CN1049601C

CN1049601C - External medicine for hyperosteogeny and preparation method thereof

Info

Publication number: CN1049601C
Application number: CN98110042A
Authority: CN
Inventors: 刘学通
Original assignee: Individual
Current assignee: Individual
Priority date: 1998-01-16
Filing date: 1998-01-16
Publication date: 2000-02-23
Anticipated expiration: 2018-01-16
Also published as: CN1190594A

Abstract

The present invention relates to an externally applied medicine for treating hyperostosis and a preparation method thereof. The externally applied medicine for treating hyperostosis mainly comprises active components extracted from the following traditional Chinese medicinal materials of the proportion by weight as raw materials by a conventional extraction method: motherwort herb, giant knotweed rhizome, spanishneedles herb, clematis root, ningpo yam rhizome, babylon weeping willow root, argy wormwood leaf, dried ginger, garden balsam stem, chuanxiong rhizome, red sage root, common floweringquince fruit, frankincense, myrrh, honeycomb of paper wasps, musk, draconis resin, dahurian angelica, wolfberry bark and elm bark. The externally applied medicine for treating hyperostosis has special curative effect on hyperostosis, and has favorable curative effect on prolapse of intervertebral disc, osteonecrosis of the femoral head, various kinds of arthritis, pain in the neck, the shoulder, the waist and the lower extremity, traumatic injuries, sciatica, lumbar muscle strains, tendovaginitis, hemorrhoids and trachitis.

Description

A kind of external used medicine for the treatment of hyperosteogeny and preparation method thereof

The present invention relates to a kind of external used medicine for the treatment of hyperosteogeny, commodity are called " Liu Shi-muscles and bones is hindered blood stasis dispelling cream ", specifically, it be a kind of be the external used medicine that raw material is made with the Chinese crude drug, relate to the preparation method of this medicine in addition.

Hyperosteogeny is a kind of common frdquently encountered disease, add up according to WHO, loyal bones matter hypertrophy patient accounts for 10% of total population, China 40-60 year middle-aged and elderly people 90% equal loyalty has hyperosteogeny, this sick clinical manifestation is dizzy, headache, feel sick, tinnitus, dim eyesight, neck-shoulder pain, lumbago and leg pain, numb limbs and tense tendons, limitation of activity, and is very painful.Its formation is because long-term work makes the osteoarthrosis wearing and tearing, cartilage is degenerated gradually, grow bony spur at the edge, joint, under the stimulation of bony spur, the pain increased, can cause late period hydrarthrosis, deformity, activity to be obstructed, if bony spur length is at the cervical vertebra position, also can oppress spinal cord or spinal nerves, tremulous pulse, thereby cause above-mentioned clinical symptoms.In the existing therapy to this disease, operative therapy not only has certain risk and expense costliness, and the bony spur that also can regrow after the treatment; Alleviated misery greatly although the mechanical traction therapy becomes intervertebral foramina, curative effect is not consolidated, and also has side effect; The oral drugs therapy, as disclosed treatment hyperosteogeny pill among the CN1073099A, curative effect is slower, and gastrointestinal is had stimulation; Articular cavity blocking therapy Aeroseb-Dex generally commonly used has certain misery when not only treating, life-time service also has destruction to cartilage.Although the Chinese medicine lotion for external use agent of also known many treatment hyperosteogenys in the prior art, as the disclosed a kind of hyperosteogeny plaster that prevents of CN1141186A, this plaster is traditional plaster, contains toxic heavy metal lead; And the disclosed bony-spur plaster of CN1064618A and CN1031186A does not contain the toxicity heavy metal lead through pipe, but flavour of a drug are huge, and cost is higher.

Purpose of the present invention just provides the external used medicine that does not contain the toxicity heavy metal lead that a kind of curative effect is given prominence to stable and the less compatibility proper treatment of flavour of a drug hyperosteogeny.

Another object of the present invention provides the preparation method of this medicine.

