CN104970768B - A kind of half blood circulation inside body environmental organism intervention material experimental provision - Google Patents
A kind of half blood circulation inside body environmental organism intervention material experimental provision Download PDFInfo
- Publication number
- CN104970768B CN104970768B CN201510234025.2A CN201510234025A CN104970768B CN 104970768 B CN104970768 B CN 104970768B CN 201510234025 A CN201510234025 A CN 201510234025A CN 104970768 B CN104970768 B CN 104970768B
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- passage
- bottom plate
- cover plate
- blood
- experimental provision
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01M—TESTING STATIC OR DYNAMIC BALANCE OF MACHINES OR STRUCTURES; TESTING OF STRUCTURES OR APPARATUS, NOT OTHERWISE PROVIDED FOR
- G01M99/00—Subject matter not provided for in other groups of this subclass
- G01M99/008—Subject matter not provided for in other groups of this subclass by doing functionality tests
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Physics & Mathematics (AREA)
- Medical Informatics (AREA)
- Biophysics (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The invention discloses a kind of half blood circulation inside body environmental organism intervention material experimental provision, blood compatibility for biomedical engineering animal body implant devices is evaluated, it is made up of bottom plate (1) and the cover plate (2) being interlocked with bottom plate, bottom plate cover plate is fastened to form passage (3), i.e., passage is put together by the two parts up and down for being located at cover plate and bottom plate respectively；Channel interior is provided with the groove (4) of embedded device to be implanted；Passage both ends are respectively arranged with the hose connection (5) of proximal part and distal end that animal blood vessels are respectively connected to by flexible pipe.The passage of different-diameter of the present invention can be evaluated different size of cavity, easy to use, simple structure；Device places channel interior or a smooth circular tube chamber after completion, closer to states such as the shearing force under animal body vascular fluid state, flow velocity, directions；It can in vitro complete to evaluate, avoid the cumbersome of implant procedure, reduce the injury to animal body to the full extent.
Description
Technical field
The present invention relates to biomedical material experimental facilities, and in particular to half internal blood evaluation method and device.
Background technology
Biomedical engineering field animal body implantation instrument must carry out compatibility to it and comment before applied to clinic
Valency.The apparatus directly with contacting blood such as especially blood circulation system implantation instrument such as intravascular stent, cardiac valves, enters promoting circulation of blood
Liquid Compatibility Evaluation is particularly necessary.
At present, the mode evaluated implantation instrument is mainly implanted into animal body and evaluated, and such mode is not
Only implantation process it is cumbersome, it is necessary to have specialty anatomical knowledge, and to animal body injure it is huge, against humanitarianism.Therefore,
Invention one kind can be evaluated in vitro, and the device of and can simulation animal vivo environment is just imperative.Compatibility experiments are past
Carried out toward needs in different animal recipients, to obtain more comprehensively data, therefore, same device should be able to also meet
The different requirement of the parameter such as different animals cipient blood flow.
The content of the invention
In view of the deficiency above of prior art, the technical problems to be solved by the invention are to provide a kind of half internal blood and followed
Ring environment biology intervention material experimental provision, and with easy to use, the characteristics of simple structure.
Technical scheme is used by the present invention solves above-mentioned technical problem：
A kind of half blood circulation inside body environmental organism intervention material experimental provision, is implanted into for biomedical engineering animal body
The blood compatibility evaluation of device, it is characterised in that be made up of bottom plate 1 and the cover plate being interlocked with bottom plate (2), bottom plate cover plate
Fastening forms passage 3, i.e. passage is put together by the two parts up and down for being located at cover plate and bottom plate respectively；Channel interior is provided with embedding
Enter the groove 4 of device to be implanted；Passage both ends are respectively arranged with the proximal part and telecentricity that animal blood vessels are respectively connected to by flexible pipe
The hose connection 5 at end.
Further, the present invention has more than one passage.
So, the passage of different-diameter of the present invention can be evaluated different size of cavity, easy to use, construction letter
It is single；Device places channel interior or a smooth circular tube chamber after completion, closer under animal body vascular fluid state
Shearing force, flow velocity, the state such as direction；It can in vitro complete to evaluate, avoid the cumbersome of implant procedure, subtract to the full extent
The small injury to animal body.
Brief description of the drawings
Fig. 1 is that one embodiment of patent of invention closes the overall structure diagram of state.
Fig. 2 is that Fig. 1 removes the internal structure schematic diagram after cover plate, (size marking mm).
Fig. 3 is embedded apparatus and completes the generally longitudinally sectional view after flexible pipe installation.
Fig. 4 is embedded apparatus and completes the overall transverse sectional view after flexible pipe installation.
Fig. 5 be embodiment structural detail figure, (size marking mm).
Embodiment
With triple channel blood evaluating apparatus combination drawings and Examples, the invention will be further described below：
The present embodiment is related to a kind of half internal blood evaluating apparatus of triple channel as shown in figure 1, the internal diameter of three passages is by small
To greatly once for 3mm, 3.5mm, 4mm to adapt to the demand of three kinds of rabbit dog pig different receptor blood evaluation.As shown in Fig. 2
The longitudinal length of groove is 5mm, and the spacing between adjacent two groove of same passage is 5mm, and the recessed depth of groove is 0.5mm.It is logical
Road both ends set longitudinal length 5mm, and radius ratio respective channel radius increases 0.5mm flexible pipe insert port, it is ensured that internal diameter and passage
The consistent flexible pipe of internal diameter can be inserted smoothly.
