CN204766907U - Powder spray is dosed two vibrations of device and is stored up prescriptions unit - Google Patents
Powder spray is dosed two vibrations of device and is stored up prescriptions unit Download PDFInfo
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- CN204766907U CN204766907U CN201520460093.6U CN201520460093U CN204766907U CN 204766907 U CN204766907 U CN 204766907U CN 201520460093 U CN201520460093 U CN 201520460093U CN 204766907 U CN204766907 U CN 204766907U
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Abstract
The utility model provides a powder spray is dosed two vibrations of device and is stored up prescriptions unit, belongs to the suction -type apparatus field of dosing. Spiral cover, spring, vibration gear, carousel and the setting outer cartridge case on the component under the runner, constitute the powder spray is dosed the vibration of device and is stored up prescription unit, its still be provided with in powder reservoir can synchronous free vibration the 2nd vibrating component - interior cartridge case, medicine powder to among the powder reservoir carries out dual vibration, in order to ensure the whole powder spray device measurement accuracy that the in -process stored up the prescription unit powder dosage that is supplied of dosing of dosing better at every turn, also the required mechanical structure design who goes on of reducible change because of of the loading medicine powder variety changes work load, the powder spray good adaptability of device to wider powder medicament kind of dosing has been increased. The powder spray that can extensively be applicable to various specifications the dose design of device, manufacturing field.
Description
Technical field
This utility model belongs to instrument field medium being inputted human body, particularly relates to a kind of inhalation-type drug administration apparatus for the powder spray of prescribed dose to be sent into patient lungs with respiratory air flow direct oral cavity.
Background technology
In modern medical service technology, adopt direct oral cavity or snuffing to enter to make medicine directly to enter pulmonary and absorbed into serum, avoid " head crosses " effect of liver.
Clinically, pulmonary administration is mainly used in the pulmonary disease such as treatment asthma, chronic obstructive pneumonia, cystic fibrosis.Because alveolar epithelial cells wall is thin, surface area is large, the active feature such as low of enzymes metabolism, in recent years, pulmonary administration mode becomes the new way of more drug (as polypeptide and protein medicaments etc.) noninvasive administration gradually.
In pulmonary administration mode, powder spray has many advantages compared with aerosol, if avoid the problem of aerosol in use patient and device coordinated, without the need to using propellant etc., is therefore have the lung of application prospect to suck dosage form at present most.
Powder spray mean micronized medicine or with carrier with capsule, vesicle or multiple dose reservoir type, special powder spray doser or suction apparatus is adopted (or to be called suction type medicator, past is also referred to as powder inhaler or dry powder drug administration device), initiatively suck the dosage form of atomization medicine to pulmonary by patient.Inhalation powder spray relies on the autonomous respiration of patient to make drug powder enter respiratory system, and have and be easy to carry, cost is low, the feature that stability is strong.In recent years, the range of application of inhalation powder spray has been extended to the Formulations for systemic administration of polypeptide protein class, antibiotic, bio-pharmaceutical and medicine for cardiovascular system from traditional lung local disease curative.Particularly some biomacromolecules can realize comparatively ideal bioavailability after drug powder suction-pulmonary administration.
Powder spray doser is the core of powder spray exploitation, and the quality of its design directly has influence on the height of powder spray lung deposition efficiencies.
For powder spray doser, be generally divided into two large classes at present: single dose and many meterings, wherein multiple dose is generally divided into again vesicle type and depot.
Depot suction type medicator is all provided with a dust container and corresponding metering element usually, successively separates efflorescence medicament quantitatively by metering element from dust container.
It is that poor fluidity, powdery granule has larger surface energy, easily forms " reunions " state, thus causes larger difficulty to the metering of the every dose of depot medicine that the micron powder of powder spray doser exists a larger problem.
