CN100388942C - Leukemia treating Chinese medicine composition and its prepn - Google Patents
Leukemia treating Chinese medicine composition and its prepn Download PDFInfo
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- CN100388942C CN100388942C CNB2005101032636A CN200510103263A CN100388942C CN 100388942 C CN100388942 C CN 100388942C CN B2005101032636 A CNB2005101032636 A CN B2005101032636A CN 200510103263 A CN200510103263 A CN 200510103263A CN 100388942 C CN100388942 C CN 100388942C
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Abstract
The present invention discloses a Chinese medicinal composition for treating leukemia, and a preparation method thereof. The preparation of the Chinese medicinal composition is prepared from the following components as raw materials: 3 to 10 of ginseng, 5 to 15 of radix codonopsitis, 5 to 15 of solomonseal rhizome, 5 to 15 of largehead atractylodes rhizome, 5 to 15 of milkvetch root, 10 to 20 of human placenta, 10 to 20 of angelica, 3 to 10 of hemlock parsley, 10 to 20 of white peony alba, 10 to 20 of prepared rhizome of rehmannia, 10 to 16 of donkey-hide gelatin, 8 to 16 of fleece-flower root, 10 to 20 of mulberry fruit, 10 to 20 of dried longan pulp, 10 to 20 of cypress nucleus, 10 to 20 of cooked jujube seed, 10 to 20 of flos albiziae, 10 to 20 of dodder seed, 10 to 20 of barbary wolfberry fruit, 10 to 20 of raspberry, 8 to 16 of glue of tortoise plastron, 10 to 20 of eucommia bark, 10 to 20 of twotooth achyranthes root, 10 to 20 of charred triplet, 8 to 18 of villous amomum fruit, 6 to 18 of lotus seed, 3 to 8 of ophiopogon root, 10 to 20 of cornus and 10 to 20 of carbonized human hair. The present invention is a pure Chinese medicineal preparation having the advantages of conspicuous curative effect and no toxic or side effect.
Description
Technical field
The present invention relates to the leukemic medicine of a kind of treatment, relate in particular to leukemic Chinese medicine pharmaceutical composition of a kind of treatment and preparation method thereof.
Background technology
Leukemia is a kind of malignant tumor, claim leukemia, be the depletion of hemopoietic system hemopoietic tissue hemopoietic function, causing erythrocyte and platelet to generate reduces, granulocytopenia or increase, cause the uncontrolled neoplasm of certain a series of hemocyte and soak into each tissue of body, cause the enlargement of anemia, heating, hemorrhage, liver spleen and the different Cheng Du of lymph node.This diease occurrence stubbornness, complicated classification, the teenager below 35 years old in serious threat, this disease of world medicine bound pair is attached great importance to, because etiology unknown, the reliable way for the treatment of this disease is treated this at present and sickly mainly by ways such as blood transfusion, change-blood, chemotherapy, bone marrow transplantations life is postponed separating keeping still in discussion, in case occur hyperpyrexia, hemorrhage, be exactly that life is critical.The leukemic method of present treatment has multiple, but has weak curative effect, the side effect important disadvantages.The inventor removes heresy according to above comprehensive therapeutic plan to set upright, and cultivates the means of hemopoietic function, effects a radical cure this disease, selects medicine of the present invention.
Summary of the invention
The purpose of this invention is to provide leukemic Chinese medicine pharmaceutical composition of a kind of treatment and preparation method thereof, overcome the shortcoming of said medicine.
