CN104897611A - Biochemical analyzer based on optofuidic sensor with inner cavity structure - Google Patents
Biochemical analyzer based on optofuidic sensor with inner cavity structure Download PDFInfo
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- CN104897611A CN104897611A CN201410175394.4A CN201410175394A CN104897611A CN 104897611 A CN104897611 A CN 104897611A CN 201410175394 A CN201410175394 A CN 201410175394A CN 104897611 A CN104897611 A CN 104897611A
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Abstract
The invention relates to the field of optical detection, especially to a biochemical analyzer based on an optofuidic sensor with an inner cavity structure. The biochemical analyzer comprises a sample cell, the optofuidic sensor, a waste liquid pool and pipelines and is characterized in that the optofuidic sensor is provided with a cavity; the cavity is communicated with the sample cell and the waste liquid pool through the pipelines; a liquid level height difference exists at one side of the optofuidic sensor or between two sides of the optofuidic sensor; and the liquid level pressure difference drives a sample in the sample cell to flow through the optofuidic sensor to the waste liquid pool via the pipelines. The biochemical analyzer provided by the invention has the characteristics of simple testing, short testing time and high detection precision.
Description
Technical field
The present invention relates to field of optical detection, particularly a kind of Biochemical Analyzer based on inner-cavity structure optofluidic sensor.
Background technology
The fusion of optical detective technology and microfluidic chip technology, has expedited the emergence of " optofluidic " sensor.Utilize optofluidic sensor to carry out analysis to liquid or gaseous sample to detect, there is high sensitivity, in real time dynamically and the advantage of micro-example demand.At present, based on optofluidic sensor and the tintmeter of optical detecting method, be commonly used to the refractive index and absorbance that detect sample.And, based on the optofluidic sensor industrialization of surface plasmon resonance effect (SPR).But, the complex structure of SPR detector, the expensive raising (detection limit is about 10-6 refractive index unit) and accuracy of detection needs.And usually adopt mechanical pump to drive sample flow at present, mechanical vibration can make sample flow rate unstable, affect measuring accuracy.
Meanwhile, for tintmeter, then needing testing sample and standard model to be placed in different cuvettes respectively, carrying out contrast test by changing cuvette.Therefore, usually need to change cuvette back and forth, which increase the test duration, affect measuring accuracy, and the volume of cuvette sample size that is comparatively large, that need is also more.Therefore the new method of testing of design research and development, thus simplify test macro, improve the stability of sample flow, reduce the test duration and improve accuracy of detection, be motivation of the present invention.
Summary of the invention
The object of the invention is to overcome above-described shortcoming, provide and possess low cost, compact conformation, easy to use, and the feature that the test duration is short, accuracy of detection is high.
For achieving the above object, concrete scheme of the present invention is as follows:
A kind of Biochemical Analyzer based on inner-cavity structure optofluidic sensor, comprise: sample cell, optofluidic sensor, waste liquid pool and pipeline, it is characterized in that: in described optofluidic sensor, be provided with cavity, described cavity is communicated with described waste liquid pool with described sample cell by described pipeline, have liquid level difference in the side of described optofluidic sensor or between the both sides of described optofluidic sensor, the pressure differential that described liquid level difference produces drives the sample in described sample cell flow through described optofluidic sensor by described pipeline and flow to described waste liquid pool.
Wherein, described liquid level difference is the difference in height between the liquid level place plane of liquid in the liquid level place plane of liquid in described sample cell and described waste liquid pool.
Wherein, also comprise Buffer Pool, described Buffer Pool is sealing, described Buffer Pool is communicated with described waste liquid pool with described optofluidic sensor by described pipeline, and described liquid level difference is the difference in height in described Buffer Pool in liquid levels place plane and described waste liquid pool between the plane of liquid levels place.
Wherein, described sample cell is what seal, and described sample cell is provided with the valve with air circulation.
Wherein, described sample cell is by piston seal, and described piston moves up or down according to the pressure change in described sample cell or described waste liquid pool.
Wherein, described sample cell is telescopic airbag.
Wherein, the scope of described liquid level difference is 0.2cm-200cm.
