CN104958621A - Anti-neoplastic traditional Chinese medicine composition and preparation method thereof - Google Patents

Abstract

The invention relates to the technical filed of traditional Chinese medicine, in particular to an anti-neoplastic traditional Chinese medicine composition and a preparation method thereof. The traditional Chinese medicine composition comprises, by weight, 34-38 parts of sophoridine, 30-33 parts of black sesame, 36-38 parts of Chinese yam, 34-35 parts of coix seeds, 45-48 parts of hawthorn fruits, 8-30 parts of sea-tent, 3-4 parts of mulberries and 9-34 parts of phaseolus calcaratus. The anti-neoplastic traditional Chinese medicine composition is developed through selection of a large number of drugs and a certain clinical experiments, sophoridine seedlings have functions of attacking variant cells in a targeting mode and protecting normal cells, so the sophoridine serves as a chief herb, a large number of anti-neoplastic drugs and insect drugs are supplemented, and the purposes of clearing away heat and toxic materials, reducing phlegm and resolving masses, promoting circulation and removing stasis and tumor inhibition are achieved.

Description

A kind of antineoplastic Chinese medicine composition and preparation method thereof

Technical field

The present invention relates to technical field of Chinese medicines, be specifically related to a kind of antineoplastic Chinese medicine composition and preparation method thereof.

Background technology

Tumor is a kind of genopathy in essence, various environment cause DNA to damage with the carcinogenic factor of heredity with collaborative or sequential mode, thus activate proto-oncogene or deactivation tumor suppressor gene, add the change of apoptosis gene or DNA-repair gene, then cause the exception of expression, target cell is transformed.The cell that is converted is first many in Clonal hypertrophy, through a very long multistage evolution process, and the wherein relatively unconfined amplification of individual clone, pass through addition mutation, optionally form the sub-clone with different characteristics, thus obtain the ability of invasion and m etastasis, form malignant tumor.More existing Therapeutic Method other positions to the health of people to tumor damage, and tumor makes the psychology of people change a lot, and existing medicine is very large to the side effect of human body.

Tumor is the disease of serious harm human health and life." talk cancer complexion changed " and indicate the terror psychology of the mankind for cancer straight from the shoulder.At present, also there is no a kind of Therapeutic Method that can effect a radical cure tumor in the world, radical cure tumor be numerous medical personnels and medicine researcher arduous and in large task, be also their maximum objective of the struggle.Current, the Therapeutic Method of tumor has two kinds: Chinese traditional treatment and western medical treatment.Western medical treatment Main Means is ocal resection focus, and cancerous cell cannot be removed, and by radiotherapy, chemotherapy and targeted therapy regrettably, western medical treatment method can only extend the life of patient, does not but reach the effect of radical cure.Global medical personnel places on the Chinese medicine of China the hope of radical cure tumor, thirsts for the Chinese medicine of extensive knowledge and profound scholarship Therapeutic Method of " one thing conquers another " and works miracle.

Summary of the invention

Antineoplastic Chinese medicine composition of the present invention, is made up of the raw material of following parts by weight: sophoridine 34 ~ 38 parts, Semen Sesami Nigrum 30 ~ 33 parts, Rhizoma Dioscoreae 36 ~ 38 parts, Semen Coicis 34 ~ 35 parts, Fructus Crataegi 45 ~ 48 parts, Thallus Laminariae (Thallus Eckloniae) 8 ~ 30 parts, Fructus Mori 3 ~ 4 parts, Semen Phaseoli 9 ~ 34.

Preferably, this Chinese medicine composition is by the raw material of following parts by weight: sophoridine 35 parts, Semen Sesami Nigrum 30 parts, Rhizoma Dioscoreae 36 parts, Semen Coicis 34 parts, Fructus Crataegi 46 parts, Thallus Laminariae (Thallus Eckloniae) 9 parts, Fructus Mori 3 parts, Semen Phaseoli 34 parts are made.

