CN104959502A - Ultrasonic vibration-assisted forming process of pure-titanium solid microneedles - Google Patents
Ultrasonic vibration-assisted forming process of pure-titanium solid microneedles Download PDFInfo
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- CN104959502A CN104959502A CN201510263694.2A CN201510263694A CN104959502A CN 104959502 A CN104959502 A CN 104959502A CN 201510263694 A CN201510263694 A CN 201510263694A CN 104959502 A CN104959502 A CN 104959502A
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Abstract
Provided is an ultrasonic vibration-assisted forming process of pure-titanium solid microneedles. The ultrasonic vibration-assisted forming process comprises following steps: A, machining a group of moulds used for preparation of pure-titanium solid microneedles; B, setting up an ultrasonic vibration-assisted forming system to be connected with moulds; C, pre-processing a pure-Ti sheet; D, placing the pre-processed pure-Ti sheet into the one group of moulds and adjusting ultrasound parameters and adopting a pier-squeezing preparation method in order to obtain the pure-titanium solid microneedles. Compared with a conventional forming process, the ultrasonic vibration-assisted forming process of pure-titanium solid microneedles has following beneficial effects: biocompatibility and mechanical intensity of the microneedles are improved by utilizing pure titanium as material; by adoption of an ultrasound-assisted plastic micro-forming process, flowing capacity of metal is improved and forming difficulty of the microneedles is reduced; by utilization of mould production, production efficiency is improved and production cost is decreased.
Description
Technical field
The present invention relates to metal forming, particularly relate to a kind of pure titanium solid microneedles forming technology auxiliary based on ultrasonic vibration.
Background technology
At medical field, modern biotechnology has produced very ripe and effective medicine, but effective transmission of a lot of medicine is by the restriction of delivery system up till now.Transdermal drug delivery system just becomes the study hotspot of delivery system with the advantage of its uniqueness, transdermal drug delivery system refers to medicine with given pace by skin, enters human circulation and produce a class preparation of drug effect through capillary absorbance.Compared with traditional administering mode, cutaneous penetration has many advantages: avoid the digested enzyme of stomach that produces because of oral administration to the decomposition of medicine, destruction and liver " first pass effect "; Avoid the pain because intravenous injection causes and infection; By control drug delivery speed, maintain constant blood concentration and increase curative effect; Reduce toxic and side effect and the gastrointestinal reaction of medicine; Interruptible price administration at any time improves the compliance etc. of patient.
In multiple Transdermal delivery systems, the advantages such as microneedle cutaneous system has the double dominant of injection and cutaneous penetration, quick with it, convenient and painless achieve larger progress.Research shows that microneedle drug imports can significantly improve drug transdermal speed and uptake, particularly shows good effect and application prospect in the preparation capable of permeating skin research field of the macromolecular substances such as protein, polypeptide and DNA.Tens of percutaneous plaster that is solid to hundreds of pieces or empty micropin composition is affixed on skin by microneedle cutaneous technology, by piercing through skin outermost layer, medicine is entered in body.
The material making micropin is a lot, mainly contains silicon, polymer and metal etc.Due to silicon processing technique comparative maturity, the preparation of micropin is initial to be launched around silicon materials more, but silicon is easily crisp, easily rupture when thrusting skin, the poor biocompatibility of silicon, and be not suitable as mould and copy in enormous quantities, these all limit the application of silicon micropin.Polymer micro needle has good biocompatibility, also can make various micropin, but due to the flexibility of polymer, its mechanical performance and intensity poor, not easily thrust skin.The general not frangibility of metal micro-needle, and a lot of metal such as titanium etc. has good biocompatibility, so metal micro-needle has very wide range of application.The method of current processing metal micropin mainly contains laser cutting, plating and ultraprecise machining.The working (machining) efficiency of the processing cost of these modes is all very low, adopts the method for metal forming then can significantly improve production efficiency to produce micropin, reduce production cost.
