CN104906051A - Nutrient granules and preparation method thereof - Google Patents
Nutrient granules and preparation method thereof Download PDFInfo
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- CN104906051A CN104906051A CN201510377347.2A CN201510377347A CN104906051A CN 104906051 A CN104906051 A CN 104906051A CN 201510377347 A CN201510377347 A CN 201510377347A CN 104906051 A CN104906051 A CN 104906051A
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- granular
- nutritional granular
- isoleucine
- leucine
- valine
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Abstract
The invention is applicable to the field of sport nutrition and pharmacy, and provides nutrient granules which comprise at least one of leucine, isoleucine and valine, and an adhesive, wherein the adhesive accounts for 0.1-5% of the nutrient granules in percentage by mass, and the bulk density of the nutrient granules is greater than 0.55g/L. The invention further provides a preparation method of the nutrient granules. The nutrient granules provided by the technical scheme are relatively high in bulk density and relatively good in flowability, and can be directly compressed or filled into capsules, and thus the dose can be reduced.
Description
Technical field
The invention belongs to sport nutrition, pharmaceutical field, be specifically related to a kind of nutritional granular and preparation method thereof.
Background technology
Granule containing leucine, isoleucine and valine is a kind of supplementary applying to move.This three seed amino acids bulk density size is about 0.36g/ml, not soluble in water, and has very strong bitterness and peculiar aminoacid abnormal smells from the patient.User's daily requirement amount is 5-10g/ time, and dose is very large.
If drink after water-soluble for the granule containing leucine, isoleucine and valine, because its hydrophobic guanidine radicals exists, its dissolution velocity is very slow, dissolves 5g powder completely in water, need be immersed in the water of about 500ml, and continuous stirring 2-3 hour.If make capsule by containing the granule of leucine, isoleucine and valine, need maximum number No. 000 capsule fill be used, often secondaryly eat more than 10.But as made the granule that bulk density is more than 0.55g/ml, with maximum number No. 000 capsule fill, be less than 7 capsules as long as eat at every turn.As being pressed into tablet, using conventional method tabletting, due to its poor compressibility, adding poor fluidity, the method for unavailable dry-pressing.As granulated with conventional wet lay, need add a large amount of adjuvant, what increase pressure rear panel amount takes number.
Therefore, take for convenience, need to allow its rapid solution, or make plastic capsule, or be pressed into tablet.After making tablet or capsule, not increasing taking of other adjuvant, when preparing granule, increasing its bulk density, reduced volume, the mobility that increases, minimizing granulation supplementary product consumption etc. are the problems that production capsule or tablet need solve.
Therefore, be necessary to provide a kind of nutritional granular and preparation method thereof, larger bulk density and mobility can be had, can be used in direct compression or encapsulating capsule.
Summary of the invention
Technical problem to be solved by this invention is the defect overcoming prior art, provides a kind of nutritional granular and preparation method thereof, can have larger bulk density and mobility, can be used in direct compression or encapsulating capsule.
The present invention realizes like this, a kind of nutritional granular, it comprises at least one in leucine, isoleucine and valine and binding agent, and the mass percent shared in described nutritional granular of described binding agent is 0.1-5%, and the bulk density of described nutritional granular is greater than 0.55g/L.
A preparation method for nutritional granular, comprises step:
Prepare binder solution;
Described binder solution is added in the powder of at least one in leucine, isoleucine and valine, granulates and obtain wet granular; And
Obtained described wet grain drying is obtained nutritional granular.
Nutritional granular that the technical program provides and preparation method thereof, described nutritional granular has larger bulk density and good mobility.Because the bulk density of described nutritional granular is high, effectively can reduce unit volume, be beneficial to encapsulating capsule.Further, the good fluidity of described nutritional granular, may be used for dry-pressing and becomes tablet, does not need to add fluidizer and lubricant.Therefore, the nutritional granular adopting the technical program to provide, effectively can reduce and take number, facilitate user to take.Further, conventional method is for the preparation of the granule of tabletting, and at least need to add the multiple auxiliary materials such as binding agent, fluidizer, disintegrating agent, the nutritional granular that the technical program provides only need add binding agent, and the consumption of binding agent is less.Compared with the supplementary product consumption 20% preparing granule with the art, preparing nutritional granular and the consumption of adjuvant binding agent can be reduced to less than 5% prepared by the present invention.
