CN104906131A - Preparation method of plaster preparation for preventing and treating lamb stomatitis - Google Patents
Preparation method of plaster preparation for preventing and treating lamb stomatitis Download PDFInfo
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- CN104906131A CN104906131A CN201510320474.9A CN201510320474A CN104906131A CN 104906131 A CN104906131 A CN 104906131A CN 201510320474 A CN201510320474 A CN 201510320474A CN 104906131 A CN104906131 A CN 104906131A
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Abstract
The invention discloses a preparation method of a plaster preparation for preventing and treating lamb stomatitis. The preparation method comprises the following steps of (1) dissolving 1-3g of menthol into 25-75ml of iodine tincture to obtain an iodine tincture and menthol solution; (2) weighing 25-75ml of glycerin, and uniformly mixing the glycerin and the iodine tincture and menthol solution prepared in the step (1) to obtain a mixed solution; (3) weighing 1-3g of xanthan gum, dissolving the xanthan gum into 25-75ml of water, and sufficiently dissolving to obtain a jelly; and (4) sufficiently mixing the mixed solution obtained in the step (2) and the jelly prepared in the step (3) to obtain the plaster preparation. The plaster preparation is mainly used for external application for preventing and treating lamb stomatitis, is capable of diminishing inflammation, relieving pain, relieving itching, promoting blood circulation and relieving edema, and has a bacterium and virus killing effect.
Description
Technical field
The invention belongs to veterinary drug technical field, be specifically related to a kind of preparation method of preventing and treating lamb stomatitis plaster.
Background technology
Sheep stomatitis is the inflammation of oral mucosa top layer and deep tissues.In pathological process, oral mucosa and gingival inflammation, disease sheep can be made to search for food and dysmasesis, and watery saliva flowing from the mouth, sensitivity to pain increases.Clinical common pure local inflammation and Secondary cases general reaction.New-bom lamb is main within one week relies on suckling to obtain nutrition, after one week, along with lamb grows up gradually, starts to imitate ewe and to search for food the object of feedstuff, the various shape that bites.But the oral area due to new-bom lamb is mucocutaneous delicate especially, as easy as rolling off a log injured breakage, infected rear generation stomatitis.Once infection stomatitis, sick sheep performance poor appetite, sialorrhea in mouth, chews slowly, is reluctant to search for food due to pain, sometimes also can secondary halitosis.As fruit disease sheep can not be cured timely, sick sheep will occur loss of appetite even completely without, ruminate minimizing, become thin in a jumble, gradually by hair is unglazed, finally cause disease lamb to be died of hunger.
At present in sheep raising produces, control lamb stomatitis mainly uses some disinfectant, as slight stomatitis can with 0.1% ethacridine or 0.1% potassium permanganate solution washing oral cavity, can also with the Alumen flushing of 2%; Occur rotten to the corn with when oozing out, the Alumen with 2% rinses; When oral mucosa has ulcer, available iodine glycerol, 5% iodine tincture, aldrich mixture, sulfanilamide ointment, tetracycline ointment etc. embrocate affected part; As secondary bacterial infection, when sick sheep body temperature raises, available penicillin, streptomycin etc. carry out intramuscular injection, every day 2 times, are used in conjunction 3 ~ 5 days, also can take or inject sulfa drugs.
Prevent and treat in the process of lamb stomatitis utilizing above method and find, what above-described all kinds of common disinfectants had is not easy to adhere at disease sites, more can not form the covering of protectiveness at patient part, thus can not stop longer time performance drug effect at disease sites, curative effect is slower; Other, if sulfonamides, Tetracyclines ointment are due to its bitter in the mouth, have certain zest to lamb, and often use is easily developed immunity to drugs.And the use of antibiotics, be easy to again to cause to resist (resistance to) property of medicine and the residual problem such as to exceed standard of cultivation class medicine, even affect the development of breast of ewe lamb, do not meet animal welfare, development non-nuisance industry, produce the demand of green aquatic product.
Summary of the invention
For the technological deficiency existed in prior art control lamb stomatitis, the object of the present invention is to provide a kind of preparation method of ointment of control lamb stomatitis of with low cost, easy to use, Be very effective, ointment practical application prepared by the present invention is effective, cost is low, easy processing, has good market prospect.
The present invention realizes especially by following technical scheme:
Prevent and treat a preparation method for lamb stomatitis plaster, comprise the following steps:
1) 1 ~ 3g Mentholum is dissolved in 25 ~ 75ml iodine tincture, obtains iodine tincture Mentholum solution;
2) measure the iodine tincture Mentholum solution that the glycerol of 25 ~ 75ml and step (1) make to mix, obtain mixed solution;
3) take 1 ~ 3g xanthan gum to be dissolved in 25 ~ 75ml water, fully dissolve, obtain jelly;
4) step (2) is obtained mixed solution fully to mix with the jelly that (3) step is made, to obtain final product.
