CN104906647B - Displacement liquid flow matches device and flow matches method in continuous blood purification - Google Patents
Displacement liquid flow matches device and flow matches method in continuous blood purification Download PDFInfo
- Publication number
- CN104906647B CN104906647B CN201510405293.6A CN201510405293A CN104906647B CN 104906647 B CN104906647 B CN 104906647B CN 201510405293 A CN201510405293 A CN 201510405293A CN 104906647 B CN104906647 B CN 104906647B
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- 239000007788 liquid Substances 0.000 title claims abstract description 163
- 238000006073 displacement reaction Methods 0.000 title claims abstract description 89
- 210000004369 blood Anatomy 0.000 title claims abstract description 29
- 239000008280 blood Substances 0.000 title claims abstract description 29
- 238000000746 purification Methods 0.000 title claims abstract description 29
- 238000000034 method Methods 0.000 title claims abstract description 16
- 230000000844 anti-bacterial effect Effects 0.000 claims description 15
- 238000002360 preparation method Methods 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 6
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 6
- 239000011575 calcium Substances 0.000 claims description 6
- 229910052791 calcium Inorganic materials 0.000 claims description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 6
- 239000002131 composite material Substances 0.000 claims description 6
- 238000001816 cooling Methods 0.000 claims description 6
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 238000001746 injection moulding Methods 0.000 claims description 6
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 5
- 239000011777 magnesium Substances 0.000 claims description 5
- 229910052749 magnesium Inorganic materials 0.000 claims description 5
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 3
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 3
- 230000002421 anti-septic effect Effects 0.000 claims description 3
- 239000000460 chlorine Substances 0.000 claims description 3
- 229910052801 chlorine Inorganic materials 0.000 claims description 3
- 238000003780 insertion Methods 0.000 claims description 3
- 230000037431 insertion Effects 0.000 claims description 3
- 230000001050 lubricating effect Effects 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 230000004048 modification Effects 0.000 claims description 3
- 238000012986 modification Methods 0.000 claims description 3
- 238000005453 pelletization Methods 0.000 claims description 3
- 239000004014 plasticizer Substances 0.000 claims description 3
- 239000002861 polymer material Substances 0.000 claims description 3
- 239000011591 potassium Substances 0.000 claims description 3
- 229910052700 potassium Inorganic materials 0.000 claims description 3
- 230000001012 protector Effects 0.000 claims description 3
- 239000011734 sodium Substances 0.000 claims description 3
- 229910052708 sodium Inorganic materials 0.000 claims description 3
- 239000003381 stabilizer Substances 0.000 claims description 3
- 230000008859 change Effects 0.000 claims description 2
- 238000001125 extrusion Methods 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
- 238000010923 batch production Methods 0.000 abstract description 3
- 230000007774 longterm Effects 0.000 abstract description 3
- 230000008569 process Effects 0.000 abstract description 3
- 238000003860 storage Methods 0.000 abstract description 3
- 239000002585 base Substances 0.000 description 28
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 8
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 6
- 210000004185 liver Anatomy 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 5
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 4
- 238000001556 precipitation Methods 0.000 description 4
- 239000001569 carbon dioxide Substances 0.000 description 3
- 229910002092 carbon dioxide Inorganic materials 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- 230000002503 metabolic effect Effects 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 238000004080 punching Methods 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- 235000002710 Ilex cornuta Nutrition 0.000 description 1
- 241001310146 Ilex cornuta Species 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical group [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 description 1
- 235000010326 Osmanthus heterophyllus Nutrition 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- -1 can be changed Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1654—Dialysates therefor
- A61M1/1656—Apparatus for preparing dialysates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/0021—Special media to be introduced, removed or treated removed from and reintroduced into the body, e.g. after treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Emergency Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- External Artificial Organs (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The invention discloses displacement liquid flow matches device in a kind of continuous blood purification and flow matches method, the displacement liquid flow matches device includes liquid mixer and at least 2 groups dripping and leaking devices, each dripping and leaking device includes woven hose, dropper, turbine, axle and gear, wherein, the upper end of woven hose is provided with contact pin, and lower end connects with the upper end of dropper；Turbine and gear are respectively arranged on the upper and lower end of axle, turbine outer cylinder and dropper inwall inscribe；The gear external toothing of two adjacent dripping and leaking devices.The displacement liquid flow matches device that the present invention is provided can realize that real-time replacing base liquid is extracted and mixed in proportion, purpose just is prepared so as to reach, the batch production that can be standardized is prepared, reduce cost, and be avoided that the pollution of clinical configuration process, metering it is inaccurate, even wrong the problems such as, it is ensured that the inherent quality of displacement liquid, and be easy to long-term storage and transport, be conducive to quickly carrying out blood purification treatment, shorten the rescue time of critical patient.