Wherein, the volume of described sample cell and described Buffer Pool and described waste liquid pool is greater than or equal to 1,000 times of described cavity volume.
Wherein, the number of described sample cell is at least 2, described sample cell is connected with the branch road be connected with described pipeline.
Wherein, convergence place of described branch road and described pipeline is provided with the multiway valve such as threeway, four-way.
Wherein, described pipeline and/or described branch road are provided with flow control valve, the speed of described Flux Valve Control sample flow.
Wherein, described optofluidic sensor comprises: cap rock, substrate and the interlayer between cap rock and substrate, described cavity is located in described interlayer.
Wherein, be provided with optical medium film between described cap rock and described interlayer and/or be provided with optical medium film between described interlayer and described substrate.
The invention has the beneficial effects as follows: first, structure of the present invention is simple, compact, easy to use; Secondly, the present invention is by regulating the liquid level between sample cell and waste liquid pool poor, or by regulating the liquid level between Buffer Pool and waste liquid pool poor, make sample with stable flow velocity by described optofluidic sensor, effectively eliminate the measuring error because flow velocity instability causes, improve measuring accuracy; Again, the multiple sample cell connecting pipe of employing of the present invention, and valve can be utilized directly to switch the sample of flow sensor, save the test duration.
Accompanying drawing explanation
Fig. 1 is the Biochemical Analyzer structural representation of tracer liquid sample
Fig. 2 is the fundamental diagram of the Biochemical Analyzer of tracer liquid sample
Fig. 3 is the Biochemical Analyzer structural representation detecting gaseous sample
Fig. 4 is the fundamental diagram of the Biochemical Analyzer detecting gaseous sample
Fig. 5 is the fundamental diagram of the Biochemical Analyzer by piston seal sample cell
Fig. 6 has the optofluidic sensor construction schematic diagram of inner-cavity structure
Fig. 7 has the optofluidic sensor construction schematic diagram of rhythmo structure
Fig. 8 has the resonator cavity optofluidic sensor construction schematic diagram of rhythmo structure
Description of reference numerals in Fig. 1 to Fig. 8: 1-sample cell, 2-optofluidic sensor, 21-cavity, 22-cap rock, 23-substrate, 24-interlayer, 25-optical medium film, 3-waste liquid pool, 4-pipeline, 5-flow control valve, 6-Buffer Pool, 7-valve, 8-multiway valve, 9-piston.
Embodiment
Below in conjunction with the drawings and specific embodiments, the present invention is further detailed explanation, is not practical range of the present invention is confined to this.
Adopt Biochemical Analyzer structure as shown in Figure 1, for tracer liquid sample refractive index and absorbance.Comprise: sample cell 1, optofluidic sensor 2, waste liquid pool 3 and pipeline 4, cavity 21 is provided with in described optofluidic sensor 2, described cavity 21 is communicated with described waste liquid pool 3 with described sample cell 1 by described pipeline 4, described sample cell 1 is at least 2, is respectively used to load bearing fluid standard model and testing sample.Described sample cell 1 is connected with the branch road be communicated with described pipeline 4, and wherein, described pipeline 4 and/or described branch road are provided with flow control valve 5, the speed of described flow control valve 5 Quality control flowing.Preferably, convergence place of described branch road and described pipeline 4 is provided with the multiway valve such as threeway, four-way.
In described sample cell 1, testing sample and standard model are housed respectively.Described sample cell 1 and described waste liquid pool 3 lay respectively at the both sides of described optofluidic sensor 2, and in the plane at liquid levels place in described sample cell 1 and described waste liquid pool 3 liquid levels place plane between have liquid level difference Δ H, due to syphonic effect, the pressure differential that described liquid level difference Δ H produces drives the sample in described sample cell 1 to flow through the cavity 21 of described optofluidic sensor 2 by described pipeline 4, and flows in described waste liquid 3.
