CN104945887A - Preparation method of composite material used for artificial hearts - Google Patents
Preparation method of composite material used for artificial hearts Download PDFInfo
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- CN104945887A CN104945887A CN201510384408.8A CN201510384408A CN104945887A CN 104945887 A CN104945887 A CN 104945887A CN 201510384408 A CN201510384408 A CN 201510384408A CN 104945887 A CN104945887 A CN 104945887A
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Abstract
The invention discloses a preparation method of a composite material used for artificial hearts. The method comprises the following steps: I. weighing all the components in parts by weight; II. mixing all the components in a mixing stirrer uniformly and then internally mixing the components to obtain a composite material; III. molding the composite material in a mold by heating, then demolding the molded product after cooling the product, then cutting, and finally sterilizing and packaging, thus obtaining the composite material. The preparation method is shorter in flow, simple to operate and low in cost, is environment-friendly and has high economic benefits. The material used for artificial hearts, which is prepared by the preparation method, has better bioactivity, biocompatibility and osteoconductivity than existing materials, and has high strength and good mechanical properties.
Description
Technical field
The invention belongs to polymeric material field, relate to a kind of preparation method of artificial heart matrix material.
Technical background
Plastics to obtain at medical field with its excellent character, reliably performance, easily moulding process and apply more and more widely, make plastic material prepare medical treatment product and have development prospect.First plastics have good physical and mechanical property and chemical stability, compare and are adapted at medical field use; Secondly macromolecular material abundance, cheap, is applicable to making disposable medical article, avoids traditional material goods have to repeatedly use sterilization and the cross infection caused problem because price is high; And plastics have or are easier to modification and obtain good histocompatibility, blood compatibility goods; Also have plastic working convenient, cost of manufacture is low, is applicable to multiple molding mode, is convenient to be processed into complicated shape and development of new medical product.
From the thirties in 20th century, people use synthesized polymer material first---and since the kidney machine that xylonite film is made as dialysis membrane is applied to clinical succeeding, macromolecular material is progressively substituting conventional inorganic material if metal (or alloy), glass, pottery, phosphatic rock etc. are for the preparation of medical treatment product.1949, first the U.S. delivered the prospect paper of medical polymer, and first time describes and utilizes polymethylmethacrylate (PMMA) as the skull bone of people, joint and femur, utilizes tynex as the clinical application situation of operating sutures.The 1950's, organosilicon polymer is used to medical field, and the range of application of artificial organs is expanded greatly, comprises organ and substitutes and many aspects such as lift face.In the 1950's, large quantities of artificial organs is tried out in clinical, as artificial urethra (nineteen fifty), artificial blood vessel's (nineteen fifty-one), artificial esophagus's (nineteen fifty-one), heart valve prosthesis (nineteen fifty-two), artificial heart-lung (nineteen fifty-three), artificial heart-lung (nineteen fifty-three), joint prosthesis (1954) and artificial liver (1958) etc.The sixties in 20th century, medical macromolecular materials start to enter a brand-new developing period.
At present, plastics in the recycle system are mainly artificial heart, and the plastics mainly polyethers ammonia vinegar class material of artificial heart application, have good springiness, anti-aging, histocompatibility and blood compatibility good, product performance regulate the advantages such as change by molecular designing.Prepare artificial heart and mainly use aliphatic polyether ammonia vinegar at present, its developing direction is by its modification, and on molecular chain, grafted silicone rubber and VITAMIN e etc. are to improve its biocompatibility further.The development of and low resistance strong to miniaturization, wearing quality along with artificial heart, likely as artificial cardiac pacemaker, be able to widespread use in the future, plastics will play larger effect at that time.Due to contact with liquid or and human contact, the basic demand of medical grade plastic materials has chemical stability and biological safety.In simple terms, the moiety in plastic material can not be separated out and enter liquid or human body, can not cause toxicity and the damage of histoorgan, is nontoxic to human body.For improving blood compatibility, the histocompatibility of goods, need the modifying surface to goods.The plastic tool anti-infection property getting involved life-time service in human body is one of research and development direction of current medical grade plastic materials.In sum, a kind of consistency is high, security is high medical artificial heart plastic material is badly in need of providing to be this area technical problem urgently to be resolved hurrily.
Summary of the invention
The object of the invention is to for the deficiencies in the prior art, a kind of preparation method of artificial heart matrix material is provided.