Description
Technical field
The present invention relates to a kind of Medical Devices, and in particular to displacement liquid flow matches device in a kind of continuous blood purification
And flow matches method.
Background technology
Continuous blood purification refers to continuity and removes water and solute, is a kind of mode of environment in regulation, is contemporary severe
The impressive progress of medical science, has evolved into the Important Platform and means of organ support.Removing moisture and solute unnecessary in vivo
While, it is necessary to reasonable supplement beneficial solute and water.In blood purification, the water removed for supplement and the solute lost can
According to plasma fraction, the liquid of the water and solute that are used to replace removing of configuration is referred to as displacement liquid, is needed when configuring displacement liquid
Note the pH value and various electrolyte concentrations of displacement liquid.
In blood purification, closest displacement liquid is clinical optimal selection with plasma fraction.Carbonate displacement liquid is
The displacement liquid configured by base of carbonic acid, it is most like with human plasma composition, but due to carbonic acid base can with the calcium in displacement liquid,
Magnesium ion forms water insoluble precipitation, not only changes displacement liquid composition, and small precipitation can be deposited to microcirculation, making patients
The state of an illness.In addition, carbonate decomposable asymmetric choice net generate carbon dioxide, cause displacement liquid unstable, it is impossible to industrialized production, clinically for gram
Take drawbacks described above, more using now with the current or be respectively connected to using Y type interfaces, it is now with the current at least need more than half an hour when
Between, clinical preparation is dramatically increased to the time really implemented, and is unfavorable for operation for the critical patient that time is life
Implement as early as possible.
The displacement liquid of energy industrialized production is generally lactate displacement liquid or Chinese holly edge hydrochlorate displacement liquid, although both displacement liquids
Performance is stable, can preserve for a long time, but both are both needed to the metabolism in liver and are converted to carbonate, have aggravated burden of liver.
The content of the invention
The present invention seeks to solve the above problems there is provided a kind of determination for overcoming carbonate displacement liquid unstable, simultaneously
Displacement liquid industrialized production is may be such that, the operating efficiency of blood purification is improved, simplifies blood purification implementing procedure, reduces and matches somebody with somebody liquid mistake
Displacement liquid flow matches device and flow matches method in the continuous blood purification of pollution that may be present in journey.
To reach above-mentioned purpose, the technical solution adopted by the present invention is：Flow quantity is replaced in a kind of continuous blood purification
Coalignment, including liquid mixer and at least 2 groups dripping and leaking devices, each dripping and leaking device include woven hose, dropper, whirlpool
Wheel, axle and gear, wherein,
The upper end of the woven hose is provided with contact pin, and lower end connects with the upper end of dropper；
The turbine and gear are respectively arranged on the upper and lower end of axle, and the turbine is in dropper, in its outer cylinder and dropper
Wall inscribe；
The gear external toothing of two adjacent dripping and leaking devices；
The lower end of each dripping and leaking device is communicated with liquid mixer.
