CN104922260A

CN104922260A - Medicine for treating secretory otitis media

Info

Publication number: CN104922260A
Application number: CN201510436012.3A
Authority: CN
Inventors: 刘青云
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-07-22
Filing date: 2015-07-22
Publication date: 2015-09-23

Abstract

The invention relates to medicine for treating secretory otitis media. The medicine is prepared from the following raw medicinal materials of, by weight, 12 parts of cottonrose hibiscus leaves, 12 parts of calcined concha arcae, 15 parts of trichosanthes kiritowii maxim, 30 parts of oldenlandia diffusa, 9 parts of cistanche, 9 parts of citron peel, 25 parts of sculellaria barbata and 9 parts of fortune eupatorium herb. The clinical experiment proves that the medicine can safely and effectively treat secretory otitis media.

Description

A kind of medicine being used for the treatment of secretory otitis media

Technical field

The present invention relates to a kind of Chinese medicine, be specifically related to a kind of medicine being used for the treatment of secretory otitis media.

Background technology

The middle ear apyetous disease that secretory otitis media is is principal character with middle ear effusion and auditory dysesthesia.Clinical manifestation is mainly auditory dysesthesia, can change with position chanP, slight otalgia, tinnitus, and the vexed swollen and inaccessible sense of ear, shakes the head and can hear the underwater sound.The visible otopiesis of otology training inspection, in amber or color and luster obfuscation, also visible air fluid level or bubble, tympanum mobility reduces.The traditional Chinese medical science calls it " bulge of the ear ", " deafness ".Also the title of " soldier is deaf ", " deafness due to pathogenic wind ", " deafness with qi stagnation " is had.Secretory otitis media is otorhinolaryngologic commonly encountered diseases and frequently-occurring disease, and its cause of disease and pathogenesis are very complicated, is still among further research and exploitation.It is generally acknowledged relevant with Eustachian tube disfunction, infection and immunoreation etc.At present, with regard to secretory otitis media, whether this uses Drug therapy, and uses which kind of medicine, does not also have definite scheme.In recent years, whether gastroesophageal reflux disease becomes the cause of secretory otitis media and becomes focus in the industry by gastric acid inhibitory and use gastro-kinetic agent co-treatment with the research improving the curative effect of secretory otitis media etc.There is report, in 82% middle ear transudates, have the existence of pepsinogen, use the medicine of gastric acid inhibitory and gastro-kinetic agent partner treatment to be of value to the treatment of otitis media.

Medical material present Research involved in the present invention is as follows:

Folium Hibisci Mutabilis [another name] Hibisci Mutabilis, Hibisci Mutabilis, Cortex seu Flos Hibisci taiwanenss, Folium Hibisci Mutabilis, three become flower, kapok.[source] is the leaf of Malvaceae plant Hibisci Mutabilis.Summer, autumn gather, and dry.[nature and flavor] are cool in nature, and taste is micro-pungent.[return through] lung; Liver Channel.[function cures mainly] Qingfei Liangxue, detumescence and apocenosis.For cough due to lung-heat, hypertrophic rhinitis, lymphadenitis, appendicitis, carbuncle furuncle abscess, acute otitis media, burn, scald.[usage and dosage] takes orally: decoct soup, 10 ~ 30g.[attention] anemia of pregnant woman prohibits clothes.[extracts] " China's book on Chinese herbal medicine ".

Concha Arcae (calcined) [another name] Concha Meretricis Seu Cyclinae, watt room, row of tiles on a roof, wax shell, flower Concha Corbicula fluminea, row of tiles on a roof clam skin, blood clam fur Carnis Arca inflata skin.[source] is the shell of Carnis Arca inflata section animal Scapharca broughtonii, Tegillarca granosa and Scapharca subcrenata.[nature and flavor] are salty, flat.[return through] returns lung, stomach, Liver Channel.[function cures mainly] expectorant blood stasis dispelling, hard masses softening and resolving, relieving gastric hyperacidity to alleviate stomachache.The long-pending knot of pertinacious phlegm, thickness difficulty is coughed up, goiter, scrofula, abdominal mass mass in the abdomen, stomachache pantothenic acid.[usage and dosage] takes orally: decoct soup, 9 ~ 15g.[extracts] " China's book on Chinese herbal medicine ".

