CN104940986B - It is a kind of to be applied to intracutaneous suture and preparation method thereof - Google Patents
It is a kind of to be applied to intracutaneous suture and preparation method thereof Download PDFInfo
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- CN104940986B CN104940986B CN201510308466.2A CN201510308466A CN104940986B CN 104940986 B CN104940986 B CN 104940986B CN 201510308466 A CN201510308466 A CN 201510308466A CN 104940986 B CN104940986 B CN 104940986B
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Abstract
It is applied to intracutaneous suture and preparation method thereof the invention discloses a kind of, the suture is made up of each component of following mass parts：45 63 parts of polypropylene, 17 29 parts of butanediol, 9 18 parts of glycerine, 5 21 parts of maleic anhydride, 2 11 parts of ammonium dihydrogen phosphate, 13 27 parts of PLA, 2 10 parts of PGA, 4 18 parts of 2,6 three-level butyl, 4 methylphenol.Suture produced by the present invention improves tensile strength and elongation, reduces frictional force, it is adaptable to intradermal suture, can be widely used for clinical treatment.
Description
Technical field
The invention belongs to suture field, and in particular to a kind of to be applied to intracutaneous suture and preparation method thereof.
Background technology
Operation suture thread refers among surgical operation, or wound disposal is central, for hemostasis by ligation, Suture hemostasis
And the distinct line of tissue apposition, it generally can be divided into absorbable thread and the major class of nonabsorable line two, wherein absorbable suture root
It is divided into again according to material and degree of absorption are different：Catgut, chemical synthesis line（PGA）, pure-natural collagen suture.
The requirement of operation suture thread have it is following some：1 can keep enough intensity during Wound healing, should also energy
Enough elongations bounce back with wound to adapt to wound oedema and are retracted into original length；It can voluntarily degrade again after 2 Wound healings
Absorb, no longer leave foreign matter；3 do not produce inflammation；4 nonirritant and carcinogenicities；5 the processing such as are easy to dye, sterilize, sterilize；6 can
Form knot securely；7 is easy to make, cheap, can largely produce.
Frictional force between suture and tissue determines whether suture facilitates penetration of tissue, the low suture energy of frictional force
It is enough easily to slip over tissue, therefore often be used to do intradermal suture.But existing intradermal suture line is in reduction frictional force
Meanwhile, tensile strength and elongation also decrease, and have impact on the effect of suture, are insufficient for the requirement of clinical treatment.
The content of the invention
In order to overcome above the deficiencies in the prior art, intracutaneous suture and its preparation are applied to the invention provides a kind of
Method, can improve tensile strength and elongation, reduce frictional force, it is adaptable to intradermal suture, can be widely used for clinical treatment.
The technical solution adopted by the present invention is：It is a kind of to be applied to intracutaneous suture, it is grouped by each group of following mass parts
Into：It is 45-63 parts of polypropylene, 17-29 parts of butanediol, 9-18 parts of glycerine, 5-21 parts of maleic anhydride, 2-11 parts of ammonium dihydrogen phosphate, poly-
13-27 parts of lactic acid, 2-10 parts of PGA, 4-18 parts of 2,6- three-level butyl -4- methylphenols.
It is preferred that, it is a kind of to be applied to intracutaneous suture, it is made up of each component of following mass parts：48-59 parts of polypropylene,
21-27 parts of butanediol, 11-16 parts of glycerine, 7-15 parts of maleic anhydride, 4-9 parts of ammonium dihydrogen phosphate, 15-23 parts of PLA, poly- second are handed over
4-8 parts of ester, 5-12 parts of 2,6- three-level butyl -4- methylphenols.
It is furthermore preferred that a kind of be applied to intracutaneous suture, it is made up of each component of following mass parts：53 parts of polypropylene,
26 parts of butanediol, 14 parts of glycerine, 12 parts of maleic anhydride, 7 parts of ammonium dihydrogen phosphate, 19 parts of PLA, 6 parts of PGA, 2,6- tri-
9 parts of level butyl -4- methylphenols.
A kind of preparation method suitable for intracutaneous suture, comprises the following steps：
（1）By above-mentioned mass parts, polypropylene is placed in reactor, is melted under the conditions of 160-210 DEG C, adds fourth two
Alcohol, glycerine, maleic anhydride, ammonium dihydrogen phosphate, PLA, PGA and 2,6- three-level butyl -4- methylphenols, 80-100 DEG C
Under the conditions of ultrasound 10-20min, obtain compound；
（2）To step（1）Send into double screw extruder and granulate in gained compound, cool down, dry, mother is obtained after cutting
Grain；
（3）By step（2）Gained master batch is heated to 120-150 DEG C, by spinneret formation primary filament, then in 50-80
DEG C water-bath in carry out succeeding stretch, produce and described be applied to intracutaneous suture.
