CN104940707A - Medicine for treating infant rachitis - Google Patents
Medicine for treating infant rachitis Download PDFInfo
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- CN104940707A CN104940707A CN201510425075.9A CN201510425075A CN104940707A CN 104940707 A CN104940707 A CN 104940707A CN 201510425075 A CN201510425075 A CN 201510425075A CN 104940707 A CN104940707 A CN 104940707A
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Abstract
The invention relates to a medicine for treating the infant rachitis. The medicine comprises, by weight, 1-10 parts of huaning vines, 1-10 parts of mentha spicata, 20-30 parts of oysters, 10-20 parts of tortoise shells, 1-10 parts of flowers of franchet peashrub, 10-20 parts of foxtail millet seeds, 1-10 parts of rhizoma atractylodis, 10-20 parts of boxleaf syzygium roots, 1-10 parts of clove fruits, 5-15 parts of uncaria, 10-20 parts of love-lies-bleeding roots, 1-10 parts of common hawksbeard, 10-20 parts of Chinese yams, 5-15 parts of orchis, 10-20 parts of thinleaf milkwort root-bark, 5-15 parts of frictus tsaoko, 10-20 parts of castanea seguinii node leaves and 1-10 parts of liquoric roots. The medicine achieves a synergistic effect, is complementary, achieves the functions of monarch, minister, assistant and guide, has the effects of strengthening the spleen, reinforcing the kidneys, tonifying qi, calming the liver and strengthening tendons and bones, has a definite treatment effect on infant rachitis, and is safe, free of toxic and side effects and worthy of clinical popularization.
Description
The divisional application of the patent of " a kind of medicament for the treatment of Rickets In Infants And Children " that the present invention is application number is 201510083139.1, the applying date, to be February 15, denomination of invention in 2015 be.
Technical field
The present invention relates to field of medicaments, relate in particular to a kind of medicament for the treatment of Rickets In Infants And Children.
Background technology
Vitamin D deficiency, also known as osteomalacia, is the chronic deficiency disease of one because the Ca,P metabolism in infants caused by vitamin d insufficiency is not normal, clinically with skeleton calcification obstacle for principal character, be more common in the infant of less than 2 years old.Its mainly with vitamin D Deficiency of Intake, to lack the factors such as sunshine, perinatal stage vitamin D under-reserve, infant fast growth relevant.Vitamin D deficiency causes intestinal absorption calcium, phosphorus to reduce and hypocalcemia, so that parathyroid hormone (PTH) secretion increases to mobilize bone calcium to disengage, and maintains serum calcium cancentration normally or close to normal level.When in children's's body during vitamin D deficiency, bone calcification is not enough.It is the infringement maintaining calcium level and cause skeleton that vitamin D deficiency can regard body as.As treated not in time, the growth promoter of child's multisystem can be affected.
Chinese medicine thinks Rickets In Infants And Children mainly because spleen kidney deficiency to cause the trouble that restriction or checking relation in five elements makes mutually, the card of clinical common fright at night, agitation, hyperhidrosis with depression of liver-QI.The kidney being the origin of congenital constitution, and spleen is the source of vital function day after tomorrow, kidney governing bones marrow, spleen governing muscles, when congenital void is lost, the day after tomorrow feeds inappropriate, with breast feeding, can not add that sunshine not enough, all can cause deficient qi and blood, affect spleen renal function, so that bone marrow does not fill, osteoporosis, skeletonization is slow, even skeleton deformity.
Summary of the invention
The object of this invention is to provide a kind of medicament for the treatment of Rickets In Infants And Children.
