and continue to add calcium hydroxide suspension, control temperature is at 20 ~ 35 DEG C; Adjustment PH to 10 ~ 12, treat that pH value is unchanged, then add blowing after Calcium Chloride Powder Anhydrous; Material is pulverized after leaving standstill 4 ~ 5h, dry, screening.During concrete enforcement, the PH after adding calcium hydroxide is for the first time 4 ~ 5, then after adding Trisodium trimetaphosphate, system PH is no more than 6.0, guarantees that system is in slightly acidic environment like this.Add before Calcium Chloride Powder Anhydrous being adjusted to blowing, main purpose promotes that reaction guarantees that completely again material unduly solidifies, and improves the drying efficiency of micron dryer, reduce hyperthermia drying process.
The present invention is further illustrated below by embodiment, but not as limitation of the present invention.
Embodiment
Add temperature in retort not higher than 10 DEG C of purified water, add L-AA 250 kilograms, fully stir 10 minutes, slowly adding calcium hydroxide, is 4.3 to pH, and temperature is 20 DEG C, after adding 200 kilograms of Trisodium trimetaphosphates, PH is 5.6, and again add calcium hydroxide and react, control temperature is at 20 ~ 35 DEG C, adjustment PH to 10 ~ 12, maintain 80 minutes reaction times, treat that pH value is without considerable change, then add blowing after appropriate Calcium Chloride Powder Anhydrous; Material leave standstill after 4 ~ 5h with micron dryer carry out pulverizing, dry, screening.
The invention is not restricted to embodiment disclosed in these; the present invention is by the scope described by soverlay technique scheme; and the various distortion of right changes with equivalence; under the prerequisite not departing from technical solution of the present invention, any amendment that those skilled in the art made for the present invention easily realize or improvement all belong to the present invention's scope required for protection.
Claims (1)
1. optimize L-AA-2-phosphoric acid ester production technique, it is characterized in that: in retort, add cooling purified water and raw material L-AA, stir 5 ~ 10min; Slowly evenly add the calcium hydroxide suspension configured, adjust PH to 4 ~ 5, temperature of reaction must not more than 25 DEG C; Add Trisodium trimetaphosphate, process control PH is no more than 6.0, and temperature is at 20 ~ 30 DEG C; Add after terminating and continue to add calcium hydroxide suspension, control temperature is at 20 ~ 35 DEG C; Adjustment PH to 10 ~ 12, treat that pH value is unchanged, then add blowing after Calcium Chloride Powder Anhydrous; Material is pulverized after leaving standstill 4 ~ 5h, dry, screening.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012104534047A CN103113407A (en) | 2012-11-14 | 2012-11-14 | Production process for optimizing L-ascorbic acid-2-phosphate |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2012104534047A Division CN103113407A (en) | 2012-11-14 | 2012-11-14 | Production process for optimizing L-ascorbic acid-2-phosphate |
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| CN104974186A true CN104974186A (en) | 2015-10-14 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510335500.5A Pending CN104974186A (en) | 2012-11-14 | 2012-11-14 | Production technology of optimal L-ascorbic acid-2- phosphate ester |
| CN2012104534047A Pending CN103113407A (en) | 2012-11-14 | 2012-11-14 | Production process for optimizing L-ascorbic acid-2-phosphate |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2012104534047A Pending CN103113407A (en) | 2012-11-14 | 2012-11-14 | Production process for optimizing L-ascorbic acid-2-phosphate |
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Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105859779A (en) * | 2016-04-25 | 2016-08-17 | 江苏长运生物科技有限公司 | Production method of L-ascorbic acid-2-phosphate |
| CN108003191B (en) * | 2017-12-22 | 2019-12-17 | 宁夏启元药业有限公司 | Preparation method of vitamin C phosphate |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1491952A (en) * | 2003-09-27 | 2004-04-28 | 江苏江山制药有限公司 | Preparation of VC-2 phosphate ester salt |
| CN101665517A (en) * | 2008-09-03 | 2010-03-10 | 宜兴市江山生物科技有限公司 | Method for preparing L-ascorbic acid-2-phosphate |
| CN102276651A (en) * | 2011-06-28 | 2011-12-14 | 无锡市跨克微营养素有限公司 | Preparation method of L-ascorbic acid-2-sodium phosphate |
-
2012
- 2012-11-14 CN CN201510335500.5A patent/CN104974186A/en active Pending
- 2012-11-14 CN CN2012104534047A patent/CN103113407A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1491952A (en) * | 2003-09-27 | 2004-04-28 | 江苏江山制药有限公司 | Preparation of VC-2 phosphate ester salt |
| CN101665517A (en) * | 2008-09-03 | 2010-03-10 | 宜兴市江山生物科技有限公司 | Method for preparing L-ascorbic acid-2-phosphate |
| CN102276651A (en) * | 2011-06-28 | 2011-12-14 | 无锡市跨克微营养素有限公司 | Preparation method of L-ascorbic acid-2-sodium phosphate |
Non-Patent Citations (1)
| Title |
|---|
| 杜亚威，等: "维生素C磷酸酯钠的合成进展", 《精细与专用化学品》 * |
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| CN103113407A (en) | 2013-05-22 |
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Application publication date: 20151014 |
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