Above-mentioned steps（2）Middle double screw extruder temperature is 210-260 DEG C, and screw speed is 700-1000r/min.
Beneficial effect：Suture tensile strength produced by the present invention is between 1.68-1.83 kg/cm, and elongation exists
Between 28.5-31.7%, frictional force be 6.56-7.32 cN, by the synergy between component, can improve tensile strength and
Elongation, reduces frictional force, it is adaptable to intradermal suture, can be widely used for clinical treatment.
Embodiment
Embodiment 1
It is a kind of to be applied to intracutaneous suture, it is made up of each component of following mass parts：45 parts of polypropylene, butanediol 17
Part, 9 parts of glycerine, 5 parts of maleic anhydride, 2 parts of ammonium dihydrogen phosphate, 13 parts of PLA, 2 parts of PGA, 2,6- three-level butyl -4- first
4 parts of base phenol.
Preparation method：
（1）By above-mentioned mass parts, polypropylene is placed in reactor, is melted under the conditions of 160 DEG C, adds butanediol, sweet
Oil, maleic anhydride, ammonium dihydrogen phosphate, PLA, PGA and 2,6- three-level butyl -4- methylphenols, surpass under the conditions of 80 DEG C
Sound 10min, obtains compound；
（2）To step（1）Send into double screw extruder and granulate in gained compound, cool down, dry, mother is obtained after cutting
Grain, wherein double screw extruder temperature are 210 DEG C, and screw speed is 700r/min；
（3）By step（2）Gained master batch is heated to 120 DEG C, by spinneret formation primary filament, then in 50 DEG C of water-bath
Middle carry out succeeding stretch, is produced described suitable for intracutaneous suture.
Embodiment 2
It is a kind of to be applied to intracutaneous suture, it is made up of each component of following mass parts：63 parts of polypropylene, butanediol 29
Part, 18 parts of glycerine, 21 parts of maleic anhydride, 11 parts of ammonium dihydrogen phosphate, 27 parts of PLA, 10 parts of PGA, 2,6- three-levels butyl-
18 parts of 4- methylphenols.
Preparation method：
（1）By above-mentioned mass parts, polypropylene is placed in reactor, is melted under the conditions of 210 DEG C, adds butanediol, sweet
Oil, maleic anhydride, ammonium dihydrogen phosphate, PLA, PGA and 2,6- three-level butyl -4- methylphenols, under the conditions of 100 DEG C
Ultrasonic 20min, obtains compound；
（2）To step（1）Send into double screw extruder and granulate in gained compound, cool down, dry, mother is obtained after cutting
Grain, wherein double screw extruder temperature are 260 DEG C, and screw speed is 1000r/min；
（3）By step（2）Gained master batch is heated to 150 DEG C, by spinneret formation primary filament, then in 80 DEG C of water-bath
Middle carry out succeeding stretch, is produced described suitable for intracutaneous suture.
Embodiment 3
It is a kind of to be applied to intracutaneous suture, it is made up of each component of following mass parts：48 parts of polypropylene, butanediol 21
Part, 11 parts of glycerine, 7 parts of maleic anhydride, 4 parts of ammonium dihydrogen phosphate, 15 parts of PLA, 4 parts of PGA, 2,6- three-level butyl -4-
5 parts of methylphenol.
Preparation method：
（1）By above-mentioned mass parts, polypropylene is placed in reactor, is melted under the conditions of 170 DEG C, adds butanediol, sweet
Oil, maleic anhydride, ammonium dihydrogen phosphate, PLA, PGA and 2,6- three-level butyl -4- methylphenols, surpass under the conditions of 85 DEG C
Sound 12min, obtains compound；
（2）To step（1）Send into double screw extruder and granulate in gained compound, cool down, dry, mother is obtained after cutting
Grain, wherein double screw extruder temperature are 220 DEG C, and screw speed is 800r/min；
（3）By step（2）Gained master batch is heated to 130 DEG C, by spinneret formation primary filament, then in 60 DEG C of water-bath
Middle carry out succeeding stretch, is produced described suitable for intracutaneous suture.
Embodiment 4
It is a kind of to be applied to intracutaneous suture, it is made up of each component of following mass parts：59 parts of polypropylene, butanediol 27
Part, 16 parts of glycerine, 15 parts of maleic anhydride, 9 parts of ammonium dihydrogen phosphate, 23 parts of PLA, 8 parts of PGA, 2,6- three-level butyl -4-
12 parts of methylphenol.