In order to realize object of the present invention, the invention provides a kind of medicament for the treatment of Rickets In Infants And Children, it is made up of the material of following weight portion: Gymnema yunnanense Tsiang 1-10 part, Herba Menthae Rotundifoliae 1-10 part, Concha Ostreae 20-30 part, Carapax Et Plastrum Testudinis 10-20 part, Flos Caraganae Franchetianae 1-10 part, Semen Setariae italicae 10-20 part, Rhizoma Atractylodis Macrocephalae 1-10 part, Radix Syzygii Buxifolii root 10-20 part, Fructus Caryophylli 1-10 part, Ramulus Uncariae Cum Uncis 5-15 part, Radix Amaranthi Caudati 10-20 part, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 1-10 part, Rhizoma Dioscoreae 10-20 part, Herba Orchidis Latifoliae 5-15 part, Radix Polygalae 10-20 part, cannon Fructus Tsaoko 5-15 part, Castanea seguinii Dode (Involucrum Castaneae Seguinii) leaf 10-20 part and Radix Glycyrrhizae 1-10 part.
Preferably, the medicament for the treatment of Rickets In Infants And Children of the present invention is made up of the material of following weight portion: Gymnema yunnanense Tsiang 8 parts, Herba Menthae Rotundifoliae 10 parts, Concha Ostreae 30 parts, Carapax Et Plastrum Testudinis 15 parts, Flos Caraganae Franchetianae 8 parts, Semen Setariae italicae 15 parts, the Rhizoma Atractylodis Macrocephalae 5 parts, Radix Syzygii Buxifolii root 12 parts, Fructus Caryophylli 8 parts, Ramulus Uncariae Cum Uncis 10 parts, Radix Amaranthi Caudati 15 parts, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 5 parts, Rhizoma Dioscoreae 15 parts, Herba Orchidis Latifoliae 12 parts, Radix Polygalae 15 parts, cannon Fructus Tsaoko 10 parts, 12 parts, Castanea seguinii Dode (Involucrum Castaneae Seguinii) leaf and 9 parts, Radix Glycyrrhizae.
More preferably, described medicament can be tablet, dispersible tablet, capsule, soft capsule, powder or pill.
The present invention also provides the purposes of compositions in the medicine of preparation treatment Rickets In Infants And Children, and described compositions is made up of the material of following weight portion: Gymnema yunnanense Tsiang 1-10 part, Herba Menthae Rotundifoliae 1-10 part, Concha Ostreae 20-30 part, Carapax Et Plastrum Testudinis 10-20 part, Flos Caraganae Franchetianae 1-10 part, Semen Setariae italicae 10-20 part, Rhizoma Atractylodis Macrocephalae 1-10 part, Radix Syzygii Buxifolii root 10-20 part, Fructus Caryophylli 1-10 part, Ramulus Uncariae Cum Uncis 5-15 part, Radix Amaranthi Caudati 10-20 part, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 1-10 part, Rhizoma Dioscoreae 10-20 part, Herba Orchidis Latifoliae 5-15 part, Radix Polygalae 10-20 part, cannon Fructus Tsaoko 5-15 part, Castanea seguinii Dode (Involucrum Castaneae Seguinii) leaf 10-20 part and Radix Glycyrrhizae 1-10 part.
Preferably, described compositions is made up of the material of following weight portion: Gymnema yunnanense Tsiang 8 parts, Herba Menthae Rotundifoliae 10 parts, Concha Ostreae 30 parts, Carapax Et Plastrum Testudinis 15 parts, Flos Caraganae Franchetianae 8 parts, Semen Setariae italicae 15 parts, the Rhizoma Atractylodis Macrocephalae 5 parts, Radix Syzygii Buxifolii root 12 parts, Fructus Caryophylli 8 parts, Ramulus Uncariae Cum Uncis 10 parts, Radix Amaranthi Caudati 15 parts, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 5 parts, Rhizoma Dioscoreae 15 parts, Herba Orchidis Latifoliae 12 parts, Radix Polygalae 15 parts, cannon Fructus Tsaoko 10 parts, 12 parts, Castanea seguinii Dode (Involucrum Castaneae Seguinii) leaf and 9 parts, Radix Glycyrrhizae.
More preferably, described medicine can be tablet, dispersible tablet, capsule, soft capsule, powder or pill.
