CN104931440B - A kind of Portable heavy metal high-sensitivity detection device based on micro-fluidic chip - Google Patents

A kind of Portable heavy metal high-sensitivity detection device based on micro-fluidic chip Download PDF

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CN104931440B
CN104931440B CN201510321422.3A CN201510321422A CN104931440B CN 104931440 B CN104931440 B CN 104931440B CN 201510321422 A CN201510321422 A CN 201510321422A CN 104931440 B CN104931440 B CN 104931440B
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micro
fluidic chip
sample
heavy metal
injection port
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CN104931440A (en
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汪六三
王儒敬
鲁翠萍
汪玉冰
宋良图
张正勇
高钧
刘洋
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Hefei Institutes of Physical Science of CAS
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Hefei Institutes of Physical Science of CAS
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Abstract

The present invention provides a kind of Portable heavy metal high-sensitivity detection device based on micro-fluidic chip, and the device includes sample injection unit, micro-fluidic chip, recovery unit, absorption spectrum detection unit and control and data processing display unit;The sample injection unit includes reagent storage means, blank solution storage device, sample storage device, miniature electromagnetic valve, the first minisize electromagnetic pump and the second minisize electromagnetic pump;The micro-fluidic chip includes the first injection port, the second injection port, sense channel and outlet;The recovery unit includes waste liquid storage device;The absorption spectrum detection unit includes light source, optical resonator and micro spectrometer;The control includes control circuit and terminal device with data processing display unit.The present invention can realize that the quick, real-time of heavy metal, in site measurement and detection sensitivity are high;The present invention device integrated level height, small volume, it is in light weight, be easy to carry, be easy to operate.