Preparation method：
（1）By above-mentioned mass parts, polypropylene is placed in reactor, is melted under the conditions of 200 DEG C, adds butanediol, sweet
Oil, maleic anhydride, ammonium dihydrogen phosphate, PLA, PGA and 2,6- three-level butyl -4- methylphenols, surpass under the conditions of 90 DEG C
Sound 18min, obtains compound；
（2）To step（1）Send into double screw extruder and granulate in gained compound, cool down, dry, mother is obtained after cutting
Grain, wherein double screw extruder temperature are 250 DEG C, and screw speed is 900r/min；
（3）By step（2）Gained master batch is heated to 140 DEG C, by spinneret formation primary filament, then in 70 DEG C of water-bath
Middle carry out succeeding stretch, is produced described suitable for intracutaneous suture.
Embodiment 5
It is a kind of to be applied to intracutaneous suture, it is made up of each component of following mass parts：53 parts of polypropylene, butanediol 26
Part, 14 parts of glycerine, 12 parts of maleic anhydride, 7 parts of ammonium dihydrogen phosphate, 19 parts of PLA, 6 parts of PGA, 2,6- three-level butyl -4-
9 parts of methylphenol.
Preparation method：
（1）By above-mentioned mass parts, polypropylene is placed in reactor, is melted under the conditions of 180 DEG C, adds butanediol, sweet
Oil, maleic anhydride, ammonium dihydrogen phosphate, PLA, PGA and 2,6- three-level butyl -4- methylphenols, surpass under the conditions of 90 DEG C
Sound 15min, obtains compound；
（2）To step（1）Send into double screw extruder and granulate in gained compound, cool down, dry, mother is obtained after cutting
Grain, wherein double screw extruder temperature are 230 DEG C, and screw speed is 900r/min；
（3）By step（2）Gained master batch is heated to 130 DEG C, by spinneret formation primary filament, then in 70 DEG C of water-bath
Middle carry out succeeding stretch, is produced described suitable for intracutaneous suture.
Comparative example 1
Difference with embodiment 5 is to be not added with PGA.
It is a kind of to be applied to intracutaneous suture, it is made up of each component of following mass parts：53 parts of polypropylene, butanediol 26
Part, 14 parts of glycerine, 12 parts of maleic anhydride, 7 parts of ammonium dihydrogen phosphate, 19 parts of PLA, 9 parts of 2,6- three-level butyl -4- methylphenols.
Preparation method：
（1）By above-mentioned mass parts, polypropylene is placed in reactor, is melted under the conditions of 180 DEG C, adds butanediol, sweet
Oil, maleic anhydride, ammonium dihydrogen phosphate, PLA and 2,6- three-level butyl -4- methylphenols, ultrasound 15min under the conditions of 90 DEG C, are obtained
To compound；
（2）To step（1）Send into double screw extruder and granulate in gained compound, cool down, dry, mother is obtained after cutting
Grain, wherein double screw extruder temperature are 230 DEG C, and screw speed is 900r/min；
（3）By step（2）Gained master batch is heated to 130 DEG C, by spinneret formation primary filament, then in 70 DEG C of water-bath
Middle carry out succeeding stretch, is produced described suitable for intracutaneous suture.
Comparative example 2
Difference with embodiment 5 is to be not added with 2,6- three-level butyl -4- methylphenols.
It is a kind of to be applied to intracutaneous suture, it is made up of each component of following mass parts：53 parts of polypropylene, butanediol 26
Part, 14 parts of glycerine, 12 parts of maleic anhydride, 7 parts of ammonium dihydrogen phosphate, 19 parts of PLA, 6 parts of PGA.
Preparation method：
（1）By above-mentioned mass parts, polypropylene is placed in reactor, is melted under the conditions of 180 DEG C, adds butanediol, sweet
Oil, maleic anhydride, ammonium dihydrogen phosphate, PLA and PGA, ultrasound 15min under the conditions of 90 DEG C, obtain compound；
（2）To step（1）Send into double screw extruder and granulate in gained compound, cool down, dry, mother is obtained after cutting
Grain, wherein double screw extruder temperature are 230 DEG C, and screw speed is 900r/min；
（3）By step（2）Gained master batch is heated to 130 DEG C, by spinneret formation primary filament, then in 70 DEG C of water-bath
Middle carry out succeeding stretch, is produced described suitable for intracutaneous suture.
Performance test：
Clinical test is carried out using embodiment 1-5 suture, sample is 100 people, is divided into 5 groups, every group of 10 male 10 female,
Do not occur side effect.
