CN104906256A - Traditional Chinese medicine composition for treating gout - Google Patents
Traditional Chinese medicine composition for treating gout Download PDFInfo
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- CN104906256A CN104906256A CN201510323872.6A CN201510323872A CN104906256A CN 104906256 A CN104906256 A CN 104906256A CN 201510323872 A CN201510323872 A CN 201510323872A CN 104906256 A CN104906256 A CN 104906256A
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Abstract
The invention provides a traditional Chinese medicine composition for treating gout. The traditional Chinese medicine composition prescription comprises the following raw materials in parts by weight: 2-20 parts of meadowrue root and rhizome, 2-16 parts of soulie barberry bark, 2-12 parts of radix sophorae flavescentis, 5-40 parts of lycopodium clavatum, 2-20 parts of buxus microphylla, 2-16 parts of cynoglossum furcatum and 3-18 parts of nightshade. The traditional Chinese medicine composition is capable of improving in-vivo purine metabolism due to excitation, and comprehensively recovering purines to a normal metabolism level; the traditional Chinese medicine composition is capable of rapidly relieving pain and diminishing swelling in case of an acute attack of gout, remarkable in curative effect, and free from any toxic and side effects, blood uric acid is not liable to rebound after stopping medicines, and the deposition of urate in joints and renal parenchyma is prevented. The traditional Chinese medicine composition is great in treatment effect on gout, is few in side effects, and is easily accepted by patients.
Description
Technical field
The present invention relates to a kind of Chinese medicine composition, be specifically related to a kind of Chinese medicine composition for the treatment of gout, belong to medical art.
Background technology
Gout be due to produce in body uric acid too much and kidney Scavenging activity decline, uric acid body accumulation, causes urate crystal in joint and each internal organs deposition.Along with improving constantly of people's living standard, the change of dietary structure and living habit (food being rich in nucleoprotein increases), the prolongation of average life, the understanding of the mankind to gout and the raising of diagnostic level, no matter be in American-European countries or in countries in Asia, the prevalence of gout has the trend increased year by year, current China Patients with Hyperuricemia number is more than 1.5 hundred million, wherein patient with gout is more than 7,500 ten thousand people, and increase with annual 0.97% annual rate of growth, gout has become China with the same second largest metabolism class disease of diabetes, and the life and health of people in serious threat.
Ancient Chinese medicine doctor can trace back to "Nei Jing" to the understanding of gout, therebetween the category being attributed to " pyretic arthralgia " more, and its head sees " during Plain Questions four the inverse opinion of thorn ", wherein also proposed the mechanism of pyretic arthralgia formation for " its hot person, yang-energy is many, and cloudy gas is few; pathogenic QI in the body is contained, and sun suffers the moon, therefore is numbness heat." so-called numbness heat, be pyretic arthralgia occur with arthroncus, scorching hot, pain, joint stuffiness, the numbness being clinical manifestation with heating is sick.Modern many doctors, on the basis of forefathers, by broad practice, to the etiology and pathogenesis of gout, TCM Syndrome Features, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs propose many useful opinions and understanding.The sick first professor of Wu thinks that this outbreak is that press from both sides inherent phlegm-damp and mutually hand over work, pathogen must not be fallen apart due to wind-cold damp pathogen resistance numbness passages through which vital energy circulates outward, strongly fragrantly holds back heat-transformation and causes acute articular to swell and ache in skin space between skin and muscles.Due to cold and heat interweave, inner for cold-damp resistance numbness, passages through which vital energy circulates QI and blood is obstructed, table for phlegm-damp hot and suffocating must not pent up fall apart outward, and send out this disease.
Current treatment gout still based on Western medicine, mainly contain: colchicine, Phenylbutazone or crovaril, indometacin, ibuprofen (ibvprofen, ibuprofen), piroxicam (piroxicanum), naproxen (naproxen congex), ACTH and prednisone etc.But said medicine can only stablize the state of an illness mostly, gout can not be effected a radical cure; Serious side effect also can be caused to cause the infringement of hepatic and renal function; Even if Emergent therapy effectively can not recur by symptom management, and drug resistance and repellence can be produced, even there will be leukopenia, cardiac function is impaired, hepatic and renal function is impaired, stimulating intestine and stomach system, aplastic anemia, cause the complication such as diabetes.These medicines are all defectiveness in treatment.Weak curative effect, side effect are large, the high bottleneck becoming its clinical practice for the treatment of cost.
