CN104940505A - 一种用于治疗慢性胰腺炎的中药 - Google Patents
一种用于治疗慢性胰腺炎的中药 Download PDFInfo
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Abstract
本发明涉及一种用于治疗慢性胰腺炎的中药，它是由以下重量配比的原料药材制备而成：桂枝5份、炒白芍6份、红藤8份、败酱草9份、银柴胡8份、炒当归6份、雪莲5份、制香附5份。临床实验证明，本发明能够安全有效治疗慢性胰腺炎。
Description
技术领域
本发明涉及一种中药，具体涉及一种用于治疗慢性胰腺炎的中药。
背景技术
定义
慢性胰腺炎是由于胆道疾病或酒精中毒等因素导致的胰腺实质进行性损害和纤维化，常伴钙化、假性囊肿及胰岛细胞减少或萎缩。主要表现为腹痛、消瘦、营养不良、腹泻或脂肪痢，后期可出现腹部包块、黄疸和糖尿病等。
病因
慢性胰腺炎，主要由梗阻、过量饮酒、暴饮暴食所引起。中医认为慢性胰腺炎属于胃心痛的疾病范畴，属厥心痛之一。由胃病邪上乘心所致的心痛。证见腹胀胸满，胃脘当心痛。《灵枢·厥病》：“厥心痛，腹胀胸满，心尤痛甚，胃心痛也。”《三因极一病证方论》卷九：“胃心痛者，腹胀满，不下食，食则不消。”《张氏医通·诸痛门》谓：胃心痛多由停滞，治宜通滞理气。
症状
1.腹痛
是主要临床症状。腹痛剧烈，起始于中上腹，也可偏重于右上腹或左上腹，放射至背部。累及全胰则呈腰带状向腰背部放射痛。饮酒诱发的胰腺炎常在醉酒后12～48小时期间发病，出现腹痛。胆源性胰腺炎常在饱餐之后出现腹痛。
2.恶心、呕吐常与腹痛伴发
呕吐剧烈而频繁。呕吐物为胃十二指肠内容，偶可伴咖啡样内容。
3.腹胀
早期为反射性肠麻痹，严重时可由腹膜后蜂窝织炎刺激所致。邻近胰腺的上段小肠和横结肠麻痹扩张。腹胀以上腹为主，腹腔积液时腹胀更明显，病人排便、排气停止，肠鸣音减弱或消失。
4.腹膜炎体征
水肿性胰腺炎时，压痛只限于上腹部，常无明显肌紧张。出血坏死性胰腺炎压痛明显，并有肌紧张和反跳痛，范围较广或延及全腹。
本发明所涉及药材研究现状如下：
桂枝【来源】本品为樟科植物肉桂Cinnamomum cassia Presl的干燥嫩枝。春、夏二季采收，除去叶，晒干，或切片晒干。【性味】辛、甘，温。【归经】归心、肺、膀胱经。【功能主治】发汗解肌，温通经脉，助阳化气，平冲降气。用于风寒感冒，脘腹冷痛，血寒经闭，关节痹痛，痰饮，水肿，心悸，奔豚。【用法用量】3～9g。
白芍【来源】本品为毛茛科植物芍药Paeonia lactiflora Pall.的干燥根。夏、秋二季采挖，洗净，除去头尾及细根，置沸水中煮后除去外皮或去皮后再煮，晒干。【性味】苦、酸，微寒。【归经】归肝、脾经。【功能主治】平肝止痛，养血调经，敛阴止汗。用于头痛眩晕，胁痛，腹痛，四肢挛痛，血虚萎黄，月经不调，自汗，盗汗。【用法用量】6～15g。【注意】不宜与藜芦同用。
红藤：【来源】本品为木通科植物大血藤Sargentodoxa cuneata(Oliv.)Rehd.et Wils.的干燥藤茎。秋、冬二季采收，除去侧枝，截段，干燥。【性味】苦，平。【归经】归大肠、肝经。【功能主治】清热解毒，活血，祛风。用于肠痈腹痛，经闭痛经，风湿痹痛，跌扑肿痛。【用法用量】6～15g。
败酱草【来源】本品为败酱草科植物黄花龙芽Patriniascabiosaefolia Fisch.ex Link.，白花败酱(苦斋)P.villosa(Thunb.)Juss.，以根状茎和根、全草入药。根春秋季节采挖，去掉茎叶洗净，晒干。全草夏秋采割，洗净晒干。【性味】辛、苦，凉。【归经】入胃、大肠、肝经。【功能主治】清热解毒，消痈排脓，活血行瘀。用于肠痈、肺痈及疮痈肿毒，实热瘀滞所致的胸腹疼痛，产后瘀滞腹痛等症。【用法用量】6～15g。
银柴胡【来源】本品为石竹科繁缕属植物银柴胡Stellariadichotoma L.var.lanceolata Bge.的干燥根。春、夏间植株萌发或秋后茎叶枯萎时采挖；栽培品于种植后第三年9月中旬或第四年4月中旬采挖，除去残茎、须根及泥沙，晒干。【性味】甘，微寒。【归经】归肝、胃经。【功能主治】清虚热，除疳热。用于阴虚发热，骨蒸劳热，小儿疳热。【用法用量】3～9g。
当归【来源】本品为伞形科植物当归Angelica sinensis(Oliv.)Diels的干燥根。秋末采挖，除去须根及泥沙，待水分稍蒸发后，捆成小把，上棚，用烟火慢慢熏干。【性味】甘、辛，温。【归经】归肝、心、脾经。【功能主治】补血活血，调经止痛，润肠通便。用于血虚萎黄，眩晕心悸，月经不调，经闭痛经，虚寒腹痛，肠燥便秘，风湿痹痛，跌扑损伤，痈疽疮疡。酒当归活血通经。用于经闭痛经，风湿痹痛，跌扑损伤。【用法用量】6～12g。