In the present compositions, Gymnema yunnanense Tsiang, Radix Syzygii Buxifolii root, Carapax Et Plastrum Testudinis are monarch drug; Herba Menthae Rotundifoliae, cannon Fructus Tsaoko, Semen Setariae italicae, Crepis crocea Babc.(C.turczaninowii C.A.Mey.), Concha Ostreae are ministerial drug; Flos Caraganae Franchetianae, the Rhizoma Atractylodis Macrocephalae, Fructus Caryophylli, Ramulus Uncariae Cum Uncis, Radix Amaranthi Caudati, Rhizoma Dioscoreae, Herba Orchidis Latifoliae, Radix Polygalae, Castanea seguinii Dode (Involucrum Castaneae Seguinii) leaf are adjuvant drug; Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription, for making medicine.
Medicament synergism of the present invention, to complement each other, play the merit of monarch altogether, have effect of strengthening spleen, tonifying kidney, QI invigorating suppressing the hyperactive liver, bone and muscle strengthening, treatment Rickets In Infants And Children determined curative effect and safe without toxic side effect, clinic is promoted.
Detailed description of the invention
The present invention is further illustrated below by embodiment.It should be understood that embodiments of the invention are for illustration of the present invention instead of limitation of the present invention.Essence according to the present invention all belongs to the scope of protection of present invention to the simple modifications that the present invention carries out.Unless otherwise stated, the percent in the present invention is percetage by weight.
The preparation of embodiment medicament of the present invention
For powder, the preparation technology of medicament of the present invention is as follows:
(1) Gymnema yunnanense Tsiang 80 grams, cannon Fructus Tsaoko 100 grams, Semen Setariae italicae 150 grams, Radix Polygalae 150 grams, Ramulus Uncariae Cum Uncis 100 grams is taken, add 75 volume % ethanol water 5000 milliliters, heating 2 hours under the condition of backflow, be cooled to room temperature, filter, ethanol in reclaim under reduced pressure filtrate, is then dried to constant weight, obtains powder 1;
(2) Herba Menthae Rotundifoliae 100 grams, Concha Ostreae 300 grams, Carapax Et Plastrum Testudinis 150 grams, Flos Caraganae Franchetianae 80 grams, the Rhizoma Atractylodis Macrocephalae 50 grams, Radix Syzygii Buxifolii root 120 grams, Fructus Caryophylli 80 grams, Radix Amaranthi Caudati 150 grams, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 50 grams, Rhizoma Dioscoreae 150 grams, Herba Orchidis Latifoliae 120 grams, 120 grams, Castanea seguinii Dode (Involucrum Castaneae Seguinii) leaf and 90 grams, Radix Glycyrrhizae is taken, add 6000 ml waters, reflux 3 hours in the flask that condensing tube is housed, be cooled to room temperature, filter, make filtrate evaporate to dryness to constant weight, obtain powder 2;
(3) merge powder 1 and powder 2, mix homogeneously, is dispensed in 1000 bags, obtains powder of the present invention.
The curative effect of experimental example medicament of the present invention
1 data and method
1.1 physical data
This group child suffering from rickets is totally 60 examples, all meets the diagnostic criteria in 1986 " national prevention of rickets scheme and diagnostic criteria ", gets rid of liver, kidney, endocrine metabolism and other congenital diseases through comprehensive health check-up.60 routine infants are divided into treatment group 30 example and matched group 30 example.Wherein treatment group man 16 example, female 14 example; Children age between the 6-14 monthly age, 10.8 months mean aves; Pure breast feeding 19 example, breast milk laboratory milk mixed feeding 11 example.Matched group man 17 example, female 13 example; Children age between the 8-15 monthly age, 11.2 months mean aves; Pure breast feeding 18 example, breast milk laboratory milk mixed feeding 12 example.Two groups of infants, at the equal not statistically significant of the difference of above-mentioned each side (p > 0.05), have comparability.
1.2 observation index
1.2.1 clinical symptoms and sign
Before treatment and after treatment, observe the improvement situation of rickets clinical symptoms and sign, comprising: fright at night, hyperhidrosis, hair be rare, it is bald to rest the head on, costal margin turns up.