The objective of the invention is to be achieved through the following technical solutions:
The leukemic Chinese medicine pharmaceutical composition of a kind of treatment provided by the invention is by the preparation that comprises that following raw material components is made: Radix Ginseng 3-10, Radix Codonopsis 5-15, Rhizoma Polygonati 5-15, Rhizoma Atractylodis Macrocephalae 5-15, Radix Astragali 5-15, Placenta Hominis 10-20, Radix Angelicae Sinensis 10-20, Rhizoma Chuanxiong 3-10, Radix Paeoniae Alba 10-20, Radix Rehmanniae Preparata 10-20, Colla Corii Asini 10-16, He Daowu 8-16, Mulberry is born 10-20, Arillus Longan 10-20, Semen Platycladi 10-20, ripe Semen Ziziphi Spinosae 10-20, Flos Albiziae 10-20 Semen Cuscutae 10-20, Fructus Lycii 10-20, Fructus Rubi 10-20, Colla Plastri Testudinis 8-16, Cortex Eucommiae 10-20, river cattle sunset 10-20, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 10-20, Fructus Amomi 8-18, Semen Nelumbinis 6-18, Radix Ophiopogonis 3-8, Fructus Corni 10-20, Crinis Carbonisatus 10-20;
Described raw material components is preferably following parts by weight of component: Radix Ginseng 6, Radix Codonopsis 10, Rhizoma Polygonati 10, the Rhizoma Atractylodis Macrocephalae 10, the Radix Astragali 10, Placenta Hominis 15, Radix Angelicae Sinensis 15, Rhizoma Chuanxiong 6, the Radix Paeoniae Alba 15, Radix Rehmanniae Preparata 15, Colla Corii Asini 13, what road crow 12, Mulberry bear 15, Arillus Longan 15, Semen Platycladi 15, ripe Semen Ziziphi Spinosae 15, Flos Albiziae 15, Semen Cuscutae 15, Fructus Lycii 15, Fructus Rubi 15, Colla Plastri Testudinis 12, the Cortex Eucommiae 15, river cattle sunset 15, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 15, Fructus Amomi 13, Semen Nelumbinis 12, Radix Ophiopogonis 5, Fructus Corni 15, Crinis Carbonisatus 15.
Described preparation can be any pharmaceutical preparation commonly used, especially is pill, powder, capsule, tablet, oral liquid.
The present invention also provides the leukemic Chinese medicine preparation of drug combination of a kind of treatment method, and may further comprise the steps: the weighting profit requires the raw material components of one of 1-2, pulverize separately, mixing, make medicament according to a conventional method, as pill, powder, capsule, tablet, oral liquid.
Described preparation method step can also be: get the above-mentioned raw materials component, pulverize separately, mixing are made standby loosing; Add in right amount by standby diffusing quantity in addition, go into pot as 90% Mel and be fried boiling, take out and filter, reenter pot and be fried boiling, adding is an amount of again, puts in the Mel pot that is fried boiling as 10% pure water to be fried boiling 1-3 minute, best 2 minutes, more standby loose slowly gone into pot and stirred evenly, take out pill.Ball heavily can be 9 grams.
The present invention can be made into multiple dosage form, as, system powder: the gram quantity by the every flavor medicine of 30 flavor medicines goes out medicated powder, is mixed evenly, and powder then becomes.
As, glue capsule: during powder incapsulated, then become capsule.
As, above-mentioned pill agent method: the standby diffusing honey that adds is gone into a pot taking-up pill.
As, system oral liquid: by the quantity of flavour of a drug separately, add water, put in the pot and be fried boiling, take out and filter bottling, oral liquid then becomes.Can be poured on medicinal liquid in the bowl when taking medicine, take after mixing it with water with boiled water, get final product with the brown sugar amount is suitable with brown sugar.
The present invention is that the inventor is on the basis of motherland's theory of medicine, the leukemic disease symptom and the state of an illness are shown, further use the means of anatomical, segmentation understanding and analysis are in conjunction with hoping, hear, ask, cut the four diagnostic methods, debate the eight guiding principles for diagnosis situation of other internal organs in detail, distinguish negative and positive, the exterior and the interior, deficiency and excess, cold and heat, caught this sick pathogenesis theme, tell six ones return through, from treatment, given play to three kinds of characteristics of medicine, the means that leukemia resists have been treated.