雪莲【来源】菊科风毛菊属植物绵头雪莲花Saussurea lanicepsHand.-Mazz.和毛头雪莲花S.eriocephala Franch，以带根全草入药。夏季采收，全株拔起，抖净泥沙，晾干。【性味】甘、微苦，温。【功能主治】补肾壮阳，调经止血。用于雪盲，牙痛，风湿性关节炎，阳痿，月经不调，崩漏，白带；外用治创伤出血。【用法用量】3～5g。
香附【来源】本品为莎草科植物莎草Cyperus rotundus L.的干燥根茎。秋季采挖，燎去毛须，置沸水中略煮或蒸透后晒干，或燎后直接晒干。【性味】辛、微苦、微甘，平。【归经】归肝、脾、三焦经。【功能主治】行气解郁，调经止痛。用于肝郁气滞，胸、胁、脘腹胀痛，消化不良，胸脘痞闷，寒疝腹痛，乳房胀痛，月经不调，经闭痛经。【用法用量】3～9g。
发明内容
本发明旨在提供一种用于治疗慢性胰腺炎的中药，通过选择合适的药材及其配比，达到安全有效治愈慢性胰腺炎的目的。
为了达到上述目的，本发明采用以下技术方案：
一种用于治疗慢性胰腺炎的中药，其特征在于，它是由以下重量配比的原料药材制备而成：桂枝5份、炒白芍6份、红藤8份、败酱草9份、银柴胡8份、炒当归6份、雪莲5份、制香附5份。
发明人认为胃心痛为寒邪客胃，留滞胸胁腕腹，另体质久病偏需，寒邪凝滞，气机不畅则发为胃心痛。故组配本方。
下面结合临床实验数据说明本发明的有益效果：
1、一般资料
发明人于2012年9月～2013年2月间共收集门诊及住院慢性胰腺炎患者64例，随机分为2组，治疗组42例，男18例，女24例。平均年龄47岁；病程15天-7年，平均13个月。对照组22例，男10例，女12例，年龄27-60岁，平均45岁；病程27天-6年，平均1年。两组性别、年龄及病程比较差异无统计学意义，具有可比性。
2、试验方法
治疗组口服本发明按照具体实施例1制得的煎剂，每日3次。疗程2周。
对照组用青霉素钠(国药准字H37020586，山东鲁抗医药股份有限公司)每日1次静点，1200万单位，连续用2周，多酶片每日3次，每次3片口服2周。
3、治疗结果
疗效标准
痊愈：临床症状体征完全消失饮食正常，显效：主要临床症状体征消失，少食肥甘厚味，好转：主要临床症状体征减轻，忌食肥甘，无效：二临床症状体征无明显变化，忌食肥甘。
治疗组治愈例数20例，显效12例，好转7例，无效3例，总有效率为93.0％；对照组治愈0例，显效4例，好转5例，无效13例，总有效率为40.2％。两组有效率比较存在显著差异，P＜0.05。
可见，本发明制得的药物能够安全有效治疗慢性胰腺炎，具有推广价值。
具体实施方式
为了更好地理解和实施本发明，下面结合具体实施例进一步说明本发明。
具体实施例1
称取：桂枝5克、炒白芍6克、红藤8克、败酱草9克、银柴胡8克、炒当归6克、雪莲5克、制香附5克；将以上药材加6倍量水，煎煮1.5小时，过滤；滤渣加6倍量水，煎煮1小时，过滤；合并滤液，浓缩至120克，即得符合正常成人一天用量的煎剂。
用于治疗慢性胰腺炎。口服，每日分早中晚三次服用。
具体实施例2
称取：桂枝5克、炒白芍6克、红藤8克、败酱草9克、银柴胡8克、炒当归6克、雪莲5克、制香附5克；将以上药材加6倍量水，煎煮1小时，过滤；滤渣加10倍量水，煎煮2小时，过滤，合并滤液，浓缩，干燥，包装，即得符合正常成人一天用量的散剂。
用于治疗慢性胰腺炎。口服，每日服用一次。
具体实施例3
称取：桂枝5克、炒白芍6克、红藤8克、败酱草9克、银柴胡8克、炒当归6克、雪莲5克、制香附5克；将以上药材加6倍量水，煎煮1小时，过滤；滤渣加6倍量水，煎煮3次，每次煎煮1小时，合并煎煮液，浓缩，干燥，装入胶囊壳，即得符合正常成人一天用量的胶囊剂。
用于治疗慢性胰腺炎。口服，每日分早晚两次服用。
Claims (1)
1.一种用于治疗慢性胰腺炎的中药，其特征在于，它是由以下重量配比的原料药材制备而成：桂枝5份、炒白芍6份、红藤8份、败酱草9份、银柴胡8份、炒当归6份、雪莲5份、制香附5份。
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| CN103989875A (zh) * | 2014-05-22 | 2014-08-20 | 徐希印 | 一种用于治疗慢性胰腺炎的中药及其制备方法 |
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