CN104940250A - Extract for specific complexing and decorporation or cleaning of rare-earth metals in transition elements and extraction method of extract - Google Patents
Extract for specific complexing and decorporation or cleaning of rare-earth metals in transition elements and extraction method of extract Download PDFInfo
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- CN104940250A CN104940250A CN201410110614.5A CN201410110614A CN104940250A CN 104940250 A CN104940250 A CN 104940250A CN 201410110614 A CN201410110614 A CN 201410110614A CN 104940250 A CN104940250 A CN 104940250A
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Abstract
The invention relates to a preparation technology for complexing and decorporation medicines, in particular to an extract for specific complexing and decorporation or cleaning of rare-earth metals in transition elements and an extraction method of the extract. The method comprises the following steps: with oriental arborvitae of cupressaceae and redwood heartwood as extraction materials, leaching with alkalescent water or leaching with alcohol, and recovering the leaching solvent, wherein the extracted components comprise tropolone, resin and volatile essential oil. The extract can be applied to complexing and decorporation medicines or illuminated wound cleaning medicines for personnel who are contaminated by radioactive rare-earth metals in the transition elements and other metals such as ruthenium, rhodium and palladium, and can also be applied to a complexing agent for cleaning and recovering radioactive experimental sites.
Description
Technical field
The present invention relates to the technology of preparing of complexation decorporation medicine, be specifically related to a kind of extract for the special complexation decorporation of transition elements middle rare earth metal or cleaning and extracting method thereof.
Background technology
Test effective anti-radiation decorporation with it mice and produce medicine and about have kind more than 500 at present both at home and abroad, but mainly sodium carbonate, quinoline propylhomoserin, amino acids and aminoalkyl phosphinic acid class chelating agent, these chemical synthetic drugs are mainly not strong to the specificity of decorporation element, toxic and side effects is too large, effective acting time is short, and main cause is that chemicals is tired not high through some anti-radiation of clinical trial.Decorporation medicine for transition elements is less especially, the present invention utilizes the tall and erect phenolic ketone of the chemical composition extracted in natural drug to the rare earth metal in transition elements as radioactive technetium and other non radioactive element such as ruthenium, rhodium, palladium etc. carry out special complexation decorporation, and with in human body during rare earth metal complexation decorporation, complexation is not carried out with some trace element in body such as Ca, Zn, enzymes metabolism relevant with trace element in human body can not be caused not normal, occur decorporation syndrome.
Summary of the invention
The object of the invention is the defect for existing non-complexed drug technology, there is provided a kind of extract from Chinese medicinal plant can with the extract of rare earth metal (as radioactive technetium and other non radioactive element ruthenium, rhodium, palladium etc.) the special complexation in transition elements and extracting method thereof, as the cleaning medicine that inner transition element non-complexed drug or people's body surface transition elements of human body are polluted, also can be used as in environment by the abluent that transition elements technetium, ruthenium, rhodium, palladium pollute.
Technical scheme of the present invention is as follows: a kind of extract for the special complexation decorporation of transition elements middle rare earth metal or cleaning, extract from the Cacumen Platycladi or redwood heartwood of Cupressaceae, its composition comprises tall and erect phenolic ketone, resin and volatile spirits, and wherein the mass content of tall and erect phenolic ketone is about about 10%.
An extracting method for said extracted thing, comprises the steps:
(1) wood powder by 2mm sieve is prepared into after Cacumen Platycladi or redwood heartwood pulverizer being pulverized;
(2) wood powder is used weak caustic solution decocting in water, decocting in water thing is concentrated, deep with 90% alcohol, reclaim alcohol after filtration;
(3) by concentrate water dissolution, Sal is added to saturated, with chloroform extraction after saturated;
(4) chloroform is reclaimed to chloroformic solution, then by polyamide column, water elution;
(5) carry out crystallization to water elution liquid, this crystal is for slightly to carry tall and erect phenolic ketone, and residue continues to repeat to extract crystallization;
(6) crystal infrared spectrum and NMR (Nuclear Magnetic Resonance) spectrum are identified;
(7) in vitro tall and erect phenolic ketone and transition elements middle rare earth metal are carried out complex reaction, and utilize ultraviolet or infrared spectrophotometer to measure with the growing amount of accurate Calculation complex reaction thing to reaction color.
