CN104892969A - Composite chitosan and cellulose membrane and preparation method and application thereof - Google Patents
Composite chitosan and cellulose membrane and preparation method and application thereof Download PDFInfo
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Abstract
The invention discloses a composite chitosan and cellulose membrane. A preparation method of the composite chitosan and cellulose membrane includes the steps of 1), precooling a cellulose solvent, adding cellulose into the precooled cellulose solvent with stirring, dissolving to obtain a cellulose solution, subjecting the obtained cellulose solution to defoaming, edulcoration, tape casting and film scraping, coagulating in coagulating bath to shape and performing water scrubbing so as to obtain a regenerated cellulose membrane; 2), dissolving chitosan in a solvent to enable the chitosan to be distributed uniformly; 3), coating a solution obtained in the step 2 on the regenerated cellulose membrane by a needle head in an electrostatic spraying manner so as to obtain the composite chitosan and cellulose membrane. The preparation method is simple, low in cost and free from toxicity and pollution, and the prepared composite chitosan and cellulose membrane is high in biocompatibility and biodegradability, good in anti-infection performance and blood coagulation effect, capable of promoting wound healing and enhancing immunocompetence and easy in functionalized expanding of application fields and can be widely applied to the fields of biological medicine, food industry and the like.
Description
Technical field
The invention belongs to functional high molecule material technical field, be specifically related to a kind of chitin fiber element composite membrane and its preparation method and application.
Background technology
Along with increasingly sharpening of global problem of environmental pollution, take oil as the sharply consumption of the Nonrenewable resources of representative, the development and utilization of renewable resources causes the great attention of numerous scientific research person, becomes the mankind and seeks the new direction of of sustainable development path.Natural macromolecular material science new system based on renewable resources is formed.In recent years, membrane science and technology is fast-developing, adopts natural macromolecular material petroleum replacing Chemicals to prepare functional membrane material and causes great concern.Chitosan is natural high moleculer eompound (chitin removes the product of most of ethanoyl) the abundantest except Mierocrystalline cellulose on the earth; it is the same with Mierocrystalline cellulose has the advantages such as nontoxic pollution-free, renewable easy degraded and good biocompatibility; simultaneously it or a kind of natural antiseptic-germicide, therefore by the widespread use as a kind of new type natural biomaterial.But chitosan water-absorbent is strong, the easily swelling and poor mechanical property of the mould material prepared with it, is all subject to a definite limitation as separatory membrane or biological medicinal membrane.Mierocrystalline cellulose and chitosan are combined and can prepare the mould material simultaneously with cellulose membrane and chitosan film advantage, and the deficiency that cellulose membrane and chitosan film exist can be made up, make that the use range of mould material is wider, performance is more superior.The development & application of multifunction mould material is also an important trend of membrane science and technology development.
At present, the composite membrane prepared for raw material with Mierocrystalline cellulose and chitosan, Mierocrystalline cellulose and chitosan dissolve then to mix by common preparation method respectively, or first mix and dissolve afterwards.In institute's solvent system of dissolving cellulos and chitosan, such as trifluoroacetic acid, NaOH/ thiocarbamide and N-methacrylate moiety-N-oxide compound (NMMO) etc., all more or less there is deficiency or defect, as poisonous, volatile, preparation difficulty, the rate of recovery is low, solubility property is poor, feed degradation degree is large.And also also exist that consistency is bad based on the Cellulose/Chitosan composite membrane that these solvents are obtained, poor mechanical property or the shortcoming such as anti-microbial property is not remarkable.Novel cellulose/chitosan film material that one side has a germ resistance has great theoretical and practical significance equally to adopt brand-new, eco-friendly method to prepare.
Summary of the invention
Chitin fiber element composite membrane that the object of this invention is to provide a kind of one side and its preparation method and application, the preparation method related to operates facility, with low cost, nontoxic pollution-free, obtained chitin fiber element composite membrane has good biocompatibility and biodegradability, and very strong anti-infection property and Blood clotting, can wound healing be promoted, strengthen immunological competence.
