CN104971411B - Powder fog agent dosing device - Google Patents
Powder fog agent dosing device Download PDFInfo
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- CN104971411B CN104971411B CN201510373686.3A CN201510373686A CN104971411B CN 104971411 B CN104971411 B CN 104971411B CN 201510373686 A CN201510373686 A CN 201510373686A CN 104971411 B CN104971411 B CN 104971411B
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Abstract
A powder spray drug delivery device, which belongs to the field of inhalation type drug delivery instruments. The powder spray agent feeding device has good medicament powder adaptability and convenience for adjusting a mechanical structure parameter design vibration effect, so that the metering accuracy of the medicament powder dosage supplied by the medicament storage unit in each medicament feeding process of the whole powder spray agent feeding device is better ensured; meanwhile, the operation steps of the whole powder aerosol administration device are simplified, and better operation convenience is provided for the use of patients. When the powder spray drug delivery device is used, the rotary cover only needs to be manually rotated once along the first rotary direction and the second rotary direction, and a complete drug delivery-drug delivery process can be realized. Can be widely applied to the design and manufacturing fields of powder aerosol administration devices with various specifications.
Description
Technical Field
The application belongs to the field of instruments for inputting media into a human body, and particularly relates to an inhalation type drug administration instrument for delivering powder mist with specified dosage into the lung of a patient along with respiratory airflow through an oral cavity.
Background
In modern medical technology, the medicine can directly enter the lung and be absorbed into the blood by oral or nasal inhalation, so that the first pass effect of the liver is avoided.
Clinically, the medicine is mainly used for treating lung diseases such as asthma, chronic obstructive pneumonia, cystic fibrosis and the like. Due to the characteristics of thin alveolar epithelial cell wall, large surface area, low enzyme metabolic activity and the like, in recent years, a pulmonary administration mode gradually becomes a new way for non-invasive administration of more drugs (such as polypeptide and protein drugs and the like).
In the lung administration mode, the powder aerosol has a plurality of advantages compared with the aerosol, for example, the problem of cooperative coordination between a patient and the device in the use process of the aerosol can be avoided, and the propellant and the like are not needed, so that the powder aerosol is the lung inhalation preparation form with the best application prospect at present.
Powder aerosol refers to a formulation of micronized drug or drug in a capsule, vesicle or multi-dose depot form with a carrier, using a tailored powder aerosol administration device or inhalation device (or inhalation device, also known in the past as dry powder inhalation device or dry powder administration device), for active inhalation of the aerosolized drug by the patient to the lungs. The inhalation powder spray can enable medicine powder to enter a respiratory system by means of spontaneous breathing of a patient, and has the characteristics of convenience in carrying, low cost and high stability. In recent years, the application range of inhalation powder aerosols has been expanded from traditional therapeutic agents for local pulmonary diseases to systemic administration of polypeptide proteins, antibiotics, biopharmaceuticals and cardiovascular drugs. In particular, certain biological macromolecules can realize ideal bioavailability after being inhaled by medicine powder and being administrated to the lung.
The powder spray agent administration device is the core of powder spray agent development, the design quality directly influences the powder aerosol lung deposition efficiency.
For powder aerosol administration devices, there are currently generally two main categories: single and multiple doses, wherein multiple doses are generally divided into vesicular and depot forms.
Reservoir type inhalation drug delivery devices are generally provided with a powder container and corresponding metering members by which powdered medicament is sequentially and quantitatively dispensed from the powder container.
A significant problem with the micron-sized powders of the powder aerosol delivery device is that they have poor flowability, the powdered particles have a large surface energy, and the "agglomerated" state is easily formed, thus making the metering of each dose of the reservoir drug more difficult.
The inventor previously applied for, the Chinese patent of the application with the authority of 22 days of 04 months of 2015 and the authority of 102228725B discloses a dry powder administration device which comprises a runner component, a powder storage container and an administration metering component, wherein the upper part of a shell is provided with an inverted cone-shaped powder storage container; an annular manual rotating part is arranged on the periphery of the upper part of the shell; a rotary slideway is arranged on the outer surface of the upper part of the shell, and a sliding block is correspondingly arranged on the inner side of the annular manual rotary part; a first elastic member is provided between the annular manual rotation portion and the upper portion of the housing; an air inlet is arranged at one end of the rotary slideway; a flow passage part is arranged in the shell; a suction nozzle is arranged on the outer side of the shell, and an outer cover is arranged on the outer side of the suction nozzle; a medicine inlet is arranged at the horizontal part of the runner component; a dosing metering assembly is arranged below the inverted cone-shaped powder storage container; the runner component is sequentially connected with the air inlet, the dosing metering component and the suction nozzle through air paths. The powder metering assembly is dried before adding the powder, so that the powder dosage can be accurately metered, and overdose administration is avoided.