The applicant applies for before this, authorized announcement date is on February 18th, 2015, Authorization Notice No. is in the Chinese invention patent of CN102218182B, disclose one " vibrating dosing device of dry powder drug administration device ", it comprises housing, medicated powder storage capsule, administration gauge assembly and flow path features, and flow path features connects air inlet, administration gauge assembly and suction nozzle successively; Its inventive point is that it is provided with the medicated powder storage capsule of an inverted cone shape at housing upper, the administration gauge assembly comprising central rotating shaft and dosed administration dish is set in the below of inverted cone shape medicated powder storage capsule, the vibration tooth of one projection is set in the outlet of inverted cone shape medicated powder storage capsule, on vertical height position corresponding with vibration tooth on central rotating shaft, a circle raised tooth is set; Vibration tooth coordinates with raised tooth, forms one and inverted cone shape medicated powder storage capsule can be made to export vibrative vibration component.Because it adopts the mode of vibration of vibration tooth-raised tooth, in the outlet of powder bank (i.e. inverted cone shape medicated powder storage capsule), vibration administration unit is set, the size of vibration force or Oscillation Amplitude and elastomeric element have nothing to do, not by the impact of medicated powder storage capacity change, achieving can the function of accurate-metering medicated powder dosage, and avoids the danger of super metering administration.
Inverted cone shape medicated powder storage capsule in technique scheme, its design parameter (back taper angle) is once determine, then can only adapt to the drug powder of a certain yield limit, for the drug powder with more severe the liquidity scale parameter, cannot adapt to well.When the physical performance index (typically referring to the liquidity scale of drug powder) of loaded drug powder changes, can only by redesigning the Machine Design parameter of inverted cone shape medicated powder storage capsule and vibration administration unit, in each administration process of guarantee supply the metering accuracy of medicated powder dosage (under the single dose be namely commonly called as dose), therefore the powder spray doser designing and produce, for a certain concrete drug powder, can only not there is good medicament kind adaptability and the convenience of mechanical configuration parameter design modifying.
Utility model content
Technical problem to be solved in the utility model is to provide a kind of two vibration medicine storage unit of powder spray doser, it is while carrying out clashing into vibration to the medicated powder storage capsule of medicine storage unit, also being provided with in medicated powder storage capsule can the second vibrating mass-interior cartridge case of synchronously free vibration, dual-vibration is carried out to the drug powder in medicated powder storage capsule, with guarantee better medicine storage unit in each administration process of whole powder spray doser the metering accuracy of confession medicated powder dosage, also can reduce the Design of Mechanical Structure carried out needed for the change because of loaded drug powder kind and change workload, add the adaptability of powder spray doser to wider powder medicine kind.
The technical solution of the utility model is: the two vibration medicine storage unit providing a kind of powder spray doser, described powder spray doser comprises and is arranged on medicated powder storage capsule in doser housing and administration gauge assembly, suction nozzle is had in the arranged outside of housing, the inside of housing is provided with flow path features, and flow path features successively gas circuit connects air inlet, administration gauge assembly and suction nozzle; It is characterized in that:
Described housing is made up of upper cover, middle shell and lower house, and on described lower house, suit arranges a spiral cover;
Described spiral cover sets gradually spring, a vibration gear and a rotating disk;
Described spring housing dress is arranged on the central rotating shaft of described vibration gear;
On the upper surface of described vibration gear, be provided with the lower vibration tooth of a circle projection;
On the lower surface of described rotating disk, be provided with the upper vibration tooth of a circle projection; Circumferentially ratchet is provided with at described rotating disk;
The upper surface of described rotating disk is provided with multiple quantitative medicine groove, described multiple quantitative medicine groove with the central shaft of rotating disk for the center of circle, along the circumference uniform distribution of rotating disk;
Above described rotating disk, arrange runner lower member and runner upper member, described runner lower member and runner upper member fasten and fix as one, and form a complete runner gas circuit;
Described runner lower member arranges a medicated powder storage capsule;
Described medicated powder storage capsule at least comprises the outer cartridge case be fixed on described runner lower member and the cartridge case being arranged in outer cartridge case, and described interior cartridge case is nested in described outer cartridge case, and described interior cartridge case can move freely in described outer cartridge case;
Described vibration gear serves as principal oscillation parts, and described interior cartridge case serves as from vibrating mass;
Described spiral cover, spring, vibration gear, rotating disk and the inside and outside cartridge case be arranged on described runner lower member, form two vibration medicine storage unit of described powder spray doser;
The lower end of described outer cartridge case is provided with the lower open end running through described runner lower member, and described lower open end is positioned at multiple quantitative medicine groove distribution place, described rotating disk upper surface circumferentially.