For achieving the above object, the technical solution used in the present invention is: a kind of preparation method of chitin fiber element composite membrane, adopts quiet
Electrospray applies chitosan solution on cellulosic matrix mould material, specifically comprises the following steps:
1) cellosolve is chilled to-12 ~-5 DEG C in advance, adds Mierocrystalline cellulose stirring and dissolving and obtain cellulose solution, by curtain coating knifing after the deaeration of gained cellulose solution, removal of impurities, and in precipitation bath solidification forming, then wash, obtain regenerated cellulose film;
2) chitosan is dissolved in solvent under agitation, the chitosan solution that must mix;
3) using syringe needle as nozzle, adopt electrostatic spray mode that chitosan solution is coated on regenerated cellulose film surface, after washing described chitin fiber element composite membrane.
In such scheme, described cellosolve is sodium hydroxide/aqueous solution of urea; Precipitation bath is water or dilute acid solution.
In such scheme, in described cellosolve, the mass concentration of sodium hydroxide is 6 ~ 10%, the mass concentration of urea is 2 ~ 20%, all the other are water, and in cellulose solution, mass percent shared by Mierocrystalline cellulose is 0.5 ~ 15%.
In such scheme, step 2) described in solvent be acetic acid solution or sodium hydroxide/aqueous solution of urea; Wherein, in acetic acid solution, mass percent shared by acetic acid is 2 ~ 90%; In sodium hydroxide/aqueous solution of urea, mass percent shared by sodium hydroxide is 8 ~ 12%, and mass percent shared by urea is 2 ~ 10%.
In such scheme, step 2) described in solvent when being acetic acid aqueous solution, in chitosan solution, mass percent shared by chitosan is 0.1 ~ 15%; When solvent is sodium hydroxide/aqueous solution of urea, in chitosan solution, mass percent shared by chitosan is 0.1 ~ 6%.
In such scheme, described syringe needle is the syringe needle of syringe, and diameter is 0.21 ~ 0.90mm.
In such scheme, described step 3) in adopt single needle or Multi needle (2 ~ 50 syringe needles) mode to carry out electrostatic spray.
In such scheme, described electrostatic spray voltage is 20 ~ 24kV, the receiving range (distance on syringe needle and regenerated cellulose film surface) of electrostatic spray is 10 ~ 15cm, and the electrostatic spray time is 0.5 ~ 2h, and the flow rate control of electrostatic spray is at 0.6 ~ 2ml/h.
In such scheme, described regenerated cellulose film can be replaced marketed cellulose film, paper, gauze or cotton.
The chitin fiber element composite membrane obtained according to such scheme can be applicable to biological medicine, surface water purifies and the application of field of food.
Beneficial effect of the present invention is:
1) preparation method that the present invention relates to is physical process, and chemical reaction does not occur, environmental friendliness.
2) the present invention adopts the method coating chitosan solution of electrostatic spray in regenerated cellulose film surface, solves the shortcoming of chitosan not easily film forming, has prepared the wound dressing of base material porous.
3) the present invention operates facility, with low cost, environmental friendliness, is applicable to have the preparation of individual layer germ resistance composite membrane; The chitin fiber element composite membrane nontoxic pollution-free of preparation, there is good biocompatibility and biodegradability, and very strong anti-infection property and Blood clotting, wound healing can be promoted, strengthen immunological competence, be easy to functionalization and expand its Application Areas, the fields such as biological medicine, surface water purification and foodstuffs industry can be widely used in.
Accompanying drawing explanation
Fig. 1 is the scanning electron microscopic picture of obtained chitin fiber element composite membrane (right side) of embodiment 1 and pure cellulose film (left side).
Fig. 2 is the infrared spectrogram of chitin fiber element composite membrane, pure cellulose film and the chitosan that embodiment 1 obtains.
Fig. 3 is the plain composite membrane of chitin fiber and the swelling behavior sign of pure cellulose film in aqueous phase that embodiment 1 obtains.
Fig. 4 is the plain composite membrane of chitin fiber and pure cellulose film dynamic performance sign that embodiment 1 obtains.
Embodiment
In order to make object of the present invention, technical scheme and advantage clearly understand, below in conjunction with embodiment, the present invention is further elaborated.Should be appreciated that specific embodiment described herein only in order to explain the present invention, be not intended to limit the present invention.
In following examples, as no specific instructions, the reagent of employing is commercially available chemical reagent or Industrial products.
In following examples, described syringe needle is syringe needle.