Accompanying drawing explanation
Fig. 1 is the flow chart of the preparation method of the nutritional granular that the embodiment of the present invention provides;
Detailed description of the invention
In order to make object of the present invention, technical scheme and advantage clearly understand, below in conjunction with drawings and Examples, the present invention is further elaborated.Should be appreciated that specific embodiment described herein only in order to explain the present invention, be not intended to limit the present invention.
First embodiment of the invention provides a kind of nutritional granular, it comprises at least one in leucine, isoleucine and valine and binding agent, the mass percent of described binding agent shared by described nutritional granular is 0.1-5%, and the bulk density of described nutritional granular is greater than 0.55g/L.
The particle diameter of described nutritional granular is 20 microns to 850 microns.Described binding agent is selected from least one in modified starch, xanthan gum, carrageenan, hydroxypropyl emthylcellulose (HPMC), arabic gum, dextrin, polyvinyl alcohol etc.Described nutritional granular can adopt one or both methods such as dry granulation method, extrusion spheronization method for making, fluidized bed granulation method, either spray granulation, high shear granulation to prepare.Describedly can to mix according to arbitrary proportion to leucine, isoleucine and valine, namely described nutrition can comprise to the one in leucine, isoleucine and valine, two kinds or three kinds.As described in leucine, isoleucine and valine mass ratio 2:1:1.
Refer to Fig. 1, the technical program second embodiment provides a kind of preparation method of described nutritional granular, and the preparation method of described nutritional granular comprises step:
S101, prepares binder solution.
Described binding agent can be at least one in modified starch, xanthan gum, carrageenan, hydroxypropyl emthylcellulose (HPMC), arabic gum, dextrin, polyvinyl alcohol etc., described binding agent is made into 0.5%-10% solution, for subsequent use.
S102, is added in the powder of at least one in leucine, isoleucine and valine by described binder solution, granulate and obtain wet granular.
Be understandable that, when to be only in leucine, isoleucine and valine a kind of for the raw material adopted, can described raw material directly poured in granulation pot, by binder solution, spray in proportion in granulation pot, wet granular of granulating to obtain.The mass percent of described binding agent shared by described nutritional granular is 0.1-5%.
When the raw material adopted to comprise in leucine, isoleucine and valine two kinds or two or more time, ratio as required first material powder can be poured in granulation pot, as leucine, isoleucine and valine powder are weighed in 2:1:1 ratio, pour in granulation pot, start mix homogeneously, take suitable amount of adhesive solution, spray in proportion in granulation pot, wet granular of granulating to obtain.The mass percent of described binding agent shared by described nutritional granular is 0.1-5%.
S103, obtains nutritional granular by obtained described wet grain drying.
Described wet granular can carry out drying by the mode such as vacuum drying or microwave drying and obtain nutritional granular.
Described nutritional granular can adopt one or both methods such as dry granulation method, extrusion spheronization method for making, fluidized bed granulation method, either spray granulation, high shear granulation to prepare.
Nutritional granular that the technical program provides and preparation method thereof, described nutritional granular has larger bulk density and good mobility.Because the bulk density of described nutritional granular is high, effectively can reduce unit volume, be beneficial to encapsulating capsule.Further, the good fluidity of described nutritional granular, may be used for dry-pressing and becomes tablet, does not need to inject fluidizer and lubricant.Therefore, the nutritional granular adopting the technical program to provide, effectively can reduce and take number, facilitate user to take.And, conventional method is for the preparation of the granule of tabletting, at least need to add the multiple auxiliary materials such as binding agent, fluidizer, disintegrating agent, the nutritional granular that the technical program provides only need add binding agent, and the consumption of binding agent is less, the supplementary product consumption general compared with this area is 20%, and the consumption of adjuvant binding agent can be reduced to less than 5% by the nutritional granular that the technical program provides.
Below, the preparation method of the nutritional granular that the technical program provides is described with specific embodiment:
Embodiment 1
First binding agent is dissolved, be made into 0.5%-10% solution, for subsequent use.