Wherein, in the upper end insertion displacement liquid of the contact pin, the proportioning and two water clocks of the displacement liquid of two dripping and leaking devices are flowed through
The gear ratio of device is equal.
Further, the contact pin is provided with several side openings.
Wherein, the woven hose is provided with thumbwheel switch.
Wherein, the lower woven hose for conveying displacement liquid to patient, the lower transfusion are connected with the liquid mixer
Shrink-ring is provided with the inside of the oral area of pipe, outboard cover is provided with head protector.
The present invention also provides a kind of flow using displacement liquid flow matches device in above-mentioned continuous blood purification
Method of completing the square, includes preparation, the assembling of displacement liquid flow matches device, the preparation of displacement liquid of displacement liquid flow matches device, its
In,
1st, the preparation of displacement liquid flow matches device comprises the following steps：
（1-1）By 100 parts by weight high polymer materials, 0.1~3 parts by weight of inorganic antiseptic, 0.5~3 parts by weight slow releasing medicinal
Thing, 30~50 parts by weight of plasticizer, 3~10 parts by weight lubricating modification agent, 2~6 parts by weight stabilizers and the punching of 10~30 parts by weight
Hit modifying agent to mix in proportion, composite is made；
（1-2）Composite is placed in plastic extruder, is extruded at a temperature of 150~180 DEG C and uses pelleter pelletizing,
Obtain medical antibacterial plastic grain；
（1-3）By step（1-2）Gained medical antibacterial plastic grain is placed in extruder, is extruded by extruding cooling method
Several carry the dropper of woven hose；
（1-4）By step（1-2）Gained medical antibacterial plastic grain is placed in injection machine, at a temperature of 180~260 DEG C
Several turbines of injection molding and axle；
（1-5）By step（1-2）Gained medical antibacterial plastic grain is placed in injection machine, at a temperature of 210~260 DEG C
The gear of injection molding several sizes, the number of teeth not etc.；
（1-6）By step（1-2）Gained medical antibacterial plastic grain is placed in extruder, is extruded by extruding cooling method
Liquid mixer, and the mounting hole being connected with dropper is opened up in the upper end of liquid mixer, lower end offers displacement liquid outlet；
2nd, the assembling of displacement liquid flow matches device comprises the following steps：
（2-1）Turbine and gear are installed on to the upper and lower side of axle respectively；
（2-2）Turbine is inserted in dropper, it is ensured that turbine outer cylinder and dropper inwall inscribe；
（2-3）Contact pin is installed in woven hose upper end, thumbwheel switch is installed at least one woven hose；
（2-4）Repeat step（2-1）~（2-3）, prepare multigroup dripping and leaking device；
（2-5）According to the species of stoste needed for configuration displacement liquid, the dripping and leaking device of respective amount is passed through into mounting hole and liquid
Body blender is fixedly connected, and ensures the gear external toothing of connected dripping and leaking device after connection；
（2-6）The woven hose under the displacement liquid exit connection of liquid mixer lower end, for conveying displacement liquid to patient；
3rd, the preparation of displacement liquid comprises the following steps：
（3-1）At least prepare two kinds of each portions of replacing base liquid；
（3-2）The contact pin correspondence of dripping and leaking device is inserted in replacing base liquid, the wherein few gear mesh of the number of teeth answers aequum
Larger replacing base liquid；
（3-3）The drop speed of displacement liquid according to required by sufferer situation opens the thumbwheel switch of two dripping and leaking devices, wherein one
When kind replacing base liquid flows through turbine, cause turbine rotation, drive and the gear of turbine linkage is rotated at the same speed, this kind of replacing base
Liquid mixer is advanced under liquid；Another gear engaged with the gear is transmitted according to gearratio, and it is another that drive links therewith
One turbine rotation so that another replacing base liquid is descending, multigroup dripping and leaking device is similarly run, and the flow of a variety of replacing base liquids is obtained
Obtain and accurately match, and mixed in liquid mixer, form displacement liquid.