Embodiment 1
A kind of preparation method of chitin fiber element composite membrane, concrete steps are as follows: cellosolve (sodium hydroxide/aqueous solution of urea, wherein the mass concentration of sodium hydroxide is 7%, the mass concentration of urea is 12%, all the other are water) is pre-chilled to-12 DEG C and obtains as cellosolve dissolving cellulos the cellulose solution that Mierocrystalline cellulose mass concentration is 4%; By curtain coating knifing after the deaeration of gained cellulose solution, removal of impurities, and at the middle solidification forming of precipitation bath (mass concentration is the sulphuric acid soln of 5%), after distilled water flushing, obtain regenerated cellulose film; Under agitation, be dissolved in by chitosan in acetic acid solution (mass percent shared by acetic acid is 90%), shared by preparation mass shell glycan, mass percent is the chitosan solution of 10%; With single needle (needle diameter is for 0.9mm) for nozzle, and be connected with electrostatic atomizer, suck the above-mentioned chitosan solution of 5ml, syringe needle is placed on apart from moistening regenerated cellulose film 15cm place, with the flow velocity electrostatic spray 1h of 2.0ml/h under the high direct voltage electrostatic forcing of 24kV, then wash, obtain described chitin fiber element composite membrane.
Fig. 1 is the scanning electron microscopic picture of obtained chitin fiber element composite membrane (right side) of the present embodiment and pure cellulose film (left side), can find out in figure, electrostatic spray coating chitosan solution is behind regenerated fibre film surface, and gained chitin fiber element composite membrane scanning electron microscopic picture still shows the pore structure of uniform compact; The present embodiment products therefrom is carried out Infrared spectroscopy, sees Fig. 2, in the infrared spectra of chitosan, 1559.3cm
-1the absorption peak at place corresponds to-NH
2formation vibration absorb, and gained chitin fiber element composite membrane in also there is this charateristic avsorption band, illustrating has stronger interaction between chitosan and Mierocrystalline cellulose; Products therefrom is carried out swelling behavior sign, the results are shown in Figure 3, can find out: compared with pure cellulose film, chitin fiber element composite membrane shows higher swelling behavior, mainly because the hydrophilicity of composite film surface chitosan improves swelling behavior.
This enforcement products therefrom is carried out mechanical property sign (see Fig. 4), result shows, the mechanical strength of the chitin fiber element composite membrane of preparation is compared with pure cellulose film certain reduction, but still meets the requirement of wound dressings mechanical strength.
The chitin fiber element composite membrane that the present embodiment obtains can provide barrier protection effect to skin wound, bacteria growing inhibiting, prevents wound inflammation from infecting; Also may be used for microbiotic in surface water, hormone absorption and remove and the wrapping material of field of food.
Embodiment 2
A kind of preparation method of chitin fiber element composite membrane, concrete steps are as follows: (sodium hydroxide/aqueous solution of urea, wherein the mass concentration of sodium hydroxide is 10%, the mass concentration of urea is 2%, all the other are water) is pre-chilled to-5 DEG C and obtains as cellosolve dissolving cellulos the cellulose solution that Mierocrystalline cellulose mass concentration is 0.5%; By curtain coating knifing after the deaeration of gained cellulose solution, removal of impurities, and at the middle solidification forming of precipitation bath (mass concentration is the sulphuric acid soln of 1%), after distilled water flushing, obtain regenerated cellulose film; Under agitation, be dissolved in by chitosan in acetic acid solution (mass percent shared by acetic acid is 2%), shared by preparation mass shell glycan, mass percent is the chitosan solution of 0.1%; With single needle (needle diameter is for 0.21mm) for nozzle, and be connected with electrostatic atomizer, suck the above-mentioned chitosan solution of 5ml, syringe needle is placed on apart from moistening regenerated cellulose film 10cm place, with the flow velocity electrostatic spray 2h of 0.6ml/h under the high direct voltage electrostatic forcing of 24kV, then wash, obtain described chitin fiber element composite membrane.
The chitin fiber element composite membrane that the present embodiment obtains can provide barrier protection effect to skin wound, bacteria growing inhibiting, prevents wound inflammation from infecting; Also may be used for microbiotic in surface water, hormone absorption and remove and the wrapping material of field of food.
