CN104906384A - Preparation method for active dendrobium candidum superfine powder - Google Patents
Preparation method for active dendrobium candidum superfine powder Download PDFInfo
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- CN104906384A CN104906384A CN201510242263.8A CN201510242263A CN104906384A CN 104906384 A CN104906384 A CN 104906384A CN 201510242263 A CN201510242263 A CN 201510242263A CN 104906384 A CN104906384 A CN 104906384A
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Abstract
The invention discloses a preparation method for active dendrobium candidum superfine powder. The preparation method comprises steps: first, leaves of harvested fresh dendrobium candidum are removed, and washing and draining are carried out; second, punching is carried out, the dendrobium officinale is fixed on a die, the die is placed on a shelf of a vacuum drying container, cooling is carried out, the die is a cube-shaped metal die body (1) with an upper surface equipped with a half-cylindrical groove (2), and small holes (3) are arranged in the die body; third, vacuum-pumping is carried out; fourth, the shelf is heated, the temperature is risen to 0 DEG C, the pressure intensity is kept at 20-100Pa, drying is carried out, the material temperature is risen from 0 DEG C to 20 DEG C, the pressure intensity is kept at 10-20Pa, drying is carried out, the material temperature is risen from 20 DEG C to 40 DEG C, the pressure intensity is kept within 10Pa, drying is carried out, pressurization to a normal pressure is carried out; fifth, low temperature air-flow crushing is carried out, and active dendrobium candidum superfine powder is obtained and more than 95% of active dendrobium candidum superfine powder has a particle size of being less than 20 micrometers. The freeze-drying rate is high, freeze-drying time is saved, energy consumption is lowered, the product has a small particle size and is easy to dissolve and absorb, and the bioavailability is high.
Description
Technical field
The present invention relates to a kind of method of lyophilization Herba Dendrobii, particularly relate to a kind of preparation method of active dendrobium candidum ultrafine powder.
Background technology
Herba Dendrobii is the dry stem of the orchid family Dendrobium Sw Herba Dendrobii (Dendrobiumofficinale Kimura et Migo), gains the name because epidermis is ferrum green.Dendrobium Sw can be divided into the dozens of kind such as iron sheet, Dendrobium nobile Lindl, Huoshan, Dendrobium denneanum Kerr., Herba Dendrobii, horsewhip by form, the place of production etc., wherein precious with Herba Dendrobii.Dendrobium officinale is born on the dark and damp rock in mountain region half between height above sea level 100 ~ 3000m, bark, and happiness warm and moist weather and half dark and damp environment, do not resist cold.The fresh stem of Herba Dendrobii is direct-edible, or stews, or makes tea, or infusing drugs in wine, is usually processed into dry product, as Herba Dendrobii etc.Herba Dendrobii has good medical value and health value, people are increasing to its demand, but the iron-sheet dendrobe fresh product holding time is shorter, and though routine can extend the holding time after drying, but organoleptic indicator is deteriorated, the particularly important is, effective physiologically active ingredient is also influenced, causes its effect to decline.Therefore a lot of people has carried out large quantifier elimination to Herba Dendrobii deep process.
Chinese Patent Application No. 201110274978.3 discloses a kind of processing method capable of reserving all components of dendrobium officinale, the method is by fresh Herba Dendrobii removing fibrous root and impurity, clean, wipe thin film on epidermis away, cut into 3cm segment, take 1000g, to put in instant freezer pre-freeze 4 hours, temperature is down to-80 DEG C, it is made all to freeze, condenser temperature is dropped to-40 DEG C, starts evacuation, when vacuum is down to 25Pa, make Herba Dendrobii in sublimation process temperature lower than-40 DEG C, sublimation drying 38 hours, when Vacuum Pressure is down to 10Pa, sublimation drying process terminates; Continue plate temperature to be set to 25 DEG C, evacuation, resolve 12 hours.This patent pre-freeze 4 hours, sublimation drying 38 hours, parsing-desiccation 12 hours, whole process need 54 hours, sublimation process temperature is lower than-40 DEG C, and whole sublimation process is too many lower than eutectic temperature, causes that freeze-drying time is long, energy consumption is large, lyophilizing efficiency is low.