Wherein, the replacing base liquid is respectively blood purification replacing base liquid, the alkalies configured with reference to plasma fraction
Body.
It is preferred that, the blood purification replacing base liquid includes sodium, potassium, calcium, magnesium, chlorine, sugar, and the akaline liquid is 5% Soviet Union
Fetch water.
Because above-mentioned technical proposal is used, the present invention has following advantages compared with prior art：
1st, the displacement liquid flow matches device that the present invention is provided can realize real-time blood purification replacing base liquid and clinic
The most commonly used akaline liquid（5% soda water）Extracted and mixed in proportion, purpose just is prepared so as to reach, can be with
The batch production that is standardized is prepared, and reduces cost, and be avoided that the pollution of clinical configuration process, metering it is inaccurate, very
The problems such as to mistake, it is ensured that the inherent quality of displacement liquid, and it is easy to long-term storage and transport, be conducive to quickly carrying out blood
Purification treatment, shortens the rescue time of critical patient.
2nd, the displacement liquid prepared using the displacement liquid flow matches device and flow matches method of the present invention is not required in liver
Middle metabolic conversion is carbonate, and the problem of aggravate burden of liver；Also be not in carbonic acid base and the calcium in displacement liquid, magnesium shape
Into precipitation, situations such as carbonate decomposition forms carbon dioxide, displacement liquid is stable, can industrialized production.
Brief description of the drawings
Fig. 1 is the structure diagram of the embodiment of the present invention one.
Description of reference numerals：
1st, liquid mixer；
2nd, woven hose；
3rd, dropper；
4th, turbine；
5th, axle；
6th, gear；
7th, contact pin；70th, side opening.
Embodiment
Below in conjunction with the accompanying drawings and embodiment the invention will be further described：
Embodiment one：Shown in Fig. 1, displacement liquid flow matches device in a kind of continuous blood purification, including liquid mixing
Device 1 and at least 2 groups dripping and leaking devices, each dripping and leaking device include woven hose 2, dropper 3, turbine 4, axle 5 and gear 6, wherein,
The upper end of the woven hose 2 is provided with contact pin 7, and lower end connects with the upper end of dropper 3；
The turbine 4 and gear 6 are respectively arranged on the upper and lower end of axle 5, the turbine 4 in dropper 3, its outer cylinder with
Dropper inwall inscribe；
The external toothing of gear 6 of two adjacent dripping and leaking devices；
The lower end of each dripping and leaking device is communicated with liquid mixer 1.
In the upper end insertion displacement liquid of the contact pin 7, the proportioning and two dripping and leaking devices of the displacement liquid of two dripping and leaking devices are flowed through
Gear ratio it is equal.
The contact pin 7 is provided with several side openings 70.
The woven hose 2 is provided with thumbwheel switch.
The lower woven hose for conveying displacement liquid to patient is connected with the liquid mixer 1, the lower woven hose
Shrink-ring is provided with the inside of oral area, outboard cover is provided with head protector.
The embodiment of the present invention one also provides displacement liquid flow matches device in a kind of above-mentioned continuous blood purification of utilization
Flow matches method, including the preparation of displacement liquid flow matches device, the assembling of displacement liquid flow matches device, displacement liquid
Prepare, wherein,
1st, the preparation of displacement liquid flow matches device comprises the following steps：
（1-1）By 100 parts by weight high polymer materials, 0.1~3 parts by weight of inorganic antiseptic, 0.5~3 parts by weight slow releasing medicinal
Thing, 30~50 parts by weight of plasticizer, 3~10 parts by weight lubricating modification agent, 2~6 parts by weight stabilizers and the punching of 10~30 parts by weight
Hit modifying agent to mix in proportion, composite is made；
（1-2）Composite is placed in plastic extruder, is extruded at a temperature of 150~180 DEG C and uses pelleter pelletizing,
Obtain medical antibacterial plastic grain；
（1-3）By step（1-2）Gained medical antibacterial plastic grain is placed in extruder, is extruded by extruding cooling method
Several carry the dropper of woven hose；
（1-4）By step（1-2）Gained medical antibacterial plastic grain is placed in injection machine, at a temperature of 180~260 DEG C
Several turbines of injection molding and axle；
（1-5）By step（1-2）Gained medical antibacterial plastic grain is placed in injection machine, at a temperature of 210~260 DEG C
The gear of injection molding several sizes, the number of teeth not etc.；
（1-6）By step（1-2）Gained medical antibacterial plastic grain is placed in extruder, is extruded by extruding cooling method
Liquid mixer, and the mounting hole being connected with dropper is opened up in the upper end of liquid mixer, lower end offers displacement liquid outlet, liquid
The wherein side wall of body blender can be opened, for gear to be put into.