It is the active part that raw material adopts conventional extracting method to make that drug main of the present invention will contain the Chinese crude drug of selecting following weight ratio for use: Herba Leonuri 250-350, Herba Bidentis Bipinnatae 150-250, Rhizoma Polygoni Cuspidati 150-250, Radix Clematidis 150-250, Rhizoma Dioscoreae Nipponicae 150-250, Radix Salicis Babylonicae 250-350, Cortex Lycii 250-350, Herba speranskiae tuberculatae 150-250, Folium Artemisiae Argyi 150-250, Rhizoma Zingiberis 1-5, Rhizoma Chuanxiong 150-250, Radix Salviae Miltiorrhizae 250-350, Fructus Chaenomelis 5-15, Olibanum 5-15, Myrrha 5-15, Radix Angelicae Dahuricae 5-15, Moschus 1-5, Sanguis Draxonis 3-10, Nidus Vespae 150-250, Cortex ulmi pumilae 200-300; Be preferably: Herba Leonuri 280-320, Herba Bidentis Bipinnatae 180-220, Rhizoma Polygoni Cuspidati 180-220, Radix Clematidis 180-220, Rhizoma Dioscoreae Nipponicae 180-220, Radix Salicis Babylonicae 280-320, Cortex Lycii 280-320, Herba speranskiae tuberculatae 180-220, Folium Artemisiae Argyi 180-220, Rhizoma Zingiberis 1-4, Rhizoma Chuanxiong 180-220, Radix Salviae Miltiorrhizae 280-320, Fructus Chaenomelis 8-12, Olibanum 8-12, Myrrha 8-12, Radix Angelicae Dahuricae 8-12, Moschus 1-2, Sanguis Draxonis 4-8, Nidus Vespae 180-220, Cortex ulmi pumilae 220-280; The best is: Herba Leonuri 300, Herba Bidentis Bipinnatae 200, Rhizoma Polygoni Cuspidati 200, Radix Clematidis 200, Rhizoma Dioscoreae Nipponicae 200, Radix Salicis Babylonicae 300, Cortex Lycii 300, Herba speranskiae tuberculatae 200, Folium Artemisiae Argyi 200, Rhizoma Zingiberis 2, Rhizoma Chuanxiong 200, Radix Salviae Miltiorrhizae 300, Fructus Chaenomelis 10, Olibanum 10, Myrrha 10, the Radix Angelicae Dahuricae 10, Moschus 1, Sanguis Draxonis 6, Nidus Vespae 200, Cortex ulmi pumilae 250.

Conventional extracting method of the present invention comprises decocting method, infusion process, percolation, reflux extraction, steam distillation, decoction and alcohol sedimentation technique and ethanol extract from water precipitation etc.The used extraction solvent of the present invention comprises water and Different concentrations of alcohol.Extraction time decides according to diverse ways.The decocting time of decocting method is 0.5-1.5 hour; Reflux extraction was generally 1-2 hour.

In addition, medicine of the present invention can also contain pharmaceutically acceptable various additives, for example promotes the penetration enhancer of skin permeation of drugs etc.

The various external preparation pharmaceutically that medicine of the present invention can be to use the conventional formulation technology of this area to make, wherein preferred dosage form is unguentum, Emulsion, aerosol, powder agent, lotion etc.

Medicine of the present invention has the effect of blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, hard masses softening and resolving, relieving rigidity of muscles and knitting bone, wind-damp dispelling, can treating both the principal and the secondary aspects of a disease at the same time, cervical vertebra, lumbar vertebra, kneed hyperosteogeny had unique effect, in addition, also intervertebral disk hernia, femur head necrosis, all kinds of arthritis, neck-shoulder pain, lumbago and leg pain, traumatic injury, sciatica, lumbar muscle strain, tenosynovitis and hemorrhoid, tracheitis had curative effect preferably, through seven tame hospital clinic clinical practices, Qingdao City medicine inspecting institute and the military region, Jinan medicine inspecting institute testing identity, this plaster is without any side effects to human body.Through the inventor clinical verification of patient surplus 30,000 is shown that curative effect of medication of the present invention is significantly stable, its white effective percentage is 96%, obvious effective rate 82%, and inefficiency is 4%.

