CN104970768A - Experimental device for semi in-vivo blood circulation environmental-biology intervention material - Google Patents
Experimental device for semi in-vivo blood circulation environmental-biology intervention material Download PDFInfo
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- CN104970768A CN104970768A CN201510234025.2A CN201510234025A CN104970768A CN 104970768 A CN104970768 A CN 104970768A CN 201510234025 A CN201510234025 A CN 201510234025A CN 104970768 A CN104970768 A CN 104970768A
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- channel
- passage
- blood circulation
- cover plate
- intervention material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/48—Other medical applications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01M—TESTING STATIC OR DYNAMIC BALANCE OF MACHINES OR STRUCTURES; TESTING OF STRUCTURES OR APPARATUS, NOT OTHERWISE PROVIDED FOR
- G01M99/00—Subject matter not provided for in other groups of this subclass
- G01M99/008—Subject matter not provided for in other groups of this subclass by doing functionality tests
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- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Heart & Thoracic Surgery (AREA)
- Molecular Biology (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Physics & Mathematics (AREA)
- Medical Informatics (AREA)
- Biophysics (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The invention discloses an experimental device for a semi in-vivo blood circulation environmental-biology intervention material. The experimental device is used for blood compatibility evaluation for an embedded device in an animal body in biomedical engineering. The experimental device is composed of a bottom plate (1) and a cover plate (2) buckled with the bottom plate (1). The bottom plate and the cover plate are buckled to form a channel (3), that is to say, the channel is formed by an upper portion and a lower portion which are located on the cover plate and the bottom plate respectively. A groove (4) used for embedding the device to be implanted is formed in the channel. The two ends of the channel are both provided with a tube connector (5), and the tube connectors are jointed up the proximal end and the distal end of the animal blood vessel respectively. According to the experimental device for the semi in-vivo blood circulation environmental-biology intervention material, evaluation on cavities with different sizes can be conducted through channels with different diameters, the use is convenient, and the construction is simple; the inside of the channel is still a smooth circular tube cavity which is closer to the states such as shear force, flow rate and direction at blood vessel fluid state of the animal body when the device is placed in the channel; evaluation can be conducted in vitro, complication on implanting programs is avoided, and harm on the animal body is reduced to the largest extent.
Description
Technical field
The present invention relates to biomedical material experimental facilities, be specifically related to the evaluation methodology of halfbody inner blood and device.
Background technology
Biomedical engineering field animal body implantation instrument be applied to clinical before, the evaluation of the compatibility must be carried out to it.Especially blood circulation implantation instrument is as intravascular stent, and cardiac valve etc. directly and the apparatus of contacting blood, carry out blood compatibility evaluation particularly necessary.
At present, the mode evaluated implantation instrument is mainly implanted in animal body and is evaluated, and such mode not only implantation process is loaded down with trivial details, needs the anatomical knowledge of specialty, and huge to animal body injury, against humanitarianism.Therefore, invention one can be evaluated in vitro, again can the device of simulated animal internal milieu just imperative.Compatibility experiments often needs to carry out in different animal recipient, and to obtain data more comprehensively, therefore, same device also should be able to meet the different instructions for use of the parameters such as different animals cipient blood flow.
Summary of the invention
In view of the above deficiency of prior art, technical problem to be solved by this invention is to provide a kind of halfbody inner blood circulation environmental organism intervention material experimental provision, and makes it to have easy to use, simply constructed feature.
The present invention solves the problems of the technologies described above adopted technical scheme:
A kind of halfbody inner blood circulation environmental organism intervention material experimental provision, for the blood compatibility evaluation of biomedical engineering animal body implant devices, it is characterized in that, be made up of base plate 1 and the cover plate (2) that is interlocked with base plate, base plate cover plate fastens and forms passage 3, and namely passage is put together by the two parts up and down laying respectively at cover plate and base plate; Channel interior is provided with the groove 4 embedding device to be implanted; Passage two ends are respectively arranged with accesses the proximal part of animal blood vessels and the hose connection 5 of distal end respectively by flexible pipe.
Further, the present invention has more than one passage.
Like this, the passage of different-diameter of the present invention can be evaluated the cavity of different size, easy to use, simple structure; Device placed after channel interior or a level and smooth circular tube chamber, more press close to the shearing force under animal body vascular fluid state, flow velocity, the states such as direction; Evaluation can be completed in vitro, avoid the loaded down with trivial details of implant procedure, reduce the injury to animal body to the full extent.
Accompanying drawing explanation
Fig. 1 is the overall structure schematic diagram that an embodiment of patent of invention closes state.
Fig. 2 is the internal structure schematic diagram after Fig. 1 removes cover plate, (size marking is mm).
Fig. 3 is the overall longitudinal sectional view after embedding apparatus and completing flexible pipe installation.
Fig. 4 is the overall transverse sectional view after embedding apparatus and completing flexible pipe installation.
Fig. 5 is the structural detail figure of embodiment, (size marking is mm).
Detailed description of the invention
Below with triple channel blood evaluating apparatus by reference to the accompanying drawings and embodiment the invention will be further described:
The present embodiment relates to a kind of triple channel halfbody inner blood evaluating apparatus as shown in Figure 1, and the internal diameter of three passages is ascending once for 3mm, 3.5mm, 4mm are to adapt to the demand of the different receptor blood evaluation of rabbit Canis familiaris L. pig three kinds.As shown in Figure 2, the longitudinal length of groove is 5mm, and the spacing between adjacent two grooves of same passage is 5mm, and it is 0.5mm that groove is recessed into the degree of depth.Passage two ends arrange longitudinal length 5mm, and radius ratio respective channel radius increases the flexible pipe insert port of 0.5mm, guarantee that the internal diameter flexible pipe consistent with channel internal diameter can insert smoothly.
