CN104906283A - Preparation method and application of acorus tatarinowii volatile oil microcapsule - Google Patents
Preparation method and application of acorus tatarinowii volatile oil microcapsule Download PDFInfo
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- CN104906283A CN104906283A CN201510270113.8A CN201510270113A CN104906283A CN 104906283 A CN104906283 A CN 104906283A CN 201510270113 A CN201510270113 A CN 201510270113A CN 104906283 A CN104906283 A CN 104906283A
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- volatile oil
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- rhizoma acori
- acori graminei
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Abstract
The invention relates to a preparation method and application of an acorus tatarinowii volatile oil microcapsule. According to the method, wall material maltodextrin and gelatin are dissolved in hot water with the temperature being 50-60 DEG C, stirred and dissolved, and a wall material solution is obtained; core material acorus tatarinowii volatile oil and an emulsifier are added into the wall material solution, and emulsion is obtained through homogenization; the emulsion is subjected to spray drying, and the acorus tatarinowii volatile oil microcapsule is prepared. The preparation method is simple, stability and dissolution dispersity are high, the microcapsule has the remarkable blood fat reducing function, and the method can be widely used for blood fat reducing medicine preparation.
Description
Technical field
The present invention relates to a kind of preparation method and application thereof of Rhizoma Acori Graminei volatile oil microcapsule.
Background technology
Rhizoma Acori Graminei is aroid, is used as medicine with dry rhizome, tool is had one's ideas straightened out, Fructus Alpiniae Oxyphyllae, eliminating phlegm, the function such as to invigorate blood circulation.Modern pharmacological research shows, it has the pharmacological actions such as immunity, antibacterial, anticancer, mutation, certain pharmacologically active is all had to central nervous system, cardiovascular system, respiratory system, digestive system etc., being widely used in the diseases such as epilepsy, convulsions, calentura coma, forgetful, senile dementia clinically, is encephalopathy good medicine few in number.Less to the research of its effect for reducing blood fat.
Its main active of Rhizoma Acori Graminei is Rhizoma Acori Graminei volatile oil, comprises
α-asaricin,
β-asaricin,
γthe many kinds of substances such as-asaricin, methyleugenol, cis methylisoeugenol.Rhizoma Acori Graminei volatile oil has penetrating odor, poorly water-soluble, and character is unstable, easily mutually transforms between each isomers, and under room temperature, the feature such as volatile, selects a kind of effective storage procedures to be also need the urgent problems solved.
Microcapsule technology refers to and utilizes macromolecule filming material to form after the solid of specifying or liquid embedding the embedding techniques that diameter is 1 ~ 1000 μm of particle.These solids be embedded, liquid are referred to as core, and its outer wall is called wall material.The microcapsule that core material is formed after embedding, has different new function in the past and character.The function of microcapsule mainly contains: one is the effect preventing or slow down the protection cores such as unstable core material volatilization, oxidation and corruption; But overcome some core material poor fluidities, not easily preserve, be inconvenient to the shortcoming of transporting; Three is bad smell or the taste of covering core material; Core material slow releasing etc. is made according to certain requirement.
Summary of the invention
The object of the invention is to for the deficiencies in the prior art, a kind of preparation method of Rhizoma Acori Graminei volatile oil microcapsule and the application in preparation treatment high blood cholesterol drug thereof are provided.
The present invention is achieved by following technical solution:
1. a preparation method for Rhizoma Acori Graminei volatile oil microcapsule, comprises the following steps:
A. wall material maltodextrin and gelatin are dissolved in the hot water of 50 ~ 60 DEG C of described wall material 1 ~ 3 times, stirring and dissolving, obtains wall material solution;
B. core Rhizoma Acori Graminei volatile oil and emulsifying agent sucrose ester are added in wall material solution, homogenizing obtains emulsion;
C. by emulsion spray drying, obtained Rhizoma Acori Graminei volatile oil microcapsule.
Wherein, each amounts of components accounts for the percentage by weight of all components total amount and is: Rhizoma Acori Graminei volatile oil 19 ~ 33%, emulsifying agent sucrose ester 1 ~ 3%, wall material 65 ~ 80%;
In wall material described in step a, the weight ratio of maltodextrin and gelatin is 3:1 ~ 2.
Homogenizing described in step b be adopt high pressure homogenize equipment by the wall material solution adding Rhizoma Acori Graminei volatile oil temperature be 70 ~ 80 DEG C, homogenizing 10min under the condition of pressure 15 ~ 25MPa.
Spray drying condition described in step c is: intake air temperature is 180 ~ 200 DEG C, and air outlet temperature is 80 ~ 90 DEG C, atomizing pressure 0.2MPa ~ 0.5MPa.
2. Rhizoma Acori Graminei volatile oil microcapsule microcapsule blood fat reducing effect experiment
A. laboratory animal SD male rat 50, body weight (190 ± 20) g
B. experimental technique
Rat is fed normal diet under experimental situation, and observe 5 ~ 10 days, caudal vein gets blood, centrifugal serum, measures every blood lipids index normal value.Random point 5 groups of rats, often organize 10, are respectively Normal group, hyperlipidemia model group, low dose group, middle dosage group and high dose group, and except Normal group, each treated animal is used high cholesterol diet instead and fed, the not administration of hyperlipidemia model group; Low dose group gavage gives sample 1g/kg; Middle dosage group gavage gives sample 2g/kg; High dose group gavage gives sample 4g/kg; Normal group and model group contrast with normal saline.After 6 weeks, eyeball gets hematometry indices, measures blood fat respectively every by zymetology and immunity projection turbidimetry.