Suture the performance test results made from embodiment 1-5 and comparative example 1-2 are as shown in the table：
| Tensile strength（kg/cm） | Elongation（%） | Frictional force（cN） | |
| Embodiment 1 | 1.68 | 28.5 | 7.32 |
| Embodiment 2 | 1.72 | 29.1 | 7.27 |
| Embodiment 3 | 1.69 | 29.6 | 7.03 |
| Embodiment 4 | 1.77 | 30.9 | 6.89 |
| Embodiment 5 | 1.83 | 31.7 | 6.56 |
| Comparative example 1 | 1.03 | 22.8 | 10.32 |
| Comparative example 2 | 1.28 | 19.6 | 12.74 |
As can be seen from the above table：Suture tensile strength made from embodiment 1-5 between 1.68-1.83 kg/cm,
Elongation is between 28.5-31.7%, and frictional force is 6.56-7.32 cN, and is not added with PGA in comparative example 1, obtained
Suture tensile strength is 1.03kg/cm, and elongation is 22.8%, and frictional force is 10.32cN；2,6- are not added with comparative example 2
Three-level butyl -4- methylphenols, obtained suture tensile strength is 1.28kg/cm, and elongation is 19.6%, frictional force is
12.74cN.It follows that suture produced by the present invention is by the synergy between component, can improve tensile strength and
Elongation, reduces frictional force, it is adaptable to intradermal suture, can be widely used for clinical treatment.
Claims (4)
1. a kind of be applied to intracutaneous suture, it is characterised in that is made up of the component of following mass parts：45-63 parts of polypropylene,
17-29 parts of butanediol, 9-18 parts of glycerine, 5-21 parts of maleic anhydride, 2-11 parts of ammonium dihydrogen phosphate, 13-27 parts of PLA, poly- second are handed over
2-10 parts of ester, 4-18 parts of 2,6- three-level butyl -4- methylphenols；Preparation method：(1) above-mentioned mass parts are pressed, polypropylene is placed in
In reactor, melted under the conditions of 160-210 DEG C, add butanediol, glycerine, maleic anhydride, ammonium dihydrogen phosphate, PLA, poly-
Glycolide and 2,6- three-level butyl -4- methylphenols, ultrasound 10-20min under the conditions of 80-100 DEG C, obtain compound；(2) to step
Suddenly granulate, cool down in feeding double screw extruder in compound obtained by (1), dry, master batch is obtained after cutting；(3) by step (2)
Gained master batch is heated to 120-150 DEG C, by spinneret formation primary filament, then carries out in 50-80 DEG C of water-bath secondary drawing
Stretch, produce described suitable for intracutaneous suture.
2. it is according to claim 1 a kind of suitable for intracutaneous suture, it is characterised in that by the component of following mass parts
Composition：48-59 parts of polypropylene, 21-27 parts of butanediol, 11-16 parts of glycerine, 7-15 parts of maleic anhydride, 4-9 parts of ammonium dihydrogen phosphate,
15-23 parts of PLA, 4-8 parts of PGA, 5-12 parts of 2,6- three-level butyl -4- methylphenols.
3. it is according to claim 1 a kind of suitable for intracutaneous suture, it is characterised in that by the component of following mass parts
Composition：It is 53 parts of polypropylene, 26 parts of butanediol, 14 parts of glycerine, 12 parts of maleic anhydride, 7 parts of ammonium dihydrogen phosphate, 19 parts of PLA, poly-
6 parts of glycolide, 9 parts of 2,6- three-level butyl -4- methylphenols.
4. it is according to claim 1 a kind of suitable for intracutaneous suture, it is characterised in that double spiral shells in the step (2)
Bar extruder temperature is 210-260 DEG C, and screw speed is 700-1000r/min.
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| CN201510308466.2A CN104940986B (en) | 2015-06-08 | 2015-06-08 | It is a kind of to be applied to intracutaneous suture and preparation method thereof |
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| CN104940986B true CN104940986B (en) | 2017-08-25 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| GB0202233D0 (en) * | 2002-01-31 | 2002-03-20 | Smith & Nephew | Bioresorbable polymers |
| GB0317192D0 (en) * | 2003-07-19 | 2003-08-27 | Smith & Nephew | High strength bioresorbable co-polymers |
| CN101265609B (en) * | 2008-04-28 | 2011-12-28 | 上海聚睿生物材料有限公司 | Medical fiber preparation method and uses thereof |
| CN101380484A (en) * | 2008-06-30 | 2009-03-11 | 李捷 | Medical operation suture thread |
| CN101721739B (en) * | 2008-10-10 | 2013-02-13 | 陈东 | Polymer composite fiber surgical suture line capable of sustaining and controlling release of therapeutic medicaments and preparation method thereof |
| CN101962470B (en) * | 2009-07-22 | 2012-12-26 | 中国海洋石油总公司 | Biodegradable polypropylene carbonate composite material and preparation method thereof |
| CN102115558B (en) * | 2010-12-29 | 2013-01-23 | 四川大学 | High-conductivity polymer carbon nanotube composite material and micro-processing method thereof |
| CN104069540A (en) * | 2013-03-27 | 2014-10-01 | 朱华 | Medical macromolecule biologic suture line |
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