Beneficial effect of the present invention is as follows: the invention provides based on the tall and erect phenolic ketone of Chinese medicine with the medicine of the special complexation decorporation such as transition elements middle rare earth metal technetium, ruthenium, rhodium, palladium or cleaning, there is following obvious advantage compared with traditional compound medicine:
(1) tall and erect phenolic ketone can with the special complexations such as transition elements middle rare earth metal technetium, ruthenium, rhodium, palladium, with other trace element not complexation in human body, overcome the defect of other metal complex in traditional chelating agent such as picture EDTA and body, avoid in human body because the trace element that human body when complexed transition element middle rare earth metal technetium, ruthenium, rhodium, palladium is necessary is occurred trace element deficiency syndrome by complexation simultaneously;
(2) during the special complexation such as tall and erect phenolic ketone and transition elements middle rare earth metal technetium, ruthenium, rhodium, palladium, different element can show different colors, by spectrophotometer, quantitative and qualitative analysis is carried out to display different colours, the exposure dose be subject in human body can be estimated;
(3) because tall and erect phenolic ketone medicine source comes from pure Chinese medicine extract, so toxic and side effects is little;
(4) metabolism is very fast in vivo for tall and erect phenolic ketone, because it has special functional group, with aobvious acid in vivo, soluble in water during the special complexation decorporation such as transition elements middle rare earth metal technetium, ruthenium, rhodium, palladium, so not easily accumulation in organ, tissue;
(5) tall and erect phenolic ketone can simultaneously for the wound complexing cleaning of transition elements middle rare earth metal radioactive technetium and ruthenium, rhodium, palladium equivalent damage, and can judge the degree of cleaning wound as the biological effect index of sensitivity according to its color reaction.
Accompanying drawing explanation
Fig. 1 is method flow diagram of the present invention.
Detailed description of the invention
Below in conjunction with accompanying drawing and implementation process, the present invention is described in detail.
The medicine that the present invention will protect is Chinese medicine; the tall and erect phenolic ketone of main extract component; this composition comes from (cup essaceae) Cacumen Platycladi and the redwood Heartwood extracts of Cupressaceae; the element of the first species is also had to be resin and volatile spirits etc.; the tall and erect phenolic ketone of main component wherein has complexing to human body inner transition element middle rare earth metal technetium, ruthenium, rhodium, palladium; can be used as transition elements middle rare earth metal technetium, ruthenium, rhodium, the palladium decorporation medicine of human body, for interior decorporation medicine or by shining cleaning wound medicine.
As shown in Figure 1, from Chinese herbal medicine, extract the tall and erect phenol ketonic compound of single note extraction process and extracting method are as follows:
(1) wood powder by 2mm sieve is prepared into after Cacumen Platycladi or redwood heartwood pulverizer being pulverized;
(2) wood powder is used weak caustic solution decocting in water, decocting in water thing is concentrated, deep with 90% alcohol, reclaim alcohol after filtration;
(3) by concentrate water dissolution, Sal is added to saturated, with chloroform extraction after saturated;
(4) chloroform is reclaimed to chloroformic solution, then by polyamide column, water elution;
(5) carry out crystallization to water elution liquid, this crystal is for slightly to carry tall and erect phenolic ketone, and residue continues to repeat to extract crystallization;
(6) crystal infrared spectrum and NMR (Nuclear Magnetic Resonance) spectrum are identified;
(7) in vitro tall and erect phenolic ketone and transition elements middle rare earth metal are carried out complex reaction, and utilize ultraviolet or infrared spectrophotometer to measure with the growing amount of accurate Calculation complex reaction thing to reaction color.