Embodiment 3
A kind of preparation method of chitin fiber element composite membrane, concrete steps are as follows: (sodium hydroxide/aqueous solution of urea, wherein the mass concentration of sodium hydroxide is 7%, the mass concentration of urea is 12%, all the other are water) is pre-chilled to-12 DEG C and obtains as cellosolve dissolving cellulos the cellulose solution that Mierocrystalline cellulose mass concentration is 4%; By curtain coating knifing after the deaeration of gained cellulose solution, removal of impurities, and at the middle solidification forming of precipitation bath (mass concentration is the sulphuric acid soln of 5%), after distilled water flushing, obtain regenerated cellulose film; Under agitation, be dissolved in by chitosan in acetic acid solution (mass percent shared by acetic acid is 50%), shared by preparation mass shell glycan, mass percent is the chitosan solution of 0.1%; With 2 syringe needles (needle diameter is for 0.21mm) for nozzle, and be connected with electrostatic atomizer, suck the above-mentioned chitosan solution of 5ml, syringe needle is placed on apart from moistening regenerated cellulose film 10cm place, with the flow velocity electrostatic spray 0.5h of 0.6ml/h under the high direct voltage electrostatic forcing of 24kV, then wash, obtain described chitin fiber element composite membrane.
The chitin fiber element composite membrane that the present embodiment obtains can provide barrier protection effect to skin wound, bacteria growing inhibiting, prevents wound inflammation from infecting; Also may be used for microbiotic in surface water, hormone absorption and remove and the wrapping material of field of food.
Embodiment 4
A kind of preparation method of chitin fiber element composite membrane, concrete steps are as follows: (sodium hydroxide/aqueous solution of urea, wherein the mass concentration of sodium hydroxide is 7%, the mass concentration of urea is 12%, all the other are water) is pre-chilled to-5 DEG C and obtains as cellosolve dissolving cellulos the cellulose solution that Mierocrystalline cellulose mass concentration is 0.5%; By curtain coating knifing after the deaeration of gained cellulose solution, removal of impurities, and at the middle solidification forming of precipitation bath (mass concentration is the sulphuric acid soln of 1%), after distilled water flushing, obtain regenerated cellulose film; Under agitation, be dissolved in by chitosan in acetic acid solution (mass percent shared by acetic acid is 90%), shared by preparation mass shell glycan, mass percent is the chitosan solution of 15%; With 25 syringe needles (needle diameter is for 0.90mm) for nozzle, and be connected with electrostatic atomizer, suck the above-mentioned chitosan solution of 5ml, syringe needle is placed on apart from moistening regenerated cellulose film 15cm place, with the flow velocity electrostatic spray 2h of 1.0ml/h under the high direct voltage electrostatic forcing of 24kV, then wash, obtain described chitin fiber element composite membrane.
The chitin fiber element composite membrane that the present embodiment obtains can provide barrier protection effect to skin wound, bacteria growing inhibiting, prevents wound inflammation from infecting; Also may be used for microbiotic in surface water, hormone absorption and remove and the wrapping material of field of food.
Embodiment 5
A kind of preparation method of chitin fiber element composite membrane, concrete steps are as follows: (sodium hydroxide/aqueous solution of urea, wherein the mass concentration of sodium hydroxide is 6wt%, the mass concentration of urea is 10wt%, all the other are water) is pre-chilled to-7 DEG C and obtains as cellosolve dissolving cellulos the cellulose solution that Mierocrystalline cellulose mass concentration is 7%; By curtain coating knifing after the deaeration of gained cellulose solution, removal of impurities, and at the middle solidification forming of precipitation bath (aqueous solution), after distilled water flushing, obtain regenerated cellulose film; Under agitation, be dissolved in by chitosan in sodium hydroxide/aqueous solution of urea (mass percent shared by sodium hydroxide is 8%, and mass percent shared by urea is 2%), shared by preparation mass shell glycan, mass percent is the chitosan solution of 0.1%; With single needle (needle diameter is for 0.21mm) for nozzle, and be connected with electrostatic atomizer, suck the above-mentioned chitosan solution of 5ml, syringe needle is placed on apart from moistening regenerated cellulose film 10cm place, with the flow velocity electrostatic spray 2h of 2.0ml/h under the high direct voltage electrostatic forcing of 20kV, then wash, obtain described chitin fiber element composite membrane.
The chitin fiber element composite membrane that the present embodiment obtains can provide barrier protection effect to skin wound, bacteria growing inhibiting, prevents wound inflammation from infecting; Also may be used for microbiotic in surface water, hormone absorption and remove and the wrapping material of field of food.