Then leucine, isoleucine and valine powder are weighed in 2:1:1 ratio, pour in granulation pot, start mix homogeneously, takes suitable amount of adhesive solution, sprays in proportion in granulation pot, wet granular of granulating to obtain.
Wet granular is by vacuum drying or microwave drying, and obtain dry granule, dry granule can be directly used in tabletting or encapsulating capsule.
Embodiment 2
First binding agent is dissolved, be made into 0.5%-10% solution, for subsequent use.
To weigh leucine powder, poured in granulation pot, start mix homogeneously, takes suitable amount of adhesive solution, sprays in proportion in granulation pot, wet granular of granulating to obtain.
Wet granular is by vacuum drying or microwave drying, and obtain dry granule, dry granule can be directly used in tabletting or encapsulating capsule.
Embodiment 3
First binding agent is dissolved, be made into 0.5%-10% solution, for subsequent use.
To weigh isoleucine powder, poured in granulation pot, start mix homogeneously, takes suitable amount of adhesive solution, sprays in proportion in granulation pot, wet granular of granulating to obtain.
Wet granular is by vacuum drying or microwave drying, and obtain dry granule, dry granule can be directly used in tabletting or encapsulating capsule.
Embodiment 4
First binding agent is dissolved, be made into 0.5%-10% solution, for subsequent use.
To weigh valine powder, poured in granulation pot, start mix homogeneously, takes suitable amount of adhesive solution, sprays in proportion in granulation pot, wet granular of granulating to obtain.
Wet granular is by vacuum drying or microwave drying, and obtain dry granule, dry granule can be directly used in tabletting or encapsulating capsule.
Embodiment 5
First binding agent is dissolved, be made into 0.1%-5% solution, for subsequent use.
Then leucine, isoleucine and valine powder are weighed in 2:1:1 (or 2:1:0 or 0:1:1 or 2:0:1 or 1:0:0 or 0:1:0 or 0:0:1) ratio, pour in fluid bed, start, take suitable amount of adhesive solution, sprinkling powder surface in proportion, wet granular of granulating to obtain.
Wet granular is by vacuum drying or microwave drying, and obtain dry granule, dry granule can be directly used in tabletting or encapsulating capsule.
Embodiment 6
First binding agent is dissolved, be made into 0.1%-5% solution, for subsequent use.
Then leucine, isoleucine and valine powder are weighed in 2:1:1 (or 2:1:0 or 0:1:1 or 2:0:1 or 1:0:0 or 0:1:0 or 0:0:1) ratio; pour in wet mixing blender; take a certain amount of binding agent to add; mix homogeneously; be put in extrusion granulator machine, carry out extrusion granulator, wet granular is by hot blast rotary furnace drying; obtain dry granule, dry granule can be directly used in tabletting or encapsulating capsule.
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, all any amendments done within the spirit and principles in the present invention, equivalent replacement and improvement etc., all should be included within protection scope of the present invention.
Claims (10)
1. a nutritional granular, it comprises at least one in leucine, isoleucine and valine and binding agent, and the mass percent shared in described nutritional granular of described binding agent is 0.1-5%, and the bulk density of described nutritional granular is greater than 0.55g/L.
2. nutritional granular as claimed in claim 1, it is characterized in that, described binding agent is selected from least one in modified starch, xanthan gum, carrageenan, hydroxypropyl emthylcellulose, arabic gum, dextrin, polyvinyl alcohol.
3. nutritional granular as claimed in claim 1, it is characterized in that, the particle diameter of described nutritional granular is 20 microns to 850 microns.
4. nutritional granular as claimed in claim 1, is characterized in that, described nutritional granular adopts one or both methods in dry granulation method, extrusion spheronization method for making, fluidized bed granulation method, either spray granulation and high shear granulation to prepare.
5. nutritional granular as claimed in claim 1, it is characterized in that, described leucine, isoleucine and valine mass ratio 2:1:1, or described nutritional granular comprises two kinds in leucine, isoleucine and valine, and mass ratio is 2:1 or 1:1, or described nutritional granular only comprises the one in leucine, isoleucine and valine.
6. a preparation method for nutritional granular, comprises step:
Prepare binder solution;
Described binder solution is added in the powder of at least one in leucine, isoleucine and valine, granulates and obtain wet granular; And
Obtained described wet grain drying is obtained nutritional granular.