2nd, the assembling of displacement liquid flow matches device comprises the following steps：
（2-1）Turbine and gear are installed on to the upper and lower side of axle respectively；
Note：The gear of the different numbers of teeth according to the difference of replacing base liquid hold-up in displacement liquid, can be changed, blood is not limited to
Purification, the liquid proportion available for any occasion；
（2-2）Turbine is inserted in dropper, it is ensured that turbine outer cylinder and dropper inwall inscribe and position in the axial direction；
（2-3）Contact pin is installed in woven hose upper end, thumbwheel switch is installed at least one woven hose；
（2-4）Repeat step（2-1）~（2-3）, prepare multigroup dripping and leaking device；
（2-5）According to the species of stoste needed for configuration displacement liquid, the dripping and leaking device of respective amount is passed through into mounting hole and liquid
Body blender is fixedly connected, and ensures the gear external toothing of connected dripping and leaking device after connection；
（2-6）The woven hose under the displacement liquid exit connection of liquid mixer lower end, for conveying displacement liquid to patient.
3rd, the preparation of displacement liquid comprises the following steps：
（3-1）At least prepare two kinds of each portions of replacing base liquid；
（3-2）The contact pin correspondence of dripping and leaking device is inserted in replacing base liquid, the wherein few gear mesh of the number of teeth answers aequum
Larger replacing base liquid；
（3-3）The drop speed of displacement liquid according to required by sufferer situation opens the thumbwheel switch of two dripping and leaking devices, wherein one
When kind replacing base liquid flows through turbine, cause turbine rotation, drive and the gear of turbine linkage is rotated at the same speed, this kind of replacing base
Liquid mixer is advanced under liquid；Another gear engaged with the gear is transmitted according to gearratio, and it is another that drive links therewith
One turbine rotation so that another replacing base liquid is descending, multigroup dripping and leaking device is similarly run, and the flow of a variety of replacing base liquids is obtained
Obtain and accurately match, and mixed in liquid mixer, form displacement liquid.
In the present embodiment, displacement liquid flow matches device is provided with 2 groups of dripping and leaking devices, for the mixing of replacing base liquid in 2,
2 kinds of replacing base liquids are respectively blood purification replacing base liquid, 5% soda water configured with reference to plasma fraction（Na2CO3）.
Wherein, the blood purification replacing base liquid includes sodium, potassium, calcium, magnesium, chlorine, sugar, and the akaline liquid is.
The displacement liquid flow matches device that the present invention is provided can realize real-time blood purification replacing base liquid and clinic most
For conventional akaline liquid（5% soda water）Extracted and mixed in proportion, purpose just, Ke Yijin are prepared so as to reach
The batch production of professional etiquette generalized is prepared, and reduces cost, and be avoided that the pollution of clinical configuration process, metering it is inaccurate, even
The problems such as mistake, it is ensured that the inherent quality of displacement liquid, and be easy to long-term storage and transport, be conducive to quickly carrying out blood net
Change treatment, shorten the rescue time of critical patient.