Description

A kind of Portable heavy metal high-sensitivity detection device based on micro-fluidic chip
Technical field
The present invention relates to heavy metal analysis technical field, specifically a kind of Portable heavy metal based on micro-fluidic chip is high Sensitivity detector.
Background technology
In recent years, heavy metal pollution event in China's takes place frequently, the Guangdong north Jiang Shaoguan section cadmium severe overweight events of such as 2005, The Hunan Xiang River Zhuzhou section cadmium pollution event of 2006, the liuyang hunan cadmium pollution accident of 2009, the Wugang City of Hunan in 2009 Hundreds children blood lead is exceeded, tens of of Qingyuan City In Guangdong Province children's lead poisoning, Qujing of Yunnan pollution of chromium event in 2011,2012 Guangxi Hechi Longjiang river cadmium pollution event etc..Therefore, it is necessary to quick, the real-time, method of in situ detection heavy metal and instrument.Mesh Before, the method for heavy metal analysis mainly has spectroscopic methodology, electrochemical process and new detection technique etc..
Spectroscopic methodology is the traditional method of comparison, mainly there is atomic absorption spectrophotometry(AAS), inductively coupled plasma Emission spectrometry(ICP-AES), inductively coupled plasma mass spectrometry(ICP-MS), ultraviolet spectrophotometry etc..These methods Have the characteristics that detection sensitivity is high, detection range is wide and favorable reproducibility, still, instrument and equipment volume needed for these methods it is big and It is expensive.Electrochemical process is popular detection method, including voltammetry, polarography, potentiometry etc. at present, detection Speed is fast, and accuracy of detection is higher, but has much room for improvement in terms of coexisting ion interferometry.In addition, relatively new type detection method There are enzyme sensor method, hexavalent chrome bio-removal etc., enzymatic activity is influenceed very big by environmental change, and accuracy of detection is difficult to ensure that, and is given birth to The detection time of thing sensor is general longer.
Micro-fluidic chip is that one kind uses fine processing technique, on several square centimeters of substrate, produce microchannel net Network structure and other functional units, to realize collection micro-example preparation, sample introduction, reaction, separate and be detected on integral quick, high Effect, the micro-analysis detection means of low consumption.The detection method of micro-fluidic chip mainly has optical means and electrochemical method.Due to Optical means is relatively simple and high sensitivity, application of this method in micro-fluidic chip are very extensive.At present, micro-fluidic chip light Learning detection method mainly has absorption spectrometry, fluorescent spectrometry, chemoluminescence method.Absorption spectrometry is applied generally in the detection, And it is suitable for the detection of heavy metal, but it is short due to absorbing light path in micro-fluidic chip, cause detection sensitivity low.
The content of the invention
It is an object of the invention to provide a kind of Portable heavy metal high-sensitivity detection device based on micro-fluidic chip, Overcome the shortcomings of existing heavy metal it is quick, in real time, in situ detection.
The technical scheme is that:
A kind of Portable heavy metal high-sensitivity detection device based on micro-fluidic chip, the device include sample injection unit, Micro-fluidic chip, recovery unit, absorption spectrum detection unit and control and data processing display unit;
The sample injection unit include reagent storage means, blank solution storage device, sample storage device, miniature electromagnetic valve, First minisize electromagnetic pump and the second minisize electromagnetic pump;The micro-fluidic chip includes the first injection port, the second injection port, detects and lead to Road and outlet;The recovery unit includes waste liquid storage device;The absorption spectrum detection unit includes light source, optical resonance Chamber and micro spectrometer;The control includes control circuit and terminal device with data processing display unit;
The reagent storage means and blank solution storage device pass sequentially through miniature electromagnetic valve and the first minisize electromagnetic pump It is connected with the first injection port, the sample storage device is connected by the second minisize electromagnetic pump with the second injection port, and described first Injection port and the second injection port are connected by sense channel with outlet, and the outlet connects with waste liquid storage device;
The optical resonator is integrated on micro-fluidic chip, by two panels be arranged symmetrically in sense channel both sides and close to go out The mirror-reflection piece of sample mouth is formed;The output end of the light source and the input of optical resonator connect, the optical resonator Output end and the input of micro spectrometer connect, the input of the output end of the micro spectrometer and terminal device connects Connect;The output end of the terminal device is miniature with miniature electromagnetic valve, the first minisize electromagnetic pump and second respectively by control circuit The input connection of electromagnetic pump.
The described Portable heavy metal high-sensitivity detection device based on micro-fluidic chip, it is single that the device also includes power supply Member, said supply unit use 12V lithium batteries, are miniature electromagnetic valve, the first minisize electromagnetic pump, the second minisize electromagnetic pump and terminal Equipment provides working power.
The described Portable heavy metal high-sensitivity detection device based on micro-fluidic chip, the device are also consolidated including chip Determine frame, the micro-fluidic chip is screwed on chip fixing bracket.
The described Portable heavy metal high-sensitivity detection device based on micro-fluidic chip, the micro-fluidic chip also wrap Filter membrane is included, the filter membrane is integrated on the second injection port.
The described Portable heavy metal high-sensitivity detection device based on micro-fluidic chip, the micro-fluidic chip use PMMA is prepared, and its length is 50mm, width 20mm, is from bottom to top divided into five layers, wherein, the thickness of first layer is 500um, the thickness of the second layer are 55um, and the thickness of third layer is 300um, and the 4th layer of thickness is 55um, the thickness of layer 5 For 500um;First injection port, the second injection port and outlet are arranged at layer 5, and the sense channel is arranged on Three layers, the two panels mirror-reflection piece is separately positioned on the second layer and the 4th layer.
The described Portable heavy metal high-sensitivity detection device based on micro-fluidic chip, the sense channel is by sample introduction Passage, hybrid channel and sample output passage are sequentially connected composition, and the sample intake passage is Y type passages, and the hybrid channel is snakelike Passage, the sample output passage are linear pattern passage;The sample intake passage and the width of hybrid channel are 200um, and depth is 200um, the width of the sample output passage is 300um, depth 300um;The length of the hybrid channel is 25mm.
The described Portable heavy metal high-sensitivity detection device based on micro-fluidic chip, the mirror-reflection piece use Enhanced specular reflectivity piece.
Beneficial effects of the present invention are:
(1)Microflow control technique and chromogenic reaction are combined by the present invention, can not only be realized to contents of many kinds of heavy metal ion Automatic detection, test dose is few, and the selectivity of heavy metal ion is high, and interference is few, suitable for environmental sample Detection;