In the above technical scheme, the structure form of the rotary slide way is adopted to limit the rotation angle and the rotation direction of the manual rotary part so as to ensure the position relation between the inverted cone-shaped medicine powder storage container and the medicine feeding metering assembly below the inverted cone-shaped medicine powder storage container and the rotation direction of the quantitative medicine feeding disc in the medicine feeding metering assembly, ensure that the medicine feeding metering assembly can be dried and quantitatively fed before medicine feeding, and facilitate the medicine feeding groove with medicine feeding powder to align with the medicine feeding port of the runner component, complete the medicine feeding process and ensure that a patient inhales medicine powder to have preconditions.
However, in the practical use process, the structure form with the rotary slide rail is adopted, so that firstly, the structural complexity and the manufacturing procedure of the drug administration device are increased, secondly, due to the structural limitation of the rotary slide rail, a user needs to operate the rotary cover for 4 times to complete one drug administration and inhalation operation, the operation times and the steps are more, the use and the operation are inconvenient, and the smooth completion of the subsequent drug administration operation step can be influenced because the frequent rotation angle of the user is not in place.
On the premise of ensuring the rotation direction and the rotation angle of the quantitative dosing disc, the operation steps are simplified as much as possible, the convenience of operation is provided, and the technical scheme is also a problem to be solved in the implementation process.
Meanwhile, the medicine powder metering assembly structure in the technical scheme has more severe requirements on powder flowability, so that the metering accuracy of single medicine powder doses supplied by the whole powder spray agent dosing device can be better ensured, the good adaptability of the powder spray agent dosing device to medicine powder with a larger physical property range is improved, the adverse effect on the dosing accuracy caused by poor flowability of the filled medicine powder is overcome, and the structure of the medicine powder metering assembly is required to be improved again.
Disclosure of Invention
The application aims to solve the technical problem of providing a powder spray agent dosing device, which is characterized in that a vibrating gear is arranged below an agent dosing metering assembly to provide longitudinal vibration for the agent dosing metering assembly, and the powder spray agent dosing device has good agent powder adaptability and convenience in vibration effect adjustment of mechanical structure parameter design by adopting a 'single' or 'double' vibration mode for the medicine powder in a medicine powder storage container so as to better ensure the metering accuracy of the medicine powder dosage supplied by a medicine storage unit in each dosing process of the whole powder spray agent dosing device; meanwhile, the operation steps of the whole powder aerosol administration device are simplified, and better operation convenience is provided for the use of patients.
The technical scheme of the application is as follows: there is provided a powder aerosol administration device comprising a powder storage container and an administration metering assembly disposed in a housing of the administration device, a suction nozzle disposed outside the housing, a flow passage component is arranged in the shell and is sequentially connected with an air inlet, a dosing metering component and a suction nozzle through air passages; the method is characterized in that:
the drug delivery device shell consists of an upper cover, a shell and a lower shell which are coaxially sleeved in sequence, and a spiral cover is arranged at the lower end of the lower shell;
the runner component consists of a runner upper component and a runner lower component which are buckled into an integrated structure to form a complete runner gas circuit;
the dosing metering assembly at least comprises a rotary table, and a vibrating gear and a spring are sequentially arranged below the rotary table; the turntable, the vibration gear and the spring are coaxially sleeved;
a circle of vibrating teeth are arranged on the lower end surface of the turntable; a circle of lower vibrating teeth are arranged on the upper end surface of the vibrating gear; at least one pawl is arranged on the circumference of the turntable;
the upper end face of the rotary table is provided with a plurality of quantitative medicine tanks which are uniformly distributed along the circumference of the rotary table;
the powder storage container comprises an outer cartridge fixedly connected to the runner lower member;
the spiral cover, the spring, the vibration gear, the turntable and the outer cartridge case arranged on the runner lower member form a vibration medicine storage unit of the powder aerosol medicine feeding device;
the spiral cover is used for driving the drug delivery metering assembly and the vibration drug storage unit to work, and the drug delivery metering and vibration functions of the spiral cover are respectively realized, so that the whole drug delivery device has good drug type adaptability and convenience in adjusting the mechanical structure parameter design vibration effect, and the metering accuracy of the drug powder dosage supplied by the drug storage unit in each drug delivery process of the whole powder aerosol drug delivery device is improved;
when the rotary cover rotates to a first rotation angle along a first rotation direction, the rotary cover drives the vibration teeth, the rotary table is not driven by the vibration teeth, the vibration teeth and the rotary table move relatively, and meanwhile, the vibration teeth move up and down under the action of the springs, a vibration source is provided for the rotary table and the outer medicine cartridge, and the function of vibrating the medicine storage unit is achieved;
when the rotary cover rotates to a second rotation angle along a second rotation direction, the rotary cover drives the vibration teeth, the vibration teeth drive the rotary table to reversely rotate, and at the moment, a medicine groove filled with medicine powder rotates to a medicine delivery preparation position from the lower part of the medicine cylinder, so that one-time quantitative medicine supply is realized.
Further, an inner cartridge is also provided in the outer cartridge; the inner cartridge is nested in the outer cartridge, and the inner cartridge is freely movable in the outer cartridge; the spiral cover, the spring, the vibration gear, the turntable and the inner and outer medicine cartridges arranged on the runner lower member form a double vibration medicine storage unit of the powder aerosol medicine feeding device; the spiral cover is used for driving the drug administration metering assembly and the dual vibration drug storage unit to work, so that the drug administration metering and dual vibration functions are respectively realized; wherein the vibrating gear acts as a primary vibrating member and the inner cartridge acts as a secondary vibrating member.