1.2.2 bone density
Israel Sunlight company Omnisense7000 type quantitative ultrasound bone strength instrument is utilized to measure the tibial bone density before and after two groups of infant treatments by standard operating instructions.The asian children data base provided by Sunlight company is reference standard calculating, automatically drawing bone density standard deviation Z value, is bone density wretched insufficiency below-2, is that bone density moderate is not enough below-1, less than 0 is that bone density is slightly not enough, and more than 0 or 0 is that bone density is normal.
1.3 Therapeutic Method
Treatment group takes the powder of the present invention prepared in embodiment, 1 bag/day, and twice sub-service sooner or later, taking continuously 30 days is a course for the treatment of, treats 2 courses for the treatment of.Matched group takes compound recipe Calcium Gluconate Oral Solution (the accurate word H10980268 of traditional Chinese medicines, Nanjing Te Feng Pharmaceutical limited company produces), and 1 (10 milliliters)/time, 3 times/day, taking continuously 30 days is a course for the treatment of, treats 2 courses for the treatment of.
1.4 criterion of therapeutical effect
Clinical efficacy evaluation criteria is as follows:
Effective: clinical symptoms, sign disappear; Bone density is obviously improved
Effective: clinical symptoms, sign are obviously alleviated; Bone density makes moderate progress
Invalid: clinical symptoms, sign are without alleviation; Bone density is without improvement
Effective percentage=(effective+effectively) number of cases/total number of cases × 100%
1.5 statistical method
SPSS15.0 statistical software is adopted to carry out data analysis.Measurement data with
represent, adopt t inspection; Enumeration data adopts x
2inspection.Be that difference has statistical significance with p<0.05.
2 results
2.1 clinical symptoms, sign
Before and after the treatment of two groups of infants clinical symptoms, sign improve relatively in table 1.
The comparison that table 1 liang group infant clinical symptoms, sign are improved
As can be seen from Table 1, two groups of infants symptom, sign situation contrast difference not statistically significant (p > 0.05) before the treatment, and after treating 2 courses for the treatment of, clinical symptoms, the sign for the treatment of group and matched group are alleviated all to some extent, and the group difference for the treatment of group and matched group has statistical significance (p<0.05).
2.2 bone density
Bone mineral density results relatively in table 2 before and after the treatment of two groups of infants.
The comparison of table 2 liang group infant bone density change
Note: compare with before treatment, * p<0.05; Compare with matched group, * * p<0.05
As can be seen from Table 2, treating front two groups of infant Bone mineral density results is all wretched insufficiency (Z value <-2), and no significant difference (p > 0.05), and after treating 2 courses for the treatment of, the bone density of two groups all makes moderate progress, difference has statistical significance (p<0.05), group difference also has statistical significance (p<0.05), shows that the recovery situation for the treatment of group bone density is better than matched group infant.
2.3 effective percentage
Clinical efficacy after two groups of infant treatments is in table 3.
Table 3 Clinical efficacy comparison
Note: compare with matched group, * p<0.05
Table 3 shows, and the difference of two groups of infant clinical efficacies has statistical significance (p<0.05), shows that the clinical efficacy of medicament of the present invention is better than compound recipe Calcium Gluconate Oral Solution.
Claims (3)
1. the purposes of compositions in the medicine of preparation treatment Rickets In Infants And Children, is characterized in that described compositions is made up of the material of following weight portion: Gymnema yunnanense Tsiang 1-10 part, Herba Menthae Rotundifoliae 1-10 part, Concha Ostreae 20-30 part, Carapax Et Plastrum Testudinis 10-20 part, Flos Caraganae Franchetianae 1-10 part, Semen Setariae italicae 10-20 part, Rhizoma Atractylodis Macrocephalae 1-10 part, Radix Syzygii Buxifolii root 10-20 part, Fructus Caryophylli 1-10 part, Ramulus Uncariae Cum Uncis 5-15 part, Radix Amaranthi Caudati 10-20 part, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 1-10 part, Rhizoma Dioscoreae 10-20 part, Herba Orchidis Latifoliae 5-15 part, Radix Polygalae 10-20 part, cannon Fructus Tsaoko 5-15 part, Castanea seguinii Dode (Involucrum Castaneae Seguinii) leaf 10-20 part and Radix Glycyrrhizae 1-10 part.