In described iodine tincture, the mass concentration of iodine is 20g/L, i.e. the iodine tincture of 2%.
To the lamb stomatitis in 60 ages in days after described ointment is mainly used in treating and is born.
Preferably, a kind of preparation method of preventing and treating lamb stomatitis plaster, comprises the following steps:
1) 2g Mentholum being dissolved in 50ml concentration is in the iodine tincture of 2%, obtains iodine tincture Mentholum solution;
2) measure the iodine tincture Mentholum solution that the glycerol of 50ml and step (1) make to mix, obtain mixed solution;
3) take 2g xanthan gum to be dissolved in 50ml water, fully dissolve, obtain jelly;
4) step (2) is obtained mixed solution fully to mix with the jelly that (3) step is made, to obtain final product.
In described iodine tincture, the mass concentration of iodine is 20g/L, i.e. the iodine tincture of 2%.
Ointment preparation prepared by the inventive method is also within the scope of protection of the invention.To the lamb stomatitis in 60 ages in days after described ointment preparation is mainly used in preventing and treating and is born.
Iodine tincture in ointment of the present invention, iodine tincture is commonly called as iodine tincture, medically generally claims iodine tincture, is the disinfection preservative for skin infection and sterilization, is 2% solution being dissolved in ethanol by iodine, potassium iodide and being made.Its mechanism of action makes bacterium protein degeneration, dead, all has killing action to antibacterial, virus.Before the function of iodine tincture is mainly used as skin and injection, the sterilization of operative site.
Glycerol, glycerol is that odorless, has warm sweet taste, be commonly called as glycerol, can absorb moisture from air without color and taste sweet clear and bright thick liquid, is the constituent of multiple skincare product.
Mentholum, a kind of chemical agent, Mentholum system extracted by the leaf of Herba Menthae and stem, white crystal, molecular formula C
10h
20o is the main component in Herba Menthae and lavender quintessence oil.In the world, India is main natural Herba Menthae manufacturing country.Mentholum and racementhol all can be used as toothpaste; Perfume; The odorant of beverage and confection etc.Being pharmaceutically used as excitants, acting on skin or mucosa, having refrigerant itching-relieving action; Take orally and can be used as carminative, for headache and nose; Pharynx; Laryngitis etc.Its ester is used for spice and medicine.Herba Menthae brain-capacity optionally stimulates the Cold receptor of human body skin or mucosa, produces sense of cold reflection and creeping chill, causes skin mucosa vasoconstriction (in fact skin keeps normal); Also can cause contraction to the blood vessel of deep tissue in addition, and produce therapeutical effect.External can antiinflammatory, and pain relieving, antipruritic, blood circulation promoting, alleviates edema etc.
Xanthan gum, also known as Xanthan gum, HANSHENGJIAO, Xanthan Gum a kind ofly to be fermented the monospore polysaccharide produced by false xanthomonas, is primary raw material by cabbage black rot xanthomonas campestris with carbohydrate, through aerobic fermentation biotechnology, cut off 1,6-glycosidic bond, after opening side chain, by the outer heteropolysaccharide of the acid born of the same parents of the one of Isosorbide-5-Nitrae-be bonded to straight chain composition.Xanthan gum sends out liquor-saturated by saccharide through Xanthomonas campestris, the outer many pools of microorganism of born of the same parents of generation.Due to its macromole special construction and colloid property, and there is several functions, can be used as emulsifying agent, stabilizing agent, gelling thickener, wetting agent, film forming agent etc.Xanthan gum is described as " industrial monosodium glutamate ", is the current maximum and purposes microbial polysaccharide very widely of production scale in the world.In pharmaceutical products, can be used as setting agent, suspending agent, wetting agent, there is thickening, attachment, lubrication, improve the adhesion property of unguentum, good dispersion.
Beneficial effect of the present invention is: ointment of the present invention, can antiinflammatory based on heat-clearing and toxic substances removing, pain relieving, and antipruritic, blood circulation promoting, alleviates edema, all has killing action to antibacterial, virus, has significant curative effect for after treatment birth to the lamb stomatitis in 60 ages in days.Unguentum of the present invention is easy to use simultaneously, has long-acting, convenient and simple, and preparation process is simple, is easy to promote the use of.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described further, the following stated, only to preferred embodiment of the present invention, not do other forms of restriction to the present invention, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed to the Equivalent embodiments of equal change.Everyly do not depart from the present invention program's content, any simple modification done following examples according to technical spirit of the present invention or equivalent variations, all drop in protection scope of the present invention.