Summary of the invention
The object of this invention is to provide one and treat gout Chinese medicine composition, this Chinese medicine composition is the traditional Chinese medical science side of demonstration medicine, that inventor is based on the pathogenetic understanding of Chinese medicine to gout, according to oneself clinical experience for many years, from numerous Chinese medicine, screen that prescription determines to obtain, this is by the defect of prescription compared with prior art Medicine use status quo, its have good effect, instant effect and can not recur, the beneficial effect such as side effect is little.
For achieving the above object, the invention provides following technical scheme:
Described a kind of Chinese medicine composition for the treatment of gout, is characterized in that these pharmaceutical composition prescription parts by weight are counted: Radix et Rhizoma Thalictri 2-20 part, Radix Berberidis soulieanae 2-16 part, Radix Sophorae Flavescentis 2-12 part, Herba Lycopodii 5-40 part, little Buxus sinica (Rehd.et Wils.) 2-20 part, Fructus Lithospermi Zollingeri 2-16 part, Herba Solani Nigri 3-18 part.
Particularly, described a kind of Chinese medicine composition for the treatment of gout, is characterized in that these pharmaceutical composition prescription parts by weight are counted: Radix et Rhizoma Thalictri 5-15 part, Radix Berberidis soulieanae 4-12 part, Radix Sophorae Flavescentis 3-9 part, Herba Lycopodii 10-30 part, little Buxus sinica (Rehd.et Wils.) 5-15 part, Fructus Lithospermi Zollingeri 4-12 part, Herba Solani Nigri 4.5-13.5 part.
More specifically, described a kind of Chinese medicine composition for the treatment of gout, is characterized in that these pharmaceutical composition prescription parts by weight are counted: Radix et Rhizoma Thalictri 10 parts, Radix Berberidis soulieanae 8 parts, Radix Sophorae Flavescentis 6 parts, Herba Lycopodii 20 parts, 10 parts, little Buxus sinica (Rehd.et Wils.), Fructus Lithospermi Zollingeri 8 parts, Herba Solani Nigri 9 parts.
Chinese medicine composition preparation method of the present invention is simple, can take after decocting by traditional method.In order to taking convenience, be prepared into various preparation after also can extracting Chinese medicine composition for clinical.
Another object of the present invention is to provide a kind of preparation method for the treatment of the Chinese medicine composition of gout, comprises the following steps:
Take the Radix et Rhizoma Thalictri of recipe quantity, Radix Berberidis soulieanae, Radix Sophorae Flavescentis, Herba Lycopodii, little Buxus sinica (Rehd.et Wils.), Fructus Lithospermi Zollingeri, Herba Solani Nigri seven taste crude drug, add soak by water three times, water consumption is 8-12 times of seven taste crude drug gross weights for the first time, decoct 3 hours, second time water consumption is 6-10 times of seven taste crude drug gross weights, decocts 2 hours, and water consumption is 4-8 times of seven taste crude drug gross weights for the third time, decoct 1 hour, merge decoction liquor, filter, filtrate is concentrated into thick paste, be spray dried to fine powder, obtained Chinese medicine composition extract.
After Chinese medicine composition extract of the present invention, can directly or indirectly add pharmaceutically acceptable adjuvant, make various oral formulations for clinical.
Wherein, described adjuvant can be binding agent, filler, tablet agent, diluent, wetting agent, disintegrating agent, coloring agent, flavoring agent, wetting agent or other medicinal carrier materials.
Wherein, described oral formulations dosage form includes but not limited to tablet, capsule, oral liquid, decoction, granule, electuary, pill, powder, sublimed preparation; Preferred decoction, oral liquid, granule, capsule, tablet.
When making decoction, preparation method comprises the following steps:
Above-mentioned obtained Chinese medicine composition extract is added distilled water and antiseptic, mix homogeneously, and pack, plastic packaging, every bag of 50ml, obtains decoction.