The object of the invention is to be achieved through the following technical solutions: a kind of preparation method of artificial heart matrix material, said method comprising the steps of: step one, urethane 50-70 part is taken according to weight part, polyvinylpyrrolidone 2-5 part, EVA 25-40 part, chitosan 12-18 part, magnesium borate crystal whisker 2-7 part, two maleinamic acid 6-12 part, divinyl tetramine 2-6 part, Yelkin TTS 4-6 part, two maleinamic acid 6-12 part, sodium alginate 3-12 part, trichloroisocyanuric acid 0.6-1 part, manganous sulfate 1-1.5 part, clorafin 8-15 part, calcium lignin sulphonate 0.8-2 part, glycerol 3-8 part, stearic acid 4-8 part, coupling agent 3-5 part and toughner 3-5 part, step 2, each component is mixed in mixing and blending machine after, carry out banburying, obtain matrix material, step 3, by the hot briquetting in a mold of above-mentioned matrix material, then by the demoulding after the product cooling after shaping, then through machining, terminal disinfection is packed, and to obtain final product.
Described coupling agent adopts silane coupling agent.
Described toughner is grafting maleic anhydride with ethylene propylene terpolymer.
Described Heating temperature is 115 ~ 130 DEG C.
Described banburying temperature is 60 ~ 70 DEG C, and the banburying time is 30 ~ 60 minutes.
The present invention has following beneficial effect: preparation method's flow process of the present invention is shorter, simple to operate, and cost is low, environmentally friendly, high financial profit.One provided by the invention prepares artificial heart MATERIALS METHODS, and this material has excellent biological activity, biocompatibility and osteoconductive, be all better than current material, and its intensity is high, good mechanical property.
Embodiment
embodiment 1
A preparation method for artificial heart matrix material, preparation method comprises the following steps: step one, take urethane 50 parts, polyvinylpyrrolidone 2 parts, EVA 25 parts, chitosan 12 parts, magnesium borate crystal whisker 2 parts, two maleinamic acid 6 parts, divinyl tetramine 2 parts, 4 parts, Yelkin TTS, two maleinamic acid 6 parts, sodium alginate 3 parts, trichloroisocyanuric acid 0.6 part, manganous sulfate 1 part, clorafin 8 parts, calcium lignin sulphonate 0.8 part, glycerol 3 parts, stearic acid 4 parts, coupling agent 3 parts and toughner 3 parts according to weight part; Step 2, each component is mixed in mixing and blending machine after, carry out banburying, obtain matrix material; Step 3, by the hot briquetting in a mold of above-mentioned matrix material, then by the demoulding after the product cooling after shaping, then through machining, terminal disinfection is packed, and to obtain final product.
Described coupling agent adopts silane coupling agent.
Described toughner is grafting maleic anhydride with ethylene propylene terpolymer.
Described Heating temperature is 115 ~ 130 DEG C.
Described banburying temperature is 60 ~ 70 DEG C, and the banburying time is 30 ~ 60 minutes.
embodiment 2
A preparation method for artificial heart matrix material, preparation method comprises the following steps: step one, take urethane 70 parts, polyvinylpyrrolidone 5 parts, EVA 40 parts, chitosan 18 parts, magnesium borate crystal whisker 7 parts, two maleinamic acid 12 parts, divinyl tetramine 6 parts, 6 parts, Yelkin TTS, two maleinamic acid 12 parts, sodium alginate 12 parts, trichloroisocyanuric acid 1 part, manganous sulfate 1.5 parts, clorafin 15 parts, calcium lignin sulphonate 2 parts, glycerol 8 parts, stearic acid 8 parts, coupling agent 5 parts and toughner 5 parts according to weight part; Step 2, each component is mixed in mixing and blending machine after, carry out banburying, obtain matrix material; Step 3, by the hot briquetting in a mold of above-mentioned matrix material, then by the demoulding after the product cooling after shaping, then through machining, terminal disinfection is packed, and to obtain final product.
Described coupling agent adopts silane coupling agent.
Described toughner is grafting maleic anhydride with ethylene propylene terpolymer.
Described Heating temperature is 115 ~ 130 DEG C.
Described banburying temperature is 60 ~ 70 DEG C, and the banburying time is 30 ~ 60 minutes.
embodiment 3
A preparation method for artificial heart matrix material, preparation method comprises the following steps: step one, take urethane 60 parts, polyvinylpyrrolidone 3 parts, EVA 30 parts, chitosan 15 parts, magnesium borate crystal whisker 4 parts, two maleinamic acid 8 parts, divinyl tetramine 4 parts, 5 parts, Yelkin TTS, two maleinamic acid 9 parts, sodium alginate 7 parts, trichloroisocyanuric acid 0.8 part, manganous sulfate 1.3 parts, clorafin 12 parts, calcium lignin sulphonate 1.6 parts, glycerol 5 parts, stearic acid 6 parts, coupling agent 4 parts and toughner 4 parts according to weight part; Step 2, each component is mixed in mixing and blending machine after, carry out banburying, obtain matrix material; Step 3, by the hot briquetting in a mold of above-mentioned matrix material, then by the demoulding after the product cooling after shaping, then through machining, terminal disinfection is packed, and to obtain final product.