Bottom plate is embedded in apparatus to be evaluated, and it is consistent logical as shown in Fig. 3 to form internal diameter with insertion flexible pipe after cover plate bonding
Road.Base plate thickness 6mm, cover sheet thickness 6mm, gross thickness 12mm.Each the 1/2 of circular channel and groove be distributed on bottom plate and cover plate it
On.Device wide 32mm, long 75mm.
In practical operation, following steps can be used：
Step 1: selecting the suitable passage of diameter according to the build of receptor, CBF etc., apparatus to be evaluated is embedded in
In backplane channel groove.
Step 2: cover plate and bottom plate are bonded, the groove on cover plate is fitted close with apparatus to be evaluated, bottom plate, cover plate, is treated
Evaluation apparatus forms circular channel together.
Step 3: placing a device into incubator, temperature adjusts, insulation enough time consistent with receptor body temperature, to be installed
Put temperature be raised to it is consistent with receptor body temperature.
Step 4: flexible pipe is accessed at passage both ends, input access animal proximal part, treat that blood flows out output end emptying passage
In air after by output end access receptor distal end.
Step 5: keeping blood circulation, blood evaluation is completed.
Obviously, implement using it is of the invention when should also coordinate corresponding auxiliary facility and technological means, text of the present invention is chatted
These corresponding auxiliary facilities and technological means are considered as conventional technology in stating.Do not depart from the present invention spirit and
In the case of scope, those skilled in the art without departing from the scope and spirit of the invention, it is carried out on
The a variety of obvious modifications or change of form and details all should be fallen within the scope and spirit of the invention.
Claims (2)
- A kind of 1. half blood circulation inside body environmental organism intervention material experimental provision, for biomedical engineering animal body implanting device The blood compatibility evaluation of part, it is characterised in that be made up of bottom plate (1) and the cover plate (2) being interlocked with bottom plate, bottom plate cover plate is buckled Conjunction forms circular channel (3), i.e. passage is put together by the two parts up and down for being located at cover plate and bottom plate respectively；Channel interior is set There is the groove (4) of embedded device to be implanted；Passage both ends are respectively arranged with the proximal part that animal blood vessels are respectively connected to by flexible pipe With the hose connection (5) of distal end；With more than one passage；The passage is arranged by increasing diameter, with meet it is different by The different demand of body animal blood uninterrupted.
- 2. half blood circulation inside body environmental organism intervention material experimental provision according to claim 1, it is characterised in that institute State that groove (4) depth is consistent with thickness of detector to be implanted, the consistent passage of internal diameter is formed after device insertion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510234025.2A CN104970768B (en) | 2015-05-11 | 2015-05-11 | A kind of half blood circulation inside body environmental organism intervention material experimental provision |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510234025.2A CN104970768B (en) | 2015-05-11 | 2015-05-11 | A kind of half blood circulation inside body environmental organism intervention material experimental provision |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104970768A CN104970768A (en) | 2015-10-14 |
| CN104970768B true CN104970768B (en) | 2018-02-06 |
Family
ID=54268140
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510234025.2A Expired - Fee Related CN104970768B (en) | 2015-05-11 | 2015-05-11 | A kind of half blood circulation inside body environmental organism intervention material experimental provision |
Country Status (1)
| Country | Link |
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| CN (1) | CN104970768B (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201477783U (en) * | 2009-07-10 | 2010-05-19 | 中国人民解放军第三军医大学第一附属医院 | Flow chamber device for simulating human microcirculation blood flow |
| CN102018999A (en) * | 2009-09-11 | 2011-04-20 | 洪小鹏 | Medical apparatus in parallel with vessels |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11051733B2 (en) * | 2008-01-18 | 2021-07-06 | Wake Forest University Health Sciences | Isolating and purifying cells for therapy |
| AU2010322460B2 (en) * | 2009-11-17 | 2015-05-28 | Harvard Apparatus Regenerative Technology, Inc. | Bioreactors, systems, and methods for producing and/or analyzing organs |
| WO2014111518A1 (en) * | 2013-01-17 | 2014-07-24 | Medibiome Ab | Tissue bioreactor |
-
2015
- 2015-05-11 CN CN201510234025.2A patent/CN104970768B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN201477783U (en) * | 2009-07-10 | 2010-05-19 | 中国人民解放军第三军医大学第一附属医院 | Flow chamber device for simulating human microcirculation blood flow |
| CN102018999A (en) * | 2009-09-11 | 2011-04-20 | 洪小鹏 | Medical apparatus in parallel with vessels |
Non-Patent Citations (3)
| Title |
|---|
| an ex vivo narrow-slit flow device for evaluation of blood-material interactions;R.S. Wilson et al;《American Society for Artificial Internal Organs》;19821231;第28卷;420-425 * |
| 医疗器械血液相容性评价与试验——解读GB/T 16886.4-2003/ISO 10993-4:2002;由少华;《中国医疗器械信息》;20061231;第12卷(第12期);49-54 * |
| 生物材料血液相容性评价方法的研究;奚廷斐;《生物医学工程学杂志》;19870402;第4卷(第1期);42-48 * |
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| CN104970768A (en) | 2015-10-14 |
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Granted publication date: 20180206 Termination date: 20200511 |