When the rotary cover rotates along the first rotation direction, the vibration gear is driven to rotate, at the moment, the rotary table cannot rotate under the limit action of pawls arranged on the circumference of the rotary table, and relative motion is generated between the vibration gear and the rotary table; when the vibration gear and the turntable generate coaxial reverse relative motion, under the action of the elasticity of the spring, the upper vibration tooth and the lower vibration tooth generate mutual dislocation, so that the vibration gear continuously knocks the turntable to generate a vibration effect, and the vibration effect is transmitted to an outer cartridge on the runner lower member through the turntable to generate a first heavy vibration effect;
meanwhile, along with the vibration of the turntable, the knocking vibration of the vibration gear is synchronously transmitted to an inner cartridge in the outer cartridge to drive the inner cartridge to vibrate freely in the outer cartridge; the synchronous vibration of the inner cartridge case generates a second vibration effect, so that the medicine powder in the medicine powder storage container can flow into the quantitative medicine groove more uniformly.
Specifically, the inner cartridge is of a hollow tubular structure, the diameter of the lower end of the inner cartridge is smaller than that of the upper end of the inner cartridge, and the longitudinal section structure of the wall of the inner cartridge is of an inverted isosceles trapezoid structure with a large upper part and a small lower part.
Specifically, the first rotation direction of the rotary cover is opposite to the second rotation direction.
Further, the first rotation direction is a counterclockwise rotation direction from the top of the powder aerosol administration device in a plan view; the second rotation direction is clockwise from the top of the powder aerosol administration device in a plan view.
Specifically, the first rotation angle or the second rotation angle is greater than 0 ° and less than or equal to 360 °.
Further, the first rotation angle or the second rotation angle is 60 °.
Furthermore, an outer cover is arranged outside the suction nozzle and is used for sealing the suction nozzle and the outlet end of the runner gas circuit.
The application also provides an inhalation administration step of the powder aerosol administration device, wherein the powder storage container of the powder aerosol administration device comprises an outer cartridge fixedly connected on the runner lower member; the powder spray agent administration device is characterized in that the whole inhalation administration process is completed according to the following steps:
a1, removing the outer cover;
b1, manually rotating the rotary cover to a first rotation angle position along a first rotation direction;
c1, in the first rotation process of the rotary cover, the vibrating teeth and the rotary table generate relative motion, and vibrate the rotary table and the outer medicine cartridge to realize the vibration function of the medicine storage unit;
d1, manually rotating the rotary cover to a second rotation angle position along a second rotation direction;
e1, sucking medicinal powder by a patient through a suction nozzle;
f1, covering the outer cover, and ending the one-time medicine sucking use process.
Furthermore, the powder aerosol administration device completes the whole process of drug supply-drug administration according to the following sequence:
a11, removing the outer cover to remove the mechanical limit of preventing the mistaken rotation;
b11, manually rotating the rotary cover to a first rotation angle position along a first rotation direction, wherein a first medicine feeding groove of a turntable in the medicine feeding metering assembly receives medicine fed from the medicine powder storage container, so that one-time metering of medicine powder is realized;
c11, in the first rotation process of the rotary cover, the vibration teeth and the rotary table generate relative motion, and generate vibration to the rotary table and the outer medicine cartridge, so that the vibration function of the medicine storage unit is realized;
d11, manually rotating the rotary cover to a second rotation angle position along a second rotation direction; the first medicine feeding groove with medicine powder is aligned with the medicine inlet of the flow channel part, and the medicine feeding process is completed, so that the medicine powder inhaled by a patient has a precondition;
e11, the patient inhales the powder through the suction nozzle, the gas for carrying the powder enters the dry powder drug delivery device from the gas inlet, and the powder in the first drug delivery groove of the quantitative drug delivery disc is carried by the gas flow and is delivered into the lung of the patient through the suction nozzle along the flow channel part to the drug inlet, so that the drug delivery process is completed;
and F11, covering the outer cover, and ending the one-time medicine sucking use process.
The application also provides an inhalation administration step of the powder aerosol administration device, wherein the powder storage container of the powder aerosol administration device comprises an outer cartridge fixedly connected on the runner lower member and an inner cartridge positioned in the outer cartridge; the powder spray agent administration device is characterized in that the whole inhalation administration process is completed according to the following steps:
a2, removing the outer cover;
b2, manually rotating the rotary cover to a first rotation angle position along a first rotation direction;
c2, in the first rotation process of the rotary cover, the vibration teeth and the rotary table generate relative motion, and the rotary table and the inner and outer medicine cartridges are vibrated, so that the dual vibration function of the medicine storage unit is realized;
d2, manually rotating the rotary cover to a second rotation angle position along a second rotation direction;
e2, sucking the medicinal powder by the patient through a suction nozzle;
and F2, covering the outer cover, and ending the one-time medicine sucking use process.