Chinese medicine of the present invention is returned through treatment leukemic: the medicine of 1, cultivating healthy energy: Radix Ginseng, Radix Codonopsis, the Radix Astragali, Placenta Hominis, Rhizoma Polygonati; 2, the medicine of nutrition blood: Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Radix Polygoni Multiflori, Colla Corii Asini, Arillus Longan, Crinis Carbonisatus; 3, add the smart medicine of mending marrow: Fructus Corni, Semen Cuscutae, Fructus Rubi, Fructus Lycii, the Cortex Eucommiae, river Niu Xi, Colla Plastri Testudinis, Fructus Amomi; 4, pacify the medicine of heart: ripe Semen Ziziphi Spinosae, Semen Platycladi, Herba Albiziae; 5, the medicine of clear and rich lungs: Radix Ophiopogonis, Semen Nelumbinis; 6, the medicine of spleen invigorating stomach strengthening: the Rhizoma Atractylodis Macrocephalae, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata), Mulberry are born.Above medicine, divide six ones return through.Return through therapeutic process in, medicine is restrained mutually, supports mutually again, plays therapeutical effect.
Chinese medicine of the present invention, it is three hours that the patient takes medicine in the capable medicine of the intestines and stomach time, in this capable medicine process of three hours, medicine six ones return through the treatment task finish, full three hours, the efficacy of a drug consumes 50%, and at this time, the efficacy of a drug enters blood, circulate with blood, in cyclic process, the efficacy of a drug is returned six ones through becoming four combinations greatly, and four in the treatment blood is tissue (granulocyte greatly, erythrocyte, lymphocyte, mononuclear cell), this support that increases increases, this minimizing kill minimizing, outgrowth nucleated cell is dissolved, recover due quantity, promote to recover hemopoietic function, progressively reversing the anemia phenomenon, because the life of blood cell is terminable, is to update progressively to produce progressively to disappear.Impel down in the efficacy of a drug, no matter blood or cell, a generation generation is reversed the situation of anemia.
Chinese medicine composition function of the present invention cures mainly: help that gas is supported, the liver and the kidney tonifying, add smart marrow, reinforcing the heart lung heat clearing, the spleen invigorating stomach strengthening mended.
The present invention has the following advantages:
1, pure Chinese medicinal preparation of the present invention, have evident in efficacy, treating both the principal and secondary aspects of a disease, the advantage that has no side effect.
2, from cloudy, from sun internal organs, the blood of body are treated respectively.
3, Chinese medicine of the present invention is by sterilization, can make ball, looses, capsule, the multiple dosage form of oral liquid, and checker is taken, and allows the patient adhere to taking medicine in the very long course of treatment.
Be the advantage of proof said medicine of the present invention, the present invention has carried out embodiment 1 pill clinical trial:
One, case is selected: wide, narrow according to high and low, wide, general situation of leukemic sickness rate and leukemia kind involvement aspect, select 200 representational cases, and cover and draw together vast leukaemic.
Two, case is as follows:
1, anxious grain is 60: anxious grain is the abbreviation of acute myeloblastic leukemia, is human popular leukemia the most widely, and the harm target is young and middle-aged.
2, anxious pouring is 60, and anxious the pouring is the abbreviation of acute lymphoblastic leukemia, is the more pandemic leukemia of the mankind, and the harm target is the child below 13 years old.
3, anxious single 40: anxious singly is the abbreviation of acute monocytic leukemia, is rare leukemia, harm target adult.
4, drench 40 slowly: drenching slowly is the abbreviation of chronic lymphocytic leukemia, is rare leukemia, and the harm target is the above old man of threescore.
More than four kinds of cases represent four kinds of different leukemia, to anxious pouring, to drenching slowly, to relatively extensively, see that from anxious grain from child to the young and the middle aged, from the young and the middle aged until old year, these four kinds of cases are representational thus from seldom seeing light from extensively from monokaryon.