2. purposes according to claim 1, wherein said compositions is made up of the material of following weight portion: Gymnema yunnanense Tsiang 8 parts, Herba Menthae Rotundifoliae 10 parts, Concha Ostreae 30 parts, Carapax Et Plastrum Testudinis 15 parts, Flos Caraganae Franchetianae 8 parts, Semen Setariae italicae 15 parts, the Rhizoma Atractylodis Macrocephalae 5 parts, Radix Syzygii Buxifolii root 12 parts, Fructus Caryophylli 8 parts, Ramulus Uncariae Cum Uncis 10 parts, Radix Amaranthi Caudati 15 parts, Crepis crocea Babc.(C.turczaninowii C.A.Mey.) 5 parts, Rhizoma Dioscoreae 15 parts, Herba Orchidis Latifoliae 12 parts, Radix Polygalae 15 parts, cannon Fructus Tsaoko 10 parts, 12 parts, Castanea seguinii Dode (Involucrum Castaneae Seguinii) leaf and 9 parts, Radix Glycyrrhizae.
3. purposes according to claim 1 and 2, wherein said medicine can be tablet, dispersible tablet, capsule, soft capsule, powder or pill.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510083139.1A CN104587280B (en) | 2015-02-15 | 2015-02-15 | A kind of medicament for the treatment of Rickets In Infants And Children |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN201510083139.1A Division CN104587280B (en) | 2015-02-15 | 2015-02-15 | A kind of medicament for the treatment of Rickets In Infants And Children |
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| CN104940707A true CN104940707A (en) | 2015-09-30 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510425075.9A Pending CN104940707A (en) | 2015-02-15 | 2015-02-15 | Medicine for treating infant rachitis |
| CN201510083139.1A Expired - Fee Related CN104587280B (en) | 2015-02-15 | 2015-02-15 | A kind of medicament for the treatment of Rickets In Infants And Children |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201510083139.1A Expired - Fee Related CN104587280B (en) | 2015-02-15 | 2015-02-15 | A kind of medicament for the treatment of Rickets In Infants And Children |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1958050A (en) * | 2005-10-08 | 2007-05-09 | 刘国飞 | Composition of Chinese traditional medicine for treating wean rickets, and preparation method |
| CN101164597A (en) * | 2007-09-29 | 2008-04-23 | 王龙宝 | Traditional Chinese medicine for treating infantile rickets |
| CN104147344A (en) * | 2014-07-23 | 2014-11-19 | 武汉健民药业集团股份有限公司 | Preparation method of Longmu Zhuanggu granule |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070292493A1 (en) * | 2006-06-15 | 2007-12-20 | Brierre Barbara T | Pharmaceutical composition and method for the transdermal delivery of calcium |
| CN101129956B (en) * | 2007-08-25 | 2010-06-02 | 刘衍 | Traditional Chinese medicine for treating rickets |
-
2015
- 2015-02-15 CN CN201510425075.9A patent/CN104940707A/en active Pending
- 2015-02-15 CN CN201510083139.1A patent/CN104587280B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1958050A (en) * | 2005-10-08 | 2007-05-09 | 刘国飞 | Composition of Chinese traditional medicine for treating wean rickets, and preparation method |
| CN101164597A (en) * | 2007-09-29 | 2008-04-23 | 王龙宝 | Traditional Chinese medicine for treating infantile rickets |
| CN104147344A (en) * | 2014-07-23 | 2014-11-19 | 武汉健民药业集团股份有限公司 | Preparation method of Longmu Zhuanggu granule |
Non-Patent Citations (1)
| Title |
|---|
| 李凤萍: "麦儿片治疗疳证临床观察", 《现代中医药》 * |
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| Publication number | Publication date |
|---|---|
| CN104587280B (en) | 2015-09-16 |
| CN104587280A (en) | 2015-05-06 |
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