Chinese Patent Application No. 201410426017.3, disclose Herba Dendrobii lyophilized powder and preparation method thereof, Chinese Patent Application No. 201210569059.3 discloses a kind of dendrobe ultrafine powder preparation technology, be all that after Herba Dendrobii adds a certain proportion of water, grinding is pulled an oar, then their mixed solution lyophilization is become goods.Owing to needing to add a certain proportion of water in technique, cause virtually adding unit energy consumption of freeze drying and lyophilizing efficiency.
In addition, also have plenty of and dendrobium officinale powder or section are carried out high-temperature process oven dry, these methods can cause the destruction of active component, effective ingredient, mouthfeel, color and luster, outward appearance etc. all can change, grinding time is relatively long again, during pulverizing, partial material is heated higher, and the superfine powder rehydration after processing is poor.
Summary of the invention
The running cost that the object of the invention is to overcome prior art existence is higher, and the shortcomings such as the production cycle is long, and energy consumption is large, provide a kind of preparation method of active dendrobium candidum ultrafine powder.
Technical scheme of the present invention is summarized as follows:
A preparation method for active dendrobium candidum ultrafine powder, comprises the steps:
1) by fresh Herba Dendrobii removing blade of gathering, clean, drain;
2) Herba Dendrobii punching step (1) obtained, be fixed on mould by the Herba Dendrobii after punching, be placed on the shelf of dry vacuum container, material is cooled to-35 DEG C ~-40 DEG C, maintains 1-3 hour; Described mould is the metal die body (1) that upper surface is provided with the cubic of semicolumn groove (2), and die ontology is provided with aperture (3);
3) being evacuated to pressure is 20 ~ 100Pa, maintains 1 ~ 3 hour;
4) heat the shelf in dry vacuum container, make material rise to 0 DEG C from-35 DEG C ~-40 DEG C, pressure remains on 20 ~ 100Pa, sublimation drying 10 ~ 20 hours; Material rises to 20 DEG C from 0 DEG C, and pressure remains on 10 ~ 20Pa, parsing-desiccation 1 ~ 3 hour, and material rises to 40 DEG C, within pressure remains on 10Pa from 20 DEG C, parsing-desiccation 1 ~ 3 hour; After being forced into normal pressure, deliver from godown, obtain the Herba Dendrobii that biodiversity content is 3% ~ 6%;
5) by the Herba Dendrobii that step (4) obtains, under 2 ~ 20 DEG C of conditions, carry out comminution by gas stream 2 ~ 10min, the particle diameter obtaining more than 95% is the active dendrobium candidum ultrafine powder of less than 20 μm.
Step 1) be preferably: by fresh Herba Dendrobii removing blade of gathering, clean, drain, be cut into the section of 1 ~ 10cm.
Advantage of the present invention:
Herba Dendrobii punches by the present invention, is fixed on mould after punching, and the moisture passing hole rapid sublimation of Herba Dendrobii inside is overflowed.In view of Herba Dendrobii is cylindrical elongate, the feature such as bending, little with dry vacuum container shelf contact area, the pre-freeze time (step of the present invention (2)) postpones long, thorough, and in lyophilization process, heat-transfer effect is poor.Adopt the mould in the inventive method, add pre-freeze and heat-transfer effect, accelerate lyophilizing efficiency, thus reach the object of rapid freeze-drying, and Herba Dendrobii outward appearance after lyophilizing is straight, color and luster does not destroy, mouthfeel crispy savoury.