Described coupling agent adopts silane coupling agent.
Described toughner is grafting maleic anhydride with ethylene propylene terpolymer.
Described Heating temperature is 115 ~ 130 DEG C.
Described banburying temperature is 60 ~ 70 DEG C, and the banburying time is 30 ~ 60 minutes.
The above, it is only preferred embodiment of the present invention, not any pro forma restriction is done to the present invention, although the present invention discloses as above with preferred embodiment, but and be not used to limit the present invention, any those skilled in the art, do not departing within the scope of technical solution of the present invention, make a little change when the technology contents of above-mentioned announcement can be utilized or be modified to the Equivalent embodiments of equivalent variations, in every case be the content not departing from technical solution of the present invention, according to any simple modification that technical spirit of the present invention is done above embodiment, equivalent variations and modification, all still belong in the scope of technical solution of the present invention.
Claims (5)
1. the preparation method of an artificial heart matrix material, it is characterized in that, said method comprising the steps of: step one, urethane 50-70 part is taken according to weight part, polyvinylpyrrolidone 2-5 part, EVA 25-40 part, chitosan 12-18 part, magnesium borate crystal whisker 2-7 part, two maleinamic acid 6-12 part, divinyl tetramine 2-6 part, Yelkin TTS 4-6 part, two maleinamic acid 6-12 part, sodium alginate 3-12 part, trichloroisocyanuric acid 0.6-1 part, manganous sulfate 1-1.5 part, clorafin 8-15 part, calcium lignin sulphonate 0.8-2 part, glycerol 3-8 part, stearic acid 4-8 part, coupling agent 3-5 part and toughner 3-5 part, step 2, each component is mixed in mixing and blending machine after, carry out banburying, obtain matrix material, step 3, by the hot briquetting in a mold of above-mentioned matrix material, then by the demoulding after the product cooling after shaping, then through machining, terminal disinfection is packed, and to obtain final product.
2. the preparation method of a kind of artificial heart matrix material according to claim 1, is characterized in that, described coupling agent adopts silane coupling agent.
3. the preparation method of a kind of artificial heart matrix material according to claim 1, it is characterized in that, described toughner is grafting maleic anhydride with ethylene propylene terpolymer.
4. the preparation method of a kind of artificial heart matrix material according to claim 1, is characterized in that, described Heating temperature is 115 ~ 130 DEG C.
5. the preparation method of a kind of artificial heart matrix material according to claim 1, is characterized in that, described banburying temperature is 60 ~ 70 DEG C, and the banburying time is 30 ~ 60 minutes.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201510384408.8A CN104945887A (en) | 2015-06-30 | 2015-06-30 | Preparation method of composite material used for artificial hearts |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510384408.8A CN104945887A (en) | 2015-06-30 | 2015-06-30 | Preparation method of composite material used for artificial hearts |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105860154A (en) * | 2016-05-06 | 2016-08-17 | 王泽陆 | Chitosan/polyurethane composite material and method for preparing same |
| CN107343966A (en) * | 2017-05-31 | 2017-11-14 | 苏州蔻美新材料有限公司 | A kind of preparation method of artificial heart nano meter biomaterial |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1791437A (en) * | 2003-05-16 | 2006-06-21 | 布卢薄膜有限责任公司 | Medical implants comprising biocompatible coatings |
| CN104474588A (en) * | 2014-11-25 | 2015-04-01 | 苏州市贝克生物科技有限公司 | Polyurethane medical antibacterial material and preparation method thereof |
-
2015
- 2015-06-30 CN CN201510384408.8A patent/CN104945887A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1791437A (en) * | 2003-05-16 | 2006-06-21 | 布卢薄膜有限责任公司 | Medical implants comprising biocompatible coatings |
| CN104474588A (en) * | 2014-11-25 | 2015-04-01 | 苏州市贝克生物科技有限公司 | Polyurethane medical antibacterial material and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105860154A (en) * | 2016-05-06 | 2016-08-17 | 王泽陆 | Chitosan/polyurethane composite material and method for preparing same |
| CN107343966A (en) * | 2017-05-31 | 2017-11-14 | 苏州蔻美新材料有限公司 | A kind of preparation method of artificial heart nano meter biomaterial |
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Application publication date: 20150930 |