Three, efficacy assessment standard
This medicine treatment leukemia, its effective evaluation, according to the blood test data before the patient treatment, data are looked in the blood examination of expiring three courses of treatment with treatment, Shanghai Science Press publishes with nineteen eighty-three, assert institution of higher learning's teaching material of Ministry of Public Health approval through the Chinese Academy of Sciences, and the clinical solution of doctor trained in Western medicine internal medicine publication checks that normal value is the blood data standard, compare, the blood data after three courses of treatment reaches standard for curing.
Below be the blood tissues normalized form:
Erythrocyte: male 4-5 * 10
12/ L (400-550 ten thousand/mm
3)
Woman 3.5-5.0 * 10
12/ L (350-500 ten thousand/mm
3)
Get middle number man 5 for convenience of calculation is called for short male 4-5.5 woman 3.5-5, woman 4 is for curing radix.
Hemoglobin: male 120-160g/L (12-16g/b1)
Woman 110-150g/L (11-15g/b1)
For convenience of calculation is called for short male 12-16g, women 11-15g goes up number man 14 woman 13 for curing radix in getting.
Leukocyte: the men and women is with using number 4.0-10.0 * 10
9/ L (4000-10000/mm
3) comprising 6 group numbers are stable with a slight decline the percentage ratio number arranged, as (1) neutrophilic granulocyte band form (2) neutrophilic granulocyte segmented form (3) eosinophilic granulocyte (4) basophil (5) lymphocyte (6) mononuclear cell, for just no longer classification of convenience of calculation, the general designation leukocyte, get mediant 7000 and be called for short 7, for curing radix.
Platelet men and women has two kinds of computing methods: (1) direct computing method 10,000-300,000/mm with using number
3(2) indirect calculation method 200,000-400,000, cut-off connects computing method and is advisable, and it is unified several 250,000 to get in one the number men and women, is called for short 25, is to cure radix.
These four groups of cells are the Main Ingredients and Appearance in the blood, and the other parts cell increases with the recovery of these four kinds of cells.
Instructions of taking: three months courses of treatment, oral powder, one time 9 gram, three times on the one.
Conclusion: effective percentage is 100%; Cure rate is 95%, produce effects 98%, invalid 0%.Take three months courses of treatment of this medicine, three courses of treatment, 95% patient can both rehabilitation.
The specific embodiment
Embodiment 1
The leukemic Chinese medicine pharmaceutical composition of a kind of treatment (powder)
Get following raw material components (kg): Radix Ginseng 6, Radix Codonopsis 10, Rhizoma Polygonati 10, the Rhizoma Atractylodis Macrocephalae 10, the Radix Astragali 10, Placenta Hominis 15, Radix Angelicae Sinensis 15, Rhizoma Chuanxiong 6, the Radix Paeoniae Alba 15, Radix Rehmanniae Preparata 15, Colla Corii Asini 13, what road crow 12, Mulberry bear 15, Arillus Longan 15, Semen Platycladi 15, ripe Semen Ziziphi Spinosae 15, Flos Albiziae 15, Semen Cuscutae 15, Fructus Lycii 15, Fructus Rubi 15, Colla Plastri Testudinis 12, the Cortex Eucommiae 15, river cattle sunset 15, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 15, Fructus Amomi 13, Semen Nelumbinis 12, Radix Ophiopogonis 5, Fructus Corni 15, Crinis Carbonisatus 15.
Preparation method: get the above-mentioned raw materials component, pulverize separately becomes 80 orders, and mixing is made standby loosing; In addition add 90% Mel by standby diffusing quantity and go into pot and be fried boiling, take out and filter, reenter pot and be fried boiling, add 10% pure water again and put in the Mel pot that is fried boiling and be fried boiling 2 minutes, more standby loosing slowly gone into pot and stirred evenly, take out pill, ball weighs 9 grams, pill.