When making oral liquid, preparation method comprises the following steps:
Above-mentioned obtained Chinese medicine composition extract is added simple syrup and distilled water, and it is 15% that simple syrup adds to sugar content, and distilled water is supplemented to full dose, and fill often props up 10ml, obtains oral liquid.
When making granule, preparation method comprises the following steps:
Above-mentioned obtained Chinese medicine composition extract is added starch and sucrose, and with ethanol wet, the granulation of 70%-90%, dry, pack, every bag of 6g, namely obtains granule.
When making capsule, preparation method comprises the following steps:
Above-mentioned obtained Chinese medicine composition extract is added starch and sucrose, and with ethanol wet, the granulation of 70%-90%, dry, incapsulate, every heavy 0.6g of dress, namely obtains capsule.
When prepared as tablets, above-mentioned obtained Chinese medicine composition extract is added starch and magnesium stearate, with ethanol wet, the granulation of 80%, tabletting, hydroxypropyl emthylcellulose carries out coating, and every heavy 1g on chip, namely obtains tablet.
Beneficial effect of the present invention: the present invention treats the Chinese medicine composition of gout, that inventor is based on the pathogenetic understanding of Chinese medicine to gout, for the basic pathogenesis of the turbid stasis blocking of its wet hot phlegm, liver spleen renal dysfunction, and according to oneself clinical experience for many years, based on clearing away heat-damp and promoting diuresis, removing obstruction in the collateral to relieve pain, dual-purpose spleen invigorating, liver and kidney tonifying; First from numerous Chinese medicine, determine the effective Chinese medicine of a series for the treatment of gouts, more repeatedly verify through clinical, screen.Radix et Rhizoma Thalictri in side: bitter in the mouth, cold in nature, there is heat clearing and damp drying, effect of removing toxic substances; Radix Berberidis soulieanae: bitter in the mouth, cold in nature, heat-clearing and toxic substances removing, preventing phlegm from forming and stopping coughing; Radix Sophorae Flavescentis: bitter in the mouth, cold in nature, heat clearing and damp drying; Wind dispelling insecticide; Herba Lycopodii: bitter; Pungent; Temperature; Nontoxic, expelling wind and cold, dehumidifying detumescence, the effect of relaxing muscles and tendons to promote blood circulation; Little Buxus sinica (Rehd.et Wils.): bitter in the mouth, expelling wind and removing dampness, regulates the flow of vital energy, pain relieving; Fructus Lithospermi Zollingeri: lightly seasoned, cold in nature, heat-clearing and toxic substances removing, can control furuncle carbuncle, traumatic injury; Herba Solani Nigri: bitter in the mouth, cold in nature, there is heat-clearing and toxic substances removing, effect of promoting blood circulation and detumescence; 7 taste medicinal raw materials have Synergistic function by described proportioning combination, and through clinical research test, this Chinese medicine composition can make purine metabolism in body be excited and strengthen, and makes it to return to homergy level comprehensively.For the alleviating pain and detumescence rapidly of energy during gout acute attack, evident in efficacy, and without any side effects, after drug withdrawal, blood uric acid not easily rebounds, and prevents, in urate deposition joint and excess of the kidney matter, having good therapeutic effect to gout, and side effect is less, easily accepted by patient.