Although tall and erect phenolic ketone is extremely strong to complexing powers such as transition elements middle rare earth metal radioactive technetium and ruthenium, rhodium, palladiums, most research all concentrates on anti-diabetic and the bactericidal antiphlogistic aspect of tall and erect phenolic ketone.Have 6 pi-electrons at the phenolic ketone ring of tall and erect phenolic ketone molecule, have the armaticity of similar phenyl, but not there is the representativeness of carbonyl and double bond, and its hydroxyl has the character similar to phenolic hydroxyl group.Exactly because tall and erect phenolic ketone molecule has a phenolic hydroxyl group and faces the strong suction tall and erect phenolic ketone electron group carbonyl of position, molecule has stable quinoid structure, carbonyl in molecule is similar to carbonyl in carboxylic acid, but can not react with general carbonyl reagent, so lonely right valency electron can be provided as good part,, and seven yuan of aromatic rings that itself is formed, be a special functional group.Transition elements middle rare earth metal radioactive technetium and ruthenium, rhodium, palladium plasma all has sky valence orbit 4d, 5s, all belong to the track of same energy level group, be conducive to forming the stronger hybrid orbital of various bonding power to accept the electron pair of ligand, thus its polarization is stronger than corresponding major element ion, the unsaturation (underfill) of its structure makes it have again larger morphotropism (polarizability), these factors facilitate transition elements middle rare earth metal radioactive technetium and ruthenium, rhodium, palladium ion is the fabulous centrosome of list of coordination units, these particularitys make tall and erect phenolic ketone can with transition elements middle rare earth metal radioactive technetium and ruthenium, rhodium, palladium is combined closely.Because transition elements middle rare earth metal radioactive technetium and ruthenium, rhodium, these elements have not paired single electron on their d track, the excited state of these electronics and the energy comparison of ground state close, as long as generally have visible ray that them just can be made to excite, add tall and erect phenolic ketone and have special colour developing functional group, so the crystal formed during their complexations all easily shows chromatic colour, the depth according to each thing color of shown network can measure complexing power, carries out complexation and qualification to the species type of human body skin, wound contamination simultaneously.
The present invention can be used for complexation decorporation medicine and the cleaning wound medicine that transition elements middle rare earth metal radioactive technetium and ruthenium, rhodium, palladium etc. pollute personnel, also can be used for the clean recovery chelating agent of experimental site.
Obviously, those skilled in the art can carry out various change and modification to the present invention and not depart from the spirit and scope of the present invention.Like this, if these amendments of the present invention and modification belong within the scope of the claims in the present invention and equivalent technology thereof, then the present invention is also intended to comprise these change and modification.
Claims (2)
1. the extract for the special complexation decorporation of transition elements middle rare earth metal or cleaning, it is characterized in that: extract from the Cacumen Platycladi or redwood heartwood of Cupressaceae, its composition comprises tall and erect phenolic ketone, resin and volatile spirits, and wherein the mass content of tall and erect phenolic ketone is about about 10%.
2. an extracting method for extract described in claim 1, comprises the steps:
(1) wood powder by 2mm sieve is prepared into after Cacumen Platycladi or redwood heartwood pulverizer being pulverized;
(2) wood powder is used weak caustic solution decocting in water, decocting in water thing is concentrated, deep with 90% alcohol, reclaim alcohol after filtration;
(3) by concentrate water dissolution, Sal is added to saturated, with chloroform extraction after saturated;
(4) chloroform is reclaimed to chloroformic solution, then by polyamide column, water elution;
(5) carry out crystallization to water elution liquid, this crystal is for slightly to carry tall and erect phenolic ketone, and residue continues to repeat to extract crystallization;
(6) crystal infrared spectrum and NMR (Nuclear Magnetic Resonance) spectrum are identified;
(7) in vitro tall and erect phenolic ketone and transition elements middle rare earth metal are carried out complex reaction, and utilize ultraviolet or infrared spectrophotometer to measure with the growing amount of accurate Calculation complex reaction thing to reaction color.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103565852A (en) * | 2012-12-26 | 2014-02-12 | 中国辐射防护研究院 | Traditional Chinese medicine extract for irradiated body radionuclide excretion promotion and extraction method of traditional Chinese medicine extract |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103565852A (en) * | 2012-12-26 | 2014-02-12 | 中国辐射防护研究院 | Traditional Chinese medicine extract for irradiated body radionuclide excretion promotion and extraction method of traditional Chinese medicine extract |
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Application publication date: 20150930 |