Embodiment 6
A kind of preparation method of chitin fiber element composite membrane, concrete steps are as follows: sodium hydroxide/aqueous solution of urea, and wherein the mass concentration of sodium hydroxide is 10%, the mass concentration of urea is 20%, all the other are water) be pre-chilled to-12 DEG C and obtain as cellosolve dissolving cellulos the cellulose solution that Mierocrystalline cellulose mass concentration is 15%; By curtain coating knifing after the deaeration of gained cellulose solution, removal of impurities, and at the middle solidification forming of precipitation bath (aqueous solution), after distilled water flushing, obtain regenerated cellulose film; Under agitation, be dissolved in by chitosan in sodium hydroxide/aqueous solution of urea (mass percent shared by sodium hydroxide is 12%, and mass percent shared by urea is 10%), shared by preparation mass shell glycan, mass percent is the chitosan solution of 6%; With single needle (needle diameter is for 0.60mm) for nozzle, and be connected with electrostatic atomizer, suck the above-mentioned chitosan solution of 5ml, syringe needle is placed on apart from moistening regenerated cellulose film 15cm place, with the flow velocity electrostatic spray 1h of 1.0ml/h under the high direct voltage electrostatic forcing of 20kV, then wash, obtain described chitin fiber element composite membrane.
The chitin fiber element composite membrane that the present embodiment obtains can provide barrier protection effect to skin wound, bacteria growing inhibiting, prevents wound inflammation from infecting; Also may be used for microbiotic in surface water, hormone absorption and remove and the wrapping material of field of food.
Embodiment 7
A kind of preparation method of chitin fiber element composite membrane, concrete steps are as follows: sodium hydroxide/aqueous solution of urea, and wherein the mass concentration of sodium hydroxide is 6%, the mass concentration of urea is 10%, all the other are water) be pre-chilled to-7 DEG C and obtain as cellosolve dissolving cellulos the cellulose solution that Mierocrystalline cellulose mass concentration is 7%; By curtain coating knifing after the deaeration of gained cellulose solution, removal of impurities, and at the middle solidification forming of precipitation bath (aqueous solution), after distilled water flushing, obtain regenerated cellulose film; Under agitation, be dissolved in by chitosan in sodium hydroxide/aqueous solution of urea (mass percent shared by sodium hydroxide is 10%, and mass percent shared by urea is 6%), shared by preparation mass shell glycan, mass percent is the chitosan solution of 3%; With 25 syringe needles (needle diameter is for 0.21mm) for nozzle, and be connected with electrostatic atomizer, suck the above-mentioned chitosan solution of 5ml, syringe needle is placed on apart from moistening regenerated cellulose film 10cm place, with the flow velocity electrostatic spray 0.5h of 2.0ml/h under the high direct voltage electrostatic forcing of 24kV, then wash, obtain described chitin fiber element composite membrane.
The chitin fiber element composite membrane that the present embodiment obtains can provide barrier protection effect to skin wound, bacteria growing inhibiting, prevents wound inflammation from infecting; Also may be used for microbiotic in surface water, hormone absorption and remove and the wrapping material of field of food.
Embodiment 8
A kind of preparation method of chitin fiber element composite membrane, concrete steps are as follows: sodium hydroxide/aqueous solution of urea, and wherein the mass concentration of sodium hydroxide is 10%, the mass concentration of urea is 20%, all the other are water) be pre-chilled to-12 DEG C and obtain as cellosolve dissolving cellulos the cellulose solution that Mierocrystalline cellulose mass concentration is 15%; By curtain coating knifing after the deaeration of gained cellulose solution, removal of impurities, and at the middle solidification forming of precipitation bath (aqueous solution), after distilled water flushing, obtain regenerated cellulose film; Under agitation, be dissolved in by chitosan in sodium hydroxide/aqueous solution of urea (mass percent shared by sodium hydroxide is 12%, and mass percent shared by urea is 10%), shared by preparation mass shell glycan, mass percent is the chitosan solution of 6%; With 50 syringe needles (needle diameter is for 0.90mm) for nozzle, and be connected with electrostatic atomizer, suck the above-mentioned chitosan solution of 5ml, syringe needle is placed on apart from moistening regenerated cellulose film 15cm place, with the flow velocity electrostatic spray 2h of 0.6ml/h under the high direct voltage electrostatic forcing of 24kV, then wash, obtain described chitin fiber element composite membrane.
The present invention can by changing the concentration of chitosan solution used, the specification of syringe needle and quantity, the flow velocity of electrostatic spray, and the conditions such as the kind of matrix control the final effect of chitin fiber element composite membrane.