Furthermore, the powder aerosol administration device completes the whole process of drug supply-drug administration according to the following sequence:
a21, removing the outer cover to remove the mechanical limit of preventing the mistaken rotation;
b21, manually rotating the rotary cover to a first rotation angle position along a first rotation direction, wherein a first medicine feeding groove of a turntable in the medicine feeding metering assembly receives medicine fed from the medicine powder storage container to realize quantitative medicine feeding;
c21, in the first rotation process of the rotary cover, the vibration teeth and the rotary table generate relative motion, and generate vibration to the rotary table and the inner and outer medicine cartridges, so as to realize the dual vibration function to the medicine storage unit;
d21, manually rotating the rotary cover to a second rotation angle position along a second rotation direction; the first medicine feeding groove with medicine powder is aligned with the medicine inlet of the flow channel part, and the medicine feeding process is completed, so that the medicine powder inhaled by a patient has a precondition;
e21, the patient inhales the powder through the suction nozzle, the gas for carrying the powder enters the dry powder drug delivery device from the gas inlet, and the powder in the first drug delivery groove of the quantitative drug delivery disc is carried by the gas flow and is delivered into the lung of the patient through the suction nozzle along the flow channel part to the drug inlet, so that the drug delivery process is completed;
f21, covering the outer cover, and ending the one-time medicine sucking use process.
In the inhalation administration step of the powder aerosol administration device, the vibration function or the dual vibration function can better ensure the metering accuracy of single-dose powder doses supplied by the whole powder aerosol administration device, increase the good adaptability of the powder aerosol administration device to a wider range of medicine powder types, and overcome the adverse effect of the filled medicine powder on the metering accuracy due to poor flowability.
Furthermore, when the powder spray drug delivery device is used, the rotating cover only needs to be manually rotated once along the first rotating direction and the second rotating direction, and the complete drug delivery-drug delivery process can be realized once.
The first rotation direction and the second rotation direction are opposite.
Compared with the prior art, the application has the advantages that:
1. by adopting the single vibration function of the outer cartridge or adopting the dual vibration modes of the inner and outer cartridges, the medicine powder in the medicine powder storage container can flow into the quantitative medicine tank more uniformly, the metering accuracy of the single medicine powder dosage supplied by the whole powder spray agent administration device can be ensured, the good adaptability of the powder spray agent administration device to a wider range of medicine powder types is improved, and the adverse effect of the filled medicine powder on the metering accuracy due to poor flowability is overcome;
2. on the premise of ensuring the drug supply-drug delivery effect, the operation steps are simplified, the drug supply-drug delivery process is complete once, and a user can realize the complete drug supply-drug delivery process only by manually rotating the rotary cover once in the anticlockwise direction and clockwise direction when in use;
3. the operation steps are simplified, the operation is more convenient and rapid, the use is convenient for users, the vibration intensity and the form are adjustable, and the range of applicable powder is wider.
Drawings
FIG. 1 is a schematic structural view of a powder aerosol administration device of the present application;
FIG. 2 is a cross-sectional view of the structure of the powder aerosol administration device of the present application;
FIG. 3 is a schematic top view of the gearing of the parts during the dose dispensing process of the present application;
FIG. 4 is a schematic view of the bottom view of the part drive during dose dispensing according to the present application;
FIG. 5 is a schematic view of the structure of a vibratory dosing unit of the present application;
fig. 6 to 9 are schematic views showing the operation steps of the powder aerosol administration device of the present application.
In the figure, 1 is a lower shell, 3 is a turntable, 3a is a quantitative medicine tank, 3b is an upper vibrating tooth, 3c is a pawl, 4 is a runner upper member, 5 is a runner lower member, 6 is a shell, 7 is a suction nozzle, 8 is a screw cap, 12 is a vibrating gear, 12a is a lower vibrating tooth, 13 is a spring, 14 is an inner medicine cartridge, 14a is an outer medicine cartridge, 15 is a medicine cartridge cover, 16 is an upper cover, and 17 is an outer cover.
Detailed Description
The application is further described below with reference to the accompanying drawings.
In fig. 1 to 5, the technical scheme of the application provides a powder aerosol administration device, which comprises a powder storage container and an administration metering assembly which are arranged in a shell of the administration device, wherein a suction nozzle is arranged at the outer side of the shell, a flow passage component is arranged in the shell, and the flow passage component is sequentially connected with an air inlet, the administration metering assembly and the suction nozzle through air passages; the application is characterized in that:
the drug delivery device shell consists of an upper cover 16, a shell 6 and a lower shell 1 which are coaxially sleeved in sequence, and a spiral cover 8 is arranged at the lower end of the lower shell;
the runner component consists of an upper runner component 4 and a lower runner component 5, and the upper runner component and the lower runner component are buckled into an integrated structure to form a complete runner gas path;
the dosing metering assembly at least comprises a rotary table 3, and a vibrating gear 12 and a spring 13 are sequentially arranged below the rotary table; the turntable, the vibration gear and the spring are coaxially sleeved;
a circle of vibrating teeth 3b are arranged on the lower end surface of the turntable; a circle of lower vibrating teeth 12a are arranged on the upper end surface of the vibrating gear; pawls 3c are provided on the circumference of the turntable;
the upper end face of the rotary table is provided with a plurality of quantitative medicine grooves 3a which are uniformly distributed along the circumference of the rotary table.