Embodiment 1
Prevent and treat a plaster for lamb stomatitis, consist of the following composition: iodine tincture 50ml, glycerol 50ml, Mentholum 2g, xanthan gum 2g, pure water 50ml.
Prepare by the following method:
1) 2g Mentholum being dissolved in 50ml concentration is in the iodine tincture of 2%, obtains iodine tincture Mentholum solution;
2) measure the iodine tincture Mentholum solution that the glycerol of 50ml and step (1) make to mix, obtain mixed solution;
3) take 2g xanthan gum to be dissolved in 50ml water, fully dissolve, obtain jelly;
4) step (2) is obtained mixed solution fully to mix with the jelly that (3) step is made, to obtain final product.
Embodiment 2
Prevent and treat a plaster for lamb stomatitis, consist of the following composition: iodine tincture 25ml, glycerol 75ml, Mentholum 1g, xanthan gum 3g, pure water 25ml.
Prepare by the following method:
1) 1g Mentholum being dissolved in 25ml concentration is in the iodine tincture of 2%, obtains iodine tincture Mentholum solution;
2) measure the iodine tincture Mentholum solution that the glycerol of 75ml and step (1) make to mix, obtain mixed solution;
3) take 3g xanthan gum to be dissolved in 25ml water, fully dissolve, obtain jelly;
4) step (2) is obtained mixed solution fully to mix with the jelly that (3) step is made, to obtain final product.
Embodiment 3
Prevent and treat a plaster for lamb stomatitis, consist of the following composition: iodine tincture 75ml, glycerol 25ml, Mentholum 3g, xanthan gum 1g, pure water 75ml.
Prepare by the following method:
1) 3g Mentholum being dissolved in 75ml concentration is in the iodine tincture of 2%, obtains iodine tincture Mentholum solution;
2) measure the iodine tincture Mentholum solution that the glycerol of 25ml and step (1) make to mix, obtain mixed solution;
3) take 1g xanthan gum to be dissolved in 75ml water, fully dissolve, obtain jelly;
4) step (2) is obtained mixed solution fully to mix with the jelly that (3) step is made, to obtain final product.
Be described further below in conjunction with the therapeutic effect of specific embodiment to ointment of the present invention.
Embodiment 4 therapeutic effect is tested
To the lamb in 60 ages in days after Qingdao of Shandong province Laoshan District milk goat plant chooses birth, therefrom select the lamb suffering from stomatitis 200 after making a definite diagnosis as treatment target, the lamb 200 of random choose being suffered from stomatitis is divided into 4 groups (embodiment 1 group, embodiment 2 groups, embodiment 3 groups and matched groups), often organize 50, wherein embodiment 1 ~ 3 group uses the embodiment of the present invention 1 ~ 3 gained plaster to treat respectively, in site of disease application during night, change dressings every day once; Matched group adopts western medicine, 25 tablets of metronidazoles of every sheet net weight 0.2g are ground into powder, be mixed in 30ml warm water and stir, finally add 70ml glycerol and be hybridly prepared into the metronidazole glycerine mixture that concentration is 0.5%, after first rinsing disease sheep oral cavity with concentration 0.2% potassium permanganate, metronidazole glycerine mixture is embrocated, every day each 1 time sooner or later at its affected part.Observed and recorded respectively organizes cure rate and the healing time of sheep, and result is as shown in table 1.
Curative effect determinate standard:
Recovery from illness: suffer from sheep after the treatment of 1 week, its Oral symptoms disappears, and can normally take food, temperature recovery is normal.
Effective: the Oral symptoms of suffering from sheep disappears substantially, food-intake compares increase with before treatment, and temperature recovery is normal.
Invalid: suffer from sheep after the treatment of 1 week, its Oral symptoms still exists, and body temperature is higher, and food-intake is without increase.
Table 1 therapeutic effect is added up
| Grouping | Embodiment 1 | Embodiment 2 | Embodiment 3 | Matched group |
| Recovery from illness | 49 | 45 | 46 | 30 |
| Effectively | 1 | 4 | 4 | 11 |
| Invalid | 0 | 1 | 0 | 9 |
| Recovery from illness natural law | 3 | 3 | 3 | 7 |
Data from table 1: plaster of the present invention is obviously better than western medicine group to sheep stomatitis therapeutic effect, Experiment on therapy is significantly shorter than matched group simultaneously, illustrates that plaster of the present invention has positive effect on the long-acting of medicine and absorption.