Method of the present invention directly makes active dendrobium candidum ultrafine powder by carrying out low-temperature airflow pulverizing after fresh Herba Dendrobii lyophilizing, its color and luster, quality and fresh goods are substantially identical, product rehydration is fabulous, can be absorbed water rapidly recovery, at utmost can retain the active component in Herba Dendrobii, give full play to the drug effect of Herba Dendrobii, and shortened the production cycle of whole lyophilizing, energy consumption of freeze drying and cost reduce.
The present invention adopts pressure stage reduction technology, reach the balance that hothouse pressure affects heat transfer in vacuum lyophilization process and mass transfer, achieve heat and mass transfer process better, make the steam of overflowing from material in time by cold trap trapping, reduce the freeze-drying time required for it widely, thus reach the object of rapid freeze-drying.
The low-temperature airflow crushing technology that the present invention adopts, controls pulverizings temperature at 20 DEG C and following, thus the effective ingredient that Herba Dendrobii can be avoided to occur in crushing process oxidation, volatile oil and other heat-sensitive substances be destroyed etc., and quality deterioration reacts.Herba Dendrobii through vacuum lyophilization is pulverized through low temperature ultrahigh speed gas flow crushing process again, and it is less than 20 μm that its fineness can reach the particle diameter obtaining more than 95%, the fineness of the particles of traditional dendrobium officinale powder is improve 10-20 doubly.Because the fineness of the particles of Herba Dendrobii powder reaches 10-15 μm, directly human body mucosa absorption can be passed through, granule surface area increases, make active ingredient very easily in dissolving and absorption, its bioavailability significantly improves, Herba Dendrobii degree of absorption reaches the degree of the clean extract of Herba Dendrobii, and physiologically active is strengthened.Meanwhile, due to dendrobium candidum ultrafine powder employing is physical method, objectively remains the activity of Herba Dendrobii completely, makes the various effective ingredient of Herba Dendrobii obtain complete reservation, not by any destruction.Reach the effects such as consumption is few, instant effect.Be better than the dry Herba Dendrobii powder body of common conventional heat (only having tens orders).
Method of the present invention effectively can remain with effective component content, ensures good dried frozen aquatic products face shaping; Meanwhile, under the prerequisite meeting outward appearance and product quality, freeze drying rate of the present invention is high, effectively saves freeze-drying time, reduces energy consumption of freeze drying, is conducive to the saving of production cost.
Goods after lyophilizing of the present invention adopt vacuum or nitrogen gas packing and keep in Dark Place, long shelf-life.More be conducive to the stability of Herba Dendrobii in storage process.
When the active dendrobium candidum ultrafine powder method routinely made by method of the present invention is prepared into capsule or sheet or buccal tablet, there is the features such as active high, content is high, consumption is few, easy absorption, improve its economy and use value.
Accompanying drawing explanation
Fig. 1 is the structural representation of mould.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention is further illustrated.
Embodiment 1
A preparation method for active dendrobium candidum ultrafine powder, is characterized in that comprising the steps:
1) by fresh Herba Dendrobii removing blade of gathering, clean, drain;
2) Herba Dendrobii punching step (1) obtained, be fixed on mould by the Herba Dendrobii after punching, be placed in dry vacuum container, material is cooled to-35 DEG C ~-40 DEG C, maintains 2 hours; Described mould is the metal die body (1) that upper surface is provided with the cubic of semicolumn groove (2), and die ontology is provided with aperture (3); Metal is rustless steel.
3) being evacuated to pressure is 20 ~ 100Pa, maintains 2 hours;
4) heat the shelf in dry vacuum container, make material rise to 0 DEG C from-35 DEG C ~-40 DEG C, pressure remains on 20 ~ 100Pa, sublimation drying 15 hours; Material rises to 20 DEG C from 0 DEG C, and pressure remains on 10 ~ 20Pa, parsing-desiccation 2 hours, and material rises to 40 DEG C, within pressure remains on 10Pa from 20 DEG C, parsing-desiccation 2 hours; After being forced into normal pressure, deliver from godown, obtain the Herba Dendrobii that biodiversity content is 3% ~ 6%;
5) by the Herba Dendrobii that step (4) obtains, under 10 DEG C of conditions, carry out comminution by gas stream 5min, the particle diameter obtaining more than 95% is the active dendrobium candidum ultrafine powder of less than 20 μm.