Chitin fiber element composite membrane obtained for embodiment 1 ~ 8 is carried out bacteriostatic test, concrete steps are as follows: pure cellulose film and Chitosan/Cellulose composite membrane (chitin fiber element composite membrane) are cut into the disk that diameter is 1-3cm, tightly be flattened on the agar media surface of inoculation test bacterial classification, cultivate 24 hours under 37 DEG C of temperature condition, media surface grows thickly dotted bacterium colony, and around sample, have the haloing of not long bacterium colony, measure the width of haloing ring.Known through overtesting, do not occur inhibition zone around pure cellulose film, and the width of the inhibition zone of chitin fiber element composite membrane prepared by embodiment 1 ~ 8 is 0.1 ~ 5.0mm, proves that obtained Chitosan/Cellulose composite membrane has good germ resistance.
The preparation method that the present invention relates to is simple, with low cost, nontoxic pollution-free, obtained chitin fiber element composite membrane has good biocompatibility and biodegradability, and very strong anti-infection property and Blood clotting, wound healing can be promoted, strengthen immunological competence, barrier protection effect can be provided to skin wound, bacteria growing inhibiting, prevent wound inflammation from infecting; Also may be used for microbiotic in surface water, hormone absorption and remove and the wrapping material of field of food.
Above embodiment is better embodiment of the present invention, but embodiments of the present invention are not limited thereto, as long as replace the amendment of the various equivalent form of value of the present invention, and all should within protection scope of the present invention.
Claims (10)
1. a preparation method for chitin fiber element composite membrane, adopt electrostatic spraying processes to apply chitosan solution on cellulosic matrix mould material, concrete steps are as follows:
1) cellosolve is chilled to-12 ~-5 DEG C in advance, adds Mierocrystalline cellulose stirring and dissolving and obtain cellulose solution, cellulose solution is carried out curtain coating knifing after deaeration, removal of impurities, and in precipitation bath solidification forming, then wash, obtain regenerated cellulose film;
2) chitosan is dissolved in solvent, the chitosan solution that must mix;
3) using syringe needle as nozzle, adopt electrostatic spray mode that chitosan solution is coated on regenerated cellulose film surface, after washing described chitin fiber element composite membrane.
2. preparation method according to claim 1, is characterized in that, described cellosolve is sodium hydroxide/aqueous solution of urea; Precipitation bath is water or dilute acid solution; Step 2) described in solvent be acetic acid solution or sodium hydroxide/aqueous solution of urea.
3. preparation method according to claim 2, is characterized in that, in described cellosolve, the mass concentration of sodium hydroxide is 6 ~ 10%, and the mass concentration of urea is 2 ~ 20%, and all the other are water; In cellulose solution, mass percent shared by Mierocrystalline cellulose is 0.5 ~ 15%.
4. preparation method according to claim 2, is characterized in that, step 2) described in solvent when being acetic acid solution, mass percent shared by acetic acid is 2 ~ 90%, and in chitosan solution, mass percent shared by chitosan is 0.1 ~ 15%; When solvent is sodium hydroxide/aqueous solution of urea, mass percent shared by sodium hydroxide is 8 ~ 12%, and mass percent shared by urea is 2 ~ 10%, and in chitosan solution, mass percent shared by chitosan is 0.1 ~ 6%.
5. preparation method according to claim 1, is characterized in that, described syringe needle is the syringe needle of syringe, and diameter is 0.21 ~ 0.90mm.
6. preparation method according to claim 1, is characterized in that, described step 3) in adopt single needle or Multi needle mode to carry out electrostatic spray, the syringe needle that wherein Multi needle mode adopts is 2 ~ 50.
7. preparation method according to claim 1, is characterized in that, described electrostatic spray voltage is 20 ~ 24kV, and the receiving range of electrostatic spray is 10 ~ 15cm, and the electrostatic spray time is 0.5 ~ 2h, and the flow rate control of electrostatic spray is at 0.6 ~ 2.0ml/h.
8. preparation method according to claim 1, is characterized in that, described regenerated cellulose film can be replaced marketed cellulose film, paper, gauze or cotton.
9. the chitin fiber element composite membrane that preparation method obtains according to any one of claim 1 ~ 8.
10. described in any one of claim 1 ~ 8, preparation method obtains chitin fiber element composite membrane is in the application of biological medicine, surface water purification or field of food.
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