Prepare the method for this antitumor drug, comprise the following steps:

A, the sophoridine getting affiliated weight fraction, Rhizoma Dioscoreae make 40 ~ 30 order powder; Then add the water of 30 times of weight, decoct 4 times, each 3 hours, collecting decoction, concentrated, namely vacuum drying obtains extract A;

B, the Semen Sesami Nigrum of getting affiliated weight fraction, Semen Coicis, Fructus Crataegi make 40 ~ 30 order powder, add 34 times of weight dehydrated alcohol, reflux, extract, 3 times, each 4 hours, merge extractive liquid, and concentrated, namely vacuum drying obtains extract B;

C, the Thallus Laminariae (Thallus Eckloniae) of described parts by weight, Fructus Mori, Semen Phaseoli are made the above powder of 300 order; Same extract A, extract B mix homogeneously.

Effective ingredient in invention comprises:

Sophoridine belongs to natural product, and toxic and side effects is less, bioavailability is high, stable in properties, has good Clinical practice and is worth.But, not yet have about the play-by-play of sophoridine in treatment tumor.After sophoridine intravenous injection, blood pressure can be caused to fall after rising; Excitation is had to the isolated heart of homoiothermy, cold blooded animal; Contraction can be caused to the tip and visceral vessel.From Sophora Alopecuroides L., extract this product of gained, through clinical observation therapeutic equivalence, effect is slight.Extracorporeal bacteria inhibitor test proves, all has inhibitory action to 35 kinds of dysentery bacterial strains such as will Hayes, Song Nei Shi, Fu Shi, this Mi Shi.

Rhizoma Dioscoreae: property is sweet flat, returns spleen, lung, kidney channel.Its function: strengthening the spleen and tonifying the lung reinforces the kidney beneficial smart, can treat diarrhea due to hypofunction of the spleen, chronic dysentery, cough due to consumptive disease, frequency of micturition, leukorrhagia seminal emission etc.Rhizoma Dioscoreae energy kidney tonifying, essence replenishing, essence foot is then cloudy strong, and the bright ear of order is clever, treatment diabetes.

Poria: property is sweet, light, flat, GUIXIN, lung, spleen, kidney channel.Its function promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.

Semen Coicis: property is sweet light cool, enters spleen, lung, kidney channel.Function: strengthening the spleen and tonifying the lung, clearing away heat-damp and promoting diuresis, controls verruca plana, has inhibitory action to cancerous cell.There is blood sugar reducing function.

Fructus Crataegi: enter spleen, lung, Liver Channel, nature and flavor acid, sweet tepor.Its function, help digestion long-pending (meat amass), dissipating blood stasis blood, phlegm retention, lumbago xenon, puerperal abdonimal pain, lochiorrhea, children's's infantile dyspepsia, controls acute bacillary dysentery, reduces cholesterol, and its floral leaf reduces blood pressure, heart tonifying, coronary vasodilation.

Thallus Laminariae (Thallus Eckloniae): property is salty-cold, to thyroid effect, has hypotensive effect, has antiasthmatic effect effect, has removing blood fat, has antitumor action, and harnessing the river, swollen, testis is swollen, the capable water of softening the hard mass, treatment scrofula, the cancer of the esophagus.

Fructus Mori: enter liver, kidney channel, property is sweet cold, function, the liver and the kidney tonifying, and relieve dizziness, high fever, infantile convulsions, epilepsy, etc. taste liquid, treating the liver, kidney yin are lost, constipation of quenching one's thirst, the dark tinnitus of order, scrofula, articular instability, antiabortive effect, habitual constipation.

Semen Phaseoli: the sweet acid of property is put down, and enters heart small intestine meridian, function: diuretic dehumidifies, and blood evacuation of pus, and subduing swelling and detoxicating, can control mumps, cirrhotic ascites.

Compare with existing tumor, this group prescription has obvious the liver and the kidney tonifying, spleen invigorating, antioxidation, strengthens autoimmunity, and by regulating body autoimmunity, health invigorating, reaches strengthening vital QI to eliminate pathogenic factors, prevention object of recovering.

Detailed description of the invention

The invention will be further described for embodiment plan given below; but can not be interpreted as it is limiting the scope of the invention; those skilled in the art to nonessential improvement and adjustment more of the present invention, still belong to protection scope of the present invention according to content of the present invention.