7. the preparation method of nutritional granular as claimed in claim 6, it is characterized in that, described binding agent is at least one in modified starch, xanthan gum, carrageenan, hydroxypropyl emthylcellulose, arabic gum, dextrin, polyvinyl alcohol, and described binding agent is made into 0.5%-10% solution.
8. the preparation method of nutritional granular as claimed in claim 6, it is characterized in that, when to be only in leucine, isoleucine and valine a kind of for the raw material adopted, described raw material is directly poured in granulation pot, described binder solution is sprayed in described granulation pot, wet granular of granulating to obtain; When the raw material adopted to comprise in leucine, isoleucine and valine two kinds or two or more time, material powder is poured in granulation pot by ratio as required, and start mix homogeneously, takes binder solution, spray in granulation pot, wet granular of granulating to obtain.
9. the preparation method of nutritional granular as claimed in claim 8, is characterized in that, leucine, isoleucine and valine powder are weighed in 2:1:1 ratio, pour in granulation pot, start mix homogeneously, takes binder solution, spray in granulation pot, wet granular of granulating to obtain.
10. the preparation method of nutritional granular as claimed in claim 6, it is characterized in that, described wet granular carries out drying by vacuum drying or microwave drying mode and obtains nutritional granular.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201510377347.2A CN104906051A (en) | 2015-07-01 | 2015-07-01 | Nutrient granules and preparation method thereof |
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| CN201510377347.2A CN104906051A (en) | 2015-07-01 | 2015-07-01 | Nutrient granules and preparation method thereof |
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| CN104906051A true CN104906051A (en) | 2015-09-16 |
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| CN201510377347.2A Pending CN104906051A (en) | 2015-07-01 | 2015-07-01 | Nutrient granules and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105747214A (en) * | 2016-02-26 | 2016-07-13 | 四川安益生物科技有限公司 | Branched-chain amino acid composition |
| CN109662947A (en) * | 2018-12-16 | 2019-04-23 | 新疆阜丰生物科技有限公司 | A kind of technique preparing BCAA particle |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1248885A (en) * | 1997-02-25 | 2000-03-29 | 底古萨－胡尔斯股份公司 | Method for preparing pourable methionine salt based animal food supplement and the granulate thus obtained |
| CN1449253A (en) * | 2000-08-04 | 2003-10-15 | 阿迪索法国两合公司 | Process for the preparation of granules of methionine |
| CN1658862A (en) * | 2002-01-24 | 2005-08-24 | 味之素株式会社 | Process for producing granules containing branched amino acids |
| CN102960546A (en) * | 2012-12-03 | 2013-03-13 | 华中药业股份有限公司 | Compound amino acid particle and preparation method thereof |
-
2015
- 2015-07-01 CN CN201510377347.2A patent/CN104906051A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1248885A (en) * | 1997-02-25 | 2000-03-29 | 底古萨－胡尔斯股份公司 | Method for preparing pourable methionine salt based animal food supplement and the granulate thus obtained |
| CN1449253A (en) * | 2000-08-04 | 2003-10-15 | 阿迪索法国两合公司 | Process for the preparation of granules of methionine |
| CN1658862A (en) * | 2002-01-24 | 2005-08-24 | 味之素株式会社 | Process for producing granules containing branched amino acids |
| CN102960546A (en) * | 2012-12-03 | 2013-03-13 | 华中药业股份有限公司 | Compound amino acid particle and preparation method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105747214A (en) * | 2016-02-26 | 2016-07-13 | 四川安益生物科技有限公司 | Branched-chain amino acid composition |
| CN109662947A (en) * | 2018-12-16 | 2019-04-23 | 新疆阜丰生物科技有限公司 | A kind of technique preparing BCAA particle |
| CN109662947B (en) * | 2018-12-16 | 2021-09-10 | 新疆阜丰生物科技有限公司 | Process for preparing BCAA granules |
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| CB03 | Change of inventor or designer information |
Inventor after: Jiang Jianghong Inventor after: Zhang Xiaoyou Inventor before: Jiang Jianghong Inventor before: Zhang Xiaoquan |
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Application publication date: 20150916 |