Wherein, the scope of described liquid level difference Δ H is 0.2cm-200cm, and the liquid level difference Δ H in the present embodiment is 10cm.The volume of described sample cell 1 and described waste liquid pool 3 is greater than or equal to 1,000 times of described cavity volume 21, cavity 21 volume due to described optofluidic sensor 2 in the present embodiment very little (magnitude of about 1 microlitre), the flowing speed of sample is very low (about 0.1 milliliter of magnitude per minute).Therefore, if the sample cell selecting volume larger and waste liquid pool (being greater than 10 milliliters), and each test duration only needs a few minutes, within the test duration, the change of liquid level difference Δ H is very little, thus the stable of sample flow rate can be kept, and, by changing size or the adjust flux variable valve 5 of liquid level difference Δ H or pipeline 4, the flow velocity of sample can be regulated, make the circulation that sample is mild.Along with the flowing of sample, described liquid level difference Δ H is linear slowly reduction, and compared with the random noise caused with mechanical vibration, the signal drift that the linear change of this liquid level difference Δ H causes is easier to process and eliminates.
As shown in Fig. 2 liquid detecting fundamental diagram, in testing process, regulate multiway valve 8, under liquid level difference Δ H between described sample cell 1 and described waste liquid pool 3 drives, standard model in sample cell 1 is circulated and imports to the cavity 21 of described optofluidic sensor 2, and flow in described waste liquid pool 3.The flow control valve 5 of regulable control standard model, the speed of adjustment criteria sample flow, makes fluid sample slowly circulate stably.After incident illumination is mapped to described optofluidic sensor 2, the intensity of transmitted light and phase place then the absorbance of, sample long with chamber and sample refractive index relevant; Therefore, incident light is through after the cavity 21 containing fluid sample, and the transmitted light that formation and before incident light phase place and light intensity there are differences, described transmitted light converges in photodetector, and records the light intensity after converging and phase place.Regulate multiway valve 8 again, testing sample is circulated and imports the described cavity 21 to optofluidic sensor 2, and flow in described waste liquid pool 3.The flow control valve 5 of regulable control testing sample, regulate the speed of testing sample circulation, testing sample is slowly circulated stably, incident light is through described optofluidic sensor 2, and converge in photodetector, transmitted light through standard model and testing sample is carried out to the comparative analysis of light intensity and light phase, draw the characteristic such as refractive index and absorbance of testing sample.Preferably, described incident light before entering described optofluidic sensor 2, through the parallel processing of optical fiber collimator or optical lens, same, described transmitted light enters in described photodetector after optical lens convergence processing, thus further optimum detection result, improve accuracy of detection.
Biochemical Analyzer as shown in Figure 3, for detecting gaseous sample refractive index and absorbance.Comprise sample cell 1, optofluidic sensor 2, waste liquid pool 3, Buffer Pool 6 and pipeline 4.Be provided with cavity 21 in described optofluidic sensor 2, described cavity 21 is communicated with described Buffer Pool 6 and described waste liquid pool 3 with described sample cell 1 by described pipeline 4, and described sample cell 1 is at least 2, is respectively used to carrying Reference Material of Gases and testing sample.Described sample cell 1 is connected with the branch road be communicated with described pipeline 4, wherein, described pipeline 4 and/or described branch road are provided with flow control valve 5, the speed of described flow control valve 5 Quality control flowing, preferably, convergence place of described branch road and described pipeline 4 is provided with the multiway valve such as threeway, four-way.
Sample in described sample cell 1 is gaseous sample, and described sample cell 1 is closed type, and described sample cell 1 is provided with the valve 7 controlled with air circulation.Described sample cell 1 is in the side of described optofluidic sensor 2, and described Buffer Pool 6 and described waste liquid pool 3 are at the opposite side of described optofluidic sensor 2.Described Buffer Pool 6 is hermetic type, described Buffer Pool 6 one end is communicated with described optofluidic sensor, the other end is communicated with described waste liquid pool 3, there is liquid level difference Δ H in described Buffer Pool 6 in the plane at the liquid level place of liquid and described waste liquid pool 3 between the plane of liquid levels place.Due to syphonic effect, liquid in Buffer Pool 6 described in the pressure-driven that described liquid level difference Δ H produces enters into described waste liquid pool 3, the pressure in described Buffer Pool 6 is made to reduce thus, drive the gaseous sample in described sample cell 1 to flow through described optofluidic sensor 2, and enter in described Buffer Pool 6.Because described sample cell 1 is provided with the valve 7 with air circulation, when opening valve 7, the air pressure in described sample cell keeps identical with ambient pressure all the time, can ensure that gaseous sample continues to circulate in described optofluidic sensor.Preferably, described sample cell 1 is telescopic airbag, and described airbag according to the pressure change expansion of gas in described airbag or can shrink, thus ensures that in described airbag, pressure is constant.Preferably, described sample cell 1 is by piston seal, and described piston moves up or down according to the pressure change in described sample cell 1, keeps the pressure identical with the external world.