The displacement liquid prepared using the displacement liquid flow matches device and flow matches method of the present invention is not required in liver
Metabolic conversion is carbonate, and the problem of aggravate burden of liver；Also be not in that carbonic acid base is formed with the calcium in displacement liquid, magnesium
Situations such as precipitation, carbonate decomposition formation carbon dioxide, displacement liquid is stable, can industrialized production.
Described above is the preferred embodiment of the present invention, it is noted that for those skilled in the art
For, on the premise of principle of the present invention is not departed from, some improvement or replacement can also be made, these improve or replaced
It should be regarded as protection scope of the present invention.
Claims (6)
1. displacement liquid flow matches device in a kind of continuous blood purification, it is characterised in that including liquid mixer and at least 2
Group dripping and leaking device, each dripping and leaking device includes woven hose, dropper, turbine, axle and gear, wherein,
The upper end of the woven hose is provided with contact pin, and lower end connects with the upper end of dropper；
The turbine and gear are respectively arranged on the upper and lower end of axle, and the turbine is in dropper, in its outer cylinder and dropper inwall
Cut；
The gear external toothing of two adjacent dripping and leaking devices；
The lower end of each dripping and leaking device is communicated with liquid mixer；
The woven hose is provided with thumbwheel switch；
In the upper end insertion displacement liquid of the contact pin, the proportioning and the gear of two dripping and leaking devices of the displacement liquid of two dripping and leaking devices are flowed through
Gearratio is equal.
2. displacement liquid flow matches device in continuous blood purification according to claim 1, it is characterised in that described to insert
Pin is provided with several side openings.
3. displacement liquid flow matches device in continuous blood purification according to claim 1, it is characterised in that the liquid
It is connected with body blender on the inside of the lower woven hose for conveying displacement liquid to patient, the oral area of the lower woven hose provided with deflation
Ring, outboard cover is provided with head protector.
4. one kind is using such as displacement liquid flow matches device in continuous blood purification according to any one of claims 1 to 3
Flow matches method, it is characterised in that the preparation including displacement liquid flow matches device, the group of displacement liquid flow matches device
Dress, the preparation of displacement liquid, wherein,
1st, the preparation of displacement liquid flow matches device comprises the following steps：
（1-1）By 100 parts by weight high polymer materials, 0.1~3 parts by weight of inorganic antiseptic, 0.5~3 parts by weight slow releasing pharmaceutical,
30~50 parts by weight of plasticizer, 3~10 parts by weight lubricating modification agent, 2~6 parts by weight stabilizers and the impact of 10~30 parts by weight change
Property agent is mixed in proportion, and composite is made；
（1-2）Composite is placed in plastic extruder, is extruded at a temperature of 150~180 DEG C and uses pelleter pelletizing, obtained
Medical antibacterial plastic grain；
（1-3）By step（1-2）Gained medical antibacterial plastic grain is placed in extruder, some by extruding cooling method extrusion
The individual dropper with woven hose；
（1-4）By step（1-2）Gained medical antibacterial plastic grain is placed in injection machine, at a temperature of 180~260 DEG C
Several turbines of injection molding and axle；
（1-5）By step（1-2）Gained medical antibacterial plastic grain is placed in injection machine, at a temperature of 210~260 DEG C
The gear of injection molding several sizes, the number of teeth not etc.；
（1-6）By step（1-2）Gained medical antibacterial plastic grain is placed in extruder, and liquid is extruded by extruding cooling method
Blender, and the mounting hole being connected with dropper is opened up in the upper end of liquid mixer, lower end offers displacement liquid outlet；
2nd, the assembling of displacement liquid flow matches device comprises the following steps：
（2-1）Turbine and gear are installed on to the upper and lower side of axle respectively；