Further, described two vibration medicine storage unit, in medicated powder storage capsule, are also provided with and can serve as from vibrating mass the interior cartridge case of synchronously free vibration.
Concrete, described spring, vibration gear and rotating disk are coaxially set.
Concrete, the crown of described upper and lower vibration tooth is arranged in opposite directions, forms a single direction ratchet rotational motion secondary.
Concrete, the first described direction of rotation from the overhead view of powder spray doser for being rotated counterclockwise direction; The second described direction of rotation is dextrorotation veer from the overhead view of powder spray doser.
Further, described upper vibration tooth, with the center of rotation of described rotating disk for the center of circle, ring-type is distributed on the lower surface of described rotating disk; Described lower vibration tooth, with the center of rotation of described vibration gear for the center of circle, ring-type is distributed on the upper surface of described vibration gear.
Further, described upper and lower vibration tooth is unidirectional inclined-plane tooth.
It arranges a base cover in the upper end of described outer cartridge case, and described rotating disk, outer cartridge case and base cover form an enclosed space, and in described enclosed space, described interior cartridge case can freely move.
Described quantitative medicine groove is the blind hole structure being arranged on rotating disk upper surface.
Further, the lower ending opening diameter of described outer cartridge case is less than the opening diameter of outer cartridge case upper end, the longitudinal profile structure of described outer cartridge interior cavity, is a up big and down small inversion isosceles trapezoidal structure.
Further, described interior cartridge case is the tubular structure of a hollow, and its lower end diameter, is less than the upper end diameter of interior cartridge case, the longitudinal profile structure of described interior cartridge wall, is a up big and down small inversion isosceles trapezoidal structure.
Compared with the prior art, the utility model has the advantages that:
1. adopt master and slave vibrating mass structure, produce dual-vibration effect, make the drug powder being arranged in medicated powder storage capsule, can flow into more uniformly in described quantitative medicine groove, can guarantee better described powder spray doser at each administration process Chinese medicine powder storage capsule supply the metering accuracy of single-dose powder amount;
2. in the below of medicated powder storage capsule medicated powder outlet, adopt vibration gear, by rotating disk, overall percussive vibration is carried out to runner lower member, better vibrating effect can be produced, and the requirement that can reduce vibration component material, intensity, be conducive to the design of product, manufacture and reduction manufacturing cost;
3. by the adjustment of the elastic force to spring, the tooth depth vibrating tooth, the number of teeth and interior cartridge case mechanical configuration parameter, the power to the vibration of doser Chinese medicine powder storage capsule can be changed easily, can according to the liquidity scale of institute's drug loading powder, carry out the adjustment of vibration component structure easily, thus the metering accuracy of powder spray doser can be guaranteed better, make doser have convenience and the drug powder kind adaptability of good vibrating effect adjustment.
Accompanying drawing explanation
Fig. 1 is the decomposition texture schematic diagram of this utility model powder spray doser correlation unit;
Fig. 2 is the decomposition texture upward view of this utility model powder spray doser correlation unit;
Fig. 3 is the sectional structure schematic diagram of inside and outside cartridge case, upper and lower runner and rotating disk in this utility model two vibration medicine storage unit;
Fig. 4 is the package assembly schematic diagram of this utility model powder spray doser correlation unit.
In figure, 1 is lower house, and 3 is rotating disk, and 3a is quantitative medicine groove, 3b is upper vibration tooth, and 3c is ratchet, and 4 is runner upper member, 5 is runner lower member, and 6 is middle shell, and 8 is spiral cover, 12 is vibration gear, and 12a is lower vibration tooth, and 13 is spring, 14 is interior cartridge case, 14a is outer cartridge case, and 15 is base cover, and 16 is upper cover.
Detailed description of the invention
Below in conjunction with drawings and Examples, this utility model is described further.
Known shown in composition graphs 1 to Fig. 4, the technical solution of the utility model, provide a kind of two vibration medicine storage unit of powder spray doser, described powder spray doser comprises and is arranged on medicated powder storage capsule in doser housing and administration gauge assembly, suction nozzle is had in the arranged outside of housing, the inside of housing is provided with flow path features, and flow path features successively gas circuit connects air inlet, administration gauge assembly and suction nozzle; Its inventive point is:
Described housing is made up of upper cover 16, middle shell 6 and lower house 1, and on lower house, suit arranges a spiral cover 8 (shown in Fig. 4).