For ease of distinction and definition, the present solution will refer to the dosing groove just below the outer cartridge 14a as the first dosing groove (hereinafter).
The powder storage container at least comprises an outer cartridge 14a fixedly connected to the runner lower member.
As a variant of the solution, an inner cartridge 14 may be further provided in the outer cartridge 14a, and the powder storage container comprises an outer cartridge 14a fixedly connected to the runner lower member and an inner cartridge 14 located in the outer cartridge, the inner cartridge being nested in the outer cartridge, the inner cartridge being freely movable in the outer cartridge.
As can be seen from fig. 5, a cartridge cover 15 is provided at the upper end of the outer cartridge, said turntable, outer cartridge and cartridge cover forming a closed space in which the inner cartridge is free to move, either longitudinally along the longitudinal axis of the outer cartridge, transversely within the outer cartridge, a combination of longitudinally and transversely within the outer cartridge, or irregularly within the outer cartridge.
By the free movement of the inner cartridge in the outer cartridge, the powder of the powder aerosol medicament (or referred to as medicament powder) loaded in the outer cartridge is subjected to sufficient vibration.
The purpose of setting up interior cartridge case is through the change to interior cartridge case structural parameter, obtains better vibration effect.
An outer cover 17 is arranged outside the suction nozzle and is used for sealing the suction nozzle and the outlet end of the runner gas circuit.
The spiral cover, the spring, the vibration gear, the rotary table and the outer cartridge case arranged on the runner lower component form the vibration medicine storage unit of the powder aerosol medicine feeding device.
Or the spiral cover, the spring, the vibration gear, the turntable, the inner and outer medicine cartridges arranged on the runner lower member form a double vibration medicine storage unit of the powder aerosol medicine feeding device.
The powder spray dosing device comprises a runner lower component, a turntable, a dosing groove, an outer medicine cylinder and an inner medicine cylinder, and is characterized in that the dosing metering component of the powder spray dosing device is formed.
As can be seen from fig. 3 and 4, the tips of the upper and lower vibrating teeth are disposed opposite to each other to form a unidirectional ratchet wheel rotation kinematic pair.
Further, the upper vibrating teeth are annularly and uniformly distributed on the lower end surface of the turntable by taking the rotation center of the turntable as the circle center; the lower vibrating teeth are annularly and uniformly distributed on the upper end face of the vibrating gear by taking the rotation center of the vibrating gear as the circle center.
As can be seen from fig. 3 and 4, the upper and lower vibrating teeth are unidirectional bevel teeth.
The vibration gear serves as a main vibration member.
Further, the inner cartridge acts as a secondary vibrating member.
The spiral cover is used for driving the drug delivery metering assembly and the single or double vibration drug storage unit to work, and the drug delivery metering and vibration or double vibration functions of the spiral cover are respectively realized, so that the whole drug delivery device has good drug type adaptability and convenience in adjusting the mechanical structure parameter design vibration effect, and the metering accuracy of the drug powder dosage supplied by the drug storage unit in each drug delivery process of the whole powder aerosol drug delivery device is improved.
When the rotary cover rotates to a first rotation angle along a first rotation direction (in the technical scheme, the rotary cover overlooks downwards from the top of the powder aerosol administration device, so that whether the rotation direction of the rotary cover is anticlockwise rotation or clockwise rotation or the same applies to the description or judgment), the rotary cover drives the vibration teeth, at the moment, the rotary table is not driven by the vibration teeth, the vibration teeth and the rotary table generate relative motion, and meanwhile, the vibration teeth move up and down under the action of the springs, so as to provide vibration sources for the rotary table and the inner and outer medicine cartridges, and realize the function of vibrating or double vibrating along with the medicine storage unit;
when the rotary cover rotates to a second rotation angle along a second rotation direction, namely clockwise, the rotary cover drives the vibration teeth, the vibration teeth drive the rotary table to rotate along the second rotation direction, and at the moment, a medicine groove filled with medicine powder rotates to a preparation position from the lower part of the medicine box, so that one-time quantitative medicine supply is realized.
The first rotation angle or the second rotation angle is larger than 0 degrees and smaller than or equal to 360 degrees.
Further, the first rotation angle or the second rotation angle is 60 °.
The first rotation direction and the second rotation direction are opposite.
In the operation process of actual use, when the rotary cover 8 rotates to a first rotation angle along a first rotation direction (anticlockwise direction when seen from the top view of the powder aerosol administration device top), the vibration gear 12 is driven to rotate, at the moment, the rotary table does not rotate under the limit action of the pawl 3c arranged on the circumference of the rotary table, and relative motion (coaxial rotation) is generated between the vibration gear and the rotary table, and because the upper vibration teeth 3b and the lower vibration teeth 12a are respectively arranged on the combined end surfaces of the vibration gear and the rotary table, when the relative motion is generated between the vibration gear and the rotary table, under the elastic force of the spring 13, mutual dislocation is generated between the two groups of vibration teeth 3b and 12a, so that the vibration gear continuously knocks the rotary table, and a vibration effect is generated, and is transmitted to an outer cartridge arranged on a lower component of a runner through the rotary table, and a first heavy vibration effect is generated.