Metal micro-needle is in sub-millimeter meter range due to size characteristic, and its forming technology is than traditional forming difficulty, and main cause is: when the less surface to volume ratio of accessory size increases; For small size part, the adhesion between workpiece and instrument and surface tension etc. enlarge markedly; The impact of crystallite dimension is remarkable, can not regard isotropic uniformly continous body as traditional handicraft as; Surface of the work stores lubricant relative difficulty.In the plastic forming process of micropin, now introduce ultrasonic vibration then can reach the object improved technological effect, improve the quality of products.Ultrasonic vibration Plastic Forming processing refers in traditional plastic working forming technology, and workpiece or mould initiatively apply the ultrasonic vibration of direction, frequency and adjustable amplitude.It has been generally acknowledged that ultrasonic vibrating machining technology has the following advantages relative to conventional metals plastic forming process: the friction reduce plastic force, reduce metal flow stress, reducing between workpiece and mould, expand the metal material Plastic Forming range of work, improve metal material plastic forming ability, good product surface quality and higher dimensional accuracy can be obtained.Therefore, in pure titanium solid microneedles forming technology, introduce ultrasonic vibration, contribute to producing qualified part, one-tenth product in enormous quantities reduces costs.
Summary of the invention
Object of the present invention, exactly in order to overcome the deficiency that above-mentioned prior art exists, provides a kind of pure titanium solid microneedles forming technology auxiliary based on ultrasonic vibration.
In order to achieve the above object, present invention employs following technical scheme: a kind of pure titanium solid microneedles forming technology auxiliary based on ultrasonic vibration, comprises the following steps:
A, process one group of mould for the preparation of pure titanium solid microneedles;
B, build a ultrasonic vibration assisted forming system and be connected with mould;
C, pretreatment is carried out to Titanium board;
D, be positioned in mould by pretreated Titanium board, adjustment ultrasound parameter, the method adopting pier to squeeze prepares pure titanium solid microneedles.
Mould described in steps A comprises punch and die, and punch and blank contact surface are plane, and die, with V-arrangement blank holder, die has the die cavity matched with described pure titanium solid microneedles size.
Described punch and die adopt the processing of fine electric spark technology, and it is 0.2 μm that concave die cavity and punch and blank contact surface reach roughness grade number after grinding, and the punch-die upper and lower surface depth of parallelism is 0.01mm.
The assisted forming system of ultrasonic vibration described in step B comprises supersonic generator, ultrasonic transducer and the ultrasonic transformer that order is connected, and support, ultrasonic transducer and ultrasonic transformer rack-mount, ultrasonic transformer and die assembly also provide ultrasonic vibration to mould, and described ultrasonic vibration assisted forming system is in overall resonance state.
Pretreatment described in step C is that Titanium board is obtained equiax crystal titanium plate through full annealing recrystallization, then processes and is of a size of 2mm × 2mm ~ 3mm × 3mm, roughness grade is the Titanium board of 1.6 ~ 6.3, and clean up.
Described cleaning up is clean with alcohol washes.
The diameter of the pure titanium solid microneedles prepared in step D is 100 μm, and length is 100 ~ 200 μm.
Ultrasound parameter described in step D is: resonant frequency 20KHz, power 300 ~ 1000W.
It is exerted pressure to mould by omnipotent mechanics machine that pier described in step D squeezes, and pressure is 2 ~ 10KN.
Compared with prior art, the present invention has following beneficial effect:
1, adopt ultrasonic vibration to assist micropin Plastic Forming, effectively can reduce the technology difficulty that micropin is shaped; Adopt mould to produce simultaneously and can significantly improve production efficiency, reduce production cost, be conducive to batch production.
2, pure titanium is adopted to improve the biocompatibility of micropin as material; Add mechanical performance and the intensity of micropin.
Accompanying drawing explanation
Fig. 1 is mould therefor schematic diagram in the present invention;
The schematic diagram of ultrasonic vibration accessory system of Fig. 2 for building in the present invention;
The structural representation of the pure titanium solid microneedles of Fig. 3 prepared by the present invention.
Detailed description of the invention
The pure titanium solid microneedles forming technology that the present invention is based on ultrasonic vibration auxiliary first processes one group of mould for the preparation of pure titanium solid microneedles; Mould structure as shown in Figure 1, comprises punch 3 and die 1, and the contact surface of punch and blank is plane, and die, with V-arrangement blank holder 11, die has the die cavity 12 matched with pure titanium solid microneedles size.Above-mentioned punch and die adopt the processing of fine electric spark technology, and it is 0.2 μm that concave die cavity and punch and blank contact surface reach roughness grade number after grinding, and the punch-die upper and lower surface depth of parallelism is 0.01mm.
Meanwhile, build a ultrasonic vibration assisted forming system and be connected with mould; The composition of ultrasonic vibration assisted forming system as shown in Figure 2, comprise supersonic generator 5, ultrasonic transducer 6 and ultrasonic transformer 7 that order is connected, and support 8, ultrasonic transducer and ultrasonic transformer rack-mount, ultrasonic transformer is connected with mould and provides resonant ultrasonic ripple to mould.