Spiral cover sets gradually spring 13, vibration gear 12 and a rotating disk 3, and spring housing dress is arranged on (shown in Fig. 1,2) on the central rotating shaft of vibration gear.
On the upper surface of vibration gear, be provided with the lower vibration tooth 12a (shown in Fig. 1) of a circle projection; On the lower surface of rotating disk, be provided with the upper vibration tooth 3b (shown in Fig. 2) of a circle projection.
Ratchet position limiting structure 3c (shown in Fig. 2) is circumferentially provided with at rotating disk.
The upper surface of rotating disk is provided with multiple quantitative medicine groove 3a, described multiple quantitative medicine groove with the central shaft of rotating disk for the center of circle, along the circumference uniform distribution of rotating disk.
Above rotating disk, be provided with runner lower member 5 and runner upper member 4, described runner lower member and runner upper member fasten and fix as one, and form a complete runner gas circuit.
Runner lower member is provided with a medicated powder storage capsule; Described medicated powder storage capsule at least comprises the outer cartridge case 14a be fixed on described runner lower member and the cartridge case 14 being arranged in outer cartridge case, in it, cartridge case is nested in described outer cartridge case, and interior cartridge case can move freely (shown in Fig. 3) in cartridge case outside.
Described spiral cover, spring, vibration gear, rotating disk and the inside and outside cartridge case be arranged on described runner lower member, form two vibration medicine storage unit of described powder spray doser.Described vibration gear serves as principal oscillation parts, and described interior cartridge case serves as from vibrating mass.
The lower end of described outer cartridge case is provided with the lower open end running through described runner lower member, and described lower open end is positioned at multiple quantitative medicine groove distribution place, described rotating disk upper surface circumferentially.
Described runner lower member, rotating disk, quantitatively medicine groove, outer cartridge case and interior cartridge case, form the administration gauge assembly of described powder spray doser.
In the operating process that reality uses, when spiral cover 8 rotates (being seen as counterclockwise from powder spray doser depression angle) to certain angle (as 60 °) along the first direction of rotation, drive vibration gear 12 is rotated, now rotating disk can not rotate under the position-limiting action of its three circumferentially set ratchet 3c, relative motion (coaxially rotating backward) is produced between vibration gear and rotating disk, due at vibration gear and rotating disk in conjunction with on end face, be respectively arranged with, lower vibration tooth 3b and 12a, when then producing relative motion (coaxially rotating backward) between vibration gear and rotating disk, under the elastic force effect of spring 13, the mutual changing of the relative positions is produced between two groups of vibration tooth 3b and 12a, vibration gear is caused constantly to knock rotating disk, produce vibrating effect, this vibrating effect conducts on the outer cartridge case that is positioned on runner lower member by rotating disk, produce the first heavy vibrating effect, meanwhile, the percussion vibration of vibration gear synchronous can be passed to and be arranged on outer cartridge case cartridge case by rotating disk, and in driving, free vibration is done in the inside of cartridge case cartridge case outside, the synchronous vibration of described interior cartridge case, produce the second heavy vibrating effect, make the drug powder being arranged in medicated powder storage capsule, can flow in quantitative medicine groove more uniformly and stably, can guarantee that powder spray doser is in each administration process better, medicated powder storage capsule supply the metering accuracy of single-dose powder amount.
By changing the elastic force of the quantity, height and the spring that vibrate tooth, the power of medicine storage unit body vibration effect can be adjusted, improves the metering accuracy of medicated powder powder chemical feeding quantity.
Also can according to the liquidity scale of medicated powder powder, by regulating the size of the base angle of inside and outside cartridge case and interior cartridge case quality, regulate and guarantee the prescribe medicine metering accuracy of single-dose powder amount further, make powder spray doser have good drug powder kind adaptability and the convenience of mechanical configuration parameter design modifying.
When described spiral cover rotates to the process of certain angle (as 60 °) along the second direction of rotation (being seen as from powder spray doser depression angle clockwise), spiral cover drives vibration tooth, vibration cingulum moves turntable rotation, now a medicine groove installing medicated powder is from rotating below cartridge case to preparation delivering drugs position, realizes once " quantitatively " for medicine.