Meanwhile, along with the vibration of the outer cartridge, the knocking vibration of the vibration gear is synchronously transmitted to the inner cartridge in the outer cartridge to drive the inner cartridge to vibrate freely in the outer cartridge; the synchronous vibration of the inner cartridge case generates a second vibration effect, so that the medicine powder in the medicine powder storage container can flow into the quantitative medicine groove more uniformly, and the metering accuracy of the single medicine powder dosage supplied by the medicine powder storage container in each medicine administration process of the powder spray medicine administration device can be better ensured.
In this technical scheme, can adjust the intensity of medicine storage unit whole vibration effect through the quantity of changing vibration tooth, height and the elasticity of spring, improve the measurement accuracy of powder adding quantity.
The powder spray agent dosing device has good medicament type adaptability and convenience for design and adjustment of mechanical structure parameters.
As can be seen from fig. 5, the inner cartridge has a hollow tubular structure, the diameter of the lower end of the hollow tubular structure is smaller than that of the upper end of the inner cartridge, and the longitudinal cross-section of the wall of the inner cartridge has an inverted isosceles trapezoid structure with a large upper part and a small lower part.
In fig. 6 to 9, the technical solution of the present application further provides an inhalation administration step of the above-mentioned powder aerosol administration device, wherein the powder storage container of the powder aerosol administration device includes an outer cartridge fixedly connected to the runner lower member; the powder aerosol administration device completes the whole inhalation administration process according to the following steps:
a1, removing the outer cover;
b1, manually rotating the rotary cover to a first rotation angle position along a first rotation direction;
c1, in the first rotation process of the rotary cover, the vibrating teeth and the rotary table generate relative motion, and vibrate the rotary table and the outer medicine cartridge to realize the vibration function of the medicine storage unit;
d1, manually rotating the rotary cover to a second rotation angle position along a second rotation direction;
e1, sucking medicinal powder by a patient through a suction nozzle;
f1, covering the outer cover, and ending the one-time medicine sucking use process.
Furthermore, the powder aerosol administration device completes the whole process of drug supply-drug administration according to the following sequence:
a11, removing the outer cover to remove the mechanical limit of preventing the mistaken rotation;
b11, manually rotating the rotary cover to a first rotation angle position along a first rotation direction, wherein a first medicine feeding groove of a turntable in the medicine feeding metering assembly receives medicine fed from the medicine powder storage container, so that one-time metering of medicine powder is realized;
c11, in the first rotation process of the rotary cover, the vibration teeth and the rotary table generate relative motion, and generate vibration to the rotary table and the outer medicine cartridge, so that the vibration function of the medicine storage unit is realized;
d11, manually rotating the rotary cover to a second rotation angle position along a second rotation direction; the first medicine feeding groove with medicine powder is aligned with the medicine inlet of the flow channel part, and the medicine feeding process is completed, so that the medicine powder inhaled by a patient has a precondition;
compared with the prior technical scheme of the original dry powder drug administration device of the inventor, the powder aerosol drug administration device of the technical scheme is changed into 60 degrees of rotation every time from 120 degrees of rotation every time at the beginning; the positions of the medicine cartridge and the medicine inlet of the runner still differ by 120 degrees; therefore, when the powder aerosol administration device is operated, the first administration groove needs to be operated twice from the lower part of the medicine cartridge, and the medicine inlet of the runner can be aligned. Therefore, for the technical proposal, when the novel powder fog agent administration device is used for the first time, the operation needs to be carried out twice continuously to suck the medicine, and the second suction (or called second medicine) needs to be carried out once every time.
This characteristic of the powder aerosol administration device is determined by two factors: (1) The rotation angle, (2) the phase difference angle between the medicine inlet position of the medicine cartridge and the runner; (1) And (2) the relationship determines how many times the recess under the cartridge needs to be manipulated to reach the access port.
E11, the patient inhales the powder through the suction nozzle, the gas for carrying the powder enters the dry powder drug delivery device from the gas inlet, and the powder in the first drug delivery groove of the quantitative drug delivery disc is carried by the gas flow and is delivered into the lung of the patient through the suction nozzle along the flow channel part to the drug inlet, so that the drug delivery process is completed;
and F11, covering the outer cover, and ending the one-time medicine sucking use process.
The technical scheme of the application also provides an inhalation administration step of the powder aerosol administration device, wherein a powder storage container of the powder aerosol administration device comprises an outer cartridge fixedly connected on the runner lower member and an inner cartridge positioned in the outer cartridge; the powder spray agent administration device is characterized in that the whole inhalation administration process is completed according to the following steps:
a2, removing the outer cover;
b2, manually rotating the rotary cover to a first rotation angle position along a first rotation direction;
c2, in the first rotation process of the rotary cover, the vibration teeth and the rotary table generate relative motion, and the rotary table and the inner and outer medicine cartridges are vibrated, so that the dual vibration function of the medicine storage unit is realized;
d2, manually rotating the rotary cover to a second rotation angle position along a second rotation direction;
e2, sucking the medicinal powder by the patient through a suction nozzle;
and F2, covering the outer cover, and ending the one-time medicine sucking use process.