In order to the efficacy and saferry of proved invention medicine, inventors performed a series of pharmacodynamics and toxicity test investigation.The research method adopted and result of the test as follows:
Test example 1: the screening test of prescription of the present invention:
The present inventor with theory of Chinese medical science basis, and according to oneself clinical experience for many years, has carried out a large amount of prescription screening tests, with preferentially for target, has considered the curative effect of prescription, safety, has carried out following prescription test:
Test method: investigate the inhibitory action of each prescription on the swelling of Gout Model rat articular and the impact of blood uric acid
1, animal model and administration
Get the male rat 80 that body weight is 250-280g, weigh after adapting to laboratory 5d, number, be divided into 8 groups at random, often organize 10, be: Normal group, model group, positive drug group (allopurinol), each prescription test group 1-5; Wherein test group is:
Test group 1: administration prescription is: Radix et Rhizoma Thalictri 15g, Herba Lycopodii 25g, Radix Sophorae Flavescentis 8g, Herba Solani Nigri 12g;
Test group 2: administration prescription is: Herba Lycopodii 30g, little Buxus sinica (Rehd.et Wils.) 15g, Fructus Lithospermi Zollingeri 12g, Radix Berberidis soulieanae 8g;
Test group 3: administration prescription is: Radix et Rhizoma Thalictri 15g, Radix Berberidis soulieanae 10g, Radix Sophorae Flavescentis 10g, Herba Lycopodii 20g, little Buxus sinica (Rehd.et Wils.) 10g;
Test group 4: administration prescription is: Radix et Rhizoma Thalictri 15g, Radix Berberidis soulieanae 8g, Radix Sophorae Flavescentis 8g, Herba Solani Nigri 12g, Herba Lycopodii 20g, little Buxus sinica (Rehd.et Wils.) 10g;
Test group 5: Radix et Rhizoma Thalictri 12g, Radix Berberidis soulieanae 7g, Radix Sophorae Flavescentis 5g, Herba Lycopodii 18g, little Buxus sinica (Rehd.et Wils.) 8g, Herba Solani Nigri 12g, Fructus Lithospermi Zollingeri 10g.
Each group 8 times amount soak by water 3 times above, each 2 hours, collecting decoction also concentrated and makes thick paste, stand-by.
Above-mentioned each prescription test group dosage is 4g crude drug/kg, makes the 5ml solution of same volume, the distilled water of the capacity such as Normal group and model group gavage, administration every day 1 time, continuous gavage 5d.
Except normal group, every experimental mouse all selects right Ankle lateral rear to be point of puncture, and pin mouth inclined-plane penetrates ankle joint chamber towards front upper place and tibia angle at 45 °, injects 0.2ml Monosodium urate solution to articular cavity, heave for injection standard with joint capsule offside, induction Gout Model.Each group of rat 3h before modeling, after modeling, and after medication 5d (i.e. 120h after modeling) respectively in tested ankle joint same area, with its diameter of vernier caliper measurement, observe before and after modeling and each group tested joint diameter change after medication treatment, after last administration, 2h puts to death rat, abdominal aortic blood, 2500r/min, centrifugal 5min, gets determination of serum uric acid level, carries out group difference and compares.Result of the test is as following table 1:
Table 1: the inhibitory action of prescription on the swelling of Gout Model rat articular and the impact of blood uric acid
Upper table display: the present invention carries out screening test through animal experiment to prescription, found that, the prescription of the test group 5 be made up of Radix et Rhizoma Thalictri, Radix Berberidis soulieanae, Radix Sophorae Flavescentis, Herba Lycopodii, little Buxus sinica (Rehd.et Wils.), Herba Solani Nigri, Fructus Lithospermi Zollingeri seven taste Chinese medicine, it is best to the impact effect of the inhibitory action of Gout Model rat articular swelling and blood uric acid, therefore, seven taste Chinese medicines compositions of the preferred Radix et Rhizoma Thalictri of the present invention, Radix Berberidis soulieanae, Radix Sophorae Flavescentis, Herba Lycopodii, little Buxus sinica (Rehd.et Wils.), Herba Solani Nigri and Fructus Lithospermi Zollingeri, investigate the prescription consumption proportion of a medical material further.
Test example 2: Chinese medicine composition pharmacodynamic study of the present invention---prescription consumption screens.
1, test material:
(1) medicine and reagent:
The Chinese medicine composition (embodiment 1-embodiment 5) that the present invention obtains;
Colchicine: be Yunnan Plant Pharmaceutical Industry Co., Ltd.'s product;
(2) animal: Kunming mouse, SD rat, provided by unming Medical College;
2, test method and result
(1) on the impact of hyperuricemia Mouse Blood uric acid level
Get Kunming mouse 80, male and female are use all, and body weight 25 ~ 32g is divided into 8 groups at random, and often organize 10, first group is normal saline group, and second group is Medications Example group of the present invention 1,3,5,6,7, the 3rd group is positive controls, and the 4th group is model group.