Whole Fructus Trichosanthis [another name] Fructus Trichosanthis, medicine melon, Fructus Trichosanthis egg, naked, the king Bodhisattva of fruit, Di Lou, huge, the damp smelting in pool, Wang Bai, sky melon, damp aunt, Fructus Cucumidis sativi, sky dumpling made of glutinous rice flour, Fructus Kaki melon, Canis familiaris L. Fructus Momordicae charantiae, wild Fructus Momordicae charantiae, Du's melon, large tripe melon, duck dung melon, mountain gold gourd, great circle melon, hang melon.[source] is the kind of under Cucurbitaceae snake gourd.[nature and flavor] sweetness and bitterness, cold.[return through] enters lung, stomach, large intestine channel.[function cures mainly] lung moistening, reduces phlegm, eliminating stagnation, intestine moistening.Control phlegm-heat cough, the thoracic obstruction, blocked-up chest, consumptive lung disease hemoptysis, quenches one's thirst, jaundice, constipation, carbuncle from the beginning of.[usage and dosage] takes orally: decoct soup, 9 ~ 16g.[attention] Deficiency and coldness of spleen and stomach, loose stool, has cold-phlegm, damp-phlegm person unsuitable.[extracts] " China's book on Chinese herbal medicine ".

Herba Hedyotidis Diffusae [another name] Herba Hedyotidis Diffusae, tang Huang, Serpentis needle grass, Radix Picriae felterrae, two leaf humulus, spend in vain cross grass, sharp knife grass, JIAMENGCAO, Herba Otteliae Alismoidis, Serpentis Lei grass, crane SHECAO.[source] this product is the herb of Rubiaceae plants of Hedyotis Herba Hedyotidis Diffusae.Xia Qiu gathers, and cleans, using fresh herb or dry.[nature and flavor] are sweet, light, cool.[return through] enters stomach, large intestine, small intestine meridian.[function cures mainly] heat-clearing and toxic substances removing, inducing diuresis to remove edema, promoting blood circulation and stopping pain.For acute appendicitis (appendicitis), furuncle toxic swelling, jaundice due to damp-heat, the diseases such as dysuria; Furuncle carbuncle is controlled in external, venom.[usage and dosage] takes orally: decoct soup, 25 ~ 100g.[attention] anemia of pregnant woman is cautious use of.[extracts] " China's book on Chinese herbal medicine ".

Herba Cistanches [another name] dried meat floss Rong, vertical Rong, Herba Stellariae Saxatilis, Jin Sun, rues greatly.[source] this product is the fleshy stem of the dry zone scale leaf of orobanchaceae plant cistanche.Excavate when Seedling is not unearthed or is just unearthed more than spring, removing inflorescence, cutting, dries.[nature and flavor] are sweet, salty, temperature.[return through] returns kidney, large intestine channel.[function cures mainly] kidney-replenishing, benefiting essence-blood, loosening bowel to relieve constipation.For sexual impotence, infertile, soreness of the waist and knees, muscles and bones is unable, dryness of the intestine constipation.[usage and dosage] takes orally: decoct soup, 6 ~ 9g.[attention] to be had loose bowels forbidding, is had heat in kidney, strong YANG transmission Xing Erjing admittedly person avoid it.[extracts] " China's book on Chinese herbal medicine ".

Pericarpium Citri [another name] citron, hook edge are dry, pomelo tree, Fructus Citri Citrus chachiensis Hort. citron, fragrantly to justify.[source] this product is the dry mature fruit of rutaceae citron or fragrant circle (the fragrant circle in southwest).Gather during fruit maturation in autumn, take advantage of fresh slices, dry or cold drying.Fragrant circle also can be whole or to after cuing open two halves, dries or cold drying.[nature and flavor] are pungent, bitter, sour, temperature.[return through] returns liver, spleen, lung meridian.[function cures mainly] liver-smoothing, qi-regulating, alleviating distention in middle-JIAO, reduces phlegm.For stagnation of liver-QI and stomach-QI, distending pain in the chest and hypochondrium, gastral cavity abdomen feeling of fullness, vomiting eructation, abundant expectoration is coughed.[usage and dosage] takes orally: decoct soup, 3 ~ 9g.Dry and the careful clothes of anemia of pregnant woman deficiency of vital energy person of [attention] deficiency of YIN blood.[extracts] " China's book on Chinese herbal medicine ".