In addition, pretreatment is carried out to Titanium board; Titanium board is obtained equiax crystal titanium plate through full annealing recrystallization, then processes and be of a size of 2mm × 2mm ~ 3mm × 3mm, roughness grade is the Titanium board of 1.6 ~ 6.3, and clean with alcohol washes.
Finally be positioned in mould by pretreated Titanium board 2, adjustment ultrasound parameter is: resonant frequency 20KHz, power 300 ~ 1000W.The method adopting pier to squeeze prepares pure titanium solid microneedles.The diameter of the pure titanium solid microneedles obtained is 100 μm, and length is 100 ~ 200 μm.It is exerted pressure to mould by omnipotent mechanics machine that above-mentioned pier squeezes, and pressure is 2 ~ 10KN.
Below by way of two specific embodiments, the invention will be further described:
Embodiment 1
1, cold work die steel Cr12 is adopted, the plane punch 3 needed for pure titanium solid microneedles and the die 1 with V-arrangement blank holder is gone out with micro EDM, then grinding is carried out to described die 1 and punch 3, make described punch 3, the roughness grade of die 1 is 0.2, the upper and lower surface depth of parallelism is 0.01mm; Described with the die 1 of V-arrangement blank holder being provided with the recess measure-alike with described pure titanium solid microneedles; Solid microneedles is of a size of diameter 100 μm, length 150 ~ 200 μm.
2, ultrasonic vibration accessory system specifically comprises: digital circuit full-bridge inverting supersonic generator, piezoelectric ceramic transducer, titanium alloy ultrasonic transformer.Above each several part keeps resonant condition, and is connected with punch by bolt, and support is used for erecting ultrasonic transducer and ultrasonic transformer.
3, pure titanium pretreatment: titanium plate is put into vacuum drying oven annealing recrystallization and obtain equiax crystal titanium plate, titanium plate is cut into the plate being of a size of 2mm × 2mm, roughness grade is 1.6, uses alcohol washes to the pure titanium sheet metal processed.
4, ultrasonic vibration accessory system, punch and die are arranged on omnipotent test machine for mechanism, pretreated pure titanium sheet metal 2 is placed between male and female mold 1,3, its resonant frequency is 20KHz, power is 300W ~ 500W to regulate supersonic generator to make, the pressure controlling omnipotent mechanics machine is 2 ~ 3KN, carry out pier to squeeze, stop after the power set by arrival; Titanium board after being squeezed by pier takes out, and namely obtains the pure titanium solid microneedles of required form, as shown in Figure 3.
Observed by SEM, obtain micropin size and surface quality information, whether checking micropin size meets the requirements.
Embodiment 2
1, cold work die steel Cr12 is adopted, the plane punch 3 needed for pure titanium solid microneedles and the die 1 with V-arrangement blank holder is gone out with micro EDM, then grinding is carried out to described die 1 and punch 3, make described punch 3, the roughness grade of die 1 is 0.2, the upper and lower surface depth of parallelism is 0.01mm; Described with the die 1 of V-arrangement blank holder being provided with the recess measure-alike with described pure titanium solid microneedles; Solid microneedles is of a size of diameter 100 μm, length 150 ~ 200 μm.
2, ultrasonic vibration accessory system specifically comprises: digital circuit full-bridge inverting supersonic generator, piezoelectric ceramic transducer, titanium alloy ultrasonic transformer.Above each several part keeps resonant condition, and is connected with punch by bolt, and support is used for erecting ultrasonic transducer and ultrasonic transformer.
3, pure titanium pretreatment: titanium plate is put into vacuum drying oven annealing recrystallization and obtain equiax crystal titanium plate, titanium plate is cut into the plate being of a size of 3mm × 3mm, roughness grade is 1.6, uses alcohol washes to the pure titanium sheet metal processed.
4, ultrasonic vibration accessory system, punch and die are arranged on omnipotent test machine for mechanism, pretreated pure titanium sheet metal 2 is placed between male and female mold 1,3, its resonant frequency is 20KHz, power is 500W ~ 1000W to regulate supersonic generator to make, the pressure controlling omnipotent mechanics machine is 5 ~ 10KN, carry out pier to squeeze, stop after the power set by arrival; Titanium board after being squeezed by pier takes out, and namely obtains the pure titanium solid microneedles of required form, as shown in Figure 3.
Observed by SEM, obtain micropin size and surface quality information, whether checking micropin size meets the requirements.