Wherein, the scope of described liquid level difference Δ H is 0.2cm-200cm, and the liquid level difference Δ H in the present embodiment is 10cm.The volume of described Buffer Pool 6 and described waste liquid pool 3 is greater than or equal to 1,000 times of described cavity volume, cavity 21 volume due to described optofluidic sensor 2 in the present embodiment very little (magnitude of about 1 microlitre), the flow rate of sample can very low (about 0.1 milliliter of magnitude per minute).Therefore, if the Buffer Pool selecting volume larger and waste liquid pool (being greater than 10 milliliters), and each test duration only need a few minutes, within the test duration, the change of liquid level difference Δ H is very little, thus can keep the stable of sample flow rate.And by changing size or the flow control valve 5 of described liquid level difference Δ H or pipeline 4, can regulate the flow velocity of sample, along with the flowing of sample, liquid level difference Δ H linearly reduces slowly.Compared with the random noise caused with mechanical vibration, the signal drift that the linear change of this liquid level difference Δ H causes is easier to process and eliminates.
As shown in Fig. 4 gas detect fundamental diagram, in testing process, regulate multiway valve 8, under the liquid level difference Δ H between described Buffer Pool 6 and described waste liquid pool 3 drives, standard model is circulated import in the cavity 21 of described optofluidic sensor 2, and flow in described Buffer Pool 6.Regulate the flow control valve 5 of described control criterion sample, regulate the speed of sample flow, fluid sample is slowly circulated stably.When incident illumination is mapped to described optofluidic sensor 2, the intensity of transmitted light and phase place then the absorbance of, gaseous sample long with chamber and gaseous sample refractive index relevant, therefore, incident light is through after the cavity 21 containing gaseous sample, the transmitted light that formation and before incident light phase place and light intensity there are differences, described transmitted light converges in photodetector.Regulate multiway valve 8, testing sample is circulated in the cavity 21 of optofluidic sensor 2 described in importing, and flows in described Buffer Pool 6.Regulate the flow control valve 5 of described control testing sample, regulate the speed of sample flow, gaseous sample is slowly circulated stably, incident light is through described optofluidic sensor 2, and converge in photodetector, to the transmitted light through standard model and testing sample, carry out the comparative analysis of light intensity and light phase, draw the characteristic such as refractive index and absorbance of testing sample.Preferably, described incident light before entering described optofluidic sensor 2, through the parallel processing of optical fiber collimator or optical lens, same, described transmitted light enters in described photodetector after optical lens convergence processing, thus further optimum detection result, improve accuracy of detection.
For in above-mentioned 2 embodiments, as shown in Figure 6, described optofluidic sensor 2 comprises: cap rock 22 and substrate 23, and described cap rock 22, by corrosion or imprint process, substrate prepares cavity structure; Described substrate 23 is bonded together with described cap rock 22, forms the optofluidic sensor 2 with inner-cavity structure.
Preferably, as shown in Figure 7, described optofluidic sensor 2 adopts rhythmo structure, and described rhythmo structure comprises: cap rock 22, substrate 23 and the interlayer between cap rock and substrate 24, and described cavity 21 to be arranged on described interlayer and to be bonded together with described cap rock 22 and described substrate 23.
Preferably, as shown in Figure 8, on described cap rock 22 and/or described substrate 24, optical medium film 25 is coated with, as Si/SiO
2, thus form the inner-cavity structure optofluidic sensor 2 with optical resonance effect.