Base plate embeds apparatus to be evaluated, inserts flexible pipe form the consistent passage as shown in Fig. 3 of internal diameter with cover plate after bonding.Base plate thickness 6mm, cover sheet thickness 6mm, gross thickness 12mm.Each 1/2 of circular channel and groove is distributed on base plate and cover plate.The wide 32mm of device, long 75mm.
In practical operation, can following steps be adopted:
Step one, build according to receptor, blood flow etc. select the passage that diameter is suitable, are embedded in backplane channel groove by apparatus to be evaluated.
Step 2, cover plate and base plate are bonded, the groove on cover plate and apparatus to be evaluated closely cooperate, base plate, cover plate, and apparatus to be evaluated forms circular channel together.
Step 3, device is put into couveuse, temperature is adjusted consistent with receptor body temperature, is incubated enough time, treats that unit temp is raised to consistent with receptor body temperature.
Step 4, passage two ends access flexible pipe, input access animal proximal part, accesses the distal end of receptor after the air that blood flows out in outfan emptying passage by outfan.
Step 5, maintenance blood circulation, complete blood evaluation.
Obviously, implement also should coordinate corresponding auxiliary facility and technological means when using of the present invention, in the describing of text of the present invention, these corresponding auxiliary facilities and technological means have been considered as conventional technological means.Without departing from the spirit and scope of the present invention; those skilled in the art are not when departing from scope and spirit of the present invention, and all apparent amendment about form and details carry out it or change all should drop within protection scope of the present invention.
Claims (4)
1. a halfbody inner blood circulation environmental organism intervention material experimental provision, for the blood compatibility evaluation of biomedical engineering animal body implant devices, it is characterized in that, be made up of base plate (1) and the cover plate (2) that is interlocked with base plate, base plate cover plate fastens and forms passage (3), and namely passage is put together by the two parts up and down laying respectively at cover plate and base plate; Channel interior is provided with the groove (4) embedding device to be implanted; Passage two ends are respectively arranged with accesses the proximal part of animal blood vessels and the hose connection (5) of distal end respectively by flexible pipe.
2. halfbody inner blood circulation environmental organism intervention material experimental provision according to claim 1, it is characterized in that, described groove (4) degree of depth is consistent with thickness of detector to be implanted, and device forms the consistent passage of internal diameter after embedding.
3. halfbody inner blood circulation environmental organism intervention material experimental provision according to claim 1, is characterized in that having more than one passage.
4. halfbody inner blood circulation environmental organism intervention material experimental provision according to claim 3, is characterized in that, described multiple passage presses increasing diameter arrangement, the demand varied in size with satisfied different receptor blood flow.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510234025.2A CN104970768B (en) | 2015-05-11 | 2015-05-11 | A kind of half blood circulation inside body environmental organism intervention material experimental provision |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510234025.2A CN104970768B (en) | 2015-05-11 | 2015-05-11 | A kind of half blood circulation inside body environmental organism intervention material experimental provision |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104970768A true CN104970768A (en) | 2015-10-14 |
| CN104970768B CN104970768B (en) | 2018-02-06 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510234025.2A Expired - Fee Related CN104970768B (en) | 2015-05-11 | 2015-05-11 | A kind of half blood circulation inside body environmental organism intervention material experimental provision |
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| CN (1) | CN104970768B (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090186065A1 (en) * | 2008-01-18 | 2009-07-23 | Wake Forest University Health Sciences | Isolating and purifying cells for therapy |
| CN201477783U (en) * | 2009-07-10 | 2010-05-19 | 中国人民解放军第三军医大学第一附属医院 | Flow chamber device for simulating human microcirculation blood flow |
| CN102018999A (en) * | 2009-09-11 | 2011-04-20 | 洪小鹏 | Medical apparatus in parallel with vessels |
| US20130177972A1 (en) * | 2009-11-17 | 2013-07-11 | David Green | Bioreactors, systems, and methods for producing and/or analyzing organs |
| WO2014111518A1 (en) * | 2013-01-17 | 2014-07-24 | Medibiome Ab | Tissue bioreactor |
-
2015
- 2015-05-11 CN CN201510234025.2A patent/CN104970768B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090186065A1 (en) * | 2008-01-18 | 2009-07-23 | Wake Forest University Health Sciences | Isolating and purifying cells for therapy |
| CN201477783U (en) * | 2009-07-10 | 2010-05-19 | 中国人民解放军第三军医大学第一附属医院 | Flow chamber device for simulating human microcirculation blood flow |
| CN102018999A (en) * | 2009-09-11 | 2011-04-20 | 洪小鹏 | Medical apparatus in parallel with vessels |
| US20130177972A1 (en) * | 2009-11-17 | 2013-07-11 | David Green | Bioreactors, systems, and methods for producing and/or analyzing organs |
| WO2014111518A1 (en) * | 2013-01-17 | 2014-07-24 | Medibiome Ab | Tissue bioreactor |
Non-Patent Citations (3)
| Title |
|---|
| R.S. WILSON ET AL: "an ex vivo narrow-slit flow device for evaluation of blood-material interactions", 《AMERICAN SOCIETY FOR ARTIFICIAL INTERNAL ORGANS》 * |
| 奚廷斐: "生物材料血液相容性评价方法的研究", 《生物医学工程学杂志》 * |
| 由少华: "医疗器械血液相容性评价与试验——解读GB/T 16886.4-2003/ISO 10993-4:2002", 《中国医疗器械信息》 * |
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| Publication number | Publication date |
|---|---|
| CN104970768B (en) | 2018-02-06 |
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Granted publication date: 20180206 Termination date: 20200511 |