Embodiment 5 prevention effect is tested
The firm postnatal healthy lamb 200 of Qingdao of Shandong province Laoshan District milk goat plant random selecting, 200 of random choose lambs are divided into 4 groups (embodiment 1 group, embodiment 2 groups, embodiment 3 groups and matched groups), often organize 50, wherein embodiment 1 ~ 3 group uses the embodiment of the present invention 1 ~ 3 gained plaster to prevent and treat respectively, and night every day, application was once in sheep lip; Matched group does not use any medicine, after being used in conjunction 10 days, gets the pathological material of disease suspension of goat, and to sheep mucosa scratch inoculation in sheep lip of embodiment group 1, embodiment group 2, embodiment group 3 and matched group, observed and recorded respectively organizes the sickness rate of sheep, and result is as shown in table 2.
Table 2 preventive effect statistical data
| Grouping | Embodiment 1 | Embodiment 2 | Embodiment 3 | Matched group |
| Sum | 50 | 50 | 50 | 50 |
| Infect number | 1 | 2 | 3 | 48 |
| Sickness rate | 2％ | 4％ | 6％ | 96％ |
| Protective rate | 98％ | 96％ | 94％ | 4％ |
Data from table 2: Chinese medicine composition of the present invention has obvious preventive effect to sheep stomatitis.
Claims (6)
1. prevent and treat a preparation method for lamb stomatitis plaster, it is characterized in that comprising the following steps:
1) 1 ~ 3g Mentholum is dissolved in 25 ~ 75ml iodine tincture, obtains iodine tincture Mentholum solution;
2) measure the iodine tincture Mentholum solution that the glycerol of 25 ~ 75ml and step (1) make to mix, obtain mixed solution;
3) take 1 ~ 3g xanthan gum to be dissolved in 25 ~ 75ml water, fully dissolve, obtain jelly;
4) step (2) is obtained mixed solution fully to mix with the jelly that (3) step is made, to obtain final product.
2. a kind of preparation method of preventing and treating lamb stomatitis plaster according to claim 1, is characterized in that comprising the following steps:
1) 2g Mentholum being dissolved in 50ml concentration is in the iodine tincture of 2%, obtains iodine tincture Mentholum solution;
2) measure the iodine tincture Mentholum solution that the glycerol of 50ml and step (1) make to mix, obtain mixed solution;
3) take 2g xanthan gum to be dissolved in 50ml water, fully dissolve, obtain jelly;
4) step (2) is obtained mixed solution fully to mix with the jelly that (3) step is made, to obtain final product.
3. preparation method according to claim 1 and 2, is characterized in that: in described iodine tincture, the mass concentration of iodine is 20g/L.
4. the plaster that obtains of preparation method according to claim 1 and 2.
5. the application of plaster according to claim 4 in control lamb stomatitis.
6. application according to claim 5, is characterized in that: described lamb is to the lamb in 60 ages in days after birth.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510320474.9A CN104906131B (en) | 2015-06-11 | 2015-06-11 | A kind of preparation method preventing and treating lamb stomatitis plaster |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510320474.9A CN104906131B (en) | 2015-06-11 | 2015-06-11 | A kind of preparation method preventing and treating lamb stomatitis plaster |
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| Publication Number | Publication Date |
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| CN104906131A true CN104906131A (en) | 2015-09-16 |
| CN104906131B CN104906131B (en) | 2018-11-16 |
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| CN201510320474.9A Expired - Fee Related CN104906131B (en) | 2015-06-11 | 2015-06-11 | A kind of preparation method preventing and treating lamb stomatitis plaster |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109793838A (en) * | 2019-02-22 | 2019-05-24 | 青岛农业大学 | A kind of plaster and preparation method thereof for preventing and treating chiru sheep mouth inflammation |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103536680A (en) * | 2013-09-27 | 2014-01-29 | 李文军 | Preparation for treating periodontosis |
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2015
- 2015-06-11 CN CN201510320474.9A patent/CN104906131B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103536680A (en) * | 2013-09-27 | 2014-01-29 | 李文军 | Preparation for treating periodontosis |
Non-Patent Citations (3)
| Title |
|---|
| 张守印: "羊口炎症状及防治", 《吉林农村报》 * |
| 肖晓薇: "羊口炎的预防与治疗", 《当代畜禽养殖业》 * |
| 薛艳丽: "复方薄荷脑碘滴鼻液的制备及质量控制", 《中国医院药学杂志》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109793838A (en) * | 2019-02-22 | 2019-05-24 | 青岛农业大学 | A kind of plaster and preparation method thereof for preventing and treating chiru sheep mouth inflammation |
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| CN104906131B (en) | 2018-11-16 |
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