Furthermore, the powder aerosol administration device completes the whole process of drug supply-drug administration according to the following sequence:
a21, removing the outer cover to remove the mechanical limit of preventing the mistaken rotation;
b21, manually rotating the rotary cover to a first rotation angle position along a first rotation direction, wherein a first medicine feeding groove of a turntable in the medicine feeding metering assembly receives medicine fed from the medicine powder storage container to realize quantitative medicine feeding;
c21, in the first rotation process of the rotary cover, the vibration teeth and the rotary table generate relative motion, and generate vibration to the rotary table and the inner and outer medicine cartridges, so as to realize the dual vibration function to the medicine storage unit;
d21, manually rotating the rotary cover to a second rotation angle position along a second rotation direction; the first medicine feeding groove with medicine powder is aligned with the medicine inlet of the flow channel part, and the medicine feeding process is completed, so that the medicine powder inhaled by a patient has a precondition;
e21, the patient inhales the powder through the suction nozzle, the gas for carrying the powder enters the dry powder drug delivery device from the gas inlet, and the powder in the first drug delivery groove of the quantitative drug delivery disc is carried by the gas flow and is delivered into the lung of the patient through the suction nozzle along the flow channel part to the drug inlet, so that the drug delivery process is completed;
f21, covering the outer cover, and ending the one-time medicine sucking use process.
In the technical scheme, when the rotary cover rotates, the vibrating gear 12 is driven to rotate, and because the upper vibrating teeth 3b and the lower vibrating teeth 12a are respectively arranged on the combined end surfaces of the vibrating gear and the rotary table, when the vibrating gear and the rotary table generate relative motion (coaxial reverse rotation), under the elastic force of the spring 13, the two groups of vibrating teeth 3b and 12a generate mutual dislocation, so that the vibrating gear continuously knocks the rotary table, and a vibrating effect is generated on the rotary table and the inner and outer medicine cartridges, wherein the relative motion between the inner medicine cartridge and the outer medicine cartridge is vertical to the rotating direction of the rotary table;
when the powder spray agent dosing device of the technical scheme of the application is used, the complete dosing-dosing process can be realized only by manually rotating the rotary cover once in the anticlockwise direction and the clockwise direction.
Because the application adopts a single or double vibration mode for the medicine powder in the medicine powder storage container, the medicine feeding device has good medicine powder adaptability and the convenience of vibration effect adjustment of mechanical structure parameter design, so as to better ensure the metering accuracy of medicine powder dosage supplied by a medicine storage unit in each medicine feeding process of the whole powder aerosol medicine feeding device; meanwhile, the operation steps of the whole powder aerosol administration device are simplified, and better operation convenience is provided for the use of patients.
The application can be widely applied to the design and manufacturing fields of powder aerosol administration devices with various specifications.
Claims (7)
1. The powder aerosol administration device comprises a powder storage container and an administration metering assembly which are arranged in a shell of the administration device, wherein a suction nozzle is arranged at the outer side of the shell, a flow passage component is arranged in the shell, and the flow passage component is sequentially connected with an air inlet, the administration metering assembly and the suction nozzle through air passages; the method is characterized in that:
the drug delivery device shell consists of an upper cover, a shell and a lower shell which are coaxially sleeved in sequence, and a spiral cover is arranged at the lower end of the lower shell;
the runner component consists of a runner upper component and a runner lower component which are buckled into an integrated structure to form a complete runner gas circuit;
the dosing metering assembly at least comprises a rotary table, and a vibrating gear and a spring are sequentially arranged below the rotary table; the turntable, the vibration gear and the spring are coaxially sleeved;
a circle of vibrating teeth are arranged on the lower end surface of the turntable; a circle of lower vibrating teeth are arranged on the upper end surface of the vibrating gear; at least one pawl is arranged on the circumference of the turntable;
the upper end face of the rotary table is provided with a plurality of quantitative medicine tanks which are uniformly distributed along the circumference of the rotary table;
the powder storage container comprises an outer cartridge fixedly connected to the runner lower member;
the spiral cover, the spring, the vibration gear, the turntable and the outer cartridge case arranged on the runner lower member form a vibration medicine storage unit of the powder aerosol medicine feeding device;
the spiral cover is used for driving the drug delivery metering assembly and the vibration drug storage unit to work, and the drug delivery metering and vibration functions of the spiral cover are respectively realized, so that the whole drug delivery device has good drug type adaptability and convenience in adjusting the vibration effect of the design of mechanical structure parameters, and the metering accuracy of the drug powder dosage supplied by the drug storage unit in each drug delivery process of the whole powder aerosol drug delivery device is improved;