（2-2）Turbine is inserted in dropper, it is ensured that turbine outer cylinder and dropper inwall inscribe；
（2-3）Contact pin is installed in woven hose upper end, thumbwheel switch is installed at least one woven hose；
（2-4）Repeat step（2-1）~（2-3）, prepare multigroup dripping and leaking device；
（2-5）According to the species of stoste needed for configuration displacement liquid, the dripping and leaking device of respective amount is mixed by mounting hole with liquid
Clutch is fixedly connected, and ensures the gear external toothing of connected dripping and leaking device after connection；
（2-6）The woven hose under the displacement liquid exit connection of liquid mixer lower end, for conveying displacement liquid to patient；
3rd, the preparation of displacement liquid comprises the following steps：
（3-1）At least prepare two kinds of each portions of replacing base liquid；
（3-2）The contact pin correspondence of dripping and leaking device is inserted in replacing base liquid, the wherein few gear mesh of the number of teeth answers aequum larger
Replacing base liquid；
（3-3）The drop speed of displacement liquid according to required by sufferer situation opens the thumbwheel switch of two dripping and leaking devices, and one of which is put
When changing basal liquid and flowing through turbine, cause turbine rotation, drive the gear with turbine linkage to rotate at the same speed, under this kind of replacing base liquid
It is advanced into liquid mixer；Another gear engaged with the gear is transmitted according to gearratio, drives another whirlpool linked therewith
Wheel is rotated so that another replacing base liquid is descending, and multigroup dripping and leaking device is similarly run, and the flow of a variety of replacing base liquids obtains essence
Really proportioning, and being mixed in liquid mixer, forms displacement liquid.
5. flow matches method according to claim 4, it is characterised in that the replacing base liquid is respectively with reference to blood plasma
Blood purification replacing base liquid, the akaline liquid of composition configuration.
6. flow matches method according to claim 5, it is characterised in that the blood purification replacing base liquid is included
Sodium, potassium, calcium, magnesium, chlorine, sugar, the akaline liquid are 5% soda water.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510405293.6A CN104906647B (en) | 2015-07-13 | 2015-07-13 | Displacement liquid flow matches device and flow matches method in continuous blood purification |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510405293.6A CN104906647B (en) | 2015-07-13 | 2015-07-13 | Displacement liquid flow matches device and flow matches method in continuous blood purification |
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| Publication Number | Publication Date |
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| CN104906647A CN104906647A (en) | 2015-09-16 |
| CN104906647B true CN104906647B (en) | 2017-10-17 |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995007066A1 (en) * | 1993-09-07 | 1995-03-16 | Debiotech S.A. | Syringe device for mixing two compounds |
| CN1193919A (en) * | 1995-08-25 | 1998-09-23 | 生物技术公司 | Continuously operating infusion device and method |
| CN102284102A (en) * | 2011-07-25 | 2011-12-21 | 广东工业大学 | Disposable closed deflating blood transfusion device |
| CN103402619A (en) * | 2010-12-24 | 2013-11-20 | 厄弗翁简易股份公司 | Device for mixing at least two constituents |
| CN204840432U (en) * | 2015-07-13 | 2015-12-09 | 南通市第三人民医院 | Replacement liquid stream volume matching unit during continuity blood purifies |
-
2015
- 2015-07-13 CN CN201510405293.6A patent/CN104906647B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995007066A1 (en) * | 1993-09-07 | 1995-03-16 | Debiotech S.A. | Syringe device for mixing two compounds |
| CN1193919A (en) * | 1995-08-25 | 1998-09-23 | 生物技术公司 | Continuously operating infusion device and method |
| CN103402619A (en) * | 2010-12-24 | 2013-11-20 | 厄弗翁简易股份公司 | Device for mixing at least two constituents |
| CN102284102A (en) * | 2011-07-25 | 2011-12-21 | 广东工业大学 | Disposable closed deflating blood transfusion device |
| CN204840432U (en) * | 2015-07-13 | 2015-12-09 | 南通市第三人民医院 | Replacement liquid stream volume matching unit during continuity blood purifies |
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| Publication number | Publication date |
|---|---|
| CN104906647A (en) | 2015-09-16 |
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