5ml normal saline is gavaged to first group; Second group gavages the Chinese medicine composition of the embodiment of the present invention 1,3,5,6,7 preparation respectively by the dosage of 4g crude drug/kg, and adding water before gavage or after concentrating or grinding is mixed with the 5ml solution of same volume; 3rd group gavages colchicine by the drug dose of 0.1mg/kg, does not do any process for the 4th group, every day 1 time, continuous 4d.
After last administration 1h, except normal saline group, all the other each group, animal Intraperitoneal injection of hypoxanthine 1mg/kg, causes mice hyperuricemia, and normal saline group presses 1mg/kg injecting normal saline.0.5h after injection, plucks eyeball to each treated animal and gets blood, and the blood obtained after centrifugal 15min, is got serum and surveyed Level of Serum Uric Acid under the speed conditions of 3000r/min.After treatment, the statistical result of blood uric acid measured value is as shown in table 1 for each experimental group and matched group.
Table 2: medicine is on the impact of hyperuricemia Mouse Blood uric acid level
| Group | Quantity (only) | Level of Serum Uric Acid (umol/l) |
| Normal saline group | 10 | 112.03±21.3 |
| Model group | 10 | 522.03±83.2 |
| Positive control test group | 10 | 156.43±32.6 |
| Embodiment 1 | 10 | 142.3±26.7 |
| Embodiment 3 | 10 | 168.16±29.5 |
| Embodiment 5 | 10 | 157.3±30.2 |
| Embodiment 6 | 10 | 212.11±34.2 |
| Embodiment 7 | 10 | 161.62±29.4 |
Upper table 2 shows: compare in model group, the Level of Serum Uric Acid that Medications Example of the present invention 1,3,5,7 groups records Level of Serum Uric Acid relative model group and records, and has obvious reduction, and effect is better than or close with colchicine group effect; The low formula consumption group less effective of embodiment 6, the high formula consumption of embodiment 7 does not obtain better effect, and the consumption increase of medicine has certain security risk, therefore, suggestion adopts prescription amount ranges of the present invention, have good curative effect, and economy, safety is good in treatment gout.
The clinical research of experimental example 3 Chinese medicine composition of the present invention
All cases are all with reference to 1977 " diagnostic criteria that American Rheumatism Association formulates " and China's " Chinese medical disease Standardization of diagnosis and curative effect " totally 53 examples, and wherein male 46 is routine, women 7 example; Minimum 22 years old of age, maximum 62 years old; The course of disease is the shortest 13 days, the longest 9 years, maximum with 3-5; The wherein Metatarsophalangeal joint person of swelling and ache 40 example, wherein side 37 example, both sides 13 example.One-sided arthritis 32 example, has two arthralgia inflammation person 14 examples, has tophus person 6 example.All cases all by experiment room check, blood uric acid increases 50 examples, and in example normal range 3, all patients get rid of medicine and other disease secondary.
Therapeutic Method:
All adopt the preparation that embodiments of the invention are obtained.Wherein 40 examples take the obtained decoction of the embodiment of the present invention 1,3 times on the one, each 1 bag; 7 examples take the obtained oral liquid of the embodiment of the present invention 2,3 times on the one, each 10ml; 6 examples take the obtained capsule of the invention process 4, every day three times, each 3.Within 7 days, be a course for the treatment of, take observe the curative effect after 3-4 the course for the treatment of.Few movable therebetween, alleviating alcohol addiction, does not enter high purine food.
Efficacy assessment standard:
Recovery from illness: clinical symptoms all disappears, and freely, blood uric acid is down to normal range to joint motion; Effective: clinical symptoms takes a turn for the better, joint motion is flexible, and blood uric acid is comparatively front reduces by more than 10%; Invalid: symptom and lab testing unchanged.
Result:
Recovery from illness: 46 examples account for 86.8%; Effective: 6 examples account for 11.32%; Invalid: 1 example 1.8%; Total effective rate is 98.2%.