Clearly, the first described direction of rotation is contrary with the second direction of rotation.
In the technical solution of the utility model, described two vibration medicine storage unit, principal oscillation parts are being served as by vibration gear, while described medicated powder storage capsule is vibrated, in medicated powder storage capsule, also be provided with and can the interior cartridge case of synchronously free vibration serve as from vibrating mass, dual-vibration is carried out to the drug powder in medicated powder storage capsule, with guarantee better whole powder spray doser the metering accuracy of confession single-dose powder amount, add the adaptability of powder spray doser to various drug powder kind, overcome the adverse effect that powder brings administration metering accuracy due to poor fluidity.
Shown in Fig. 3, the upper end of cartridge case arranges a base cover 15 outside, described rotating disk, outer cartridge case and base cover form an enclosed space, in described enclosed space, interior cartridge case can move freely, and described moves freely, can be interior cartridge case vertically moving along outer cartridge case longitudinal axis, also in the transverse shifting of cartridge case outside in cartridge case, the compound of also described interior cartridge case vertical and horizontal movement in cartridge case outside, or the irregular movement of interior cartridge case outside in cartridge case.
By moving freely in interior cartridge case outside cartridge case, to the powder spray drug powder (or being called drug powder) be seated in outer cartridge case, can vibrate fully, thus make it to flow into more uniformly and stably in described quantitative medicine groove.
Shown in Fig. 1, Fig. 2 or Fig. 4, described spring, vibration gear and rotating disk are coaxially set.
Shown in Fig. 1,2, the crown of described upper and lower vibration tooth is arranged in opposite directions, forms a single direction ratchet rotational motion secondary.
Further, described upper vibration tooth, with the center of rotation of described rotating disk for the center of circle, ring-type is distributed on the lower surface of described rotating disk; Described lower vibration tooth, with the center of rotation of described vibration gear for the center of circle, ring-type is distributed on the upper surface of described vibration gear.
Shown in Fig. 1, Fig. 2, the upper and lower vibration tooth described in it is unidirectional inclined-plane tooth.
The unidirectional inclined-plane tooth arranged in opposite directions owing to adopting two groups of crowns produces and clashes into and produce percussion vibration, be the conventional means in Machine Design, therefore its operating principle, process and vibration genesis mechanism no longer describes at this.
Because the technical solution of the utility model have employed master and slave vibrating mass structure, dual-vibration is carried out to medicine storage unit, can guarantee better medicine storage unit in each administration process of whole powder spray doser supply the metering accuracy of medicated powder dosage; By rotating disk, overall percussive vibration is carried out to runner lower member, better body vibration effect can be produced, and the requirement to vibration component Material Strength can be reduced, be conducive to the design of product, manufacture and reduction manufacturing cost; By the setting of interior cartridge case, also the workload of the Design of Mechanical Structure change carried out needed for the change because of loaded drug powder mobility can be reduced, add the adaptability of powder spray doser to wider drug powder kind, overcome adverse effect administration metering accuracy brought due to powder spray powder flowbility difference.
This utility model can be widely used in design, the manufacture field of the powder spray doser of all size.
Claims (10)
1. two vibration medicine storage unit of a powder spray doser, described powder spray doser comprises and is arranged on medicated powder storage capsule in doser housing and administration gauge assembly, suction nozzle is had in the arranged outside of housing, the inside of housing is provided with flow path features, and flow path features successively gas circuit connects air inlet, administration gauge assembly and suction nozzle; It is characterized in that:
Described housing is made up of upper cover, middle shell and lower house, and on described lower house, suit arranges a spiral cover;
Described spiral cover sets gradually spring, a vibration gear and a rotating disk;
Described spring housing dress is arranged on the central rotating shaft of described vibration gear;
On the upper surface of described vibration gear, be provided with the lower vibration tooth of a circle projection;
On the lower surface of described rotating disk, be provided with the upper vibration tooth of a circle projection; Circumferentially ratchet is provided with at described rotating disk;
The upper surface of described rotating disk is provided with multiple quantitative medicine groove, described multiple quantitative medicine groove with the central shaft of rotating disk for the center of circle, along the circumference uniform distribution of rotating disk;
Above described rotating disk, arrange runner lower member and runner upper member, described runner lower member and runner upper member fasten and fix as one, and form a complete runner gas circuit;
Described runner lower member arranges a medicated powder storage capsule;
Described medicated powder storage capsule at least comprises the outer cartridge case be fixed on described runner lower member and the cartridge case being arranged in outer cartridge case, and described interior cartridge case is nested in described outer cartridge case, and described interior cartridge case can move freely in described outer cartridge case;
Described vibration gear serves as principal oscillation parts, and described interior cartridge case serves as from vibrating mass;
Described spiral cover, spring, vibration gear, rotating disk and the inside and outside cartridge case be arranged on described runner lower member, form two vibration medicine storage unit of described powder spray doser;
The lower end of described outer cartridge case is provided with the lower open end running through described runner lower member, and described lower open end is positioned at multiple quantitative medicine groove distribution place, described rotating disk upper surface circumferentially.