Embodiment 2
The leukemic Chinese medicine pharmaceutical composition of a kind of treatment (powder)
Get following raw material components (kg): Radix Ginseng 3, Radix Codonopsis 5, Rhizoma Polygonati 5, the Rhizoma Atractylodis Macrocephalae 5, the Radix Astragali 5, Placenta Hominis 10, Radix Angelicae Sinensis 10, Rhizoma Chuanxiong 3, the Radix Paeoniae Alba 10, Radix Rehmanniae Preparata 10, Colla Corii Asini 10, what road crow 8, Mulberry bear 10, Arillus Longan 10, Semen Platycladi 10, ripe Semen Ziziphi Spinosae 10, Flos Albiziae 10, Semen Cuscutae 10, Fructus Lycii 10, Fructus Rubi 10, Colla Plastri Testudinis 8, the Cortex Eucommiae 10, river cattle sunset 10, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 10, Fructus Amomi 8, Semen Nelumbinis 6, Radix Ophiopogonis 3, Fructus Corni 10, Crinis Carbonisatus 10.
Preparation method: get the above-mentioned raw materials component, pulverize separately becomes 100 orders, and mixing is made powder, and package sterilization gets final product.
Embodiment 3
The leukemic Chinese medicine pharmaceutical composition of a kind of treatment (capsule or tablet)
Get following raw material components (kg): Radix Ginseng 10, Radix Codonopsis 15, Rhizoma Polygonati 15, the Rhizoma Atractylodis Macrocephalae 15, the Radix Astragali 15, Placenta Hominis 20, Radix Angelicae Sinensis 20, Rhizoma Chuanxiong 10, the Radix Paeoniae Alba 20, Radix Rehmanniae Preparata 20, Colla Corii Asini 16, what road crow 16, Mulberry bear 20, Arillus Longan 20, Semen Platycladi 20, ripe Semen Ziziphi Spinosae 20, Flos Albiziae 20, Semen Cuscutae 20, Fructus Lycii 20, Fructus Rubi 20, Colla Plastri Testudinis 16, the Cortex Eucommiae 20, river cattle sunset 20, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 20, Fructus Amomi 18, Semen Nelumbinis 18, Radix Ophiopogonis 8, Fructus Corni 20, Crinis Carbonisatus 20.
Preparation method: get the above-mentioned raw materials component, pulverize separately becomes 200 orders, and mixing is made powder, and encapsulated or tabletting gets final product.
Embodiment 4
The leukemic Chinese medicine pharmaceutical composition of a kind of treatment (oral liquid)
Get following raw material components (kg): Radix Ginseng 6, Radix Codonopsis 10, Rhizoma Polygonati 10, the Rhizoma Atractylodis Macrocephalae 10, the Radix Astragali 10, Placenta Hominis 15, Radix Angelicae Sinensis 15, Rhizoma Chuanxiong 6, the Radix Paeoniae Alba 15, Radix Rehmanniae Preparata 15, Colla Corii Asini 13, what road crow 12, Mulberry bear 15, Arillus Longan 15, Semen Platycladi 15, ripe Semen Ziziphi Spinosae 15, Flos Albiziae 15, Semen Cuscutae 15, Fructus Lycii 15, Fructus Rubi 15, Colla Plastri Testudinis 12, the Cortex Eucommiae 15, river cattle sunset 15, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 15, Fructus Amomi 13, Semen Nelumbinis 12, Radix Ophiopogonis 5, Fructus Corni 15, Crinis Carbonisatus 15.
Preparation method: get the above-mentioned raw materials component, pulverize separately becomes 80 orders, and mixing adds water, and putting into is fried boiling in the pot took out once more and to filter bottling in 2 minutes, oral liquid.When taking medicine medicinal liquid is poured in the bowl, takes after mixing it with water with boiled water with brown sugar, an amount of with brown sugar.