Herba Scutellariae Barbatae [another name] Aleuritopteris argentea (Gmel.) Fee, purple connect careless and head is careless, toothbrush grass, little Herba Scutellariae indicae, water Korea Spro letter, little scutllaria indica, small stream limit Radix Scutellariae, Herba Carpesii Divaricati, wild Spica Prunellae, Medulla Tetrapanacis youngster, half are to flower, demifacet flower, partially head grass, Rabdosia stracheyi(Benth.ex Hook.f.)Hara[Plectranthus stracheyi Benth.ex Hook.f., scutllaria indica, small size India skullcap, tiger sting red, aftergrass, Herba hyperici attenuati, narrow leaf India skullcap.[source] this product is the dry herb of labiate Herba Scutellariae Barbatae.Summer, autumn two excavate when season, stem and leaf was luxuriant, clean, dry.[nature and flavor] are pungent, bitter, cold.[return through] returns lung, liver, kidney channel.[function cures mainly] heat-clearing and toxic substances removing, blood stasis dispelling diuresis.For furuncle swelling toxin, laryngopharynx swelling and pain, venom, falls and flutters the pain of injury, edema, jaundice.[usage and dosage] takes orally: decoct soup, 15 ~ 30g.[attention] blood deficiency person is unsuitable, the careful clothes of anemia of pregnant woman.[extracts] " China's book on Chinese herbal medicine ".

Herba Eupatorii [another name] Herba Chlorophyti, Herba Lycopi, circle stalk Herba Lycopi, Ocimum basilicum L. var. pilosum.[source] this product is the dry aerial parts of feverfew Herba Eupatorii.Summer, Qiu Erji tap at twice, and removing impurity, dries.[nature and flavor] are pungent, flat.[return through] returns spleen, stomach, lung meridian.[function cures mainly] removing dampness by means of aromatics, appetizing of being amusing, delivers expelling summer-heat.For turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass vomiting and nausea, sweet greasy in mouth, halitosis, sialism, heat-damp in summer table disease, feeling of fullness in the head is uncomfortable in chest.[usage and dosage] takes orally: decoct soup, 3 ~ 9g.[attention] deficiency of YIN, deficiency of vital energy person avoid clothes.[extracts] " China's book on Chinese herbal medicine ".

Summary of the invention

The present invention aims to provide a kind of medicine being used for the treatment of secretory otitis media, by selecting suitable medical material and proportioning thereof, reaches the object of safe and effective healing secretory otitis media.

In order to achieve the above object, the present invention is by the following technical solutions:

A kind of medicine being used for the treatment of secretory otitis media, it is characterized in that, it is prepared from by the raw medicinal material of following weight proportion: Folium Hibisci Mutabilis 12 parts, Concha Arcae (calcined) 12 parts, whole Fructus Trichosanthis 15 parts, Herba Hedyotidis Diffusae 30 parts, Herba Cistanches 9 parts, Pericarpium Citri 9 parts, Herba Scutellariae Barbatae 25 parts, Herba Eupatorii 9 parts.

Below in conjunction with clinical laboratory data, beneficial effect of the present invention is described:

1, physical data

Outpatient service is collected and patients with secretory otitis media 63 example of being in hospital altogether in inventor in October, 2012 ~ 2013 between year October, be divided into treatment group 32 example and matched group 31 example at random, treatment group man 12 example, female 20 example, 2 ~ 11 years old age; Matched group man 22 example, female 9 example, 2 ~ 10 years old age.2 groups of sexes, age and course of disease comparing difference not statistically significants, have comparability.