Embodiment 1

1) press the weighing respectively of column weight amount: Herba Leonuri 3000g, Rhizoma Polygoni Cuspidati 2000g, Herba Bidentis Bipinnatae 2000g, Radix Clematidis 2000g, Rhizoma Dioscoreae Nipponicae 2000g, Radix Salicis Babylonicae 3000g, Folium Artemisiae Argyi 2000g, Rhizoma Zingiberis 20g, Herba speranskiae tuberculatae 2000g, Rhizoma Chuanxiong 2000g, Radix Salviae Miltiorrhizae 3000g Fructus Chaenomelis 100g, Olibanum 100g, Myrrha 100g, Nidus Vespae 2000g, Moschus 10g, Sanguis Draxonis 60g, Radix Angelicae Dahuricae 100g, Cortex Lycii 3000g, Cortex ulmi pumilae 2500g, standby:

2) get Herba Leonuri and add in the distillator, it is standby to extract volatile oil by the way of distillation, and it is standby that Cortex ulmi pumilae, Moschus and Sanguis Draxonis are ground into powder;

3) get Rhizoma Polygoni Cuspidati, Herba Bidentis Bipinnatae, Radix Clematidis, Rhizoma Dioscoreae Nipponicae, Radix Salicis Babylonicae, Folium Artemisiae Argyi, Rhizoma Zingiberis, Herba speranskiae tuberculatae, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Fructus Chaenomelis, Cortex Lycii, clean, soaked 2 hours; Other gets Olibanum, Myrrha, Nidus Vespae, the Radix Angelicae Dahuricae, grinds, and crosses 60 mesh sieves, the two is merged with decocting extraction method extraction three times, each one hour, merge three filtrates and add the elm corium farinosum to the stiff paste shape, add Moschus, Sanguis Draxonis and Herba Leonuri volatile oil again and stir evenly, obtain the pitchy soft extracts.

Claims

1. external used medicine for the treatment of hyperosteogeny, the active part that it is characterized in that it are that the Chinese crude drug with following weight ratio makes according to conventional extraction process: Herba Leonuri 250-350, Herba Bidentis Bipinnatae 150-250, Rhizoma Polygoni Cuspidati 150-250, Radix Clematidis 150-250, Rhizoma Dioscoreae Nipponicae 150-250, Radix Salicis Babylonicae 250-350, Cortex Lycii 250-350, Herba speranskiae tuberculatae 150-250, Folium Artemisiae Argyi 150-250, Rhizoma Zingiberis 1-5, Rhizoma Chuanxiong 150-250, Radix Salviae Miltiorrhizae 250-350, Fructus Chaenomelis 5-15, Olibanum 5-15, Myrrha 5-15, Radix Angelicae Dahuricae 5-15, Moschus 1-5, Sanguis Draxonis 3-10, Nidus Vespae 150-250, Cortex ulmi pumilae 200-300.

2. according to the medicine of claim 1, wherein its active part is to make according to conventional extraction process with the Chinese crude drug of following weight ratio: Herba Leonuri 280-320, Herba Bidentis Bipinnatae 180-220, Rhizoma Polygoni Cuspidati 180-220, Radix Clematidis 180-220, Rhizoma Dioscoreae Nipponicae 180-220, Radix Salicis Babylonicae 280-320, Cortex Lycii 280-320, Herba speranskiae tuberculatae 180-220, Folium Artemisiae Argyi 180-220, Rhizoma Zingiberis 1-4, Rhizoma Chuanxiong 180-220, Radix Salviae Miltiorrhizae 280-320, Fructus Chaenomelis 8-12, Olibanum 8-12, Myrrha 8-12, Radix Angelicae Dahuricae 8-12, Moschus 1-2, Sanguis Draxonis 4-8, Nidus Vespae 180-220, Cortex ulmi pumilae 220-280.

3. according to the medicine of claim 1, wherein its active part is to make according to conventional extraction process with the Chinese crude drug of following weight ratio: Herba Leonuri 300, Herba Bidentis Bipinnatae 200, Rhizoma Polygoni Cuspidati 200, Radix Clematidis 200, Rhizoma Dioscoreae Nipponicae 200, Radix Salicis Babylonicae 300, Cortex Lycii 300, Herba speranskiae tuberculatae 200, Folium Artemisiae Argyi 200, Rhizoma Zingiberis 2, Rhizoma Chuanxiong 200, Radix Salviae Miltiorrhizae 300, Fructus Chaenomelis 10, Olibanum 10, Myrrha 10, the Radix Angelicae Dahuricae 10, Moschus 1, Sanguis Draxonis 6, Nidus Vespae 200, Cortex ulmi pumilae 250.