6) pack: loaded by active dendrobium candidum ultrafine powder in clean packaging, airtight vacuum is packed.
Embodiment 2
A preparation method for active dendrobium candidum ultrafine powder, is characterized in that comprising the steps:
1) by fresh Herba Dendrobii removing blade of gathering, clean, drain, be cut into the section of 10cm;
2) Herba Dendrobii punching step (1) obtained, be fixed on mould by the Herba Dendrobii after punching, be placed in dry vacuum container, material is cooled to-35 DEG C ~-40 DEG C, maintains 3 hours; Described mould is the metal die body (1) that upper surface is provided with the cubic of semicolumn groove (2), and die ontology is provided with aperture (3); Metal is copper.
3) being evacuated to pressure is 20 ~ 100Pa, maintains 3 hours;
4) heat the shelf in dry vacuum container, make material rise to 0 DEG C from-35 DEG C ~-40 DEG C, pressure remains on 20 ~ 100Pa, sublimation drying 10 hours; Material rises to 20 DEG C from 0 DEG C, and pressure remains on 10 ~ 20Pa, parsing-desiccation 3 hours, and material rises to 40 DEG C of pressure from 20 DEG C, within remaining on 10Pa, and parsing-desiccation 3 hours; After being forced into normal pressure, deliver from godown, obtain the Herba Dendrobii that biodiversity content is 3% ~ 6%;
5) by the Herba Dendrobii that step (4) obtains, under 2 DEG C of conditions, carry out comminution by gas stream 10min, the particle diameter obtaining more than 95% is the active dendrobium candidum ultrafine powder of less than 20 μm.
6) pack: active dendrobium candidum ultrafine powder is loaded in clean packaging, rush nitrogen packaging.
Embodiment 3
A preparation method for active dendrobium candidum ultrafine powder, is characterized in that comprising the steps:
1) by fresh Herba Dendrobii removing blade of gathering, clean, drain, be cut into the section of 1cm;
2) Herba Dendrobii punching step (1) obtained, be fixed on mould by the Herba Dendrobii after punching, be placed in dry vacuum container, material is cooled to-35 DEG C ~-40 DEG C, maintains 1 hour; Described mould is the metal die body (1) that upper surface is provided with the cubic of semicolumn groove (2), and die ontology is provided with aperture (3); Metal is rustless steel;
3) being evacuated to pressure is 20 ~ 100Pa, maintains 1 hour;
4) heat the shelf in dry vacuum container, make material rise to 0 DEG C from-35 DEG C ~-40 DEG C, pressure remains on 20 ~ 100Pa, sublimation drying 20 hours; Material rises to 20 DEG C from 0 DEG C, and pressure remains on 10 ~ 20Pa, parsing-desiccation 1 hour, and material rises to 40 DEG C of pressure from 20 DEG C, within remaining on 10Pa, and parsing-desiccation 1 hour; After being forced into normal pressure, deliver from godown, obtain the Herba Dendrobii that biodiversity content is 3% ~ 6%;
5) by the Herba Dendrobii that step (4) obtains, under 20 DEG C of conditions, carry out comminution by gas stream 2min, the particle diameter obtaining more than 95% is the active dendrobium candidum ultrafine powder of less than 20 μm.
6) pack: active dendrobium candidum ultrafine powder is loaded in clean packaging, rush nitrogen packaging.