Diagnostic criteria

Diagnostic criteria according to the meeting of national secretory otitis media clinical speciality: clinical manifestation is mainly auditory dysesthesia, can change with position chanP, slight otalgia, tinnitus, and the vexed swollen and inaccessible sense of ear, shakes the head and can hear the underwater sound.The visible otopiesis of otology training inspection, in amber or color and luster obfuscation, also visible air fluid level or bubble, tympanum mobility reduces.

1. siegle otoscopy or microscopy; 2. Impedance audiometry; 3. auripuncture or myringotomy; 4. examination of nasopharynx; 5. temporal bone high-resolution thin-layer CT.

2, test method

2.1 Therapeutic Method

The capsule that the oral the present invention for the treatment of group obtains according to specific embodiment 3, every day 2 times.It within 1 week, was 1 course for the treatment of.

The oral cefradine of matched group, 0.25g, once a day.It within 1 week, was 1 course for the treatment of.

3, criterion of therapeutical effect and therapeutic outcome

3.1 criterion of therapeutical effect

Effective: diseased region transudate disappears, auditory rehabilitation.

Effective: diseased region oozes out minimizing, audition is comparatively front to take a turn for the better.

Invalid: even diseased region oozes out unchanged increasing the weight of, auditory dysesthesia such as front or Progressive symmetric erythrokeratodermia increase the weight of.

3.2 therapeutic outcomes are in table 1.

Table 1 liang group comparitive study

Group	n	Effective	Effectively	Invalid	Total effective rate (%)	Serious adverse reaction example
							Treatment group	32	24	6	2	93.8%	0
Matched group	31	15	8	8	74.19%	0

Visible, the medicine that the present invention obtains can safe and effective treatment secretory otitis media, has promotional value.

Detailed description of the invention

In order to understand better and implement the present invention, further illustrate the present invention below in conjunction with specific embodiment.

Embodiment 1

Take: Folium Hibisci Mutabilis 12 grams, Concha Arcae (calcined) 12 grams, whole Fructus Trichosanthis 15 grams, Herba Hedyotidis Diffusae 30 grams, Herba Cistanches 9 grams, Pericarpium Citri 9 grams, Herba Scutellariae Barbatae 25 grams, Herba Eupatorii 9 grams; Add 8 times of water gagings, decoct 1.5 hours, filter; Filtering residue adds 6 times of water gagings, decocts 1 hour, filters; Merging filtrate, is concentrated into 120 grams, must meet the decoct of adult normal's one day consumption.

Be used for the treatment of secretory otitis media.Oral, every bu Morning Afternoon Evening is taken for 2 times.

Embodiment 2

Take: Folium Hibisci Mutabilis 12 grams, Concha Arcae (calcined) 12 grams, whole Fructus Trichosanthis 15 grams, Herba Hedyotidis Diffusae 30 grams, Herba Cistanches 9 grams, Pericarpium Citri 9 grams, Herba Scutellariae Barbatae 25 grams, Herba Eupatorii 9 grams; Add 10 times of water gagings, decoct 2 hours, filter; Filtering residue adds 8 times of water gagings, decocts 1.5 hours, filters; Merging filtrate, concentrated, dry, packaging, must meet the powder of adult normal's one day consumption.

Embodiment 3

Take: Folium Hibisci Mutabilis 12 grams, Concha Arcae (calcined) 12 grams, whole Fructus Trichosanthis 15 grams, Herba Hedyotidis Diffusae 30 grams, Herba Cistanches 9 grams, Pericarpium Citri 9 grams, Herba Scutellariae Barbatae 25 grams, Herba Eupatorii 9 grams; Add 6 times of water gagings, decoct 3 times, each decoction 1 hour, merges decoction liquor, concentrated, dry, incapsulates shell, must meet the capsule of adult normal's one day consumption.

Claims

1. one kind is used for the treatment of the medicine of secretory otitis media, it is characterized in that, it is prepared from by the raw medicinal material of following weight proportion: Folium Hibisci Mutabilis 12 parts, Concha Arcae (calcined) 12 parts, whole Fructus Trichosanthis 15 parts, Herba Hedyotidis Diffusae 30 parts, Herba Cistanches 9 parts, Pericarpium Citri 9 parts, Herba Scutellariae Barbatae 25 parts, Herba Eupatorii 9 parts.