(2)Microflow control technique is combined by the present invention with wideband cavity reinforced absorption spectrum technology, improves detection sensitivity, And set of device can detect contents of many kinds of heavy metal ion;
(3)Mirror-reflection piece is integrated in micro-fluidic chip by the present invention, improves the stability of device, it is humorous to eliminate optics Shake the regulation of chamber;
(4)It is device integrated level height of the present invention, small volume, in light weight, it is easy to carry, it is easy to operate, it can be achieved to much money Quick, the real-time, in site measurement of category.
Brief description of the drawings
Fig. 1 is the structural representation of the present invention;
Fig. 2 is Y type micro-fluidic chip schematic diagrames;
Fig. 3 is Y type micro-fluidic chip Rotating fields schematic diagrames.
Embodiment
Below in conjunction with the accompanying drawings the present invention is further illustrated with specific embodiment.
As shown in Figure 1 and Figure 2, a kind of Portable heavy metal high-sensitivity detection device based on micro-fluidic chip, including enter Sample unit 1, Y types micro-fluidic chip 2, recovery unit 3, absorption spectrum detection unit 4, control with data processing display unit 5 and Power supply unit 6.
Sample injection unit 1 includes reagent holding bottle 11, blank solution holding bottle 12, sample storage bottle 13, miniature electromagnetic valve 14, the One minisize electromagnetic pump 15 and the second minisize electromagnetic pump 16.Y types micro-fluidic chip 2 is screwed on chip fixing bracket 20, Including the first injection port 21, the second injection port 22, filter membrane 23, sample intake passage 24, snakelike hybrid channel 25, the and of sample output passage 26 Outlet 27, filter membrane 23 are integrated on the second injection port 22.Recovery unit 3 includes waste liquid holding bottle 31.
Absorption spectrum detection unit 4 includes white LED light source 41, optical resonator 42 and micro spectrometer 43, and optics is humorous The chamber 42 that shakes is integrated on Y types micro-fluidic chip 2, by two panels enhanced specular reflectivity piece(ESR)421 are formed.At control and data Reason display unit 5 includes control circuit 51 and terminal device 52, and terminal device 52 can be notebook computer or palm PC etc.; Power supply unit 6 includes battery 61, and battery 61 is 12V lithium batteries.
Reagent holding bottle 11 is used to deposit heavy metal colour reagent, and blank solution holding bottle 12 is used to deposit deionized water, sample Product holding bottle 13 is used to deposit heavy metal solution to be measured.Reagent holding bottle 11 and blank solution holding bottle 12 pass sequentially through micro electric The minisize electromagnetic pump 15 of magnet valve 14 and first is connected with the first injection port 21, sample storage bottle 13 by the second minisize electromagnetic pump 16 with Second injection port 22 connects.The entrance of first injection port 21 and the second injection port 22 with sample intake passage 24 connects, sample intake passage 24 outlet passes sequentially through snakelike hybrid channel 25 and sample output passage 26 connects with outlet 27, outlet 27 and waste liquid holding bottle 31 connections.
Y types micro-fluidic chip 2 is made using PMMA as making material using the photoetching of standard and lithographic technique.Such as Fig. 3 institutes Show, the length of Y types micro-fluidic chip 2 of the invention is 50mm, width 20mm, is divided into five layers:First layer 2-1 thickness is 500um, the second layer 2-2 thickness are 55um, and third layer 2-3 thickness is 300um, and the 4th layer of 2-4 thickness is 55um, the 5th Layer 2-5 thickness is 500um.
First injection port 21, the second injection port 22 and outlet 27 are arranged at layer 5 2-5, and the thickness of filter membrane 23 is 32um.Third layer 2-3 is channel layer, including sample intake passage 24, snakelike hybrid channel 25 and sample output passage 26, sample intake passage 24 are Y type passages, it is insertion, sample output passage 26 and outlet between the injection port 21 of sample intake passage 24 and first and the second injection port 22 It is insertion between 26;The length of snakelike hybrid channel 25 is 25mm;The width of sample output passage 26 is 300um, and depth is 300um, the width of rest channels is 200um, depth 200um.
Two panels enhanced specular reflectivity piece 421 is integrated in second layer 2-2 and the 4th layer of 2-4 respectively, is symmetricly set on out sample The both sides of passage 26 are simultaneously set close to the outlet of sample output passage 26, are had between enhanced specular reflectivity piece 421 and sample output passage 26 A thin layer PMMA intervals, to avoid contacting with flowing through the liquid of sample output passage 26.
The light that white LED light source 41 is sent is coupled into the optics for being integrated in Y types micro-fluidic chip 2 by collimation focusing mirror Resonator 42, the focus point of light are located at the center of optical resonator 42, and light comes and goes in optical resonator 42, through optical resonance The light of chamber 42 is coupled into optical fiber, optical fiber connection micro spectrometer 43 by condenser lens.Micro spectrometer 43 records transmitted light Intensity.The control module of terminal device 52 controls miniature electromagnetic valve 14, the and of the first minisize electromagnetic pump 15 by control circuit 51 The switch of second minisize electromagnetic pump 16.The spectroscopic data that the data processing module processing micro spectrometer 43 of terminal device 52 gathers And shown on display module.Battery 61 is miniature electromagnetic valve 14, the first minisize electromagnetic pump 15, the second minisize electromagnetic pump 16, end The grade of end equipment 52 is powered.In addition to terminal device 52, other all components are respectively positioned in sensor casing 0.
The present invention operation principle be:
The minisize electromagnetic pump 15 of miniature electromagnetic valve 14 and first is first turned on, allows blank solution and colour reagent to flow into Y type miniflows Chip 2 is controlled, carries out background spectrum measurement;The second minisize electromagnetic pump 16 is then turned on, allows colour reagent and heavy metal solution to be measured Into Y types micro-fluidic chip 2, colour reagent meets with heavy metal ion to be measured at Junction on bend ahead, in snakelike hybrid channel 25 Chromogenic reaction occurs after being sufficiently mixed, generates heavy metal complex;The heavy metal complex of generation is inhaled by sample output passage 26 Spectroscopic detection unit 4 is received to detect:The light that white LED light source 41 is sent comes and goes in optical resonator 42, through flowing through Y type miniflows Control the heavy metal complex of chip 2;Gathered through the light of optical resonator 42 by micro spectrometer 43, it is molten to generate heavy metal to be measured The absorption spectrum of liquid;Terminal device 52 is analyzed and processed and shown to the absorption spectrum of background spectrum and heavy metal solution to be measured As a result.
Embodiment described above is only that the preferred embodiment of the present invention is described, not to the model of the present invention Enclose and be defined, on the premise of design spirit of the present invention is not departed from, technical side of the those of ordinary skill in the art to the present invention The various modifications and improvement that case is made, it all should fall into the protection domain of claims of the present invention determination.