Claims (5)
1. treat leukemic Chinese medicine composition for one kind, it is the preparation of being made by following materials of weight proportions medicine: Radix Ginseng 3-10, Radix Codonopsis 5-15, Rhizoma Polygonati 5-15, Rhizoma Atractylodis Macrocephalae 5-15, Radix Astragali 5-15, Placenta Hominis 10-20, Radix Angelicae Sinensis 10-20, Rhizoma Chuanxiong 3-10, Radix Paeoniae Alba 10-20, Radix Rehmanniae Preparata 10-20, Colla Corii Asini 10-16, Radix Polygoni Multiflori 8-16, Fructus Mori 10-20, Arillus Longan 10-20, Semen Platycladi 10-20, ripe Semen Ziziphi Spinosae 10-20, Flos Albiziae 10-20, Semen Cuscutae 10-20, Fructus Lycii 10-20, Fructus Rubi 10-20, Colla Plastri Testudinis 8-16, Cortex Eucommiae 10-20, Radix Cyathulae 10-20, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 10-20, Fructus Amomi 8-18, Semen Nelumbinis 6-18, Radix Ophiopogonis 3-8, Fructus Corni 10-20, Crinis Carbonisatus 10-20.
2. according to the leukemic Chinese medicine composition of the treatment of claim 1, wherein the weight proportion of each crude drug is: Radix Ginseng 6, Radix Codonopsis 10, Rhizoma Polygonati 10, the Rhizoma Atractylodis Macrocephalae 10, the Radix Astragali 10, Placenta Hominis 15, Radix Angelicae Sinensis 15, Rhizoma Chuanxiong 6, the Radix Paeoniae Alba 15, Radix Rehmanniae Preparata 15, Colla Corii Asini 13, Radix Polygoni Multiflori 12, Fructus Mori 15, Arillus Longan 15, Semen Platycladi 15, ripe Semen Ziziphi Spinosae 15, Flos Albiziae 15, Semen Cuscutae 15, Fructus Lycii 15, Fructus Rubi 15, Colla Plastri Testudinis 12, the Cortex Eucommiae 15, Radix Cyathulae 15, JIAOSANXIAN (Fructus Crataegi, Fructus Hordei Germinatus, Massa Medicata Fermentata) 15, Fructus Amomi 13, Semen Nelumbinis 12, Radix Ophiopogonis 5, Fructus Corni 15, Crinis Carbonisatus 15.
3. according to the leukemic Chinese medicine composition of the treatment of claim 1 or 2, described preparation is a pill, powder, capsule, tablet, oral liquid.
4. according to the preparation method of the leukemic Chinese medicine composition of treatment of claim 3, it is characterized in that making with each crude drug pulverize separately, mixing, according to a conventional method preparation.
5. according to the preparation method of the leukemic Chinese medicine composition of treatment of claim 4, it can also be to get above-mentioned raw materials medicine component, and pulverize separately, mixing are made standby loosing; In addition add proper honey and go into pot and be fried boiling, take out and filter, reenter pot and be fried boiling, add appropriate amount of purified water again and put in the Mel pot that is fried boiling and be fried boiling 1-3 minute, more standby loosing slowly gone into pot and stirred evenly, take out pill by standby diffusing quantity.
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| CN101214320B (en) * | 2008-01-07 | 2011-01-19 | 姚万英 | Medicament for treating leukemia and preparation thereof |
| CN104689087A (en) * | 2015-03-03 | 2015-06-10 | 山东凤鸣堂医药科技有限公司 | Traditional Chinese medicine composition for treating leukemia and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1125617A (en) * | 1995-09-15 | 1996-07-03 | 仇殿明 | Medicine for treatment of aplastic anemia and its preparation method |
| CN1260983A (en) * | 1999-01-21 | 2000-07-26 | 仇殿明 | Process for preparing leukemia medicines |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1125617A (en) * | 1995-09-15 | 1996-07-03 | 仇殿明 | Medicine for treatment of aplastic anemia and its preparation method |
| CN1260983A (en) * | 1999-01-21 | 2000-07-26 | 仇殿明 | Process for preparing leukemia medicines |
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