4. preparation method for the treatment of the hyperosteogeny external used medicine, it comprises the following steps:

A) press the weighing respectively of row weight portion: Herba Leonuri 250-350, Herba Bidentis Bipinnatae 150-250, Rhizoma Polygoni Cuspidati 150-250, Radix Clematidis 150-250, Rhizoma Dioscoreae Nipponicae 150-250, Radix Salicis Babylonicae 250-350, Cortex Lycii 250-350, Herba speranskiae tuberculatae 150-250, Folium Artemisiae Argyi 150-250, Rhizoma Zingiberis 1-5, Rhizoma Chuanxiong 150-250, Radix Salviae Miltiorrhizae 250-350, Fructus Chaenomelis 5-15, Olibanum 5-15, Myrrha 5-15, Radix Angelicae Dahuricae 5-15, Moschus 1-5, Sanguis Draxonis 3-10, Nidus Vespae 150-250, Cortex ulmi pumilae 200-300, standby;

B) get Herba Leonuri and add in the distillator, it is standby to extract volatile oil by the way of distillation, and it is standby that Cortex ulmi pumilae, Moschus and Sanguis Draxonis are ground into powder;

C) get Rhizoma Polygoni Cuspidati, Herba Bidentis Bipinnatae, Radix Clematidis, Rhizoma Dioscoreae Nipponicae, Radix Salicis Babylonicae, Folium Artemisiae Argyi, Rhizoma Zingiberis, Herba speranskiae tuberculatae, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Fructus Chaenomelis, Cortex Lycii, clean, soaked 2 hours; Other gets Olibanum, Myrrha, Nidus Vespae, the Radix Angelicae Dahuricae and crosses 60 mesh sieves, the two is merged with decocting extraction method extraction three times, each-hour, merge three filtrates and add the elm corium farinosum to the stiff paste shape, add Moschus, Sanguis Draxonis and Herba Leonuri volatile oil again and stir evenly, obtain the pitchy soft extracts.

5. according to the method for claim 4, wherein selecting following parts by weight of Chinese traditional medicine material for use is raw material: Herba Leonuri 280-320, Herba Bidentis Bipinnatae 180-220, Rhizoma Polygoni Cuspidati 180-220, Radix Clematidis 180-220, Rhizoma Dioscoreae Nipponicae 180-220, Radix Salicis Babylonicae 280-320, Cortex Lycii 280-320, Herba speranskiae tuberculatae 180-220, Folium Artemisiae Argyi 180-220, Rhizoma Zingiberis 1-4, Rhizoma Chuanxiong 180-220, Radix Salviae Miltiorrhizae 280-320, Fructus Chaenomelis 8-12, Olibanum 8-12, Myrrha 8-12, Radix Angelicae Dahuricae 8-12, Moschus 1-2, Sanguis Draxonis 4-8, Nidus Vespae 180-220, Cortex ulmi pumilae 220-280.

6. according to the method for claim 4, wherein selecting following parts by weight of Chinese traditional medicine material for use is raw material: Herba Leonuri 300, Herba Bidentis Bipinnatae 200, Rhizoma Polygoni Cuspidati 200, Radix Clematidis 200, Rhizoma Dioscoreae Nipponicae 200, Radix Salicis Babylonicae 300, Cortex Lycii 300, Herba speranskiae tuberculatae 200, Folium Artemisiae Argyi 200, Rhizoma Zingiberis 2, Rhizoma Chuanxiong 200, Radix Salviae Miltiorrhizae 300, Fructus Chaenomelis 10, Olibanum 10, Myrrha 10, the Radix Angelicae Dahuricae 10, Moschus 1, Sanguis Draxonis 6, Nidus Vespae 200, Cortex ulmi pumilae 250.