Model case:
Lee, man, 47 years old, From Anshun of Guizhou people, patient feels to feel run-down throughout the year, hydrarthrosis, and myalgia, occurs acute pain once in a while, and half of numbness of hands and feet is handicapped, is gout through hospital diagnosis; Take some Chinese medicines to treat, DeGrain; Take the granule prepared by the embodiment of the present invention 5 subsequently, daily 3 times, each serving with 5g, after taking 3 courses for the treatment of continuously, arthroncus disappears, and the state of an illness is clearly better, and continues to take 3 courses for the treatment of, and recovery from illness, follows up a case by regular visits to after 1 year and do not recur.
Section certain, female, 32 years old, people from Kweiyang, Guizhou, there is edema burning pain phenomenon in patient brothers joint, night is often waken up bitterly, and especially rainy day more very, is gout through hospital diagnosis; After taking Western medicine, symptom has alleviation, but recurs again afterwards; Take the tablet of the embodiment of the present invention 3 subsequently, every day 3 times, each 3, after taking 1 month continuously, recovery from illness, follows up a case by regular visits to after 1 year half and does not recur.
Above-mentioned test proves: Chinese medicine composition of the present invention and preparation thereof, Be very effective in treatment gout, and side effect is little, and prescription is exquisite, and preparation method is simple, the very large production of suitability for industrialized.
Detailed description of the invention:
Embodiment 1: the preparation of decoction
Take Radix et Rhizoma Thalictri 100g, Radix Berberidis soulieanae 80g, Radix Sophorae Flavescentis 60g, Herba Lycopodii 200g, little Buxus sinica (Rehd.et Wils.) 100g, Fructus Lithospermi Zollingeri 80g, Herba Solani Nigri 90g seven taste crude drug, add soak by water three times, water consumption is 10 times of seven taste crude drug gross weights for the first time, decoct 3 hours, second time water consumption is 8 times of seven taste crude drug gross weights, decoct 2 hours, water consumption is 6 times of seven taste crude drug gross weights for the third time, decoct 1 hour, merge decoction liquor, filter, filtrate is concentrated into thick paste, be spray dried to fine powder, obtained Chinese medicine composition extract;
It is 5000ml that above-mentioned obtained Chinese medicine composition extract is added distilled water to liquor capacity, adds the potassium sorbate of 0.5%, mix homogeneously, and pack, plastic packaging, every bag of 50ml, obtains decoction.
Usage and dosage: oral, each 1 bag, every day three times.
Embodiment 2: the preparation of oral liquid
Take Radix et Rhizoma Thalictri 150g, Radix Berberidis soulieanae 120g, Radix Sophorae Flavescentis 90g, Herba Lycopodii 300g, little Buxus sinica (Rehd.et Wils.) 150g, Fructus Lithospermi Zollingeri 120g, Herba Solani Nigri 135g seven taste crude drug, add soak by water three times, water consumption is 10 times of seven taste crude drug gross weights for the first time, decoct 3 hours, second time water consumption is 8 times of seven taste crude drug gross weights, decoct 2 hours, water consumption is 6 times of seven taste crude drug gross weights for the third time, decoct 1 hour, merge decoction liquor, filter, filtrate is concentrated into thick paste, be spray dried to fine powder, obtained Chinese medicine composition extract;
Above-mentioned obtained Chinese medicine composition extract is added simple syrup and distilled water, regulate sugar content to be 15%, and liquor capacity is 1000ml, adds the potassium sorbate of 0.5%, mix homogeneously, fill, obtains oral liquid.Often only fill 10ml.
Usage and dosage: oral, each 1, every day three times.
Embodiment 3: the preparation of tablet
Take Radix et Rhizoma Thalictri 20g, Radix Berberidis soulieanae 20g, Radix Sophorae Flavescentis 20g, Herba Lycopodii 50g, little Buxus sinica (Rehd.et Wils.) 20g, Fructus Lithospermi Zollingeri 20g, Herba Solani Nigri 30g seven taste crude drug, add soak by water three times, water consumption is 10 times of seven taste crude drug gross weights for the first time, decoct 3 hours, second time water consumption is 8 times of seven taste crude drug gross weights, decoct 2 hours, water consumption is 6 times of seven taste crude drug gross weights for the third time, decoct 1 hour, merge decoction liquor, filter, filtrate is concentrated into thick paste, be spray dried to fine powder, obtained Chinese medicine composition extract;
Above-mentioned obtained Chinese medicine composition extract is added 30g microcrystalline Cellulose, and supplying starch to gross weight is 150g, with ethanol wet, the granulation of 80%, dry, then 10g magnesium stearate is added, mixing, tabletting, coating is carried out, obtained 300, tablet, the heavy 0.5g of every sheet with hydroxypropyl emthylcellulose.