Claims (5)

  1. A kind of 1. Portable heavy metal high-sensitivity detection device based on micro-fluidic chip, it is characterised in that:The device includes Sample injection unit, micro-fluidic chip, recovery unit, absorption spectrum detection unit and control and data processing display unit;
    The sample injection unit includes reagent storage means, blank solution storage device, sample storage device, miniature electromagnetic valve, first Minisize electromagnetic pump and the second minisize electromagnetic pump;The micro-fluidic chip include the first injection port, the second injection port, sense channel and Outlet;The recovery unit includes waste liquid storage device;The absorption spectrum detection unit include light source, optical resonator and Micro spectrometer;The control includes control circuit and terminal device with data processing display unit;
    The reagent storage means and blank solution storage device pass sequentially through miniature electromagnetic valve and the first minisize electromagnetic pump and One injection port is connected, and the sample storage device is connected by the second minisize electromagnetic pump with the second injection port, first sample introduction Mouth and the second injection port are connected by sense channel with outlet, and the outlet connects with waste liquid storage device;
    The optical resonator is integrated on micro-fluidic chip, and sense channel both sides are arranged symmetrically in and close to outlet by two panels Mirror-reflection piece form;The input of the output end of the light source and optical resonator connects, the optical resonator it is defeated Go out end to be connected with the input of micro spectrometer, the output end of the micro spectrometer and the input of terminal device connect;Institute State the output end of terminal device by control circuit respectively with miniature electromagnetic valve, the first minisize electromagnetic pump and the second minisize electromagnetic pump Input connection;
    The micro-fluidic chip is prepared using PMMA, and its length is 50mm, width 20mm, is from bottom to top divided into five Layer, wherein, the thickness of first layer is 500um, and the thickness of the second layer is 55um, and the thickness of third layer is 300um, the 4th layer of thickness Spend for 55um, the thickness of layer 5 is 500um;First injection port, the second injection port and outlet are arranged at layer 5, The sense channel is arranged on third layer, and the two panels mirror-reflection piece is separately positioned on the second layer and the 4th layer;
    The sense channel is sequentially connected by sample intake passage, hybrid channel and sample output passage and formed, and the sample intake passage is that Y types lead to Road, the hybrid channel are serpentine channel, and the sample output passage is linear pattern passage;The sample intake passage and the width of hybrid channel Degree is 200um, and depth is 200um, and the width of the sample output passage is 300um, depth 300um;The hybrid channel Length be 25mm.
  2. 2. the Portable heavy metal high-sensitivity detection device according to claim 1 based on micro-fluidic chip, its feature It is:The device also includes power supply unit, and said supply unit uses 12V lithium batteries, is miniature electromagnetic valve, the first micro electromagnetic Pump, the second minisize electromagnetic pump and terminal device provide working power.
  3. 3. the Portable heavy metal high-sensitivity detection device according to claim 1 based on micro-fluidic chip, its feature It is:The device also includes chip fixing bracket, and the micro-fluidic chip is screwed on chip fixing bracket.
  4. 4. the Portable heavy metal high-sensitivity detection device according to claim 1 based on micro-fluidic chip, its feature It is:The micro-fluidic chip also includes filter membrane, and the filter membrane is integrated on the second injection port.
  5. 5. the Portable heavy metal high-sensitivity detection device according to claim 1 based on micro-fluidic chip, its feature It is:The mirror-reflection piece uses enhanced specular reflectivity piece.
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