when the rotary cover rotates to a first rotation angle along a first rotation direction, the rotary cover drives the vibration teeth, the rotary table is not driven by the vibration teeth, the vibration teeth and the rotary table move relatively, and meanwhile, the vibration teeth move up and down under the action of the springs, a vibration source is provided for the rotary table and the outer medicine cartridge, and the function of vibrating the medicine storage unit is achieved;
when the rotary cover rotates to a second rotation angle along a second rotation direction, the rotary cover drives the vibration teeth, the vibration teeth drive the turntable to rotate, and at the moment, a medicine groove filled with medicine powder rotates to a medicine delivery preparation position from the lower part of the medicine cylinder, so that one-time quantitative medicine supply is realized;
an inner cartridge is also arranged in the outer cartridge; the inner cartridge is nested in the outer cartridge, and the inner cartridge is freely movable in the outer cartridge;
the spiral cover, the spring, the vibration gear, the turntable and the inner and outer medicine cartridges arranged on the runner lower member form a double vibration medicine storage unit of the powder aerosol medicine feeding device;
the spiral cover is used for driving the drug administration metering assembly and the dual vibration drug storage unit to work, so that the drug administration metering and dual vibration functions of the spiral cover are respectively realized;
wherein the vibrating gear serves as a main vibrating component, and the inner cartridge serves as a secondary vibrating component;
when the rotary cover rotates along the first rotation direction, the vibration gear is driven to rotate, at the moment, the rotary table cannot rotate under the limit action of pawls arranged on the circumference of the rotary table, and relative motion is generated between the vibration gear and the rotary table; when the vibration gear and the turntable generate coaxial reverse relative motion, under the action of the elasticity of the spring, the upper vibration tooth and the lower vibration tooth generate mutual dislocation, so that the vibration gear continuously knocks the turntable to generate a vibration effect, and the vibration effect is transmitted to an outer cartridge on the runner lower member through the turntable to generate a first heavy vibration effect;
meanwhile, along with the vibration of the turntable, the knocking vibration of the vibration gear is synchronously transmitted to an inner cartridge in the outer cartridge to drive the inner cartridge to vibrate freely in the outer cartridge; the synchronous vibration of the inner cartridge case generates a second vibration effect, so that the medicine powder in the medicine powder storage container can flow into the quantitative medicine groove more uniformly.
2. The powder aerosol administration device as set forth in claim 1, wherein said inner cartridge has a hollow tubular structure with a lower diameter smaller than an upper diameter of the inner cartridge, and said inner cartridge wall has a longitudinal cross-sectional structure of an inverted isosceles trapezoid structure with a large upper portion and a small lower portion.
3. The powder aerosol dispensing apparatus of claim 1, wherein the first rotational direction of the cap is opposite to the second rotational direction.
4. The powder aerosol dispensing apparatus of claim 1, wherein the first rotational direction is counter-clockwise from a top view of the powder aerosol dispensing apparatus; the second rotation direction is seen from the top of the powder spray agent administration device in a depression manner.
5. The powder aerosol dispensing apparatus of claim 1, wherein the first rotation angle or the second rotation angle is greater than 0 ° and less than or equal to 360 °.
6. The powder aerosol dispensing apparatus of claim 5, wherein the first rotation angle or the second rotation angle is 60 °.
7. The powder aerosol administration device as set forth in claim 1, wherein an outer cover is provided outside said mouthpiece for closing said mouthpiece and the outlet end of said flow path.
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| CN201510373686.3A CN104971411B (en) | 2015-06-30 | 2015-06-30 | Powder fog agent dosing device |
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| CN108014410A (en) * | 2016-10-31 | 2018-05-11 | 吉林化工学院 | Suck oscillatory type camphor therapeutic equipment |
| CN108057152B (en) * | 2017-12-29 | 2023-12-26 | 广州维力医疗器械股份有限公司 | Atomization tank with anti-reverse installation device |
| CN110064110A (en) * | 2019-05-29 | 2019-07-30 | 上海理工大学 | A kind of volume knob dry powder storage suction apparatus |
| CN110559528B (en) * | 2019-10-12 | 2024-06-07 | 万通(苏州)定量阀系统有限公司 | Aerosol drug feeder push button with counter |
| CN113842802A (en) * | 2021-11-01 | 2021-12-28 | 上海励江机电设备安装有限公司 | A coating dispersion machine for production of silica-based thermal insulation coating |
| CN114177443A (en) * | 2021-12-31 | 2022-03-15 | 上海臣邦医药科技股份有限公司 | Counter structure of powder aerosol administration device |
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| CN1810312A (en) * | 1997-03-14 | 2006-08-02 | 阿斯特拉公司 | Inhalation device |
| CN102218182A (en) * | 2011-06-13 | 2011-10-19 | 上海秀新臣邦医药科技有限公司 | Vibrating dosing device for dry power dosing device |
| CN103656811A (en) * | 2012-09-19 | 2014-03-26 | 上海理工大学 | Powder quantitative dosing device |
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| CN1810312A (en) * | 1997-03-14 | 2006-08-02 | 阿斯特拉公司 | Inhalation device |
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