Usage and dosage: oral, each 3, every day three times.
Embodiment 4: the preparation of capsule
Take Radix et Rhizoma Thalictri 50g, Radix Berberidis soulieanae 40g, Radix Sophorae Flavescentis 30g, Herba Lycopodii 100g, little Buxus sinica (Rehd.et Wils.) 50g, Fructus Lithospermi Zollingeri 40g, Herba Solani Nigri 45g seven taste crude drug, add soak by water three times, water consumption is 10 times of seven taste crude drug gross weights for the first time, decoct 3 hours, second time water consumption is 8 times of seven taste crude drug gross weights, decoct 2 hours, water consumption is 6 times of seven taste crude drug gross weights for the third time, decoct 1 hour, merge decoction liquor, filter, filtrate is concentrated into thick paste, be spray dried to fine powder, obtained Chinese medicine composition extract;
Above-mentioned obtained Chinese medicine composition extract is added microcrystalline Cellulose 20g, and starch complements to total amount 180g, the ethanol wet of 80%, granulation, dry, then adds 12g magnesium stearate, and mixing, incapsulates, obtained capsule 300.Every heavy 0.6g.
Usage and dosage: oral, each 3, every day three times.
Embodiment 5: the preparation of granule
Take Radix et Rhizoma Thalictri 200g, Radix Berberidis soulieanae 160g, Radix Sophorae Flavescentis 120g, Herba Lycopodii 400g, little Buxus sinica (Rehd.et Wils.) 200g, Fructus Lithospermi Zollingeri 160g, Herba Solani Nigri 180g seven taste crude drug, add soak by water three times, water consumption is 10 times of seven taste crude drug gross weights for the first time, decoct 3 hours, second time water consumption is 8 times of seven taste crude drug gross weights, decoct 2 hours, water consumption is 6 times of seven taste crude drug gross weights for the third time, decoct 1 hour, merge decoction liquor, filter, filtrate is concentrated into thick paste, be spray dried to fine powder, obtained Chinese medicine composition extract;
Above-mentioned obtained Chinese medicine composition extract is added sucrose 150g, supplies starch to 500g, the ethanol wet of 80%, granulation, dry, pack, obtained granule 100 bags, every bag of 5g.
Embodiment 6: the decoction of low amounts of components
Method for making is with embodiment 1, and prescription proportioning is: Radix et Rhizoma Thalictri 10g, Radix Berberidis soulieanae 10g, Radix Sophorae Flavescentis 10g, Herba Lycopodii 40g, little Buxus sinica (Rehd.et Wils.) 10g, Fructus Lithospermi Zollingeri 10g, Herba Solani Nigri 20g
Embodiment 7: the decoction of high amounts of components
Method for making is with embodiment 1, and prescription proportioning is: Radix et Rhizoma Thalictri 220g, Radix Berberidis soulieanae 180g, Radix Sophorae Flavescentis 150g, Herba Lycopodii 450g, little Buxus sinica (Rehd.et Wils.) 230g, Fructus Lithospermi Zollingeri 180g, Herba Solani Nigri 200g.
Claims (10)
1. treat a Chinese medicine composition for gout, it is characterized in that: described Chinese medicine composition prescription parts by weight are counted: Radix et Rhizoma Thalictri 2-20 part, Radix Berberidis soulieanae 2-16 part, Radix Sophorae Flavescentis 2-12 part, Herba Lycopodii 5-40 part, little Buxus sinica (Rehd.et Wils.) 2-20 part, Fructus Lithospermi Zollingeri 2-16 part, Herba Solani Nigri 3-18 part.