Described cap rock 22 in described optofluidic sensor 2, substrate 23, interlayer 24 adopt the translucent materials such as glass material, organic material or crystalline material.
In sum, a kind of Biochemical Analyzer based on inner-cavity structure optofluidic sensor provided by the invention, by adopting the type of drive of liquid level difference to drive sample flow, making liquid keep slowly flow velocity stably, improving from measuring accuracy; Meanwhile, adopt switching and the flow velocity of flow control valve Quality control, save detection time, it also avoid the error changed sample cell and produce, improve measuring accuracy further.
The above is only two preferred embodiments of the present invention, therefore all equivalences done according to structure, feature and the principle described in patent claim of the present invention change or modify, and are included in the protection domain of patented claim of the present invention.
Claims (13)
1. the Biochemical Analyzer based on inner-cavity structure optofluidic sensor, comprise: sample cell, optofluidic sensor, waste liquid pool and pipeline, it is characterized in that: in described optofluidic sensor, be provided with cavity, described cavity is communicated with described waste liquid pool with described sample cell by described pipeline, liquid level difference is had in the side of described optofluidic sensor or between the both sides of described optofluidic sensor, the pressure differential that described liquid level difference produces drives the sample in described sample cell flow through described optofluidic sensor by described pipeline and flow to described waste liquid pool.
2. a kind of Biochemical Analyzer based on inner-cavity structure optofluidic sensor according to claim 1, is characterized in that: described liquid level difference is the difference in height between the liquid level place plane of liquid in the liquid level place plane of liquid in described sample cell and described waste liquid pool.
3. a kind of Biochemical Analyzer based on inner-cavity structure optofluidic sensor according to claim 1, it is characterized in that: also comprise Buffer Pool, described Buffer Pool is sealing, described Buffer Pool is communicated with described waste liquid pool with described optofluidic sensor by described pipeline, and described liquid level difference is the difference in height in described Buffer Pool in liquid levels place plane and described waste liquid pool between the plane of liquid levels place.
4. a kind of Biochemical Analyzer based on inner-cavity structure optofluidic sensor according to claim 3, is characterized in that: described sample cell is what seal, and described sample cell is provided with the valve with air circulation.
5. a kind of Biochemical Analyzer based on inner-cavity structure optofluidic sensor according to claim 3, is characterized in that: described sample cell is by piston seal, and described piston moves up or down according to the pressure change in described sample cell or described waste liquid pool.
6. a kind of Biochemical Analyzer based on inner-cavity structure optofluidic sensor according to claim 3, is characterized in that: described sample cell is telescopic airbag.
7. a kind of Biochemical Analyzer based on inner-cavity structure optofluidic sensor according to claim 1,2,3,4,5 or 6, is characterized in that: the scope of described liquid level difference is 0.2cm-200cm.
8. a kind of Biochemical Analyzer based on inner-cavity structure optofluidic sensor according to claim 1,2,3,4,5 or 6, is characterized in that: the volume of described sample cell and described Buffer Pool and described waste liquid pool is greater than or equal to 1,000 times of described cavity volume.
9. a kind of Biochemical Analyzer based on inner-cavity structure optofluidic sensor according to claim 1, is characterized in that: the number of described sample cell is at least 2, described sample cell is connected with the branch road be connected with described pipeline.
10. a kind of Biochemical Analyzer based on inner-cavity structure optofluidic sensor according to claim 9, is characterized in that: convergence place of described branch road and described pipeline is provided with the multiway valve such as threeway, four-way.
11. a kind of Biochemical Analyzers based on inner-cavity structure optofluidic sensor according to claim 1,9 or 10, is characterized in that: described pipeline and/or described branch road are provided with flow control valve, the speed of described Flux Valve Control sample flow.
12. a kind of Biochemical Analyzers based on inner-cavity structure optofluidic sensor according to claim 1,2,3,4,5 or 6, it is characterized in that: described optofluidic sensor comprises: cap rock, substrate and the interlayer between cap rock and substrate, described cavity is located in described interlayer.
13. a kind of Biochemical Analyzers based on inner-cavity structure optofluidic sensor according to claim 12, is characterized in that: described cap rock and/or described substrate are coated with optical medium film.
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