Claims (2)
1. a preparation method for active dendrobium candidum ultrafine powder, is characterized in that comprising the steps:
1) by fresh Herba Dendrobii removing blade of gathering, clean, drain;
2) Herba Dendrobii punching step (1) obtained, be fixed on mould by the Herba Dendrobii after punching, be placed on the shelf of dry vacuum container, material is cooled to-35 DEG C ~-40 DEG C, maintains 1-3 hour; Described mould is the metal die body (1) that upper surface is provided with the cubic of semicolumn groove (2), and die ontology is provided with aperture (3);
3) being evacuated to pressure is 20 ~ 100Pa, maintains 1 ~ 3 hour;
4) heat the shelf in dry vacuum container, make material rise to 0 DEG C from-35 DEG C ~-40 DEG C, pressure remains on 20 ~ 100Pa, sublimation drying 10 ~ 20 hours; Material rises to 20 DEG C from 0 DEG C, and pressure remains on 10 ~ 20Pa, parsing-desiccation 1 ~ 3 hour, and material rises to 40 DEG C, within pressure remains on 10Pa from 20 DEG C, parsing-desiccation 1 ~ 3 hour; After being forced into normal pressure, deliver from godown, obtain the Herba Dendrobii that biodiversity content is 3% ~ 6%;
5) by the Herba Dendrobii that step (4) obtains, under 2 ~ 20 DEG C of conditions, carry out comminution by gas stream 2 ~ 10min, the particle diameter obtaining more than 95% is the active dendrobium candidum ultrafine powder of less than 20 μm.
2. the preparation method of a kind of active dendrobium candidum ultrafine powder according to claim 1, is characterized in that described step 1) be: by fresh Herba Dendrobii removing blade of gathering, clean, drain, be cut into the section of 1 ~ 10cm.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105748944A (en) * | 2016-05-05 | 2016-07-13 | 上海雷允上药业有限公司神象参茸分公司 | Preparation method of dendrobium officinale decoction pieces |
| CN106072516A (en) * | 2016-06-08 | 2016-11-09 | 李莉萍 | A kind of preparation method of Herba Dendrobii freeze-dried instant powder |
| CN109123623A (en) * | 2018-08-14 | 2019-01-04 | 福建新味食品有限公司 | A kind of processing method and application of dendrobium candidum |
| CN109223985A (en) * | 2018-11-06 | 2019-01-18 | 胡爱娣 | A kind of dendrobium candidum American Ginseng Ultramicro-powder microwave vacuum freeze drying means |
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| CN102302680A (en) * | 2011-09-16 | 2012-01-04 | 蔡光先 | Processing method capable of reserving all components of dendrobium officinale |
| CN102319364A (en) * | 2011-09-22 | 2012-01-18 | 澄思源生物科技（上海）有限公司 | Manufacturing method of dendrobium candidum wallex lindll pure powder tablets |
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2015
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Patent Citations (3)
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| CN102178848A (en) * | 2011-05-04 | 2011-09-14 | 湖南龙石山铁皮石斛基地有限公司 | Traditional Chinese medicinal dendrobium officinale preparation and preparation method thereof |
| CN102302680A (en) * | 2011-09-16 | 2012-01-04 | 蔡光先 | Processing method capable of reserving all components of dendrobium officinale |
| CN102319364A (en) * | 2011-09-22 | 2012-01-18 | 澄思源生物科技（上海）有限公司 | Manufacturing method of dendrobium candidum wallex lindll pure powder tablets |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105748944A (en) * | 2016-05-05 | 2016-07-13 | 上海雷允上药业有限公司神象参茸分公司 | Preparation method of dendrobium officinale decoction pieces |
| CN106072516A (en) * | 2016-06-08 | 2016-11-09 | 李莉萍 | A kind of preparation method of Herba Dendrobii freeze-dried instant powder |
| CN109123623A (en) * | 2018-08-14 | 2019-01-04 | 福建新味食品有限公司 | A kind of processing method and application of dendrobium candidum |
| CN109223985A (en) * | 2018-11-06 | 2019-01-18 | 胡爱娣 | A kind of dendrobium candidum American Ginseng Ultramicro-powder microwave vacuum freeze drying means |
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