C. date processing
Table 1 Rhizoma Acori Graminei volatile oil microcapsule is on the impact of rat fat
Compare with model group:
*p < 0.01
D. result
Can be found out by the experimental data in c, after testing 6 weeks, compared with hyperlipidemia model group, Serum TC level error heteropole significantly (P < 0.01), have dropped 39.9%, 46.1%, 74.2% respectively, illustrate that 3 dosage groups all can significantly reduce Serum TC level; The horizontal low dose group of TG and hyperlipidemia model group more in a slight decrease 16.4%, and middle and high dosage component is not for reducing 22.4% and 33.6%, effect is more obvious; Serum LDL-C also obviously reduces (P < 0.01), have dropped 33.02%, 44.8%, 61.4% respectively.Serum HDL-C is all a little more than model group, but difference with insignificance.This research confirms that Rhizoma Acori Graminei volatile oil microcapsule can make TC, LDC-C significantly reduce, though HPL-C level content improves not obvious, on the rise, illustrates that Rhizoma Acori Graminei volatile oil microcapsule has significant blood fat reducing function.
The invention has the advantages that: the microcapsule that (1) adopts the present invention to obtain, even particle size, and product has good heat stability and dissolution dispersity; (2) the Rhizoma Acori Graminei volatile oil microcapsule obtained by the present invention has obvious lipid-lowering effect.
Further illustrate the present invention below in conjunction with detailed description of the invention, but the scope of protection of present invention is not limited to following embodiments.
detailed description of the invention:
Embodiment 1:
Be the hot water that the maltodextrin of 3:1 and gelatin are dissolved in 50 DEG C of 65mL by the mass ratio of 65g, stirring and dissolving, obtains wall material solution; Add in wall material solution by the core Rhizoma Acori Graminei volatile oil of 33g and the emulsifying agent sucrose ester of 2g, homogenizing 10min under the condition of temperature 70 C, pressure 15MPa, obtains emulsion; By emulsion in intake air temperature be 180 DEG C, air outlet temperature is 90 DEG C, dry under the condition of atomizing pressure 0.5MPa, obtain Rhizoma Acori Graminei volatile oil microcapsule.
Embodiment 2:
Be 3:2's by the mass ratio of 70g
β-cyclodextrin and gelatin are dissolved in the hot water of 60 DEG C of 140mL, stirring and dissolving, obtain wall material solution; Add in wall material solution by the core Rhizoma Acori Graminei volatile oil of 27g and the emulsifying agent sucrose ester of 3g, homogenizing 10min under the condition of temperature 75 DEG C, pressure 20MPa, obtains emulsion; By emulsion in intake air temperature be 200 DEG C, air outlet temperature is 80 DEG C, dry under the condition of atomizing pressure 0.3MPa, obtain Rhizoma Acori Graminei volatile oil microcapsule.
Embodiment 3:
Be 3:2's by the mass ratio of 80g
β-cyclodextrin and gelatin are dissolved in the hot water of 55 DEG C of 240mL, stirring and dissolving, obtain wall material solution; Add in wall material solution by the core Rhizoma Acori Graminei volatile oil of 19g and the emulsifying agent sucrose ester of 1g, homogenizing 10min under the condition of temperature 80 DEG C, pressure 25MPa, obtains emulsion; By emulsion in intake air temperature be 190 DEG C, air outlet temperature is 85 DEG C, dry under the condition of atomizing pressure 0.2MPa, obtain Rhizoma Acori Graminei volatile oil microcapsule.
Claims (3)
1. the present invention relates to a kind of preparation method and application thereof of Rhizoma Acori Graminei volatile oil microcapsule.
2. the hot water of the present invention by wall material Fructus Hordei Germinatus cyclodextrin and gelatin being dissolved in 50 ~ 60 DEG C, stirring and dissolving, obtains wall material solution; Core Rhizoma Acori Graminei volatile oil and emulsifying agent are added in wall material solution, homogenizing obtains emulsion; By emulsion spray drying, obtained Rhizoma Acori Graminei volatile oil microcapsule.
3. preparation method of the present invention is simple, and stability and dissolution dispersity better, and have significant effect for reducing blood fat, can be widely used in and prepare in blood lipid-lowering medicine.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201510270113.8A CN104906283A (en) | 2015-05-26 | 2015-05-26 | Preparation method and application of acorus tatarinowii volatile oil microcapsule |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108142922A (en) * | 2018-02-01 | 2018-06-12 | 河北工程大学 | Reishi sporule powder capsule and preparation method thereof |
| CN112294969A (en) * | 2020-12-04 | 2021-02-02 | 首都医科大学附属北京朝阳医院 | Statin composition and application thereof in preparation of lipid-lowering medicines for inhibiting liver and kidney toxicity |
-
2015
- 2015-05-26 CN CN201510270113.8A patent/CN104906283A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108142922A (en) * | 2018-02-01 | 2018-06-12 | 河北工程大学 | Reishi sporule powder capsule and preparation method thereof |
| CN112294969A (en) * | 2020-12-04 | 2021-02-02 | 首都医科大学附属北京朝阳医院 | Statin composition and application thereof in preparation of lipid-lowering medicines for inhibiting liver and kidney toxicity |
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Application publication date: 20150916 |