2. according to two vibration medicine storage unit of powder spray doser according to claim 1, it is characterized in that described two vibration medicine storage unit, in medicated powder storage capsule, be also provided with and can serve as from vibrating mass the interior cartridge case of synchronously free vibration.
3., according to two vibration medicine storage unit of powder spray doser according to claim 1, it is characterized in that described spring, vibration gear and rotating disk are coaxially set.
4., according to two vibration medicine storage unit of powder spray doser according to claim 1, it is characterized in that the crown of described upper and lower vibration tooth is arranged in opposite directions, form a single direction ratchet rotational motion secondary.
5., according to two vibration medicine storage unit of powder spray doser according to claim 1, it is characterized in that described upper vibration tooth, with the center of rotation of described rotating disk for the center of circle, ring-type is distributed on the lower surface of described rotating disk; Described lower vibration tooth, with the center of rotation of described vibration gear for the center of circle, ring-type is distributed on the upper surface of described vibration gear.
6., according to two vibration medicine storage unit of powder spray doser according to claim 1, it is characterized in that described upper and lower vibration tooth is unidirectional inclined-plane tooth.
7. according to two vibration medicine storage unit of powder spray doser according to claim 1, it is characterized in that the upper end at described outer cartridge case, a base cover is set, described rotating disk, outer cartridge case and base cover form an enclosed space, in described enclosed space, described interior cartridge case can freely move.
8., according to two vibration medicine storage unit of powder spray doser according to claim 1, it is characterized in that described quantitative medicine groove is the blind hole structure being arranged on rotating disk upper surface.
9. according to two vibration medicine storage unit of powder spray doser according to claim 1, it is characterized in that the lower ending opening diameter of described outer cartridge case is less than the opening diameter of outer cartridge case upper end, the longitudinal profile structure of described outer cartridge interior cavity is a up big and down small inversion isosceles trapezoidal structure.
10. according to two vibration medicine storage unit of powder spray doser according to claim 1, it is characterized in that described interior cartridge case is the tubular structure of a hollow, its lower end diameter, be less than the upper end diameter of interior cartridge case, the longitudinal profile structure of described interior cartridge wall is a up big and down small inversion isosceles trapezoidal structure.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520460093.6U CN204766907U (en) | 2015-06-30 | 2015-06-30 | Powder spray is dosed two vibrations of device and is stored up prescriptions unit |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520460093.6U CN204766907U (en) | 2015-06-30 | 2015-06-30 | Powder spray is dosed two vibrations of device and is stored up prescriptions unit |
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| Publication Number | Publication Date |
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| CN204766907U true CN204766907U (en) | 2015-11-18 |
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| CN201520460093.6U Active CN204766907U (en) | 2015-06-30 | 2015-06-30 | Powder spray is dosed two vibrations of device and is stored up prescriptions unit |
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Address after: 201203 Shanghai City, Pudong New Area Zhangjiang hi tech park Zuchongzhi Road No. 1500 Building 8 Room 107 Patentee after: Shanghai Chen state pharmaceutical Polytron Technologies Inc Address before: 201203 Shanghai City, Pudong New Area Zhangjiang hi tech park Zuchongzhi Road No. 1500 Building 8 Room 107 Patentee before: Shanghai Chenpon Pharmaceutical Technology Co., Ltd. |