2. the Chinese medicine composition of the treatment gout according to claims 1, is characterized in that: Chinese medicine composition prescription parts by weight are counted: Radix et Rhizoma Thalictri 5-15 part, Radix Berberidis soulieanae 4-12 part, Radix Sophorae Flavescentis 3-9 part, Herba Lycopodii 10-30 part, little Buxus sinica (Rehd.et Wils.) 5-15 part, Fructus Lithospermi Zollingeri 4-12 part, Herba Solani Nigri 4.5-13.5 part.
3. the Chinese medicine composition for the treatment of gout according to claim 1, is characterized in that: Chinese medicine composition prescription parts by weight are counted: Radix et Rhizoma Thalictri 10 parts, Radix Berberidis soulieanae 8 parts, Radix Sophorae Flavescentis 6 parts, Herba Lycopodii 20 parts, 10 parts, little Buxus sinica (Rehd.et Wils.), Fructus Lithospermi Zollingeri 8 parts, Herba Solani Nigri 9 parts.
4. the Chinese medicine composition of the treatment gout according to any one of claim 1-3, is characterized in that: described preparation method comprises the following steps:
Take the Radix et Rhizoma Thalictri of recipe quantity, Radix Berberidis soulieanae, Radix Sophorae Flavescentis, Herba Lycopodii, little Buxus sinica (Rehd.et Wils.), Fructus Lithospermi Zollingeri, Herba Solani Nigri seven taste crude drug, add soak by water three times, water consumption is 8-12 times of seven taste crude drug gross weights for the first time, decoct 3 hours, second time water consumption is 6-10 times of seven taste crude drug gross weights, decocts 2 hours, and water consumption is 4-8 times of seven taste crude drug gross weights for the third time, decoct 1 hour, merge decoction liquor, filter, filtrate is concentrated into thick paste, be spray dried to fine powder, obtained Chinese medicine composition extract.
5. the Chinese medicine composition for the treatment of gout according to claim 4, is characterized in that: described Chinese medicine composition, after extracting, directly or indirectly adds pharmaceutically acceptable adjuvant, makes oral formulations for clinical.
6. the Chinese medicine composition for the treatment of gout according to claim 5, is characterized in that: described adjuvant can be pharmaceutically acceptable binding agent, filler, tablet agent, diluent, wetting agent, disintegrating agent, coloring agent, flavoring agent, wetting agent or other medicinal carrier materials.
7. the Chinese medicine composition for the treatment of gout according to claim 5, is characterized in that: the dosage form of described oral formulations includes but not limited to tablet, capsule, oral liquid, granule, pill, powder, sublimed preparation.
8. the Chinese medicine composition for the treatment of gout according to claim 7, is characterized in that: described dosage form is granule, capsule, tablet.
9. the Chinese medicine composition for the treatment of gout according to claim 7, it is characterized in that: the preparation method of described decoction comprises the following steps: the Chinese medicine composition extract that claim 4 is obtained adds distilled water and antiseptic, mix homogeneously, pack, plastic packaging, obtains decoction.
10. the Chinese medicine composition for the treatment of gout according to claim 7, it is characterized in that: the preparation method of described oral liquid comprises the following steps: the Chinese medicine composition extract that claim 4 is obtained adds simple syrup and distilled water, it is 15% that simple syrup adds to sugar content, distilled water is supplemented to full dose, fill, obtains oral liquid.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106139009A (en) * | 2016-08-03 | 2016-11-23 | 韩洁茹 | A kind of Chinese medicine composition purposes in the medicine of preparation treatment chronic gout |
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| CN104055876A (en) * | 2014-06-16 | 2014-09-24 | 万伦 | Traditional Chinese medicinal composition for treating gout and oral preparation and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106139009A (en) * | 2016-08-03 | 2016-11-23 | 韩洁茹 | A kind of Chinese medicine composition purposes in the medicine of preparation treatment chronic gout |
| CN106139009B (en) * | 2016-08-03 | 2018-05-29 | 黑龙江中医药大学 | A kind of purposes of Chinese traditional medicine composition in the drug for preparing treatment chronic gout |
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Application publication date: 20150916 |