Embodiment 1

A, get sophoridine 35 grams, Rhizoma Dioscoreae 36 grams, make 40 ~ 30 order powder, then mix homogeneously respectively; Add the water of 30 times of weight, decoct 4 times, each 3 hours, collecting decoction, concentrated, namely vacuum drying obtains extract A;

B, get Semen Sesami Nigrum 30 grams, Semen Coicis 34 grams, Fructus Crataegi 46 restrain into 40 ~ 30 order powder, then mix homogeneously; Add 34 times of weight dehydrated alcohol, reflux, extract, 3 times, each 4 hours, merge extractive liquid, concentrated, namely vacuum drying obtains extract B;

C, get Thallus Laminariae (Thallus Eckloniae) 9 grams, Fructus Mori 3 grams, Semen Phaseoli 34 restrain into the above powder of 300 order; Same extract A, extract B mix homogeneously.

Embodiment 2:

A, get sophoridine 34 grams, Rhizoma Dioscoreae 36 grams, make 40 ~ 30 order powder, then mix homogeneously respectively; Add the water of 30 times of weight, decoct 4 times, each 3 hours, collecting decoction, concentrated, namely vacuum drying obtains extract A;

B, get Semen Sesami Nigrum 30 grams, Semen Coicis 34 grams, Fructus Crataegi 45 restrain into 40 ~ 30 order powder, then mix homogeneously; Add 34 times of weight dehydrated alcohol, reflux, extract, 3 times, each 4 hours, merge extractive liquid, concentrated, namely vacuum drying obtains extract B;

C, get Thallus Laminariae (Thallus Eckloniae) 8 grams, Fructus Mori 3 grams, Semen Phaseoli 9 restrain into the above powder of 300 order; Same extract A, extract B mix homogeneously.

Embodiment 3:

A, get sophoridine 38 grams, Rhizoma Dioscoreae 38 grams, make 40 ~ 30 order powder, then mix homogeneously respectively; Add the water of 30 times of weight, decoct 4 times, each 3 hours, collecting decoction, concentrated, namely vacuum drying obtains extract A;

B, get Semen Sesami Nigrum 33 grams, Semen Coicis 35 grams, Fructus Crataegi 48 restrain into 40 ~ 30 order powder, then mix homogeneously; Add 34 times of weight dehydrated alcohol, reflux, extract, 3 times, each 4 hours, merge extractive liquid, concentrated, namely vacuum drying obtains extract B;

C, get Thallus Laminariae (Thallus Eckloniae) 30 grams, Fructus Mori 4 grams, Semen Phaseoli 34 restrain into the above powder of 300 order; Same extract A, extract B mix homogeneously.

Claims (3)

1. an antineoplastic Chinese medicine composition, is characterized in that: this Chinese medicine composition is by the raw material of following parts by weight: sophoridine 34 ~ 38 parts, Semen Sesami Nigrum 30 ~ 33 parts, Rhizoma Dioscoreae 36 ~ 38 parts, Semen Coicis 34 ~ 35 parts, Fructus Crataegi 45 ~ 48 parts, Thallus Laminariae (Thallus Eckloniae) 8 ~ 30 parts, Fructus Mori 3 ~ 4 parts, Semen Phaseoli 9 ~ 34 parts are made.

2. antineoplastic Chinese medicine composition according to claim 1, is characterized in that: this Chinese medicine composition is by the raw material of following parts by weight: sophoridine 35 parts, Semen Sesami Nigrum 30 parts, Rhizoma Dioscoreae 36 parts, Semen Coicis 34 parts, Fructus Crataegi 46 parts, Thallus Laminariae (Thallus Eckloniae) 9 parts, Fructus Mori 3 parts, Semen Phaseoli 34 parts are made.

3. prepare a method for antineoplastic Chinese medicine composition described in claim 1, it is characterized in that: comprise the following steps:

A, the sophoridine getting described weight fraction, Rhizoma Dioscoreae make 40 ~ 30 order powder; Then add the water of 30 times of weight, decoct 4 times, each 3 hours, collecting decoction, concentrated, namely vacuum drying obtains extract A;

B, the Semen Sesami Nigrum of getting described weight fraction, Semen Coicis, Fructus Crataegi make 40 ~ 30 order powder, add 34 times of weight dehydrated alcohol, reflux, extract, 3 times, each 4 hours, merge extractive liquid, and concentrated, namely vacuum drying obtains extract B;

C, the Thallus Laminariae (Thallus Eckloniae) of described parts by weight, Fructus Mori, Semen Phaseoli are made the above powder of 300 order; Same extract A, extract B mix homogeneously.