Claims (9)
1., based on the pure titanium solid microneedles forming technology that ultrasonic vibration is auxiliary, it is characterized in that: comprise the following steps:
A, process one group of mould for the preparation of pure titanium solid microneedles;
B, build a ultrasonic vibration assisted forming system and be connected with mould;
C, pretreatment is carried out to Titanium board;
D, be positioned in mould by pretreated Titanium board, adjustment ultrasound parameter, the method adopting pier to squeeze prepares pure titanium solid microneedles.
2. as claimed in claim 1 based on the pure titanium solid microneedles forming technology that ultrasonic vibration is auxiliary, it is characterized in that: mould described in steps A comprises punch and die, punch and blank contact surface are plane, die, with V-arrangement blank holder, die has the die cavity matched with described pure titanium solid microneedles size.
3. as claimed in claim 2 based on the pure titanium solid microneedles forming technology that ultrasonic vibration is auxiliary, it is characterized in that: described punch and die adopt the processing of fine electric spark technology, it is 0.2 μm that concave die cavity and punch and blank contact surface reach roughness grade number after grinding, and the punch-die upper and lower surface depth of parallelism is 0.01mm.
4. as claimed in claim 1 based on the pure titanium solid microneedles forming technology that ultrasonic vibration is auxiliary, it is characterized in that: the assisted forming system of ultrasonic vibration described in step B comprises supersonic generator, ultrasonic transducer and the ultrasonic transformer that order is connected, and support, ultrasonic transducer and ultrasonic transformer rack-mount, ultrasonic transformer and die assembly also provide ultrasonic vibration to mould, and described ultrasonic vibration assisted forming system is in overall resonance state.
5. as claimed in claim 1 based on the pure titanium solid microneedles forming technology that ultrasonic vibration is auxiliary, it is characterized in that: pretreatment described in step C is that Titanium board is obtained equiax crystal titanium plate through full annealing recrystallization, then process and be of a size of 2mm × 2mm ~ 3mm × 3mm, roughness grade is the Titanium board of 1.6 ~ 6.3, and clean up.
6., as claimed in claim 5 based on the pure titanium solid microneedles forming technology that ultrasonic vibration is auxiliary, it is characterized in that: described in clean up be clean with alcohol washes.
7., as claimed in claim 1 based on the pure titanium solid microneedles forming technology that ultrasonic vibration is auxiliary, it is characterized in that: the diameter of the pure titanium solid microneedles prepared in step D is 100 μm, and length is 100 ~ 200 μm.
8., as claimed in claim 1 based on the pure titanium solid microneedles forming technology that ultrasonic vibration is auxiliary, it is characterized in that: the ultrasound parameter described in step D is: resonant frequency 20KHz, power 300 ~ 1000W.
9. as claimed in claim 1 based on the pure titanium solid microneedles forming technology that ultrasonic vibration is auxiliary, it is characterized in that: it is exerted pressure to mould by omnipotent mechanics machine that the pier described in step D squeezes, and pressure is 2 ~ 10KN.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101678584A (en) * | 2007-06-20 | 2010-03-24 | 3M创新有限公司 | Ultrasonic injection molding on a web |
| WO2010117602A2 (en) * | 2009-04-10 | 2010-10-14 | 3M Innovative Properties Company | Methods of making hollow microneedle arrays and articles and uses therefrom |
| CN102836936A (en) * | 2012-08-30 | 2012-12-26 | 上海交通大学 | Preparation method of solid titanium microneedle for cutaneous penetration |
| CN103691792A (en) * | 2013-12-18 | 2014-04-02 | 山东科技大学 | Ultrasonic-based medium-high carbon steel fine blanking forming device |
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2015
- 2015-05-21 CN CN201510263694.2A patent/CN104959502A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101678584A (en) * | 2007-06-20 | 2010-03-24 | 3M创新有限公司 | Ultrasonic injection molding on a web |
| WO2010117602A2 (en) * | 2009-04-10 | 2010-10-14 | 3M Innovative Properties Company | Methods of making hollow microneedle arrays and articles and uses therefrom |
| CN102836936A (en) * | 2012-08-30 | 2012-12-26 | 上海交通大学 | Preparation method of solid titanium microneedle for cutaneous penetration |
| CN103691792A (en) * | 2013-12-18 | 2014-04-02 | 山东科技大学 | Ultrasonic-based medium-high carbon steel fine blanking forming device |
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Application publication date: 20151007 |